CN105287292A - Whitening moisture-retention face cream and preparation method thereof - Google Patents
Whitening moisture-retention face cream and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The invention belongs to the technical field of cosmetics, and concretely relates to a whitening moisture-retention face cream and a preparation method thereof. The whitening moisture-retention face cream comprises the following components in parts by weight: 15-30 parts of a wetting agent, 2-5 parts of a thickening agent, 20-50 parts of a traditional Chinese medicine extract, 2-5 parts of additives, 1-5 parts of albolene and 40-60 parts of water, the traditional Chinese medicine extract is prepared from an eucommia extract, an aloe extract and a mixing extract according to a weight ratio being 6-12:3-6:9-18, and the preparation raw materials of the mixing extract product are composed of seeds of Job's tears, asparagus tuber and lucid ganoderma according to a weight ratio being 3-6:3-6:3-6. The whitening moisture-retention face cream has advantages of good permeability and easy absorption, is capable of whitening and keeping moisture effectively, improving dark skin, smoothing wrinkles, and keeping tender and smooth skin.
Description
Technical field
The present invention relates to cosmetic technical field, be specifically related to a kind of whitening skin and preserving moisture facial cream and preparation method thereof.
Background technology
People are subject to the impact of external environment, and the phenomenon such as drying, hydropenia easily appears in skin, and especially at spring, fall and winter, in the environment of dust storm, the easier dehydration of skin, peeling, general red, crackle etc. will appear in serious conditions, need to keep the skin wet in time.Hydropenia, long speckle, the colour of skin are dark yellow, and these are all the modal skin problems of women, how to improve the colour of skin, and making skin water tender, pale is that each women pursues.Whitening and moisturizing facial cream is in the market of a great variety, but mostly cures the symptoms, not the disease, and not can solve skin dark yellow, lacks water problem.
Chinese patent application 201410658243.4 discloses a kind of whitening and skin-protecting facial cream and preparation method thereof, and it comprises: polyethylene pyrrole network alkane ketone, Polyethylene Glycol, polyvinyl alcohol, carboxymethyl cellulose, essence, propylene glycol, methyl hydroxybenzoate, Chinese medical concrete, deionized water.But this skin protection facial cream is not remarkable in whitening skin and preserving moisture, and its poor permeability, be not easy to the absorption of skin.
In sum, in order to overcome the deficiencies in the prior art, providing more products to enrich the selection in market simultaneously, meeting the demand of people to high-quality cosmetics, be necessary to research and develop a kind of facial cream with significant whitening skin and preserving moisture effect.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of whitening skin and preserving moisture facial cream, its good penetrability, easily absorbs, and whitening skin and preserving moisture composition is effectively sent to skin deep layer, improves skin brightness, makes skin keep water tender glossy.
A kind of whitening skin and preserving moisture facial cream, be made up of the component of following parts by weight: wetting agent 15 ~ 30 parts, thickening agent 2 ~ 5 parts, Chinese medicine extract 20 ~ 50 parts, additive 2 ~ 5 parts, white vaseline 1 ~ 5 part and 40 ~ 60 parts, water, described Chinese medicine extract is made up of Cortex Eucommiae extract, Aloe extract and the mixed extract weight ratio according to 6 ~ 12:3 ~ 6:9 ~ 18, and the raw materials of described mixed extract is made up of Semen Coicis, Radix Asparagi and the Ganoderma weight ratio according to 3 ~ 6:3 ~ 6:3 ~ 6.
Preferably, described wetting agent is selected from least one in hyaluronic acid, glycerol and Natrulon H-10, and described thickening agent is selected from gelatin, and described additive comprises stearoxyl trimethyl silane, betanin, sodium cocoyl glycinate, EDETATE SODIUM and essence.
Preferably, described Cortex Eucommiae extract is obtained by following steps:
S1: take the Cortex Eucommiae by 6 ~ 12 parts by weight, pulverizes mixing after cleaning, drying, and add the water soaking 35 ~ 60 minutes of medical material gross weight 6 ~ 10 times amount, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, filters and retain filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 6 ~ 10 times amount volume fraction in filtering residue is the ethanol of 60 ~ 85%, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 ~ 24 hours, centrifugal 15 ~ 20 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 36 ~ 45 DEG C, and material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.2 ~ 0.3MPa, when feed liquid stock solution reduces 1/10 ~ 1/4, then the ultrafiltration 1 ~ 3 time that adds water, merge ultrafiltrate, obtain Cortex Eucommiae extract.
Preferably, described Aloe extract is obtained by following steps:
S1: get Aloe 3 ~ 6 parts, cleans, and after drying, is squeezed obtain Aloe mixing juice with squeezer;
S2: the Aloe obtained mixing juice is put in filtering tank, removes impurity, obtain Aloe original juice;
S3: put in vacuum-concentrcted device by Aloe original juice liquid and concentrate, concentrated 2 ~ 3 times of circulation, obtains Aloe extract.
Preferably, described mixed extract is obtained by following steps:
Get Semen Coicis 3 ~ 6 parts, Radix Asparagi 3 ~ 6 parts and Ganoderma 3 ~ 6 parts, coarse powder is ground into after mixing, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding 15 ~ 25 parts by weight is the alcoholic solution of 75 ~ 85%, regulation and control carbon dioxide flow is 12 ~ 15L/h, and extracting pressure is 12 ~ 15MPa, and extraction temperature is 40 ~ 60 DEG C, extraction time is 3 ~ 7 hours, and decompression separation obtains described mixed extract.
Preferably, described whitening skin and preserving moisture facial cream is made up of the component of following parts by weight: hyaluronic acid 3 ~ 9 parts, 2 ~ 5 parts, gelatin, stearoxyl trimethyl silane 2 ~ 5 parts, glycerol 2 ~ 5 parts, Natrulon H-10 1 ~ 5 part, sodium cocoyl glycinate 0.2 ~ 1 part, betanin 0.2 ~ 1 part, Cortex Eucommiae extract 6 ~ 12 parts, Aloe extract 3 ~ 6 parts, mixed extract 9 ~ 18 parts, EDETATE SODIUM 0 ~ 0.5 part, 0.01 ~ 0.2 part, essence, white vaseline 1 ~ 5 part and 40 ~ 60 parts, water.
Preferably, described whitening skin and preserving moisture facial cream is made up of the component of following parts by weight: hyaluronic acid 6 parts, 3 parts, gelatin, stearoxyl trimethyl silane 3 parts, glycerol 3 parts, Natrulon H-10 2 parts, sodium cocoyl glycinate 0.5 part, betanin 0.5 part, Cortex Eucommiae extract 8 parts, Aloe extract 4 parts, mixed extract 15 parts, EDETATE SODIUM 0.5 part, 0.2 part, essence, white vaseline 3 parts and 50 parts, water.
Containing sodium cocoyl glycinate and betanin two seed amino acid class surfactant in whitening skin and preserving moisture facial cream of the present invention, the two character is gentle, soft to skin, do not cause allergy, also have excellent wettability, water solublity, anti-water hardness tolerance and antibiotic property, its faintly acid same with skin makes skin feel comfortable, soft and moist simultaneously, all low stimulation of both what is more important, low toxicity, there is good biodegradability properties, and the two is worked in coordination with, and reaches antiallergic, safe and non-stimulating effect.
Cortex Eucommiae extract of the present invention is rich in the unsaturated fatty acid such as linolenic acid, linoleic acid, wherein α ~ linolenic content is more up to 61%, α ~ linolenic acid belongs to Omega ~ 3 class fatty acid, it is the base structure of composition cell membrane, the nutritive equilibrium of cell membrane can be safeguarded, resist the infringement of external environment to skin, make skin present efficient regeneration, moisturizing, the daily life function such as penetrating; The natural preventive of skin can also be protected and strengthen to Omega ~ 3 fatty acid, increases cell membrane elasticity and activating cell, improve the quality of epidermal area, and reduce the deposition of pigment, skin care, improves coarse, the obscure skin without light quality; In addition, eucommia ulmoides seed oil is also containing the functional component such as aucubin, chlorogenic acid, and enhance metabolism, it has good non-oxidizability and the ability of scavenging activated oxygen.
The raw materials of described mixed extract has Semen Coicis, Radix Asparagi and Ganoderma, wherein containing rich in protein and vitamin in Semen Coicis, skin can be made delicate fine and smooth, eliminating mottle with reducing wrinkle, eliminate pigment, have obvious curative effect to face acne and pachylosis; The aspartic acid contained in Radix Asparagi has non-oxidizability, can stop the oxidation of unsaturated fatty acid, delays and treat the keratinization of skin, keeps the soft and smooth and moistening of skin, makes skin water tender flexible; Ganoderma contains the composition of check melanin and the multiple trace element etc. to skin beneficiating, these compositions can by reducing human free radical, accelerate the regeneration of cell, increase the thickness of skin and increase collagen, reach plump skin, eliminate the effect of microgroove and wrinkle; Polysaccharide component wherein by keeping and regulation of skin aqueous, can recover skin elasticity, making skin wet, exquisiteness.
Barbaloin energy regulation of skin contained by described Aloe extract, has the effect of obvious skin care and Palmitoleic Acid, can promote skin metabolism, be conducive to living again of outer skin tissue, have Promotive union effect to wound.
Described white vaseline has superpower moisture-keeping function, its no color or smell, has extraordinary penetration, can penetrate into skin bottom fast, make skin full glossy, reach further and reduce skin microgroove, antidotal effect after contact skin.
Whitening skin and preserving moisture facial cream of the present invention has extraordinary penetration, can penetrate into skin bottom fast, and can excite the generation of the collagen protein of deep skin after contact skin, the supporting construction of regeneration and reparation skin.Whitening skin and preserving moisture facial cream of the present invention contains Cortex Eucommiae extract, Aloe extract, Semen Coicis extract, Radix Asparagi extract, the multiple natural plant composition such as Ganoderma extract, again in conjunction with white vaseline and hyaluronic acid, gelatin, stearoxyl trimethyl silane, glycerol, polyglycereol ~ 10, sodium cocoyl glycinate, betanin, EDETATE SODIUM, the basic materials such as essence, each component is worked in coordination with, make whitening skin and preserving moisture facial cream good penetrability of the present invention, easy absorption, deep moisturizing whitening, nourish maintenance skin, strengthen skin elastic and to improve skin obscure, dry, relaxation, repair impaired or innutritive cell, whitening skin and preserving moisture composition is effectively sent to skin deep layer simultaneously, repair wrinkle of skin, suppress wrinkle regeneration, delay skin aging.
Present invention also offers the preparation method of above-mentioned whitening skin and preserving moisture facial cream, specifically comprise the following steps:
S1: thickening agent, white vaseline are placed in oil phase pot, are heated to 75 ~ 90 DEG C, obtain material A after stirring and dissolving is complete, the mixing speed of stirring is 40 ~ 50r/min, and insulation is for subsequent use;
S2: wetting agent, water are heated to 85 ~ 90 DEG C and dissolve completely, in the emulsifying pot of then suction preheating, opens and stirs, the mixing speed stirred is 40 ~ 50r/min, again by slow for material A suction emulsifying pot, lower the temperature after homogenizing 10 ~ 15min, the rotating speed of homogenizing is 2000 ~ 3000rpm;
S3: be down to 60 DEG C, add additive, homogenizing 3 ~ 8min;
S4: continue to be cooled to 40 DEG C, add Chinese medicine extract and be stirred to evenly, sampling Detection, namely qualified rear discharging obtains whitening skin and preserving moisture facial cream.
Preferably, described Chinese medicine extract is obtained by following steps:
S1: take the Cortex Eucommiae by 6 ~ 12 parts by weight, pulverizes mixing after cleaning, drying, and add the water soaking 35 ~ 60 minutes of medical material gross weight 6 ~ 10 times amount, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, filters and retain filtering residue, merging filtrate, obtaining Aqueous extracts; In filtering residue, add medical material gross weight 6 ~ 10 times amount volume fraction is the ethanol of 60 ~ 85%, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, and filter, merging filtrate, obtains alcohol extract; Merge Aqueous extracts and alcohol extract, after stirring, leave standstill 12 ~ 24 hours, centrifugal 15 ~ 20 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 36 ~ 45 DEG C, and material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.2 ~ 0.3MPa, when feed liquid stock solution reduces 1/10 ~ 1/4, then the ultrafiltration 1 ~ 3 time that adds water, merge ultrafiltrate, obtain Cortex Eucommiae extract;
S2: take Semen Coicis 3 ~ 6 parts, Radix Asparagi 3 ~ 6 parts and Ganoderma 3 ~ 6 parts, coarse powder is ground into after mixing, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding 15 ~ 25 parts by weight is the alcoholic solution of 75 ~ 85%, regulation and control carbon dioxide flow is 12 ~ 15L/h, and extracting pressure is 12 ~ 15MPa, and extraction temperature is 40 ~ 60 DEG C, extraction time is 3 ~ 7 hours, and decompression separation obtains described mixed extract;
S3: get Aloe 3 ~ 6 parts, cleans, and after drying, is squeezed obtain Aloe mixing juice with squeezer; The Aloe obtained mixing juice is put in filtering tank, removes impurity, obtain Aloe original juice; Put in vacuum-concentrcted device by Aloe original juice liquid and concentrate, concentrated 2 ~ 3 times of circulation, obtains Aloe extract;
S4: Cortex Eucommiae extract, mixed extract and Aloe extract are merged and obtains described Chinese medicine extract.
Therefore, compared with prior art, advantage of the present invention is:
(1) whitening skin and preserving moisture facial cream of the present invention contains the multiple natural plant active components such as Cortex Eucommiae extract, Aloe extract, Semen Coicis extract, Radix Asparagi extract, Ganoderma extract, deep moisturizing whitening, nourish maintenance skin, improve dull-looking skin, drying, relaxation, whitening skin and preserving moisture composition is effectively sent to skin deep layer simultaneously, repair impaired or innutritive cell, effectively calm down microgroove, slowing down skin aging, makes skin beauty water tender smooth, high resilience, promotes skin brightness.
(2) whitening skin and preserving moisture facial cream safety and stability of the present invention, good penetrability, easily absorbs, and uses rear skin salubrious not sticky; And the preparation method of whitening skin and preserving moisture facial cream of the present invention is simple, condition is controlled, process stabilizing, can be applicable.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, whitening skin and preserving moisture facial cream of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
The raw material (with weight parts) of the embodiment of the present invention 1 ~ 3 and comparative example 1,2 facial cream is as follows:
Meet the pertinent regulations requirement of QB/T1857 ~ 2013 through inspection embodiment 1 ~ 3 product, sense index (color and luster, fragrance, structure) meets industry regulation, and physical and chemical index (PH, heat-resisting, cold-resistant, active matter) meets industry regulation.
embodiment 4: the preparation method of the embodiment of the present invention 1 whitening skin and preserving moisture facial cream
S1: get the Cortex Eucommiae 6 parts, pulverizes mixing after cleaning, drying, and add the water soaking 35 minutes of medical material gross weight 6 times amount, reflux, extract, 1 time, each 4 hours, filters and retain filtering residue, merging filtrate, obtaining Aqueous extracts; In filtering residue, add medical material gross weight 6 times amount volume fraction is the ethanol of 75%, reflux, extract, 1 time, each 4 hours, and filter, merging filtrate, obtains alcohol extract; Merge Aqueous extracts and alcohol extract, after stirring, leave standstill 12 hours, centrifugal 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 36 DEG C, and material liquid pH is 6, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.2MPa, when feed liquid stock solution reduces 1/10, then the ultrafiltration 1 time that adds water, merge ultrafiltrate, obtain Cortex Eucommiae extract;
S2: get Semen Coicis 3 parts, Radix Asparagi 3 parts and Ganoderma 3 parts, coarse powder is ground into after mixing, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding 15 parts by weight is the alcoholic solution of 75%, regulation and control carbon dioxide flow is 12L/h, and extracting pressure is 12MPa, and extraction temperature is 45 DEG C, extraction time is 3 hours, and decompression separation obtains described mixed extract;
S3: get Aloe 3 parts, cleans, and after drying, is squeezed obtain Aloe mixing juice with squeezer; The Aloe obtained mixing juice is put in filtering tank, removes impurity, obtain Aloe original juice; Put in vacuum-concentrcted device by Aloe original juice liquid and concentrate, concentrated 2 times of circulation, obtains Aloe extract;
S4: Cortex Eucommiae extract, mixed extract and Aloe extract are merged and obtains described Chinese medicine extract;
S5: get 2 parts, gelatin, white vaseline 2 parts is placed in oil phase pot, be heated to 75 DEG C, obtain material A after stirring and dissolving is complete, the mixing speed of stirring is 40r/min, and insulation is for subsequent use;
S6: hyaluronic acid 3 parts, glycerol 2 parts, polyglycereol ~ 101 part are heated to 85 ~ 90 DEG C with 40 parts, water and dissolve completely, in the emulsifying pot of then suction preheating, open and stir, the mixing speed stirred is 40r/min, again by slow for material A suction emulsifying pot, lower the temperature after homogenizing 10min, the rotating speed of homogenizing is 2000rpm;
S7: be down to 60 DEG C, adds stearoxyl trimethyl silane 2 parts, sodium cocoyl glycinate 0.2 part, betanin 0.2 part, EDETATE SODIUM 0.2 part and 0.1 part, essence, homogenizing 3min;
S8: continue to be cooled to 40 DEG C, add above-mentioned Chinese medicine extract and be stirred to evenly, sampling Detection, namely qualified rear discharging obtains whitening skin and preserving moisture facial cream.
embodiment 5:the preparation method of the embodiment of the present invention 2 whitening skin and preserving moisture facial cream
S1: get the Cortex Eucommiae 12 parts, pulverizes mixing after cleaning, drying, and add the water soaking 60 minutes of medical material gross weight 10 times amount, reflux, extract, 2 times, each 6 hours, filters and retain filtering residue, merging filtrate, obtaining Aqueous extracts; In filtering residue, add medical material gross weight 10 times amount volume fraction is the ethanol of 85%, reflux, extract, 2 times, each 6 hours, and filter, merging filtrate, obtains alcohol extract; Merge Aqueous extracts and alcohol extract, after stirring, leave standstill 24 hours, centrifugal 20 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 36 DEG C, and material liquid pH is 6, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.3MPa, when feed liquid stock solution reduces 1/4, then the ultrafiltration 3 times that adds water, merge ultrafiltrate, obtain Cortex Eucommiae extract;
S2: get Semen Coicis 6 parts, Radix Asparagi 6 parts and Ganoderma 6 parts, coarse powder is ground into after mixing, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding 25 parts by weight is the alcoholic solution of 85%, regulation and control carbon dioxide flow is 15L/h, and extracting pressure is 15MPa, and extraction temperature is 60 DEG C, extraction time is 7 hours, and decompression separation obtains described mixed extract;
S3: get Aloe 6 parts, cleans, and after drying, is squeezed obtain Aloe mixing juice with squeezer; The Aloe obtained mixing juice is put in filtering tank, removes impurity, obtain Aloe original juice; Put in vacuum-concentrcted device by Aloe original juice liquid and concentrate, concentrated 3 times of circulation, obtains Aloe extract;
S4: Cortex Eucommiae extract, mixed extract and Aloe extract are merged and obtains described Chinese medicine extract;
S5: get 5 parts, gelatin, white vaseline 5 parts is placed in oil phase pot, be heated to 75 DEG C, obtain material A after stirring and dissolving is complete, the mixing speed of stirring is 50r/min, and insulation is for subsequent use;
S6: hyaluronic acid 9 parts, glycerol 5 parts, polyglycereol ~ 105 part are heated to 85 ~ 90 DEG C with 60 parts, water and dissolve completely, in the emulsifying pot of then suction preheating, open and stir, the mixing speed stirred is 50r/min, again by slow for material A suction emulsifying pot, lower the temperature after homogenizing 15min, the rotating speed of homogenizing is 3000rpm;
S7: be down to 60 DEG C, adds stearoxyl trimethyl silane 5 parts, sodium cocoyl glycinate 1 part, betanin 1 part, EDETATE SODIUM 0.5 part and 0.2 part, essence, homogenizing 8min;
S8: continue to be cooled to 40 DEG C, add above-mentioned Chinese medicine extract and be stirred to evenly, sampling Detection, namely qualified rear discharging obtains whitening skin and preserving moisture facial cream.
embodiment 6:the preparation method of the embodiment of the present invention 3 whitening skin and preserving moisture facial cream
S1: get the Cortex Eucommiae 8 parts, pulverizes mixing after cleaning, drying, and add the water soaking 45 minutes of medical material gross weight 8 times amount, reflux, extract, 2 times, each 5 hours, filters and retain filtering residue, merging filtrate, obtaining Aqueous extracts; In filtering residue, add medical material gross weight 8 times amount volume fraction is the ethanol of 80%, reflux, extract, 2 times, each 5 hours, and filter, merging filtrate, obtains alcohol extract; Merge Aqueous extracts and alcohol extract, after stirring, leave standstill 12 hours, centrifugal 15 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 40 DEG C, and material liquid pH is 7, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.25MPa, when feed liquid stock solution reduces 1/6, then the ultrafiltration 2 times that adds water, merge ultrafiltrate, obtain Cortex Eucommiae extract;
S2: get Semen Coicis 4 parts, Radix Asparagi 4 parts and Ganoderma 4 parts, coarse powder is ground into after mixing, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding 20 parts by weight is the alcoholic solution of 80%, regulation and control carbon dioxide flow is 13L/h, and extracting pressure is 13MPa, and extraction temperature is 50 DEG C, extraction time is 5 hours, and decompression separation obtains described mixed extract;
S3: get Aloe 4 parts, cleans, and after drying, is squeezed obtain Aloe mixing juice with squeezer; The Aloe obtained mixing juice is put in filtering tank, removes impurity, obtain Aloe original juice; Put in vacuum-concentrcted device by Aloe original juice liquid and concentrate, concentrated 2 times of circulation, obtains Aloe extract;
S4: Cortex Eucommiae extract, mixed extract and Aloe extract are merged and obtains described Chinese medicine extract;
S5: get 3 parts, gelatin, white vaseline 3 parts is placed in oil phase pot, be heated to 85 DEG C, obtain material A after stirring and dissolving is complete, the mixing speed of stirring is 45r/min, and insulation is for subsequent use;
S6: hyaluronic acid 6 parts, glycerol 3 parts, polyglycereol ~ 102 part are heated to 85 ~ 90 DEG C with 50 parts, water and dissolve completely, in the emulsifying pot of then suction preheating, open and stir, the mixing speed stirred is 45r/min, again by slow for material A suction emulsifying pot, lower the temperature after homogenizing 12min, the rotating speed of homogenizing is 2500rpm;
S7: be down to 60 DEG C, adds stearoxyl trimethyl silane 3 parts, sodium cocoyl glycinate 0.5 part, betanin 0.5 part, EDETATE SODIUM 0.5 part and 0.2 part, essence, homogenizing 5min;
S8: continue to be cooled to 40 DEG C, add above-mentioned Chinese medicine extract and be stirred to evenly, sampling Detection, namely qualified rear discharging obtains whitening skin and preserving moisture facial cream.
The preparation method reference example 3 of comparative example 1,2.
test example one, Product Safety evaluation (experiment of human body skin patch)
One, trial target: the whitening skin and preserving moisture facial cream that embodiment 1 ~ 3, comparative example 1 ~ 2 prepare.
Tested crowd's number: 100 people, women.
Age: between 25 ~ 55 years old.
Health status: subjects skin is healthy, without dermatosis allergies, meets experimenter and volunteers inclusion criteria.
Grouping: 5 groups, often organize 20 people, 27 ± 2 years old mean age.
Two, patch method: select qualified speckle examination device, with closed patch experiment method, tested material being about 0.025g ~ 0.03g drips in speckle examination device, external special adhesive tape is covered on experimenter back, tested material is removed after 24 hours, within after removing respectively 0.5,6,12,24,48 hour, observe dermoreaction, according to its result of dermoreaction grade scale record in " cosmetics health specification ".
Three, experimental result: human skin patch result shows: each group experimenter is by the patch test of the whitening skin and preserving moisture facial cream of embodiment 1 ~ 3, comparative example 1,2, dermoreaction is observed at 0.5,6,12,24,48 hour, wherein there is skin adverse reaction in 0 example, the whitening skin and preserving moisture facial cream use safety described in explanation.
test example two, product effect assessment
part I:.
One, trial target: the whitening skin and preserving moisture facial cream that embodiment 1 prepares
Two, tested crowd
Sex number: female, 50 people.
Age: between 30 ~ 55 years old.
Health status: subjects skin is healthy, without dermatosis allergies, meets experimenter and volunteers inclusion criteria.
Three, method of testing: adopt the skin elasticity CotometerMPA580 main frame that German Courage+Khazaka company (German CK company) manufactures, the probe used is ReviscometerRV600 elastic fibrous tissue test probe, surveys and averages for five times.Test zone: place between the eyebrows middle is 3cm forehead region, lower lip middle down 3cm chin area, the left and right cheek region of nose and pupil intersection place up.First measure the blank value (R2, R5, R7) of 30min after tested region clean, then specify that experimenter adheres to using above-mentioned trial target every day sooner or later, test test zone skin elasticity index R2, R5, R7 value (in test process, negative pressure is constant is 450mbar) after 1 week, 2 weeks, 3 weeks, 4 weeks respectively.
Index illustrates: skin elasticity index R2, R5, R7 are more close to 1, and the elasticity of skin is better.
R2=Ua/Uf；R5=Ur/Ue；R7=Ur/Uf
Uf---skin maximum tension amount
Ue---constant negative pressure is added to after on skin, the amount of tension of skin during 0.1 second, positioning elastic part amount of tension.
Ur---cancel after negative pressure, skin will restore to the original state rapidly state, is divided into elastic score value Ur equally, namely cancels negative pressure after 0.1 second, the recovery value of skin and visco-elastic portions value, or claim plastic value.
Ua---from cancelling the recovery value of negative pressure to skin when follow-on test skin surface adds negative pressure more next time.
Four, test result is as following table 1.
Table 1 embodiment 1 whitening skin and preserving moisture facial cream table with test results
From upper table 1: use whitening skin and preserving moisture facial cream first week rear R2, R5, R7 of embodiment 1 to increase to some extent, within 4th week, R2, R5, R7 all rise obviously, and R2, R5, R7 value levels off to 1, the skin elasticity index of experimenter has very large lifting, as can be seen here, this whitening skin and preserving moisture facial cream has increases skin elasticity, antidotal effect.
part II:
One, trial target: embodiment 1 ~ 3, whitening skin and preserving moisture facial cream prepared by comparative example 1,2.
Two, tested crowd
Sex number: female, 200 people.
Age: between 25 ~ 55 years old.
Health status: subjects skin is healthy, without dermatosis allergies, meets experimenter and volunteers inclusion criteria.
Grouping: be divided into 5 groups, often organize 40 people, 28 ± 2 years old mean age.
Three, method of testing: respectively use-case 1 ~ 3, whitening skin and preserving moisture facial cream prepared by comparative example 1,2, observes and experiences result of use.Using method: after experimenter cleans face, appropriate facial cream is in the palm of the hand, even point is applied to face skin, massage is until absorb completely gently, the every day of each use sooner or later once, adhere to use one month, at least check weekly once to understand with or without whole body and local untoward reaction, and itemized record result.
Four, testing evaluation result is as follows:
(one month) on probation feedback conclusive table of table 2 embodiment 1 whitening skin and preserving moisture facial cream
(one month) on probation feedback conclusive table of table 3 embodiment 2 whitening skin and preserving moisture facial cream
(one month) on probation feedback conclusive table of table 4 embodiment 3 whitening skin and preserving moisture facial cream
(one month) on probation feedback conclusive table of table 5 comparative example 1 whitening skin and preserving moisture facial cream
(one month) on probation feedback conclusive table of table 6 comparative example 2 whitening skin and preserving moisture facial cream
(1) from upper table 2 ~ 4, whitening skin and preserving moisture facial cream the liking and approving extensively by experimenter of the embodiment of the present invention 1 ~ 3, experimenter all represents whitening skin and preserving moisture facial cream good penetrability of the present invention, easy absorption, use rear skin around the eyes salubrious not sticky, to skin supply nutrition, promote skin metabolism, whitening skin and preserving moisture composition is effectively sent to skin deep layer, it is effective that to improve skin obscure, improve skin brightness, slowing down skin aging, and effectively improve drying, relaxation, skin beauty water is moistened smooth, high resilience, wherein the highest with the degree of recognition of embodiment 1 whitening skin and preserving moisture facial cream, therefore embodiment 1 is most preferred embodiment.
(2) from upper table 5 ~ 6, comparative example 1 and comparative example 2 whitening skin and preserving moisture facial cream all lack some component in whitening skin and preserving moisture facial cream formula of the present invention, its result of use, all not as embodiment 1 ~ 3, illustrates that whitening skin and preserving moisture facial cream formula of the present invention is not obtained by the simple combination of each component.
There is not people to occur allergic phenomena in whole experimenter simultaneously, all do not occur the situations such as skin pruritus, twinge, redness yet.Therefore, the gentle safety of whitening skin and preserving moisture facial cream of the present invention, can life-time service.
part III: the whitening effect of whitening skin and preserving moisture facial cream of the present invention
One, trial target: the whitening skin and preserving moisture facial cream that embodiment 1,2,3 prepares.
Two, test philosophy and standard: whitening skin and preserving moisture facial cream of the present invention is active by restraint of tyrosinase or blocks and generate melanic oxidation reaction from tyrosine, reduce melanic generation thus reach the effect of skin whitening, detect its whitening effect by measuring the suppression ratio of whitening skin and preserving moisture cleansing cream of the present invention to tryrosinase, the higher whitening effect of suppression ratio is better.
Three, method of testing:
Matched group: commercial whitening agent arbutin;
Test group 1: the whitening skin and preserving moisture facial cream that the embodiment of the present invention 1 is obtained;
Test group 2: the whitening skin and preserving moisture facial cream that the embodiment of the present invention 2 is obtained;
Test group 3: the whitening skin and preserving moisture facial cream that the embodiment of the present invention 3 is obtained.
1) preparation of matched group solution to be measured: get commercial whitening agent arbutin 1g in 10ml beaker, add a small amount of distilled water, be stirred to arbutin and fully dissolve, continues to add distilled water to 5ml.
2) preparation of test group solution to be measured: get the present embodiment 1,2,3 whitening skin and preserving moisture facial cream 1g respectively in 3 10ml beakers, respectively add a small amount of distilled water, be stirred to facial cream and fully dissolve, continues to add distilled water to 5ml.
3) preparation of base soln: the 0.2mol/lPBS(phosphate buffer preparing 100u/ml tyrosinase solution, 2.0mmol/lL ~ tyrosine solution and pH=6.8 respectively) solution based on solution.
4) get 4 test tube accordings to the form below and quantitatively add each base soln and test group solution to be measured, shake up;
5) 1,2,3, No. 4 test tube is placed in the heating of 310K water-bath after 60 minutes, adopts visible spectrophotometric instrument to measure its absorbance under wavelength 475nm respectively, according to following computing formula:
Tyrosinase inhibition rate (%)=[1-(A3-A4)/(A1-A2)] × 100%
Calculate the solution to be measured of this concentration to the suppression ratio of tryrosinase;
6) step 4) and 5 is repeated), measure matched group solution to be measured to the suppression ratio of tryrosinase.
Four, test result is as table 7
Table 7 whitening skin and preserving moisture facial cream whitening effect table with test results
L ~ tyrosine (analytical pure), purchased from Solarbio company; Tryrosinase (analytical pure), available from Sigma; Sodium hydrogen phosphate (analytical pure), purchased from Chemical Reagent Co., Ltd., Sinopharm Group; Sodium dihydrogen phosphate (analytical pure), purchased from Chemical Reagent Co., Ltd., Sinopharm Group.
As seen from the above table: the embodiment of the present invention 1,2,3 is under visible spectrophotometric instrument wavelength 475nm, record absorbance as calculated the suppression ratio of whitening skin and preserving moisture facial cream to tryrosinase of the embodiment of the present invention 1,2,3 is respectively 73.2%, 69.3%, 68.5%, wherein best with the whitening effect of embodiment 1 whitening skin and preserving moisture facial cream, and the suppression ratio of commercial arbutin to tryrosinase is only 63.6%, visible whitening skin and preserving moisture facial cream of the present invention has more significant whitening effect compared with commercial arbutin.
Above-described embodiment is illustrative principle of the present invention and effect thereof only, but not for limiting the present invention.Any person skilled in the art scholar all without prejudice under spirit of the present invention and category, can modify above-described embodiment or changes.Therefore, such as have in art usually know the knowledgeable do not depart from complete under disclosed spirit and technological thought all equivalence modify or change, must be contained by claim of the present invention.
Claims (9)
1. a whitening skin and preserving moisture facial cream, it is characterized in that, be made up of the component of following parts by weight: wetting agent 15 ~ 30 parts, thickening agent 2 ~ 5 parts, Chinese medicine extract 20 ~ 50 parts, additive 2 ~ 5 parts, white vaseline 1 ~ 5 part and 40 ~ 60 parts, water, described Chinese medicine extract is made up of Cortex Eucommiae extract, Aloe extract and the mixed extract weight ratio according to 6 ~ 12:3 ~ 6:9 ~ 18, and the raw materials of described mixed extract is made up of Semen Coicis, Radix Asparagi and the Ganoderma weight ratio according to 3 ~ 6:3 ~ 6:3 ~ 6.
2. whitening skin and preserving moisture facial cream as claimed in claim 1, it is characterized in that, described wetting agent is selected from least one in hyaluronic acid, glycerol and Natrulon H-10, described thickening agent is selected from gelatin, and described additive comprises stearoxyl trimethyl silane, betanin, sodium cocoyl glycinate, EDETATE SODIUM and essence.
3. whitening skin and preserving moisture facial cream as claimed in claim 1, it is characterized in that, described Cortex Eucommiae extract is obtained by following steps:
S1: take the Cortex Eucommiae by 6 ~ 12 parts by weight, pulverizes mixing after cleaning, drying, and add the water soaking 35 ~ 60 minutes of medical material gross weight 6 ~ 10 times amount, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, filters and retain filtering residue, merging filtrate, obtaining Aqueous extracts;
S2: adding medical material gross weight 6 ~ 10 times amount volume fraction in filtering residue is the ethanol of 60 ~ 85%, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, filter, merging filtrate, obtains alcohol extract;
S3: merge Aqueous extracts and alcohol extract, after stirring, leaves standstill 12 ~ 24 hours, centrifugal 15 ~ 20 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 36 ~ 45 DEG C, and material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.2 ~ 0.3MPa, when feed liquid stock solution reduces 1/10 ~ 1/4, then the ultrafiltration 1 ~ 3 time that adds water, merge ultrafiltrate, obtain Cortex Eucommiae extract.
4. whitening skin and preserving moisture facial cream as claimed in claim 1, it is characterized in that, described Aloe extract is obtained by following steps:
S1: take Aloe by the parts by weight of 3 ~ 6, cleans, and after drying, is squeezed obtain Aloe mixing juice with squeezer;
S2: the Aloe obtained mixing juice is put in filtering tank, removes impurity, obtain Aloe original juice;
S3: put in vacuum-concentrcted device by Aloe original juice liquid and concentrate, concentrated 2 ~ 3 times of circulation, obtains Aloe extract.
5. whitening skin and preserving moisture facial cream as claimed in claim 1, it is characterized in that, described mixed extract is obtained by following steps:
Get Semen Coicis 3 ~ 6 parts, Radix Asparagi 3 ~ 6 parts and Ganoderma 3 ~ 6 parts, coarse powder is ground into after mixing, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding 15 ~ 25 parts by weight is the alcoholic solution of 75 ~ 85%, regulation and control carbon dioxide flow is 12 ~ 15L/h, and extracting pressure is 12 ~ 15MPa, and extraction temperature is 40 ~ 60 DEG C, extraction time is 3 ~ 7 hours, and decompression separation obtains described mixed extract.
6. whitening skin and preserving moisture facial cream as claimed in claim 1, it is characterized in that, be made up of the component of following parts by weight: hyaluronic acid 3 ~ 9 parts, 2 ~ 5 parts, gelatin, stearoxyl trimethyl silane 2 ~ 5 parts, glycerol 2 ~ 5 parts, Natrulon H-10 1 ~ 5 part, sodium cocoyl glycinate 0.2 ~ 1 part, betanin 0.2 ~ 1 part, Cortex Eucommiae extract 6 ~ 12 parts, Aloe extract 3 ~ 6 parts, mixed extract 9 ~ 18 parts, EDETATE SODIUM 0 ~ 0.5 part, 0.01 ~ 0.2 part, essence, white vaseline 1 ~ 5 part and 40 ~ 60 parts, water.
7. whitening skin and preserving moisture facial cream as claimed in claim 6, it is characterized in that, be made up of the component of following parts by weight: hyaluronic acid 6 parts, 3 parts, gelatin, stearoxyl trimethyl silane 3 parts, glycerol 3 parts, Natrulon H-10 2 parts, sodium cocoyl glycinate 0.5 part, betanin 0.5 part, Cortex Eucommiae extract 8 parts, Aloe extract 4 parts, mixed extract 15 parts, EDETATE SODIUM 0.5 part, 0.2 part, essence, white vaseline 3 parts and 50 parts, water.
8. the preparation method of whitening skin and preserving moisture facial cream as claimed in claim 1, is characterized in that, comprise the following steps:
S1: thickening agent, white vaseline are placed in oil phase pot, are heated to 75 ~ 90 DEG C, obtain material A after stirring and dissolving is complete, the mixing speed of stirring is 40 ~ 50r/min, and insulation is for subsequent use;
S2: wetting agent, water are heated to 85 ~ 90 DEG C and dissolve completely, in the emulsifying pot of then suction preheating, opens and stirs, the mixing speed stirred is 40 ~ 50r/min, again by slow for material A suction emulsifying pot, lower the temperature after homogenizing 10 ~ 15min, the rotating speed of homogenizing is 2000 ~ 3000rpm;
S3: be down to 60 DEG C, add additive, homogenizing 3 ~ 8min;
S4: continue to be cooled to 40 DEG C, add Chinese medicine extract and be stirred to evenly, sampling Detection, namely qualified rear discharging obtains whitening skin and preserving moisture facial cream.
9. the preparation method of whitening skin and preserving moisture facial cream as claimed in claim 8, it is characterized in that, described Chinese medicine extract is obtained by following steps:
S1: take the Cortex Eucommiae by 6 ~ 12 parts by weight, pulverizes mixing after cleaning, drying, and add the water soaking 35 ~ 60 minutes of medical material gross weight 6 ~ 10 times amount, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, filters and retain filtering residue, merging filtrate, obtaining Aqueous extracts; In filtering residue, add medical material gross weight 6 ~ 10 times amount volume fraction is the ethanol of 60 ~ 85%, reflux, extract, 1 ~ 2 time, each 4 ~ 7 hours, and filter, merging filtrate, obtains alcohol extract; Merge Aqueous extracts and alcohol extract, after stirring, leave standstill 12 ~ 24 hours, centrifugal 15 ~ 20 minutes of 2000g, gets supernatant, carries out hyperfiltration treatment, temperature is 36 ~ 45 DEG C, and material liquid pH is 6 ~ 8, and inlet pressure is 0.3MPa, the low 0.35kPa of liquid outlet pressure ratio inlet pressure, the pressure wave moment of periodic pressure fluctuation is 0.2 ~ 0.3MPa, when feed liquid stock solution reduces 1/10 ~ 1/4, then the ultrafiltration 1 ~ 3 time that adds water, merge ultrafiltrate, obtain Cortex Eucommiae extract;
S2: take Semen Coicis 3 ~ 6 parts, Radix Asparagi 3 ~ 6 parts and Ganoderma 3 ~ 6 parts, coarse powder is ground into after mixing, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding 15 ~ 25 parts by weight is the alcoholic solution of 75 ~ 85%, regulation and control carbon dioxide flow is 12 ~ 15L/h, and extracting pressure is 12 ~ 15MPa, and extraction temperature is 40 ~ 60 DEG C, extraction time is 3 ~ 7 hours, and decompression separation obtains described mixed extract;
S3: get Aloe 3 ~ 6 parts, cleans, and after drying, is squeezed obtain Aloe mixing juice with squeezer; The Aloe obtained mixing juice is put in filtering tank, removes impurity, obtain Aloe original juice; Put in vacuum-concentrcted device by Aloe original juice liquid and concentrate, concentrated 2 ~ 3 times of circulation, obtains Aloe extract;
S4: Cortex Eucommiae extract, mixed extract and Aloe extract are merged and obtains described Chinese medicine extract.
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| CN110123720A (en) * | 2019-06-15 | 2019-08-16 | 福建农林大学 | A kind of konjaku glucomannan care face cream and preparation method thereof |
| CN110218656A (en) * | 2019-05-31 | 2019-09-10 | 南京工业大学 | The two-way solid fermentation method of ganoderma lucidum-dregs of a decoction and application using air pressure pulsation |
| CN111297779A (en) * | 2020-03-30 | 2020-06-19 | 上海黛安生物科技有限公司 | Vitamin C crystal powder |
| CN113143788A (en) * | 2021-05-18 | 2021-07-23 | 广州欣蔓化妆品有限公司 | Multi-effect composition and face cream with moisturizing, repairing and relieving functions |
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| CN115364021A (en) * | 2021-11-23 | 2022-11-22 | 广州市百爱神生物科技有限公司 | Cream containing supercritical plant extract and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653136A (en) * | 2018-06-26 | 2018-10-16 | 戴伟 | A kind of Chinese medicine composition and its mixed extract being used for cosmetics frost breast and facial mask |
| CN110218656A (en) * | 2019-05-31 | 2019-09-10 | 南京工业大学 | The two-way solid fermentation method of ganoderma lucidum-dregs of a decoction and application using air pressure pulsation |
| CN110123720A (en) * | 2019-06-15 | 2019-08-16 | 福建农林大学 | A kind of konjaku glucomannan care face cream and preparation method thereof |
| CN111297779A (en) * | 2020-03-30 | 2020-06-19 | 上海黛安生物科技有限公司 | Vitamin C crystal powder |
| CN113143788A (en) * | 2021-05-18 | 2021-07-23 | 广州欣蔓化妆品有限公司 | Multi-effect composition and face cream with moisturizing, repairing and relieving functions |
| CN115364021A (en) * | 2021-11-23 | 2022-11-22 | 广州市百爱神生物科技有限公司 | Cream containing supercritical plant extract and preparation method thereof |
| CN115364021B (en) * | 2021-11-23 | 2024-02-13 | 广州市百爱神生物科技有限公司 | A cream containing supercritical plant extract and its preparation method |
| CN114983878A (en) * | 2022-07-18 | 2022-09-02 | 中国医学科学院药用植物研究所 | Natural multifunctional moisturizing, whitening and anti-aging face cream and preparation method thereof |
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