CN105596480A - Traditional Chinese medicine composition for treating rhinitis as well as preparation method thereof and method for preparing collunarium - Google Patents
Traditional Chinese medicine composition for treating rhinitis as well as preparation method thereof and method for preparing collunarium Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating rhinitis as well as a preparation method thereof and a method for preparing collunarium, and relates to the traditional Chinese medicine composition as well as the preparation method thereof and the method for preparing collunarium. The traditional Chinese medicine composition for treating rhinitis comprises the following bulk drugs in parts by weight: 1.04-1.56 parts of cholic acid, 1.2-1.8 parts of hyodeoxycholic acid, 1.6-2.4 parts of baicalin, 8-12 parts of cape jasmine fruits, 8-12 parts of water buffalo horn powder, 16-24 parts of mother-of-pearl, 28-42 parts of honeysuckle flowers, and 64-96 parts of isatis roots. The preparation method comprise the following steps: effective components are extracted by alcohol extract and other modes, the effective components are mixed, and the product is prepared. The traditional Chinese medicine composition is suitable for nasal obstruction, nose pain and paranasal sinus refusing to pressure due to acute and chronic rhinitis, and nasosinusitis, nasal cavity mucous membrane ulcer, poor sense of smell, sneeze, dizziness, headache and other symptoms.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof and prepare the method for collunarium with it.
Background technology
Rhinitis is schneiderian membrance or mucous membrane undertissue because virus infections, courses of infection, stimulus stimulation etc., cause schneiderian membrance orMucous membrane undertissue is impaired, caused acute or chronic inflammation. Rhinitis causes producing too much mucus, conventionally causes runny nose, noseThe symptoms such as plug. At present, doctor trained in Western medicine is mainly taked anti-inflammatory, detumescence, and pain relieving, the method treatments such as puncture cleaning and operative treatment, itsEffect is undesirable, and cure rate is not high, uses for a long time the method body to produce tolerance, thereby is transformed into step by step chronic disease.The existing traditional Chinese medical science is the method treatments that adopt oral Chinese patent medicine of Chinese medicine more, and the course for the treatment of is long, and effect is undesirable.
Summary of the invention
To the object of the invention is in order addressing the above problem, and to have proposed a kind of Chinese medicine composition and preparation side thereof for the treatment of rhinitisMethod and prepare the method for collunarium with it.
A kind of Chinese medicine composition for the treatment of rhinitis of the present invention, it comprises the bulk drug of following parts by weight: cholic acid 1.04～1.56 parts, 1.2～1.8 parts of hyodesoxycholic acids, 1.6～2.4 parts of scutellosides, 8～12 parts of cape jasmines, Cornu Bubali powder 8～1264～96 parts of part, 16～24 parts of mother-of-pearls, 28～42 parts of honeysuckles and Radix Isatidis.
The preparation method of a kind of Chinese medicine composition for the treatment of rhinitis of the present invention, it carries out according to following steps:
One, take by weight following component: 1.04～1.56 parts of cholic acid, 1.2～1.8 parts of hyodesoxycholic acids, scutelloside1.6～2.4 parts, 8～12 parts of cape jasmines, 8～12 parts of Cornu Bubali powders, 16～24 parts of mother-of-pearls, 28～42 parts of honeysuckles and64～96 parts of Radix Isatidis;
Two, Radix Isatidis boiling step 1 being taken 2 times, each 1 hour, collecting decoction, filtered, and filtrate is concentratedTo relative density be 1.0～1.1; Then in the filtrate after concentrated, add ethanol to make alcohol content reach 60%, refrigeration at 20 DEG C,Filter, collect filtrate, and reclaim ethanol; To the water that adds 2～4 times of amounts in filtrate, obtain Radix Isatidis liquid;
Three, cape jasmine boiling step 1 being taken 2 times, decocts 1 hour for the first time, decocts for the second time 0.5 hour,Collecting decoction, filters, and it is 1.0～1.1 that filtrate is concentrated into relative density, then in the filtrate after concentrated, adds ethanol to make alcoholContent reaches 60%, and refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; To the water that adds 2～4 times of amounts in filtrate,Obtain cape jasmine liquid;
Four, honeysuckle boiling step 1 being taken 2 times, each 0.5 hour, collecting decoction, filtered, and filtrate is denseBeing reduced to relative density is 1.0～1.1, then in the filtrate after concentrated, adds ethanol to make alcohol content reach 75%, filters, and collectsFiltrate, filtrate regulates pH value to 0.8, and refrigeration at 20 DEG C, filters, and collect filtrate, and reclaim ethanol, then to filtrateIn add ethanol to make alcohol content reach 85%, refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; In filtrateAdd the water of 2～4 times of amounts, honeysuckle liquid;
Five, saturated barium hydroxide solution hydrolysis 7～9 hours for Cornu Bubali powder step 1 being taken, filters, and collects waterThe filtrate of horn powder;
The Concha Margaritifera powder that step 1 is taken is used sulphuric acid hydrolysis 7～9 hours, filters, and collects the filtrate of Concha Margaritifera powder; MergeThe filtrate of Cornu Bubali powder and the filtrate of Concha Margaritifera powder, must mix filtrate, regulates pH value to 3.5～4.0 of mixing filtrate, filterCross, collect filtrate, in filtrate, add ethanol to make alcohol content reach 60%, refrigeration at 20 DEG C, filters, and collects filtrate,And reclaim ethanol; To the water that adds 2～4 times of amounts in filtrate, obtain the mixed liquor of Cornu Bubali powder and Concha Margaritifera powder;
Six, after the mixed liquor of cape jasmine liquid, Radix Isatidis liquid and Cornu Bubali powder and Concha Margaritifera powder is merged, by the mixed liquor after mergingJoin in 75% ethanolic solution of cholic acid, hyodesoxycholic acid, mix, add ethanol and make ethanol content reach 75%, then regulatePH value to 7.0, refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; To the water that adds 2～4 times of amounts in filtrate,Must mix liquid;
Seven, scutelloside step 1 being taken dissolves with water for injection, and adjust pH to 7.5 adds the honeysuckle of step 4Extract, mixes, and merges with the mixed liquid of step 6, mix, then after charcoal treatment, refrigeration, embedding, sterilizing,Obtain described Chinese medicine composition.
The method of preparing collunarium of the Chinese medicine composition of a kind of use of the present invention treatment rhinitis claimed in claim 1, it isCarry out according to following step: by the Chinese medicine composition of claim 1 extract and quality percentage composition be 0.9% rawAfter reason salt solution mixes, obtain liquid collunarium.
The present invention comprises following beneficial effect:
The invention provides a kind of new medicine composition for the treatment of rhinitis, medicine source is easy to get, and drug resistance is low, side effect and bad anti-Should lack. This composition is made to nasal douche medicament, and method is simple, and effect is remarkable. The method is in clinical practiceCure case many cases, have its unique advantage and vast potential for future development, be worthy to be popularized.
The Chinese medicine composition that the present invention uses is through the fortune of clinical practice of Chinese medicine summary for many years by nasal cavity drip-injection method treatment rhinitisBy the empirical method going out, there is the experimental basis of science, each taste Chinese medicine can be brought into play pharmacological action separately, can play again phaseMutual synergy, strengthens pharmacological action.
The side of traditional Chinese medicinal components of the present invention separates as follows:
Cholic acid: one of many animals bile active ingredient. There is antipyretic, anti-inflammatory, antiallergy, the effect such as antibacterial, antiviral,Clinically be used for treating the diseases such as pyreticosis coma, apoplexy phlegm fan, abscess of throat, aphthae. Modern pharmacological research is by measuringThe content of second messenger cAMP in PGE2 content and histocyte in inflammatory mediator, has further proved the antiinflammatory action of cholic acidMechanism.
Hyodesoxycholic acid: the get on bile acid of hydroxyl of a kind of C-7, be cholic acid lose an oxygen atom derivative and one freeBile acid mainly exists with taurine, glycine combining form in bile. There is the effects such as the choleresis of promotion, anti-inflammatory.
Scutelloside: the index composition of the root of large-flowered skullcap, has heat-clearing, purging intense heat, removing toxic substances, hemostasis, the effect such as antiabortive. Scutelloside energyEnough suppress enzymatic activity, the reaction of antibacterial, inflammation-inhibiting, antiviral, remove free radical. Multiple virus is had to deactivation,The oozing out of inflammation, oedema are all had to obvious inhibitory action, and the heating that various virus infectionses are caused has trivial solution heat effect.
Cape jasmine: the fruit of madder wort cape jasmine. There is the effects such as the liver of protecting, cholagogic, step-down, calmness, hemostasis, detumescence.Be usually used in treating the diseases such as icteric hepatitis, bruise, hypertension, diabetes at tcm clinical practice. Relevant research shows, cape jasmineMedicinal extract can significantly suppress acetic acid and bring out vasopermeability increase, has good antiinflammatory action.
Cornu bubali: the substitute of Chinese medicine rhinoceros horn, has heat-clearing, cool blood, arresting convulsion, the effect of removing toxic substances. Cold warm epidemic disease is used for curing the woundHeat invading xuefen, frightened mad, agitation, delirium, macula, jaundice, spits blood, bleeding from five sense organs or subcutaneous tissue, lower blood, the diseases such as swollen ulcer drug. Relevant grindingStudy carefully discovery: compound cornu bubali water extract and alcohol extract cause rat acute urarthritis, glacial acetic acid due to uric acid sodiumMice pain and mice caused by dimethylbenzene xylene auricular concha inflammation have significant inhibitory action.
Mother-of-pearl: the powder of shellfish nacre, has calming the liver; The arresting convulsion of calming the nerves; The effect of clearing liver and improving vision. Cure mainly: headPain is dizzy; Palpitation and insomnia; Demented frightened epilepsy; The hot hot eyes of liver. Modern pharmacological research can suppress dimethylbenzene by mother-of-pearl to be causedThe swollen and acetic acid of the rat paw that Mice Auricle is swollen, egg white causes stimulate increasing of caused abdominal cavity capillary permeability,Show that mother-of-pearl and compound thereof have good antiphlogistic effects.
Honeysuckle: the flower that the dry flower of perennial half evergreen prehensile bejuco honeysuckle of Caprifoliaceae or band are just opened. GoldHoneysuckle flower contains the active ingredients such as chlorogenic acid, flavonoids, saponin(e, wherein contains a large amount of reduction groups, therefore to various pathogensAll having inhibitory action, is a kind of broad-spectrum antiseptic Chinese medicine. Through modern pharmacological research honeysuckle to staphylococcus aureus, hemolyticStreptococcus, dysentery, typhoid fever, diplococcus meningitidis, pseudomonas aeruginosa all have obvious inhibitory action, and have the immunity of enhancingFunction.
Radix Isatidis: have clearing heat and detoxicating, effect of cool blood relieve sore throat. Poison while being usually used in warm epidemic disease, heating pharyngalgia, febrile virulent maculae, ZhaThe cheek, scarlet fever, major part pestilence, erysipelas, carbuncle swells and waits disease. Modern pharmacology research shows, Radix Isatidis paraxylene causes increasingAdd that equal mice ear, carrageenan cause that rat paw is swollen, rat granuloma hyperblastosis and acetic acid causes mouse capillaryPermeability all has inhibitory action. Show that Radix Isatidis has good antiinflammatory action.
In this prescription, each taste Chinese medicine is in strict accordance with traditional Chinese medicine " monarch, minister, help, the make " principles of formulating prescriptions, and science compatibility forms,Animal cholic acid, cornu bubali and mother-of-pearl in side is that monarch drug in a prescription has well relieving convulsion, the anti-inflammatory of bringing down a fever, improves body immunityEffect, the root of large-flowered skullcap, cape jasmine, honeysuckle, Radix Isatidis are that ministerial drug has stronger broad-spectrum antiviral, antibacterial activity, can suppressVarious virus, again can anti-inflammatory and endotoxin, and effect is remarkable. Cornu bubali, mother-of-pearl, cholic acid can improve body immunity,Strengthen supporting antiviral ability. Overall view is side entirely, and antiviral, antibacterium and antiinflammation are remarkable.
Detailed description of the invention
Detailed description of the invention one: a kind of Chinese medicine composition for the treatment of rhinitis of present embodiment, it comprises following parts by weightBulk drug: 1.04～1.56 parts of cholic acid, 1.2～1.8 parts of hyodesoxycholic acids, 1.6～2.4 parts of scutellosides, cape jasmine 8～1264～96 parts of part, 8～12 parts of Cornu Bubali powders, 16～24 parts of mother-of-pearls, 28～42 parts of honeysuckles and Radix Isatidis.
Detailed description of the invention two: present embodiment and detailed description of the invention one difference are: it comprises following parts by weightBulk drug: 1.1～1.50 parts of cholic acid, 1.4～1.8 parts of hyodesoxycholic acids, 1.8～2.4 parts of scutellosides, cape jasmine 10～1270～96 parts of part, 10～12 parts of Cornu Bubali powders, 18～24 parts of mother-of-pearls, 30～42 parts of honeysuckles and Radix Isatidis. OtherIdentical with detailed description of the invention one.
Detailed description of the invention three: present embodiment and detailed description of the invention one difference are: it comprises following parts by weightBulk drug: 1.2～1.50 parts of cholic acid, 1.5～1.8 parts of hyodesoxycholic acids, 2.0～2.4 parts of scutellosides, cape jasmine 10～1275～96 parts of part, 10～12 parts of Cornu Bubali powders, 20～24 parts of mother-of-pearls, 32～42 parts of honeysuckles and Radix Isatidis. OtherIdentical with detailed description of the invention one.
Detailed description of the invention four: present embodiment and detailed description of the invention one difference are: it comprises following parts by weightBulk drug: 1.3～1.50 parts of cholic acid, 1.6～1.8 parts of hyodesoxycholic acids, 2.2～2.4 parts of scutellosides, cape jasmine 10～1280～96 parts of part, 10～12 parts of Cornu Bubali powders, 22～24 parts of mother-of-pearls, 34～42 parts of honeysuckles and Radix Isatidis. OtherIdentical with detailed description of the invention one.
Detailed description of the invention five: present embodiment and detailed description of the invention one difference are: it comprises following parts by weightBulk drug: 1.4～1.50 parts of cholic acid, 1.7～1.8 parts of hyodesoxycholic acids, 2.3～2.4 parts of scutellosides, cape jasmine 10～1285～96 parts of part, 10～12 parts of Cornu Bubali powders, 23～24 parts of mother-of-pearls, 38～42 parts of honeysuckles and Radix Isatidis. OtherIdentical with detailed description of the invention one.
Detailed description of the invention six: present embodiment is with detailed description of the invention one difference: this Chinese medicine composition can be combinedFollowing ingredients: the flower bud of lily magnolia, Rhizoma Belamcandae. Other is identical with detailed description of the invention one.
Detailed description of the invention seven: present embodiment and detailed description of the invention one difference are: a kind of Chinese drug-treated group for the treatment of rhinitisCompound is combined with the flower bud of lily magnolia, Rhizoma Belamcandae according to following steps: the flower bud of lily magnolia extracts volatile oil; Rhizoma Belamcandae boiling 2 times, everyInferior 1 hour, collecting decoction, filtered, and it is 1.0～1.1 that filtrate is concentrated into relative density; Then in the filtrate after concentrated, addEnter ethanol and make alcohol content reach 60%, refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; In filtrate, add 2～4Doubly the water of amount, obtains Rhizoma Belamcandae liquid; Flower bud of lily magnolia liquid, Rhizoma Belamcandae liquid are mixed with the solution in embodiment one. Other is with concrete realExecute mode one identical.
Detailed description of the invention eight: present embodiment and detailed description of the invention one difference are: plant the Chinese traditional medicine composition for the treatment of rhinitisThing can also add metronidazole 8～12 weight portions. Other is identical with detailed description of the invention one.
Detailed description of the invention nine: the preparation method of a kind of Chinese medicine composition for the treatment of rhinitis of present embodiment, it be according toLower step is carried out:
One, take by weight following component: 1.04～1.56 parts of cholic acid, 1.2～1.8 parts of hyodesoxycholic acids, scutelloside1.6～2.4 parts, 8～12 parts of cape jasmines, 8～12 parts of Cornu Bubali powders, 16～24 parts of mother-of-pearls, 28～42 parts of honeysuckles and64～96 parts of Radix Isatidis;
Two, Radix Isatidis boiling step 1 being taken 2 times, each 1 hour, collecting decoction, filtered, and filtrate is concentratedTo relative density be 1.0～1.1; Then in the filtrate after concentrated, add ethanol to make alcohol content reach 60%, refrigeration at 20 DEG C,Filter, collect filtrate, and reclaim ethanol; To the water that adds 2～4 times of amounts in filtrate, obtain Radix Isatidis liquid;
Three, cape jasmine boiling step 1 being taken 2 times, decocts 1 hour for the first time, decocts for the second time 0.5 hour,Collecting decoction, filters, and it is 1.0～1.1 that filtrate is concentrated into relative density, then in the filtrate after concentrated, adds ethanol to make alcoholContent reaches 60%, and refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; To the water that adds 2～4 times of amounts in filtrate,Obtain cape jasmine liquid;
Four, honeysuckle boiling step 1 being taken 2 times, each 0.5 hour, collecting decoction, filtered, and filtrate is denseBeing reduced to relative density is 1.0～1.1, then in the filtrate after concentrated, adds ethanol to make alcohol content reach 75%, filters, and collectsFiltrate, filtrate regulates pH value to 0.8, and refrigeration at 20 DEG C, filters, and collect filtrate, and reclaim ethanol, then to filtrateIn add ethanol to make alcohol content reach 85%, refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; In filtrateAdd the water of 2～4 times of amounts, honeysuckle liquid;
Five, saturated barium hydroxide solution hydrolysis 7～9 hours for Cornu Bubali powder step 1 being taken, filters, and collects waterThe filtrate of horn powder;
The Concha Margaritifera powder that step 1 is taken is used sulphuric acid hydrolysis 7～9 hours, filters, and collects the filtrate of Concha Margaritifera powder; MergeThe filtrate of Cornu Bubali powder and the filtrate of Concha Margaritifera powder, must mix filtrate, regulates pH value to 3.5～4.0 of mixing filtrate, filterCross, collect filtrate, in filtrate, add ethanol to make alcohol content reach 60%, refrigeration at 20 DEG C, filters, and collects filtrate,And reclaim ethanol; To the water that adds 2～4 times of amounts in filtrate, obtain the mixed liquor of Cornu Bubali powder and Concha Margaritifera powder;
Six, after the mixed liquor of cape jasmine liquid, Radix Isatidis liquid and Cornu Bubali powder and Concha Margaritifera powder is merged, by the mixed liquor after mergingJoin in 75% ethanolic solution of cholic acid, hyodesoxycholic acid, mix, add ethanol and make ethanol content reach 75%, then regulatePH value to 7.0, refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; To the water that adds 2～4 times of amounts in filtrate,Must mix liquid;
Seven, scutelloside step 1 being taken dissolves with water for injection, and adjust pH to 7.5 adds the honeysuckle of step 4Extract, mixes, and merges with the mixed liquid of step 6, mix, then after charcoal treatment, refrigeration, embedding, sterilizing,Obtain described Chinese medicine composition.
Detailed description of the invention ten: present embodiment is different from detailed description of the invention nine: take by weight in step 1Following component: 1.1～1.50 parts of cholic acid, 1.4～1.8 parts of hyodesoxycholic acids, 1.8～2.4 parts of scutellosides, cape jasmine 10～1270～96 parts of part, 10～12 parts of Cornu Bubali powders, 18～24 parts of mother-of-pearls, 30～42 parts of honeysuckles and Radix Isatidis. OtherIdentical with detailed description of the invention nine
Detailed description of the invention 11: present embodiment is different from detailed description of the invention nine: claim by weight in step 1Take off row component: 1.3～1.50 parts of cholic acid, 1.6～1.8 parts of hyodesoxycholic acids, 2.2～2.4 parts of scutellosides, cape jasmine 10～80～96 parts of 12 parts, 10～12 parts of Cornu Bubali powders, 22～24 parts of mother-of-pearls, 34～42 parts of honeysuckles and Radix Isatidis.Other is identical with detailed description of the invention nine
Detailed description of the invention 11: present embodiment is different from detailed description of the invention nine: claim by weight in step 1Take off row component: 1.3～1.50 parts of cholic acid, 1.6～1.8 parts of hyodesoxycholic acids, 2.2～2.4 parts of scutellosides, cape jasmine 10～80～96 parts of 12 parts, 10～12 parts of Cornu Bubali powders, 22～24 parts of mother-of-pearls, 34～42 parts of honeysuckles and Radix Isatidis.Other is identical with detailed description of the invention nine
Detailed description of the invention 12: present embodiment is different from detailed description of the invention nine: claim by weight in step 1Take off row component: 1.4～1.50 parts of cholic acid, 1.7～1.8 parts of hyodesoxycholic acids, 2.3～2.4 parts of scutellosides, cape jasmine 10～85～96 parts of 12 parts, 10～12 parts of Cornu Bubali powders, 23～24 parts of mother-of-pearls, 38～42 parts of honeysuckles and Radix Isatidis.Other is identical with detailed description of the invention nine
Detailed description of the invention 13: a kind of Chinese traditional medicine composition by the treatment rhinitis described in detailed description of the invention one of present embodimentThe method of preparing collunarium of thing, it is to be by the extract of the Chinese medicine composition of detailed description of the invention one and quality percentage composition0.9% physiological saline obtains liquid collunarium after mixing.
Content of the present invention is not limited only to the content of the respective embodiments described above, the combination of one of them or several detailed description of the invention withSample also can be realized the object of invention.
Verify beneficial effect of the present invention by following examples:
Embodiment mono-:
The preparation method of a kind of Chinese medicine composition for the treatment of rhinitis of the present embodiment, it carries out according to following steps:
Get 1.04～1.56 parts of cholic acid, 1.2～1.8 parts of hyodesoxycholic acids, 1.6～2.4 parts of scutellosides, 8～12 parts of cape jasmines,8～12 parts of Cornu Bubali powders, 16～24 parts of mother-of-pearls, 28～42 parts of honeysuckles, 64～96 parts of Radix Isatidis;
By Radix Isatidis boiling secondary, each 1 hour, collecting decoction, filtered, and filtrate is concentrated into 200ml, adds ethanolMake to reach 60% containing alcohol amount, refrigeration, filters, and filtrate recycling ethanol, adds water, and refrigerates for subsequent use;
Cape jasmine boiling secondary, 1 hour for the first time, 0.5 hour for the second time, collecting decoction, filtered, and filtrate is concentrated into25ml, adds ethanol and makes to reach 60% containing alcohol amount, and refrigeration, filters, and filtrate recycling ethanol, adds water, and refrigerates for subsequent use;
Honeysuckle boiling secondary, each 0.5 hour, collecting decoction, filtered, and filtrate is concentrated into 60ml, adds ethanolMake to reach 75% containing alcohol amount, filter, filtrate regulates pH value to 0.8, and ethanol is reclaimed in refrigeration, then adds ethanol and make to contain alcohol amount and reach85%, refrigeration, filters, and filtrate recycling ethanol, adds water, and refrigerates for subsequent use;
For Cornu Bubali powder, barium hydroxide solution, Concha Margaritifera powder are hydrolyzed respectively 7～9 hours with sulfuric acid, filter, and merging filtrate,Regulate pH value to 3.5～4.0, filter, filtrate adds ethanol to be made to reach 60% containing alcohol amount, and refrigeration, filters, filtrate recycling ethanol,Add water, refrigerate for subsequent use;
After cape jasmine liquid, Radix Isatidis liquid and cornu bubali, mother-of-pearl hydrolysis mixed liquor is merged, be added to cholic acid, hyodesoxycholic acidIn 75% ethanolic solution, mix, add ethanol and make amount of alcohol reach 75%, regulate pH value to 7.0, refrigeration, filters filtrateReclaim ethanol, add water, refrigerate for subsequent use;
Scutelloside dissolves with water for injection, and adjust pH to 7.5 adds Flos Lonicerae extractive solution, mixes, with above-mentioned each for subsequent useLiquid merges, and mix, and inject water to 1000ml, then after charcoal treatment, refrigeration, embedding, sterilizing, to obtain final product.
The Chinese medicine composition of the present embodiment is applicable to nasal obstruction, rhinalgia, the nasal sinus place tenderness that acute or chronic rhinitis, nasosinusitis cause,Nasal membrane ulcer, has a bad nose, sneezes, and the diseases such as dizziness, headache.
Embodiment bis-:
The present embodiment is different from embodiment mono-: said composition is by cholic acid 1.3g, hyodesoxycholic acid 1.5g, scutelloside2g, cape jasmine 10g, Cornu Bubali powder 10g, mother-of-pearl 20g, honeysuckle 35g, Radix Isatidis 80g make. Other concrete method for makingWith embodiment mono-.
The Chinese medicine composition of the present embodiment is applicable to nasal obstruction, rhinalgia, the nasal sinus place tenderness that acute or chronic rhinitis, nasosinusitis cause,Nasal membrane ulcer, has a bad nose, sneezes, and the diseases such as dizziness, headache.
Be that 0.9% physiological saline mixes by the extract of Chinese medicine composition Chinese medicine composition of the present invention and quality percentage compositionAfter, obtain liquid collunarium and carry out clinical analysis.
Using method: by the liquid collunarium making, washing nose every day 2 times, 10 days is a course for the treatment of.
For proving the curative effect of medicine of the present invention, get 180 routine patients, the age is 8～50 years old, is acute and chronic through clinical diagnosisRhinitis, clinical cardinal symptom is nasal obstruction, rhinalgia, nasal sinus place tenderness, nasal membrane ulcer, has a bad nose, sneezes, headThe diseases such as dizzy, headache.
180 patients are divided into four groups at random, are respectively:
A organizes 60 patients, the Chinese medicinal tablet of oral other conventional treatment rhinitis. Every day 2 times, each 2.
B organizes 60 patients, the nasal liquid medicament of nasion instillation embodiment 1, every day 2 times.
C organizes 60 patients, nasal cavity instillation physiological saline, twice of every day.
Experimental result is as follows:
From upper Biao Ke get: A group, there were significant differences (P < 0.05) with B group, shows that the Chinese medicine composition nasal cavity in the present invention dripsNote treatment rhinitis successful is better than oral other Chinese patent drugs. Two groups of A, B all have significant difference (P < 0.05) with C group,Show that all there is certain therapeutic action A, B side to rhinitis, and C is without therapeutic action.
Model case one
Single certain, female, 32 years old, people from Harbin, Heilongjiang Province. Symptom: normal one-sided nasal obstruction, with the symptom of sneezing,With nose heave, have yellow tears morning in nasal cavity, and thickness, and breathing has some setbacks, and nasal sound weight while speaking is rhinitis chronic after diagnosing.
Sick age: 2 years. Examine the time: on January 20th, 2012; Use Chinese medicine composition nasal cavity of the present invention to instil and treat,Every day 2 times. Medication same day, sensation nasal obstruction alleviates, and breathes comparatively unobstructed. Use 10 days, nasal obstruction symptom is not obvious, beatsSneeze number of times obviously reduces. Use after 20 days, nasal mucus amount obviously reduces, and yellow tears transfer tears clearly to. After continuing to use 10 days,Nasal cavity is unobstructed, breathes freely, and malaise symptoms disappears, and has no adverse reaction during this time.
Model case two
Xu certain, man, 35 years old, people from Wangkui County, Heilongjiang Province. Symptom: often nasal obstruction, dizziness, nose is itched, pharyngealSuitable, large a little trace of blood of being with of snivel amount. Be rhinitis after diagnosing. Used other Chinese patent drugs for treatment, DeGrain. Sick age:3 years. Examine the time: on March 21st, 2013; Use Chinese medicine composition nasal cavity of the present invention to instil and treat, every day 2 times.Medication same day, dizzy symptom alleviates. Use 10 days, nasal obstruction symptom disappears substantially, and pharyngeal uncomfortable disappearance, is with blood in nasal mucusSymptom obviously reduces. Use after 20 days, only play even have nasal obstruction symptom, other transference cures morning. Continue medication after 10 days,Malaise symptoms disappears. Drug withdrawal is so far without recurrence.
Model case three
Wang, female, 42 years old, people from Qiqihaer City of Heilongjiang Province. Symptom: nasal obstruction for a long time, snivel, rhiocnesmus, throatDiscomfort, with light inflammation, hyposmia, repeatedly, effect is all undesirable in treatment. Sick age: 9 months. Examine the time:On January 3rd, 2014. Use Chinese medicine composition nasal cavity of the present invention to instil and treat, every day 2 times. Medication same day, runny nose diseaseShape alleviates, and nasal obstruction occurs once in a while; Use after 10 days, except having a stuffy nose once in a while, all other malaise symptoms disappear, and continue to makeWith after 10 days, transference cure, recovery from illness.
Result for the treatment of analysis show to adopt liquid collunarium its efficient be 100%, cure rate is 85%.
Claims (10)
1. a Chinese medicine composition for the treatment of rhinitis, is characterized in that: it comprises the bulk drug of following parts by weight: cholic acid1.04～1.56 parts, 1.2～1.8 parts of hyodesoxycholic acids, 1.6～2.4 parts of scutellosides, 8～12 parts of cape jasmines, Cornu Bubali powder 8～64～96 parts of 12 parts, 16～24 parts of mother-of-pearls, 28～42 parts of honeysuckles and Radix Isatidis.
2. a kind of Chinese medicine composition for the treatment of rhinitis according to claim 1, is characterized in that: it comprises following weightThe bulk drug of umber: 1.1～1.50 parts of cholic acid, 1.4～1.8 parts of hyodesoxycholic acids, 1.8～2.4 parts of scutellosides, cape jasmine 10～70～96 parts of 12 parts, 10～12 parts of Cornu Bubali powders, 18～24 parts of mother-of-pearls, 30～42 parts of honeysuckles and Radix Isatidis.
3. a kind of Chinese medicine composition for the treatment of rhinitis according to claim 2, is characterized in that: it comprises following weightThe bulk drug of umber: 1.2～1.50 parts of cholic acid, 1.5～1.8 parts of hyodesoxycholic acids, 2.0～2.4 parts of scutellosides, cape jasmine 10～75～96 parts of 12 parts, 10～12 parts of Cornu Bubali powders, 20～24 parts of mother-of-pearls, 32～42 parts of honeysuckles and Radix Isatidis.
4. a kind of Chinese medicine composition for the treatment of rhinitis according to claim 3, is characterized in that: it comprises following weightThe bulk drug of umber: 1.3～1.50 parts of cholic acid, 1.6～1.8 parts of hyodesoxycholic acids, 2.2～2.4 parts of scutellosides, cape jasmine 10～80～96 parts of 12 parts, 10～12 parts of Cornu Bubali powders, 22～24 parts of mother-of-pearls, 34～42 parts of honeysuckles and Radix Isatidis.
5. a kind of Chinese medicine composition for the treatment of rhinitis according to claim 4, is characterized in that: it comprises following weightThe bulk drug of umber: 1.4～1.50 parts of cholic acid, 1.7～1.8 parts of hyodesoxycholic acids, 2.3～2.4 parts of scutellosides, cape jasmine 10～85～96 parts of 12 parts, 10～12 parts of Cornu Bubali powders, 23～24 parts of mother-of-pearls, 38～42 parts of honeysuckles and Radix Isatidis.
6. a kind of Chinese medicine composition for the treatment of rhinitis according to claim 1, is characterized in that: the Chinese medicine for the treatment of rhinitisComposition can be combined following ingredients: the flower bud of lily magnolia, Rhizoma Belamcandae;
Wherein this Chinese medicine composition is combined in the steps below with the flower bud of lily magnolia, Rhizoma Belamcandae: the flower bud of lily magnolia extracts volatile oil; Rhizoma Belamcandae addsDecocting boils 2 times, and each 1 hour, collecting decoction, filtered, and it is 1.0～1.1 that filtrate is concentrated into relative density; Then to concentratedAfter filtrate in add ethanol to make alcohol content reach 60%, refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; ToIn filtrate, add the water of 2～4 times of amounts, obtain Rhizoma Belamcandae liquid; Flower bud of lily magnolia liquid, Rhizoma Belamcandae liquid are mixed with this Chinese medicine composition, complete.
7. treat a preparation method for the Chinese medicine composition of rhinitis, it is characterized in that it carries out according to following steps:
One, take by weight following component: 1.04～1.56 parts of cholic acid, 1.2～1.8 parts of hyodesoxycholic acids, scutelloside1.6～2.4 parts, 8～12 parts of cape jasmines, 8～12 parts of Cornu Bubali powders, 16～24 parts of mother-of-pearls, 28～42 parts of honeysuckles and64～96 parts of Radix Isatidis;
Two, Radix Isatidis boiling step 1 being taken 2 times, each 1 hour, collecting decoction, filtered, and filtrate is concentratedTo relative density be 1.0～1.1; Then in the filtrate after concentrated, add ethanol to make alcohol content reach 60%, refrigeration at 20 DEG C,Filter, collect filtrate, and reclaim ethanol; To the water that adds 2～4 times of amounts in filtrate, obtain Radix Isatidis liquid;
Three, cape jasmine boiling step 1 being taken 2 times, decocts 1 hour for the first time, decocts for the second time 0.5 hour,Collecting decoction, filters, and it is 1.0～1.1 that filtrate is concentrated into relative density, then in the filtrate after concentrated, adds ethanol that alcohol is containedAmount reaches 60%, and refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; To the water that adds 2～4 times of amounts in filtrate,Cape jasmine liquid;
Four, honeysuckle boiling step 1 being taken 2 times, each 0.5 hour, collecting decoction, filtered, and filtrate is denseBeing reduced to relative density is 1.0～1.1, then in the filtrate after concentrated, adds ethanol to make alcohol content reach 75%, filters, and collects filterLiquid, filtrate regulates pH value to 0.8, and refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol, then add in filtrateEnter ethanol and make alcohol content reach 85%, refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; In filtrate, add 2～4The doubly water of amount, honeysuckle liquid;
Five, saturated barium hydroxide solution hydrolysis 7～9 hours for Cornu Bubali powder step 1 being taken, filters, and collects buffaloThe filtrate of angle powder; The Concha Margaritifera powder that step 1 is taken is used sulphuric acid hydrolysis 7～9 hours, filters, and collects the filtrate of Concha Margaritifera powder;Merge the filtrate of Cornu Bubali powder and the filtrate of Concha Margaritifera powder, must mix filtrate, regulate pH value to 3.5～4.0 of mixing filtrate,Filter, collect filtrate, in filtrate, add ethanol to make alcohol content reach 60%, refrigeration at 20 DEG C, filters, and collects filtrate,And reclaim ethanol; To the water that adds 2～4 times of amounts in filtrate, obtain the mixed liquor of Cornu Bubali powder and Concha Margaritifera powder;
Six, after the mixed liquor of cape jasmine liquid, Radix Isatidis liquid and Cornu Bubali powder and Concha Margaritifera powder is merged, by the mixed liquor after mergingJoin in 75% ethanolic solution of cholic acid, hyodesoxycholic acid, mix, add ethanol and make ethanol content reach 75%, then regulate pHValue is to 7.0, and refrigeration at 20 DEG C, filters, and collects filtrate, and reclaims ethanol; To the water that adds 2～4 times of amounts in filtrate,Mixed liquid;
Seven, scutelloside step 1 being taken dissolves with water for injection, and adjust pH to 7.5 adds the honeysuckle of step 4 to carryGet liquid, mix, merge with the mixed liquid of step 6, mix, then after charcoal treatment, refrigeration, embedding, sterilizing, to obtain final productDescribed Chinese medicine composition.
8. the preparation method of a kind of Chinese medicine composition for the treatment of rhinitis according to claim 7, is characterized in that step 1In take by weight following component: 1.1～1.50 parts of cholic acid, 1.4～1.8 parts of hyodesoxycholic acids, scutelloside 1.8～2.4Part, 10～12 parts of cape jasmines, 10～12 parts of Cornu Bubali powders, 18～24 parts of mother-of-pearls, 30～42 parts of honeysuckles and Radix Isatidis70～96 parts.
9. the preparation method of a kind of Chinese medicine composition for the treatment of rhinitis according to claim 7, is characterized in that step 1In take by weight following component: 1.4～1.50 parts of cholic acid, 1.7～1.8 parts of hyodesoxycholic acids, scutelloside 2.3～2.4Part, 10～12 parts of cape jasmines, 10～12 parts of Cornu Bubali powders, 23～24 parts of mother-of-pearls, 38～42 parts of honeysuckles and Radix Isatidis85～96 parts.
10. by a method of preparing collunarium for the Chinese medicine composition for the treatment of rhinitis claimed in claim 1, its feature existsIn by the Chinese medicine composition of claim 1 extract be, after 0.9% physiological saline mixes, to obtain liquid with quality percentage compositionBody collunarium.
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