CN105287341A - Whitening moisture-retention essence and preparation method thereof - Google Patents
Whitening moisture-retention essence and preparation method thereof Download PDFInfo
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- CN105287341A CN105287341A CN201510799279.9A CN201510799279A CN105287341A CN 105287341 A CN105287341 A CN 105287341A CN 201510799279 A CN201510799279 A CN 201510799279A CN 105287341 A CN105287341 A CN 105287341A
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- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
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- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and concretely relates to a whitening moisture-retention essence and a preparation method thereof. The whitening-retention essence comprises the following raw materials in parts by weight: 0.2-0.5 parts of a thickening agent, 3-12 parts of polyol, 15-35 parts of a traditional Chinese medicine extract product, 1-2 parts of honey, 0.3-2 parts of pearl powder, 0.1-0.3 parts of essence and 40-70 parts of water. The preparation raw materials of a traditional Chinese medicine extract product comprise eucommia, seeds of Job's tears and blueberry fruit. The whitening moisture-retention essence has the advantages of good permeability and easy absorption, and has the efficacy for whitening and keeping moisture, restoring skin wrinkles, improving dark skin, enhancing skin luster and delaying skin aging.
Description
Technical field
The present invention relates to cosmetic technical field, be specifically related to a kind of whitening skin and preserving moisture essence and preparation method thereof.
Background technology
Whitening be always consumer to two of cosmetics large major function demands, particularly domestic market, one hides in vain hundred ugly traditional views allows the demand of consumer to whitening product reach ultimate attainment especially.Along with the raising of living standards of the people and aesthetical standard, the skin of pale and clean profit more and more praise highly by most of women.By the use of Skin whitening care cosmetics, Asians can obtain fair, bright and clean skin.China's Chinese herbal treatment and the various dermatosis of nursing have the history of several thousand.In recent years, for to the toxicity of chemical toilet and irritating doubt, increasing scientific researcher tends to find whitening active material safely and efficiently from natural plants, thus develop whitening effect obviously, action temperature and, the cosmetics of nontoxic non-irritating Chinese herbal medicine and natural plant composition.At present, most of whitening product is all adopt the chemical composition such as arbutin, hydroquinone to realize whitening, but this kind of Product Safety is poor, has stimulation to human body, and effect is undesirable, gradually by replacement slowly.
Chinese patent application 201510117946.0 discloses a kind of cleawhite over-night essences and preparation method thereof, this cleawhite over-night essences comprises Margarita powder, Margarita extract, Glycyrrhiza glabra L. aqueous solution, hydrolysis conchiolin, Semen Pisi sativi extract, glycerol, AVC, xanthan gum and hyaluronate sodium, be zero when Margarita powder is different with the content of Margarita extract, and the percentage composition of Glycyrrhiza glabra L. extract is 0.5 ~ 5.0% in Glycyrrhiza glabra L. aqueous solution, this cleawhite over-night essences improves the barrier function of skin in certain degree, skin care, increase the degree of hydration of skin, but its poor permeability, not easily absorb, and whitening skin and preserving moisture effect is not remarkable.
Therefore, be necessary to research and develop a kind of good penetrability, easily absorb, whitening effect moisturizing, improves skin obscure, improves skin glossy, the whitening skin and preserving moisture essence of delay skin aging.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of whitening skin and preserving moisture essence, this whitening skin and preserving moisture essence good penetrability, easily absorbs, has effect whitening skin and preserving moisture, improve skin obscure, improves skin glossy, effect of delay skin aging.
To achieve these goals, technical scheme of the present invention is as follows:
A kind of whitening skin and preserving moisture essence, comprise the raw material of following parts by weight: thickening agent 0.2 ~ 0.5 part, polyhydric alcohol 3 ~ 12 parts, Chinese medicine extract 15 ~ 35 parts, Mel 1 ~ 2 part, Margarita powder 0.3 ~ 2 part, 0.1 ~ 0.3 part, essence and 40 ~ 70 parts, water, the raw materials of described Chinese medicine extract comprises the Cortex Eucommiae, Radix Asparagi, Semen Coicis and blue berry.
Preferably, described polyhydric alcohol is selected from least one in glycerol and sorbitol, and described thickening agent is selected from hydroxyethyl-cellulose.
Preferably, the raw materials of described Chinese medicine extract is made up of the Cortex Eucommiae, Radix Asparagi, Semen Coicis and the blue berry weight ratio according to 4 ~ 8:4 ~ 8:4 ~ 8:4 ~ 8.
Preferably, described whitening skin and preserving moisture essence is made up of the raw material of following parts by weight: thickening agent 0.3 part, polyhydric alcohol 9 parts, Chinese medicine extract 20 parts, Mel 1 part, Margarita powder 1 part, 0.2 part, essence and 60 parts, water.
Preferably, described whitening skin and preserving moisture essence also comprises antiseptic 0.1 ~ 1 part.
Preferably, described Chinese medicine extract is obtained by following steps:
S1: get the Cortex Eucommiae, Radix Asparagi and Semen Coicis, drying and crushing, add the water soaking 40 ~ 60 minutes of medical material gross weight 8 ~ 12 times amount, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filters and retains filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 6-10 times amount volume fraction in the filtering residue in S1 is the ethanol of 75 ~ 90%, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 ~ 24 hours, centrifugal 10 ~ 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 20 ~ 40 DEG C, material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.10 ~ 0.25MPa, when feed liquid stock solution reduces 1/9 ~ 1/4, then the ultrafiltration 1 ~ 2 time that adds water, merge ultrafiltrate;
S4: be the extractum A of 1.10 ~ 1.25 by relative density at ultrafiltrate vacuum-concentrcted to 60 DEG C, for subsequent use;
S5: get blue berry making beating, obtain blue berry serosity, add 6 ~ 12 times amount 60 ~ 75% ethanol, ultrasonic extraction 2 ~ 3 times, each 25 ~ 40 minutes, sucking filtration, centrifugal, decompression recycling ethanol, is concentrated into the extractum B that relative density at 60 DEG C is 1.10 ~ 1.25 by filtrate, for subsequent use;
S6: merge extractum A and extractum B, obtain described Chinese medicine extract.
Present invention also offers the preparation method of above-mentioned whitening skin and preserving moisture essence, specifically comprise the following steps:
S1: thickening agent and polyhydric alcohol are added in oil phase pot, is heated to 70 ~ 85 DEG C, is stirred to and dissolves completely, obtain material A;
S2: water, Mel and Margarita powder are added in aqueous phase pot, is heated to 70 ~ 85 DEG C, is stirred to and dissolves completely, obtains material B;
S3: by material A and material B suction emulsifying pot, opens homogenizing, homogenizing 3 ~ 8min, insulated and stirred 15 ~ 20min;
S4: be cooled to 40 ~ 45 DEG C, adds described Chinese medicine extract, essence and antiseptic, stirs, get final product discharging, obtained whitening skin and preserving moisture essence.
Preferably, described Chinese medicine extract is obtained by following steps:
S1: get the Cortex Eucommiae, Radix Asparagi and Semen Coicis, drying and crushing, add the water soaking 40 ~ 60 minutes of medical material gross weight 8 ~ 12 times amount, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filters and retains filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 6-10 times amount volume fraction in the filtering residue in S1 is the ethanol of 75 ~ 90%, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 ~ 24 hours, centrifugal 10 ~ 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 20 ~ 40 DEG C, material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.10 ~ 0.25MPa, when feed liquid stock solution reduces 1/9 ~ 1/4, then the ultrafiltration 1 ~ 2 time that adds water, merge ultrafiltrate;
S4: be the extractum A of 1.10 ~ 1.25 by relative density at ultrafiltrate vacuum-concentrcted to 60 DEG C, for subsequent use;
S5: get blue berry making beating, obtain blue berry serosity, add 6 ~ 12 times amount 60 ~ 75% ethanol, ultrasonic extraction 2 ~ 3 times, each 25 ~ 40 minutes, sucking filtration, centrifugal, decompression recycling ethanol, is concentrated into the extractum B that relative density at 60 DEG C is 1.10 ~ 1.25 by filtrate, for subsequent use;
S6: merge extractum A and extractum B, obtain described Chinese medicine extract.
In technical solution of the present invention, described Cortex Eucommiae extract is rich in the unsaturated fatty acid such as linolenic acid, linoleic acid, can safeguard the nutritive equilibrium of cell membrane, resists the infringement of external environment to skin, makes skin present efficient regeneration, moisturizing, the daily life function such as penetrating; Increase cell membrane elasticity and activating cell, improve the quality of epidermal area, reduce the deposition of pigment, skin care, improves coarse, the obscure skin without light quality.Non-oxidizability is strong, can effectively in and free radical, enhance metabolism, reduce visible microgroove.
Described Semen Coicis obtains rich in protein and vitamin through extracting, and skin can be made delicate fine and smooth, eliminating mottle with reducing wrinkle, eliminating pigment, thus improving the texture of skin, color and luster and brightness.
Aspartic acid contained by described Radix Asparagi has non-oxidizability, can stop the oxidation of unsaturated fatty acid, delays and treat the keratinization of skin, keeps the soft and smooth and moistening of skin, makes skin water tender flexible.
Described Margarita powder is the good nutritive effect composition of one of human body skin.It can improve the barrier function of skin, can also skin care, increases the degree of hydration of skin, goes out inhibitory action significantly to the activities present of tryrosinase.Further, there are some researches show that Margarita powder has very strong suppression and removes the ability of free radical.
The anthocyanidin that described blue berry is rich in is the anti-aging and nutritive supplement of pure natural, and its non-oxidizability is strong, can effectively in and free radical, promotion skin metabolism.
Whitening skin and preserving moisture essence of the present invention contains the Cortex Eucommiae, Radix Asparagi, Semen Coicis and blue berry Four Plants composition, again in conjunction with basic materials such as thickening agent of the present invention, polyhydric alcohol, essence, water, each component is worked in coordination with, and makes whitening skin and preserving moisture essence good penetrability of the present invention, easily absorbs, deep layer whitening skin and preserving moisture, nourish maintenance skin, promote cell metabolism, improve the obscure phenomenon of skin, improve skin brightness and gloss, make skin keep water tender smooth.
Therefore, compared with prior art, advantage of the present invention is:
(1) whitening skin and preserving moisture essence of the present invention contains the Cortex Eucommiae, Radix Asparagi, Semen Coicis and blue berry Four Plants composition, can reach efficient whitening, moisturizing, promotes skin metabolism, improve skin obscure, improve skin glossy, skin beauty water is moistened smooth, high resilience, promotes skin year slight.
(2) whitening skin and preserving moisture essence safety and stability of the present invention, good penetrability, easily absorbs, and uses rear face salubrious not sticky; And the preparation method of whitening skin and preserving moisture essence of the present invention is simple, condition is controlled, process stabilizing, can be applicable.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, whitening skin and preserving moisture essence of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
the component (with weight parts) of the embodiment of the present invention 1 ~ 3 whitening skin and preserving moisture essence
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Hydroxyethyl-cellulose | 0.2 | 0.5 | 0.3 |
| Glycerol | 1 | 5 | 3 |
| Sorbitol | 2 | 7 | 4 |
| Chinese medicine extract | 14 | 20 | 22 |
| Mel | 1 | 2 | 2 |
| Margarita powder | 0.3 | 2 | 1 |
| Essence | 0.1 | 0.3 | 0.2 |
| Antiseptic | 0.2 | 1 | 0.5 |
| Water | 40 | 70 | 50 |
the component (with weight parts) of comparative example 1 ~ 2 whitening skin and preserving moisture essence
| Component | Comparative example 1 | Comparative example 2 |
| Hydroxyethyl-cellulose | 0.2 | 0.2 |
| Glycerol | - | 1 |
| Sorbitol | 2 | 2 |
| Chinese medicine extract | 14 | 12 |
| Mel | 1 | 1 |
| Margarita powder | 0.3 | 0.3 |
| Essence | 0.1 | 0.1 |
| Antiseptic | 0.2 | 0.2 |
| Water | 40 | 40 |
the preparation method of embodiment 4, the embodiment of the present invention 1 whitening skin and preserving moisture essence:
S1: get the Cortex Eucommiae 6 parts, Radix Asparagi 4 parts and Semen Coicis 4 parts, drying and crushing, add the water soaking 40 minutes of medical material gross weight 8 times amount, reflux, extract, 2 times, each 4 hours, filters and retains filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 6 times amount volume fraction in the filtering residue in S1 is the ethanol of 75%, reflux, extract, 2 times, each 3 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 hours, centrifugal 10 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 25 DEG C, material liquid pH is 6, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.15MPa, when feed liquid stock solution reduces 1/9, then the ultrafiltration 1 time that adds water, merge ultrafiltrate;
S4: be the extractum A of 1.15 by relative density at ultrafiltrate vacuum-concentrcted to 60 DEG C, for subsequent use;
S5: get blue berry 4 parts making beating, obtain blue berry serosity, adds 6 times amount 60% ethanol, ultrasonic extraction 2 times, each 25 minutes, sucking filtration, centrifugal, and filtrate is concentrated into the extractum B that relative density at 60 DEG C is 1.15 by decompression recycling ethanol, for subsequent use;
S6: merge extractum A and extractum B, obtain described Chinese medicine extract;
S7: hydroxyethyl-cellulose, glycerol and sorbitol are added in oil phase pot, is heated to 70 DEG C, is stirred to and dissolves completely, obtain material A;
S8: water, Mel and Margarita powder are added in aqueous phase pot, is heated to 70 DEG C, is stirred to and dissolves completely, obtains material B;
S9: by material A and material B suction emulsifying pot, opens homogenizing, homogenizing 3min, insulated and stirred 15min;
S10: be cooled to 40 DEG C, adds described Chinese medicine extract and essence, stirs, get final product discharging, obtained whitening skin and preserving moisture essence.
the preparation method of embodiment 5, the embodiment of the present invention 2 whitening skin and preserving moisture essence:
S1: get the Cortex Eucommiae 8 parts, Radix Asparagi 6 parts and Semen Coicis 6 parts, drying and crushing, add the water soaking 50 minutes of medical material gross weight 10 times amount, reflux, extract, 3 times, each 5 hours, filters and retains filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 8 times amount volume fraction in the filtering residue in S1 is the ethanol of 80%, reflux, extract, 3 times, each 5 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 hours, centrifugal 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 40 DEG C, material liquid pH is 7, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.2MPa, when feed liquid stock solution reduces 1/6, then the ultrafiltration 1 time that adds water, merge ultrafiltrate;
S4: be the extractum A of 1.20 by relative density at ultrafiltrate vacuum-concentrcted to 60 DEG C, for subsequent use;
S5: get blue berry 6 parts making beating, obtain blue berry serosity, adds 12 times amount 75% ethanol, ultrasonic extraction 2 times, each 30 minutes, sucking filtration, centrifugal, and filtrate is concentrated into the extractum B that relative density at 60 DEG C is 1.10 by decompression recycling ethanol, for subsequent use;
S6: merge extractum A and extractum B, obtain described Chinese medicine extract;
S7: hydroxyethyl-cellulose, glycerol and sorbitol are added in oil phase pot, is heated to 75 DEG C, is stirred to and dissolves completely, obtain material A;
S8: water, Mel and Margarita powder are added in aqueous phase pot, is heated to 75 DEG C, is stirred to and dissolves completely, obtains material B;
S9: by material A and material B suction emulsifying pot, opens homogenizing, homogenizing 5min, insulated and stirred 18min;
S10: be cooled to 40 DEG C, adds described Chinese medicine extract, essence and antiseptic, stirs, get final product discharging, obtained whitening skin and preserving moisture essence.
the preparation method of embodiment 6, the embodiment of the present invention 3 whitening skin and preserving moisture essence:
S1: get the Cortex Eucommiae 8 parts, Radix Asparagi 6 parts and Semen Coicis 8 parts, drying and crushing, add the water soaking 60 minutes of medical material gross weight 12 times amount, reflux, extract, 2 times, each 7 hours, filters and retains filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 10 times amount volume fraction in the filtering residue in S1 is the ethanol of 90%, reflux, extract, 2 times, each 7 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 24 hours, centrifugal 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 35 DEG C, material liquid pH is 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.25MPa, when feed liquid stock solution reduces 1/4, then the ultrafiltration 2 times that adds water, merge ultrafiltrate;
S4: be the extractum A of 1.25 by relative density at ultrafiltrate vacuum-concentrcted to 60 DEG C, for subsequent use;
S5: get blue berry 8 parts making beating, obtain blue berry serosity, adds 6 ~ 12 times amount 75% ethanol, ultrasonic extraction 3 times, each 40 minutes, sucking filtration, centrifugal, and filtrate is concentrated into the extractum B that relative density at 60 DEG C is 1.10 by decompression recycling ethanol, for subsequent use;
S6: merge extractum A and extractum B, obtain described Chinese medicine extract;
S7: hydroxyethyl-cellulose, glycerol and sorbitol are added in oil phase pot, is heated to 85 DEG C, is stirred to and dissolves completely, obtain material A;
S8: water, Mel and Margarita powder are added in aqueous phase pot, is heated to 85 DEG C, is stirred to and dissolves completely, obtains material B;
S9: by material A and material B suction emulsifying pot, opens homogenizing, homogenizing 8min, insulated and stirred 20min;
S10: be cooled to 45 DEG C, adds described Chinese medicine extract, essence and antiseptic, stirs, get final product discharging, obtained whitening skin and preserving moisture essence.
The preparation method reference example 1 of comparative example 1 ~ 2.
Through inspection, the whitening skin and preserving moisture essence that the embodiment of the present invention 1 ~ 3 obtains meets the pertinent regulations requirement of QB/T2660-2004, sense index (color and luster, fragrance, structure) meets industry regulation, and physical and chemical index (pH, heat-resisting, cold-resistant, active matter) meets industry regulation.
test example one, Product Safety evaluation (experiment of human body skin patch)
One, trial target: the whitening skin and preserving moisture essence that embodiment 1 ~ 3, comparative example 1 ~ 2 prepare.
Tested crowd's number: 50 people, women.
Age: between 26 ~ 50 years old.
Health status: subjects skin is healthy, without dermatosis allergies, meets experimenter and volunteers inclusion criteria.
Grouping: 5 groups, often organize 10 people, 27 ± 2 years old mean age.
Two, patch method: select qualified speckle examination device, with closed patch experiment method, tested material being about 0.015mL ~ 0.025mL drips in speckle examination device, external special adhesive tape is covered on experimenter back, tested material is removed after 24 hours, within after removing respectively 0.5,6,12,24,48 hour, observe dermoreaction, according to its result of dermoreaction grade scale record in " cosmetics health specification ".
Three, experimental result: human skin patch result shows: each group experimenter is by the patch test of the whitening skin and preserving moisture essence of embodiment 1 ~ 3, comparative example 1 ~ 2, dermoreaction is observed at 0.5,6,12,24,48 hour, wherein there is skin adverse reaction in 0 example, the whitening skin and preserving moisture essence use safety described in explanation.
test example two, product effect assessment
part I:
One, trial target: embodiment 1 ~ 3, whitening skin and preserving moisture essence prepared by comparative example 1 ~ 2.
Two, tested crowd
Sex number: female, 200 people.
Age: between 30 ~ 50 years old.
Health status: subjects skin is healthy, without dermatosis allergies, meets experimenter and volunteers inclusion criteria.
Grouping: be divided into 5 groups, often organize 40 people, 35 ± 2 years old mean age.
Method of testing: respectively use-case 1 ~ 3, whitening skin and preserving moisture essence prepared by comparative example 1 ~ 2, observes and experiences result of use.Using method: after experimenter cleans face, get appropriate above-mentioned whitening skin and preserving moisture essence in the centre of the palm, uniform application is in face, and be massaged into absorption gently, the every day of each use sooner or later once, adhere to use one month, at least check weekly once to understand with or without whole body and local untoward reaction, and itemized record result.
Four, testing evaluation result is as follows:
(one month) on probation feedback conclusive table of table 1 embodiment 1 whitening skin and preserving moisture essence
(one month) on probation feedback conclusive table of table 2 embodiment 2 whitening skin and preserving moisture essence
(one month) on probation feedback conclusive table of table 3 embodiment 3 whitening skin and preserving moisture essence
(one month) on probation feedback conclusive table of table 4 comparative example 1 whitening skin and preserving moisture essence
(one month) on probation feedback conclusive table of table 5 comparative example 2 whitening skin and preserving moisture essence
From upper table 1 ~ 5, whitening skin and preserving moisture essence the liking and approving extensively by experimenter of the embodiment of the present invention 1 ~ 3, experimenter all represents whitening skin and preserving moisture essence good penetrability of the present invention, easy absorption, uses rear face salubrious not sticky, and whitening, moistening effect are good, promote skin metabolism, and long-acting moisturizing, skin beauty water is moistened smooth, flexible; Wherein the degree of recognition of embodiment 1 whitening skin and preserving moisture essence is the highest, therefore embodiment 1 is preferred embodiment, comparative example 1 and comparative example 2 essence lack some component in whitening skin and preserving moisture essence formula of the present invention, its result of use is all not as embodiment 1 ~ 3, illustrate that whitening skin and preserving moisture essence formula of the present invention is not obtained by the simple combination of each component, then further illustrate between each component of formula of the present invention and there is synergism.There is not people to occur allergic phenomena in whole experimenter simultaneously, all do not occur the situations such as skin pruritus, twinge, redness yet.Therefore, the gentle safety of whitening skin and preserving moisture essence of the present invention, can life-time service.
part II: the whitening effect of whitening skin and preserving moisture essence of the present invention
One, trial target: the whitening skin and preserving moisture essence that embodiment 1,2,3 prepares.
Two, method of testing:
Matched group: commercial whitening agent arbutin;
Test group 1: the whitening skin and preserving moisture essence that the embodiment of the present invention 1 is obtained;
Test group 2: the whitening skin and preserving moisture essence that the embodiment of the present invention 2 is obtained;
Test group 3: the whitening skin and preserving moisture essence that the embodiment of the present invention 3 is obtained.
1) preparation of matched group solution to be measured: get commercial whitening agent arbutin 1g in 10ml beaker, add a small amount of distilled water, be stirred to arbutin and fully dissolve, continues to add distilled water to 10ml.
2) preparation of test group solution to be measured: get the present embodiment 1,2,3 whitening skin and preserving moisture essence 1g respectively in 3 10ml beakers, respectively add a small amount of distilled water, be stirred to essence and fully dissolve, continues to add distilled water to 10ml.
3) preparation of base soln: the 0.2mol/lPBS(phosphate buffer preparing 100u/ml tyrosinase solution, 2.0mmol/lL-tyrosine solution and pH=6.8 respectively) solution based on solution.
4) get 4 test tube accordings to the form below and quantitatively add each base soln and test group solution to be measured, shake up;
| Test tube number | 1 | 2 | 3 | 4 |
| L-tyrosine solution (ml) | 0.50 | 0 | 0.50 | 0 |
| Test group solution to be measured (ml) | 0 | 0 | 0.50 | 0.5 |
| PBS solution (ml) | 2.00 | 2.50 | 2.00 | 2.50 |
| Tyrosinase solution (ml) | 0.50 | 0.50 | 0.50 | 0.50 |
| Absorbance | A1 | A2 | A3 | A4 |
5) 1,2,3, No. 4 test tube is placed in the heating of 310K water-bath after 60 minutes, adopts visible spectrophotometric instrument to measure its absorbance under wavelength 475nm respectively, according to following computing formula:
Tyrosinase inhibition rate (%)=[1-(A3-A4)/(A1-A2)] × 100%
Calculate the solution to be measured of this concentration to the suppression ratio of tryrosinase;
6) step 4) and 5 is repeated), measure matched group solution to be measured to the suppression ratio of tryrosinase.
Four, test result is as table 6.
Table 6 whitening skin and preserving moisture essence whitening effect table with test results
| Group | Test group 1 | Test group 2 | Test group 3 | Matched group |
| Tyrosinase inhibition rate (%) | 74.6 | 68.5 | 66.2 | 64.6 |
TYR (analytical pure), purchased from Solarbio company; Tryrosinase (analytical pure), available from Sigma; Sodium hydrogen phosphate (analytical pure), purchased from Chemical Reagent Co., Ltd., Sinopharm Group; Sodium dihydrogen phosphate (analytical pure), purchased from Chemical Reagent Co., Ltd., Sinopharm Group.
As seen from the above table: the embodiment of the present invention 1,2,3 is under visible spectrophotometric instrument wavelength 475nm, record absorbance as calculated the suppression ratio of whitening skin and preserving moisture essence to tryrosinase of the embodiment of the present invention 1,2,3 is respectively 74.6%, 68.5%, 66.2%, wherein the whitening effect of embodiment 1 whitening skin and preserving moisture essence is best, and the suppression ratio of commercial arbutin to tryrosinase is only 64.6%, visible whitening skin and preserving moisture essence of the present invention has more significant whitening effect compared with commercial arbutin.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all without prejudice under spirit of the present invention and category, can modify above-described embodiment or changes.Therefore, such as have in art usually know the knowledgeable do not depart from complete under disclosed spirit and technological thought all equivalence modify or change, must be contained by claim of the present invention.
Claims (8)
1. a whitening skin and preserving moisture essence, it is characterized in that, comprise the raw material of following parts by weight: thickening agent 0.2 ~ 0.5 part, polyhydric alcohol 3 ~ 12 parts, Chinese medicine extract 15 ~ 35 parts, Mel 1 ~ 2 part, Margarita powder 0.3 ~ 2 part, 0.1 ~ 0.3 part, essence and 40 ~ 70 parts, water, the raw materials of described Chinese medicine extract comprises the Cortex Eucommiae, Radix Asparagi, Semen Coicis and blue berry.
2. whitening skin and preserving moisture essence as claimed in claim 1, it is characterized in that, described polyhydric alcohol is selected from least one in glycerol and sorbitol, and described thickening agent is selected from hydroxyethyl-cellulose.
3. whitening skin and preserving moisture essence as claimed in claim 1, it is characterized in that, the raw materials of described Chinese medicine extract is made up of the Cortex Eucommiae, Radix Asparagi, Semen Coicis and the blue berry weight ratio according to 4 ~ 8:4 ~ 8:4 ~ 8:4 ~ 8.
4. whitening skin and preserving moisture essence as claimed in claim 1, is characterized in that, be made up of the raw material of following parts by weight: thickening agent 0.3 part, polyhydric alcohol 9 parts, Chinese medicine extract 20 parts, Mel 1 part, Margarita powder 1 part, 0.2 part, essence and 60 parts, water.
5. the whitening skin and preserving moisture essence as described in any one of claim 1 ~ 4, is characterized in that, described whitening skin and preserving moisture essence also comprises antiseptic 0.1 ~ 1 part.
6. whitening skin and preserving moisture essence as claimed in claim 1, it is characterized in that, described Chinese medicine extract is obtained by following steps:
S1: get the Cortex Eucommiae, Radix Asparagi and Semen Coicis, drying and crushing, add the water soaking 40 ~ 60 minutes of medical material gross weight 8 ~ 12 times amount, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filters and retains filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 6-10 times amount volume fraction in the filtering residue in S1 is the ethanol of 75 ~ 90%, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 ~ 24 hours, centrifugal 10 ~ 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 20 ~ 40 DEG C, material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.10 ~ 0.25MPa, when feed liquid stock solution reduces 1/9 ~ 1/4, then the ultrafiltration 1 ~ 2 time that adds water, merge ultrafiltrate;
S4: be the extractum A of 1.10 ~ 1.25 by relative density at ultrafiltrate vacuum-concentrcted to 60 DEG C, for subsequent use;
S5: get blue berry making beating, obtain blue berry serosity, add 6 ~ 12 times amount 60 ~ 75% ethanol, ultrasonic extraction 2 ~ 3 times, each 25 ~ 40 minutes, sucking filtration, centrifugal, decompression recycling ethanol, is concentrated into the extractum B that relative density at 60 DEG C is 1.03 ~ 1.10 by filtrate, for subsequent use;
S6: merge extractum A and extractum B, obtain described Chinese medicine extract.
7. the preparation method of whitening skin and preserving moisture essence as claimed in claim 1, is characterized in that, comprise the following steps:
S1: thickening agent and polyhydric alcohol are added in oil phase pot, is heated to 70 ~ 85 DEG C, is stirred to and dissolves completely, obtain material A;
S2: water, Mel and Margarita powder are added in aqueous phase pot, is heated to 70 ~ 85 DEG C, is stirred to and dissolves completely, obtains material B;
S3: by material A and material B suction emulsifying pot, opens homogenizing, homogenizing 3 ~ 8min, insulated and stirred 15 ~ 20min;
S4: be cooled to 40 ~ 45 DEG C, adds described Chinese medicine extract, essence and antiseptic, stirs, get final product discharging, obtained whitening skin and preserving moisture essence.
8. the preparation method of whitening skin and preserving moisture essence as claimed in claim 7, it is characterized in that, described Chinese medicine extract is obtained by following steps:
S1: get the Cortex Eucommiae, Radix Asparagi and Semen Coicis, drying and crushing, add the water soaking 40 ~ 60 minutes of medical material gross weight 8 ~ 12 times amount, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filters and retains filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 6-10 times amount volume fraction in the filtering residue in S1 is the ethanol of 75 ~ 90%, reflux, extract, 2 ~ 3 times, each 3 ~ 8 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 ~ 24 hours, centrifugal 10 ~ 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 20 ~ 40 DEG C, material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.10 ~ 0.25MPa, when feed liquid stock solution reduces 1/9 ~ 1/4, then the ultrafiltration 1 ~ 2 time that adds water, merge ultrafiltrate;
S4: be the extractum A of 1.10 ~ 1.25 by relative density at ultrafiltrate vacuum-concentrcted to 60 DEG C, for subsequent use;
S5: get blue berry making beating, obtain blue berry serosity, add 6 ~ 12 times amount 60 ~ 75% ethanol, ultrasonic extraction 2 ~ 3 times, each 25 ~ 40 minutes, sucking filtration, centrifugal, decompression recycling ethanol, is concentrated into the extractum B that relative density at 60 DEG C is 1.10 ~ 1.25 by filtrate, for subsequent use;
S6: merge extractum A and extractum B, obtain described Chinese medicine extract.
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