CN109620782A - A kind of plant composition with Whitening, spot effect - Google Patents
A kind of plant composition with Whitening, spot effect Download PDFInfo
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- CN109620782A CN109620782A CN201811302609.9A CN201811302609A CN109620782A CN 109620782 A CN109620782 A CN 109620782A CN 201811302609 A CN201811302609 A CN 201811302609A CN 109620782 A CN109620782 A CN 109620782A
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- whitening
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- plant composition
- spot
- glabridin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The present invention relates to cosmetic technical fields, more particularly to a kind of plant composition with Whitening, spot effect, the plant composition includes following raw material: 10 ~ 100 parts of glabridin extracting solution, 10 ~ 80 parts of Vitamin C glycosides, 20 ~ 60 parts of niacinamide.Whitening, spot plant composition of the present invention passes through rational proportion, make to generate synergistic function between Whitening, spot plant composition component, when overcoming the shortcomings of respective exclusive use, compared to the whitening and skin-protecting product containing only single active constituent or double activated or three active components, the whitening effect of the product containing the plant composition is more fully efficient.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of plant composition with Whitening, spot effect and its
Preparation method.
Background technique
Color spot, that is, cutaneous pigmentation belongs to dyschromicum skin disease.Color spot is formed as a variety of causes, such as ultraviolet
Line irradiation, inherent cause, drug factors, gestation etc. cause hyperpigmentation in skin not to be metabolized in time, so that melanin
It is calm and be unevenly distributed.Melanin is a kind of biochrome, is present among the cell of skin base layer.When chromoplast by
To when the stimulations such as ultraviolet light, skin would be at the state of " self-protection ", and chromoplast accelerates secretion Mai Laning pigment, swashs
The activity of tyrosinase living protects our Skin Cell.Under normal conditions, predecessor's DOPA of melanin is through oxidizing tyrosine
Afterwards, melanin is released, then moving layer by layer via cell metabolism, has arrived skin epidermis and has formd freckle, sunburn, black
Spot etc..Therefore, when carrying out Whitening, spot treatment, it can set about from the generation and activity for inhibiting tyrosinase, be inhibited with this
The formation of melanin.Further, it is also possible to by melanin reduction, promote melanin metabolism and prevent ultraviolet light from the modes such as entering
Effective control to melanin pigmentation in skin is realized, to realize the effect of Whitening, spot.
Currently, the method for the treatment of can be by laser nti-freckle, although freckle effect is quick, patient needs to bear shouting pain
Sense, and easily recur, so not being optimal treatment method for the patient;Also some corrosive medicines or de- be will use
Color ointment is coated with affected part, and sore spot at skin lesion is promoted to fall off;Also useful Chinese medicine passes through enriching yin and nourishing kidney, dispersing stagnated hepatoqi, neutralization qi and blood etc.
It is equipped with systemic therapy.But these methods are not that will cause great injury to skin, and the time of but being decocted medicinal herbs using herbal treatment is long, system
Standby trouble, it is difficult to adhere to, from the ideal effect without reaching nti-freckle, whitening.
So whitening and skin-protecting is at home and abroad all concerned, and Skin whitening care cosmetics are also to emerge one after another.In order to reach whitening
Effect, the chemicals that some whitening products have used lead, mercury etc. to be harmful to the human body promote tyrosinase to inactivate, although such
Way can realize reduction melanin deposition in a short time, achieve the effect that quick Whitening, spot, but also result in skin in this way
All enzymes of skin all inactivate, even cell death, meanwhile, also hidden danger is brought to health.Therefore, effective and safe beauty
White nti-freckle product has been favored by people.
Summary of the invention
Technical problem to be solved by the present invention lies in it is good to provide a kind of whitening spot-removing excellent effect, safety in utilization
Whitening, spot plant composition and preparation method thereof.
A kind of present invention Whitening, spot plant composition to be provided, is achieved by following technical solution:
A kind of plant composition with Whitening, spot effect, is prepared comprising following raw material: glabridin extracts
10 ~ 100 parts of liquid, 10 ~ 80 parts of Vitamin C glycosides, 20 ~ 60 parts of niacinamide.
As a preferred embodiment, the Whitening, spot plant composition, is prepared comprising following raw material:
20 ~ 80 parts of glabridin extracting solution, 30 ~ 70 parts of Vitamin C glycosides, 30 ~ 50 parts of niacinamide.
As a kind of optimal case, the Whitening, spot plant composition is prepared comprising following raw material:
50 parts of glabridin extracting solution, 45 parts of Vitamin C glycosides, 40 parts of niacinamide.
As a preferred embodiment, the plant composition with Whitening, spot effect is also extracted comprising earthworm
10 ~ 50 parts by weight of object.
As a preferred embodiment, the glabridin extracting solution the preparation method comprises the following steps:
(1) take it is dry take glycyrrhiza glabra, be crushed to 60 ~ 80 mesh, be added ethanol water, refluxing extraction, filtering, filter residue uses
Same method is repeated operation, merging filtrate, rotary evaporation to paste, and addition distilled water to dipped lotion is stood overnight,
Centrifugation discards supernatant liquid, collects sediment and is dried, obtains glabridin crude extract；
(2) glabridin crude extract is purified using macroreticular resin, macroreticular resin is first successively used to the 5% of 3 ~ 4 times of volumes
NaOH solution, the distilled water of 1 ~ 1.5 times of volume, 2 ~ 3 times of volumes 10 ~ 20% hydrochloric acid washed, be then washed with distilled water to
It is neutral；Macroreticular resin is totally immersed into 90 ~ 95% ethanol solution, it is filling into column, until the ethanol solution of outflow is without white
Stop filling when muddy, then washes away ethanol solution with distilled water；In mass ratio by glabridin crude extract and dehydrated alcohol
1:10 ~ 15 dissolves, and injects in macroporous resin column, resin column diameter height ratio 1:6 ~ 10,1 ~ 3BV/h of adsorption flow rate, 2 times of cylinders of applied sample amount
Product discards aqueous with the water elution of 2 ~ 3 times of column volumes, then with 70 ~ 80% ethanol elutions of 5-6 times of column volume, collects 70-80%
Ethanol eluate merges fraction, evaporates ethyl alcohol to get glabridin extracting solution.
As a preferred embodiment, step (1) the added ethanol water mass fraction is 50 ~ 100%, and additional amount is
5 ~ 10 times of glycyrrhiza glabra quality；Return time is 1.5 ~ 2.5h；Number of operations is 2 ~ 4 times repeatedly.
As a preferred embodiment, the earthworm extract the preparation method comprises the following steps:
Earthworm leaf is taken, it is dry to constant weight, it smashes, is added in distilled water by solid-liquid ratio, microwave irradiation effect；Leaching liquor carries out water
Distillate is collected in steam distillation, after stopping distillation, by the distillate cooled and filtered, obtains earthworm extract.
As a preferred embodiment, it is the mL of 1g:20 ~ 30 that the preparation condition of the earthworm extract, which is solid-liquid ratio,；Microwave
6 ~ 8min of radiation effects, microwave power are 220 ~ 280W；The stopping distillation condition is that the quality of distillate is the raw material matter
3 ~ 6 times of amount；Distillate cooling temperature is 2 ~ 5 DEG C, and cooling time is 5 ~ 7 h.
As a preferred embodiment, the plant composition of the Whitening, spot the preparation method comprises the following steps:
First glabridin extracting solution is heated, the mixing of earthworm extract is added, continues heat temperature raising, vitamin is added again
C glucosides and niacinamide, stirring, obtain Whitening, spot plant composition.
As a preferred embodiment, the glabridin extracting solution is heated to 50 ~ 55 DEG C, and it is mixed that earthworm extract is added
Conjunction is heated to 65 ~ 75 DEG C, and the mixing speed is 1000 ~ 1200 r/min, and mixing time is 20 ~ 35min.
The utility model has the advantages that Whitening, spot plant composition of the present invention, by glabridin extracting solution, Vitamin C glycosides,
Niacinamide and earthworm extract are prepared by rational proportion, and 4 kinds of components complement each other, light to the whitening of plant composition
Spot effect generates synergistic function, so as to greatly promote the whitening effect of the skin care item, overcomes respectively individually
Deficiency when use contains the plant group compared to the whitening product containing only single active constituent or double activated or three active components
The whitening effect for closing the product of object is more fully efficient, can be used as functional additive and is added in various Skin whitening care cosmetics, shape
It is widely used at the cosmetics of the different dosage forms with excellent whitening spot-removing effect.In addition, the plant composition safety
Property it is high, have no adverse reaction, stability it is good, compensate for the commercially available insufficient obvious shortcoming of skin care item function.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described, will using above-mentioned Whitening, spot plant composition as functional additive, prepare one
For the essence cream of kind plant composition containing Whitening, spot, in conjunction with specific embodiment, the present invention is further illustrated.
But Whitening, spot plant composition of the present invention can be added to aqua, lotion, cream, essence, facial mask etc. no
With in the Skin whitening care cosmetics of dosage form.Obviously, described embodiments are some of the embodiments of the present invention, rather than whole implementation
Example.Based on the embodiments of the present invention, obtained by those of ordinary skill in the art without making creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
A kind of essence cream of the plant composition containing Whitening, spot of embodiment 1
Composition of raw materials: 1.8 parts of methyl hydroxybenzoate, 1 part of xanthan gum, 4.5 parts of nard, 6.5 parts of glycerin monostearate, propylene glycol 2
Part, 0.6 part of methyl p-hydroxybenzoate, 3.5 parts of caprylic/capric triglyceride, 1.2 parts of isohexadecane, 5 parts of butanediol, hydroxyl second
4 parts of base urea, 1.8 parts of tripeptides -1,1.3 parts of Sodium Hyaluronate, 1.4 parts of trehalose, 60 parts of water, Whitening, spot plant composition 21
Part.
The composition of the Whitening, spot plant composition: 50 parts of glabridin extracting solution, 45 parts of Vitamin C glycosides, nicotinoyl
40 parts of amine, 30 parts of earthworm extract；The Whitening, spot plant composition being prepared weighs 21 parts by weight.
The Whitening, spot plant composition the preparation method comprises the following steps:
(1) take it is dry take glycyrrhiza glabra, be crushed to 70 mesh, the ethanol water that 8 times of mass fractions are 75% be added, reflux mentions
2h is taken, is filtered, filter residue is repeated 3 times using same method, merging filtrate, rotary evaporation to paste, and distilled water is added extremely
Dipped lotion, stands overnight, and centrifugation discards supernatant liquid, collects sediment and is dried, obtains glabridin crude extract；
(2) glabridin crude extract is purified using macroreticular resin, macroreticular resin is first successively used to the 5% of 4 times of volumes
NaOH solution, the distilled water of 1.5 times of volumes, 3 times of volumes 10% hydrochloric acid washed, be then washed with distilled water to neutrality；It will
Macroreticular resin is totally immersed into 93% ethanol solution, filling into column, is stopped until the ethanol solution of outflow is without white opacity
It is filling, then ethanol solution is washed away with distilled water；Glabridin crude extract and dehydrated alcohol 1:12 in mass ratio are dissolved, note
Enter in macroporous resin column, resin column diameter height ratio 1:8, adsorption flow rate 2BV/h, 2 times of column volumes of applied sample amount, with the water of 3 times of column volumes
Elution, discards aqueous, then uses 70% ethanol elution of 6 times of column volumes, collects 70% ethanol eluate merging fraction, evaporates ethyl alcohol,
Up to glabridin extracting solution；
(3) earthworm leaf is taken, it is dry to constant weight, it smashes, is microwave irradiation effect in 1g:25 mL addition distilled water by solid-liquid ratio
7min, microwave power 250W；Leaching liquor carries out steam distillation, collects distillate, the quality to the distillate is described
Stop distillation at 4 times of material quality, the distillate is filtered after cooling 6 h at 4 DEG C, obtains earthworm extract；
(4) Vitamin C glycosides and niacinamide are mixed evenly with obtained glabridin extracting solution, earthworm extract,
Obtain Whitening, spot plant composition.
The essence cream the preparation method comprises the following steps:
S1. weight powder raw material is weighed；
S2. by methyl hydroxybenzoate, nard, propylene glycol, caprylic/capric triglyceride, butanediol, tripeptides -1, Sodium Hyaluronate, sea
Algae sugar, water, Whitening, spot plant composition are uniformly mixed, and are heated to 63 DEG C, are kept the temperature 1.2 h, are obtained mixture 1；
S3. xanthan gum, glycerin monostearate, methyl p-hydroxybenzoate, isohexadecane, ethoxy urea are uniformly mixed, are added
Heat keeps the temperature 0.8 h, obtains mixture 2 to 73 DEG C；
S4. mixture 1 is cooled to 25 DEG C, mixture 2 is added and stirs, speed of agitator 2500r/min, mixing time 1
The essence cream is made in h.
A kind of essence cream of the plant composition containing Whitening, spot of embodiment 2
Composition of raw materials is same as Example 1.
The composition of the Whitening, spot plant composition is same as Example 1.
The preparation method of the Whitening, spot plant composition is same as Example 1.
The essence cream the preparation method comprises the following steps:
S1. weight powder raw material is weighed；
S2. by methyl hydroxybenzoate, nard, propylene glycol, caprylic/capric triglyceride, butanediol, tripeptides -1, Sodium Hyaluronate, sea
Algae sugar, water, Whitening, spot plant composition are uniformly mixed, and are heated to 60 DEG C, are kept the temperature 1 h, are obtained mixture 1；
S3. xanthan gum, glycerin monostearate, methyl p-hydroxybenzoate, isohexadecane, ethoxy urea are uniformly mixed, are added
Heat obtains mixture 2 to 65 DEG C, 0.5 h of heat preservation；
S4. mixture 1 is cooled to 20 DEG C, mixture 2 is added and stirs, speed of agitator 2000r/min, mixing time 0.5
H obtains the essence cream.
A kind of essence cream of the plant composition containing Whitening, spot of embodiment 3
Composition of raw materials is same as Example 1.
The composition of the Whitening, spot plant composition is same as Example 1.
The preparation method of the Whitening, spot plant composition is same as Example 1.
The essence cream the preparation method comprises the following steps:
S1. weight powder raw material is weighed；
S2. by methyl hydroxybenzoate, nard, propylene glycol, caprylic/capric triglyceride, butanediol, tripeptides -1, Sodium Hyaluronate, sea
Algae sugar, water, Whitening, spot plant composition are uniformly mixed, and are heated to 65 DEG C, are kept the temperature 1.5h, are obtained mixture 1；
S3. xanthan gum, glycerin monostearate, methyl p-hydroxybenzoate, isohexadecane, ethoxy urea are uniformly mixed, are added
Heat obtains mixture 2 to 75 DEG C, 1 h of heat preservation；
S4. mixture 1 is cooled to 30 DEG C, mixture 2 is added and stirs, speed of agitator 3000r/min, mixing time 1h,
Obtain the essence cream.
A kind of essence cream of the plant composition containing Whitening, spot of embodiment 4
Composition of raw materials the difference from embodiment 1 is that, the additive amount of Whitening, spot plant composition is 18 parts by weight, remaining group
Divide and content is identical.
The composition of the Whitening, spot plant composition: 50 parts of glabridin extracting solution, 45 parts of Vitamin C glycosides, nicotinoyl
40 parts of amine, 30 parts of earthworm extract；The Whitening, spot plant composition being prepared weighs 18 parts by weight.
The preparation method of the Whitening, spot plant composition is same as Example 1.
The preparation method of the essence cream is same as Example 1.
A kind of essence cream of the plant composition containing Whitening, spot of embodiment 5
Composition of raw materials the difference from embodiment 1 is that, the additive amount of Whitening, spot plant composition is 24 parts by weight, remaining group
Divide and content is identical.
The composition of the Whitening, spot plant composition: 50 parts of glabridin extracting solution, 45 parts of Vitamin C glycosides, nicotinoyl
40 parts of amine, 30 parts of earthworm extract；The Whitening, spot plant composition being prepared weighs 24 parts by weight.
The preparation method of the Whitening, spot plant composition is same as Example 1.
The preparation method of the essence cream is same as Example 1.
A kind of essence cream of the plant composition containing Whitening, spot of embodiment 6
Composition of raw materials is identical as the parts by weight content of embodiment 1；Difference is that the group of the Whitening, spot plant composition becomes
10 parts of glabridin extracting solution, 10 parts of Vitamin C glycosides, 20 parts of niacinamide, 10 parts of earthworm extract, the whitening being prepared
Light spot plant composition weighs 21 parts.
The preparation method of the Whitening, spot plant composition is same as Example 1.
The preparation method of the essence cream is same as Example 1.
A kind of essence cream of the plant composition containing Whitening, spot of embodiment 7
Composition of raw materials is identical as the parts by weight content of embodiment 1；Difference is that the group of the Whitening, spot plant composition becomes
100 parts of glabridin extracting solution, 80 parts of Vitamin C glycosides, 60 parts of niacinamide, 50 parts of earthworm extract, the beauty being prepared
White light spot plant composition weighs 21 parts.
The preparation method of the Whitening, spot plant composition is same as Example 1.
The preparation method of the essence cream is same as Example 1.
Comparative example 1
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is the composition of the Whitening, spot plant composition only
There is glabridin extracting solution.
The preparation method of the essence cream is same as Example 1.
Comparative example 2
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is the composition of the Whitening, spot plant composition only
There is Vitamin C glycosides.
The preparation method of the essence cream is same as Example 1.
Comparative example 3
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is the composition of the Whitening, spot plant composition only
There is niacinamide.
The preparation method of the essence cream is same as Example 1.
Comparative example 4
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is the composition of the Whitening, spot plant composition only
There is earthworm extract.
Comparative example 5
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is that the group of the Whitening, spot plant composition becomes
90 parts of glabridin extracting solution, 75 parts of Vitamin C glycosides；Plant composition obtained weighs 21 parts.
The preparation method of the essence cream is same as Example 1.
Comparative example 6
Composition of raw materials is identical as the parts by weight content of embodiment 1；Difference is that the group of the Whitening, spot plant composition becomes
90 parts of glabridin extracting solution, 75 parts of niacinamide；Plant composition obtained weighs 21 parts.
The preparation method of the essence cream is same as Example 1.
Comparative example 7
Composition of raw materials is identical as the parts by weight content of embodiment 1；Difference is that the group of the Whitening, spot plant composition becomes
85 parts of Vitamin C glycosides, 80 parts of niacinamide weigh 21 parts after being uniformly mixed obtained plant composition.
The preparation method of the essence cream is same as Example 1.
Comparative example 8
Composition of raw materials is identical as the parts by weight content of embodiment 1；Difference is that the group of the Whitening, spot plant composition becomes
85 parts of glabridin extracting solution, 80 parts of earthworm extract weigh 21 parts after being uniformly mixed obtained plant composition.
The preparation method of the essence cream is same as Example 1.
Comparative example 9
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is that the group of the Whitening, spot plant composition becomes
80 parts of Vitamin C glycosides, 85 parts of earthworm extract weigh 21 parts after being uniformly mixed obtained plant composition.
The preparation method of the essence cream is same as Example 1.
Comparative example 10
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is that the group of the Whitening, spot plant composition becomes
85 parts of niacinamide, 80 parts of earthworm extract weigh 21 parts after being uniformly mixed obtained plant composition.
The preparation method of the essence cream is same as Example 1.
Comparative example 11
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is that the group of the Whitening, spot plant composition becomes
85 parts of glabridin extracting solution, 40 parts of Vitamin C glycosides, 40 parts of niacinamide weigh 21 after being uniformly mixed obtained plant composition
Part.
The preparation method of the essence cream is same as Example 1.
Comparative example 12
Composition of raw materials is identical as the parts by weight content of embodiment 1；Difference is that the group of the Whitening, spot plant composition becomes
85 parts of Vitamin C glycosides, 40 parts of niacinamide, 40 parts of earthworm extract weigh 21 parts after being uniformly mixed obtained plant composition.
The preparation method of the essence cream is same as Example 1.
Comparative example 13
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is that the group of the Whitening, spot plant composition becomes
85 parts of glabridin extracting solution, 40 parts of Vitamin C glycosides, 40 parts of earthworm extract, after being uniformly mixed obtained plant composition
Weigh 21 parts.
The preparation method of the essence cream is same as Example 1.
Comparative example 14
Composition of raw materials is identical as the parts by weight content of embodiment 1, and difference is that the group of the Whitening, spot plant composition becomes
85 parts of glabridin extracting solution, 40 parts of niacinamide, 40 parts of earthworm extract weigh 21 after being uniformly mixed obtained plant composition
Part.
The preparation method of the essence cream is same as Example 1.
Comparative example 15
Composition of raw materials the difference from embodiment 1 is that, the plant composition is not added in essence cream raw material.
The preparation method of the essence cream is same as Example 1.
Comparative example 16
The Whitening, spot essence cream of certain commercially available brand.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Effect test:
Skin brightness experiment:
Adult female (30-49 years old) is randomly divided into 23 groups, every group of 10 people, health, no skin disease and allergy medical history are non-quick
Feel skin, use the essence cream of embodiment 1 ~ 7 and comparative example 1 ~ 16 respectively, uses 2 times respectively for each person every day, be using the time
2 months, measure the variation of skin brightness.
With the brightness of skin measurement system (VISIA) measurement skin.Skin measurement system (VISIA-CR) is for evaluating
The brightness of skin.The same area of measured is detected at the 0th week and the 8th week with VISIA.Test position is entire face,
It takes pictures to face, and is analyzed with specialized image analysis is soft, (skin brightness measures 3 times, takes it flat for measurement facial skin brightness
Mean value is as skin brightness reference data), thus calculate skin brightness change rate (skin brightness change rate=(test preceding skin
Skin brightness after brightness-test)/test preceding skin brightness).The skin the bright, is worth higher, and the skin the dim, is worth lower.
Concrete outcome is as shown in table 1.
Influence of 1 essence cream of table to skin brightness
| Group | 0 week | 8 weeks | Changing value | Change rate (%) |
| Embodiment 1 | 62.30 | 73.78 | 11.48 | 18.43 |
| Embodiment 2 | 61.97 | 70.45 | 8.48 | 13.68 |
| Embodiment 3 | 62.18 | 71.43 | 9.25 | 14.87 |
| Embodiment 4 | 63.13 | 70.13 | 7.00 | 11.08 |
| Embodiment 5 | 61.81 | 68.24 | 6.43 | 10.40 |
| Embodiment 6 | 61.40 | 68.48 | 7.08 | 11.53 |
| Embodiment 7 | 62.05 | 69.25 | 7.20 | 11.60 |
| Comparative example 1 | 63.03 | 64.55 | 1.52 | 2.41 |
| Comparative example 2 | 61.87 | 62.86 | 0.99 | 1.61 |
| Comparative example 3 | 62.80 | 64.54 | 1.74 | 2.77 |
| Comparative example 4 | 62.10 | 63.78 | 1.68 | 2.70 |
| Comparative example 5 | 62.40 | 65.73 | 3.33 | 5.33 |
| Comparative example 6 | 61.84 | 65.27 | 3.43 | 5.54 |
| Comparative example 7 | 63.15 | 66.16 | 3.01 | 4.76 |
| Comparative example 8 | 61.55 | 64.87 | 3.32 | 5.39 |
| Comparative example 9 | 61.09 | 64.69 | 3.60 | 5.89 |
| Comparative example 10 | 62.14 | 65.04 | 2.90 | 4.66 |
| Comparative example 11 | 62.10 | 66.87 | 4.77 | 7.68 |
| Comparative example 12 | 61.86 | 66.64 | 4.78 | 7.72 |
| Comparative example 13 | 62.46 | 67.48 | 5.02 | 8.03 |
| Comparative example 14 | 62.17 | 66.88 | 4.71 | 7.57 |
| Comparative example 15 | 61.24 | 61.35 | 0.11 | 0.18 |
| Comparative example 16 | 61.84 | 66.34 | 4.50 | 7.27 |
Above data proves that the essence cream of present invention plant composition containing Whitening, spot can effectively improve skin brightness after use,
The skin brightness value of essence cream described in embodiment 1 can promote 18.43%, be significantly better than the Whitening, spot essence cream of comparative example 1 ~ 16.
Light spot effect test:
The light spot effect of essence cream obtained by the various embodiments described above 1 ~ 7 and comparative example 1 ~ 16 is evaluated by comparative analysis.
Test object: above-mentioned each group is female middle-aged, every group of 20 people, and 30 ~ 40 years old, health, no skin disease and mistake
Quick medical history, non-sensitive skin can be by Normalization rule cosmetics, and cooperating personnel complete appraisal as required, have
Certain expressive faculty, the impression after energy actual response use；
Test equipment: VISA digital skin analyzer (U.S.), Mexameter MX18 (CK Electronic GmbH, moral
State)；Test zone: cheek region (avoids laugh line, retroreflective regions, black mole and hair) as far as possible；Application method: morning and evening each 1 daily
It is secondary, persistently use 8 weeks；
Test analysis: by comparison using preceding and comparison diagram using color spot after 8 weeks and after deactivating 8 weeks, evaluation experimental group and right
According to the light spot effect of facial mask is organized, every group of average color spot reduced rate, and efficient (effective percentage=each group skin improvement people are found out
Number/each group total number of persons).Concrete outcome is as shown in table 3.
Influence of 2 essence cream of table to the light spot effect of skin
Above data proves, the essence cream of present invention plant composition containing Whitening, spot, using rear color spot reduced rate reach 90% with
On, effective percentage reaches 95% or more, is significantly better than the Whitening, spot facial mask of comparative example 1 ~ 16, and do not rebound after deactivating.
Whitening effect experiment:
Using double-blind study test evaluation whitening effect of the invention: in accordance with the above-mentioned embodiment 1 ~ 7 and comparative example 1 ~ 16 prepare essence
For magnificent frost product as sample to be tested, every group is selected 20 people at random, select the region human face 3cm × 3cm of skin health as by
Position is tried, subject smears each sample once in the morning and once at night daily, and it is continuous to smear 45 days, Lab colorimeter system spectral light is used weekly
The variation of degree meter (Minolta spectrophotometer CM-2002) measurement skin color.In Lab colorimeter system, with coordinate L, a, b it
Poor Δ L, Δ a, Δ b indicate the color difference Δ Eab between two kinds of stimulations, the i.e. distance between 2 color point of the colour space.
Δ Eab=[(Δ L) 2+ (Δ a) 2+ (Δ b) 2] 1/2.In formula: since Δ Eab is the composite index of L, a, b, generation
The three-dimensional variation of table coloration seeks the average value of every group of Δ Eab so being the appropriate index for evaluating colour of skin variation, specific to tie
Fruit is as shown in table 3.
Influence of 3 essence cream of table to skin whitening effects
The above result shows that the whitening effect of the essence cream of present invention plant composition containing Whitening, spot be significantly better than comparative example 1 ~
16 whitening effect is especially best with embodiment 1.
Claims (10)
1. a kind of plant composition with Whitening, spot effect, which is characterized in that the Whitening, spot plant composition, packet
It is prepared containing following raw material: 10 ~ 100 parts of glabridin extracting solution, 10 ~ 80 parts of Vitamin C glycosides, niacinamide 20 ~
60 parts.
2. the plant composition according to claim 1 with Whitening, spot effect, which is characterized in that the whitening is light
Spot plant composition is prepared comprising following raw material: 20 ~ 80 parts of glabridin extracting solution, Vitamin C glycosides 30 ~
70 parts, 30 ~ 50 parts of niacinamide.
3. the plant composition according to claim 1 with Whitening, spot effect, which is characterized in that the whitening is light
Spot plant composition is prepared comprising following raw material: 50 parts of glabridin extracting solution, 45 parts of Vitamin C glycosides, cigarette
40 parts of amide.
4. the plant composition according to claim 1 with Whitening, spot effect, which is characterized in that described has beauty
The plant composition of white light spot effect also includes 10 ~ 50 parts by weight of earthworm extract.
5. the plant composition according to claim 1 with Whitening, spot effect, which is characterized in that the light Radix Glycyrrhizae
Determine extracting solution the preparation method comprises the following steps:
(1) take it is dry take glycyrrhiza glabra, be crushed to 60 ~ 80 mesh, be added ethanol water, refluxing extraction, filtering, filter residue uses
Same method is repeated operation, merging filtrate, rotary evaporation to paste, and addition distilled water to dipped lotion is stood overnight,
Centrifugation discards supernatant liquid, collects sediment and is dried, obtains glabridin crude extract；
(2) glabridin crude extract is purified using macroreticular resin, macroreticular resin is first successively used to the 5% of 3 ~ 4 times of volumes
NaOH solution, the distilled water of 1 ~ 1.5 times of volume, 2 ~ 3 times of volumes 10 ~ 20% hydrochloric acid washed, be then washed with distilled water to
It is neutral；Macroreticular resin is totally immersed into 90 ~ 95% ethanol solution, it is filling into column, until the ethanol solution of outflow is without white
Stop filling when muddy, then washes away ethanol solution with distilled water；In mass ratio by glabridin crude extract and dehydrated alcohol
1:10 ~ 15 dissolves, and injects in macroporous resin column, resin column diameter height ratio 1:6 ~ 10,1 ~ 3BV/h of adsorption flow rate, 2 times of cylinders of applied sample amount
Product discards aqueous with the water elution of 2 ~ 3 times of column volumes, then with 70 ~ 80% ethanol elutions of 5-6 times of column volume, collects 70-80%
Ethanol eluate merges fraction, evaporates ethyl alcohol to get glabridin extracting solution.
6. the preparation method of glabridin extracting solution according to claim 5, which is characterized in that step (1) is described added
Ethanol water mass fraction is 50 ~ 100%, and additional amount is 5 ~ 10 times of glycyrrhiza glabra quality；Return time is 1.5 ~ 2.5h；
Number of operations is 2 ~ 4 times repeatedly.
7. Whitening, spot plant composition according to claim 1, which is characterized in that the system of the earthworm extract
Preparation Method are as follows:
Earthworm leaf is taken, it is dry to constant weight, it smashes, is added in distilled water by solid-liquid ratio, microwave irradiation effect；Leaching liquor carries out water
Distillate is collected in steam distillation, after stopping distillation, by the distillate cooled and filtered, obtains earthworm extract.
8. the preparation method of earthworm extract according to claim 7, which is characterized in that the earthworm extract
Preparation condition is that solid-liquid ratio is the mL of 1g:20 ~ 30；6 ~ 8min of microwave irradiation effect, microwave power are 220 ~ 280W；The stopping
Distillation condition is 3 ~ 6 times that the quality of distillate is the material quality；Distillate cooling temperature is 2 ~ 5 DEG C, cooling time 5
~7 h。
9. the plant composition according to claim 1 with Whitening, spot effect, which is characterized in that the whitening is light
The plant composition of spot the preparation method comprises the following steps:
First glabridin extracting solution is heated, the mixing of earthworm extract is added, continues heat temperature raising, vitamin is added again
C glucosides and niacinamide, stirring, obtain Whitening, spot plant composition.
10. the preparation method of Whitening, spot plant composition according to claim 9, which is characterized in that the light is sweet
Grass determine extracting solution and is heated to 50 ~ 55 DEG C, and earthworm extract is added and is mixed and heated to 65 ~ 75 DEG C, the mixing speed for 1000 ~
1200 r/min, mixing time are 20 ~ 35min.
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| CN114699345A (en) * | 2021-09-18 | 2022-07-05 | 广东汉氏干细胞生物科技有限公司 | Application of plant extract in whitening and spot-fading cosmetics and preparation method thereof |
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Effective date of registration: 20230518 Address after: Room 301 and Room 401, Building 2, No. 17, Resuscitation Jinhe 1st Road, Panyu District, Guangzhou City, Guangdong Province, 510663 Patentee after: Guangzhou yanduo cosmetics technology Co.,Ltd. Address before: 510000 Room 201, building 19, Tian'an headquarters center, No. 555, North Panyu Avenue, Donghuan street, Panyu District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU AIBAIYI BIOLOGY TECHNOLOGY CO.,LTD. |