CN117530895B - Compound plant extract with moisturizing effect and preparation and application thereof - Google Patents
Compound plant extract with moisturizing effect and preparation and application thereof Download PDFInfo
- Publication number
- CN117530895B CN117530895B CN202410028211.XA CN202410028211A CN117530895B CN 117530895 B CN117530895 B CN 117530895B CN 202410028211 A CN202410028211 A CN 202410028211A CN 117530895 B CN117530895 B CN 117530895B
- Authority
- CN
- China
- Prior art keywords
- extract
- parts
- compound plant
- preparation
- plant extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000419 plant extract Substances 0.000 title claims abstract description 92
- 150000001875 compounds Chemical class 0.000 title claims abstract description 90
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 82
- 238000002360 preparation method Methods 0.000 title claims abstract description 67
- 239000000284 extract Substances 0.000 claims abstract description 125
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 47
- 241000026010 Dendrobium candidum Species 0.000 claims abstract description 37
- 241000219357 Cactaceae Species 0.000 claims abstract description 36
- 229940069521 aloe extract Drugs 0.000 claims abstract description 36
- 244000042430 Rhodiola rosea Species 0.000 claims abstract description 31
- 235000003713 Rhodiola rosea Nutrition 0.000 claims abstract description 31
- 229940045761 evening primrose extract Drugs 0.000 claims abstract description 31
- 235000008524 evening primrose extract Nutrition 0.000 claims abstract description 31
- 239000002537 cosmetic Substances 0.000 claims abstract description 17
- 230000003712 anti-aging effect Effects 0.000 claims abstract description 12
- 238000000605 extraction Methods 0.000 claims description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- 239000007788 liquid Substances 0.000 claims description 29
- 238000009210 therapy by ultrasound Methods 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 25
- 238000010992 reflux Methods 0.000 claims description 24
- 108010059892 Cellulase Proteins 0.000 claims description 22
- 229940106157 cellulase Drugs 0.000 claims description 22
- 238000010298 pulverizing process Methods 0.000 claims description 19
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 15
- 241001076416 Dendrobium tosaense Species 0.000 claims description 14
- 238000004537 pulping Methods 0.000 claims description 14
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 229940088598 enzyme Drugs 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 241001116389 Aloe Species 0.000 claims description 8
- 235000011399 aloe vera Nutrition 0.000 claims description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 8
- 230000036571 hydration Effects 0.000 abstract description 6
- 238000006703 hydration reaction Methods 0.000 abstract description 6
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 abstract description 4
- 239000002552 dosage form Substances 0.000 abstract description 2
- 230000007760 free radical scavenging Effects 0.000 abstract description 2
- 231100000344 non-irritating Toxicity 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 48
- 239000000203 mixture Substances 0.000 description 30
- 239000000243 solution Substances 0.000 description 27
- 230000000052 comparative effect Effects 0.000 description 23
- 239000006210 lotion Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 238000001035 drying Methods 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 235000019441 ethanol Nutrition 0.000 description 9
- 238000000926 separation method Methods 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 241000195974 Selaginella Species 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 238000000746 purification Methods 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 7
- 239000006071 cream Substances 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 230000032683 aging Effects 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000341 volatile oil Substances 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 241000219925 Oenothera Species 0.000 description 3
- 235000004496 Oenothera biennis Nutrition 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 238000010009 beating Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- -1 facial mask Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 230000005808 skin problem Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003679 aging effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037365 barrier function of the epidermis Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008269 hand cream Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
- 229940033080 omega-6 fatty acid Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a compound plant extract with a moisturizing effect, and preparation and application thereof, and relates to the technical field of cosmetics. The compound plant extract comprises the following components in parts by weight: 3-10 parts of aloe extract, 2-10 parts of cactus extract, 3-15 parts of rhodiola rosea extract, 2.5-6 parts of dendrobium candidum stem extract and 2-6 parts of evening primrose extract; the extracts in the components are extracted by specific different methods respectively, and the extracts are synergistically enhanced, so that the moisturizing effect and the anti-aging effect are remarkably improved, the hydration rate is improved, the transdermal water loss rate is remarkably reduced, and the DPPH free radical scavenging rate is remarkably improved. The compound plant extract is applied to the preparation of cosmetics with various dosage forms and moisturizing and anti-aging effects, and is safe and non-irritating.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a compound plant extract with a moisturizing effect, and preparation and application thereof.
Background
Skin water shortage often causes various skin problems such as dry and dead skin, wrinkling, greasy skin, blackish head, dark and oxidized skin and the like, and the external environment affects skin invasion, sleep deficiency and various pressures, so that the skin is dried and damaged from inside to outside, and the skin is dry and loses elasticity, thereby causing aging problems. Therefore, it is necessary to perform a moisturizing operation on the skin.
The moisturizing is aimed at skin, when the air temperature is reduced, the skin cuticle can not timely adjust enough moisturizing factors, the activity of oil glands is reduced, the oil and water on the face are reduced, and the skin is tensed and even fine lines appear. The process of moisturizing skin, preventing skin moisture evaporation, improving skin microcirculation and enhancing skin wettability is called moisturizing by using corresponding products with moisturizing effect ingredients. In the daily skin care process, moisturizing components are added into the cosmetics, so that the aim of maintaining or increasing the moisture content of the skin cuticle is to improve and solve the common skin problems, a certain amount of moisturizing can be timely fused with the skin, the deep part of the cuticle is quickly permeated, the moisturized skin looks more moist and crystal, has luster and elasticity, and the long-term moisturizing can also enhance the defending ability of the skin and generate more vitality.
In recent years, various moisturizing compositions used in cosmetics have been studied, and chemical moisturizing compositions such as glycerin, butylene glycol, ceramide, and hyaluronic acid have been mainly used, but excessive use of chemical compositions may cause a burden on the skin. Therefore, the natural plant active ingredients with small irritation, being friendly to various skins and having moisturizing effect are increasingly paid attention to.
The Chinese patent publication No. CN115137675A discloses a compound plant extract with moisturizing effect and application thereof, wherein the extract comprises the following components: aloe extract, cactus extract, dendrobium candidum stem extract and selaginella extract. According to the invention, aloe extract, cactus extract, dendrobium candidum stem extract and selaginella extract are mixed according to a certain proportion, so that the effects of the extracts are synergistic, the aloe extract absorbs moisture in the air, the film forming property of the dendrobium candidum stem extract and the water locking capacity of the selaginella extract are used for preventing the volatilization of moisture on the surface of the skin, and the effects of relieving and resisting allergy, eliminating free radicals and moisturizing the skin are combined with the cactus, so that the effects of moisturizing and moisturizing are achieved in the way of comprehensively maintaining the epidermis barrier structure, the hydration function and the like. However, this study has not clearly led to a study of the correlation between plant extracts, and has not been clear about the technical development of the moisturizing effect.
The Chinese patent publication No. CN113057900A discloses a mild moisturizing composition and application thereof. The mild moisturizing composition comprises the following components in parts by mass: 0.04-0.06 parts of skin conditioning agent; 0.008-0.012 parts of sodium pyrrolidone carboxylate; 0.008-0.012 parts of oat polypeptide; 0.08-0.12 part of selaginella extract; 0.008-0.012 portions of emulsifying agent; the mild moisturizing composition provided by the application can be used in cosmetic water, cream, facial mask and essence, has a good moisturizing effect, is warm and fine in texture and easy to absorb, and simultaneously, the skin is more compact and fine after long-term use.
However, the moisturizing products currently on the market mainly have the following problems: 1. the moisturizing effect cannot last long; 2. the water is only floated on the surface of the skin; 3. the user feels sticky and greasy after using, and the discomfort is obvious; 4. when the moisturizing product is produced, a large amount of moisturizing components are added, and a plurality of moisturizing active components are added in the product, so that the moisturizing active components can be mutually influenced, the ideal moisturizing effect can not be achieved, and even the skin is damaged.
Therefore, it is important to research a compound plant extract and a product which have clear ingredients, clear effects of the ingredients, safety, quick and durable moisturizing effect, and improvement of skin darkness and aging, and have fresh and moist skin feel, no stickiness, good absorption, high safety and no allergic phenomenon.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides a compound plant extract with a moisturizing effect, and preparation and application thereof, wherein the compound plant extract comprises the following components: aloe extract, cactus extract, rhodiola rosea extract, dendrobium candidum stem extract and evening primrose extract; the extracts in the components are extracted by specific different methods respectively, and the extracts are synergistic, so that the moisturizing effect and the anti-aging effect are remarkably improved; the prepared cosmetic is safe, has no irritation, and has high moisturizing and antiaging effects.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
firstly, the invention provides a compound plant extract with a moisturizing effect, which comprises the following components in parts by weight: 3-10 parts of aloe extract, 2-10 parts of cactus extract, 3-15 parts of rhodiola rosea extract, 2.5-6 parts of dendrobium candidum stem extract and 2-6 parts of evening primrose extract.
Preferably, the compound plant extract comprises the following components in parts by weight: 5-8 parts of aloe extract, 6-9 parts of cactus extract, 8-12 parts of rhodiola rosea extract, 3-5 parts of dendrobium candidum stem extract and 3-5 parts of evening primrose extract.
Most preferably, the compound plant extract comprises the following components in parts by weight: 7 parts of aloe extract, 8 parts of cactus extract, 10 parts of rhodiola rosea extract, 4 parts of dendrobium candidum stem extract and 3.3 parts of evening primrose extract.
Preferably, the mass ratio of aloe extract, rhodiola rosea extract and evening primrose extract is 3-10:3-15:2-6; the mass ratio of aloe extract, rhodiola rosea extract and evening primrose extract is more preferably 5-8:8-12:3-5; the mass ratio of aloe extract, rhodiola rosea extract and evening primrose extract is most preferably 7:10:3.3.
Then, the invention provides a preparation method of the compound plant extract, which comprises the following steps:
(1) The preparation method of aloe extract comprises: pulping Aloe pulp, adding cellulase and pectase, performing enzymolysis, performing heat extraction, filtering, adding active carbon, and concentrating at low temperature to obtain Aloe extract;
(2) The preparation method of the cactus extract comprises the following steps: peeling radix et caulis Opuntiae Dillenii, pulping with water, adding cellulase and pectase for enzymolysis, adjusting pH to weak acidity, heating for extraction, filtering, adding active carbon, and concentrating at low temperature to obtain radix et caulis Opuntiae Dillenii extract;
(3) The preparation method of the rhodiola rosea extract comprises the following steps: pulverizing radix Rhodiolae, decocting with water, mixing the decoctions, purifying, and concentrating to obtain radix Rhodiolae extract;
(4) The preparation method of the dendrobium candidum stem extract comprises the following steps: pulverizing Dendrobium officinale stem to obtain Dendrobium officinale stem powder, mixing with ethanol solution, performing ultrasonic treatment, performing reflux extraction, purifying the extractive solution, and concentrating to obtain Dendrobium officinale stem extract;
(5) The preparation method of the evening primrose extract comprises the following steps: pulverizing radix Oenotherae Erythrosepalae, and steam extracting to obtain radix Oenotherae Erythrosepalae extract;
(6) Mixing the above extracts to obtain compound plant extract.
Preferably, in the step (1), the aloe pulp and the water are pulped by adding water, and the solid-to-liquid ratio of the aloe pulp to the water is 1:20-28g/mL.
Preferably, in the step (1), the mass ratio of the cellulase to the pectase is 1:1.5-2.5.
Still more preferably, the mass ratio of cellulase to pectase is 1:2.
Preferably, in the step (1), the enzymolysis treatment specifically includes: the enzymolysis temperature is 40-50 ℃, the enzyme addition amount is 0.2-2% of E/S, and the enzymolysis time is 2-4h.
Still further preferably, the enzymolysis treatment specifically comprises: the enzymolysis temperature is 45 ℃, the enzyme addition amount E/S is 1-1.5%, and the enzymolysis time is 3 hours.
Preferably, in step (1), the heat extraction treatment specifically includes: the extraction temperature is 70-80deg.C, and the extraction time is 1-2h.
Still further preferably, the heat extraction treatment specifically includes: the extraction temperature is 75 ℃ and the extraction time is 1.5h.
Preferably, in step (1), the activated carbon is added in an amount of 2-8% (m/v), corresponding to the volume of the mixture after beating; concentrating at low temperature below 60deg.C, and drying to obtain aloe extract.
Preferably, in the step (2), water is added for pulping, and the solid-to-liquid ratio of the cactus to the water is 1:15-25g/mL.
Preferably, in the step (2), the mass ratio of the cellulase to the pectase is 1:0.5-1.
Still more preferably, the mass ratio of the cellulase to the pectase is 1:0.8.
Preferably, in the step (2), the enzymolysis treatment specifically includes: the enzymolysis temperature is 45-55deg.C, the enzyme addition amount is E/S0.2-3%, and the enzymolysis time is 2-5 hr.
Still further preferably, the enzymolysis treatment specifically comprises: the enzymolysis temperature is 45-50 ℃, the enzyme addition amount E/S is 2-2.5%, and the enzymolysis time is 3-4h.
Preferably, in the step (2), the pH is adjusted to be slightly acidic, and the pH regulator is at least one selected from citric acid, malic acid and acetic acid; the pH was adjusted to 4-6.
Preferably, in the step (2), the heat extraction treatment specifically includes: the extraction temperature is 60-70deg.C, and the extraction time is 1-2h.
Still further preferably, the heat extraction treatment specifically includes: the extraction temperature is 65 ℃ and the extraction time is 1.5h.
Preferably, in step (2), the activated carbon is added in an amount of 2-8% (m/v), corresponding to the volume of the mixture after beating; concentrating at low temperature below 60deg.C, and drying to obtain radix et caulis Opuntiae Dillenii extract.
Preferably, in the step (3), the pulverization is carried out with a particle size of 50 to 100 mesh.
Preferably, in the step (3), the decoction is carried out for 2-4 times, the solid-liquid ratio is 1:5-15g/mL, and the time of each decoction is 0.5-2h.
Further preferably, the times of the decoction are 2-3 times, and the solid-liquid ratio of each decoction is 1:8-10g/mL; the first time is 0.5-1h, and the second and/or third time is 1-2h.
Preferably, in the steps (3) - (4), the purification and concentration are carried out by multistage membrane separation and concentration.
Preferably, in the step (4), the pulverization is carried out, and the particle size of the pulverization is 50-100 mesh.
Preferably, in the step (4), the volume concentration of the ethanol solution is 45-60%; the solid-to-liquid ratio of the dendrobium candidum stem powder to the ethanol solution is 1:10-20g/mL.
Further preferably, the ethanol solution has a volume concentration of 50-55%; the solid-to-liquid ratio of the dendrobium candidum stem powder to the ethanol solution is 1:12-15g/mL.
Preferably, in the step (4), the ultrasonic treatment is carried out for 30-50min, the ultrasonic treatment temperature is 40-60 ℃, and the ultrasonic treatment power is 40-60kHz.
Further preferably, the time of the ultrasonic treatment is 40min, the temperature of the ultrasonic treatment is 50 ℃, and the power of the ultrasonic treatment is 50kHz.
Preferably, in the step (4), the reflux extraction is carried out at a temperature of 45-55 ℃ for 1-3 hours; reflux extraction was repeated 1 time.
Further preferably, the reflux extraction is carried out at a temperature of 50-55 ℃ for 2 hours; reflux extraction was repeated 1 time.
Preferably, in step (5), the pulverization has a particle size of 150 to 300 mesh.
Preferably, in the step (5), the water vapor extraction is performed for 3-5 hours to obtain the evening primrose volatile oil, namely the evening primrose extract.
Furthermore, the invention provides application of the compound plant extract in cosmetics with moisturizing and anti-aging effects, wherein the compound plant extract in the application is the compound plant extract or the compound plant extract prepared by the preparation method.
Finally, the invention provides a cosmetic with moisturizing and anti-aging effects, which comprises a compound plant extract and raw material auxiliary materials which can be used in the field of cosmetics; the compound plant extract is prepared by the compound plant extract or the preparation method.
Preferably, the cosmetic comprises facial cleanser, lotion, moisturizing cream, essence, sun cream, sun spray, sun cream, facial mask, hand cream, body lotion, and bath lotion.
Preferably, the raw material auxiliary materials include, but are not limited to, emulsifying agents, pH adjusting agents, thickening agents and preservatives.
In the invention, the aloe extract contains rich vitamins, amino acids, organic acids, polysaccharides and other components, acts on the skin, is beneficial to moisturizing the skin, locking a moisture film and improving the dryness of the skin; and has antioxidant, skin metabolism promoting, skin repairing and improving effects.
In the invention, the cactus extract is an active ingredient extracted from the cactus through enzymolysis and acidic aqueous solution, is rich in natural moisturizing factors and anti-aging factors, can help skin to keep moisture and moisten, and has remarkable antioxidation effect by eliminating free radicals; meanwhile, the cactus is rich in Vc, so that the skin elasticity can be increased, and the regeneration and repair of cells can be promoted.
In the invention, the rhodiola rosea is also called golden root, has various water-soluble active ingredients, is used as a natural ore oxidant, and can limit the injury effect of free radical injury; the rhodiola rosea extract promotes the division of fibroblasts, and can effectively resist aging; meanwhile, the aloe extract and the evening primrose extract supplement each other, so that the effects of moisturizing and moisturizing are improved.
In the invention, the dendrobium candidum is rich in a plurality of amino acids, and the amino acids can supplement nutrition and moisture of skin, have good moisturizing effect and are easy to be absorbed by skin; research shows that the skin care product added with dendrobium candidum extract has the functions of resisting oxidation and delaying aging. However, the active ingredients obtained by different preparation methods are different, and the effects are different.
In the invention, the evening primrose extract, namely evening primrose volatile oil, is rich in Omega-6 fatty acids such as gamma-linolenic acid, linolenic acid and the like, has certain importance for maintaining skin health, can moisturize skin and has an aging effect.
Compared with the prior art, the invention has the following beneficial effects:
1. the compound plant extract has the effects of efficiently preserving moisture, improving the skin barrier function, improving the skin water locking capacity and resisting oxidization, and can delay skin aging while preserving moisture, so that the skin can be deeply maintained, effectively preserved, and has the effects of moisturizing, resisting aging and enabling the skin to be moist, smooth and not tight.
2. The compound plant extract disclosed by the invention has the advantages that the active ingredient extracts of plants are matched and combined, and the synergistic effect is achieved, so that compared with other single components or the compound plant extract not disclosed by the application, the compound plant extract has the remarkably improved moisturizing effect and anti-aging effect.
3. The components in the compound plant extract are extracted by a specific method respectively, different solvents and different process conditions are used for extraction, and the prepared extract has different components and compatibility with other components in the preparation, so that the compound plant extract has the technical effects of high antioxidation, moisture preservation and the like.
4. The preparation can be directly applied to the preparation of cosmetics in different dosage forms, and the prepared cosmetics have the advantages of moisturizing and non-greasy face, safety, no irritation, no adverse reaction and excellent moisturizing and anti-aging effects.
Detailed Description
The following non-limiting examples will enable those of ordinary skill in the art to more fully understand the invention and are not intended to limit the invention in any way. The following is merely exemplary of the scope of the invention as it is claimed and many variations and modifications of the invention will be apparent to those skilled in the art in light of the disclosure, which should be considered as falling within the scope of the invention as claimed.
Where numerical ranges are provided in the examples, it is understood that unless otherwise stated herein, both endpoints of each numerical range and any number between the two endpoints are significant both in the numerical range. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The invention is further illustrated by means of the following specific examples. The various chemical reagents used in the examples of the present invention were obtained by conventional commercial means unless otherwise specified. The components or chemical reagents in the invention have no obvious influence on the effect of products of different manufacturers.
Example 1
The compound plant extract with the moisturizing effect comprises the following components in parts by weight:
7 parts of aloe extract, 8 parts of cactus extract, 10 parts of rhodiola rosea extract, 4 parts of dendrobium candidum stem extract and 3.3 parts of evening primrose extract.
The preparation method of the compound plant extract comprises the following steps:
(1) The preparation method of aloe extract comprises: cleaning aloe, peeling, taking pulp part, adding water to a solid-to-liquid ratio of 1:25g/mL, pulping to obtain a fine pulp mixture, adding cellulase and pectase for enzymolysis at 45 ℃, wherein the enzyme addition amount E/S is 1.2%, and the enzymolysis time is 3h, wherein the mass ratio of the cellulase to the pectase is 1:2; heating to 75deg.C after enzymolysis, extracting for 1 hr, filtering, adding 5% (m/v) active carbon into the filtrate to remove ash and pigment, concentrating at 50deg.C, and drying to obtain aloe extract;
(2) The preparation method of the cactus extract comprises the following steps: cleaning and peeling cactus, taking cactus pulp, adding water to a solid-to-liquid ratio of 1:20g/mL, pulping to obtain a fine slurry mixture, adding cellulase and pectase for enzymolysis at 50 ℃, wherein the enzyme addition amount E/S is 2%, and the enzymolysis time is 3.5h, wherein the mass ratio of the cellulase to the pectase is 1:0.8; then dilute citric acid solution is used for regulating pH to be weak acid (pH is 5), then heating is continued to 65 ℃, heat preservation is carried out for 1.5 hours, filtration is carried out, 5% (m/v) active carbon is added into filtrate to remove impurities such as ash, pigment and the like, and low-temperature concentration and drying are carried out at 50 ℃ to obtain cactus extract;
(3) The preparation method of the rhodiola rosea extract comprises the following steps: pulverizing radix Rhodiolae to 80 mesh, mixing with water at solid-liquid ratio of 1:10g/mL (solid-liquid ratio of 1:10g/mL for each decoction), and decocting for 3 times, wherein the decoction comprises: the time of the first decoction is 0.5h, the time of the second decoction is 2h, and the time of the third decoction is 1h; filtering after each decoction to obtain decoction, mixing decoctions, multi-stage membrane separation and purification, and concentrating to obtain radix Rhodiolae extract.
(4) The preparation method of the dendrobium candidum stem extract comprises the following steps: pulverizing Dendrobium officinale stem to obtain Dendrobium officinale stem powder, mixing with ethanol solution with volume concentration of 55%, wherein the solid-to-liquid ratio of the mixture is 1:12g/mL, ultrasonic treatment is carried out firstly: the ultrasonic treatment time is 40min, the ultrasonic treatment temperature is 50 ℃, and the ultrasonic treatment power is 50kHz; and then transferring to perform heating reflux extraction treatment: reflux extraction temperature is 50 ℃, and reflux extraction time is 2 hours; reflux extraction is repeated for 1 time; combining the extracting solutions, and performing multistage membrane separation, purification and concentration to obtain a dendrobium candidum stem extract;
(5) The preparation method of the evening primrose extract comprises the following steps: pulverizing radix Oenotherae Erythrosepalae with particle diameter of 200 mesh, extracting with water vapor for 4 hr to obtain radix Oenotherae Erythrosepalae volatile oil as radix Oenotherae Erythrosepalae extract;
(6) Mixing the above extracts to obtain compound plant extract.
Example 2
The compound plant extract with the moisturizing effect comprises the following components in parts by weight:
5 parts of aloe extract, 6 parts of cactus extract, 8 parts of rhodiola rosea extract, 3 parts of dendrobium candidum stem extract and 3 parts of evening primrose extract.
The preparation method of the compound plant extract comprises the following steps:
(1) The preparation method of aloe extract comprises: cleaning aloe, peeling, taking pulp part, adding water to a solid-to-liquid ratio of 1:20g/mL, pulping to obtain a fine pulp mixture, adding cellulase and pectase for enzymolysis at 40 ℃, wherein the enzyme addition amount E/S is 1%, and the enzymolysis time is 4 hours, wherein the mass ratio of the cellulase to the pectase is 1:1.5; heating to 70deg.C, extracting for 2 hr, filtering, adding 4% (m/v) active carbon to remove ash and pigment, concentrating at 50deg.C, and drying to obtain aloe extract;
(2) The preparation method of the cactus extract comprises the following steps: cleaning and peeling cactus, taking cactus pulp, adding water to a solid-to-liquid ratio of 1:15g/mL, pulping to obtain a fine slurry mixture, adding cellulase and pectase for enzymolysis at 45 ℃, wherein the enzyme addition amount E/S is 2.5%, and the enzymolysis time is 3 hours, and the mass ratio of the cellulase to the pectase is 1:0.5; then adjusting pH to weak acidity (pH 4) with dilute citric acid solution, heating to 60deg.C, extracting for 2 hr, filtering, adding 4% (m/v) active carbon into filtrate to remove ash and pigment, concentrating at 50deg.C, and drying to obtain radix et caulis Opuntiae Dillenii extract;
(3) The preparation method of the rhodiola rosea extract comprises the following steps: pulverizing radix Rhodiolae to 50 mesh, mixing with water at solid-liquid ratio of 1:5g/mL, and decocting for 2 times (solid-liquid ratio of 1:5g/mL for each decoction), wherein the decoction comprises: the time of the first decoction is 1h, and the time of the second decoction is 2h; filtering after each decoction to obtain decoction, mixing decoctions, multi-stage membrane separation and purification, and concentrating to obtain radix Rhodiolae extract.
(4) The preparation method of the dendrobium candidum stem extract comprises the following steps: pulverizing Dendrobium officinale stem to obtain Dendrobium officinale stem powder, mixing with 50% ethanol solution, and mixing at a solid-to-liquid ratio of 1:15g/mL, ultrasonic treatment is carried out firstly: the ultrasonic treatment time is 30min, the ultrasonic treatment temperature is 40 ℃, and the ultrasonic treatment power is 60kHz; and then transferring to perform heating reflux extraction treatment: reflux extraction temperature is 55deg.C, and reflux extraction time is 2.5h; reflux extraction is repeated for 1 time; combining the extracting solutions, and performing multistage membrane separation, purification and concentration to obtain a dendrobium candidum stem extract;
(5) The preparation method of the evening primrose extract comprises the following steps: pulverizing radix Oenotherae Erythrosepalae with particle diameter of 150 mesh, extracting with water vapor for 5 hr to obtain radix Oenotherae Erythrosepalae volatile oil as radix Oenotherae Erythrosepalae extract;
(6) Mixing the above extracts to obtain compound plant extract.
Example 3
The compound plant extract with the moisturizing effect comprises the following components in parts by weight:
8 parts of aloe extract, 9 parts of cactus extract, 12 parts of rhodiola rosea extract, 5 parts of dendrobium candidum stem extract and 5 parts of evening primrose extract.
The preparation method of the compound plant extract comprises the following steps:
(1) The preparation method of aloe extract comprises: cleaning aloe, peeling, taking pulp part, adding water to a solid-to-liquid ratio of 1:28g/mL, pulping to obtain a fine pulp mixture, adding cellulase and pectase for enzymolysis at 50 ℃, wherein the enzyme addition amount E/S is 2%, and the enzymolysis time is 2h, wherein the mass ratio of the cellulase to the pectase is 1:2.5; heating to 80deg.C after enzymolysis, extracting for 1 hr under heat preservation, filtering, adding 6% (m/v) active carbon into filtrate to remove ash and pigment, concentrating at 55deg.C, and drying to obtain aloe extract;
(2) The preparation method of the cactus extract comprises the following steps: cleaning and peeling cactus, taking cactus pulp, adding water to a solid-to-liquid ratio of 1:25g/mL, pulping to obtain a fine slurry mixture, adding cellulase and pectase for enzymolysis at 55 ℃, wherein the enzyme addition amount E/S is 1.5%, and the enzymolysis time is 2.5h, and the mass ratio of the cellulase to the pectase is 1:1; then adjusting pH to weak acidity (pH is 6) with dilute citric acid solution, heating to 70deg.C, extracting for 2 hr, filtering, adding 6% (m/v) active carbon into filtrate to remove ash and pigment, concentrating at 55deg.C, and drying to obtain radix et caulis Opuntiae Dillenii extract;
(3) The preparation method of the rhodiola rosea extract comprises the following steps: pulverizing radix Rhodiolae to 100 mesh, mixing with water at solid-liquid ratio of 1:15g/mL (solid-liquid ratio of 1:15g/mL for each decoction), and decocting for 3 times, wherein the specific steps are: the time of the first decoction is 0.5h, the time of the second decoction is 1h, and the time of the third decoction is 2h; filtering after each decoction to obtain decoction, mixing decoctions, multi-stage membrane separation and purification, concentrating, and drying to obtain radix Rhodiolae extract.
(4) The preparation method of the dendrobium candidum stem extract comprises the following steps: pulverizing Dendrobium officinale stem to obtain Dendrobium officinale stem powder, mixing with ethanol solution with volume concentration of 60% and solid-liquid ratio of 1:10g/mL, ultrasonic treatment is carried out firstly: the ultrasonic treatment time is 50min, the ultrasonic treatment temperature is 60 ℃, and the ultrasonic treatment power is 40kHz; and then transferring to perform heating reflux extraction treatment: the reflux extraction temperature is 45 ℃, and the reflux extraction time is 3 hours; reflux extraction is repeated for 1 time; combining the extracting solutions, separating, purifying and concentrating by using a multi-stage membrane, and drying to obtain a dendrobium candidum stem extract;
(5) The preparation method of the evening primrose extract comprises the following steps: pulverizing radix Oenotherae Erythrosepalae with particle diameter of 300 mesh, extracting with water vapor for 4 hr to obtain radix Oenotherae Erythrosepalae volatile oil as radix Oenotherae Erythrosepalae extract;
(6) Mixing the above extracts to obtain compound plant extract.
Example 4
Unlike example 1, the compound plant extract has different weight parts of each component, specifically:
the compound plant extract with the moisturizing effect comprises the following components in parts by weight:
3 parts of aloe extract, 2 parts of cactus extract, 3 parts of rhodiola rosea extract, 2.5 parts of dendrobium candidum stem extract and 2 parts of evening primrose extract.
The preparation method of the compound plant extract is the same as in example 1.
Example 5
Unlike example 1, the compound plant extract has different weight parts of each component, specifically:
the compound plant extract with the moisturizing effect comprises the following components in parts by weight:
10 parts of aloe extract, 10 parts of cactus extract, 15 parts of rhodiola rosea extract, 6 parts of dendrobium candidum stem extract and 6 parts of evening primrose extract.
The preparation method of the compound plant extract is the same as in example 1.
Application example 1
The moisturizing cream comprising the compound plant extract of the embodiment 1 or the embodiment 3 and the preparation thereof adopts raw material auxiliary materials and processes which can be used in the production process of cosmetics-face cream for preparing the moisturizing cream, and specifically comprises the following steps:
(1) Dissolving and mixing the compound plant extract described in the embodiment 1 by using a glycerol-water solution with the concentration of 15%, so as to obtain a glycerol water solution of the compound plant extract;
(2) Adding a thickener (xanthan gum) into deionized water, heating to 85 ℃ (water phase), and adding an oil phase: adding caprylic/capric triglyceride, cetostearyl glucoside, cetylstearyl alcohol and lecithin emulsifier into an oil pot, completely dissolving, respectively pumping the water phase and the oil phase into the emulsifying pot, homogenizing under vacuum for 10 minutes, stirring and cooling to 45 ℃, adding preservative (phenoxyethanol), and stirring for 20 minutes until completely uniform to obtain an auxiliary material mixture;
(3) Cooling the auxiliary material mixture in the step (2) to 40 ℃, and uniformly mixing and stirring the auxiliary material mixture and the glycerol aqueous solution of the compound plant extract in the step (1) to obtain the moisturizing cream.
The formula of the moisturizing cream comprises the following components in percentage by mass:
application example 2
The moisturizing water comprising the compound plant extract of example 1 or example 2 and the preparation thereof adopts raw material auxiliary materials and processes which can be used in the cosmetic-moisturizing water production process to prepare the moisturizing water, and specifically comprises the following steps:
(1) Dissolving and mixing the compound plant extract described in the embodiment 1 by using a glycerol-water solution with the concentration of 10%, so as to obtain a glycerol water solution of the compound plant extract;
(2) Preheating deionized water and EDTA-2Na to 60 ℃, adding sodium hyaluronate and preservative (phenoxyethanol) under stirring, and stirring for 20min to completely uniformity to obtain an auxiliary material mixture;
(3) And (3) cooling the auxiliary material mixture in the step (2) to 40 ℃, and uniformly mixing and stirring the auxiliary material mixture with the glycerol aqueous solution of the compound plant extract in the step (1) to obtain the moisturizing water.
The formula of the moisturizing water comprises the following components in percentage by mass:
comparative example 1
Unlike example 1, the compound plant extract contains no rhodiola rosea extract, i.e. comprises the following components in parts by weight: 7 parts of aloe extract, 8 parts of cactus extract, 4 parts of dendrobium candidum stem extract and 3.3 parts of evening primrose extract.
The other components were the same as in example 1 to obtain a compound plant extract.
The compound plant extract was subjected to the preparation of the moisturizing lotion of comparative example 1 according to the preparation method and formulation described in application example 2 moisturizing lotion 2 (replaced with the compound plant extract of comparative example 1 described above).
Comparative example 2
Unlike example 1, the plant extract was only rhodiola rosea extract, and the rhodiola rosea extract was prepared in the same manner as in example 1.
The preparation of the moisturizing lotion of comparative example 2 was performed according to the preparation method and formulation described in application example 2 moisturizing lotion 2 (the compound plant extract was replaced with rhodiola rosea extract of comparative example 2 described above).
Comparative example 3
Unlike example 1, the evening primrose extract was replaced with the selaginella extract.
Namely a compound plant extract, which comprises the following components in parts by weight: 7 parts of aloe extract, 8 parts of cactus extract, 10 parts of rhodiola rosea extract, 4 parts of dendrobium candidum stem extract and 3.3 parts of selaginella extract.
The preparation method of the selaginella extract comprises the following steps: taking fresh selaginella, cleaning, draining, pulping, putting into a container, adding deionized water as a solvent (solid-liquid ratio is 1:15 g/mL), and putting into a heating stirrer; extracting at 70deg.C with stirring for 2 hr, filtering the mixed solution with 300 mesh sieve, adding 5% (m/v) active carbon, standing for 24 hr, filtering, collecting filtrate, adding 30% butanediol as solvent, and performing multistage membrane separation and concentration to obtain herba Selaginellae extract.
The other components were the same as in example 1 to obtain a compound plant extract.
The compound plant extract was subjected to the preparation of the moisturizing lotion of comparative example 3 according to the preparation method and formulation described in application example 2 moisturizing lotion 2 (replaced with the compound plant extract of comparative example 3 described above).
Comparative example 4
Unlike example 1, the preparation method of dendrobium candidum stem extract in the compound plant extract is different, specifically:
the preparation method of the dendrobium candidum stem extract comprises the following steps: the dendrobium candidum stem is crushed to obtain dendrobium candidum stem powder, the grain diameter is about 80 meshes, the dendrobium candidum stem powder is mixed with water, and the mixed solid-liquid ratio is 1:12g/mL, ultrasonic treatment is carried out firstly: the ultrasonic treatment time is 40min, the ultrasonic treatment temperature is 50 ℃, and the ultrasonic treatment power is 50kHz; then 3 times of decoction (the solid-to-liquid ratio of each decoction is 1:12 g/mL) are carried out, wherein the decoction is specifically as follows: the time of the first decoction is 0.5h, the time of the second decoction is 2h, and the time of the third decoction is 1h; filtering after each decoction to obtain decoction, mixing decoctions, multi-stage membrane separation and purification, and concentrating to obtain Dendrobium officinale stem extract.
The components and formulation of the compound plant extract and the preparation method of the rest components are the same as in example 1.
The compound plant extract was subjected to the preparation of moisturizing lotion of comparative example 4 according to the preparation method and formulation described in application example 2 moisturizing lotion 2 (replaced with the compound plant extract of comparative example 4 described above).
Comparative example 5
Unlike example 1, the preparation method of the evening primrose extract in the compound plant extract is different, specifically:
crushing the roots of evening primrose, mixing with ethanol solution with the volume concentration of 55% and the particle size of 200 meshes, wherein the solid-liquid ratio of the mixture is 1:12g/mL, heating reflux extraction treatment: reflux extraction temperature is 50 ℃, and reflux extraction time is 2 hours; reflux extraction is repeated for 1 time; and combining the extracting solutions, performing multistage membrane separation, purification and concentration to obtain the evening primrose extract.
The components and formulation of the compound plant extract and the preparation method of the rest components are the same as in example 1.
The compound plant extract was subjected to the preparation of the moisturizing lotion of comparative example 5 according to the preparation method and formulation described in application example 2 moisturizing lotion 2 (replaced with the compound plant extract of comparative example 5 described above).
Comparative example 6
Unlike example 1, the aloe extract, the rhodiola rosea extract and the evening primrose extract are different in parts by weight, specifically, the compound plant extract comprises the following components in parts by weight: 15 parts of aloe extract, 8 parts of cactus extract, 2 parts of rhodiola rosea extract, 4 parts of dendrobium candidum stem extract and 1.5 parts of evening primrose extract.
The remainder was the same as in example 1.
The compound plant extract was subjected to the preparation of the moisturizing lotion of comparative example 6 according to the preparation method and formulation described in application example 2 moisturizing lotion 2 (replaced with the compound plant extract of comparative example 6 described above).
Comparative test 1 moisture efficacy detection
Detecting a sample: the compound plant extracts described in examples 1 to 5 and comparative examples 1 to 6 were used in moisturizing lotion 1 described in example 2. Before detection, each compound plant extract is dissolved by using a glycerol-water solution with the concentration of 10%, and the concentration of the compound plant extract in the obtained reagent is 3%. And then smearing and detecting the paint.
The detection method comprises the following steps: marking 3X 3cm on the left and right forearm flexor sides of the test taker 2 The left arm is used as a test area of a sample in a square test area with a large size, 3g of the sample is smeared each time, and the smearing is uniform; the corresponding symmetric area of the right arm is a blank (after hydration rate detection, 10% glycerin-water solution is applied daily for skin care, blank value), then Corneometer CM825 is used for testing the moisture content of each test part, and the test of the same subject is completed by the same tester. The hydration rate was calculated by the following formula.
Hydration = (test value-blank value)/blank value x 100%.
At the same time, the transdermal water loss rate (TEWL) was measured on days 0 and 28.
Test environment: the test environment temperature is 22+/-1 ℃, the humidity is 50+/-5%, and the real-time dynamic monitoring is carried out.
The test taker requires: 72 people (except pregnant or lactating women) of healthy people with the age of 20-45 years have no history of skin and systemic diseases, no hormone medicine and immunosuppressant are used in the last month, and the skin of the tested part has no abnormality and no obvious scar or injury. The test sites were not coated with any cosmetics or external preparations except the test samples 1 day before and throughout the test period. Each group of subjects was 6 persons.
The hydration rate detection results of the skin moisture content before and after the compound plant extract is used are shown in table 1.
TABLE 1
In table 1, P < 0.05, P < 0.01 compared to example 1.
As can be seen from table 1, the compound plant extract provided by the invention can effectively improve the moisturizing effect, remarkably improve the skin barrier function and promote the water locking capability of the skin.
Comparative test 2 anti-aging efficacy test
Detecting a sample: the compound plant extracts described in examples 1-5 and comparative examples 1-6.
The detection method comprises the following steps: DPPH free radical scavenging experiment, preparing 0.1mmol/L DPPH solution with absolute ethyl alcohol, and storing in dark at 0-4deg.C, wherein the preparation is effective within 4h. Samples (compound plant extracts) were prepared as 1mg/mL of the sample solution to be tested. The positive control group is prepared by selecting 1mg/mL vitamin C, and storing at 0-4deg.C in dark place. The reagents were added as in table 2 below. The reaction was kept away from light for 30min and the absorbance of ABC was measured at 520 nm. Experiments were performed in 5 replicates. DPPH free radical inhibition rate calculation formula: DPPH inhibition (%) = (b+c-se:Sub>A)/bx 100%.
The detection results are shown in Table 3.
TABLE 2
TABLE 3 Table 3
In table 3, P < 0.05, P < 0.01 compared to example 1.
As can be seen from Table 3, the antioxidant capacity of the compound plant extract prepared by the invention is significantly better than that of the comparative example. And the components are matched with each other in a synergistic way, so that the effects of moisturizing and resisting oxidation are remarkably improved.
Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.
Claims (5)
1. The compound plant extract with the moisturizing effect is characterized by comprising the following components in parts by weight: 3-10 parts of aloe extract, 2-10 parts of cactus extract, 3-15 parts of rhodiola rosea extract, 2.5-6 parts of dendrobium candidum stem extract and 2-6 parts of evening primrose extract;
the compound plant extract is prepared by a preparation method comprising the following steps:
(1) The preparation method of aloe extract comprises: pulping Aloe pulp, adding cellulase and pectase, performing enzymolysis, performing heat extraction, filtering, adding active carbon, and concentrating at low temperature to obtain Aloe extract;
(2) The preparation method of the cactus extract comprises the following steps: peeling radix et caulis Opuntiae Dillenii, pulping with water, adding cellulase and pectase for enzymolysis, adjusting pH to weak acidity, heating for extraction, filtering, adding active carbon, and concentrating at low temperature to obtain radix et caulis Opuntiae Dillenii extract;
(3) The preparation method of the rhodiola rosea extract comprises the following steps: pulverizing radix Rhodiolae, decocting with water, mixing the decoctions, purifying, and concentrating to obtain radix Rhodiolae extract;
(4) The preparation method of the dendrobium candidum stem extract comprises the following steps: pulverizing Dendrobium officinale stem to obtain Dendrobium officinale stem powder, mixing with ethanol solution, performing ultrasonic treatment, performing reflux extraction, purifying the extractive solution, and concentrating to obtain Dendrobium officinale stem extract;
(5) The preparation method of the evening primrose extract comprises the following steps: pulverizing radix Oenotherae Erythrosepalae, and steam extracting to obtain radix Oenotherae Erythrosepalae extract;
(6) Mixing the above extracts to obtain compound plant extract;
in the step (1), water is added for pulping, and the solid-to-liquid ratio of aloe pulp to water is 1:20-28g/mL; the mass ratio of the cellulase to the pectase is 1:1.5-2.5; the enzymolysis treatment specifically comprises the following steps: the enzymolysis temperature is 40-50 ℃, the enzyme addition amount E/S is 0.2-2%, and the enzymolysis time is 2-4h; the heating extraction treatment specifically comprises the following steps: the extraction temperature is 70-80 ℃ and the extraction time is 1-2h; in the steps (1) - (2), the addition amount of the activated carbon is 2-8%, m/v;
in the step (2), water is added for pulping, the solid-to-liquid ratio of the cactus to the water is 1:15-25g/mL, and the mass ratio of the cellulase to the pectase is 1:0.5-1; the enzymolysis treatment specifically comprises the following steps: the enzymolysis temperature is 45-55 ℃, the enzyme addition amount E/S is 0.2-3%, and the enzymolysis time is 2-5h; the pH regulator is at least one selected from citric acid, malic acid and acetic acid; adjusting the pH to 4-6; in the step (2), the heat extraction treatment specifically includes: the extraction temperature is 60-70 ℃ and the extraction time is 1-2h;
in the step (3), the crushing is carried out, and the particle size of the crushing is 50-100 meshes; in the step (3), the decoction is carried out for 2-4 times, the solid-liquid ratio is 1:5-15g/mL, and the time of each decoction is 0.5-2h, so as to obtain rhodiola rosea extract;
in the step (4), the crushing is carried out, and the particle size of the crushing is 50-100 meshes; in the step (4), the volume concentration of the ethanol solution is 45-60%; the solid-to-liquid ratio of the dendrobium candidum stem powder to the ethanol solution is 1:10-20g/mL;
in the step (4), the ultrasonic treatment is carried out for 30-50min, the ultrasonic treatment temperature is 40-60 ℃, and the ultrasonic treatment power is 40-60kHz; in the step (4), the reflux extraction is carried out at the temperature of 45-55 ℃ for 1-3 hours; extracting under reflux for 1 time to obtain Dendrobium officinale stem extract;
in the step (5), the crushing is carried out, and the particle size of the crushing is 150-300 meshes; in the step (5), the water vapor is used for extraction for 3-5 hours to obtain the evening primrose extract.
2. The compound plant extract according to claim 1, which is characterized by comprising the following components in parts by weight: 5-8 parts of aloe extract, 6-9 parts of cactus extract, 8-12 parts of rhodiola rosea extract, 3-5 parts of dendrobium candidum stem extract and 3-5 parts of evening primrose extract.
3. The compound plant extract according to claim 2, which is characterized by comprising the following components in parts by weight: 7 parts of aloe extract, 8 parts of cactus extract, 10 parts of rhodiola rosea extract, 4 parts of dendrobium candidum stem extract and 3.3 parts of evening primrose extract.
4. Use of a compound plant extract in the preparation of a cosmetic with moisturizing and anti-aging effects, characterized in that the compound plant extract in the use is the compound plant extract according to any one of claims 1 to 3.
5. A cosmetic with moisturizing and antiaging effects is characterized by comprising a compound plant extract and raw material auxiliary materials which can be used in the field of cosmetics; the compound plant extract is the compound plant extract of any one of claims 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410028211.XA CN117530895B (en) | 2024-01-09 | 2024-01-09 | Compound plant extract with moisturizing effect and preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410028211.XA CN117530895B (en) | 2024-01-09 | 2024-01-09 | Compound plant extract with moisturizing effect and preparation and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117530895A CN117530895A (en) | 2024-02-09 |
| CN117530895B true CN117530895B (en) | 2024-03-15 |
Family
ID=89790350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410028211.XA Active CN117530895B (en) | 2024-01-09 | 2024-01-09 | Compound plant extract with moisturizing effect and preparation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117530895B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852846A3 (en) * | 2003-03-28 | 2004-10-01 | Michel Frey | Compositions for cosmetic, dermo-cosmetic, pharmaceutical and nutritional purposes having an anti-aging and anti-stress activity, containing an extract of Rhodiola rosea |
| CN104434642A (en) * | 2014-11-14 | 2015-03-25 | 皖南医学院 | Whitening and moisturizing gel for after-sun repairing and preparation method thereof |
| CN107648117A (en) * | 2017-10-31 | 2018-02-02 | 广州赛莱拉干细胞科技股份有限公司 | A kind of whitening spot-removing skin care item and preparation method thereof |
| CN108272719A (en) * | 2018-03-25 | 2018-07-13 | 广州市卓多姿化妆品有限公司 | A kind of whitening spot-removing anti-wrinkle face mask and preparation method thereof |
| CN115137675A (en) * | 2022-08-03 | 2022-10-04 | 珠海远大美业生物科技有限公司 | Compound plant extract with moisturizing effect and application thereof |
-
2024
- 2024-01-09 CN CN202410028211.XA patent/CN117530895B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2852846A3 (en) * | 2003-03-28 | 2004-10-01 | Michel Frey | Compositions for cosmetic, dermo-cosmetic, pharmaceutical and nutritional purposes having an anti-aging and anti-stress activity, containing an extract of Rhodiola rosea |
| CN104434642A (en) * | 2014-11-14 | 2015-03-25 | 皖南医学院 | Whitening and moisturizing gel for after-sun repairing and preparation method thereof |
| CN107648117A (en) * | 2017-10-31 | 2018-02-02 | 广州赛莱拉干细胞科技股份有限公司 | A kind of whitening spot-removing skin care item and preparation method thereof |
| CN108272719A (en) * | 2018-03-25 | 2018-07-13 | 广州市卓多姿化妆品有限公司 | A kind of whitening spot-removing anti-wrinkle face mask and preparation method thereof |
| CN115137675A (en) * | 2022-08-03 | 2022-10-04 | 珠海远大美业生物科技有限公司 | Compound plant extract with moisturizing effect and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117530895A (en) | 2024-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108379168B (en) | Cosmetic for repairing cuticle by plants and preparation method thereof | |
| CN112190509B (en) | Composite plant extract and preparation method and application thereof | |
| CN113208968B (en) | Whitening and moisturizing essence and preparation method thereof | |
| CN110974763A (en) | All-natural plant anti-allergy repair essence and preparation method thereof | |
| CN111374920A (en) | Pure natural hair washing, hair care, moisturizing and repairing composition and preparation method thereof | |
| CN110693780A (en) | Skin nourishing composition and application thereof, and skin nourishing mask liquid | |
| CN110559222B (en) | Moisturizing antioxidant gel and preparation method thereof | |
| CN112043661A (en) | Whitening aloe gel and preparation method thereof | |
| CN113842342B (en) | Plant anti-dandruff antipruritic agent and preparation method and application thereof | |
| CN117530895B (en) | Compound plant extract with moisturizing effect and preparation and application thereof | |
| CN111821230A (en) | Anti-allergy repairing cosmetic composition and application thereof | |
| CN111494290A (en) | Moisturizing mask liquid and preparation method thereof | |
| CN114053186B (en) | Long-acting moisturizing and whitening essence liquid containing roses and preparation method of essence liquid | |
| CN115137675A (en) | Compound plant extract with moisturizing effect and application thereof | |
| CN114732847A (en) | Oil-control anti-alopecia composition, oil-control anti-alopecia product and preparation method thereof | |
| CN114272165A (en) | Whitening and firming plant essence skin care emulsion and preparation method thereof | |
| CN109602653B (en) | Composition, cosmetic and essence with whitening effect and preparation method thereof | |
| CN112842983A (en) | Herbal emulsion for sensitive muscle repair and preparation method thereof | |
| CN112494408A (en) | Whitening and inflammation diminishing mask liquid and preparation method thereof | |
| CN111991267A (en) | Moisturizing and anti-wrinkle eye cream containing rock algae polysaccharide and preparation method thereof | |
| CN111631966A (en) | Essence for moistening and tendering skin and preparation method thereof | |
| CN110946770A (en) | Acne-removing cream with liquid crystal structure and preparation method thereof | |
| CN110882191A (en) | Fermented milk composition and preparation method thereof | |
| CN110856708A (en) | Facial mask liquid and preparation method thereof | |
| CN111904911B (en) | Panax notoginseng-containing plant antioxidant composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |