Summary of the invention
The invention provides a kind of oral liquid and preparation method for the treatment of septicemia; Selected by oral liquid of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, the toxin of pathogen secretion in blood can be removed and suppress germ reproduction, there is effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, improve body's immunity, the septicemia caused for various cause of disease is evident in efficacy, long action time, short treating period, instant effect, safe without toxic side effect, can be widely used in the clinical treatment of septicemia.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat an oral liquid for septicemia, raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Treat a preparation method for the oral liquid of septicemia, comprise following processing step:
(1) get Herba Taraxaci, Radix Angelicae Pubescentis, Herba Lophatheri, Folium Nerviliae fordii, Fructus Ulmus preparatium, Radix Arnebiae (Radix Lithospermi) and Herba Violae decontamination, clean and put into container, add the distilled water of 7-9 times amount, soak after 3-4 hour, boil 2-3 hour, extract; Again add 4-6 times amount distilled water, boil 1-2 hour, extract; Finally add 2-3 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use;
(2) get Semen Arecae and Radix Sophorae Flavescentis decontamination, microwave drying, is placed in mortar and grinds into powder, crosses 200 order fine powders, for subsequent use;
(3) get Radix Cirsii Japonici, Herba Artemisiae Annuae and Caulis Bambusae Germinatus decontamination to clean, smash juice, taking juice is for subsequent use;
(4) get Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Iridis, Ramulus Uncariae Cum Uncis and Radix Gentianae decontamination to clean, dry, add 85% alcoholic solution of 5 times amount, soak 2-3 hour, heating extraction 2 hours, recovered alcohol, filter, by the thick paste of relative density 1.15 ~ 1.25 under filtrate simmer down to 60 DEG C of environment, for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1)-(4), fine powder, juice and thick paste mixing, utilize modern advanced pharmacy science and technology, make oral liquid, be the oral liquid of described treatment septicemia.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Taraxaci: sweet in the mouth, micro-hardship, cold in nature.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Can be used for temperature disease, removing heat from the liver, treatment liver-heat conjunctival congestion and swelling pain, and multi-infection, purulent disease.Modern medicine study confirms, Herba Taraxaci has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus, also has certain bactericidal action to Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature; Return liver, kidney, urinary bladder channel.Modern medicine study confirms, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation.
Semen Arecae: bitter in the mouth, pungent, warm in nature; Return stomach, large intestine channel.Killing insect and eliminating accumulation, the capable water of sending down the abnormal ascending QI, preventing the attack (or recurrence) of malaria.For cestode, ascarid, fasciolopsiasis buski, abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, malaria.Modern medicine study confirms, Semen Arecae infusion has inhibitory action in various degree to dermatophytess such as trichophytons in vitro, and decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action.
Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae): acrid in the mouth, micro-hardship, cold in nature, poison greatly; Return lung meridian.Heat-clearing and toxic substances removing, removing obstruction for relieving pain.Cure mainly influenza, leptospirosis, skin infection pain poison is from the beginning of, scrofula, and cellulitis, chronic osteomyelitis, poisonous snake flood dragon hinders, malicious peak sting.
Herba Lophatheri: sweet in the mouth, light, cold in nature; Enter the heart, kidney two warp.Clearing away heart-fire, heat clearing away and restlessness relieving, diuresis.Control calentura thirsty, vexed, hot urination, stranguria with turbid discharge, erosion of the oral mucosa tongue boil, gingival swelling and pain." the SHENGCAO property of medicine standby will " carries: " expectorant is quenched the thirst, and except part of the body cavity above the diaphragm housing the heart and lungs fire, bright eyes, diuresis, controls nebulousurine, brings down a fever, loose hemorrhoid poison.”
Folium Nerviliae fordii: bitter in the mouth, sweet, property is put down.Clearing away lung-heat to relieve cough, spleen invigorating removing food stagnancy, sedation-analgesia, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For pulmonary tuberculosis cough spitting of blood, bronchitis, infantile malnutrition, infantile pneumonia, psychosis, treating swelling and pain by traumatic injury, stomatitis, acute laryngitis, sore." choosing of Simao, Yunnan Chinese herbal medicine " carries: " dissipating blood stasis for subsidence of swelling, sedation-analgesia.Control psychosis, traumatic injury, the swollen stasis of blood pain of knot.”
Ramulus Uncariae Cum Uncis: sweet in the mouth, cool in nature; Return liver, pericardium channel.Heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension." book on Chinese herbal medicine is newly organized " carries: " Ramulus Uncariae Cum Uncis, goes wind very fast, has wind disease person to use it.But the life of wind-fire, many because of in deficiency of kidney-YIN, so that wooden dryness-fire is scorching, in YIN-tonifying drug, use Ramulus Uncariae Cum Uncis less, then wind-fire is fugitive, if complete not nourishing YIN, pure Ramulus Uncariae Cum Uncis is loose fiery to dispel the wind, then wind can not cease, and fiery and more vehement.”
Semen Iridis: sweet in the mouth, property is put down.Heat-clearing and toxic substances removing, hemostasis.Cure mainly jaundice, dysentery, leucorrhea, carbuncle, sore throat, furuncle and phyma, anemofrigid-damp arthralgia, spit blood, epistaxis, the diseases such as metrorrhagia.
Fructus Ulmus preparatium: acrid in the mouth, property is put down.Parasite killing, removing food stagnancy.Cure mainly abdominal pain due to worm stagnation, children's's infantile malnutrition with diarrhea, cold-dysentery, scabies, malignant boil.Modern medicine study confirms, Fructus Ulmus preparatium immersion (1:2) has inhibitory action in various degree to 12 kinds of dermatophytess such as trichophyton, Microsporon audouini in vitro.
Radix Cirsii Japonici: sweet in the mouth, hardship, cool in nature, nontoxic; GUIXIN, Liver Channel.Cure mainly haematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, acute appendicitis, carbuncle and ulcer toxic swelling, furuncle.Modern medicine study confirms, the aqueous solution of Radix Cirsii Japonici has anesthetic action; The generation of Radix Cirsii Japonici to thrombokinase has facilitation, and can suppress pathogenic bacteria generation.
Radix Arnebiae (Radix Lithospermi): sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel.Removing heat from blood and promoting blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Modern medicine study confirms, Radix Arnebiae (Radix Lithospermi) has extremely slight inhibitory action to acute lymphoblastic leukemia.
Herba Artemisiae Annuae: bitter in the mouth, pungent, cold in nature; Return liver, gallbladder meridian, three burnt, kidney channels.Clear deficiency-heat thoroughly, removing heat from blood removes and steams, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.Modern medicine study confirms, Herba Artemisiae Annuae has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, also has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc.
Radix Gentianae: bitter in the mouth, cold in nature; Return liver, gallbladder meridian.Heat clearing away eliminating pathogen in the liver, arresting convulsion.For jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, the feeling of fullness in the head headache of liver and gall excess-fire, conjunctival congestion and swelling pain, deaf ear swells, hypochondriac pain bitter taste, calentura convulsion with spasms.
Caulis Bambusae Germinatus: sweet in the mouth, cold in nature.To reduce phlegm relieving distension.For rash, long-pending abdominal distention, varioliform exanthema does not go out." detailed outline is picked up any lost article from the road " carries, and " reduce phlegm saliva for sharp nine orifices, promoting blood circulation, helps digestion swollen.”
Herba Violae: bitter in the mouth, pungent, cold in nature; GUIXIN, Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature; Return liver, kidney, large intestine, small intestinal, the heart, urinary bladder channel.Heat clearing and damp drying, parasite killing diuresis.Be widely used in multiple humidifier fever, as damp-heat dysentery; External can decoct soup washout, for hemorrhoid, and women gynecological; Modern medicine study confirms, Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus, and Radix Sophorae Flavescentis water logging agent has inhibitory action to trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly difficult to understand little spore tinea bacterium etc.
The present invention compared with prior art, has following beneficial effect:
Selected by oral liquid of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, the toxin of pathogen secretion in blood can be removed and suppress germ reproduction, there is effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, improve body's immunity, the septicemia caused for various cause of disease is evident in efficacy, long action time, short treating period, instant effect, safe without toxic side effect, can be widely used in the clinical treatment of septicemia.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The preparation method of oral liquid of the present invention, comprises following processing step:
(1) get Herba Taraxaci, Radix Angelicae Pubescentis, Herba Lophatheri, Folium Nerviliae fordii, Fructus Ulmus preparatium, Radix Arnebiae (Radix Lithospermi) and Herba Violae decontamination, clean and put into container, add the distilled water of 7-9 times amount, soak after 3-4 hour, boil 2-3 hour, extract; Again add 4-6 times amount distilled water, boil 1-2 hour, extract; Finally add 2-3 times amount distilled water, heated and boiled 1-2 hour, extract; Merge three extracting solution, filter, obtain filtrate for subsequent use;
(2) get Semen Arecae and Radix Sophorae Flavescentis decontamination, microwave drying, is placed in mortar and grinds into powder, crosses 200 order fine powders, for subsequent use;
(3) get Radix Cirsii Japonici, Herba Artemisiae Annuae and Caulis Bambusae Germinatus decontamination to clean, smash juice, taking juice is for subsequent use;
(4) get Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Iridis, Ramulus Uncariae Cum Uncis and Radix Gentianae decontamination to clean, dry, add 85% alcoholic solution of 5 times amount, soak 2-3 hour, heating extraction 2 hours, recovered alcohol, filter, by the thick paste of relative density 1.15 ~ 1.25 under filtrate simmer down to 60 DEG C of environment, for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1)-(4), fine powder, juice and thick paste mixing, utilize modern advanced pharmacy science and technology, make oral liquid, be the oral liquid of described treatment septicemia.
Usage and dosage: oral, each 20ml, every day 3 times, within 7 days, be a course for the treatment of, 3 to 4 courses for the treatment of can fully recover; The person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of oral liquid effective ingredient of the present invention and weight are:
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the oral liquid for the treatment of septicemia, select septic patient 85 example to carry out clinical observation, patient is divided into two groups at random, treatment group 43 example, wherein man 23 example, women 20 example, age 0-60 year, 32.5 years old mean age, disease time 1-15 days; Matched group 42 example, wherein man 21 example, women 21 example, age 0-60 year, 31.8 years old mean age, course of disease 1-15 days; Two groups of patient medical record are basically identical, without significant difference, have comparability, keep on a diet all on request for two groups.
2, Therapeutic Method:
Patient for treatment group applies oral liquid of the present invention, oral, each 20ml, every day 3 times, within 7 days, is a course for the treatment of, and taking 3 to 4 courses for the treatment of continuously can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
The patient of matched group applies penicillin, gives the symptomatic treatments such as warming, oxygen supply, vasoactive drug simultaneously.By specification use, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, Outcome measure:
Cure: the septicemia transference cures such as shiver with cold, high heat, tachycardia, rapid breathing, erythra, arthralgia and hepatosplenomegaly, body immune function improves.
Take a turn for the better: above-mentioned symptom alleviates to some extent, and body immune function increases.
Invalid: symptom is unchanged.
4, therapeutic outcome:
Treatment group: cure 33 examples, take a turn for the better 8 examples, and invalid 2 examples, cure rate is 76.7%, and total effective rate is 95.3%.
Matched group: cure 19 examples, take a turn for the better 11 examples, and invalid 12 examples, cure rate is 45.2%, and total effective rate is 71.4%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
5, model case citing:
(1) Lee, man, 20 years old, university students, Distributions in Liaocheng of Shandong Province people.Patient is admitted to hospital because of nose face ache, and on the right side of patient, mound shape protuberance appears in the wing of nose, and because repeatedly extruding occurs that upper lip Face and cheek is red and swollen, tenderness is positive, with low grade fever.AD is that boil of the nose merges buccal cellulitis, give antiinflammatory symptomatic treatment, occur high heat, headache next day, body temperature 40 DEG C ~ 41 DEG C, patient's mind is indifferent, drowsiness, Ipsilateral eyelid and conjunctiva are without edema, and papilla of optic nerve is without edema, numeration of leukocyte is 3.1 × 109/L, blood antibacterial culturing is infection of staphylococcus aureus, after be diagnosed as the concurrent septicemia of boil of the nose, proceed to medical treatment.Give a large amount of antibiotic, induced hibernation, adrenocortical hormone do not feel any better, occur that pulse is thin and delicate, rapid breathing, hepatosplenomegaly.Rear patient uses oral liquid of the present invention, takes 4 courses for the treatment of, and recovery from illness, has no recurrence.
(2) Xu certain, female, people from Changzhi, Shanxi.Raw latter 7 days of patient, body weight is about 2.5kg, Low Response, does not take food, and does not cry, Dermal icterus, and complexion is steel gray, and Face and cheek, buttocks and two upper and lower extremities lateral cutaneous harden, and can not pinch, and have pitting edema, hepatosplenomegaly with hands, and heart rate is slow, and hear sounds is low blunt, and body temperature does not rise.Blood routine examination total white blood cells reduces, and 4 × 10g/L, neutrophilic granulocyte band form nucleus 21%, c reactive protein increases, and is diagnosed as septicemia of newborn.After taking 3 courses for the treatment of of oral liquid of the present invention, recovery from illness, has no recurrence.
(3) poplar, man, 32 years old, workman, Pingliang, Gansu people.There is heating without obvious inducement in patient, body temperature fluctuation is in 38 DEG C ~ 39 DEG C, and with headache, Nausea and vomiting, have a blood test conventional WBC19 × 10g/L, N86.3% in locality; Waist is worn CSF and is checked: cranium pressure 200mmH2O, sugar, albumen slightly raise, and chloride is lower slightly, and respiratory rhythm is obviously accelerated, and two pulmonary respiration sound is thick.Clinical diagnosis is septicemia, and after patient takes oral liquid of the present invention 3 course of therapy, conditions of patients is fully recovered.
(4) together certain, man, 46 years old, businessman, Tianjin Nankai people from district.Patient is admitted to hospital because of heating, double knee joint and waist and sacrum pain, and body temperature is between 38 DEG C ~ 40 DEG C, and the performance that No respiratory infects, urine, feces are as usual, without skin infection history.Passive flexing position when coming institute, anemia, skin, mucosa have no petechia, superficial lymph knot does not touch, conjunctiva is pale, and the heart, lung check no abnormality seen, and the liver upper bound is at right midclavicular line the 6th intercostal, lower bound is 2cm under rib, matter is soft, and spleen does not touch, and clinical diagnosis is septicemia, after patient takes oral liquid of the present invention 3 course of therapy, conditions of patients is fully recovered.