CN111643441A - Antioxidant whitening moisturizing liquid containing stem cell extracting solution and preparation method thereof - Google Patents
Antioxidant whitening moisturizing liquid containing stem cell extracting solution and preparation method thereof Download PDFInfo
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- CN111643441A CN111643441A CN201910119804.6A CN201910119804A CN111643441A CN 111643441 A CN111643441 A CN 111643441A CN 201910119804 A CN201910119804 A CN 201910119804A CN 111643441 A CN111643441 A CN 111643441A
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- 210000000130 stem cell Anatomy 0.000 title claims abstract description 26
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 25
- 230000002087 whitening effect Effects 0.000 title claims abstract description 25
- 239000007788 liquid Substances 0.000 title claims abstract description 19
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 18
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title description 7
- 239000000284 extract Substances 0.000 claims abstract description 103
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 45
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 claims abstract description 36
- 241000220317 Rosa Species 0.000 claims abstract description 28
- 241000208681 Hamamelis virginiana Species 0.000 claims abstract description 26
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims abstract description 26
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229940109529 pomegranate extract Drugs 0.000 claims abstract description 23
- 244000028419 Styrax benzoin Species 0.000 claims abstract description 18
- 235000000126 Styrax benzoin Nutrition 0.000 claims abstract description 18
- 235000008411 Sumatra benzointree Nutrition 0.000 claims abstract description 18
- 229960002130 benzoin Drugs 0.000 claims abstract description 18
- 229940038487 grape extract Drugs 0.000 claims abstract description 18
- 235000019382 gum benzoic Nutrition 0.000 claims abstract description 18
- 235000020748 rosemary extract Nutrition 0.000 claims abstract description 18
- 229940092258 rosemary extract Drugs 0.000 claims abstract description 18
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 claims abstract description 18
- 210000004027 cell Anatomy 0.000 claims abstract description 14
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 13
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 13
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims abstract description 13
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims abstract description 13
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims abstract description 13
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 13
- 240000005979 Hordeum vulgare Species 0.000 claims abstract description 13
- 235000007340 Hordeum vulgare Nutrition 0.000 claims abstract description 13
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 13
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 13
- 229960000271 arbutin Drugs 0.000 claims abstract description 13
- 229940069780 barley extract Drugs 0.000 claims abstract description 13
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 13
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 13
- 229930007744 linalool Natural products 0.000 claims abstract description 13
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims abstract description 13
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 claims abstract description 13
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims abstract description 13
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 9
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 50
- 238000001914 filtration Methods 0.000 claims description 50
- 239000006228 supernatant Substances 0.000 claims description 45
- 238000010298 pulverizing process Methods 0.000 claims description 35
- 238000002791 soaking Methods 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 229940074410 trehalose Drugs 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 241000219095 Vitis Species 0.000 claims description 10
- 235000009392 Vitis Nutrition 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- 210000000582 semen Anatomy 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 8
- 244000077995 Coix lacryma jobi Species 0.000 claims description 5
- 241000219991 Lythraceae Species 0.000 claims description 5
- 235000014360 Punica granatum Nutrition 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 238000011049 filling Methods 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 239000003208 petroleum Substances 0.000 claims description 5
- 229940042585 tocopherol acetate Drugs 0.000 claims description 4
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000000643 oven drying Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 3
- 206010013663 drug dependence Diseases 0.000 abstract description 2
- 239000000419 plant extract Substances 0.000 abstract description 2
- 230000037394 skin elasticity Effects 0.000 abstract description 2
- 208000011117 substance-related disease Diseases 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 description 3
- 241000208690 Hamamelis Species 0.000 description 2
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an antioxidant whitening moisturizing liquid containing stem cell extracting solution, which comprises the following components in parts by weight: 40-50 parts of dry cell whole extract, 5-10 parts of glycerol, 3-5 parts of butanediol, 1-3 parts of linalool, 1-2 parts of arbutin, 0.5-1 part of Hamamelis virginiana extract, 0.5-1 part of rose extract, 0.5-1 part of rosemary extract, 0.5-1 part of pearl barley extract, 0.5-1 part of benzoin extract, 0.5-1 part of grape extract, 0.5-1 part of pomegranate extract, 0.5-1 part of trehalose, 0.1-0.5 part of sodium ascorbyl phosphate, 0.1-0.5 part of tocopheryl acetate, 0.1-0.5 part of methylisothiazolinone and 0.1-0.3 part of hyaluronic acid. The antioxidant whitening moisturizing liquid disclosed by the invention is prepared by taking a pure natural plant extract as a main functional component and adding glycerol and other components, and is good in stability, free of any side effect, drug dependence and irritation to skin, remarkable in whitening effect, good in skin elasticity after being used, good in moisturizing effect and good in beautifying and skin-care effects.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an antioxidant whitening moisturizing liquid containing a stem cell extracting solution and a preparation method thereof.
Background
Hydration and moisturization of the skin are important factors in maintaining the structural integrity and barrier function of the skin, healthy skin moisture retention is balanced with water evaporation, and pathological processes and environmental factors disrupt this balance, resulting in dry skin. Whitening and moisturizing are cosmetics which are popular with people and play a key role in basic cosmetics, but the whitening and moisturizing liquid sold in the market is irritant to the skin or has an unobvious moisturizing and whitening effect and cannot meet the use requirements of consumers.
Disclosure of Invention
The technical problem to be solved by the invention is to provide an antioxidant whitening and moisturizing liquid containing a stem cell extracting solution, which can solve the problems of large irritation of whitening and moisturizing types or unobvious whitening and moisturizing effects in the prior art. In addition, the invention also provides a preparation method of the antioxidant whitening moisturizing liquid containing the stem cell extracting solution.
In order to solve the problems, the invention adopts the following technical scheme:
the invention provides an antioxidant whitening moisturizing liquid containing stem cell extracting solution, which comprises the following components in parts by weight: 40-50 parts of dry cell whole extract, 5-10 parts of glycerol, 3-5 parts of butanediol, 1-3 parts of linalool, 1-2 parts of arbutin, 0.5-1 part of Hamamelis virginiana extract, 0.5-1 part of rose extract, 0.5-1 part of rosemary extract, 0.5-1 part of pearl barley extract, 0.5-1 part of benzoin extract, 0.5-1 part of grape extract, 0.5-1 part of pomegranate extract, 0.5-1 part of trehalose, 0.1-0.5 part of sodium ascorbyl phosphate, 0.1-0.5 part of tocopheryl acetate, 0.1-0.5 part of methylisothiazolinone and 0.1-0.3 part of hyaluronic acid.
The preferable technical scheme comprises the following components in parts by weight: 45 parts of a dry cell whole extracting solution, 8 parts of glycerol, 4 parts of butanediol, 2 parts of linalool, 1.5 parts of arbutin, 0.8 part of hamamelis virginiana extract, 0.8 part of rose extract, 0.8 part of rosemary extract, 0.8 part of pearl barley extract, 0.8 part of benzoin extract, 0.8 part of grape extract, 0.8 part of pomegranate extract, 0.8 part of trehalose, 0.3 part of sodium ascorbyl phosphate, 0.3 part of tocopherol acetate, 0.3 part of methylisothiazolinone and 0.2 part of hyaluronic acid, wherein the dry cell whole extracting solution is obtained by culturing human skin dry cells for more than 3 days, crushing and centrifuging the whole culture solution mixture of the dry cells, taking supernatant, and filtering the supernatant by a filter membrane.
In a second aspect of the present invention, there is provided a method for preparing an antioxidant whitening moisturizing liquid containing a stem cell extract, for preparing the antioxidant whitening moisturizing liquid, comprising the steps of:
step one, preparing a Hamamelis virginiana extract; drying Hamamelis virginiana, pulverizing, adding petroleum ether, heating in water bath, refluxing for decolorizing for 2 hr, filtering, collecting the residue, adding water, heating, refluxing for extracting for 3 hr, filtering, and collecting the supernatant to obtain Hamamelis virginiana extract.
Preparing a rose extract; pulverizing rose petal, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain rose extract;
preparing rosemary extract; pulverizing herba Rosmarini officinalis, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extract;
preparing a coix seed extract; pulverizing Coicis semen, adding water, decocting, filtering, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain Coicis semen extract;
preparing benzoin extract; pulverizing Benzoinum, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain Benzoinum extract;
preparing a grape extract; oven drying fructus Vitis Viniferae, pulverizing, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain fructus Vitis Viniferae extract;
preparing a pomegranate extract; pulverizing pomegranate, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain pomegranate extract;
and step two, sequentially adding glycerol, butanediol and linalool into the stem cell whole extracting solution, heating and stirring uniformly, then sequentially adding arbutin, hamamelis virginiana extract, rose extract, rosemary extract, pearl barley extract, benzoin extract, grape extract, pomegranate extract, trehalose, sodium ascorbyl phosphate, tocopheryl acetate, methylisothiazolinone and hyaluronic acid, stirring uniformly to obtain a mixture, homogenizing the mixture in a homogenizer, discharging, adding a decolorizing agent, standing, filtering and filling.
As a preferred technical scheme, the decolorizing agent is activated carbon.
The antioxidant whitening moisturizing liquid disclosed by the invention is prepared by taking a pure natural plant extract as a main functional component and adding glycerol and other components, and is good in stability, free of any side effect, drug dependence and irritation to skin, remarkable in whitening effect, good in skin elasticity after being used, good in moisturizing effect and good in beautifying and skin-care effects.
Detailed Description
Example 1
An antioxidant whitening moisturizing liquid containing stem cell extract comprises the following components in parts by weight: 45 g of dry cell whole extract, 8 g of glycerol, 4 g of butanediol, 2 g of linalool, 1.5 g of arbutin, 0.8 g of hamamelis extract, 0.8 g of rose extract, 0.8 g of rosemary extract, 0.8 g of pearl barley extract, 0.8 g of benzoin extract, 0.8 g of grape extract, 0.8 g of pomegranate extract, 0.8 g of trehalose, 0.3 g of sodium ascorbyl phosphate, 0.3 g of tocopheryl acetate, 0.3 g of methylisothiazolinone and 0.2 g of hyaluronic acid.
The preparation method comprises the following steps:
step one, preparing a Hamamelis virginiana extract; drying Hamamelis virginiana, pulverizing, adding petroleum ether, heating in water bath, refluxing for decolorizing for 2 hr, filtering, collecting the residue, adding water, heating, refluxing for extracting for 3 hr, filtering, and collecting the supernatant to obtain Hamamelis virginiana extract.
Preparing a rose extract; pulverizing rose petal, adding 60% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain rose extract;
preparing rosemary extract; pulverizing herba Rosmarini officinalis, adding 60% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extract;
preparing a coix seed extract; pulverizing Coicis semen, adding water, decocting, filtering, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain Coicis semen extract;
preparing benzoin extract; pulverizing Benzonum, adding 60% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain Benzonum extract;
preparing a grape extract; drying fructus Vitis Viniferae, pulverizing, adding 60% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain fructus Vitis Viniferae extract;
preparing a pomegranate extract; pulverizing pomegranate, adding 60% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain pomegranate extract;
the stem cell whole extract is obtained by culturing human skin stem cells for more than 3 days, crushing and centrifuging the whole culture solution mixture of the stem cells, taking supernatant, and filtering the supernatant by a filter membrane.
And step two, sequentially adding glycerol, butanediol and linalool into the stem cell whole extracting solution, heating and stirring uniformly, then sequentially adding arbutin, hamamelis virginiana extract, rose extract, rosemary extract, pearl barley extract, benzoin extract, grape extract, pomegranate extract, trehalose, sodium ascorbyl phosphate, tocopheryl acetate, methylisothiazolinone and hyaluronic acid, stirring uniformly to obtain a mixture, homogenizing the mixture in a homogenizer, discharging, adding a decolorizing agent, standing, filtering and filling. The decolorizing agent is activated carbon.
Example 2
An antioxidant whitening moisturizing liquid containing stem cell extract comprises the following components in parts by weight: 40 g of dry cell whole extract, 10 g of glycerol, 3 g of butanediol, linalool, 1 g of arbutin, 1 g of hamamelis virginiana extract, 0.5 g of rose extract, 1 g of rosemary extract, 0.5 g of pearl barley extract, 1 g of benzoin extract, 0.5 g of grape extract, 1 g of pomegranate extract, 0.5 g of trehalose, 0.5 g of sodium ascorbyl phosphate, 0.1 g of tocopherol acetate, 0.5 g of methylisothiazolinone and 0.1 g of hyaluronic acid.
The preparation method comprises the following steps:
step one, preparing a Hamamelis virginiana extract; drying Hamamelis virginiana, pulverizing, adding petroleum ether, heating in water bath, refluxing for decolorizing for 2 hr, filtering, collecting the residue, adding water, heating, refluxing for extracting for 3 hr, filtering, and collecting the supernatant to obtain Hamamelis virginiana extract.
Preparing a rose extract; pulverizing rose petal, adding 55% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain rose extract;
preparing rosemary extract; pulverizing herba Rosmarini officinalis, adding 55% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extract;
preparing a coix seed extract; pulverizing Coicis semen, adding water, decocting, filtering, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain Coicis semen extract;
preparing benzoin extract; pulverizing Benzonum, adding 55% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain Benzonum extract;
preparing a grape extract; drying fructus Vitis Viniferae, pulverizing, adding 55% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain fructus Vitis Viniferae extract;
preparing a pomegranate extract; pulverizing pomegranate, adding 55% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain pomegranate extract;
the stem cell whole extract is obtained by culturing human skin stem cells for more than 3 days, crushing and centrifuging the whole culture solution mixture of the stem cells, taking supernatant, and filtering the supernatant by a filter membrane.
And step two, sequentially adding glycerol, butanediol and linalool into the stem cell whole extracting solution, heating and stirring uniformly, then sequentially adding arbutin, hamamelis virginiana extract, rose extract, rosemary extract, pearl barley extract, benzoin extract, grape extract, pomegranate extract, trehalose, sodium ascorbyl phosphate, tocopheryl acetate, methylisothiazolinone and hyaluronic acid, stirring uniformly to obtain a mixture, homogenizing the mixture in a homogenizer, discharging, adding a decolorizing agent, standing, filtering and filling. The decolorizing agent is activated carbon.
Example 3
An antioxidant whitening moisturizing liquid containing stem cell extract comprises the following components in parts by weight: 50 g of dry cell whole extract, 5 g of glycerol, 5 g of butanediol, 1 g of linalool, 2 g of arbutin, 0.5 g of hamamelis extract, 1 g of rose extract, 0.5 g of rosemary extract, 1 g of pearl barley extract, 0.5 g of benzoin extract, 1 g of grape extract, 0.5 g of pomegranate extract, 1 g of trehalose, 0.1 g of sodium ascorbyl phosphate, 0.5 g of tocopherol acetate, 0.1 g of methylisothiazolinone and 0.3 g of hyaluronic acid.
The preparation method comprises the following steps:
step one, preparing a Hamamelis virginiana extract; drying Hamamelis virginiana, pulverizing, adding petroleum ether, heating in water bath, refluxing for decolorizing for 2 hr, filtering, collecting the residue, adding water, heating, refluxing for extracting for 3 hr, filtering, and collecting the supernatant to obtain Hamamelis virginiana extract.
Preparing a rose extract; pulverizing rose petal, adding 65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain rose extract;
preparing rosemary extract; pulverizing herba Rosmarini officinalis, adding 65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extract;
preparing a coix seed extract; pulverizing Coicis semen, adding water, decocting, filtering, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain Coicis semen extract;
preparing benzoin extract; pulverizing Benzonum, adding 65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain Benzonum extract;
preparing a grape extract; drying fructus Vitis Viniferae, pulverizing, adding 65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain fructus Vitis Viniferae extract;
preparing a pomegranate extract; pulverizing pomegranate, adding 65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain pomegranate extract;
the stem cell whole extract is obtained by culturing human skin stem cells for more than 3 days, crushing and centrifuging the whole culture solution mixture of the stem cells, taking supernatant, and filtering the supernatant by a filter membrane.
And step two, sequentially adding glycerol, butanediol and linalool into the stem cell whole extracting solution, heating and stirring uniformly, then sequentially adding arbutin, hamamelis virginiana extract, rose extract, rosemary extract, pearl barley extract, benzoin extract, grape extract, pomegranate extract, trehalose, sodium ascorbyl phosphate, tocopheryl acetate, methylisothiazolinone and hyaluronic acid, stirring uniformly to obtain a mixture, homogenizing the mixture in a homogenizer, discharging, adding a decolorizing agent, standing, filtering and filling. The decolorizing agent is activated carbon.
The present invention has been described in terms of specific examples, which are provided to aid understanding of the invention and are not intended to be limiting. For a person skilled in the art to which the invention pertains, several simple deductions, modifications or substitutions may be made according to the idea of the invention.
Claims (4)
1. An antioxidant whitening moisturizing liquid containing stem cell extract is characterized by comprising the following components in parts by weight: 40-50 parts of dry cell whole extract, 5-10 parts of glycerol, 3-5 parts of butanediol, 1-3 parts of linalool, 1-2 parts of arbutin, 0.5-1 part of Hamamelis virginiana extract, 0.5-1 part of rose extract, 0.5-1 part of rosemary extract, 0.5-1 part of pearl barley extract, 0.5-1 part of benzoin extract, 0.5-1 part of grape extract, 0.5-1 part of pomegranate extract, 0.5-1 part of trehalose, 0.1-0.5 part of sodium ascorbyl phosphate, 0.1-0.5 part of tocopheryl acetate, 0.1-0.5 part of methylisothiazolinone and 0.1-0.3 part of hyaluronic acid.
2. The antioxidant whitening moisturizing liquid as claimed in claim 1, which is characterized by comprising the following components in parts by weight: 45 parts of a dry cell whole extracting solution, 8 parts of glycerol, 4 parts of butanediol, 2 parts of linalool, 1.5 parts of arbutin, 0.8 part of hamamelis virginiana extract, 0.8 part of rose extract, 0.8 part of rosemary extract, 0.8 part of pearl barley extract, 0.8 part of benzoin extract, 0.8 part of grape extract, 0.8 part of pomegranate extract, 0.8 part of trehalose, 0.3 part of sodium ascorbyl phosphate, 0.3 part of tocopherol acetate, 0.3 part of methylisothiazolinone and 0.2 part of hyaluronic acid, wherein the dry cell whole extracting solution is obtained by culturing human skin dry cells for more than 3 days, crushing and centrifuging the whole culture solution mixture of the dry cells, taking supernatant, and filtering the supernatant by a filter membrane.
3. A method for preparing the antioxidant whitening moisturizing liquid as claimed in any one of claims 1-2, comprising the following steps:
step one, preparing a Hamamelis virginiana extract; drying Hamamelis virginiana, pulverizing, adding petroleum ether, heating in water bath, refluxing for decolorizing for 2 hr, filtering, collecting the residue, adding water, heating, refluxing for extracting for 3 hr, filtering, and collecting the supernatant to obtain Hamamelis virginiana extract.
Preparing a rose extract; pulverizing rose petal, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain rose extract;
preparing rosemary extract; pulverizing herba Rosmarini officinalis, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain herba Rosmarini officinalis extract;
preparing a coix seed extract; pulverizing Coicis semen, adding water, decocting, filtering, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain Coicis semen extract;
preparing benzoin extract; pulverizing Benzoinum, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain Benzoinum extract;
preparing a grape extract; oven drying fructus Vitis Viniferae, pulverizing, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain fructus Vitis Viniferae extract;
preparing a pomegranate extract; pulverizing pomegranate, adding 55-65% ethanol solution, soaking, ultrasonic extracting, filtering, centrifuging the filtrate, collecting supernatant, and concentrating under reduced pressure to obtain pomegranate extract;
and step two, sequentially adding glycerol, butanediol and linalool into the stem cell whole extracting solution, heating and stirring uniformly, then sequentially adding arbutin, hamamelis virginiana extract, rose extract, rosemary extract, pearl barley extract, benzoin extract, grape extract, pomegranate extract, trehalose, sodium ascorbyl phosphate, tocopheryl acetate, methylisothiazolinone and hyaluronic acid, stirring uniformly to obtain a mixture, homogenizing the mixture in a homogenizer, discharging, adding a decolorizing agent, standing, filtering and filling.
4. The method for preparing the antioxidant type whitening and moisturizing liquid as claimed in claim 3, wherein the decolorizing agent is activated carbon.
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CN114272193A (en) * | 2021-11-05 | 2022-04-05 | 杭州爱唯生命科技有限公司 | Cosmetic composition containing stem cell extracting solution and preparation method thereof |
CN116115543A (en) * | 2022-12-28 | 2023-05-16 | 欧诗漫生物股份有限公司 | Method for extracting active ingredient from plant and plant extract |
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CN114272193A (en) * | 2021-11-05 | 2022-04-05 | 杭州爱唯生命科技有限公司 | Cosmetic composition containing stem cell extracting solution and preparation method thereof |
CN116115543A (en) * | 2022-12-28 | 2023-05-16 | 欧诗漫生物股份有限公司 | Method for extracting active ingredient from plant and plant extract |
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