CN104127331B - A kind of skin care product and its preparation method improving skin and resisting quick and repair ability - Google Patents
A kind of skin care product and its preparation method improving skin and resisting quick and repair ability Download PDFInfo
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- CN104127331B CN104127331B CN201410385639.6A CN201410385639A CN104127331B CN 104127331 B CN104127331 B CN 104127331B CN 201410385639 A CN201410385639 A CN 201410385639A CN 104127331 B CN104127331 B CN 104127331B
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- baicalin
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
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- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims abstract description 20
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- 239000004378 Glycyrrhizin Substances 0.000 claims abstract description 18
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 18
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 18
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 18
- 244000146462 Centella asiatica Species 0.000 claims abstract description 17
- 235000004032 Centella asiatica Nutrition 0.000 claims abstract description 17
- 229930182478 glucoside Natural products 0.000 claims abstract description 17
- 150000008131 glucosides Chemical class 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 239000008367 deionised water Substances 0.000 claims abstract description 14
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 14
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011187 glycerol Nutrition 0.000 claims abstract description 13
- 239000000047 product Substances 0.000 claims description 21
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
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- 239000003814 drug Substances 0.000 claims description 6
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
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Abstract
The present invention discloses a kind of skin that improves and resists skin care product that are quick and repair ability, is made up of following raw material: pachyman 30-90 part, glycerine 0.1-10 part, Trimethyl glycine 0.1-5 part, baicalin 0.01-3 part, glycyrrhizin 0.01-5 part, centella asiatica glucoside 0.01-5 part, deionized water 0-69.77 part. The present invention selects the pachyman of the amino acid humectant of natural structure and natural origin composite, not only can improve rapidly the water tariff collection power of skin, firmly pin moisture, activated cell vigor, skin can be improved again to the absorption of the natural anti-inflammatory activity compositions such as baicalin, glycyrrhizin, centella asiatica glucoside, thus playing anti-inflammatory anti-itch effect, it is to increase skin resists quick ability and repair ability; Formula is simple, and raw material almost all derives from plant constituent, avoids the stimulation of chemosynthesis composition, can effectively improve the symptoms such as redness that easy quick skin occurs, itch, decortication, allow the comfortable safety of skin feel lay equal stress on and newly set up skin barrier function; Its preparation technology is simple, and cost is lower.
Description
Technical field
The present invention relates to a kind of skin care product, it is specifically related to a kind of skin care product and its preparation method that improve skin and resist quick and repair ability.
Background technology
The human hair myogenic skin sensitivity phenomenon got more and more is caused due to factors such as the external environment influence such as atmospheric pollution or use makeup improper (comprising life-time service in poor quality cosmetic, containing hormones, antibiotics makeup etc.), show as skin thinner, more fragile, capillary vessel appears, skin is easily rubescent, time have the sensation scratched where it itches, also have little erythema occur. In existing market, major part skin care product ingredient is many and complicated, and overwhelming majority raw material is chemosynthesis source, generally all contain sanitas, essence, pigment etc., these compositions have increased the weight of skin burden, allow sensitive skin can't bear the heavy load especially, it is easy to that the symptoms such as redness, itch, decortication occur.
Therefore, for these responsive skin, research and develop a kind of skin that can improve and resist quick ability and repair ability, can effectively resist external stimulus, alleviate skin sensitivity, allow the comfortable safety of skin feel skin care product newly setting up skin barrier function of laying equal stress on seem particularly important.
Summary of the invention
It is an object of the invention to provide the skin care product that a kind of formula is relatively simple, raw material almost all derives from plant constituent, improve skin safely and effectively resists quick ability and repair ability.
Another object of the present invention is to provide the preparation method of the skin care product that above-mentioned raising skin resists quick and repair ability.
The present invention is achieved through the following technical solutions:
Improve skin and resist skin care product that are quick and repair ability, be made up of the raw material of following portions by weight:
Pachyman 30-90 part, glycerine 0.1-10 part, Trimethyl glycine 0.1-5 part, baicalin 0.01-3 part, glycyrrhizin 0.01-5 part, centella asiatica glucoside 0.01-5 part, deionized water 0-69.77 part.
Preferably, the weight part number of each raw material is:
Pachyman 80 parts, glycerine 5 parts, Trimethyl glycine 5 parts, baicalin 0.5 part, glycyrrhizin 0.5 part, centella asiatica glucoside 0.1 part, deionized water 8.9 parts.
Raising skin of the present invention resists the preparation method of the skin care product of quick and repair ability, comprises the following steps:
(1) extraction of pachyman:
Getting Poria cocos medicine materical crude slice, pulverize into fine powder, add water boil and extract 2-3 time, remove water-soluble polysaccharide composition, add the 0.1-2mol/L sodium hydroxide solution of dregs of a decoction weight 5-40 times amount, stirring and evenly mixing, place 4-24 hour in 4-20 DEG C, decompression filters, and obtains filtrate;
Adding hydrochloric acid or acetic acid regulates filtrate pH value to 6-7, centrifugal must precipitate, and the superoxol that throw out adds 5%, stirs evenly, places 1-10 hour, repeatedly washes removal water-soluble impurity, obtains pachyman, for subsequent use;
(2) get described amount glycerine, deionized water, add pachyman, stir evenly;
(3) described amount Trimethyl glycine, baicalin, glycyrrhizin, centella asiatica glucoside, deionized water are joined in the mixture of step (2);
(4) by the mixture of step (3) gained, 200 eye mesh screens are crossed;
(5) ultraviolet disinfection 40-60 minute.
Recording according to " this grass product will through meeting ", Poria cocos can remove the blackspot that sore long on face, spot and women produce postpartum well. The application of Poria cocos in makeup, great majority are broken into fine powder with other Chinese medicinal materials powder mix, makes facial mask, is that product sanitary control or product effect are all difficult to reach satisfactory state. The present invention is semi-transparent clear mile shape by pachyman outward appearance prepared by special process, skinfeel is fine and smooth, there is good retentiveness, film-forming properties, there is good moisture retention, through skin irritation test, safe and non-stimulating, both met aesthetic appearance and the security requirement of existingization makeup, there is again moisture-keeping functions, it is a kind of good skin care product matrix.
Trimethyl glycine, also amino acid humectant it is, it it is a kind of natural structure material amphoteric ion type moisturizing composition, in the application of personal care product, water tariff collection power, the activated cell vigor of skin and hair can be improved rapidly, have and keep skin to moisten, smooth, prevent effect that is dry and obfuscation.
Baicalin is one of main component of the heat-clearing and detoxifying herb root of large-flowered skullcap, pharmacological evaluation shows that baicalin has antibacterial, heat-clearing, step-down, calmness, diuresis, profit courage, anti-inflammation, anti-allergic isoreactivity, the biosynthesizing of white corpuscle LTB4 and LTC4 is all had stronger restraining effect by anti-inflammatory action mechanism experiment display baicalin, 5-lipoxygenase (5-LO) is had restraining effect, and baicalin can affect the function of white corpuscle in multiple link and play anti-inflammatory action.
Glycyrrhizin can improve the threshold of pain of mouse hot-plate experiment, it is to increase dimethylbenzene induced mice auricle inflammation inhibitory rate of intumesce, shows that glycyrrhizin various dose group all has significant anti-inflammatory and analgesic effect.
Centella asiatica glucoside is extracting effective components from natural medicinal plant Herba Centellae, can upgrade, strengthen blood vessel, promote skin wound healing and the reparation to epidermic cell by irritation cell human skin keratinocyte and inoblast are had and obviously promote propagation and DNA Synthesis; Can prevent again granulation from excessively increasing, prevent the formation of skin scar.
Easily irritated skin is generally drier, it is easy to by external stimulus itch, shouting pain, even produce inflammation.Therefore skin moisture-keeping is protection skin and recovers one of the most basic of skin barrier function and the most important principle. The present invention selects the pachyman of the amino acid humectant of natural structure and natural origin composite, not only can improve rapidly the water tariff collection power of skin, firmly pin moisture, activated cell vigor, skin can be improved again to the absorption of the natural anti-inflammatory activity compositions such as baicalin, glycyrrhizin, centella asiatica glucoside, thus playing anti-inflammatory anti-itch effect, it is to increase skin resists quick ability and repair ability.
Inventive formulation is simple, and raw material almost all derives from plant constituent, avoids the stimulation of chemosynthesis composition, can effectively improve the symptoms such as redness that easy quick skin occurs, itch, decortication, allow the comfortable safety of skin feel lay equal stress on and newly set up skin barrier function; Its preparation technology is simple, and cost is lower.
Embodiment
Below by embodiment, the present invention being described further, following examples are the concrete enforcement mode of the present invention, but embodiments of the present invention are by the restriction of following embodiment.
Baicalin that following examples of the present invention adopt, glycyrrhizin, centella asiatica glucoside are commercially available prod.
Embodiment 1:
Improving the skin care product that skin resists quick ability and repair ability, in its composition of raw materials, parts by weight of raw materials number is:
Pachyman 80 parts, glycerine 5 parts, Trimethyl glycine 5 parts, baicalin 0.5 part, glycyrrhizin 0.5 part, centella asiatica glucoside 0.1 part, deionized water 8.9 parts.
Its preparation method, comprises the following steps:
(1) extraction of pachyman:
Getting Poria cocos medicine materical crude slice, pulverize into fine powder (all by 80 orders), add water boil and extract 2 times, remove the compositions such as water-soluble polysaccharide, add the 1mol/L sodium hydroxide solution of dregs of a decoction weight 20 times amount, stirring and evenly mixing, place 24 hours in 4 DEG C, decompression filters, and obtains filtrate;
Adding appropriate hydrochloric acid or acetic acid regulates filtrate pH value to 6-7, centrifugal must precipitate, and the superoxol that throw out adds 5%, stirs evenly, places 10 hours, repeatedly washes removal water-soluble impurity, obtains pachyman, for subsequent use;
(2) get described amount glycerine, add pachyman, stir evenly;
(3) described amount Trimethyl glycine, baicalin, glycyrrhizin, centella asiatica glucoside, deionized water are joined in the mixture of step (2);
(4) by the mixture of step (3) gained, 200 eye mesh screens are crossed;
(5) ultraviolet disinfection 40-60 minute, to obtain final product.
Embodiment 2:
Improving the skin care product that skin resists quick ability and repair ability, in its composition of raw materials, parts by weight of raw materials number is:
Pachyman 60 parts, glycerine 2 parts, Trimethyl glycine 2 parts, baicalin 0.2 part, glycyrrhizin 0.2 part, centella asiatica glucoside 0.5 part, deionized water 35.1 parts.
Its preparation method, comprises the steps:
(1) extraction of pachyman:
Getting Poria cocos medicine materical crude slice, pulverize into fine powder (all by 80 orders), add water boil and extract 2 times, remove the compositions such as water-soluble polysaccharide, add the 0.5mol/L sodium hydroxide solution of dregs of a decoction weight 15 times amount, stirring and evenly mixing, place 12 hours in 10 DEG C, decompression filters, and obtains filtrate;
Adding appropriate hydrochloric acid or acetic acid regulates filtrate pH value to 6-7, centrifugal must precipitate, and the superoxol that throw out adds 5%, stirs evenly, places 5 hours, repeatedly washes removal water-soluble impurity, obtains pachyman, for subsequent use;
(2) get described amount glycerine, add pachyman, stir evenly;
(3) described amount Trimethyl glycine, baicalin, glycyrrhizin, centella asiatica glucoside, deionized water are joined in the mixture of step (2);
(4) by the mixture of step (3) gained, 200 eye mesh screens are crossed;
(5) ultraviolet disinfection 40-60 minute, to obtain final product.
Embodiment 3:
Improving the skin care product that skin resists quick ability and repair ability, in its composition of raw materials, parts by weight of raw materials number is:
Pachyman 30 parts, glycerine 3 parts, Trimethyl glycine 3 parts, baicalin 0.2 part, glycyrrhizin 0.2 part, centella asiatica glucoside 0.1 part, deionized water 63.5 parts.
Its preparation method, comprises the steps:
(1) extraction of pachyman:
Getting Poria cocos medicine materical crude slice, pulverize into fine powder (all by 80 orders), add water boil and extract 2 times, remove the compositions such as water-soluble polysaccharide, add the 2mol/L sodium hydroxide solution of dregs of a decoction weight 10 times amount, stirring and evenly mixing, place 12 hours in 20 DEG C, decompression filters, and obtains filtrate;
Adding appropriate hydrochloric acid or acetic acid regulates filtrate pH value to 6-7, centrifugal must precipitate, and the superoxol that throw out adds 5%, stirs evenly, places 2 hours, repeatedly washes removal water-soluble impurity, obtains pachyman, for subsequent use;
(2) get described amount glycerine, add pachyman, stir evenly;
(3) described amount Trimethyl glycine, baicalin, glycyrrhizin, centella asiatica glucoside, deionized water are joined in the mixture of step (2);
(4) by the mixture of step (3) gained, 200 eye mesh screens are crossed;
(5) ultraviolet disinfection 40-60 minute, to obtain final product.
Patch test:
Test method: on inner forearm healthy skin, by the SDS(sodium lauryl sulphate of appropriate concentration) stimulate, make it to become red and swollen, then the present embodiment 1 sample and negative control solution (physiological saline) spot examination device is coated respectively, light pressure makes sample liquid evenly stick on damaged skin, observe the repairing effect of skin, the results are shown in following table 1.
Table 1
Test-results shows, product of the present invention can effectively improve erythema that damaged skin occurs, redness, the symptom such as decortication, plays anti-inflammatory anti-itch effect, can improve skin and resist quick ability and repair ability.
Claims (3)
1. one kind is improved skin and resists skin care product that are quick and repair ability, it is characterised in that, it is made up of the raw material of following portions by weight:
Pachyman 30-90 part, glycerine 0.1-10 part, Trimethyl glycine 0.1-5 part, baicalin 0.01-3 part, glycyrrhizin 0.01-5 part, centella asiatica glucoside 0.01-5 part, deionized water 0-69.77 part;
Wherein, the extracting method of described pachyman is as follows:
Getting Poria cocos medicine materical crude slice, pulverize into fine powder, add water boil and extract 2-3 time, remove water-soluble polysaccharide composition, add the 0.1-2mol/L sodium hydroxide solution of dregs of a decoction weight 5-40 times amount, stirring and evenly mixing, place 4-24 hour in 4-20 DEG C, decompression filters, and obtains filtrate;
Adding hydrochloric acid or acetic acid regulates filtrate pH value to 6-7, centrifugal must precipitate, and the superoxol that throw out adds 5%, stirs evenly, places 1-10 hour, repeatedly washes removal water-soluble impurity, obtains pachyman.
2. raising skin according to claim 1 resists skin care product that are quick and repair ability, it is characterised in that, the weight part number of each raw material is:
Pachyman 80 parts, glycerine 5 parts, Trimethyl glycine 5 parts, baicalin 0.5 part, glycyrrhizin 0.5 part, centella asiatica glucoside 0.1 part, deionized water 8.9 parts.
3. raising skin described in claim 1 or 2 resists the preparation method of the skin care product of quick and repair ability, it is characterised in that, comprise the following steps:
(1) extraction of pachyman:
Getting Poria cocos medicine materical crude slice, pulverize into fine powder, add water boil and extract 2-3 time, remove water-soluble polysaccharide composition, add the 0.1-2mol/L sodium hydroxide solution of dregs of a decoction weight 5-40 times amount, stirring and evenly mixing, place 4-24 hour in 4-20 DEG C, decompression filters, and obtains filtrate;
Adding hydrochloric acid or acetic acid regulates filtrate pH value to 6-7, centrifugal must precipitate, and the superoxol that throw out adds 5%, stirs evenly, places 1-10 hour, repeatedly washes removal water-soluble impurity, obtains pachyman, for subsequent use;
(2) get described amount glycerine, add pachyman, stir evenly;
(3) described amount Trimethyl glycine, baicalin, glycyrrhizin, centella asiatica glucoside, deionized water are joined in the mixture of step (2);
(4) by the mixture of step (3) gained, 200 eye mesh screens are crossed;
(5) ultraviolet disinfection 40-60 minute.
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| CN201410385639.6A CN104127331B (en) | 2014-08-07 | 2014-08-07 | A kind of skin care product and its preparation method improving skin and resisting quick and repair ability |
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| CN201410385639.6A CN104127331B (en) | 2014-08-07 | 2014-08-07 | A kind of skin care product and its preparation method improving skin and resisting quick and repair ability |
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| CN104127331B true CN104127331B (en) | 2016-06-08 |
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