CN109620782B - Plant composition with whitening and spot-fading effects - Google Patents
Plant composition with whitening and spot-fading effects Download PDFInfo
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- CN109620782B CN109620782B CN201811302609.9A CN201811302609A CN109620782B CN 109620782 B CN109620782 B CN 109620782B CN 201811302609 A CN201811302609 A CN 201811302609A CN 109620782 B CN109620782 B CN 109620782B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention relates to the technical field of cosmetics, in particular to a plant composition with whitening and spot-fading effects, which comprises the following raw materials in parts by weight: 10-100 parts of glabridin extract, 10-80 parts of vitamin C glucoside and 20-60 parts of nicotinamide. The whitening and spot-removing plant composition disclosed by the invention has the advantages that through reasonable proportioning, the components of the whitening and spot-removing plant composition generate a synergistic effect, the defects of the whitening and spot-removing plant composition when the whitening and spot-removing plant composition is used independently are overcome, and compared with a whitening skin care product only containing a single active component or double-active or triple-active components, the whitening and spot-removing efficacy of the product containing the plant composition is more comprehensive and efficient.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a plant composition with whitening and spot-fading effects and a preparation method thereof.
Background
The pigmented spots are skin pigmentation and belong to pigmentation disorder dermatosis. The formation of the color spot is caused by various reasons, such as ultraviolet irradiation, genetic factors, drug factors, pregnancy and the like, which cause the increase of skin pigment and the failure of timely metabolism, thereby leading to the pigmentation and the uneven distribution. Melanin is a biological pigment, which is present in the middle of the cells in the basal layer of the skin. When the pigment mother cells are stimulated by ultraviolet rays and the like, the skin is in a self-protection state, the pigment mother cells accelerate the secretion of Mailanin pigment, and the activity of tyrosinase is activated to protect the skin cells. Usually, melanin precursor dopa is oxidized by tyrosine to release melanin, and then moves layer by layer through cell metabolism to the skin epidermis to form freckles, sunburn, dark spots, and the like. Therefore, when the whitening and spot-lightening treatment is carried out, the generation and the activity of tyrosinase can be inhibited, so that the formation of melanin can be inhibited. In addition, the effective control of the melanin pigmentation in the skin can be realized through the modes of melanin reduction, melanin metabolism promotion, ultraviolet ray prevention and the like, so that the effects of whitening and spot lightening are realized.
At present, the treatment method can remove spots through laser, although the spot removing effect is quick, a patient needs to bear stabbing pain and is easy to relapse, so the treatment method is not the optimal treatment method for the patient, corrosive medicines or decolouring ointment can be used for coating the affected part to promote the skin lesion to have spots and fall off, and traditional Chinese medicines are used for being matched with the whole body treatment through nourishing yin and tonifying kidney, soothing liver and regulating qi, neutralizing qi and blood and the like. However, the methods do not cause great damage to skin, the traditional Chinese medicine conditioning and decoction time is long, the preparation is troublesome and difficult to persist, and therefore the ideal effects of removing freckles and whitening are not achieved.
Therefore, whitening skin care has attracted much attention at home and abroad, and whitening skin care products are also in endlessly. In order to achieve the whitening effect, some whitening products use lead, mercury and other chemicals harmful to human bodies to promote tyrosinase to be inactivated, and although the method can achieve the effects of reducing melanin deposition in a short time and achieving quick whitening and spot lightening, all enzymes of the skin are inactivated, even cells are dead, and meanwhile, hidden troubles are brought to health. Therefore, effective and safe whitening and freckle removing products are favored by people.
Disclosure of Invention
The invention aims to solve the technical problem of providing a whitening and freckle-removing plant composition with excellent whitening and freckle-removing effects and good use safety and a preparation method thereof.
The invention provides a whitening and spot-fading plant composition, which is realized by the following technical scheme:
a plant composition with whitening and spot-fading effects comprises the following raw materials in parts by weight: 10-100 parts of glabridin extract, 10-80 parts of vitamin C glucoside and 20-60 parts of nicotinamide.
As a preferable scheme, the whitening and spot-lightening plant composition is prepared from the following raw materials in parts by weight: 20-80 parts of glabridin extract, 30-70 parts of vitamin C glucoside and 30-50 parts of nicotinamide.
As an optimal scheme, the whitening and spot-fading plant composition is prepared from the following raw materials in parts by weight: 50 parts of glabridin extract, 45 parts of vitamin C glucoside and 40 parts of nicotinamide.
Preferably, the plant composition with the effects of whitening and fading spots further comprises 10-50 parts by weight of the extract of dioscorea nipponica.
As a preferred scheme, the preparation method of the glabridin extract comprises the following steps:
(1) taking dried glabridin, crushing to 60-80 meshes, adding an ethanol water solution, carrying out reflux extraction, filtering, repeatedly carrying out operation on filter residues by the same method, combining filter liquor, carrying out rotary evaporation to obtain a paste, adding distilled water to soak the paste, standing overnight, centrifuging to remove a supernatant, collecting a precipitate, and drying to obtain a glabridin crude extract;
(2) purifying the glabridin crude extract by adopting macroporous resin, washing the macroporous resin with 3-4 times of 5% NaOH solution, 1-1.5 times of distilled water and 2-3 times of 10-20% hydrochloric acid in sequence, and then washing the macroporous resin with the distilled water to be neutral; completely soaking the macroporous resin in 90-95% ethanol solution, filling the column, stopping filling until the effluent ethanol solution is white and turbid, and then washing the ethanol solution by using distilled water; mixing the glabridin crude extract and absolute ethyl alcohol according to a mass ratio of 1: 10-15, dissolving, and injecting into a macroporous resin column, wherein the height ratio of the resin column diameter to the height is 1: 6-10, the adsorption flow rate is 1-3 BV/h, the sample loading amount is 2 times of the column volume, water with the column volume being 2-3 times of the column volume is used for elution, water liquid is discarded, 70-80% ethanol with the column volume being 5-6 times of the column volume is used for elution, 70-80% ethanol eluent is collected and fractions are combined, and ethanol is evaporated, so that glabridin extract is obtained.
As a preferable scheme, the mass fraction of the ethanol aqueous solution added in the step (1) is 50-100%, and the addition amount is 5-10 times of the mass of the glycyrrhiza glabra; the reflux time is 1.5-2.5 h; the number of repeated operations is 2-4.
As a preferred scheme, the preparation method of the dioscorea nipponica extract comprises the following steps:
drying folium Pheretima, pulverizing, adding into distilled water, and microwave-radiating; steam distilling the leaching liquor, collecting distillate, cooling the distillate after stopping distillation, and filtering to obtain rhizoma Dioscoreae Zingiberensis extract.
As a preferable scheme, the preparation condition of the dioscorea nipponica extract is that the ratio of material to liquid is 1g: 20-30 mL; performing microwave radiation for 6-8 min, wherein the microwave power is 220-280W; the distillation stopping condition is that the mass of the distillate is 3-6 times of that of the raw materials; the cooling temperature of the distillate is 2-5 ℃, and the cooling time is 5-7 h.
As a preferable scheme, the preparation method of the plant composition for whitening and lightening spots comprises the following steps:
heating the glabridin extract, adding the earthworm extract, continuously heating, adding the vitamin C glucoside and the nicotinamide again, and stirring to obtain the whitening and spot-fading plant composition.
Preferably, the glabridin extract is heated to 50-55 ℃, the earthworm extract is added to be mixed and heated to 65-75 ℃, the stirring speed is 1000-1200 r/min, and the stirring time is 20-35 min.
Has the advantages that: the whitening and freckle-removing plant composition is prepared from glabridin extract, vitamin C glucoside, nicotinamide and rhizoma dioscoreae nipponicae extract according to a reasonable proportion, 4 components supplement each other and generate a synergistic effect on the whitening and freckle-removing effects of the plant composition, so that the whitening and freckle-removing effects of the skin care product can be greatly improved, the defects of the skin care product when the skin care product is used independently are overcome, compared with a whitening product only containing a single active component or double-active or three active components, the whitening and freckle-removing effects of the product containing the plant composition are more comprehensive and efficient, the plant composition can be used as a functional additive to be added into various whitening and freckle-removing products to form cosmetics in different formulations with excellent whitening and freckle-removing effects, and the application is wide. In addition, the plant composition has high safety, no adverse reaction and good stability, and makes up for the obvious defect of insufficient functions of commercially available skin care products.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer and more complete, the technical solutions of the embodiments of the present invention will be described below, and the present invention will be further described with reference to specific embodiments by taking the above plant composition for whitening and spot-lightening as a functional additive to prepare an essence cream containing the plant composition for whitening and spot-lightening.
However, the whitening and spot-fading plant composition can be added into whitening skin care products in different formulations such as aqua, emulsion, cream, essence, facial mask and the like. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1 essence cream containing whitening and spot-lightening plant composition
The raw material formula is as follows: 1.8 parts of methylparaben, 1 part of xanthan gum, 4.5 parts of nard, 6.5 parts of glycerin monostearate, 2 parts of propylene glycol, 0.6 part of methyl p-hydroxybenzoate, 3.5 parts of caprylic/capric triglyceride, 1.2 parts of isohexadecane, 5 parts of butanediol, 4 parts of hydroxyethyl urea, 11.8 parts of tripeptide, 1.3 parts of sodium hyaluronate, 1.4 parts of trehalose, 60 parts of water and 21 parts of a whitening and spot-lightening plant composition.
The whitening and spot-fading plant composition comprises the following components: 50 parts of glabridin extract, 45 parts of vitamin C glucoside, 40 parts of nicotinamide and 30 parts of rhizoma dioscoreae nipponicae extract; 21 parts by weight of the prepared whitening and spot-lightening plant composition is weighed.
The preparation method of the whitening and spot-fading plant composition comprises the following steps:
(1) pulverizing dried Glycyrrhiza glabra Linne to 70 mesh, adding 75% ethanol water solution 8 times of the weight percentage, reflux extracting for 2h, filtering, repeatedly extracting the residue for 3 times by the same method, mixing filtrates, rotary evaporating to paste, adding distilled water to soak the paste, standing overnight, centrifuging to remove supernatant, collecting precipitate, and drying to obtain crude extract of glabridin;
(2) purifying the crude glabridin extract by using macroporous resin, washing the macroporous resin with 4 times of 5% NaOH solution, 1.5 times of distilled water and 3 times of 10% hydrochloric acid in sequence, and then washing the macroporous resin with the distilled water to be neutral; completely soaking the macroporous resin in 93% ethanol solution, filling into the column, stopping filling until the effluent ethanol solution is white and turbid, and then washing the ethanol solution with distilled water; mixing the glabridin crude extract and absolute ethyl alcohol according to a mass ratio of 1: 12, dissolving, and injecting into a macroporous resin column, wherein the height ratio of the resin column diameter to the resin column diameter is 1: 8, adsorbing at the flow rate of 2BV/h, eluting with water 3 times the column volume, discarding water solution, eluting with 70% ethanol 6 times the column volume, collecting 70% ethanol eluate, mixing fractions, and evaporating ethanol to obtain glabridin extract;
(3) drying the leaves of the common andrographis herb to constant weight, crushing, adding the dried leaves of the common andrographis herb to distilled water according to the material-liquid ratio of 1g to 25 mL, and performing microwave radiation for 7min at the microwave power of 250W; performing steam distillation on the leaching liquor, collecting distillate, stopping distillation when the mass of the distillate is 4 times of that of the raw materials, cooling the distillate at 4 ℃ for 6 h, and filtering to obtain the extract of the dioscorea nipponica;
(4) mixing vitamin C glycoside and nicotinamide with the obtained glabridin extract and Pheretima aspergillum extract, and stirring to obtain the plant composition with skin whitening and speckle reducing effects.
The preparation method of the essence cream comprises the following steps:
s1, weighing powder raw materials;
s2, uniformly mixing methyl hydroxybenzoate, nardostachys chinensis, propylene glycol, caprylic/capric triglyceride, butanediol, tripeptide-1, sodium hyaluronate, trehalose, water and the whitening and spot-fading plant composition, heating to 63 ℃, and preserving heat for 1.2 hours to obtain a mixture 1;
s3, uniformly mixing xanthan gum, glyceryl monostearate, methyl p-hydroxybenzoate, isohexadecane and hydroxyethyl urea, heating to 73 ℃, and keeping the temperature for 0.8 h to obtain a mixture 2;
and S4, cooling the mixture 1 to 25 ℃, adding the mixture 2, and stirring at the stirring speed of 2500r/min for 1h to obtain the essence cream.
Example 2 essence cream containing whitening and spot-lightening plant composition
The raw material formulation was the same as in example 1.
The composition of the plant composition for whitening and lightening spots is the same as that of the example 1.
The preparation method of the plant composition for whitening and lightening spots is the same as that of the embodiment 1.
The preparation method of the essence cream comprises the following steps:
s1, weighing powder raw materials;
s2, uniformly mixing methyl hydroxybenzoate, nardostachys chinensis, propylene glycol, caprylic/capric triglyceride, butanediol, tripeptide-1, sodium hyaluronate, trehalose, water and the whitening and spot-fading plant composition, heating to 60 ℃, and preserving heat for 1h to obtain a mixture 1;
s3, uniformly mixing xanthan gum, glyceryl monostearate, methyl p-hydroxybenzoate, isohexadecane and hydroxyethyl urea, heating to 65 ℃, and keeping the temperature for 0.5 h to obtain a mixture 2;
and S4, cooling the mixture 1 to 20 ℃, adding the mixture 2, and stirring at the stirring speed of 2000r/min for 0.5 h to obtain the essence cream.
Example 3 essence cream containing whitening and spot-lightening plant composition
The raw material formulation was the same as in example 1.
The composition of the plant composition for whitening and lightening spots is the same as that of the example 1.
The preparation method of the plant composition for whitening and lightening spots is the same as that of the embodiment 1.
The preparation method of the essence cream comprises the following steps:
s1, weighing powder raw materials;
s2, uniformly mixing methyl hydroxybenzoate, nardostachys chinensis, propylene glycol, caprylic/capric triglyceride, butanediol, tripeptide-1, sodium hyaluronate, trehalose, water and the whitening and spot-fading plant composition, heating to 65 ℃, and preserving heat for 1.5 hours to obtain a mixture 1;
s3, uniformly mixing xanthan gum, glyceryl monostearate, methyl p-hydroxybenzoate, isohexadecane and hydroxyethyl urea, heating to 75 ℃, and keeping the temperature for 1h to obtain a mixture 2;
and S4, cooling the mixture 1 to 30 ℃, adding the mixture 2, and stirring at the stirring speed of 3000r/min for 1h to obtain the essence cream.
Example 4 essence cream containing whitening and spot-lightening plant composition
The raw material formula is different from that of the example 1 in that the addition amount of the whitening and spot-fading plant composition is 18 parts by weight, and the rest components and the content are the same.
The whitening and spot-fading plant composition comprises the following components: 50 parts of glabridin extract, 45 parts of vitamin C glucoside, 40 parts of nicotinamide and 30 parts of rhizoma dioscoreae nipponicae extract; weighing 18 parts by weight of the prepared whitening and spot-fading plant composition.
The preparation method of the plant composition for whitening and lightening spots is the same as that of the embodiment 1.
The preparation method of the essence cream is the same as that of example 1.
Example 5 essence cream containing whitening and spot-lightening plant composition
The raw material formula is different from that of the example 1 in that the addition amount of the whitening and spot-fading plant composition is 24 parts by weight, and the rest components and the content are the same.
The whitening and spot-fading plant composition comprises the following components: 50 parts of glabridin extract, 45 parts of vitamin C glucoside, 40 parts of nicotinamide and 30 parts of rhizoma dioscoreae nipponicae extract; 24 parts by weight of the prepared whitening and spot-lightening plant composition is weighed.
The preparation method of the plant composition for whitening and lightening spots is the same as that of the embodiment 1.
The preparation method of the essence cream is the same as that of example 1.
Example 6 essence cream containing whitening and spot-lightening plant composition
The raw material formula and the content of the raw material formula are the same as the content of the raw material formula in the embodiment 1 in parts by weight; the whitening spot-lightening plant composition is characterized by comprising 10 parts of glabridin extract, 10 parts of vitamin C glucoside, 20 parts of nicotinamide and 10 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the prepared whitening spot-lightening plant composition is weighed.
The preparation method of the plant composition for whitening and lightening spots is the same as that of the embodiment 1.
The preparation method of the essence cream is the same as that of example 1.
Example 7 essence cream containing whitening and spot-lightening plant composition
The raw material formula and the content of the raw material formula are the same as the content of the raw material formula in the embodiment 1 in parts by weight; the whitening spot-lightening plant composition is characterized by comprising 100 parts of glabridin extract, 80 parts of vitamin C glucoside, 60 parts of nicotinamide and 50 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the prepared whitening spot-lightening plant composition is weighed.
The preparation method of the plant composition for whitening and lightening spots is the same as that of the embodiment 1.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 1
The raw material formula is the same as that of example 1 in parts by weight, except that the whitening and spot-fading plant composition only comprises glabridin extract.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 2
The raw material formula and the content of the raw material formula in the embodiment 1 are the same in parts by weight, except that the composition of the plant composition for whitening and lightening spots only comprises vitamin C glucoside.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 3
The raw material formula is the same as the content of the embodiment 1 in parts by weight, except that the composition of the plant composition for whitening and lightening spots only comprises nicotinamide.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 4
The raw material formula is the same as the content of the raw material formula in the embodiment 1 in parts by weight, except that the plant composition for whitening and lightening spots only comprises the extract of the dioscorea nipponica.
Comparative example 5
The raw material formula is the same as that of the embodiment 1 in parts by weight, and the difference is that the whitening and spot-fading plant composition comprises 90 parts of glabridin extract and 75 parts of vitamin C glucoside; 21 parts of the prepared plant composition are weighed.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 6
The raw material formula and the content of the raw material formula are the same as the content of the raw material formula in the embodiment 1 in parts by weight; the whitening spot-lightening plant composition is characterized by comprising 90 parts of glabridin extract and 75 parts of nicotinamide; 21 parts of the prepared plant composition are weighed.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 7
The raw material formula and the content of the raw material formula are the same as the content of the raw material formula in the embodiment 1 in parts by weight; the whitening spot-lightening plant composition is characterized by comprising 85 parts of vitamin C glucoside and 80 parts of nicotinamide, and 21 parts of the plant composition is weighed after the plant composition is prepared by uniformly mixing.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 8
The raw material formula and the content of the raw material formula are the same as the content of the raw material formula in the embodiment 1 in parts by weight; the difference is that the whitening and spot-fading plant composition comprises 85 parts of glabridin extract and 80 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the plant composition is weighed after the plant composition is prepared by uniformly mixing.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 9
The raw material formula is the same as that of the embodiment 1 in parts by weight, except that the whitening and spot-fading plant composition comprises 80 parts of vitamin C glucoside and 85 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the plant composition is weighed after the plant composition is uniformly mixed.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 10
The raw material formula is the same as the content of the raw material formula in the embodiment 1 in parts by weight, and the difference is that the whitening and spot-fading plant composition comprises 85 parts of nicotinamide and 80 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the plant composition is weighed after the plant composition is uniformly mixed.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 11
The raw material formula is the same as that of the embodiment 1 in parts by weight, and the difference is that the whitening and spot-fading plant composition comprises 85 parts of glabridin extract, 40 parts of vitamin C glucoside and 40 parts of nicotinamide, and 21 parts of the plant composition is weighed after the glabridin extract, the vitamin C glucoside and the nicotinamide are uniformly mixed to prepare the plant composition.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 12
The raw material formula and the content of the raw material formula are the same as the content of the raw material formula in the embodiment 1 in parts by weight; the difference is that the whitening spot-lightening plant composition comprises 85 parts of vitamin C glucoside, 40 parts of nicotinamide and 40 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the plant composition is weighed after the plant composition is prepared by uniformly mixing.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 13
The raw material formula is the same as the content of the raw material formula in example 1 in parts by weight, and the difference is that the whitening and spot-fading plant composition comprises 85 parts of glabridin extract, 40 parts of vitamin C glucoside and 40 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the plant composition is weighed after the plant composition is prepared by uniformly mixing the raw material formula and the components.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 14
The raw material formula is the same as the content of the raw material formula in the embodiment 1 in parts by weight, and the difference is that the whitening and spot-fading plant composition comprises 85 parts of glabridin extract, 40 parts of nicotinamide and 40 parts of rhizoma dioscoreae nipponicae extract, and 21 parts of the plant composition is weighed after the plant composition is prepared by uniformly mixing.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 15
The raw material formula is different from that of example 1 in that the plant composition is not added to the raw materials of the essence cream.
The preparation method of the essence cream is the same as that of example 1.
Comparative example 16
A certain brand of whitening and spot-lightening essence cream is sold in the market.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Effect test:
skin brightness test:
adult women (30-49 years old) were randomly divided into 23 groups of 10 persons each, healthy, without a history of skin disease and allergy, and non-sensitive skin, and the essence creams of examples 1-7 and comparative examples 1-16 were used, respectively, 2 times per day for 2 months, and the change in skin brightness was measured.
Skin radiance was measured with a skin test system (VISIA). The skin test system (VISIA-CR) was used to evaluate the radiance of the skin. The same part of the subject was examined at week 0 and week 8 using VISIA. The test part was the whole face, the face was photographed, and analyzed by professional image analysis software, and the skin brightness of the face was measured (skin brightness was measured 3 times, and the average value thereof was taken as skin brightness reference data), whereby the skin brightness change rate (skin brightness change rate — skin brightness after test)/skin brightness before test) was calculated. The brighter the skin the higher the value, and the darker the skin the lower the value. Specific results are shown in table 1.
TABLE 1 Effect of the essence on skin Brightness
The data prove that the essence cream containing the whitening and spot-fading plant composition can effectively improve the skin brightness after being used, and the skin brightness value of the essence cream in the embodiment 1 can be improved by 18.43%, so that the essence cream is obviously superior to the whitening and spot-fading essence creams in the comparative examples 1-16.
And (3) speckle fading effect test:
the spot-fading effect of the essence creams prepared in the above examples 1 to 7 and comparative examples 1 to 16 was evaluated by comparative analysis.
Test objects: the cosmetic is suitable for middle-aged women, each group is 20 women and 30-40 years old, is healthy, has no skin disease and allergic disease history, is non-sensitive skin, can use cosmetics according to the standard, is matched with workers to complete evaluation work according to requirements, has certain expression capability, and can truly reflect the feeling after use;
testing an instrument: VISA digital skin analyzer (USA), Mexameter MX18 (CK Electronic GmbH, Germany); test area: cheek area (avoid smiling lines, light reflecting areas, moles and hair as much as possible); the using method comprises the following steps: the preparation is administered 1 time each day in the morning and evening for 8 weeks;
and (3) testing and analyzing: the facial mask speckle-lightening effect of the experimental group and the control group is evaluated by comparing the color spots before use and after 8 weeks use and the comparison graph after 8 weeks of rest, and the average color spot reduction rate and the effective rate (effective rate is the number of skin improvement people of each group/the total number of people of each group) of each group are obtained. Specific results are shown in table 2.
TABLE 2 Effect of the essence cream on the skin Spot-lightening Effect
The data prove that the essence cream containing the whitening and spot-fading plant composition has the advantages that the reduction rate of color spots after the essence cream is used is more than 90%, the effective rate is more than 95%, the essence cream is obviously superior to the whitening and spot-fading facial masks in comparative examples 1-16, and the essence cream does not rebound after being stopped.
Whitening effect experiment:
the whitening effect of the invention is tested and evaluated by adopting a double-blind method: the essence cream products prepared according to the above examples 1-7 and comparative examples 1-16 are used as samples to be tested, 20 persons are randomly selected from each group, a 3CM × 3CM area of a healthy adult face is selected as a tested part, a subject applies each sample once every day in the morning and at the evening for 45 days continuously, and changes of skin colors are measured by using a Lab colorimetric system spectrophotometer (Meinenda spectrophotometer CM-2002) every week. In the Lab colorimetric system, the color difference Δ Eab between two stimuli, i.e. the distance between two color points in color space, is represented by the difference Δ L, Δ a, Δ b between the coordinates L, a, b.
TABLE 3 Effect of the essence cream on skin whitening Effect
The results show that the whitening effect of the essence cream containing the whitening and spot-fading plant composition is obviously superior to that of comparative examples 1-16, and especially the best whitening effect is obtained in example 1.
Claims (2)
1. The plant composition with the whitening and spot-fading effects is characterized by being prepared from the following raw materials in parts by weight: 10-100 parts of glabridin extract, 10-80 parts of vitamin C glucoside, 20-60 parts of nicotinamide and 10-50 parts of lumbricus extract;
the preparation method of the glabridin extract comprises the following steps: (1) taking dried glabridin, crushing to 60-80 meshes, adding an ethanol water solution, carrying out reflux extraction, filtering, repeatedly carrying out operation on filter residues by the same method, combining filter liquor, carrying out rotary evaporation to obtain a paste, adding distilled water to soak the paste, standing overnight, centrifuging to remove a supernatant, collecting a precipitate, and drying to obtain a glabridin crude extract; (2) purifying the glabridin crude extract by adopting macroporous resin, washing the macroporous resin with 3-4 times of 5% NaOH solution, 1-1.5 times of distilled water and 2-3 times of 10-20% hydrochloric acid in sequence, and then washing the macroporous resin with the distilled water to be neutral; completely soaking the macroporous resin in 90-95% ethanol solution, filling the column, stopping filling until the effluent ethanol solution is white and turbid, and then washing the ethanol solution by using distilled water; mixing the glabridin crude extract and absolute ethyl alcohol according to a mass ratio of 1: 10-15, dissolving, and injecting into a macroporous resin column, wherein the height ratio of the resin column diameter to the height is 1: 6-10, adsorbing at the flow rate of 1-3 BV/h, loading 2 times of column volume, eluting with 2-3 times of column volume of water, discarding water solution, eluting with 5-6 times of column volume of 70-80% ethanol, collecting 70-80% ethanol eluate, mixing fractions, and evaporating ethanol to obtain glabridin extract; wherein the mass fraction of the ethanol aqueous solution added in the step (1) is 50-100%, and the addition amount is 5-10 times of the mass of the glycyrrhiza glabra; the reflux time is 1.5-2.5 h; the repeated operation times are 2-4 times;
the preparation method of the dioscorea nipponica extract comprises the following steps: drying folium Pheretima, pulverizing, adding into distilled water, and microwave-radiating; steam distilling the leaching liquor, collecting distillate, cooling the distillate, and filtering to obtain Pheretima aspergillum extract;
the preparation condition of the dioscorea nipponica extract is that the ratio of material to liquid is 1g: 20-30 mL; performing microwave radiation for 6-8 min, wherein the microwave power is 220-280W; the distillation stopping condition is that the mass of the distillate is 3-6 times of that of the raw materials; cooling the distillate at the temperature of 2-5 ℃ for 5-7 h;
the preparation method of the plant composition for whitening and lightening the spots comprises the following steps: heating the glabridin extract, adding the earthworm extract, continuously heating, adding the vitamin C glucoside and the nicotinamide again, and stirring to obtain the whitening and spot-fading plant composition.
2. The method for preparing the plant composition for whitening and lightening spots according to claim 1, wherein the glabridin extract is heated to 50-55 ℃, the earthworm extract is added to be mixed and heated to 65-75 ℃, the stirring speed is 1000-1200 r/min, and the stirring time is 20-35 min.
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Effective date of registration: 20230518 Address after: Room 301 and Room 401, Building 2, No. 17, Resuscitation Jinhe 1st Road, Panyu District, Guangzhou City, Guangdong Province, 510663 Patentee after: Guangzhou yanduo cosmetics technology Co.,Ltd. Address before: 510000 Room 201, building 19, Tian'an headquarters center, No. 555, North Panyu Avenue, Donghuan street, Panyu District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU AIBAIYI BIOLOGY TECHNOLOGY CO.,LTD. |