CN108294973A - Body whitening crème - Google Patents
Body whitening crème Download PDFInfo
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- CN108294973A CN108294973A CN201810262418.8A CN201810262418A CN108294973A CN 108294973 A CN108294973 A CN 108294973A CN 201810262418 A CN201810262418 A CN 201810262418A CN 108294973 A CN108294973 A CN 108294973A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses the raw materials of a kind of body whitening crème, including following weight parts to be prepared：40 60 parts of water, 26 parts of glycerine, 13 parts of 1,3 butanediol, 15 parts of ring five dimethyl silicone polymer, 13 parts of surfactant, 0.02 0.06 parts of Ascorbyl Tetraisopalmitate, 0.02 0.06 parts of caprylic/capric triglyceride, 0.02 0.06 parts of niacinamide, 0.03 0.09 parts of Licochalcone A, 0.02 0.06 parts of allantoin, 0.02 0.06 parts of tocopherol acetate, 12 parts of lanolin, 26 parts of dormant oil.There is the body whitening crème of the present invention efficient hydroxy radical to eliminate active function, obviously feels comfortable after use, is soft, no greasy feeling, the melanin on skin can be effectively eliminated, skin whitening can make skin smooth beautiful, wrinkle is prevented, to no skin irritation；Have the effect of apparent sun-proof reparation, moistening skin-care.
Description
Technical field
The present invention relates to a kind of body whitening crème.
Background technology
The Cosmetic Market of China is the maximum emerging market in the whole world, in short more than 20 years, China cosmetic row
Industry from small to large, grows from weak to strong, from simple extensive to lead in the development of science and technology, grouping management, the whole industry form one begin to take shape,
It is rich in the army of industrial workers of life vigor.
Skin cream is a kind of emulsifying cream, there is O/W types, w/o type and W/O/W types.Oil components contained by skin cream are situated between
Between toilet cream and face cream, being suitable for for various oil phase-watr-proportions can be configured in the range of oil phase and water phase respectively
The product of various types skin, raw material used by skin cream is quite extensive, therefore skin cream product is varied, big absolutely at present
Most skin care creams belong to such product.
Chinese patent (application number：201611241507.1) disclose a kind of freckle removing and whitening moisturizing cosmetics formula and its system
Preparation Method, it includes the raw material of following mass fraction：10-50 parts of matrimony vine, 10-60 parts of tea-seed oil, 5-30 parts of the root of Dahurain angelica, grape seed oil
5-40 parts, 1-6 parts of peppermint oil, 1-6 parts of rose oil.Preparation method is that the root of Dahurain angelica and drying of Chinese wolfberry and grind into powder are taken one
A clean container, angelica dahurica powder and wolfberry fruit powder are put into container, and tea-seed oil, grape seed oil, thin is added by definite quality number
Lotus oil, rose oil, stir evenly；Then container is placed on electric furnace and is heated, keep 70-95 DEG C of temperature, continue 30-60 points
Clock is carried out in heating process continuing stirring, be cooled down to get freckle removing and whitening moisturizing cosmetics after the completion of heating.
Chinese patent (application number：201110035887.4) a kind of Daffodil whitening cream cosmetic is disclosed, by weight,
Including following raw material：3-5 parts of daffodil bulb extract, 6.1-11 parts of whitening agent；3.1-7.4 parts of thickener；Emollient 8-15
Part；1.5-5 parts of emulsifier；0.5-1 parts of anti-sensitizer；8.01-12.1 parts of moisturizer；0.1-0.3 parts of preservative；Essence 0.03-0.1
Part；With 75-110 parts of water.
As people’s lives level increasingly improves, also increasingly to the quality requirements of the cosmetics such as beauty, skin-protection product
It is high.Skin-protection product available on the market is although various, but many products are more or less added to some harmful objects
Matter：Such as bleaching powder, mercury, detergent, corrosive agent.Although these substances have short-term whitening, skin care effect to the skin of people,
If be used for a long time, skin can be made to form color spot instead, seriously, it could even be possible to causing human organ that lesion occurs.People
There is also a desire for superior moisturizing repair cream.
Invention content
The purpose of the present invention is to provide a kind of body whitening crème, the prior art is overcome the problems, such as there are above-mentioned, with skin
Compatibility is good, and functional component in cosmetics can be promoted to penetrate epidermis, plays skin nursing effect.
Technical solution is used by solving above-mentioned technical problem：
A kind of body whitening crème, including the raw material of following weight parts are prepared：40-60 parts of water, 2-6 parts of glycerine, 1,3-
1-3 parts of butanediol, ring five dimethyl silicone polymer (No. CAS：541-02-6) 1-5 parts, 1-3 parts of surfactant, ascorbic acid
Four different palmitates CAS：183476-82-6) 0.02-0.06 parts, caprylic/capric triglyceride (No. CAS：65381-09-1)
0.02-0.06 parts, niacinamide (No. CAS：98-92-0) 0.02-0.06 parts, Licochalcone A (No. CAS：58749-22-7)
0.03-0.09 parts, allantoin (No. CAS：97-59-6) 0.02-0.06 parts, tocopherol acetate (No. CAS：7695-91-2)
0.02-0.06 parts, lanolin (No. CAS：8006-54-0) 1-2 parts, dormant oil (No. CAS：8012-95-1) 2-6 parts.
Preferably, the surfactant is zwitterionic surfactant, nonionic surfactant or anion table
Face activating agent.
It is further preferred that the surfactant is lauryl sodium sulfate, polyvinyl chloride alkylcarbonic acid sodium, acyl group sulphur
The dodecyl sugar amide surface that sour sodium, sulfosuccinic acid esters surfactant, polyphenol surfactant, ethyoxyl are modified is lived
Property agent, alkyl phosphoric acid lipid surfactant, acyl group sarcosine and its type surfactant, lauroyl aminocarbonyl propyl beet
Alkali, amine-oxides, amino acid type surfactant, imidazoline, alkylolamides, alkyl poly glucoside and plant surface activating agent
In or mixtures thereof one kind.
Still further preferably, the biosurfactant is the ten of polyphenol surfactant and/or ethyoxyl modification
Dialkyl group sugar acidamide surfactant.
Specifically, the polyphenol surfactant is prepared by following methods：Take 95-105g tea polyphenols, 75-85g hexylamines,
20-30g decanoyl chlorides be added 180-220mL methanol in, temperature be 35-55 DEG C with rotating speed be 60-180r/min stir 15-25h,
It is cooled to 0 DEG C with ice water, 90-110g sodium borohydrides are added, is that 60-180r/min stirs 40-90min with rotating speed, uses 0.2-
1mol/L salt acid for adjusting pH is that 30-90r/min is stirred to no Precipitation with rotating speed, filters and collect filter cake, filter to 1-2
Cake ethyl alcohol and water wash 2-4 times respectively, and in the case where temperature is 40-50 DEG C, vacuum degree is 100-150Pa, dry 1.5-3.5h, obtains
To a product；It is 1 in mass ratio by a product and methanol：(3-7) is mixed, and in the case where rotating speed is 30-90r/min stirrings, is risen
Temperature is back to no white precipitate and is precipitated, and filters and collect filter cake, and filter cake ethyl alcohol and water wash 2-4 times respectively, is 40- in temperature
50 DEG C, vacuum degree be dry 2.5-5.5h under 100-150Pa, obtain intermediate product；By intermediate product, methanol, diethylene glycol two
Glycidol ether is 1 in mass ratio：(6-9)：(1-2) is mixed, heating in water bath for reaction 20-25h at a temperature of 70-80 DEG C, then
Vacuum distillation removal methanol, in the case where temperature is 40-50 DEG C, vacuum degree is 100-150Pa, dry 5-10h is to get the polyphenol table
Face activating agent.
Specifically, the alkyl sugar acidamide surfactant that the ethyoxyl is modified is prepared by following methods：
Alkyl diamine and alkyl halide react at a temperature of 60-150 DEG C；The mol ratio of alkyl diamine and alkyl halide is (1-
20): 1, after the completion of reaction, mixture stratification, upper layer vacuum distillation obtains N- alkyl diamines；
Above-mentioned N- alkyl diamines and saccharic acid or saccharic acid lactone react at a temperature of 60-150 DEG C, N- alkyl diamines and saccharic acid or
The mol ratio of saccharic acid lactone is (1-2)：1, after the completion of reaction, solvent is evaporated, alkyl sugar amide is obtained；
The alkyl sugar amide and dihydric alcohol methyl ether glycidol ether react at a temperature of 60-150 DEG C；Alkyl sugar amide with
The mol ratio of dihydric alcohol methyl ether glycidol ether is (1-2)：1, after the completion of reaction, solvent is evaporated, the ethyoxyl is obtained and changes
The alkyl sugar acidamide surfactant of property.
The alkyl diamine is ethylenediamine, 1,3- propane diamine, Putriscine, 1,5- pentanediamines or 1,6- hexamethylene diamines.
The alkyl halide be chloro-hexane, chloro octane, chloro decane, chlorinated dodecane, bromooctane, bromodecane,
Bromododecane or iodohexadecane.
The saccharic acid or saccharic acid lactone are gluconic acid or glucolactone, lactobionic acid or lactobionolactone, mannose
Acid or mannonic acid lactone etc..
The dihydric alcohol methyl ether glycidol ether is ethylene glycol monomethyl ether glycidol ether, diethylene glycol dimethyl ether glycidol
Ether, triethylene glycol methyl ether glycidol ether, tetraethylene glycol methyl ether glycidol ether or six ethylene glycol monomethyl ether glycidol ethers.
As dodecyl most preferred, that the biosurfactant is modified by polyphenol surfactant, ethyoxyl
Sugared acidamide surfactant is 1 in mass ratio：(0.2-0.6) is formed.
Above-mentioned whitening and moistening skin maintenance frost body whitening crème may be used this field conventional method and be prepared, such as can adopt
Use following steps：
(1) 1,3-BDO, surfactant and water are added in water phase pot and are uniformly mixed, be warming up to 65-85 DEG C,
Obtain water phase material；
(2) by glycerine, ring five dimethyl silicone polymer, Ascorbyl Tetraisopalmitate, caprylic/capric triglyceride,
Niacinamide, Licochalcone A, allantoin, tocopherol acetate, lanolin and dormant oil are added in oil phase pot, are heated to 65-85 DEG C
It is uniformly mixed, obtains oil phase material；
(3) water phase material is pumped into emulsification pot, stirs and is pumped into oil phase material, homogeneous 5-15 at a temperature of 65-85 DEG C under homogeneous
Minute to get.
Technique effect：There is the body whitening crème of the present invention efficient hydroxy radical to eliminate active function, apparent after use
It feels comfortable, is soft, no greasy feeling can effectively eliminate the melanin on skin, and skin whitening can make skin smooth beautiful,
Wrinkle is prevented, to no skin irritation；Have the effect of apparent sun-proof reparation, moistening skin-care.
Specific implementation mode
Homogeneous emulsifying machine is the model VME- that Guangzhou combines that automated machine Science and Technology Ltd. provides in embodiment
The vacuum homogeneous emulsifying machine of 300L.
The preparation method of polyphenol surfactant is as follows in embodiment：Taking 100g tea polyphenols, (Shaanxi sky occasion biotechnology has
Limit company provide, appearance be light green brown color or brownish red fine powder, polyphenol content 98wt%), 80g hexylamines, the 25g last of the ten Heavenly stems
Acyl chlorides is added in 200mL methanol, in temperature be 45 DEG C with rotating speed is that 120r/min stirs 20h, is cooled to 0 DEG C with ice water, is added
100g sodium borohydrides, it is 60r/ with rotating speed to stir 50min with 0.5mol/L salt acid for adjusting pH to 1.5 with rotating speed for 120r/min
Min is stirred to no Precipitation, filters and collect filter cake, and filter cake ethyl alcohol and water wash 3 times respectively, every time wash ethyl alcohol or
The dosage of water is 20mL, and in the case where temperature is 45 DEG C, vacuum degree is 130Pa, dry 2.5h, obtains a product；By a product
It is 1 in mass ratio with methanol：5 mixing, in the case where rotating speed is 60r/min stirrings, temperature rising reflux to no white precipitate is precipitated, and filters simultaneously
Filter cake is collected, filter cake ethyl alcohol and water wash 4 times respectively, and it is 20mL to wash ethyl alcohol or the dosage of water every time, are 45 in temperature
DEG C, vacuum degree be dry 4h under 130Pa, obtain intermediate product；Intermediate product, methanol, diethylene glycol diglycidyl glycerin ether are pressed
Mass ratio is 1：7.5：1.2 mixing, heating in water bath for reaction 23h at a temperature of 75 DEG C, then vacuum distillation removes methanol, in temperature
It is that 7h is dried under 130Pa to get polyphenol surfactant for 45 DEG C, vacuum degree.
In embodiment ethyoxyl be modified dodecyl sugar acidamide surfactant according to application No. is
201410336291.1 Chinese patent in method shown in embodiment 6 prepare.
Dormant oil uses 15# White Mineral Oils in embodiment.
Embodiment 1
A kind of body whitening crème, including the raw material of following weight parts are prepared：50 parts of water, 4 parts of glycerine, 1,3 butylene glycol
2 parts, 3 parts of ring five dimethyl silicone polymer, 2 parts of polyphenol surfactant, 0.04 part of Ascorbyl Tetraisopalmitate, octanoic acid/
0.04 part of Triglyceride DDD, 0.04 part of niacinamide, 0.06 part of Licochalcone A, 0.04 part of allantoin, tocopherol acetate
0.04 part, 1.5 parts of lanolin, 4 parts of dormant oil.
Using following steps：
(1) 1,3-BDO, polyphenol surfactant and water are added in water phase pot and are uniformly mixed, be warming up to 75
DEG C, obtain water phase material；
(2) by glycerine, ring five dimethyl silicone polymer, Ascorbyl Tetraisopalmitate, caprylic/capric triglyceride,
Niacinamide, Licochalcone A, allantoin, tocopherol acetate, lanolin and dormant oil are added in oil phase pot, are heated to 75 DEG C and stir
It mixes uniformly mixed, obtains oil phase material；
(3) water phase material is pumped into emulsification pot, stirs and is pumped into oil phase material under homogeneous, the homogeneous 10 minutes at a temperature of 75 DEG C,
Up to the body whitening crème of the present invention.
Embodiment 2
A kind of body whitening crème, including the raw material of following weight parts are prepared：50 parts of water, 4 parts of glycerine, 1,3 butylene glycol
2 parts, 3 parts of ring five dimethyl silicone polymer, ethyoxyl be modified 2 parts of dodecyl sugar acidamide surfactant, ascorbic acid four
0.04 part of different palmitate, 0.04 part of caprylic/capric triglyceride, 0.04 part of niacinamide, 0.06 part of Licochalcone A, allantois
0.04 part of element, 0.04 part of tocopherol acetate, 1.5 parts of lanolin, 4 parts of dormant oil.
Using following steps：
(1) dodecyl sugar acidamide surfactant and water that 1,3 butylene glycol, ethyoxyl are modified are added in water phase pot
It is uniformly mixed, is warming up to 75 DEG C, obtain water phase material；
(2) by glycerine, ring five dimethyl silicone polymer, Ascorbyl Tetraisopalmitate, caprylic/capric triglyceride,
Niacinamide, Licochalcone A, allantoin, tocopherol acetate, lanolin and dormant oil are added in oil phase pot, are heated to 75 DEG C and stir
It mixes uniformly mixed, obtains oil phase material；
(3) water phase material is pumped into emulsification pot, stirs and is pumped into oil phase material under homogeneous, the homogeneous 10 minutes at a temperature of 75 DEG C,
Up to the body whitening crème of the present invention.
Embodiment 3
A kind of body whitening crème, including the raw material of following weight parts are prepared：50 parts of water, 4 parts of glycerine, 1,3 butylene glycol
2 parts, 3 parts of ring five dimethyl silicone polymer, 1.5 parts of polyphenol surfactant, ethyoxyl be modified dodecyl sugar amide surface
0.5 part of activating agent, 0.04 part of Ascorbyl Tetraisopalmitate, 0.04 part of caprylic/capric triglyceride, 0.04 part of niacinamide,
0.06 part of Licochalcone A, 0.04 part of allantoin, 0.04 part of tocopherol acetate, 1.5 parts of lanolin, 4 parts of dormant oil.
Using following steps：
(1) by 1,3 butylene glycol, polyphenol surfactant, ethyoxyl be modified dodecyl sugar acidamide surfactant and
Water is added in water phase pot and is uniformly mixed, and is warming up to 75 DEG C, obtains water phase material；
(2) by glycerine, ring five dimethyl silicone polymer, Ascorbyl Tetraisopalmitate, caprylic/capric triglyceride,
Niacinamide, Licochalcone A, allantoin, tocopherol acetate, lanolin and dormant oil are added in oil phase pot, are heated to 75 DEG C and stir
It mixes uniformly mixed, obtains oil phase material；
(3) water phase material is pumped into emulsification pot, stirs and is pumped into oil phase material under homogeneous, the homogeneous 10 minutes at a temperature of 75 DEG C,
Up to the body whitening crème of the present invention.
Embodiment 4
A kind of body whitening crème, including the raw material of following weight parts are prepared：50 parts of water, 4 parts of glycerine, 1,3 butylene glycol
2 parts, 3 parts of ring five dimethyl silicone polymer, 2 parts of lauroyl amido propyl betaine, 0.04 part of Ascorbyl Tetraisopalmitate,
0.04 part of caprylic/capric triglyceride, 0.04 part of niacinamide, 0.06 part of Licochalcone A, 0.04 part of allantoin, tocopherol second
0.04 part of acid esters, 1.5 parts of lanolin, 4 parts of dormant oil.
Using following steps：
(1) 1,3-BDO, lauroyl amido propyl betaine and water are added in water phase pot and are uniformly mixed, heated up
To 75 DEG C, water phase material is obtained；
(2) by glycerine, ring five dimethyl silicone polymer, Ascorbyl Tetraisopalmitate, caprylic/capric triglyceride,
Niacinamide, Licochalcone A, allantoin, tocopherol acetate, lanolin and dormant oil are added in oil phase pot, are heated to 75 DEG C and stir
It mixes uniformly mixed, obtains oil phase material；
(3) water phase material is pumped into emulsification pot, stirs and is pumped into oil phase material under homogeneous, the homogeneous 10 minutes at a temperature of 75 DEG C,
Up to the body whitening crème of the present invention.
Test case 1
The removing free radical performance of body whitening crème prepared by embodiment 1-4 is tested.
Remove free radical experiment：
Body whitening crème is made into the sample solution that mass concentration is 0.5% with water, is tested.Take 0.05mol/L pH
=8.2 Tris-HCl buffer solution 4.5mL, 20min is preheated in 20 DEG C of water-baths.Add 1mL sample solutions and 0.4mL
The pyrogallol solution of 25mmol/L after mixing, reacts 5min in 20 DEG C of water-baths, and the HCl 1.0mL that 8mol/L is added are terminated
Reaction.Make reference with Tris-HCl buffer solutions, absorbance value is surveyed at 299nm.Blank control substitutes sample with 1mL water.It presses
Illuminated (2) calculates clearance rate (D).
Ultra-oxygen anion free radical clearance rate (%)=[1- (A2/A1)] × 100%.
In formula：A1 is the absorbance value of blank control；A2 is the absorbance value of sample.
Specific test result is shown in Table 1.
Table 1：Remove free radical test result table
| Ultra-oxygen anion free radical clearance rate (%) | |
| Embodiment 1 | 90.2 |
| Embodiment 2 | 88.3 |
| Embodiment 3 | 94.8 |
| Embodiment 4 | 86.1 |
Test case 2
The performance of keeping humidity of body whitening crème prepared by embodiment 1-4 is tested.
Performance of keeping humidity is tested：It is tested using keratoderma hydration rate, instrument used is Corneometer CM825,
By measuring the variation of water content of stratum corneum is weighed using the variation of keratoderma capacitance before and after product, to evaluate
Moisture-keeping efficacy.Test method：120 female subjects are randomly divided into 4 groups, every group 30, the age：20-30 Sui 10,30-
40 years old 10,40-50 Sui 10, subject or so forearm bend side mark 3 × 3cm2The square Experimental Area of size, with a left side
Test zone of the arm as body whitening crème, uniform smearing body whitening crème 0.12g every square centimeter, right arm symmetrical area accordingly
Domain is blank control, experiment position after then using Corneometer CM825 test detections to smear 8 hours of body whitening crème
Moisture is repeated 5 times respectively, obtains average value, calculated hydration rate.Hydration rate (%)=(test value-blank value)/blank value
×100。
Specific test result is shown in Table 2.Each group comparison result shows that P ＜ 0.05, difference have statistical significance.
Table 2：Performance of keeping humidity test result table
| Hydration rate, % | |
| Embodiment 1 | 75 |
| Embodiment 2 | 71 |
| Embodiment 3 | 80 |
| Embodiment 4 | 66 |
Test case 3
The sun-proof result of body whitening crème prepared by embodiment 1-4 is tested.
Blank quartz board test background curve, then precise 0.2mg/cm are used before test2Sample on 3M adhesive tapes face,
Then with the finger rapid application homogeneous sample for taking latex finger cot.Sample panel after smearing is spontaneously dried with shady place
25min, then using ultraviolet ray transmissivity analyzer, (the SPF-290AS ultraviolet lights of Solarlight companies of U.S. production penetrate
Rate analyzer) in measure, you can the sun-proof value for measuring UVB is indicated with spf value.Spf value is determined according to minimum Erythema Dose
's：The minimum Erythema Doses of SPF=(after sun-proof articles)/minimum Erythema Dose (with before sun-proof articles)；The number of SPF sun protection factor
Value is suitable for everyone, and computational methods are：Assuming that the intensity of ultraviolet light will not change because of the time, one without any sun-proof
If the people of measure skin after 20min in the sun can redden, when he uses SPF15 sunscreen products, expression can extend 15 times
Time, that is, skin just can be by turn to red because of sun burn after 300min.
Specific test result is shown in Table 3.Each group comparison result shows that P ＜ 0.05, difference have statistical significance.
Table 3：Sun-proof result test result table
| Spf value | |
| Embodiment 1 | 37 |
| Embodiment 2 | 36 |
| Embodiment 3 | 44 |
| Embodiment 4 | 32 |
Test case 4：
Using middle melanin genesis in the inhibition mouse melanin cell disclosed in ZL201310569535.6 effect examples
Experiment, is tested.Specific test result is shown in Table 4.
Table 4：Inhibiting rate test result table
| Spf value | |
| Embodiment 1 | 62.7 |
| Embodiment 2 | 62.3 |
| Embodiment 3 | 65.3 |
| Embodiment 4 | 60.8 |
Above-mentioned test result shows that body whitening crème of the invention can effectively inhibit melanin production, and with obvious effects.
There is the body whitening crème of the present invention efficient hydroxy radical to eliminate active function, obviously feel comfortable after use,
Softness, no greasy feeling can effectively eliminate the melanin on skin, and skin whitening can make skin smooth beautiful, prevent to wrinkle
Line, to no skin irritation；Have the effect of apparent sun-proof reparation, moistening skin-care.
Claims (6)
1. a kind of body whitening crème, including the raw material of following weight parts are prepared：40-60 parts of water, 2-6 parts of glycerine, 1,3- fourths
1-3 parts of glycol, 1-5 parts of ring five dimethyl silicone polymer, 1-3 parts of surfactant, Ascorbyl Tetraisopalmitate 0.02-
0.06 part, 0.02-0.06 parts of caprylic/capric triglyceride, 0.02-0.06 parts of niacinamide, Licochalcone A 0.03-0.09
Part, 0.02-0.06 parts of allantoin, 0.02-0.06 parts of tocopherol acetate, 1-2 parts of lanolin, 2-6 parts of dormant oil.
2. body whitening crème as described in claim 1, which is characterized in that the surfactant is amphoteric ion surface-active
Agent, nonionic surfactant or anion surfactant.
3. body whitening crème as claimed in claim 2, which is characterized in that the surfactant be lauryl sodium sulfate,
Polyvinyl chloride alkylcarbonic acid sodium, acyl group sodium sulfonate, sulfosuccinic acid esters surfactant, polyphenol surfactant, ethyoxyl
Modified dodecyl sugar acidamide surfactant, alkyl phosphoric acid lipid surfactant, acyl group sarcosine and its esters surface
Activating agent, lauroyl amido propyl betaine, amine-oxides, amino acid type surfactant, imidazoline, alkylolamides, alkyl
Or mixtures thereof one kind in poly glucoside and plant surface activating agent.
4. body whitening crème as claimed in claim 3, which is characterized in that the surfactant is polyphenol surfactant
And/or the dodecyl sugar acidamide surfactant that ethyoxyl is modified.
5. body whitening crème as claimed in claim 4, which is characterized in that the polyphenol surfactant is by following methods system
It is standby：
It takes 95-105g tea polyphenols, 75-85g hexylamines, 20-30g decanoyl chlorides to be added in 180-220mL methanol, is 35-55 in temperature
DEG C it is that 60-180r/min stirs 15-25h with rotating speed, is cooled to 0 DEG C with ice water, 90-110g sodium borohydrides are added, are with rotating speed
60-180r/min stirs 40-90min, with 0.2-1mol/L salt acid for adjusting pH to 1-2, with rotating speed be 30-90r/min stir to
After Precipitation, filter cake is filtered and collects, filter cake ethyl alcohol and water wash 2-4 times respectively, are 40-50 DEG C, vacuum in temperature
Degree is dry 1.5-3.5h under 100-150Pa, obtains a product；It is 1 in mass ratio by a product and methanol：(3-7) is mixed
It closes, in the case where rotating speed is 30-90r/min stirrings, temperature rising reflux to no white precipitate is precipitated, and filters and collect filter cake, filter cake second
Alcohol and water washs 2-4 times respectively, and in the case where temperature is 40-50 DEG C, vacuum degree is 100-150Pa, dry 2.5-5.5h, obtains centre
Product；It is 1 in mass ratio by intermediate product, methanol, diethylene glycol diglycidyl glycerin ether：(6-9)：(1-2) is mixed, in 70-80
Heating in water bath for reaction 20-25h at a temperature of DEG C, then vacuum distillation removal methanol, temperature be 40-50 DEG C, vacuum degree 100-
Dry 5-10h is to get the polyphenol surfactant under 150Pa.
6. body whitening crème as claimed in claim 4, which is characterized in that the alkyl sugar amide surface that the ethyoxyl is modified is lived
Property agent is prepared by following methods：
Alkyl diamine and alkyl halide react at a temperature of 60-150 DEG C；The mol ratio of alkyl diamine and alkyl halide is (1-20): 1,
After the completion of reaction, mixture stratification, upper layer vacuum distillation obtains N- alkyl diamines；
Above-mentioned N- alkyl diamines and saccharic acid or saccharic acid lactone react at a temperature of 60-150 DEG C, N- alkyl diamines and saccharic acid or saccharic acid
The mol ratio of lactone is (1-2)：1, after the completion of reaction, solvent is evaporated, alkyl sugar amide is obtained；
The alkyl sugar amide and dihydric alcohol methyl ether glycidol ether react at a temperature of 60-150 DEG C；Alkyl sugar amide and binary
The mol ratio of alcohol methyl ether glycidol ether is (1-2)：1, after the completion of reaction, solvent is evaporated, obtains what the ethyoxyl was modified
Alkyl sugar acidamide surfactant.
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| CN111297761A (en) * | 2020-04-13 | 2020-06-19 | 北京悠悦百仕科技发展有限公司 | Whitening composition and preparation method and application thereof |
| FR3110408A1 (en) * | 2020-05-20 | 2021-11-26 | Laboratoire Dermatologique Inderma | ACTIVE COMPLEX AGAINST SKIN COLORING AND PIGMENTATION AND COSMETIC APPLICATIONS |
| CN113768801A (en) * | 2021-08-18 | 2021-12-10 | 广州斑消宝化妆品有限公司 | Skin moistening oil and preparation method thereof |
| CN113975215A (en) * | 2021-11-18 | 2022-01-28 | 广州梵之容化妆品有限公司 | Whitening cream and preparation method thereof |
| CN114053171A (en) * | 2021-12-08 | 2022-02-18 | 上海纳米技术及应用国家工程研究中心有限公司 | Whitening essence and preparation method and application thereof |
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| CN111297761A (en) * | 2020-04-13 | 2020-06-19 | 北京悠悦百仕科技发展有限公司 | Whitening composition and preparation method and application thereof |
| FR3110408A1 (en) * | 2020-05-20 | 2021-11-26 | Laboratoire Dermatologique Inderma | ACTIVE COMPLEX AGAINST SKIN COLORING AND PIGMENTATION AND COSMETIC APPLICATIONS |
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| CN113975215A (en) * | 2021-11-18 | 2022-01-28 | 广州梵之容化妆品有限公司 | Whitening cream and preparation method thereof |
| CN114053171A (en) * | 2021-12-08 | 2022-02-18 | 上海纳米技术及应用国家工程研究中心有限公司 | Whitening essence and preparation method and application thereof |
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| CN108294973B (en) | 2021-06-11 |
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