CN109125239B - Compound traditional Chinese medicine whitening skin cream and preparation method thereof - Google Patents
Compound traditional Chinese medicine whitening skin cream and preparation method thereof Download PDFInfo
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- CN109125239B CN109125239B CN201811237051.0A CN201811237051A CN109125239B CN 109125239 B CN109125239 B CN 109125239B CN 201811237051 A CN201811237051 A CN 201811237051A CN 109125239 B CN109125239 B CN 109125239B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses a compound traditional Chinese medicine whitening skin cream which is prepared from the following raw materials in parts by weight: 16-24 parts of pseudo-ginseng, 6-14 parts of caulis spatholobi, 7-13 parts of lonicera confusa, 7-13 parts of leech, 16-24 parts of lucid ganoderma, 16-24 parts of dried orange peel, 6-15 parts of pearl barley, 14-20 parts of wormwood, 8-13 parts of ginkgo kernel, 8-13 parts of angelica, 3-5 parts of pearl powder, 18-23 parts of mulberry oil, 3-5 parts of honey, 5-7 parts of lemon juice, 3-5 parts of carrot juice, 8-11 parts of glycerol and 50-80 parts of PEG. The synergistic effect of the saponin in the pseudo-ginseng, the polypeptide in the lucid ganoderma and the synephrine in the dried orange peel can inhibit the generation of melanin, so that spots can disappear quickly, and the skin is ruddy, white and glossy; the skin cream has the components of pure traditional Chinese medicines and plant formulas, is safe and pollution-free, has lasting effect, and has no toxic or side effect after long-term use.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a compound traditional Chinese medicine whitening skin cream and a preparation method thereof.
Background
With the progress of society and the improvement of living standard of people, beauty cosmetics become indispensable beauty elements in life, and green and natural beauty cosmetics also become the exploration theme of cosmetics. However, there are a lot of messy whitening products in the market, and some of them are illegal to add a large amount of chemicals harmful to human body into skin care products in order to achieve the effect of whitening and repairing skin, and even add limited or forbidden chemicals containing medicinal hormones and the like into skin care products. However, the long-term use of these harmful substances causes serious harm to human body.
The consumption concept of people is also changed greatly, the pure natural active cosmetics conform to the trend of returning to nature and the consumption psychology of people, and especially, the cosmetics added with the effective components of the traditional Chinese medicines have wide prospects. Meanwhile, cosmetics containing traditional Chinese medicine active ingredients are more and more favored by consumers due to the characteristics of high drug effect, small side effect and no toxicity. Abundant medicinal resources are a treasure house of Chinese traditional medicines, people who work for thousands of years accumulate a lot of natural medicinal experience, and cosmetics added with Chinese herbal medicine extracts are treasure of Chinese nations, have stable medicinal properties and lasting medicinal efficacy, and have mild effect on skin, small irritation, high safety and obvious curative effect. The research on the whitening skin care product which is safe and reliable and has multiple skin care effects is a hot spot in the field.
Disclosure of Invention
An object of the present invention is to solve at least the above problems and to provide at least the advantages described later.
In order to achieve these objects and other advantages in accordance with the present invention, there is provided a compound traditional Chinese medicine whitening skin cream, which is prepared from the following raw materials in parts by weight: 16-24 parts of pseudo-ginseng, 6-14 parts of caulis spatholobi, 7-13 parts of lonicera confusa, 7-13 parts of leech, 16-24 parts of lucid ganoderma, 16-24 parts of dried orange peel, 6-15 parts of pearl barley, 14-20 parts of wormwood, 8-13 parts of ginkgo kernel, 8-13 parts of angelica, 3-5 parts of pearl powder, 18-23 parts of mulberry oil, 3-5 parts of honey, 5-7 parts of lemon juice, 3-5 parts of carrot juice, 8-11 parts of glycerol and 50-80 parts of PEG.
Preferably, the compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 20 parts of pseudo-ginseng, 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 20 parts of lucid ganoderma, 20 parts of dried orange peel, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo seed, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
To achieve these objects and other advantages in accordance with the present invention, there is also provided a method for preparing a compound Chinese medicinal whitening skin cream, the method comprising the steps of:
(1) respectively taking pseudo-ginseng, caulis spatholobi, lonicera confusa, leech, lucid ganoderma, dried orange peel, pearl barley, wormwood, ginkgo seed and angelica sinensis, mashing, simultaneously putting into 75-85% ethanol, soaking for 100-130 minutes, and filtering to obtain filtrate A and filter residue;
(2) putting the filter residue obtained in the step (1) into 75-85% ethanol again, soaking for 100-130 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed liquor C in the step (3) at 75-85 ℃ under reduced pressure until the specific gravity of the mixed liquor C is 1-1.2 and the mixed liquor C is an alcohol smell-free extract;
(5) dissolving the extract in the step (4) in glycerol water, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot-melt state at the temperature of 60-80 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Preferably, the preparation method of the compound traditional Chinese medicine whitening and skin-care cream comprises the following steps:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, adding into 80% ethanol, soaking for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Preferably, in the preparation method of the compound traditional Chinese medicine whitening and skin-care cream, the PEG is a mixture of PEG400 and PEG4000 in a ratio of 1: 1.
Preferably, in the preparation method of the compound traditional Chinese medicine whitening and skin-care cream, the ratio of glycerin to water in the step (5) is 1: 5-1: 3.
Preferably, in the preparation method of the compound traditional Chinese medicine whitening and skin-care cream, ethanol volatilized in the process of decompressing and concentrating the mixed liquid C in the step (5) is collected, cooled, and used for extracting the medicinal components in the step (1) after being proportioned again.
PEG in the present invention refers to chemical polyethylene glycol.
The invention at least comprises the following beneficial effects: the synergistic effect of saponin in the pseudo-ginseng, polypeptide in the lucid ganoderma and synephrine in the dried orange peel can inhibit the generation of melanin, so that spots can disappear quickly, and the skin is ruddy, white and glossy; the skin cream has the components of pure traditional Chinese medicines and plant formulas, is safe and pollution-free, has lasting effect, and has no toxic or side effect after long-term use.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.
Example 1
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 16 parts of pseudo-ginseng, 6 parts of caulis spatholobi, 7 parts of lonicera confusa, 7 parts of leech, 16 parts of lucid ganoderma, 16 parts of dried orange peel, 6 parts of pearl barley, 14 parts of wormwood, 8 parts of ginkgo kernel, 8 parts of angelica, 3 parts of pearl powder, 18 parts of mulberry oil, 3 parts of honey, 5 parts of lemon juice, 3 parts of carrot juice, 8 parts of glycerol and 50 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, adding into 75% ethanol, soaking for 100 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 75% ethanol again, soaking for 100 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 75 ℃ under reduced pressure to obtain an alcohol-smell-free extract with the specific gravity of 1;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:5, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at the temperature of 60 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 2
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 24 parts of pseudo-ginseng, 14 parts of caulis spatholobi, 13 parts of lonicera confusa, 13 parts of leech, 24 parts of lucid ganoderma, 24 parts of dried orange peel, 15 parts of pearl barley, 20 parts of wormwood, 13 parts of ginkgo kernel, 13 parts of angelica, 5 parts of pearl powder, 23 parts of mulberry oil, 5 parts of honey, 7 parts of lemon juice, 5 parts of carrot juice, 11 parts of glycerol and 80 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, adding into 85% ethanol, soaking for 130 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 85% ethanol again, soaking for 130 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 85 ℃ under reduced pressure until the specific gravity is 1.2 and no alcohol smell exists;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:3, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at the temperature of 80 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 3
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 20 parts of pseudo-ginseng, 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 20 parts of lucid ganoderma, 20 parts of dried orange peel, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo seed, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, adding into 80% ethanol, soaking for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:4, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 4
The raw materials do not contain lucid ganoderma and tangerine peel.
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 20 parts of pseudo-ginseng, 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo kernel, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, soaking in 80% ethanol for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:4, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 5
The raw materials do not contain pseudo-ginseng and dried orange peel.
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 20 parts of lucid ganoderma, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo kernel, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, soaking in 80% ethanol for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:4, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 6
The raw materials do not contain pseudo-ginseng and lucid ganoderma.
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 20 parts of dried orange peel, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo kernel, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing caulis Spatholobi, flos Lonicerae, Hirudo, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, soaking in 80% ethanol for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:4, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 7
The raw materials do not contain dried orange peel.
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 20 parts of pseudo-ginseng, 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 20 parts of lucid ganoderma, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo seed, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, soaking in 80% ethanol for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:4, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 8
The raw materials do not contain lucid ganoderma.
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 20 parts of pseudo-ginseng, 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 20 parts of dried orange peel, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo seed, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, soaking in 80% ethanol for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:4, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
Example 9
The raw materials do not contain pseudo-ginseng.
A compound traditional Chinese medicine whitening skin cream is prepared from the following raw materials in parts by weight: 10 parts of caulis spatholobi, 10 parts of lonicera confusa, 10 parts of leech, 20 parts of lucid ganoderma, 20 parts of dried orange peel, 10 parts of pearl barley, 17 parts of wormwood, 10 parts of ginkgo seed, 10 parts of angelica, 4 parts of pearl powder, 20 parts of mulberry oil, 4 parts of honey, 6 parts of lemon juice, 4 parts of carrot juice, 10 parts of glycerol and 65 parts of PEG.
A preparation method of a compound traditional Chinese medicine whitening skin cream comprises the following steps:
(1) respectively mashing caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, soaking in 80% ethanol for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water with the ratio of 1:4, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
In one embodiment, in the preparation method of the compound traditional Chinese medicine whitening and skin-care cream, the PEG is a mixture of PEG400 and PEG4000 in a ratio of 1: 1.
In one embodiment, in the preparation method of the compound traditional Chinese medicine whitening and skin-care cream, the ratio of glycerol to water in the step (5) is 1: 5-1: 3.
In one embodiment, in the preparation method of the compound traditional Chinese medicine whitening and skin-care cream, ethanol volatilized in the process of decompressing and concentrating the mixed solution C in the step (5) is collected, cooled, and used for extracting the effective ingredients of the medicine in the step (1) after being proportioned again.
Examples of the experiments
Skin care effect test:
selecting 5 normal and healthy mice, unhairing and cleaning skin parts for experiments, detecting each experimental part of the mice 5 times by using an instrument, and taking an average value as a basic value; the skin cream is gently and uniformly smeared on the part to be tested of the mice for a specific time every day, after the skin cream is smeared for 30 days continuously, each experimental part of the mice is detected by an instrument for 5 times, and the average value is taken as an experimental value. Higher values of the measurements indicate less melanin content and a more shiny skin.
TABLE 1 test results (average value) of skin care effect of compound Chinese medicinal whitening and skin care cream
| Results of the melanin content test | Results of gloss measurement | |
| Non-smearing skin cream | 35 | 3.83 |
| Example 1 | 19 | 7.35 |
| Example 2 | 19 | 7.96 |
| Example 3 | 17 | 8.79 |
| Example 4 | 33 | 3.85 |
| Example 5 | 34 | 4.23 |
| Example 6 | 35 | 3.98 |
| Example 7 | 32 | 4.57 |
| Example 8 | 30 | 4.22 |
| Example 9 | 33 | 4.62 |
As shown in Table 1, pseudo-ginseng, lucid ganoderma and tangerine peel are added in the formula, and saponin in the pseudo-ginseng, polypeptide in the lucid ganoderma and synephrine in the tangerine peel have synergistic effect, so that melanin generation is inhibited, water-oil balance is promoted, the whitening and moisturizing effects of the compound traditional Chinese medicine whitening and skin-care cream are greatly improved, and no adverse reaction occurs in mice in and after experiments.
And (3) stability testing:
after standing for 6 months, the same test was carried out, and the skin-care and whitening effects of the skin-care creams of example 1, example 2 and example 3 were not changed, which could prove that the skin-care creams could be stably stored.
While embodiments of the invention have been disclosed above, it is not intended to be limited to the uses set forth in the specification and examples. It can be applied to all kinds of fields suitable for the present invention. Additional modifications will readily occur to those skilled in the art. Therefore, the invention is not to be limited to the specific details and embodiments shown and described herein, without departing from the general concept defined by the appended claims and their equivalents.
Claims (5)
1. The compound traditional Chinese medicine whitening skin cream is characterized by being prepared from the following raw materials in parts by weight: 16-24 parts of pseudo-ginseng, 6-14 parts of caulis spatholobi, 7-13 parts of lonicera confusa, 7-13 parts of leech, 16-24 parts of lucid ganoderma, 16-24 parts of dried orange peel, 6-15 parts of pearl barley, 14-20 parts of wormwood, 8-13 parts of ginkgo kernel, 8-13 parts of angelica, 3-5 parts of pearl powder, 18-23 parts of mulberry oil, 3-5 parts of honey, 5-7 parts of lemon juice, 3-5 parts of carrot juice, 8-11 parts of glycerol and 50-80 parts of PEG;
the preparation method of the skin cream comprises the following steps:
(1) respectively mashing pseudo-ginseng, caulis spatholobi, lonicera confusa, leech, lucid ganoderma, dried orange peel, pearl barley, wormwood, ginkgo seed and Chinese angelica, simultaneously putting into 75-85% ethanol, soaking for 100-130 minutes, and filtering to obtain filtrate A and filter residues;
(2) putting the filter residue obtained in the step (1) into 75-85% ethanol again, soaking for 100-130 minutes, and filtering to obtain a filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed liquid C in the step (3) at 75-85 ℃ under reduced pressure until the specific gravity is 1-1.2 and no alcohol smell exists in the extract;
(5) dissolving the extract in the step (4) in glycerol water, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot-melt state at the temperature of 60-80 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
2. The method of preparing a skin cream according to claim 1, comprising the steps of:
(1) respectively mashing Notoginseng radix, caulis Spatholobi, flos Lonicerae, Hirudo, Ganoderma, pericarpium Citri Tangerinae, Coicis semen, folium Artemisiae Argyi, semen Ginkgo, and radix Angelicae sinensis, adding into 80% ethanol, soaking for 120 min, and filtering to obtain filtrate A and residue;
(2) putting the filter residue obtained in the step (1) into 80% ethanol again, soaking for 120 minutes, and filtering to obtain filtrate B;
(3) mixing the filtrate A and the filtrate B, and stirring uniformly to obtain a mixed solution C;
(4) concentrating the mixed solution C in the step (3) at 80 ℃ under reduced pressure until the specific gravity is 1.05 and no alcohol smell is generated;
(5) dissolving the extract in the step (4) in glycerol water, adding pearl powder, mulberry oil, honey, lemon juice and carrot juice, and uniformly mixing to obtain a mixture;
(6) and (3) putting the mixture obtained in the step (5) into PEG in a hot melting state at 70 ℃, stirring, fully mixing, cooling to room temperature to obtain the compound traditional Chinese medicine whitening skin cream, and packaging.
3. The compound traditional Chinese medicine whitening and skin-care cream as claimed in claim 1, wherein the PEG is a mixture of PEG400 and PEG4000 in a ratio of 1: 1.
4. The preparation method of the skin cream according to claim 1, wherein the ratio of glycerin to water in the step (5) is 1:5 to 1: 3.
5. The method for preparing skin cream according to claim 1, wherein ethanol volatilized from the mixed solution C in the step (5) in the process of concentration under reduced pressure is collected, cooled, and used for extracting the medicinal components in the step (1) after being re-proportioned.
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