CN108338953B - Plant antioxidant composition and preparation and application of daily chemical thereof - Google Patents
Plant antioxidant composition and preparation and application of daily chemical thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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Abstract
The invention relates to a plant antioxidant composition and preparation and application of daily chemicals thereof. The plant antioxidant composition comprises the following components in parts by weight: 1-40 parts of scutellaria baicalensis decoction pieces, 1-40 parts of white plum blossom decoction pieces, 0.1-20 parts of salvia miltiorrhiza decoction pieces and 0.1-20 parts of cynanchum atratum decoction pieces. The compositions of the invention are all derived from natural antioxidant ingredients. The plant composition has different degrees of scavenging effect on common DPPH free radical and ABTS free radical. Can be used for preparing daily chemical products with the functions of resisting oxidative damage, delaying aging, improving dark yellow skin, relieving fine lines, increasing skin glossiness and the like, and comprises dosage forms of facial masks, essence water, skin care cream, skin care gel, face cleaning lotion, bath lotion and the like, and is used for cleaning and maintaining all parts of the whole body.
Description
The technical field is as follows:
the invention relates to the field of daily chemical products, in particular to a plant antioxidant composition and preparation and application of daily chemical products thereof.
Background art:
the pace of human life has increased at a rapid pace over time, and air pollution has become more and more severe in modern cities. Many people develop a plurality of bad living habits in busy and high-pressure life, so that the skin of more and more people is excessively invaded by free radicals, and a series of skin problems such as darkness, sensitivity, premature aging and the like occur. At present, free radical damage is considered as a main factor of cell aging and pathological changes, and skin is the most damaged human tissues by oxidative stress caused by free radicals due to frequent exposure to oxygen and ultraviolet rays. Among the various free radicals known, the most common are reactive oxygen molecules, which include hydroxyl radicals, hydrogen peroxide, superoxide and monooxygen. Studies have shown that oxygen radicals cause lipid oxidation, resulting in damage to cell membranes, leading to premature aging and ultimately cell death. Meanwhile, most researchers believe that active oxygen can cause ultraviolet-induced damage to the skin, and can also cause acne, wrinkles, age spots, sagging, dryness, and even cancer.
Scavengers of free radicals, known as antioxidants, achieve antioxidant action by inhibiting or terminating the oxygen radical chain reaction. The antioxidant has remarkable preventing and improving effects on skin aging, pathological changes and the like caused by oxidative stress injury of the skin. For example, many superoxide dismutase (SOD), vitamin C, vitamin E, etc. are currently used. However, most of these substances are unstable, and the antioxidant effect of these substances cannot be well exerted. In recent years, with the increasing demand of people for cosmetics to be safe, efficient, non-irritant and the like, the plant antioxidant is increasingly emphasized due to the characteristics of wide sources, safety, effectiveness, nature, no toxicity and the like.
According to experimental research, the scutellaria baicalensis can clear heat, dry dampness, purge fire and detoxify, and has pharmacological effects in various aspects such as free radical elimination, oxidation resistance, cancer resistance, virus resistance, bacteria resistance, allergy resistance, neuron protection and the like; the prunus mume has effects of scavenging oxygen free radicals, preventing melanin deposition, resisting platelet aggregation, resisting depression, etc., and can brighten skin color and make skin become youthful; the red sage root can effectively inhibit skin lipid oxidation, improve local microcirculation, eliminate acnes and color spots caused by unsmooth blood circulation and adjust water-oil balance; radix Cynanchi Atrati has effects of clearing heat, cooling blood, promoting diuresis, treating stranguria, removing toxic substance, treating sore, and has effects of defervescing, resisting inflammation, resisting tumor, resisting oxidation, and improving female climacteric symptom.
In conclusion, with the increase of attention of people to skin care problems, the plant antioxidant composition prepared from the components and the daily chemical products thereof have the advantages of health, high efficiency, environmental protection, high practical value, wide market prospect and the like.
The invention content is as follows:
the invention aims to provide a plant whitening and antioxidant composition and preparation and application of daily chemicals thereof.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention relates to a plant antioxidant composition and a daily chemical thereof, which are characterized by comprising the following components in parts by weight: 1-40 parts of scutellaria baicalensis decoction pieces, 1-40 parts of white plum blossom decoction pieces, 0.1-20 parts of salvia miltiorrhiza decoction pieces and 0.1-20 parts of cynanchum atratum decoction pieces.
The plant antioxidant composition and the daily chemical thereof are characterized in that the extraction method of the composition comprises the following steps:
respectively taking radix Scutellariae, flos Pruni mume, radix Salviae Miltiorrhizae decoction pieces and radix Cynanchi Atrati decoction pieces, mixing, pulverizing, extracting with 20-90% ethanol with a m: V ratio of 3-20 times for 1-3 times, refluxing for 30-180 min each time, mixing extractive solutions, filtering, and concentrating the filtrate for use.
The plant whitening and antioxidant composition and the daily chemical product thereof are characterized in that the weight of the composition used in the daily chemical product is 0.001-10 parts.
The plant antioxidant composition and the daily chemical product thereof are characterized in that the daily chemical product prepared from the composition is a facial mask, an essence, a skin care lotion, a skin care gel, a face cleaning lotion and a body wash, and the facial mask, the essence and the face cleaning lotion are preferred.
The plant antioxidant composition and the daily chemical thereof are characterized in that the preparation method of the facial mask containing the composition comprises the following steps:
the method comprises the following steps: respectively taking 0.1-5 parts by weight of the plant antioxidant composition and 0.001-0.1 part by weight of astaxanthin, adding 0.5-50 parts by weight of diethylene glycol monoethyl ether, 0.1-10 parts by weight of polysorbate-80 and 0.05-5 parts by weight of hydrogenated lecithin, uniformly mixing, adding 0.01-1 part by weight of water-soluble ceramide, 0.01-2 parts by weight of carbomer, 0.01-2 parts by weight of preservative, 0.01-2 parts by weight of essence and a proper amount of water, fully stirring, uniformly mixing and subpackaging to obtain the product.
The second method comprises the following steps: respectively taking 0.001-0.1 part of plant antioxidant composition, 0.001-0.1 part of astaxanthin and 0.001-0.1 part of coenzyme Q10 by weight, adding 0.5-50 parts of diethylene glycol monoethyl ether, 0.1-10 parts of polysorbate-80 and 0.05-5 parts of hydrogenated lecithin, uniformly mixing, adding 0.01-10 parts of dendrobium devoninum paxt extract, 0.01-10 parts of ganoderma lucidum extract, 0.01-2 parts of xanthan gum, 0.01-5 parts of preservative, 0.01-2 parts of essence and a proper amount of water, fully stirring, uniformly mixing and subpackaging to obtain the composition.
The third method comprises the following steps: respectively taking 0.1-10 parts by weight of isododecane, 0.1-5 parts by weight of diisostearyl malate, 0.02-2 parts by weight of polydimethylsiloxane, 0.02-2 parts by weight of polymethylsilsesquioxane, 0.001-0.1 part by weight of astaxanthin, 0.1-5 parts by weight of ethylene glycol distearate and 0.1-10 parts by weight of shea butter, heating and mixing uniformly, adding 0.1-5 parts by weight of plant antioxidant composition, 0.5-5 parts by weight of diethylene glycol monoethyl ether and 0.2-2 parts by weight of polysorbate-80, heating and mixing uniformly, then adding 0.001-0.1 part by weight of proline, 0.001-0.1 part by weight of arginine, 0.001-0.1 part by weight of valine, 0.001-0.1 part by weight of threonine, 0.001-1 part by weight of sodium hyaluronate, 0.5-5 parts by weight of propylene glycol, 0.1-10 parts by weight of glycerol monostearate, 0.1-10 parts of polyglycerol-3 distearate, 0.1-10 parts of glycerol polyethylene glycol-75-stearate, 0.01-5 parts of preservative, 0.01-2 parts of essence and a proper amount of water, keeping the temperature of 60-100 ℃, homogenizing and emulsifying for 5-60 minutes, cooling and filling to obtain the finished product.
The plant antioxidant composition and the daily chemical thereof are characterized in that the preparation method of the essence containing the composition comprises the following steps:
the method comprises the following steps: respectively taking 0.1-10 parts by weight of plant antioxidant composition, 0.001-0.1 part by weight of astaxanthin and 0.001-0.1 part by weight of coenzyme Q10, adding 0.5-50 parts by weight of diethylene glycol monoethyl ether, 0.1-10 parts by weight of polysorbate-80 and 0.05-5 parts by weight of hydrogenated lecithin, uniformly mixing, adding 0.001-0.1 part by weight of proline, 0.001-0.1 part by weight of arginine, 0.001-0.1 part by weight of valine, 0.001-0.1 part by weight of threonine, 0.02-0.2 part by weight of polyacrylamide, 0.01-2 parts by weight of preservative, 0.01-2 parts by weight of essence and a proper amount of water, fully stirring, uniformly mixing and filling to obtain the product.
The second method comprises the following steps: respectively taking 0.1-10 parts by weight of plant antioxidant composition, 0.001-0.1 part by weight of astaxanthin and 0.001-0.1 part by weight of coenzyme Q10, adding 0.5-50 parts by weight of diethylene glycol monoethyl ether, 0.1-10 parts by weight of polysorbate-80, 0.05-5 parts by weight of hydrogenated lecithin, 0.01-1 part by weight of shea butter and 0.01-5 parts by weight of oleic acid polyethylene glycol glyceride, uniformly mixing, adding 0.001-0.1 part by weight of proline, 0.001-0.1 part by weight of arginine, 0.001-0.1 part by weight of valine, 0.001-0.1 part by weight of threonine, 0.01-10 parts by weight of PEG-40 hydrogenated castor oil, 0.01-2 parts by weight of preservative, 0.01-2 parts by weight of essence and a proper amount of water, fully stirring and uniformly mixing, mixing with nitrogen at a low temperature, and filling to obtain the product.
The plant antioxidant composition and the daily chemical thereof are characterized in that the preparation method of the facial cleanser containing the composition comprises the following steps:
respectively taking 1-30 parts of myristic acid, lauric acid and stearic acid and 0.5-20 parts of glycerin, heating to melt, adding 1-30 parts of potassium hydroxide, and stirring at 30-90 ℃ for 5-180 min. Adding 0.001-0.1 part of plant antioxidant composition, 1-10 parts of propylene glycol and 0.1-10 parts of polysorbate-80, heating and mixing, stirring uniformly, adding 0.5-10 parts of cocamide betaine, 0.5-10 parts of disodium cocoyl amphodiacetate, 0.5-10 parts of isopropyl palmitate, 0.1-20 parts of diisostearyl malate, 0.5-10 parts of glyceryl monostearate, 0.5-10 parts of cetearyl glucoside, 0.01-3 parts of polyquaternium-39, 0.01-2 parts of preservative, 0.01-3 parts of essence and appropriate amount of water, keeping warm, mixing, cooling and filling to obtain the product.
The plant antioxidant composition and the daily chemical thereof are characterized in that the plant antioxidant composition has different degrees of scavenging effects on common DPPH free radicals and ABTS free radicals. Has effects in resisting oxidative damage, delaying aging, improving skin dark yellow, relieving fine wrinkles, and improving skin glossiness, and is suitable for cleaning and maintaining various parts of the whole body.
The specific implementation mode is as follows:
the embodiments of the present invention will be described in detail with reference to the following examples, which should be construed as merely illustrative and not a limitation of the technical aspects of the present invention, and although the present invention is described in detail with reference to the following examples, it should be understood by those skilled in the art that the present invention can be modified or substituted with equivalents without departing from the spirit and scope of the present invention, and the modifications or partial substitutions should be covered by the claims of the present invention.
The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Example 1:
an essence facial mask of a plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 20 parts by weight of scutellaria baicalensis, 40 parts by weight of prunus mume, 20 parts by weight of salvia miltiorrhiza and 0.1 part by weight of cynanchum atratum, mixing and crushing, adding 50% ethanol, refluxing and extracting for 2 times, adding 8 times of solvent each time, refluxing for 120 minutes, combining extracting solutions, filtering, concentrating filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 50% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 0.1 part by weight of the plant antioxidant composition and 0.001 part by weight of astaxanthin, adding 0.5 part by weight of diethylene glycol monoethyl ether, 1 part by weight of polysorbate-80 and 5 parts by weight of hydrogenated lecithin, uniformly mixing, adding 0.01 part by weight of water-soluble ceramide, 0.3 part by weight of carbomer, 0.05 part by weight of preservative, 0.01 part by weight of essence and a proper amount of water, fully stirring, uniformly mixing, and subpackaging to obtain the finished product.
Example 2:
a facial mask liquid of a plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 40 parts by weight of scutellaria baicalensis, 20 parts by weight of prunus mume, 0.1 part by weight of salvia miltiorrhiza decoction pieces and 20 parts by weight of cynanchum atratum decoction pieces, mixing and crushing, adding 20% ethanol, refluxing and extracting for 3 times, adding 3 times of solvent each time, refluxing for 180 minutes, combining extracting solutions, filtering, and concentrating the filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 20% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 0.001 part by weight of the plant antioxidant composition, 0.1 part by weight of astaxanthin and 0.1 part by weight of coenzyme Q10, adding 25 parts by weight of diethylene glycol monoethyl ether, 8 parts by weight of polysorbate-80 and 0.05 part by weight of hydrogenated lecithin, uniformly mixing, adding 10 parts by weight of dendrobium devoninum paxt extract, 10 parts by weight of ganoderma lucidum extract, 0.3 part by weight of xanthan gum, 1 part by weight of preservative, 0.06 part by weight of essence and a proper amount of water, fully stirring and uniformly mixing, and subpackaging to obtain the finished product.
Example 3:
a sleep facial mask containing plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 1 part by weight of scutellaria baicalensis, 40 parts by weight of prunus mume, 20 parts by weight of salvia miltiorrhiza and 20 parts by weight of cynanchum atratum, mixing and crushing, adding 70% ethanol, refluxing and extracting for 2 times, adding 15 times of solvent each time, refluxing for 60 minutes, combining extracting solutions, filtering, and concentrating the filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 70% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 2 parts by weight of isododecane, 2 parts by weight of diisostearyl malate, 0.5 part by weight of polydimethylsiloxane, 0.5 part by weight of polymethylsilsesquioxane, 0.01 part by weight of astaxanthin, 1 part by weight of ethylene glycol distearate and 10 parts by weight of shea butter, heating and uniformly mixing, adding a mixed solution of 2 parts by weight of the plant antioxidant composition, 5 parts by weight of diethylene glycol monoethyl ether and 2 parts by weight of polysorbate-80, heating and uniformly mixing, adding 0.1 part by weight of proline, 0.1 part by weight of arginine, 0.1 part by weight of valine, 0.1 part by weight of threonine, 0.001 part by weight of sodium hyaluronate, 5 parts by weight of propylene glycol, 10 parts by weight of glyceryl monostearate, 10 parts by weight of polyglycerol-3 distearate, 5 parts by weight of glycerol polyethylene glycol-75-stearate, 0.5 part by weight of preservative, 1 part by weight of essence and an appropriate amount of water, keeping the temperature of the mixture to be homogenized and emulsified for 45 minutes, cooling, and packaging.
Example 4:
a skin care lotion of plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 40 parts by weight of scutellaria baicalensis, 1 part by weight of prunus mume, 20 parts by weight of salvia miltiorrhiza and 20 parts by weight of cynanchum atratum, mixing and crushing, adding 90% ethanol, refluxing and extracting for 1 time, adding 20 times of solvent each time, refluxing for 30 minutes, combining extracting solutions, filtering, and concentrating filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 90% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 0.01 part by weight of plant antioxidant composition, 0.001 part by weight of astaxanthin and 0.001 part by weight of coenzyme Q10, adding 10 parts by weight of diethylene glycol monoethyl ether, 1 part by weight of polysorbate-80 and 0.5 part by weight of hydrogenated lecithin, uniformly mixing, adding 0.001 part by weight of proline, 0.001 part by weight of arginine, 0.001 part by weight of valine, 0.001 part by weight of threonine, 0.2 part by weight of polyacrylamide, 0.2 part by weight of preservative, 0.3 part by weight of essence and a proper amount of water, fully stirring, uniformly mixing, and filling to obtain the product.
Example 5:
an essence spray of a plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 20 parts by weight of scutellaria baicalensis, 20 parts by weight of prunus mume, 10 parts by weight of salvia miltiorrhiza and 10 parts by weight of cynanchum atratum, mixing and crushing, adding 60% ethanol, refluxing and extracting for 2 times, adding 10 times of solvent each time, refluxing for 90 minutes, combining extracting solutions, filtering, and concentrating the filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 60% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 10 parts by weight of plant antioxidant composition, 0.01 part by weight of astaxanthin and 0.01 part by weight of coenzyme Q10, adding 30 parts by weight of diethylene glycol monoethyl ether, 5 parts by weight of polysorbate-80, 2 parts by weight of hydrogenated lecithin, 0.05 part by weight of shea butter and 2 parts by weight of oleic acid polyethylene glycol glyceride, uniformly mixing, adding 0.01 part by weight of proline, 0.01 part by weight of arginine, 0.01 part by weight of valine, 0.01 part by weight of threonine, 1 part by weight of PEG-40 hydrogenated castor oil, 0.05 part by weight of preservative, 0.1 part by weight of essence and a proper amount of water, fully stirring and uniformly mixing, mixing nitrogen at a low temperature, and filling to obtain the product.
Example 6:
a facial cleanser containing plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 30 parts by weight of scutellaria baicalensis, 30 parts by weight of prunus mume, 5 parts by weight of salvia miltiorrhiza and 5 parts by weight of cynanchum atratum, mixing and crushing, adding 40% ethanol, refluxing and extracting for 3 times, adding 6 times of solvent each time, refluxing for 150 minutes, combining extracting solutions, filtering, and concentrating filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 40% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 10 parts of myristic acid, lauric acid and stearic acid and 15 parts of glycerin, heating to melt, adding 8 parts of potassium hydroxide, and stirring at 60 ℃ for 90 min. Adding 0.05 part of plant antioxidant composition, 5 parts of propylene glycol and 0.5 part of polysorbate-80, heating and mixing, stirring uniformly, adding 5 parts of cocamidobetaine, 5 parts of disodium cocoamphodiacetate, 5 parts of isopropyl palmitate, 5 parts of diisostearyl malate, 5 parts of glyceryl monostearate, 5 parts of cetearyl glucoside, 0.5 part of polyquaternium-39, 0.02 part of preservative, 1 part of essence and proper amount of water, keeping warm, mixing, cooling and filling to obtain the product.
Example 7:
a facial mask liquid of a plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 1 part by weight of scutellaria baicalensis, 40 parts by weight of prunus mume, 20 parts by weight of salvia miltiorrhiza and 20 parts by weight of cynanchum atratum, mixing and crushing, adding 70% ethanol, refluxing and extracting for 2 times, adding 15 times of solvent each time, refluxing for 60 minutes, combining extracting solutions, filtering, and concentrating the filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 70% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 5 parts by weight of the plant antioxidant composition, 0.001 part by weight of astaxanthin, 0.001 part by weight of coenzyme Q10, adding 30 parts by weight of diethylene glycol monoethyl ether, 5 parts by weight of polysorbate-80 and 0.05 part by weight of hydrogenated lecithin, uniformly mixing, adding 0.01 part by weight of dendrobium devoninum paxt extract, 0.01 part by weight of ganoderma extract, 0.1 part by weight of xanthan gum, 1 part by weight of preservative, 0.06 part by weight of essence and a proper amount of water, fully stirring and uniformly mixing, and subpackaging to obtain the finished product.
Example 8:
a washing-free facial mask of plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 30 parts by weight of scutellaria baicalensis, 30 parts by weight of prunus mume, 5 parts by weight of salvia miltiorrhiza and 5 parts by weight of cynanchum atratum, mixing and crushing, adding 40% ethanol, refluxing and extracting for 3 times, adding 6 times of solvent each time, refluxing for 150 minutes, combining extracting solutions, filtering, and concentrating filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 40% ethanol, mixing eluates, and drying.
2. Preparation:
0.5 part of isododecane, 0.5 part of diisostearyl malate, 1 part of polydimethylsiloxane, 0.1 part of polymethylsilsesquioxane, 0.1 part of astaxanthin, 0.9 part of ethylene glycol distearate and 0.1 part of shea butter are taken respectively, the mixture is heated and mixed uniformly, 1 part of plant antioxidant composition, 1 part of diethylene glycol monoethyl ether and 0.5 part of polysorbate-80 are added, the mixture is heated and mixed uniformly, 0.01 part of proline, 0.01 part of arginine, 0.01 part of valine, 0.01 part of threonine, 1 part of sodium hyaluronate, 0.5 part of propylene glycol, 1 part of glycerol monostearate, 5 parts of polyglycerol-3 distearate, 10 parts of glycerol polyethylene glycol-75-stearate, 0.1 part of preservative, 0.1 part of essence and a proper amount of water are added, the mixture is kept for emulsification at 75 ℃ and homogenization is carried out for 60 minutes, cooling, and packaging.
Example 9:
a facial mask liquid of a plant antioxidant composition is prepared by the following steps:
1. extraction:
respectively taking 20 parts by weight of scutellaria baicalensis, 40 parts by weight of prunus mume, 20 parts by weight of salvia miltiorrhiza and 0.1 part by weight of cynanchum atratum, mixing and crushing, adding 50% ethanol, refluxing and extracting for 2 times, adding 8 times of solvent each time, refluxing for 120 minutes, combining extracting solutions, filtering, concentrating filtrate for later use.
Passing the concentrated solution through macroporous resin column, eluting with 50% ethanol, mixing eluates, and drying.
2. Preparation:
respectively taking 0.1 part by weight of the plant antioxidant composition and 0.1 part by weight of astaxanthin, adding 10 parts by weight of diethylene glycol monoethyl ether, 0.5 part by weight of polysorbate-80 and 1 part by weight of hydrogenated lecithin, uniformly mixing, adding 1 part by weight of water-soluble ceramide, 0.6 part by weight of carbomer, 0.1 part by weight of preservative, 0.1 part by weight of essence and a proper amount of water, fully stirring, uniformly mixing, and subpackaging to obtain the plant antioxidant composition.
Example 10:
DPPH free radical scavenging and ABTS free radical scavenging experiments for a plant antioxidant composition:
1. the experimental method comprises the following steps:
1.1DPPH radical scavenging experiment
The experiment was performed by absorptiometry. The samples were added to a 96-well plate, 3 replicate wells were set, 2 dilution gradients per sample, 10-fold dilution was performed (4 dilution gradients per sample after primary screening if the samples had significant DPPH free radical scavenging effect, 2-fold dilution was performed for replicate wells), 100 μ L per well, 0.1M DPPH 100 μ L per well. The negative control used 50% ethanol instead of sample, and the blank used 50% ethanol instead of DPPH, and the rest of the procedure was the same. The reaction solution was mixed well and incubated for 30 minutes at room temperature in the dark. And reading the absorbance value at 517nm by using a microplate reader, wherein the lower the delta OD value is, the higher the scavenging activity of the sample on free radicals is. Calculation of DPPH radical scavenging Rate and IC50。
1.2 ABTS free radical scavenging experiments
The experiment was performed by absorptiometry. Adding samples into a 96-well plate, setting 3 repeated wells, diluting each sample by 2 dilution gradients, performing 10-fold dilution (after preliminary screening, if the samples have obvious ABTS free radical scavenging effect, each sample has 4 dilution gradients, performing 2-fold dilution, performing secondary screening), each well has 100 μ L,100 μ L of 0.1M ABTS was added to each well. The negative control uses 50% ethanol instead of sample, the blank uses 50% ethanol instead of ABTS, and the rest of the procedure is the same. The reaction solution was mixed well and incubated for 30 minutes at room temperature in the dark. The absorbance light value of 734nm is read by a microplate reader, and the lower the value of the delta OD value is, the higher the scavenging activity of the sample to free radicals is. Calculation of ABTS free radical clearance and IC50。
2. Experimental materials:
trolox (Sigma, cat # 238813-1G, lot # BCBP2767V), DPPH (Sigma, cat # D9132-1G, lot # STBF52 5255V), ABTS (Sigma, cat # A1888-1G, lot # SLBN7932V), K2S2O8(Sigma, cat # P112194-25G, lot # F1508005), sodium dihydrogen phosphate (Sjogren Kagaku K.K.: 1202011), disodium hydrogen phosphate (Sjogren Kagaku K.K.: 111021), absolute ethanol (Rianlongbo (Tianjin) pharmaceutical Co., Ltd.: D4540-100ML, lot # 20150205), DMSO (volume fraction of DMSO in the final reaction system)<1 percent), Multiskan GO enzyme-linked immunosorbent assay (Thermo), PRACTUM224-1CN electronic balance (Satorius), GNP-9270 water-proof constant-temperature incubator (Shanghai sperm macroexperimental equipment Co., Ltd.), 30-300 mu L of discharge gun (Thermo Co., Ltd.), and liquid-transfering gun (Dalong Co., Ltd.) with various measuring ranges.
3. The experimental results are as follows:
table 1: table of results of effect of eliminating DPPH free radical and ABTS free radical
The results show that 1% DMSO (vehicle control) had no significant effect on the assay system; DPPH self of Trolox (positive control)Radical scavenging IC506.97 μ g/mL, ABTS free radical scavenging IC507.77 mu g/mL; (ii) a The scutellaria baicalensis, the prunus mume, the salvia miltiorrhiza and the cynanchum atratum have the effects of resisting DPPH free radicals and ABTS free radicals when being used independently; after the 4 medicinal materials are mixed and refined to form the composition, the effects of resisting DPPH free radicals and ABTS free radicals are obviously improved, and the prepared related preparation still has the effect of scavenging the free radicals.
Claims (1)
1. The daily chemical product containing the plant antioxidant composition is characterized in that the plant antioxidant composition is composed of the following components in parts by weight: 1-40 parts of scutellaria baicalensis decoction pieces, 1-40 parts of white plum blossom decoction pieces, 0.1-20 parts of salvia miltiorrhiza decoction pieces and 0.1-20 parts of cynanchum atratum decoction pieces;
the extraction method of the plant antioxidant composition comprises the following steps:
mixing and crushing scutellaria baicalensis, prunus mume, salvia miltiorrhiza decoction pieces and cynanchum atratum decoction pieces respectively, adding 20-90% ethanol with the m: V ratio of 3-20 times, performing reflux extraction for 1-3 times, performing 30-180 minutes each time, combining extracting solutions, filtering, and concentrating filtrate for later use;
secondly, passing the concentrated solution through a macroporous resin column, eluting with 20-90% ethanol, mixing the eluates, and drying to obtain the extract;
the daily chemical products are facial masks, essence and facial cleanser;
the preparation method of the facial mask containing the composition comprises the following steps:
the method comprises the following steps: respectively taking 0.1-5 parts by weight of the plant antioxidant composition and 0.001-0.1 part by weight of astaxanthin, adding 0.5-50 parts by weight of diethylene glycol monoethyl ether, 0.1-10 parts by weight of polysorbate-80 and 0.05-5 parts by weight of hydrogenated lecithin, uniformly mixing, adding 0.01-1 part by weight of water-soluble ceramide, 0.01-2 parts by weight of carbomer, 0.01-2 parts by weight of preservative, 0.01-2 parts by weight of essence and a proper amount of water, fully stirring, uniformly mixing and subpackaging to obtain the composition;
the second method comprises the following steps: respectively taking 0.001-0.1 part by weight of plant antioxidant composition, 0.001-0.1 part by weight of astaxanthin and 0.001-0.1 part by weight of coenzyme Q10, adding 0.5-50 parts by weight of diethylene glycol monoethyl ether, 0.1-10 parts by weight of polysorbate-80 and 0.05-5 parts by weight of hydrogenated lecithin, uniformly mixing, adding 0.01-10 parts by weight of dendrobium devoninum paxt extract, 0.01-10 parts by weight of ganoderma lucidum extract, 0.01-2 parts by weight of xanthan gum, 0.01-5 parts by weight of preservative, 0.01-2 parts by weight of essence and a proper amount of water, fully stirring, uniformly mixing and subpackaging to obtain the composition;
the third method comprises the following steps: respectively taking 0.1-10 parts by weight of isododecane, 0.1-5 parts by weight of diisostearyl malate, 0.02-2 parts by weight of polydimethylsiloxane, 0.02-2 parts by weight of polymethylsilsesquioxane, 0.001-0.1 part by weight of astaxanthin, 0.1-5 parts by weight of ethylene glycol distearate and 0.1-10 parts by weight of shea butter, heating and mixing uniformly, adding 0.1-5 parts by weight of plant antioxidant composition, 0.5-5 parts by weight of diethylene glycol monoethyl ether and 0.2-2 parts by weight of polysorbate-80, heating and mixing uniformly, then adding 0.001-0.1 part by weight of proline, 0.001-0.1 part by weight of arginine, 0.001-0.1 part by weight of valine, 0.001-0.1 part by weight of threonine, 0.001-1 part by weight of sodium hyaluronate, 0.5-5 parts by weight of propylene glycol, 0.1-10 parts by weight of glycerol monostearate, 0.1-10 parts of polyglycerol-3 distearate, 0.1-10 parts of glycerol polyethylene glycol-75-stearate, 0.01-5 parts of preservative, 0.01-2 parts of essence and a proper amount of water, keeping the temperature of 60-100 ℃, homogenizing and emulsifying for 5-60 minutes, cooling and filling to obtain the product;
the preparation method of the essence containing the composition comprises the following steps:
the method comprises the following steps: respectively taking 0.1-10 parts by weight of plant antioxidant composition, 0.001-0.1 part by weight of astaxanthin and 0.001-0.1 part by weight of coenzyme Q10, adding 0.5-50 parts by weight of diethylene glycol monoethyl ether, 0.1-10 parts by weight of polysorbate-80 and 0.05-5 parts by weight of hydrogenated lecithin, uniformly mixing, adding 0.001-0.1 part by weight of proline, 0.001-0.1 part by weight of arginine, 0.001-0.1 part by weight of valine, 0.001-0.1 part by weight of threonine, 0.02-0.2 part by weight of polyacrylamide, 0.01-2 parts by weight of preservative, 0.01-2 parts by weight of essence and a proper amount of water, fully stirring, uniformly mixing and filling to obtain the product;
the second method comprises the following steps: respectively taking 0.1-10 parts by weight of plant antioxidant composition, 0.001-0.1 part by weight of astaxanthin and 0.001-0.1 part by weight of coenzyme Q10, adding 0.5-50 parts by weight of diethylene glycol monoethyl ether, 0.1-10 parts by weight of polysorbate-80, 0.05-5 parts by weight of hydrogenated lecithin, 0.01-1 part by weight of shea butter and 0.01-5 parts by weight of oleic acid polyethylene glycol glyceride, uniformly mixing, adding 0.001-0.1 part by weight of proline, 0.001-0.1 part by weight of arginine, 0.001-0.1 part by weight of valine, 0.001-0.1 part by weight of threonine, 0.01-10 parts by weight of PEG-40 hydrogenated castor oil, 0.01-2 parts by weight of preservative, 0.01-2 parts by weight of essence and a proper amount of water, fully stirring and uniformly mixing, mixing with nitrogen at a low temperature, and filling to obtain the product;
the preparation method of the facial cleanser containing the composition comprises the following steps:
respectively taking 1-30 parts of myristic acid, lauric acid and stearic acid and 0.5-20 parts of glycerin, heating to melt, adding 1-30 parts of potassium hydroxide, and stirring at 30-90 ℃ for 5-180 min; adding 0.001-0.1 part of plant antioxidant composition, 1-10 parts of propylene glycol and 0.1-10 parts of polysorbate-80, heating and mixing, stirring uniformly, adding 0.5-10 parts of cocamide betaine, 0.5-10 parts of disodium cocoyl amphodiacetate, 0.5-10 parts of isopropyl palmitate, 0.1-20 parts of diisostearyl malate, 0.5-10 parts of glyceryl monostearate, 0.5-10 parts of cetearyl glucoside, 0.01-3 parts of polyquaternium-39, 0.01-2 parts of preservative, 0.01-3 parts of essence and appropriate amount of water, keeping warm, mixing, cooling and filling to obtain the product.
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Application publication date: 20180731 Assignee: Yunnan Baiyao Group Co.,Ltd. Assignor: YUNNAN INSTITUTE OF MATERIA MEDICA Contract record no.: X2022530000005 Denomination of invention: A plant antioxidant composition and its preparation and application of daily chemicals Granted publication date: 20210312 License type: Common License Record date: 20220624 |