CN110074985B - Binary spray for resisting damage of blue light to skin and preparation method thereof - Google Patents
Binary spray for resisting damage of blue light to skin and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention belongs to the technical field of cosmetics, and provides a binary spray for resisting damage of blue light to skin and a preparation method thereof, wherein the binary spray comprises an A phase, a B phase and a C phase, wherein the A phase comprises the following components: water, betaine, EDTA disodium, beta-glucan, hyaluronic acid, glycerol, butanediol, 1, 2-hexanediol, and p-hydroxyacetophenone; the phase B consists of the following components: tocopheryl acetate, PEG-40 hydrogenated castor oil, PPG-30 cetyl ether; phase C consists of the following components: PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, and water-based coated cerium oxide. Through above-mentioned technical scheme, the problem that skin care products resist blue light effect not good among the prior art has been solved.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and relates to a binary spray for resisting damage of blue light to skin and a preparation method thereof.
Background
Short-wave blue light refers to light waves with the wavelength between 400nm and 450 nm. This band is also called high-energy short-wave blue light because of its relatively high energy due to its short wavelength. Blue light of this wavelength is able to penetrate the lens of the eye through to the retina, causing atrophy and even death of the retinal epithelial cells, which directly leads to a reduction or even complete loss of vision. Blue light can also cause macular degeneration. The lens in human eyes absorbs part of blue light and gradually becomes turbid to form cataract, most of the blue light penetrates through the lens, especially the lens of children is clear and cannot effectively resist the blue light, and therefore macular degeneration and cataract are easily caused. In addition to the eye, short-wave blue light also causes irreversible damage to the skin. Research shows that short-wave blue light can penetrate skin, promote the generation of active oxygen, destroy cell membranes, increase skin melanin, and cause pigmentation, stains, freckles, dullness, skin aging and other problems. Therefore, protection against blue light is an indispensable part of daily skin care.
Cerium oxide is used in a wide variety of applications, and is widely used in the fields of building materials, glass, agriculture, and the like. For example, the rare earth polishing powder has the advantages of high polishing speed, high smoothness, long service life and the like; simultaneously, the glass is also used for decoloring or coloring glass; in addition, the ultraviolet ray transmittance reducing agent is also applied to automobile glass, crystal glass and the like, and can reduce the ultraviolet ray transmittance. Since cerium is a rare earth metal, cerium oxide is difficult to disperse in water, resulting in its not being widely used in the cosmetic field.
Disclosure of Invention
The invention provides a binary spray for resisting the damage of blue light to skin and a preparation method thereof, and solves the problem that skin care products in the prior art are poor in blue light resisting effect.
The technical scheme of the invention is realized as follows:
a binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: comprises an A phase, a B phase and a C phase,
the phase A consists of the following components:
water, betaine, EDTA disodium, beta-glucan, hyaluronic acid, glycerol, butanediol, 1, 2-hexanediol, and p-hydroxyacetophenone;
the phase B consists of the following components:
tocopheryl acetate, PEG-40 hydrogenated castor oil, PPG-30 cetyl ether;
the phase C consists of the following components:
PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, and water-based coated cerium oxide.
As a further technical scheme, the phase A consists of the following components in parts by weight:
75.3-97.158 parts of water, 0.5-5 parts of betaine, 0.01-0.2 part of EDTA disodium, 0.001-0.1 part of beta-glucan, 0.001-0.4 part of hyaluronic acid, 0.5-2 parts of glycerol, 0.5-6 parts of butanediol, 0.1-1 part of 1, 2-hexanediol and 0.1-1 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.01-0.2 part of tocopherol acetate, 0.01-0.4 part of PEG-40 hydrogenated castor oil and 0.01-0.4 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.1-2 parts of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 1-6 parts of water-based coating cerium oxide.
As a further technical scheme, the phase A consists of the following components in parts by weight:
79.19-86.389 parts of water, 2-3 parts of betaine, 0.01-0.05 part of EDTA disodium, 0.001-0.01 part of beta-glucan, 0.05-0.1 part of hyaluronic acid, 2-3 parts of glycerol, 4-6 parts of butanediol, 0.4-0.6 part of 1, 2-hexanediol and 0.4-0.6 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.05-0.15 part of tocopherol acetate, 0.15-0.25 part of PEG-40 hydrogenated castor oil and 0.15-0.25 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.4-0.6 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 4-6 parts of water-based coating cerium oxide.
As a further technical scheme, the phase A consists of the following components in parts by weight:
84.372 parts of water, 1.5 parts of betaine, 0.02 part of EDTA disodium, 0.008 part of beta-glucan, 0.1 part of hyaluronic acid, 1.5 parts of glycerol, 5.5 parts of butanediol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.1 part of tocopherol acetate, 0.2 part of PEG-40 hydrogenated castor oil and 0.2 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.5 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 5 parts of aqueous coating cerium oxide.
As a further technical scheme, the aqueous coating cerium oxide consists of the following components in parts by weight:
46 parts of poloxamer and 5 parts of cerium oxide.
A binary spray for protecting skin from blue light damage, wherein the cerium oxide comprises cerium oxide which absorbs blue light in a waveband of 400-450 nm and is sold under the trade name of AQUACERIA cerium oxide.
The invention also provides a preparation method of the binary spray for resisting the damage of blue light to the skin, which comprises the following steps:
s1, weighing raw materials of all phases according to the formula of the binary spray for resisting the damage of blue light to skin for later use;
s2, stirring the phase A raw material, heating to 86-88 ℃, and homogenizing and dispersing uniformly;
s3, cooling the phase A raw material obtained in the step S2 to 45 ℃, adding the phase B raw material, and uniformly stirring to obtain a primary mixed material;
and S4, adding the phase C into the primary mixed material obtained in the step S3, and uniformly stirring to obtain the binary spray for resisting the damage of blue light to the skin.
As a further technical scheme, the stirring speed in the step S2 is 600-800 r/min.
As a further technical scheme, the step S2 of homogenizing is specifically homogenizing for 1-3 min at a speed of 1500-2500 r/min.
As a further technical scheme, the stirring speed in the step S3 is 600-800 r/min.
As a further technical scheme, the stirring in the step S4 is specifically stirring for 5-20 min at a rotating speed of 600-800 r/min.
The working principle and the beneficial effects of the invention are as follows:
1. according to the invention, the binary spray is prepared from phase A, phase B and phase C raw materials, and the raw materials of the phases are matched with each other in the formula, so that the prepared binary spray has good moisturizing and whitening effects, effectively reduces the melanin content of the skin, has a good eliminating effect on active oxygen generated by blue light induction, effectively resists the damage of blue light to the skin, and well solves the problem that a skin care product in the prior art has a poor blue light resisting effect.
2. Cerium oxide has a strong reflection effect on ultraviolet light and short-wave blue light, has a proper forbidden bandwidth, can absorb light energy of 280-450nm, and the absorbed light energy is mainly used for transition of an electronic energy level and is released by heat and light with lower energy, so that the cerium oxide has double effects of reflecting, absorbing ultraviolet light and short-wave blue light. In the invention, cerium oxide is assembled in poloxamer to prepare aqueous cerium oxide, and then the aqueous cerium oxide is added into binary spray, and the aqueous cerium oxide is compatible with other phase components in a formula, so that the blue light resistant effect of the cerium oxide can be fully exerted, the prepared binary spray can effectively resist the damage of blue light to skin, and the technical problem that the cerium oxide is difficult to disperse in water and cannot exert the effect in the binary spray in the prior art is well solved.
3. According to the invention, betaine, disodium EDTA, beta-glucan and hyaluronic acid in the binary spray phase A raw material are compatible with each other, so that after the binary spray is sprayed to the skin, a layer of protective film is formed on the surface layer of the cell, the original nutrition and moisture of the skin are kept, skin cells are nourished, and the water replenishing and moisturizing capability of the binary spray is improved.
4. According to the invention, the tocopherol acetate in the binary spray B phase raw material is matched with PPG-30 cetyl ether, so that a good synergistic effect is achieved on the moisturizing effect of the binary spray, the prepared binary spray has a good nourishing and moistening effect on skin, the skin moisture is kept, the skin touch is soft, meanwhile, the tocopherol acetate also has a good antioxidation effect, and the effect of the binary spray being lower than that of blue light is improved by matching with cerium oxide, so that the prepared binary spray not only can effectively resist the damage of the blue light to the skin, but also has a good moisturizing effect, and is suitable for popularization and use.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
75.3 parts of water, 0.5 part of betaine, 0.01 part of EDTA disodium, 0.001 part of beta-glucan, 0.001 part of hyaluronic acid, 0.5 part of glycerol, 0.5 part of butanediol, 0.1 part of 1, 2-hexanediol and 0.1 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.01 part of tocopherol acetate, 0.01 part of PEG-40 hydrogenated castor oil and 0.01 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.1 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 1 part of aqueous coating cerium oxide;
the preparation method comprises the following steps:
s1, weighing raw materials of all phases according to the formula for later use;
s2, mixing the phase A raw materials, stirring at a speed of 600-800 r/min, heating to 86-88 ℃, homogenizing at a speed of 1500-2500 r/min for 1-3 min, and uniformly dispersing;
s3, cooling the phase A raw material obtained in the step S2 to 45 ℃, adding the phase B raw material, and uniformly stirring at the speed of 600-800 r/min to obtain a primary mixed material;
and S4, adding the phase C into the primary mixed material obtained in the S3, stirring at the rotating speed of 600-800 r/min for 5-20 min, and uniformly mixing to obtain the binary spray for resisting the damage of blue light to the skin.
Example 2
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
97.158 parts of water, 5 parts of betaine, 0.2 part of EDTA disodium, 0.1 part of beta-glucan, 0.4 part of hyaluronic acid, 2 parts of glycerol, 6 parts of butanediol, 1 part of 1, 2-hexanediol and 1 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.2 part of tocopherol acetate, 0.4 part of PEG-40 hydrogenated castor oil and 0.4 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
2 parts of PEG/PPG/polytetramethylene glycol-8/5/3 glycerol and 6 parts of aqueous coating cerium oxide;
the preparation method is the same as that of example 1.
Example 3
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
79.19 parts of water, 2 parts of betaine, 0.01 part of EDTA disodium, 0.001 part of beta-glucan, 0.05 part of hyaluronic acid, 2 parts of glycerol, 4 parts of butanediol, 0.4 part of 1, 2-hexanediol and 0.4 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.05 part of tocopherol acetate, 0.15 part of PEG-40 hydrogenated castor oil and 0.15 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.4 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 4 parts of aqueous coating cerium oxide;
the preparation method is the same as that of example 1.
Example 4
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
86.389 parts of water, 3 parts of betaine, 0.05 part of EDTA disodium, 0.01 part of beta-glucan, 0.1 part of hyaluronic acid, 3 parts of glycerol, 6 parts of butanediol, 0.6 part of 1, 2-hexanediol and 0.6 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.15 part of tocopherol acetate, 0.25 part of PEG-40 hydrogenated castor oil and 0.25 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.6 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 6 parts of aqueous coating cerium oxide;
the preparation method is the same as that of example 1.
Example 5
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
84.372 parts of water, 1.5 parts of betaine, 0.02 part of EDTA disodium, 0.008 part of beta-glucan, 0.1 part of hyaluronic acid, 1.5 parts of glycerol, 5.5 parts of butanediol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.1 part of tocopherol acetate, 0.2 part of PEG-40 hydrogenated castor oil and 0.2 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.5 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 5 parts of aqueous coating cerium oxide;
the preparation method is the same as that of example 1.
Comparative example 1
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
84.372 parts of water, 1.5 parts of betaine, 0.02 part of EDTA disodium, 0.008 part of beta-glucan, 0.1 part of hyaluronic acid, 1.5 parts of glycerol, 5.5 parts of butanediol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.1 part of tocopherol acetate, 0.2 part of PEG-40 hydrogenated castor oil and 0.2 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.5 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 5 parts of cerium oxide;
the preparation method is the same as that of example 1.
Comparative example 2
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
84.372 parts of water, 1.5 parts of betaine, 0.02 part of EDTA disodium, 0.008 part of beta-glucan, 0.1 part of hyaluronic acid, 1.5 parts of glycerol, 5.5 parts of butanediol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.1 part of tocopherol acetate, 0.2 part of PEG-40 hydrogenated castor oil and 0.2 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.5 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerol;
the preparation method is the same as that of example 1.
Comparative example 3
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
84.372 parts of water, 1.5 parts of glycerol, 5.5 parts of butanediol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.1 part of tocopherol acetate, 0.2 part of PEG-40 hydrogenated castor oil and 0.2 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.5 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 5 parts of aqueous coating cerium oxide;
the preparation method is the same as that of example 1.
Comparative example 4
A binary spray for resisting the damage of blue light to skin is composed of the following components in parts by weight: the composite material comprises a phase A, a phase B and a phase C, wherein the phase A comprises the following components in parts by weight:
84.372 parts of water, 1.5 parts of betaine, 0.02 part of EDTA disodium, 0.008 part of beta-glucan, 0.1 part of hyaluronic acid, 1.5 parts of glycerol, 5.5 parts of butanediol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.2 part of PEG-40 hydrogenated castor oil;
the phase C comprises the following components in parts by weight:
0.5 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 5 parts of aqueous coating cerium oxide;
the preparation method is the same as that of example 1.
In the above examples 1 to 5 and comparative examples 3 to 4, the aqueous coating cerium oxide is composed of the following components in parts by weight:
46 parts of poloxamer, 5 parts of cerium oxide,
the preparation method comprises the following steps: dissolving poloxamer in water to obtain a poloxamer aqueous solution, dissolving cerium oxide in nitric acid to obtain a nitric acid solution of cerium oxide, dropwise adding the nitric acid solution of cerium oxide into the poloxamer aqueous solution, and stirring for 24 hours to volatilize the nitric acid, thereby obtaining the water-based coated cerium oxide.
The following performance tests were performed on the binary sprays prepared in examples 1-5 and comparative examples 1-4:
1. anti-blue light test
The blue light can induce to generate substances such as Reactive Oxygen Species (ROS) and the like, so that the skin generates oxidative stress to cause skin aging, skin diseases and the like.
When testing, a 96-well blackboard was used, and 100. mu.L of human keratinocyte HaCaT cells were added to each well, and 5% CO was added at 37 ℃ to2And 95% humidity incubator for 24 hours, using the examples 1 ~ 5 and comparative examples 1 ~ 4 preparation of the binary spray treatment of cells, the addition of 1%, after treatment and continued to culture for 24 hours, and with LED (430nm, 1900lux) blue light irradiation 4 hours, using the fluorometer (Ex 380nm, Em 420nm) measurement of fluorescence intensity, repeat the measurement of 6 times to get the average value, wherein, the control group is not used in the examples and comparative examples preparation of the binary spray treatment, the measurement results are shown in Table 1,
TABLE 1 blue light resistance test results for the binary sprays prepared in examples 1-5 and comparative examples 1-4
As can be seen from Table 1, the level of active oxygen in cells of a control group after 4 hours of blue light irradiation is increased by 179.41%, when the cells are treated by the binary spray of examples 1 to 5, the increment of the active oxygen in the cells is obviously reduced, which shows that the binary spray prepared in examples 1 to 5 of the invention has a good elimination effect on the active oxygen generated by blue light induction, and well resists the damage of the blue light to the skin, and the increment of the active oxygen in cells treated by the binary spray of examples 1 to 5 is obviously resisted by comparative examples 1 to 4, wherein the aqueous coated cerium oxide is replaced by cerium oxide in comparative example 1, the aqueous coated cerium oxide in the C-phase raw material is absent in comparative example 2, which shows that compared with the addition of cerium oxide, the addition of cerium oxide after the preparation of the aqueous cerium oxide in poloxamer into the binary spray can fully exert the blue light resistance effect of cerium oxide, the technical problem that in the prior art, cerium oxide is difficult to disperse in water and cannot exert the effect in binary spraying is well solved; the absence of betaine, disodium EDTA, beta-glucan and hyaluronic acid in the phase A raw material in the comparative example 3 and the absence of tocopheryl acetate and PPG-30 cetyl ether in the phase B raw material in the comparative example 4 indicate that the A, B, C phase raw materials in the formula are compatible with each other, so that the blue light resistance effect of cerium oxide in the binary spray is enhanced, and the prepared binary spray has a better blue light resistance effect.
2. The melanin inhibiting performance: 20 female volunteers, whose average age was 40 years, applied the binary sprays prepared in examples 1 to 5 and comparative examples 1 to 4 to the face, respectively, 2 times per day for 28 days, and no other product was used during the test, and the whitening efficacy of the above products was evaluated by measuring the melanin content (taking an average value) of the facial skin 1 day before and 28 days after the binary spray was applied using a skin melanin tester, and the test results are shown in table 2:
TABLE 2 test results of melanin inhibiting performance of the binary sprays prepared in examples 1 to 5 and comparative examples 1 to 4
As can be seen from table 2, after 28 days of using the binary sprays of examples 1 to 5 of the present invention, the melanin content of the facial skin is significantly reduced, the melanin inhibition rate reaches over 46.5%, the melanin inhibition rate of example 5 even reaches 53.5%, and the maximum melanin inhibition rate of using the binary sprays of comparative examples 1 to 4 is only 25.2%, so that it is demonstrated that A, B, C phase raw materials in the binary spray formula of the present invention are compatible with each other, the melanin content of the skin is effectively reduced, and a good whitening effect is achieved.
3. Moisture retention: the moisture content of the skin stratum corneum is measured according to a capacitance method specified in QB/T4256-2011 'guidelines for evaluating moisturizing effects of cosmetics'. During testing, 25 female volunteers are selected, the average age is 30 years old, the test subjects are in the female volunteers, the positions of the test subjects are the inner sides of the forearms of the hands of the test subjects, a use area and a blank control area are divided before use, binary sprays prepared in examples 1-5 and comparative examples 1-4 are respectively sprayed on the use area, the blank control group is not treated, the moisture content of the stratum corneum of the use area and the moisture content of the stratum corneum of the blank control area are respectively tested by a skin moisture tester before use and after use for 4 hours, and the test results are shown in a table 3:
TABLE 3 results of moisture retention test of the binary sprays prepared in examples 1 to 5 and comparative examples 1 to 4
As can be seen from table 3, after 4 hours of using the binary spray of examples 1 to 5 of the present invention, the water content of the skin of the volunteer was increased by more than 11.9%, the water content of the binary spray of example 5 was increased by 12.8%, the highest water content of comparative examples 1 to 4 was only 10.6%, and the highest water content of comparative examples 3 was even as low as 2.6%, which indicates that A, B, C phases of the raw materials in the binary spray formulation of the present invention are compatible with each other, effectively increasing the water content of the stratum corneum, and having a good moisturizing effect.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. The binary spray for resisting the damage of blue light to skin is characterized by comprising the following components in parts by weight: comprises that
Phase A, phase B and phase C,
the phase A consists of the following components:
water, betaine, EDTA disodium, beta-glucan, hyaluronic acid, glycerol, butanediol, 1, 2-hexanediol, and p-hydroxyacetophenone;
the phase B consists of the following components:
tocopheryl acetate, PEG-40 hydrogenated castor oil, PPG-30 cetyl ether;
the phase C consists of the following components:
PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, aqueous coating cerium oxide;
wherein the aqueous coating cerium oxide consists of the following components in parts by weight: 46 parts of poloxamer and 5 parts of cerium oxide;
the preparation method of the aqueous coating cerium oxide comprises the following steps: dissolving poloxamer in water to obtain a poloxamer aqueous solution, dissolving cerium oxide in nitric acid to obtain a nitric acid solution of cerium oxide, dropwise adding the nitric acid solution of cerium oxide into the poloxamer aqueous solution, and stirring for 24 hours to volatilize the nitric acid, thereby obtaining the water-based coated cerium oxide.
2. The binary spray according to claim 1, wherein said blue light is a blue light-resistant blue light-curable liquid,
the phase A comprises the following components in parts by weight:
75.3-97.158 parts of water, 0.5-5 parts of betaine, 0.01-0.2 part of EDTA disodium, 0.001-0.1 part of beta-glucan, 0.001-0.4 part of hyaluronic acid, 0.5-2 parts of glycerol, 0.5-6 parts of butanediol, 0.1-1 part of 1, 2-hexanediol and 0.1-1 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.01-0.2 part of tocopherol acetate, 0.01-0.4 part of PEG-40 hydrogenated castor oil and 0.01-0.4 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.1-2 parts of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin, 2-7 parts of poloxamer and 1-6 parts of water-based coated cerium oxide.
3. The binary spray according to claim 1, wherein said blue light is a blue light-resistant blue light-curable liquid,
the phase A comprises the following components in parts by weight:
79.19-86.389 parts of water, 2-3 parts of betaine, 0.01-0.05 part of EDTA disodium, 0.001-0.01 part of beta-glucan, 0.05-0.1 part of hyaluronic acid, 2-3 parts of glycerol, 4-6 parts of butanediol, 0.4-0.6 part of 1, 2-hexanediol and 0.4-0.6 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.05-0.15 part of tocopherol acetate, 0.15-0.25 part of PEG-40 hydrogenated castor oil and 0.15-0.25 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.4-0.6 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 4-6 parts of water-based coating cerium oxide.
4. The binary spray according to claim 1, wherein said blue light is a blue light-resistant blue light-curable liquid,
the phase A comprises the following components in parts by weight:
84.372 parts of water, 1.5 parts of betaine, 0.02 part of EDTA disodium, 0.008 part of beta-glucan, 0.1 part of hyaluronic acid, 1.5 parts of glycerol, 5.5 parts of butanediol, 0.5 part of 1, 2-hexanediol and 0.5 part of p-hydroxyacetophenone;
the phase B comprises the following components in parts by weight:
0.1 part of tocopherol acetate, 0.2 part of PEG-40 hydrogenated castor oil and 0.2 part of PPG-30 cetyl ether;
the phase C comprises the following components in parts by weight:
0.5 part of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and 5 parts of aqueous coating cerium oxide.
5. A method of preparing a binary spray for protecting skin from damage by blue light, comprising the steps of:
s1, weighing raw materials of each phase according to the formula of the binary spray for resisting the damage of blue light to skin, which is disclosed by any one of claims 1 to 4, for later use;
s2, stirring the phase A raw material, heating to 86-88 ℃, and homogenizing and dispersing uniformly;
s3, cooling the phase A raw material obtained in the step S2 to 45 ℃, adding the phase B raw material, and uniformly stirring to obtain a primary mixed material;
and S4, adding the phase C into the primary mixed material obtained in the step S3, and uniformly stirring to obtain the binary spray for resisting the damage of blue light to the skin.
6. The method of claim 5, wherein the stirring speed in step S2 is 600-800 r/min.
7. The method of claim 5, wherein the homogenizing in step S2 is performed at a speed of 1500-2500 r/min for 1-3 min.
8. The method of claim 5, wherein the stirring speed in step S3 is 600-800 r/min.
9. The method for preparing a binary spray for resisting the damage of blue light to the skin according to claim 5, wherein the stirring in step S4 is performed at a rotation speed of 600-800 r/min for 5-20 min.
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