CN105997559A - Skin-beautifying and anti-pox composition and preparing method thereof - Google Patents
Skin-beautifying and anti-pox composition and preparing method thereof Download PDFInfo
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- CN105997559A CN105997559A CN201610310703.3A CN201610310703A CN105997559A CN 105997559 A CN105997559 A CN 105997559A CN 201610310703 A CN201610310703 A CN 201610310703A CN 105997559 A CN105997559 A CN 105997559A
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- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/26—Organic compounds, e.g. vitamins containing oxygen
- C11D9/265—Organic compounds, e.g. vitamins containing oxygen containing glycerol
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
Abstract
The invention discloses a skin-beautifying and anti-pox composition and a preparing method thereof. The composition comprises, by weight, 0.5-3 parts of hirudin extract, 0.2-2 parts of cordyceps sinensis extract, 0.1-1 part of American ginseng extract, 0.1-1 part of radix notoginseng extract and 0.05-0.5 part of angelica sinensis extract. By means of the composition, cells and hair follicles can be repaired, pores can be shrunk, the elasticity of skin can be improved, early generating of wrinkles can be prevented, freckles can be removed, skin-whitening and anti-pox effects can be achieved, acne and comedo can be removed, and skin becomes fine, smooth, ruddy and white.
Description
Technical field
The invention belongs to cosmetic technical field, be specifically related to a kind of skin Caring anti-acne compositions and preparation method thereof, said composition
There is the curative effect of freckle removing and whitening anti-acne.
Background technology
Hirudin (Hirudin) is that to have extracted activity in various active composition in Hirudo (Leech) and salivary gland thereof the most notable
And most studied a kind of composition, the small protein (polypeptide) that it is made up of 65 66 aminoacid.Hirudo
Containing abundant hirudin, hirudin has extremely strong inhibitory action to thrombin, is to be found the strongest thrombin up to now
Natural specific inhibitor.
Natural hirudin is the most most effective and safest natural thrombin inhibitor, with insulin, Herba Artemisiae Annuae
Element is collectively referred to as saving " world three element " of human diseases.Hirudin is of all times, the one energy that Chinese and western medicine theory is generally acknowledged
Effective Anti blood coagulation, antithrombus formation, and stop the blood further such as thrombin activation and platelet response of catalyzed by thrombin
Stasis of blood phenomenon.Fibroblastic breeding of its energy enzyme induction anticoagulant and the stimulation of thrombin Human Umbilical Vein Endothelial Cells.Its effect
Performance be by with thrombin in 1:1 ratio combine closely formation bring back to life thing, be that thrombin is more alive, have extremely strong anticoagulant
Effect;It is weak to Platelet, will not cause thrombocytopenia purpura, and its energy enzyme anticoagulant combines with platelet,
Promoting that thrombin and platelet are dissociated, suppression platelet, by the release of stimulated by thrombin and reacting of thrombin induction, has anti-blood
Platelet effect;It can eliminate angiemphraxis, makes hemocyte depolymerization, and thrombosis dissipates, and promotes that blood capillary is led to again, prevents apoplexy,
The corroded rock mass of human activin self, it is to avoid again produce thrombolytic etc., have stronger antithrombotic effect;It can make blood viscosity drop
Low, the erythrocyte electricity ice time shortens, and makes whole blood contrast viscosity, plasma viscosity, hematocrit and celloglobulin content fall
Low.
But there is presently no and hirudin is applied to cosmetic field.Inventor has a profound understanding of hirudin at treatment heart and brain blood
Huge medical value in pipe disease, continues to develop to the retrofit direction of Hirudo, through exploratory development for many years, repeatedly repaiies
Change, test, prove, the exploitation medicine adornment (special cosmetics) with freckle removing and whitening curative effect containing hirudin, and all warps
Cross the detection of " national cosmetic inspection center ", obtain the most qualified report.
Summary of the invention
It is an object of the invention to provide a kind of compositions with freckle removing and whitening anti-acne effect.
It is a still further object of the present invention to provide the preparation method of said composition.
It is an object of the invention to be accomplished by:
A kind of skin Caring anti-acne compositions, said composition includes following components:
The most above-mentioned skin Caring anti-acne compositions includes following components:
Above-mentioned said composition also comprises following components: the cell medium factor, YH-7,1,3 butylene glycol, silk peptide liquid, SY-45,
Clear speckle dispelling element-D, plants extraction whitening essence, plants extraction antiallergic essence, skin-balance element, Folium Ginkgo extract, and come into leaves car fare extract,
Ganoderma extract, Radix Rhodiolae extract, camomile extract, Margarita extract, glycerol, fatty alcohol, little daisy extract,
Ionized water.
Further preferably said composition comprises following components:
The present invention is with hirudin as main component, and the uniqueness comprising the rare Chinese medicines such as Cordyceps, Radix Panacis Quinquefolii, Radix Notoginseng, Radix Angelicae Sinensis is joined
Side, has speckle dispelling, skin moistening, the effect such as the whitest.
The Hirudo used is preferably wild narrow body scenery with hills and waters trematodiasis.In Radix Panacis Quinquefolii containing multiple ginsenoside, aminoacid, vitamin and
Mineral, can promote the blood circulation of subcutaneous capillary, increases the nutrition supply of skin, regulation of skin water balance, prolongs
Slow skin aging, has the melanic reducing property of suppression, makes skin pure white smooth.Be used in combination with hirudin also can antiinflammatory,
Detumescence, the facial pigmentation that disappears precipitation, reduce and suppress melanic growth, to acne, acne (being commonly called as " comedo "),
Black speck has the curative effect of uniqueness.Energy repair cell of the present invention and the function of hair follicle, pore refining, strengthen skin elasticity, prevent
Wrinkle is the most raw, has certain anti-aging effects, and skin becomes fine and smooth, ruddy, whitening naturally.
The preparation method of above-mentioned skin Caring anti-acne compositions comprises the following steps: by each component mix and blend under normal temperature condition be
?.
Skin Caring anti-acne compositions of the present invention can prepare speckle dispelling, whitening, anti-acne and the cosmetics of acne, acne of calming down
Middle application.Described cosmetics are emulsion, cleansing milk, facial soap, cosmetic water, facial cream.
The single chain polypeptide that natural hirudin is made up of 65 or 66 amino acid residues, molecular weight is about 7000, can be extremely
PH and heat condition under stable existence.Hirudin be shaped like Tinea Ranae, Tinea Ranae head is the end of polypeptide, rich in half Guang ammonia
Acid (cys), interacts to form 3 disulfide bond (Cys6-Cys14, Cys16-Cys28, Cys22-Cys39) between cysteine.
Make N-terminal close structure;Tinea Ranae afterbody is containing multiple acidic amino acids and a tyrosine being sulphated (Tyr63)
Peptide C end.Thrombin (thrombin) is the center enzyme in blood coagulation and hemostasis, and it not only can shear fibre
Fibrillarin is former, converts fibrinogen into fibrin;The enzyme of other solidificating blood can also be activated, such as thrombin
V, VIII, XIII and antithrombase PROTEIN C (Fenton, 1981) etc..The present invention will combine the famous and precious medium-height grass of multi-flavor in hirudin
Medicine, makes this product become a functional skin care item, these add Chinese herbal medicine constitute antiinflammatory, subside a swelling, disappear face
Pigementation, the brand-new secret of skin maintenance to acne (being commonly called as " comedo ") acne, black speck with unique curative effect is joined
System side, QI invigorating of stimulating the menstrual flow, invigorating middle warmer lung moistening, removing toxic substances nourishes blood, heat clearing away invigorating middle warmer, nutrition skin and promote the regeneration of cell, they
Not only increasing skin effect, moreover it is possible to set up the normal microcirculation of skin surface, subcutaneous fibrotic reparation strengthens reticuloendothelial system
Function, activate epithelial tissue, improve the microcirculation of skin subcutaneous capillary, reach speckle dispelling, anti-acne, beauty face-whitening-nourishing
Real effect.
Beneficial effects of the present invention compared with the prior art: the present composition can delay cell senescence, removes free radical, repaiies
Re-glue is former, immunomodulating, promotes skin micro ring.The most crease-resistant, whitening, antiinflammatory, the function subsiding a swelling, sterilize.No
Any toxic and side effects, it is adaptable to any age and any kind of skin.
Detailed description of the invention
By the following examples the present invention being further expalined explanation: wherein, Folium Ginkgo extract, the car fare that comes into leaves extract
Thing, Ganoderma extract, Radix Rhodiolae extract, camomile extract, Margarita extract, little daisy extract are purchased from lake
Zhou Zhenlu biological product company limited, the cell medium factor, YH-7,1,3 butylene glycol, silk peptide liquid, SY-45, clear speckle dispelling
Element-D, plant extraction whitening essence, plant extraction antiallergic essence, skin-balance element, glycerol, fatty alcohol and be purchased from Shanghai promise visitor's economy and trade limited
Company.
Embodiment 1
Formula:
Preparation method: by each component mix and blend under normal temperature condition, make emollient cream according to conventional skin moistening cream method.
Product quality meets national standard: frost class: QB/T1857-2013 (skin moistening cream).
The preparation method of hirudin extract: be ground to 80-100 mesh after Hirudo essence being examined, after using alkaline protease enzymology
50 DEG C of Water Under solutions obtain the hirudin extract that solid content is 4%.
Cordyceps extract: be ground to 80-100 mesh after being examined by Chinese caterpillar fungus extract, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Cordyceps extract that solid content is 4%.
Radix Panacis Quinquefolii extract: be ground to 80-100 mesh after Radix Panacis Quinquefolii essence being examined, uses 50 DEG C of conditions after alkaline protease enzymology
Lower hydrolysis obtains the Radix Panacis Quinquefolii extract that solid content is 4%.
Radix Notoginseng extract: be ground to 80-100 mesh after being examined by Radix Notoginseng essence, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Radix Notoginseng extract that solid content is 4%.
Radix Angelicae Sinensis extract: be ground to 80-100 mesh after being examined by tanquedate, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Radix Angelicae Sinensis extract that solid content is 4%.
Embodiment 2
Formula:
Preparation method: by each component mix and blend under normal temperature condition, add appropriate spice, enter back into vacuum homogenized milk
Change, make initial molecule structure fully emulsified, mixing, i.e. obtain emulsion after standing 24 hours.Product quality meets national standard:
Type of latex type: QB/T2286-1997.
The preparation method of hirudin extract: be ground to 80-100 mesh after Hirudo essence being examined, after using alkaline protease enzymology
50 DEG C of Water Under solutions obtain the hirudin extract that solid content is 4%.
Cordyceps extract: be ground to 80-100 mesh after being examined by Chinese caterpillar fungus extract, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Cordyceps extract that solid content is 4%.
Radix Panacis Quinquefolii extract: be ground to 80-100 mesh after Radix Panacis Quinquefolii essence being examined, uses 50 DEG C of conditions after alkaline protease enzymology
Lower hydrolysis obtains the Radix Panacis Quinquefolii extract that solid content is 4%.
Radix Notoginseng extract: be ground to 80-100 mesh after being examined by Radix Notoginseng essence, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Radix Notoginseng extract that solid content is 4%.
Radix Angelicae Sinensis extract: be ground to 80-100 mesh after being examined by tanquedate, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Radix Angelicae Sinensis extract that solid content is 4%.
Embodiment 3
Formula:
Preparation method: by each component mix and blend under normal temperature condition, add appropriate spice, washes one's face milk according to routine
Method makes cleansing milk.Product quality meets national standard: milk: QB/T1645-2004.
The preparation method of hirudin extract: be ground to 80-100 mesh after Hirudo essence being examined, after using alkaline protease enzymology
50 DEG C of Water Under solutions obtain the hirudin extract that solid content is 4%.
Cordyceps extract: be ground to 80-100 mesh after being examined by Chinese caterpillar fungus extract, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Cordyceps extract that solid content is 4%.
Radix Panacis Quinquefolii extract: be ground to 80-100 mesh after Radix Panacis Quinquefolii essence being examined, uses 50 DEG C of conditions after alkaline protease enzymology
Lower hydrolysis obtains the Radix Panacis Quinquefolii extract that solid content is 4%.
Radix Notoginseng extract: be ground to 80-100 mesh after being examined by Radix Notoginseng essence, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Radix Notoginseng extract that solid content is 4%.
Radix Angelicae Sinensis extract: be ground to 80-100 mesh after being examined by tanquedate, uses 50 DEG C of Water Unders after alkaline protease enzymology
Solution obtains the Radix Angelicae Sinensis extract that solid content is 4%.
Other testing performance index results (meet milk: QB/T1645-2004):
Fragrance meets regulation odor type;Texture uniformity;Color and luster meets regulation color and luster;It is heat-resisting: (39-41) DEG C keeps 24h,
Recover to room temperature without oil-water separation phenomenon;pH8.4;Centrifugation: 2000r/min, 30min are without oil-water separation;Antibacterial
Sum CFU/g < 10;Yeast and mold sum CFU/g < 10;Excrement colibacillus group does not detects;Bacillus pyocyaneus does not detects;
Staphylococcus aureus does not detects;Lead does not detects (detection limit 1.5ng/kg);Arsenic does not detects (detection limit 1.5ng/kg);
Hydrargyrum 0.01ng/kg.
The effect of the present composition is further illustrated below by way of clinical trial:
Inventor have chosen 68 people having small pox, speckle on the face, uses the product prepared according to embodiment method through one
The use in week, what speckle, variola shape alleviated has 51, and what wherein small pox was eliminated has 7, occupies efficiency 75% altogether, passes through
The use of 15 days, has 66 remarkable results, and worst effect is all that mottle shoals, and total effective rate reaches 98%.
Instantiation 1:
Old XX, female, 25 years old, cover with acne on the face because within 16 years old, rising, pachylosis, through multiple western medicines in treatment, several years one
Straight the best, the most worried, the rear beauty and skin care product using the embodiment of the present invention 2, the most effective, about ten days Cuo
Skin ulcer removes 30%, and first quarter moon substantially eliminates, and does not stay any trace to print.
Example 2:
Opening XX, female, 26 years old, originally facial skin was relatively rough, used the cleansing milk of the embodiment of the present invention 3 to wash one's face, and one
After week the most effective, exquisiteness, smooth that skin becomes.
Example 3:
Lee XX, man, 65 years old, originally face head had many senile plaques, once uses several QUBAN SHUANG, all without positive effect,
Using the beauty treatment and eliminating spot product of the embodiment of the present invention 2, after about 10 days, senile plaque just starts desalination.
Example 4:
Liu XX, man, 28 years old, because of work of going to work on a highway for a long time, is often exposed to the sun under the sun, therefore skin ratio
More black, use the embodiment of the present invention 1 beauty and skin care product, the most effective after one week, skin become fine and smooth, smooth and
Whitening.
The said goods is the most qualified by " national cosmetic quality inspection center " detection.And applied for State Administration for Industry & Commerce
Registered trade mark.
Claims (7)
1. a skin Caring anti-acne compositions, it is characterised in that said composition includes following components:
Skin Caring anti-acne compositions the most according to claim 1, it is characterised in that said composition includes following components:
Skin Caring anti-acne compositions the most according to claim 1, it is characterised in that said composition also comprises following components:
The cell medium factor, YH-7,1,3 butylene glycol, silk peptide liquid, SY-45, clear speckle dispelling element-D, plant extraction whitening essence, plant extraction
Antiallergic essence, skin-balance element, Folium Ginkgo extract, come into leaves car fare extract, Ganoderma extract, Radix Rhodiolae extract,
Camomile extract, Margarita extract, glycerol, fatty alcohol, little daisy extract, ionized water.
Skin Caring anti-acne compositions the most according to claim 3, it is characterised in that said composition the most specifically comprises following components:
5. the preparation method of the skin Caring anti-acne compositions described in a claim 1,2,3 or 4, it is characterised in that the method bag
Include following steps: by each component mix and blend and get final product under normal temperature condition.
6. the skin Caring anti-acne compositions described in claim 1,2,3 or 4 prepare speckle dispelling, whitening, anti-acne and calm down acne,
Application in the cosmetics of acne.
Application the most according to claim 6, it is characterised in that described cosmetics are emulsion, cleansing milk, facial soap, refreshing
Skin water, facial cream.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106591012A (en) * | 2016-11-25 | 2017-04-26 | 江苏爱西施科技服务咨询股份有限公司 | Silk peptide soap with skin tightening and spot removing functions and preparation method thereof |
CN109125239A (en) * | 2018-10-23 | 2019-01-04 | 缪剑华 | A kind of herbal mixture whitening skin-protection cream and preparation method |
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CN102178635A (en) * | 2011-04-27 | 2011-09-14 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106591012A (en) * | 2016-11-25 | 2017-04-26 | 江苏爱西施科技服务咨询股份有限公司 | Silk peptide soap with skin tightening and spot removing functions and preparation method thereof |
CN109125239A (en) * | 2018-10-23 | 2019-01-04 | 缪剑华 | A kind of herbal mixture whitening skin-protection cream and preparation method |
CN109125239B (en) * | 2018-10-23 | 2021-05-07 | 缪剑华 | Compound traditional Chinese medicine whitening skin cream and preparation method thereof |
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Application publication date: 20161012 |