CN111671710A

CN111671710A - Blue-light-resistant eye-protecting skin lotion as well as preparation method and use method thereof

Info

Publication number: CN111671710A
Application number: CN202010755923.3A
Authority: CN
Inventors: 肖庆兵; 李金本; 陈帝江
Original assignee: Chongqing Kangshimei Technology Co ltd
Current assignee: Chongqing Kangshimei Technology Co ltd
Priority date: 2020-07-31
Filing date: 2020-07-31
Publication date: 2020-09-18

Abstract

The invention belongs to the technical field of cosmetics, and particularly discloses blue light resisting eye protecting skin lotion which comprises the following raw materials in parts by weight: 50-80 parts of calendula officinalis dry, 10-20 parts of fibronectin, 10-30 parts of aloe vera dry, 4-16 parts of glycerol glucoside and butanediol; the invention also discloses a preparation method and a use method of the blue light resisting eye protecting skin care lotion. The invention can be used as eye drops, can also be used as moisturizing water and spray, and is a blue light-resistant multi-effect eye-protecting and skin-protecting liquid which is initiated for protecting eyes and protecting skin in China.

Description

Blue-light-resistant eye-protecting skin lotion as well as preparation method and use method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to an anti-blue-light eye-protecting skin lotion, and a preparation method and a use method thereof.

Background

Blue light is light with relatively high energy at the wavelength of 400-500 nm, is part of a visible spectrum, can directly penetrate crystals to directly reach the retina, increases the yellow spot zone toxin in the eye, threatens the health of the eye, and can induce cells to generate ROS (reactive oxygen species) to cause damage to dermal stem cells and skin aging.

In daily life, we are almost all around the blue light, and besides the main source of the blue light, such as solar radiation, electronic devices also generate blue light, such as bulbs, computers, mobile phones and televisions, and the blue light has increasingly serious harm to our skin and eyes.

In order to solve the problem of damage of blue light to skin, the Chinese patent application with application publication number CN107789265A discloses a plant extract composition capable of absorbing ultraviolet light and blue light in all bands and application thereof, wherein the plant extract composition comprises 1-40 parts of spinach extract, 1-50 parts of corn stigma extract, 1-50 parts of citrus peel extract, 1-40 parts of calendula extract and 1-50 parts of tomato extract. Although the patent has a strong protection effect, the blue-light-resistant skin care product can only be used as a blue-light-resistant skin care product, and the application range is narrow.

In order to reduce the damage of blue light to eyes, the Chinese patent with the publication number of CN103566068 discloses a compound composition with the function of protecting retina, which comprises the following effective components: 1.00-3.00 wt% of water-soluble lutein, 0.80-1.20 wt% of potassium L-aspartate, 0.1-0.2 wt% of hyaluronic acid, 0.04-0.12 wt% of vitamin B, 0.04-0.07 wt% of vitamin C, 0.04-0.07 wt% of vitamin E, 0.03-0.06 wt% of chamomile extract, 0.03-0.06 wt% of blackcurrant extract, 0.003-0.006 wt% of Morus alba blueberry extract, 0.003-0.006 wt% of eyebright herb powder, 0.003-0.006 wt% of zinc, 0.003-0.006 wt% of calendula officinalis extract, 0.003-0.006 wt% of ginkgo biloba extract, 0.03-0.06 wt% of medlar extract, 0.03-0.06 wt% of anthocyanin and 0.05-0.07 wt% of grape pip. Although the eye fatigue can be effectively relieved and the macular degeneration of the retina can be prevented, the eye fatigue prevention device is single in function, complex in components, easy to cause allergy of patients and poor in popularization.

Disclosure of Invention

The invention aims to provide an anti-blue-light eye-protecting skin-care lotion which can be used as eye drops, moisturizing water and spray, has wide application range, and a preparation method and a use method thereof.

In order to achieve the purpose, the technical scheme of the invention is as follows:

the blue-light-resistant eye-protecting skin lotion comprises the following raw materials in parts by weight: 50-80 parts of calendula officinalis dry, 10-20 parts of fibronectin, 10-30 parts of aloe vera dry, and 4-16 parts of glycerol glucoside and butanediol.

The invention also provides a preparation method of the blue light resisting eye protecting skin moisturizer, which comprises the following steps:

s1, preparing 50-80 parts of dried calendula officinalis with the water content less than or equal to 5%; preparing 10-30 parts of dried aloe leaves with the water content less than or equal to 3%;

s2, extracting the calendula officinalis dry matter and the aloe leaf dry matter obtained in the step S1 by adopting glycerol glucoside and butanediol, wherein the weight part ratio of the glycerol glucoside to the butanediol is 1:1, the weight part sum of the glycerol glucoside and the butanediol is 4-16, the extraction temperature is 60-80 ℃, and the extraction time is 1-4 hours, so that a mixture of a calendula officinalis extracting solution and an aloe vera extracting solution is obtained;

s3, adding fibronectin 10-20 parts into the mixture of the calendula extract and the aloe vera extract, mixing completely, and storing at the temperature below 4 ℃.

The invention also provides a using method of the blue light resisting eye protection skin care lotion, which is used as eye drops, moisturizing water or spray.

The principle and the beneficial effects of the technical scheme are as follows:

(1) compared with the prior art that the eye-protecting skin-care lotion can only be used as an eye-protecting compound composition for resisting blue light or a skin-care product for resisting blue light on the market, the eye-protecting skin-care lotion provided by the technical scheme can be used as eye drops, can also be used as moisturizing water and spray, and is a perfect combination of the anti-blue light multi-effect eye-protecting skin-care lotion which is created for the first time in China and integrates the effects of eye protection and skin care.

(2) Calendula (calendula officinalis L.) also known as marigold, calendula tea, aster ageratoides, water-swollen chrysanthemum and calendula officinalis are herbaceous plants of calendula (calendula officinalis L.) of the Compositae (Asteraceae) for 1 year or 2 years, and are rich in various vitamins, especially vitamin A and vitamin C. Fibronectin, also known as fibronectin, fibronectin and fibronectin, is called fibronectin, a fibronectin in English name, Fn in English name, is mainly generated by liver and vascular endothelial cells, widely exists in animal tissues and tissue fluid, is a macromolecular glycoprotein, and has a dimer molecular weight of about 450 KD. The Aloe Barbadensis Miller extractive solution contains natural anthraquinone glycoside as main effective component.

(3) Tissue repair and wound healing of wounds generally proceeds through three stages, stage one: inflammatory reaction: the wound can start immediately after being injured, usually lasts for 3-5 days, and the stage is mainly used for preventing wound infection and laying a foundation for tissue regeneration and repair; and a second stage: tissue hyperplasia and granulation are formed 24-48 hours after injury; and a third stage: starting 24 hours after injury, lasting up to 1 year, wound contraction, tissue regeneration and plastic phase.

The fibronectin in the technical scheme can prevent wound infection, promote cell growth, improve cell adherence rate, enhance cell metabolism level, shorten cell growth time, and play an important role in the first to third stages of tissue repair and wound healing of wounds; the calendula and the aloe vera in the technical scheme can effectively repair damaged cells, reduce pigmentation caused by a screen, and can effectively moisturize the skin and improve the luster and elasticity of the skin, namely the calendula and the aloe vera play an important role in the second stage and the third stage of tissue repair and wound healing of wounds. In addition, the calendula and the aloe barbadensis in the technical scheme can effectively resist the effects of blue light and ultraviolet rays, protect eyes and facial skin from being damaged by the blue light, prevent red and brown spots of the skin and prevent cell aging.

In conclusion, the technical scheme adopts three main raw materials (calendula, fibronectin and aloe vera), starts to resist blue light and accelerates skin repair from two directions of prevention and repair (tissue repair of wound and stage one to stage three of wound healing). The technical proposal can be directly absorbed by blood vessels around eyes after being used as eye drops (or eye drops) to be dropped into the eyes.

(4) The technical scheme not only simply combines the eye protection product and the skin care product, or only depends on the functions of the calendula, the fibronectin and the aloe vera, and the calendula, the fibronectin and the aloe vera have mutual coordination functions.

Preferably, the mixture of calendula extract and aloe vera extract is prepared using glycerol glucoside and butylene glycol as extraction solvents, the weight ratio of glycerol glucoside to butylene glycol being 1:1 and the sum of glycerol glucoside and butylene glycol being 4-16. The technical scheme has high extraction efficiency on the calendula officinalis dried and the aloe leaf dried, and the prepared blue light-resistant eye-protecting skin lotion has good effect.

Preferably, the water content of the calendula officinalis dried matter is less than or equal to 5%, the water content of the aloe leaf dried matter is less than or equal to 3%, the extraction efficiency of the calendula officinalis dried matter and the aloe leaf dried matter is high, and the prepared anti-blue-light eye-protecting skin lotion is good in effect.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The embodiment provides blue light resisting eye protecting skin lotion which comprises the following raw materials in parts by weight: 50 parts of calendula extract, 10 parts of fibronectin, 10 parts of aloe barbadensis extract and 4 parts of glycerol glucoside and butanediol. The mixture of the calendula extract and the aloe barbadensis extract is prepared by using glycerol glucoside and butanediol as extraction solvents, wherein the weight ratio of the glycerol glucoside to the butanediol is 1: 1. The water content of the calendula officinalis dried product is less than or equal to 5 percent, and the water content of the aloe leaf dried product is less than or equal to 3 percent.

The embodiment also provides a preparation method of the blue-light-resistant eye-protecting skin care lotion, which specifically comprises the following steps:

s1, collecting Marigold in July, collecting dew, rainy day and foggy day, collecting immature or corrosive Marigold, drying the collected Marigold, controlling water content to be less than or equal to 5% to obtain 50 parts of dry Marigold, cleaning fresh folium Aloe, and transversely cutting into 2 × 2-4 × 4cm²Drying the slices, and controlling the water content to be less than or equal to 3% to obtain 10 parts of dried aloe leaves;

s2, extracting the calendula officinalis dry matter and the aloe leaf dry matter obtained in the step S1 by adopting glycerol glucoside and butanediol, wherein the weight part ratio of the glycerol glucoside to the butanediol is 1:1, the weight part sum of the glycerol glucoside and the butanediol is 4-parts, the extraction temperature is 60-80 ℃, and the extraction time is 1-4 hours, so that a mixture of a calendula officinalis extracting solution and an aloe vera extracting solution is obtained;

s3, adding fibronectin 10 parts into the mixture of the calendula extract and the aloe vera extract, fully mixing, and storing at the temperature below 4 ℃.

The embodiment also provides a using method of the blue-light-resistant eye-protecting skin care lotion, which is used as eye drops (or eye drops), moisturizing water or spray.

Examples 2 to 4

Examples 1-4 differ only in that: the raw materials are added in different amounts, and the adding amounts of the examples 1 to 4 are specifically shown in the following table:

example 1 and comparative example 4

Example 1 and comparative example 4 differ only in that: the extraction method of S2 is different, and the specific differences of S3 in example 1 and example 4 are shown in the following table:

and (4) conclusion:

(1) the eye-protecting skin moisturizers prepared in examples 1 to 3 are detected by using a special blue light pen, and the eye-protecting skin moisturizers prepared in examples 1 to 3 can effectively resist over 90% of blue light. Comparative example 1 was only 75% effective against blue light, comparative example 2 was only 83% effective against blue light, comparative example 3 was only 63% effective against blue light, and comparative example 4 was only 82% effective against blue light.

(2) The eye-protecting skin moisturizers prepared in examples 1 to 3 are tested, and the skin moisturizing and moisturizing time of examples 1 to 3 is 2.5 hours, while the skin moisturizing and moisturizing time of comparative example 1 can only reach 0.5 hour, the skin moisturizing and moisturizing time of comparative example 2 can only reach 1.5 hours, the skin moisturizing and moisturizing time of comparative example 3 can only reach 1 hour, and the skin moisturizing and moisturizing time of comparative example 4 can also reach 2.5 hours.

In summary, the technical solutions adopted in examples 1-3 have better blue light resistance than the eye-protecting skin lotion prepared from calendula officinalis and aloe vera (comparative example 2), and better moisturizing effect than the eye-protecting skin lotion prepared from calendula officinalis and aloe vera (comparative example 2), i.e., calendula officinalis, fibronectin and aloe vera have a mutual coordinating effect, rather than simply combining the eye-protecting and skin-protecting products or relying on the own effects of calendula officinalis, fibronectin and aloe vera.

In addition, the technical scheme adopted by the examples 1-3 is the same as that of the comparative example 4 in water replenishing and moisture preserving time, but the examples 1-3 have better blue light resisting effect than the comparative example 4.

Example 4

Compared with the skin care lotion prepared in example 1, the skin care lotion for protecting the eyes against blue light provided in example 4 further comprises 10-30 parts of transforming growth factor and 5-15 parts of murine nerve growth factor, preferably 10-20 parts of transforming growth factor and 5-10 parts of murine nerve growth factor, and more preferably 13 parts of transforming growth factor and 6 parts of murine nerve growth factor.

The preparation method comprises the following steps: mixing the transforming growth factor freeze-dried powder and the rat nerve growth factor freeze-dried powder to obtain a freeze-dried preparation, and storing at the temperature below 4 ℃. An activator having a pH of 4.5-5.0 is formulated with citric acid and 0.9% saline.

The using method comprises the following steps: mixing the lyophilized preparation and activator thoroughly, mixing the mixture of fibronectin and extractive solution of herba Sidae Rhombifoliae prepared from S2 and the extractive solution of Aloe Barbadensis Miller, and making into eye drop, moisturizing water or spray.

And (3) knotting:

(1) the eye-protecting skin moisturizers prepared in examples 1-3 were tested, and it was found that example 4 was effective against over 98% of blue light because: on one hand, the addition of the transforming growth factor and the mouse nerve growth factor can play a synergistic role with calendula extract, fibronectin and aloe barbadensis extract, so that blue light can be resisted more effectively, and on the other hand, the transforming growth factor can strengthen the signal function of ciliary muscle neurons, so that the ciliary muscle neurons are frequently activated by signals, and the spasm and paralysis of the ciliary muscle neurons are relieved; the mouse nerve growth factor shortens the nerve-muscle action potential incubation period, improves the nerve-muscle action potential amplitude and promotes the recovery of injured ciliary muscle neurons. The mouse nerve growth factor can shorten the latency period of ciliary muscle neuron-muscle action potential, improve the action potential amplitude, and promote the ciliary muscle function of myopia persons to recover to normal, thereby treating myopia.

(2) The blue light-resistant eye-protecting skin care lotion provided by the embodiment 4 does not contain preservatives or other additives, does not damage the eye surface and is safer.

(3) In the using process, the transforming growth factor and the mouse nerve growth factor are in a 'latent' state in the freeze-dried preparation of the transforming growth factor and the mouse nerve growth factor, so the transforming growth factor and the mouse nerve growth factor need to be used after being activated by citric acid.

Example 5

Compared with example 4, the blue-light-resistant eye-protecting skin lotion provided in example 5 further comprises 50-80 parts of basic fibroblast growth factor, preferably 60-70 parts of basic fibroblast growth factor, and more preferably 65 parts of basic fibroblast growth factor.

The preparation method comprises the following steps: weighing alkaline fibroblast growth factor freeze-dried powder, and storing at the temperature below 4 ℃.

The using method comprises the following steps: mixing lyophilized preparation and activator, mixing herba Sidae Rhombifoliae extract prepared from basic fibroblast growth factor lyophilized powder, fibronectin and S2 and Aloe Barbadensis extract, and making into eye drop, moisturizing water or spray.

And (3) knotting:

(1) the blue-light-resistant eye-protecting skin care lotion provided by the embodiment can relieve the tense and cramp states of ciliary muscles, promote the ciliary muscles to recover the autonomic accommodation capability and eliminate pseudomyopia caused by ciliary muscle cramp due to overuse of eyes.

The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims

1. The blue-light-resistant eye-protecting skin lotion is characterized by comprising the following raw materials in parts by weight: 50-80 parts of calendula officinalis dry, 10-20 parts of fibronectin, 10-30 parts of aloe vera dry, and 4-16 parts of glycerol glucoside and butanediol.

2. The blue-light-resistant eye-protecting skin-care lotion as claimed in claim 1, wherein the mixture of calendula extract and aloe vera extract is prepared by using glycerol glucoside and butylene glycol as extraction solvents, and the weight ratio of glycerol glucoside to butylene glycol is 1: 1.

3. The blue-light-resistant eye-protecting skin-care lotion as claimed in claim 1 or 2, wherein the moisture content of the calendula officinalis dried powder is less than or equal to 5%, and the moisture content of the aloe barbadensis leaf dried powder is less than or equal to 3%.

4. The method for preparing a blue light-resistant eye-protecting skin lotion according to any one of claims 1-3, which comprises the following steps:

5. The use of a skin care solution for protecting the eyes against blue light according to any one of claims 1 to 4, which is used as eye drops, moisturizing water or spray.