CN105343244A - External medicine composition for treating verruca plana and application of external medicine composition - Google Patents
External medicine composition for treating verruca plana and application of external medicine composition Download PDFInfo
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- CN105343244A CN105343244A CN201510882609.0A CN201510882609A CN105343244A CN 105343244 A CN105343244 A CN 105343244A CN 201510882609 A CN201510882609 A CN 201510882609A CN 105343244 A CN105343244 A CN 105343244A
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- medicine composition
- verruca plana
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/09—Lichens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention relates to an external medicine composition for treating verruca plana and application of the external medicine composition. The external medicine composition is an external gelata, a cream or an ointment prepared from raw herbal materials and pharmaceutic adjuvants, wherein the raw herbal materials comprise the following components in parts by weight: 10-15 parts of dry root of morinda officinalis, 28-36 parts of spreading hedyotis herb, 4-8 parts of folium mori, 15-25 parts of taraxacum, 15-25 parts of honeysuckle stem and 9-14 parts of parmelia tinctorum Despr. The external medicine composition has the advantages that the antiviral, anti-inflammatory and bactericidal functions are relatively strong, the treating effect on verruca plana is good, the effective rate is high, no any scar is left after verruca plana is cured, the treating efficiency is high, and any toxic or side effect is avoided.
Description
Technical field
The invention belongs to medical art, in particular to a kind of externally-applied medicinal composition and application thereof for the treatment of verruca plana.
Background technology
Verruca plana is caused by human papillomaviral infection, and self and have stronger infectiousness between men.This disease is apt to occur in the exposure portion such as face, the back of the hand, cervical region, arm of women especially, makes ragazza worried most.Verruca plana sickness rate is high, and treatment difficulty is large, is dermatologist's headache always.Clinical manifestation is skin-color or beige syringe needle to the large flat pimple of Semen phaseoli radiati, rounded, oval or polygon, and boundary is clear, can dense distribution or owing to scratch and in the linear alignment local, generally without obvious subjective symptoms or there be micro-itching.The course of disease is chronic process, sustainable several months or several years.By direct or indirect contagion.Mostly traditional treatment is oral, intramuscular injection or external related anti-viral medicine.But because Virus parasite is in human epidermal cell, be all difficult to reach effective concentration so oral with intramuscular injection, escalated dose may cause untoward reaction again.Current doctor trained in Western medicine mainly adopts following therapeutic scheme: topical medication: external adopts tretinoin ointment, the not special ointment of miaow, 5% antimony tartrate potassium solution, 5% fluorine arteries and veins to mutter the treatments such as steep ointment; Physical therapy: comprise freezing and laser therapy; Oral medication: oral isotretinoin capsule, magnesium oxide or hexamethylenamine are treated.Existing drug treatment suppresses viral, antitoxin side effect is less; Physiotherapy easily causes recurrence; Some patients leaves the sequela such as cicatrix, pigmentation after treatment, and therapeutic effect is not good enough.
Summary of the invention
Applicant is through clinical practice for many years, and utilize Chinese medicine external to treat this disease, not only achieve good curative effect, and side effect is little, price is low, and patient willingness accepts.Therefore, a kind of externally-applied medicinal composition for the treatment of verruca plana is the object of the present invention is to provide extremely to apply.
The object of the present invention is achieved like this:
A kind of externally-applied medicinal composition for the treatment of verruca plana, be prepared from by traditional Chinese medicinal material raw materials and pharmaceutic adjuvant, described traditional Chinese medicinal material raw materials comprises the component of following weight portion: Radix Morindae Officinalis 10-15 part, Herba Hedyotidis Diffusae 28-36 part, Folium Mori 4-8 part, Herba Taraxaci 15-25 part, Caulis Lonicerae 15-25 part, Parmelia tinctorum Despr. 9-14 part.
Further preferably, a kind of externally-applied medicinal composition for the treatment of verruca plana as above, traditional Chinese medicinal material raw materials is wherein made up of the component of following weight portion: Radix Morindae Officinalis 12-14 part, Herba Hedyotidis Diffusae 30-33 part, Folium Mori 5-7 part, Herba Taraxaci 18-22 part, Caulis Lonicerae 18-22 part, Parmelia tinctorum Despr. 11-13 part.
In the most preferred embodiment of the present invention, a kind of externally-applied medicinal composition for the treatment of verruca plana as above, traditional Chinese medicinal material raw materials is wherein made up of the component of following weight portion: Radix Morindae Officinalis 13 parts, Herba Hedyotidis Diffusae 32 parts, 6 parts, Folium Mori, Herba Taraxaci 20 parts, Caulis Lonicerae 20 parts, Parmelia tinctorum Despr. 12 parts.
The application of above-mentioned traditional Chinese medicinal material raw materials compositions in the external used medicine of preparation treatment verruca plana.External used medicine preferably described further comprises gel, ointment and ointment.
It should be noted that, the Chinese crude drug of pharmaceutical composition of the present invention selected by preparation process has following source: Radix Morindae Officinalis selects the dry root of Maguireothamnus speciosus Radix Morindae Officinalis MorindaofficinalisHow, steaming method (appendix II D) according to pharmacopeia steams thoroughly, remove core while hot, cutting, dry.Herba Hedyotidis Diffusae selects the dry herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae HedyotisdiffusaWilld..Folium Mori select the dried leaves of moraceae plants Mulberry MorusalbaL..Herba Taraxaci selects the dry herb of feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz..Caulis Lonicerae selects the dry stem branch of caprifoliaceae plant Radix Ophiopogonis LonicerajaponicaThunb..Parmelia tinctorum Despr. selects the thallus of Parmeliaceae plant prunus mume (sieb.) sieb.et zucc. clothing ParmeliatinctorumDespr..
Compared with prior art, Chinese medicine heat clearing away addiction of the present invention is dirty, wart is dispelled in removing toxic substances, dehumidifying, the external preparation preparation adopted is simple, good absorbing effect, and duration of efficacy is long, there is stronger antiviral and anti-inflammation and sterilization effect, for the treatment good effect of verruca plana, effective percentage is high, can not leave any cicatrix after healing, instant effect, without any side effects.
Detailed description of the invention
Following examples are only some embodiments of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from essentiality content of the present invention; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine extract ointment
Take Radix Morindae Officinalis 1.3kg, Herba Hedyotidis Diffusae 3.2kg, Folium Mori 0.6kg, Herba Taraxaci 2.0kg, Caulis Lonicerae 2.0kg, Parmelia tinctorum Despr. 1.2kg, mixing, is placed in extraction vessel, adds 12 times of purified water, soak 30 minutes, then intense fire boils rear slow fire boiling 2 hours, and four layers of filtered through gauze obtain filtrate, filtering residue repeats to decoct and extracts once, merges twice filtrate, and heating is concentrated into thick paste, dry, pulverize, obtain Chinese medicine extract dry powder.Accurately take 2g Chinese medicine extract dry powder, in the vaseline joining 30g melting and 20mL soybean oil, stir, precision takes 0.3g ethyl hydroxybenzoate as antiseptic, adds, and mixing, obtains Chinese medicine extract ointment.
Embodiment 2: Chinese medicine ointment is to the observation of curative effect of face flat wart patient
Face flat wart patient 62 example through making a definite diagnosis, there are normal skin tone or filbert hatpin head in patient face to flat pimple without inflammatory of the circle of Seem Lablab Album size, ellipse or polygon, smooth surface, and matter is hard, is dispersed in or intensive, also can merge, or slight pruritus; Histopathologic findings display spinous layer of epidermis is plump, papillomatous hyperplasia and hyperkeratosis, companion's parakeratosis; Spinous layer top and granular layer have Empity veside cell, nuclear hyperchromatism, basophilia.
In 62 routine patients, male 29 example, women 33 example, 17 ~ 32 years old age, average (27.1 ± 2.4) year, the course of disease 3 months ~ 5 years, average (2.8 ± 0.6) year.All patients are divided at random test group 31 example and matched group 31 example.Two groups of difference there are no significant differences in sex, age, course of disease distribution etc., have comparability.
After treatment starts, after test group patient cleans face, directly outer painting Chinese medicine extract ointment of the present invention (preparing by the formulation and technology of embodiment 1); After matched group patient cleans face, directly outer painting 0.1% adapalene gel (authentication code: the accurate word H20113373 of traditional Chinese medicines, production unit: Jiangsu Fubang .Pharm Co., Ltd.).In evening 1 time every day, continuous use evaluated curative effect after 6 weeks.Treatments period does not use other antiviral to take orally or medicine for external use, and efficacy assessment standard is as follows: cure: skin lesion disappears, without newly going out erythra; (2) take a turn for the better: erythra comparatively before flattens, disappear more than 30% or have indivedual new rash to occur; (3) do not heal: erythra is unchanged or disappear less than 30%.Total effective rate=(cure+take a turn for the better) total number of cases × 100% of/patient.
Can be found out by the test statistics result of table 1, after the Drug therapy of 6 weeks, matched group cure rate 25.8%, improvement rate 45.2%, after treatment, total effective rate is 71.0%; Test group cure rate 71.0%, improvement rate 25.8%, after treatment, total effective rate is 96.8%.Obviously, the treated effect of test group to verruca plana is obviously better than matched group.
Table 1 liang group patient clinical comparitive study (example)
Claims (5)
1. treat the externally-applied medicinal composition of verruca plana for one kind, be prepared from by traditional Chinese medicinal material raw materials and pharmaceutic adjuvant, it is characterized in that, described traditional Chinese medicinal material raw materials comprises the component of following weight portion: Radix Morindae Officinalis 10-15 part, Herba Hedyotidis Diffusae 28-36 part, Folium Mori 4-8 part, Herba Taraxaci 15-25 part, Caulis Lonicerae 15-25 part, Parmelia tinctorum Despr. 9-14 part.
2. a kind of externally-applied medicinal composition for the treatment of verruca plana as claimed in claim 1, it is characterized in that: described traditional Chinese medicinal material raw materials is made up of the component of following weight portion: Radix Morindae Officinalis 12-14 part, Herba Hedyotidis Diffusae 30-33 part, Folium Mori 5-7 part, Herba Taraxaci 18-22 part, Caulis Lonicerae 18-22 part, Parmelia tinctorum Despr. 11-13 part.
3. a kind of externally-applied medicinal composition for the treatment of verruca plana as claimed in claim 2, it is characterized in that, described traditional Chinese medicinal material raw materials is made up of the component of following weight portion: Radix Morindae Officinalis 13 parts, Herba Hedyotidis Diffusae 32 parts, 6 parts, Folium Mori, Herba Taraxaci 20 parts, Caulis Lonicerae 20 parts, Parmelia tinctorum Despr. 12 parts.
4. the application of the traditional Chinese medicinal material raw materials compositions described in any one of claim 1-3 in the external used medicine of preparation treatment verruca plana.
5. application according to claim 4, is characterized in that, described external used medicine comprises gel, ointment and ointment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510882609.0A CN105343244A (en) | 2015-12-03 | 2015-12-03 | External medicine composition for treating verruca plana and application of external medicine composition |
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| CN201510882609.0A CN105343244A (en) | 2015-12-03 | 2015-12-03 | External medicine composition for treating verruca plana and application of external medicine composition |
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| CN105343244A true CN105343244A (en) | 2016-02-24 |
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| CN201510882609.0A Withdrawn CN105343244A (en) | 2015-12-03 | 2015-12-03 | External medicine composition for treating verruca plana and application of external medicine composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878581A (en) * | 2016-05-26 | 2016-08-24 | 孙明香 | Liquid traditional Chinese medicine for treating verruca plana and preparation method thereof |
| CN106266868A (en) * | 2016-08-31 | 2017-01-04 | 王秀娟 | A kind of anti-acne anti-acne trace is dispelled the externally-applied medicinal composition of verruca plana |
-
2015
- 2015-12-03 CN CN201510882609.0A patent/CN105343244A/en not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| 夏兰: "鲜矾擦剂治疗扁平疣46例", 《河南中医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878581A (en) * | 2016-05-26 | 2016-08-24 | 孙明香 | Liquid traditional Chinese medicine for treating verruca plana and preparation method thereof |
| CN106266868A (en) * | 2016-08-31 | 2017-01-04 | 王秀娟 | A kind of anti-acne anti-acne trace is dispelled the externally-applied medicinal composition of verruca plana |
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Application publication date: 20160224 |