CN109464508B - Traditional Chinese medicine composition for repairing blue light injury and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for repairing blue light injury and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for repairing blue light injury and a preparation method and application thereof, wherein the composition comprises the following components in parts by weight: 5-50 parts of lespedeza bicolor, 10-35 parts of peach blossom, 10-40 parts of white paeony root and 15-50 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention combines the monarch, minister, assistant and guide prescription principle of a traditional Chinese medicine formula, the lespedeza, the peach blossom, the white paeony root and the liquorice are combined and proportioned, and the four ingredients are synergistic, so that the problems of dry skin due to water shortage and dark yellow and dull caused by skin dysrhythmia can be effectively solved, and the problem of color spot pigment precipitation caused by weakened skin free radical scavenging capacity caused by blue light is solved.
Description
Technical Field
The invention belongs to the field of cosmetics, relates to a traditional Chinese medicine composition, a preparation method and application thereof, and particularly relates to a traditional Chinese medicine composition for repairing blue light injury, a preparation method and application thereof.
Background
The blue light is high-energy visible light with a wavelength of 380-500 nanometers and extremely strong penetrating power. The natural light also has blue light, but the blue light has stronger penetrability and harm than artificial blue light from mobile phone screens, computer screens and LED lamps. Nell et al, as early as 1966, found that irradiation with blue light caused damage to retinal cells, resulting in decreased or even lost vision. Wherein, the short-wave blue light with the wavelength of 400-450 nm has the greatest harm degree to the retina. In the 2010 annual meeting of the international light association, world-center optical experts consistently pointed out: the short-wave blue light has extremely high energy and can penetrate through crystalline lens to directly reach retina. Blue light irradiation of the retina produces free radicals which cause retinal pigment epithelial cell death, which results in the depletion of light-sensitive cells that lack nutrients and cause vision loss, and these losses are irreversible.
The harm of blue light to human body is mainly eye pathological damage, human sleep influence and skin damage.
Firstly, the pathological hazard of eyes is structural, harmful blue light has extremely high energy and can penetrate crystalline lens to reach retina directly, so that atrophy and even death of retinal pigment epithelial cells are caused. The death of light-sensitive cells will lead to a loss of vision or even complete loss, which is irreversible
Secondly, the influence on the sleep of the human body is shown as follows: the blue light stimulates the brain, inhibits the secretion of melatonin, and improves the generation of adrenocortical hormone so as to destroy the hormone secretion balance, cause the dysrhythmia of the human body, influence the cell repair function, and cause the problems of facial water deficiency, dark yellow, edema and the like.
And thirdly, most of the damage to the skin comes from high-energy short-wave blue light equivalent to ultraviolet energy in the liquid crystal screen. Prolonged irradiation causes soreness to the eyes, dry skin, and stimulates the production of a brown pigment of melanine, which originally functions to protect the skin from ultraviolet light, but becomes scaling when his protective task is completed. When the metabolism of the body is poor and the free radical removing capability is insufficient, the detoxification mechanism is weakened, and a part of pigment is remained on the surface layer of the skin after long-term sitting, so that the skin is dark yellow and dull, and even yellow spots and freckles are formed.
CN106727027A discloses a composition for resisting blue light, resisting oxidation and removing free radicals, a skin care product and a preparation method thereof. The composition comprises the following components in parts by mass: 0.1-5 parts of a compound of marigold flower extract and safflower seed oil, 1-10 parts of tea extract and 1-10 parts of alpine edelweiss extract. The compound of the marigold flower extract and the safflower seed oil can enhance the blue light filtering capability of human skin, prevent the damage of blue light to the skin, capture free radicals in human skin tissues and delay the aging caused by skin oxidation; the tea extract can make skin tender and smooth, and is helpful for cleaning skin and preventing acne; the alpine edelweiss extract has the effects of relieving, calming, resisting oxidation and nourishing and protecting skin, but the moisturizing effect of the composition is weak.
CN106176502A discloses a skin care composition with blue light resistance, which mainly comprises 0.1-5 parts of marigold (TAGETES ERECTA) flower extract and 0.1-5 parts of VACCINIUM ANGUSTIFOLIUM (Vaccinium ANGUSTIFOLIUM) fruit extract, and the two extracts have synergistic eye protection effect and can well solve the eye problem caused by LED blue light radiation. However, this invention is only used for eye repair, and does not disclose the function of repairing facial skin.
At present, no suitable skin care product exists for the problems of skin dehydration, dryness, edema, swelling, dark yellow and laxity, color spot precipitation and the like caused by skin dysrhythmia caused by blue light, so that the development of a traditional Chinese medicine composition for repairing the blue light injury has high value.
Disclosure of Invention
Aiming at the defects and actual requirements of the prior art, the invention provides the traditional Chinese medicine composition for repairing blue light injury and the preparation method and the application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a traditional Chinese medicine composition for repairing blue light injury, which is mainly prepared from the following raw materials in parts by weight: 5-50 parts of lespedeza bicolor, 10-35 parts of peach blossom, 10-40 parts of white paeony root and 15-50 parts of liquorice.
The parts by weight of the lespedeza bicolor is 5-50 parts, for example, 5 parts, 8 parts, 10 parts, 15 parts, 18 parts, 20 parts, 23 parts, 25 parts, 28 parts, 30 parts, 32 parts, 35 parts, 40 parts, 45 parts or 50 parts, preferably 20-40 parts, and more preferably 30-40 parts.
The weight portion of the peach blossom is 10 to 35 portions, for example, 10 portions, 12 portions, 14 portions, 15 portions, 17 portions, 18 portions, 20 portions, 22 portions, 23 portions, 25 portions, 27 portions, 29 portions, 30 portions, 32 portions, 34 portions or 35 portions, preferably 15 to 30 portions, and more preferably 20 to 25 portions.
The white peony root is 10-40 parts by weight, for example, 10 parts, 12 parts, 14 parts, 15 parts, 18 parts, 20 parts, 23 parts, 25 parts, 28 parts, 30 parts, 32 parts, 34 parts, 35 parts, 38 parts or 40 parts, preferably 15-30 parts, and more preferably 20-30 parts.
The weight portion of the licorice is 15 to 50 portions, for example, 15 portions, 18 portions, 20 portions, 23 portions, 25 portions, 27 portions, 30 portions, 32 portions, 35 portions, 38 portions, 40 portions, 43 portions, 45 portions, 47 portions or 50 portions, preferably 20 to 40 portions, and more preferably 20 to 25 portions.
The traditional Chinese medicine composition disclosed by the invention is combined with the monarch, minister, assistant and guide prescription principle of a traditional Chinese medicine formula, takes lespedeza as a monarch drug, peach blossom as a minister drug, radix paeoniae alba as an assistant drug and liquorice as a guide drug, takes traditional Chinese medicines with the effects of moistening lung and clearing heat, strengthening tendons and tonifying kidney, relieving cough and eliminating phlegm, diminishing inflammation and resisting bacteria as main materials, takes traditional Chinese medicines with the effects of inducing diuresis to alleviate edema, promoting blood circulation to remove blood stasis, nourishing blood and liver, expelling toxin and treating blood deficiency sallow complexion as auxiliary materials, and has the following properties and:
the following steps of (1) lespedeza: slightly pungent and astringent taste and warm nature, the whole herb can be used as medicine. The traditional Chinese medicine proves that the traditional Chinese medicine has the effects of moistening lung, clearing heat, strengthening tendons, tonifying kidney, relieving cough, eliminating phlegm, diminishing inflammation, resisting bacteria, resisting viruses, reducing blood fat and cholesterol, resisting cancers and the like; the records in Min Dong Ben Cao can strengthen the bone, invigorate the spleen and eliminate dampness, and the Song Dynasty as early as more than 1000 years ago can be used as one of the moxibustion materials.
Peach blossom: dredging channels and collaterals, nourishing skin, and improving xerosis cutis and pachylosis. The Qianjin pteride has the function of making people color and beautiful face.
White peony root: tonify qi, replenish blood, whiten and moisten skin. The record in Ben Cao Bei Yao (herbal remedy) has the effects of enriching blood, purging liver fire, benefiting spleen, astringing liver yin and treating abdominal pain due to blood deficiency.
Licorice root: harmonizing the drugs, and having anti-inflammatory and anti-allergic effects. Recorded in Qianjin Fang, Licorice root can relieve various toxins.
Modern medicine is in the spotlight of researches on lespedeza bicolor, and researches on recent modern medicine find that lespedeza bicolor is rich in ketone compounds, can eliminate hydroxyl radicals and superoxide anions generated in vivo and inhibit the regeneration of lespedeza bicolor; the polyphenol component can capture peroxy free radical to block peroxidation chain reaction; contains alkaloid, and has analgesic and toxic materials clearing away effects. Intensive research and excavation discover that the lespedeza bicolor extract can regulate circadian rhythm genes of skin cells, restore skin rhythm, strengthen cell repair function, activate aquaporins, strengthen skin Nrf2 pathway and eliminate oxidative stress. The traditional Chinese medicine composition has the effects of conditioning skin rhythm, soothing liver, promoting blood circulation, expelling toxin, brightening, replenishing water, preserving moisture and beautifying after being used together, and has obvious effect of repairing skin injury caused by blue light when being added into cosmetics.
In a second aspect, the present invention provides a method for preparing the Chinese medicinal composition of the first aspect, the method comprising the steps of:
(1) extraction: mixing the raw materials of the traditional Chinese medicine composition in proportion, adding an extraction solvent, and heating and extracting to obtain an extracting solution;
(2) and (3) purification: filtering and concentrating the extracting solution obtained in the step (2) to obtain a concentrated solution I, purifying, and collecting eluent;
(3) concentration: and (4) concentrating the eluent obtained in the step (3) to obtain a concentrated solution II, adding an organic solvent to dissolve, and filtering to obtain the traditional Chinese medicine composition.
Preferably, step (1) is preceded by a step of pre-treatment, comprising the steps of: pulverizing the Chinese medicinal materials, sieving, and mixing.
Preferably, the mesh size of the screen is 60-100 mesh, for example, 60 mesh, 65 mesh, 70 mesh, 75 mesh, 80 mesh, 85 mesh, 90 mesh, 95 mesh or 100 mesh.
Preferably, the mass-volume ratio of the raw materials of the traditional Chinese medicine composition in the step (1) to the extraction solvent is 1 (15-20), and can be 1:15, 1:16, 1:17, 1:18, 1:19 or 1:20, for example.
Preferably, the extraction solvent comprises ethanol.
Preferably, the ethanol has a volume fraction of 60-80%, for example, 60%, 65%, 70%, 75% or 80%.
Preferably, the heating in step (1) is carried out at a temperature of 50 to 80 ℃ and may be, for example, 50 ℃, 55 ℃, 60 ℃, 65 ℃, 70 ℃, 75 ℃ or 80 ℃.
Preferably, the extraction time in step (1) is 1-3h, for example 1h, 2h or 3 h.
Preferably, the number of times of extraction in step (1) is 1-3, and may be, for example, 1, 2 or 3.
And (3) concentrating under reduced pressure in the step (2).
Preferably, the concentration in step (2) is carried out at a temperature of 50-80 deg.C, such as 50 deg.C, 55 deg.C, 60 deg.C, 65 deg.C, 70 deg.C, 75 deg.C or 80 deg.C.
Preferably, the concentration of step (2) is 1/5-1/15 concentrated to the original volume, which may be 1/15, 1/10, 1/8 or 1/5, for example.
Preferably, the purification of step (2) is purification by a macroporous resin column.
Preferably, the resin is of type D101 and/or AB-8.
Preferably, the eluate collected in step (2) is in a fraction of 30-80% by volume, for example 30%, 40%, 50%, 60%, 70% or 80%.
In the invention, after the concentrated solution is loaded on the column, the resin column is eluted by ethanol with the volume fraction of 80 percent, and the eluent with the volume fraction of 30 to 80 percent is collected.
Preferably, the concentration in step (3) is carried out at a temperature of 30-50 deg.C, such as 30 deg.C, 35 deg.C, 40 deg.C, 45 deg.C or 50 deg.C.
Preferably, the concentration of step (3) is concentration under reduced pressure.
Preferably, the mass ratio of the concentrated solution II in the step (3) to the raw materials of the traditional Chinese medicine composition in the step (1) is 1 (0.5-10), and may be, for example, 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9 or 1: 10.
Preferably, the organic solvent of step (3) comprises butanediol.
Preferably, the mass ratio of the organic solvent to the concentrated solution II in the step (3) is 1 (1-1.5), and may be 1:1, 1:1.2 or 1:1.5, for example.
Preferably, the method specifically comprises the following steps:
(1) pretreatment: pulverizing the raw materials of the Chinese medicinal composition, sieving with a 60-100 mesh sieve, and mixing; extraction: adding the pretreated raw materials of the traditional Chinese medicine composition into an extraction solvent, wherein the mass volume ratio of the raw materials of the traditional Chinese medicine composition to the extraction solvent is 1 (15-20), the extraction solvent is ethanol with the volume fraction of 60-80%, and the traditional Chinese medicine composition is heated and extracted for 1-3 hours at 50-80 ℃ for 1-3 times to obtain an extracting solution.
(2) And (3) purification: filtering the extracting solution obtained in the step (1), concentrating at 50-80 ℃ under reduced pressure to 1/5-1/15 of the original volume to obtain a concentrated solution I, purifying the concentrated solution I by a macroporous resin column with the resin type of D101 or AB-8, and collecting an ethanol elution part with the volume fraction of 30% -80% to obtain an eluent;
(3) concentration: concentrating the eluent obtained in the step (2) at 30-50 ℃ under reduced pressure until the mass ratio of the eluent to the raw materials of the traditional Chinese medicine composition in the step (1) is 1 (0.5-10), obtaining a concentrated solution II, adding an organic solvent for dissolving, wherein the mass ratio of the organic solvent to the concentrated solution II is 1 (1-1.5), and filtering to obtain the traditional Chinese medicine composition.
The preparation method of the traditional Chinese medicine composition provided by the invention is characterized in that an optimal extraction scheme is formulated according to the properties and tastes of lespedeza bicolor, peach blossom, white paeony root and liquorice, so that the extracted traditional Chinese medicine composition has high content of effective components and stable performance, and is beneficial to subsequent application and products such as cosmetics.
In a third aspect, the present invention provides a cosmetic comprising the Chinese medicinal composition of the first aspect.
Preferably, the cosmetic comprises any one of, or a combination of at least two of, an emulsion, a mask, a cream, or a lotion.
Preferably, the amount of the traditional Chinese medicine composition added is 0.01-30%, for example, 0.01%, 0.05%, 0.1%, 0.2%, 0.5%, 1%, 2%, 3%, 5%, 8%, 10%, 12%, 13%, 15%, 18%, 20%, 22%, 25%, 28% or 30%, preferably 10-15%.
In a fourth aspect, the invention provides a blue light repairing mask, which is characterized by being prepared from the traditional Chinese medicine composition of the first aspect.
Preferably, the blue light repairing mask further comprises a water phase, an oil phase and auxiliary materials.
Preferably, the aqueous phase comprises any one or a combination of at least two of glycerol, hydrogenated lecithin, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, allantoin or panthenol.
Preferably, the oil phase comprises any one of squalane, polydimethylsiloxane, isopropyl palmitate, methyl paraben or propyl paraben, or a combination of at least two of these.
Preferably, the adjuvant comprises aminomethyl propanol.
Preferably, the blue light repairing mask comprises the following components in percentage by mass:
in a fifth aspect, the invention provides an anti-blue light moisturizing and protecting lotion, which is prepared by using the traditional Chinese medicine composition as claimed in claim 1 or 2.
Preferably, the blue light resisting and moisturizing repair emulsion further comprises a water phase, an oil phase and auxiliary materials.
Preferably, the aqueous phase comprises any one of disodium EDTA, panthenol, glycerol or sodium lecithin/acrylic copolymer or a combination of at least two of them.
Preferably, the oil phase comprises any one of squalane, polydimethylsiloxane, jojoba oil, shea butter, C14-22 alcohol, C12-20 alkyl glucoside, methyl or propyl hydroxybenzoate, or a combination of at least two thereof.
Preferably, the adjuvant comprises any one or a combination of at least two of 1, 3-butanediol, beta-glucan, aloe barbadensis leaf extract or aminomethyl propanol.
Preferably, the blue light resisting and moisturizing repair emulsion comprises the following components in percentage by mass:
compared with the prior art, the invention has the following beneficial effects:
(1) the traditional Chinese medicine composition disclosed by the invention is combined with the monarch, minister, assistant and guide prescription principle of a traditional Chinese medicine formula, the lespedeza, the peach blossom, the white paeony root and the liquorice are combined and proportioned, and the four ingredients are synergistic, so that the problem of skin cell dysrhythmia caused by blue light in an electronic screen can be effectively adjusted and recovered;
(2) the traditional Chinese medicine composition can be used for preparing various cosmetics, can effectively solve the problems of dry skin due to water shortage and dark yellow and dull caused by skin dysrhythmia, and simultaneously solves the problem of color spot pigment precipitation caused by weakened skin free radical scavenging capacity caused by blue light;
(3) the composition disclosed by the invention is safe and has no side effect, and can simultaneously solve various problems of skin by adopting natural traditional Chinese medicinal materials as main raw materials.
Drawings
FIG. 1 is the skin complexion test results of example 6 of the present invention and comparative example 11;
FIG. 2 shows the results of human trial evaluation of example 6 of the present invention and comparative example 11;
fig. 3 is a result of evaluating moisturizing efficacy of example 8 of the present invention and comparative example 12.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following embodiments further illustrate the technical solutions of the present invention, but the present invention is not limited to the scope of the embodiments.
Example 1A Chinese medicinal composition for repairing blue light injury
A traditional Chinese medicine composition for repairing blue light injury comprises the following components in parts by weight:
35g of lespedeza bicolor, 23g of peach blossom, 20g of white paeony root and 22g of liquorice.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing the raw materials of the traditional Chinese medicine composition, sieving with a 80-mesh sieve, and mixing uniformly; extraction: adding the pretreated Chinese medicinal composition raw materials into 80% ethanol by volume, wherein the mass-volume ratio of the Chinese medicinal composition raw materials to the extraction solvent is 1:15, namely 1.5L, heating and extracting at 80 deg.C for 2h, and extracting for 3 times to obtain extractive solution.
(2) And (3) purification: filtering the extracting solution obtained in the step (1), concentrating the extracting solution to 300mL at 60 ℃ under reduced pressure to obtain a concentrated solution I, purifying the concentrated solution I by using a macroporous resin column with the resin model D101 or AB-8, and collecting an ethanol elution part with the volume fraction of 80% to obtain an eluent;
(3) concentration: and (3) concentrating the eluent obtained in the step (2) at 50 ℃ under reduced pressure to 50g to obtain a concentrated solution II, adding 50g of butanediol for dissolving, and filtering to obtain 100g of the traditional Chinese medicine composition for repairing the blue light injury.
Example 2
A traditional Chinese medicine composition for repairing blue light injury comprises the following components in parts by weight:
32g of lespedeza bicolor, 25g of peach blossom, 28g of white paeony root and 15g of liquorice.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing the raw materials of the traditional Chinese medicine composition, sieving with a 80-mesh sieve, and mixing uniformly; extraction: adding the pretreated Chinese medicinal composition raw materials into 80% ethanol by volume, wherein the mass-volume ratio of the Chinese medicinal composition raw materials to the extraction solvent is 1:15, namely 1.5L, heating and extracting at 80 deg.C for 2h, and extracting for 3 times to obtain extractive solution.
(2) And (3) purification: filtering the extracting solution obtained in the step (1), concentrating the extracting solution to 300mL at 60 ℃ under reduced pressure to obtain a concentrated solution I, purifying the concentrated solution I by using a macroporous resin column with the resin model D101 or AB-8, and collecting an ethanol elution part with the volume fraction of 80% to obtain an eluent;
(3) concentration: and (3) concentrating the eluent obtained in the step (2) at 50 ℃ under reduced pressure to 50g to obtain a concentrated solution II, adding 50g of butanediol for dissolving, and filtering to obtain 100g of the traditional Chinese medicine composition for repairing the blue light injury.
Example 3
A traditional Chinese medicine composition for repairing blue light injury comprises the following components in parts by weight:
45g of lespedeza bicolor, 18g of peach blossom, 12g of white paeony root and 25g of liquorice.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing the raw materials of the traditional Chinese medicine composition, sieving with a 80-mesh sieve, and mixing uniformly; extraction: adding the pretreated Chinese medicinal composition raw materials into 80% ethanol by volume, wherein the mass-volume ratio of the Chinese medicinal composition raw materials to the extraction solvent is 1:15, namely 1.5L, heating and extracting at 80 deg.C for 2h, and extracting for 3 times to obtain extractive solution.
(2) And (3) purification: filtering the extracting solution obtained in the step (1), concentrating at 60 ℃ under reduced pressure to 300mL to obtain a concentrated solution I, purifying the concentrated solution II through a macroporous resin column with the resin type D101 or AB-8, and collecting an ethanol elution part with the volume fraction of 80% to obtain an eluent;
(3) concentration: and (3) concentrating the eluent obtained in the step (2) at 50 ℃ under reduced pressure to 50g to obtain a concentrated solution II, adding 50g of butanediol for dissolving, and filtering to obtain 100g of the traditional Chinese medicine composition for repairing the blue light injury.
Example 4
A traditional Chinese medicine composition for repairing blue light injury comprises the following components in parts by weight:
25g of lespedeza bicolor, 27g of peach blossom, 18g of white paeony root and 30g of liquorice.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing the raw materials of the traditional Chinese medicine composition, sieving with a 70-mesh sieve, and mixing uniformly; extraction: adding the pretreated Chinese medicinal composition raw materials into 70% ethanol by volume, wherein the mass-volume ratio of the Chinese medicinal composition raw materials to the extraction solvent is 1:20, namely 2L, and extracting for 2 times at 65 deg.C for 3h to obtain extractive solution.
(2) And (3) purification: filtering the extracting solution obtained in the step (1), concentrating the extracting solution to 200mL at 80 ℃ under reduced pressure to obtain a concentrated solution I, purifying the concentrated solution I by using a macroporous resin column with the resin model D101 or AB-8, and collecting an ethanol elution part with the volume fraction of 50% to obtain an eluent;
(3) concentration: and (3) concentrating the eluent obtained in the step (2) at 40 ℃ under reduced pressure to 50g to obtain a concentrated solution II, adding 50g of butanediol for dissolving, and filtering to obtain 100g of the traditional Chinese medicine composition for repairing the blue light injury.
Example 5
A traditional Chinese medicine composition for repairing blue light injury comprises the following components in parts by weight:
5g of lespedeza bicolor, 35g of peach blossom, 10g of white peony root and 50g of liquorice.
The preparation method comprises the following steps:
(1) pretreatment: pulverizing the raw materials of the traditional Chinese medicine composition, sieving with a 60-mesh sieve, and mixing uniformly; extraction: adding the pretreated Chinese medicinal composition raw materials into 60% ethanol by volume, wherein the mass-volume ratio of the Chinese medicinal composition raw materials to the extraction solvent is 1:15, namely 1.5L, heating and extracting at 50 ℃ for 1h, and extracting for 3 times to obtain an extracting solution.
(2) And (3) purification: filtering the extracting solution obtained in the step (1), concentrating the extracting solution to 100mL at 50 ℃ under reduced pressure to obtain a concentrated solution I, purifying the concentrated solution I by using a macroporous resin column with the resin model D101 or AB-8, and collecting an ethanol elution part with the volume fraction of 30% to obtain an eluent;
(3) concentration: and (3) concentrating the eluent obtained in the step (2) at 30 ℃ under reduced pressure to 50g to obtain a concentrated solution II, adding 50g of butanediol for dissolving, and filtering to obtain 100g of the traditional Chinese medicine composition for repairing the blue light injury.
Comparative example 1
Compared with example 1, the conditions are the same as example 1 except that the addition amount of each component is 55g of lespedeza bicolor, 13g of peach blossom, 15g of white paeony root and 17g of liquorice.
Comparative example 2
Compared with example 1, the conditions are the same as example 1 except that the addition amount of each component is 3g of lespedeza bicolor, 33g of peach blossom, 32g of white paeony root and 32g of liquorice.
Comparative example 3
The procedure of example 1 was repeated except that Lespedeza bicolor was not added and 35g of peach blossom, 30g of white peony root and 35g of licorice was added, as compared with example 1.
Comparative example 4
The procedure of example 1 was repeated except that peach blossom was not added, and lespedeza bicolor 40g, paeonia lactiflora 30g, and glycyrrhiza uralensis 30g were added as compared with example 1.
Comparative example 5
The procedure of example 1 was repeated except that no white peony root was added, and 40g of lespedeza, 30g of peach blossom and 30g of licorice were added as compared with example 1.
Comparative example 6
The procedure of example 1 was repeated except that no licorice was added, and 40g of lespedeza, 30g of peach blossom and 30g of white peony root were added as compared with example 1.
Comparative example 7
The procedure of example 1 was repeated except that 100g of lespedeza bicolor was added as compared with example 1.
Comparative example 8
The procedure of example 1 was followed except that 100g of peach blossom was added, as compared with example 1.
Comparative example 9
Compared with example 1, except that only 100g of white peony root is added, the conditions are the same as example 1.
Comparative example 10
The procedure of example 1 was repeated except that 100g of licorice was added as compared with example 1.
DPPH free radical scavenging Experimental test
(1) Preparation of the test specimens
The following experiments were performed by preparing 1% concentration sample solutions of the herbal compositions of examples 1 to 5 and the extracts of the single herbs of comparative examples 1 to 10, respectively.
(2) The test method comprises the following steps: examples 1-5 and comparative example 10 sample loading experiments were performed as in table 1. Accurately transferring the reaction solution into a 5mL centrifuge tube, mixing well, standing in the dark for 30min, measuring absorbance at 517nm, and using ethanol as blank control to obtain A1、A2、A3. The experiments were performed in parallel 3 times, and the results are shown in Table 2.
TABLE 1 test sample compositions
The DPPH free radical clearance rate calculation formula is as follows:
DPPH radical clearance rate ═ 1- (A)2-A3)/A1]×100％
TABLE 2 DPPH clearance
As can be seen from table 1, the DPPH clearance of the herbal extract of example 1 is the highest, and as can be seen from comparing example 1 with comparative examples 1-2, the herbal composition obtained when the weight parts of lespedeza bicolor are within the range of the present invention has the best effect on DPPH clearance, and the DPPH clearance is significantly reduced when the addition amount of lespedeza bicolor is insufficient or exceeds the range; comparing example 1 with comparative examples 3-6, it can be seen that the invention synergizes the effects of the four components by combining and proportioning lespedeza, peach blossom, white peony root and licorice, and the deletion of any component can cause the decrease of DPPH clearance rate; comparing example 1 with comparative examples 7-10, it can be seen that the DPPH clearance of the single components of lespedeza bicolor, peach blossom, white peony root or licorice is low, and it is further verified that the DPPH clearance of 95.4% can be achieved only by combining the four components under the specific ratio conditions.
Example 6A blue light repairing mask
The specific formula of the blue light repairing mask prepared by adopting the traditional Chinese medicine composition for repairing blue light damage, which is described in the optimal embodiment 1, is shown in table 3.
TABLE 3 blue light repair mask formula
The preparation steps of the blue light repairing mask are as follows:
(1) putting the water phase into a water phase preparation pot, uniformly stirring, heating and stirring to 80-85 ℃;
(2) putting the oil phase into an oil phase preparation pot, uniformly stirring, and heating and stirring to 80-85 ℃;
(3) pumping the materials in the water phase pot into an emulsifying pot. Pumping the materials in the oil phase pot into an emulsifying pot, uniformly stirring, vacuumizing the emulsifying pot, and homogenizing and emulsifying for 10 minutes;
(4) preserving the heat for 20 minutes, and then cooling to 30-35 ℃ by boiling cooling water;
(5) adding auxiliary materials and the traditional Chinese medicine composition with the function of repairing the blue light injury obtained in the embodiment 1, stirring uniformly, and discharging after the inspection is qualified.
Example 7
Compared with example 6, the conditions were the same as example 6 except that the amount of the traditional Chinese medicine composition for repairing blue light injury obtained in example 1 was 31% in the mask.
Tests show that when the addition amount of the traditional Chinese medicine composition exceeds 30%, the formula of the facial mask is unstable and can cause irritation to the skin.
Comparative example 11 ordinary moisture mask
The components of a common moisture mask without the traditional Chinese medicine extract are shown in the table 4.
Table 4 general moisturizing mask formula
The preparation method is the same as example 6.
Skin complexion test experiment
The facial mask formulas of example 6 and comparative example 11 were selected to determine the effect of a traditional Chinese medicine extract composition for repairing blue light damage on skin complexion within 14 days.
(1) The experimental principle is as follows: the device can characterize major aspects of the skin such as lightness, dullness, color and surface condition by colorimetrically measuring the skin complexion index using a gonio-spectrophotometric luminance meter. An increase in the skin tone index corresponds to an improved skin tone.
(2) An experimental instrument: angle measuring spectrophotometer
(3) The test method comprises the following steps: the female volunteers were 30 persons in total, aged 20-35 years. The exclusion conditions of the volunteers meet the inclusion and exclusion standards of the diagnosis standard and the treatment principle of the cosmetic contact dermatitis. The volunteers were allowed to work at night to early morning to cause circadian rhythm disorder, and the following day 8:00 was carried out by applying the blue light repairing mask of example 6 to one side and the ordinary moisturizing mask of comparative example 11 to one side of the left and right volunteers as the test sites, and removing the masks after 15 minutes. The test volunteers were unable to apply any cosmetic product to the test area, the test was performed after 7 and 14 days of treatment, the face was cleaned after 14 consecutive days of facial mask application, and the skin color change was measured against 7 and 14 days of treatment. The measured parameters are related to the dullness of skin color, and can also be used as parameters of the degree of life rhythm disorder, and the results are shown in figure 1.
As shown in fig. 1, the blue light repairing mask added with the traditional Chinese medicine composition for repairing blue light injury can improve the skin color of skin by + 30% compared with the common moisturizing mask, and also shows that the improvement degree of circadian rhythm disorder is obviously improved and is superior to the common moisturizing mask.
Human body trial evaluation experiment
The facial mask formulas of example 6 and comparative example 11 were selected to determine the effect of a traditional Chinese medicine extract composition for repairing blue light damage on the overall state of skin health, thereby evaluating the degree of improvement of the composition on the overall skin state after skin rhythm adjustment.
(1) The experimental method comprises the following steps: the male and female volunteers total 100 persons, wherein 50 men and 50 women are aged 25-55 years, and the main symptoms are dark complexion, tired complexion, uneven complexion and edema. Groups were randomized into 2 groups of 25 males and 25 females. The control tests of example 6 and comparative example 11 were carried out for each group. Comparative example 11 was used on the left side and example 6 was used on the right side once a day before sleep at night, and after 1 month, volunteers were evaluated for the state of improvement in skin condition, and the statistical results are shown in fig. 2.
The experimental results are as follows: the results of human trial evaluation tests clearly compare the difference in skin condition improvement efficacy between example 6 and comparative example 11. after using the blue light mask of example 6, 90% of the volunteers showed skin freshness, 87% of the volunteers showed improvement in the signs of skin fatigue, 80% of the volunteers showed more even skin tone, and 76% of the volunteers showed improvement in skin luster. The traditional Chinese medicine extract composition has good effect of regulating skin rhythm, and can effectively recover the health state of skin when being used in cosmetics.
Example 8 blue light-resistant moisturizing repair emulsion
The specific formula of the blue light repairing mask prepared by adopting the traditional Chinese medicine composition for repairing blue light damage in the optimal embodiment 1 is shown in table 5.
TABLE 5 formula of blue light resistant moisturizing conditioner
The preparation method comprises the following steps:
the preparation method of the blue-light-resistant moisturizing repair milk comprises the following steps:
(1) putting the water phase into a water phase preparation pot, uniformly stirring, heating and stirring to 80-85 ℃;
(2) putting the oil phase into an oil phase preparation pot, uniformly stirring, and heating and stirring to 80-85 ℃;
(3) pumping the materials in the water phase pot into an emulsifying pot. Pumping the materials in the oil phase pot into an emulsifying pot, uniformly stirring, vacuumizing the emulsifying pot, and homogenizing and emulsifying for 10 minutes;
(4) preserving the heat for 20 minutes, and then cooling to 30-35 ℃ by boiling cooling water;
(5) adding adjuvants and Chinese medicinal composition with repairing blue light injury, stirring, and discharging after inspection.
Example 9
Compared with the example 8, the conditions are the same as the example 8 except that the addition amount of the traditional Chinese medicine composition for repairing the blue light injury obtained in the example 1 in the emulsion is 31 percent.
Tests show that when the addition amount of the traditional Chinese medicine composition exceeds 30%, the formula of the emulsion is unstable and can cause irritation to the skin.
Comparative example 12A common moisturizing emulsion
The components of a common moisture mask without the traditional Chinese medicine extract are shown in the table 6.
TABLE 6 common moisturizing emulsion formulations
The preparation method comprises the following steps:
(1) proportionally adding the water phase raw materials into a water kettle, heating to 75-80 ℃, and dissolving until the water phase raw materials are clear and transparent for later use; and sequentially adding the oil phase raw materials into an oil pan according to a proportion, heating to 75-80 ℃, and dissolving until the oil phase raw materials are clear and transparent for later use.
(2) Putting the oil phase into a water phase preparation pot, stirring and homogenizing for 2 minutes to 80-85 ℃;
(3) preserving the heat for 20 minutes, and then cooling to 30-35 ℃ by boiling cooling water;
(4) adding auxiliary materials, stirring uniformly, and discharging after the inspection is qualified.
Moisturizing efficacy evaluation test
The formula of example 8 and the formula of comparative example 12 are selected by referring to the light industry standard QB/T4256-.
(1) The experimental principle is as follows: the capacitance method is used for measuring the moisture content of the human skin stratum corneum, and is based on the obvious difference of dielectric constants of water and other substances, the capacitance values of the measured skin are different according to the moisture content of the skin stratum corneum, and the parameters can represent the moisture content of the skin.
(2) An experimental instrument: comermeter CM825 (Courage + Khazaha, Germany)
(3) The experimental method comprises the following steps: 30 healthy volunteers, 16 males and 14 females aged 25-50 years. Using the samples of example 8 and comparative example 12, respectively, equal amounts of the samples were applied to the inner left forearm (4 cm. times.4 cm) and the inner right forearm (4 cm. times.4 cm), and the skin was allowed to stand overnight at 22:00 nights under a constant temperature environment (22. + -.1 ℃) and a relative humidity of 50. + -. 5% for 28 consecutive days at 7:00 am, the skin hydration level was measured at the inner left forearm (4 cm. times.4 cm) and the inner right forearm (4 cm. times.4 cm).
The experimental results are as follows: the maximum and minimum values are removed and the average is taken. The results are shown in FIG. 2. The results show that after 7 days, the skin has a hydration level of 34% for example 8, higher than for comparative example 12, under the same circumstances; after 14 days, the skin hydration level was significantly higher for example 8 than for comparative example 12; the difference in hydration levels between the skin increases significantly over time. The moisturizing and moisturizing emulsion containing the traditional Chinese medicine extract composition for repairing blue light injury has more remarkable moisturizing and moisturizing adjusting effects than common emulsion.
In conclusion, the traditional Chinese medicine composition disclosed by the invention is reasonable in formula, the lespedeza bicolor, the peach blossom, the white paeony root and the liquorice are combined and proportioned, the components are synergistic, the damage of blue light to the skin can be effectively resisted, the damaged skin can be repaired, and meanwhile, the traditional Chinese medicine composition has the effects of moisturizing, nourishing, improving the skin dullness, removing free radicals and the like. The traditional Chinese medicine composition for repairing blue light damage has good compatibility with cosmetics, can be used for preparing various cosmetics, has a remarkable effect within the addition amount range of the traditional Chinese medicine composition, has the functions of moisturizing, brightening skin and resisting oxidation, can effectively resist blue light and damage of the blue light to skin, and has wide market prospect.
The applicant states that the present invention is illustrated in detail by the above examples, but the present invention is not limited to the above detailed methods, i.e. it is not meant that the present invention must rely on the above detailed methods for its implementation. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (17)
1. The antioxidant traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by weight: 5-50 parts of lespedeza bicolor, 10-35 parts of peach blossom, 10-40 parts of white paeony root and 15-50 parts of liquorice;
the preparation method of the antioxidant traditional Chinese medicine composition comprises the following steps:
(1) pretreatment: mixing the raw materials of the traditional Chinese medicine composition according to a proportion, crushing, sieving by a sieve of 60-100 meshes, and uniformly mixing; extraction: adding the pretreated raw materials of the traditional Chinese medicine composition into an extraction solvent, wherein the mass volume ratio of the raw materials of the traditional Chinese medicine composition to the extraction solvent is 1 (15-20), the extraction solvent is ethanol with the volume fraction of 60-80%, and the traditional Chinese medicine composition is heated and extracted for 1-3 hours at 50-80 ℃ for 1-3 times to obtain an extracting solution;
(2) and (3) purification: filtering the extracting solution obtained in the step (1), concentrating at 50-80 ℃ under reduced pressure to 1/5-1/15 of the original volume to obtain a concentrated solution I, purifying the concentrated solution I by a macroporous resin column with the resin type of D101 or AB-8, and collecting an ethanol elution part with the volume fraction of 30% -80% to obtain an eluent;
(3) concentration: concentrating the eluent obtained in the step (2) at 30-50 ℃ under reduced pressure until the mass ratio of the eluent to the raw materials of the traditional Chinese medicine composition in the step (1) is 1 (0.5-10), obtaining a concentrated solution II, adding an organic solvent for dissolving, wherein the mass ratio of the organic solvent to the concentrated solution II is 1 (1-1.5), and filtering to obtain the traditional Chinese medicine composition.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 20-40 parts of lespedeza bicolor, 15-30 parts of peach blossom, 15-30 parts of white peony root and 20-40 parts of liquorice.
3. The traditional Chinese medicine composition according to claim 2, which is prepared from the following raw materials in parts by weight: 30-40 parts of lespedeza bicolor, 20-25 parts of peach blossom, 20-30 parts of white paeony root and 20-25 parts of liquorice.
4. A cosmetic characterized by comprising the Chinese medicinal composition according to any one of claims 1 to 3 as an active ingredient.
5. The cosmetic according to claim 4, wherein the cosmetic is any one of or a combination of at least two of an emulsion, a mask, a cream or a lotion.
6. The cosmetic according to claim 4, wherein the amount of the Chinese medicinal composition added is 0.01-30%.
7. The cosmetic according to claim 6, wherein the amount of the Chinese medicinal composition added is 10-15%.
8. An antioxidant repairing mask, which is characterized in that the effective components of the antioxidant repairing mask are prepared from the traditional Chinese medicine composition of any one of claims 1-3.
9. The antioxidant rejuvenating mask as set forth in claim 8 further including a water phase, an oil phase and adjuvants.
10. The antioxidant rejuvenating mask as set forth in claim 9 wherein said aqueous phase is any one or a combination of at least two of glycerin, hydrogenated lecithin, xanthan gum, acrylic/C10-30 alkanol acrylate crosspolymer, allantoin or panthenol.
11. The antioxidant repair mask of claim 9 wherein the oil phase is any one or a combination of at least two of squalane, dimethicone, isopropyl palmitate, methyl paraben, or propyl paraben.
12. The antioxidant rejuvenating mask as set forth in claim 9 wherein said adjuvant is aminomethyl propanol.
13. An antioxidant moisturizing repair cream, which is characterized in that the effective components of the antioxidant moisturizing repair cream are prepared from the traditional Chinese medicine composition of any one of claims 1-3.
14. The antioxidant moisturizing cream of claim 13, further comprising an aqueous phase, an oil phase, and an adjuvant.
15. The antioxidant moisturizing conditioner of claim 14, wherein the aqueous phase is any one or a combination of at least two of disodium EDTA, panthenol, glycerin, or sodium lecithin/acrylic copolymer.
16. The antioxidant moisturizing conditioner of claim 14, wherein the oil phase is any one or a combination of at least two of squalane, dimethicone, jojoba oil, shea butter, C14-22 alcohol, C12-20 alkyl glucoside, methyl or propyl paraben.
17. The antioxidant moisturizing cream of claim 14, wherein the adjuvant is any one or a combination of at least two of 1, 3-butanediol, β -glucan, aloe barbadensis leaf extract, or aminomethyl propanol.
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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Application publication date: 20190315 Assignee: Guangzhou Novi Biotechnology Co.,Ltd. Assignor: Guangzhou Huanya cosmetics technology Co.,Ltd. Contract record no.: X2024980013201 Denomination of invention: A traditional Chinese medicine composition for repairing blue light damage, its preparation method and use Granted publication date: 20210611 License type: Common License Record date: 20240828 |