CN107050395B - Traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and preparation method and application thereof - Google Patents
Traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and preparation method and application thereof Download PDFInfo
- Publication number
- CN107050395B CN107050395B CN201710386049.9A CN201710386049A CN107050395B CN 107050395 B CN107050395 B CN 107050395B CN 201710386049 A CN201710386049 A CN 201710386049A CN 107050395 B CN107050395 B CN 107050395B
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- traditional chinese
- chinese medicine
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 100
- 238000002360 preparation method Methods 0.000 title claims abstract description 52
- 206010037660 Pyrexia Diseases 0.000 title claims abstract description 43
- 210000001599 sigmoid colon Anatomy 0.000 title claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 229910052602 gypsum Inorganic materials 0.000 claims abstract description 16
- 239000010440 gypsum Substances 0.000 claims abstract description 16
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 14
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 14
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 14
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 14
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 14
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 14
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 14
- 235000007519 Chimonanthus praecox Nutrition 0.000 claims abstract description 12
- 241000931705 Cicada Species 0.000 claims abstract description 12
- 240000007126 Citrus medica var. sarcodactylis Species 0.000 claims abstract description 12
- 240000001359 Origanum dictamnus Species 0.000 claims abstract description 12
- 235000015987 Origanum dictamnus Nutrition 0.000 claims abstract description 12
- 235000004383 Origanum vulgare subsp. vulgare Nutrition 0.000 claims abstract description 12
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 11
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 8
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 8
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 7
- 244000164480 Curcuma aromatica Species 0.000 claims abstract description 7
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 7
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 7
- 235000011477 liquorice Nutrition 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 45
- 239000007788 liquid Substances 0.000 claims description 21
- 229940079593 drug Drugs 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 12
- 239000002244 precipitate Substances 0.000 claims description 12
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 244000236521 Bupleurum rotundifolium Species 0.000 claims description 5
- 235000015221 Bupleurum rotundifolium Nutrition 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- 235000002555 Citrus medica var sarcodactylis Nutrition 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 7
- 244000299790 Rheum rhabarbarum Species 0.000 claims 2
- 241000050051 Chelone glabra Species 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 19
- 206010067484 Adverse reaction Diseases 0.000 abstract description 6
- 230000006838 adverse reaction Effects 0.000 abstract description 6
- 230000036760 body temperature Effects 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 abstract description 6
- 238000001802 infusion Methods 0.000 abstract description 4
- 240000004980 Rheum officinale Species 0.000 abstract description 3
- 235000008081 Rheum officinale Nutrition 0.000 abstract description 3
- 230000004044 response Effects 0.000 abstract description 3
- 241000700605 Viruses Species 0.000 description 15
- 230000014759 maintenance of location Effects 0.000 description 11
- 208000011580 syndromic disease Diseases 0.000 description 11
- 241000219061 Rheum Species 0.000 description 9
- 210000000664 rectum Anatomy 0.000 description 8
- 241000792859 Enema Species 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000007920 enema Substances 0.000 description 7
- 229940095399 enema Drugs 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 241000207929 Scutellaria Species 0.000 description 4
- 210000000436 anus Anatomy 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 235000008216 herbs Nutrition 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 238000010926 purge Methods 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 206010057190 Respiratory tract infections Diseases 0.000 description 3
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000001754 anti-pyretic effect Effects 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 230000000112 colonic effect Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- 241000202726 Bupleurum Species 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 240000004534 Scutellaria baicalensis Species 0.000 description 2
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 210000001163 endosome Anatomy 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229920002477 rna polymer Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000015815 Rectal disease Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 210000002255 anal canal Anatomy 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000009254 shuang-huang-lian Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and a preparation method and application thereof. The preparation is prepared from the following raw materials in parts by weight: 4-8 parts of kudzu root, 4-8 parts of radix bupleuri, 8-12 parts of radix scutellariae, 12-18 parts of gypsum, 2-4 parts of rheum officinale, 4-8 parts of cape jasmine, 4-8 parts of curcuma zedoary, 8-12 parts of wintersweet leaf, 10-12 parts of fingered citron, 4-6 parts of cicada slough and 2-4 parts of liquorice. The traditional Chinese medicine sigmoid colon infusion preparation for treating infantile exogenous fever has the characteristics of quick response, good curative effect, difficult rebound at body temperature, obvious relief of accompanying symptoms, small adverse reaction and the like when being used for treating infantile exogenous fever, and has better effect on wind-heat clamping stagnation type.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever as well as a preparation method and application thereof.
Background
The infantile exogenous fever is equivalent to the upper respiratory tract infection and influenza category of western medicine, and the incidence rate accounts for the first pediatric diseases. The pathogens are mainly viruses and can account for more than 90 percent of the primary upper respiratory tract infection. The virus is the smallest of pathogenic microorganisms, the core of the virus is ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), the outer shell of the virus is protein, the virus does not have a cellular structure, most of the virus lacks an enzyme system, the virus cannot live independently, and the virus can be propagated (replicated) only by being integrated into a host cell depending on the enzyme system of the host. Thus, antiviral agents are in a sense only viral inhibitors and are not able to kill viruses and destroy virions directly, or otherwise damage host cells. Therefore, the curative effect of the current antiviral western medicine cannot be determined, and the current antiviral western medicine has larger side effect. At present, the treatment of upper respiratory tract infection internationally mainly comprises rest, symptomatic treatment and complication prevention, and antipyretic analgesics are advocated when the fever exceeds 38.5 ℃, but because viruses are not effectively controlled, the body temperature is mostly repeatedly raised after a plurality of hours, great discomfort is caused to children patients, or convulsion is induced.
The traditional Chinese medicine has systematic theoretical research and abundant clinical experience for dialectically treating the exogenous fever of the children, emphasizes the difference between individuals and syndrome types, treats the exogenous fever according to differentiation of syndromes of local, time and people, has definite curative effect, and has low price and small toxic and side effect. However, the traditional Chinese medicine decoction is difficult to feed due to poor taste of the decoction and the phenomenon of vomiting and refusal of the medicine occurs when the sick children are young. Many Chinese patent medicines are also published, including oral and injection preparations, such as Shuanghuanglian oral liquid and injection, Xiao Chaigui defervesce oral liquid and the like, but the Chinese patent medicines cannot fully reflect the concept of treatment based on syndrome differentiation, and the clinical curative effect of the Chinese patent medicines is obviously inferior to that of the traditional Chinese medicine decoction pieces. The above varieties seriously hinder the clinical popularization and application of the traditional Chinese medicine. The traditional Chinese medicine external treatment method solves the problems that children are afraid of taking medicines and injection and are afraid of pain, has definite curative effect and is advocated by medical staff and parents. The traditional Chinese medicine external treatment methods commonly used in clinic include medicine application, massage and spinal kneading, enema, acupuncture and moxibustion and the like, and in recent years, the traditional Chinese medicines rectal instillation and sigmoid colonic instillation are increasingly popular as a novel administration way.
Sigmoid administration is therapeutic by infusing the drug into the sigmoid via the anus. The traditional transanal administration adopts a retention enema mode, most of the retention enema modes are random operations without normative requirements, the retention enema is generally finished by injecting into rectum, and the retention time is short or small, so the retention enema is generally only limited to treating anorectal diseases or pelvic cavity and lower abdominal diseases. Sigmoid colonic instillation is developed from retention enema and rectal instillation, can control the speed of liquid medicine instillation, has slow administration speed, does not accumulate too much in intestinal tract quickly to cause defecation and discharge, and has much less stimulation to anus and rectum than retention enema. The drip administration of the traditional Chinese medicine rectum can ensure that the liquid medicine is uniformly dispersed on the surface of the rectal mucosa and dissolved in secretions, and then is fully absorbed, most of the liquid medicine enters the major circulation through the middle and lower veins of the rectum and the anal canal vein, so the first pass effect of the liver is avoided, in addition, the rectal administration is faster than the oral administration and is similar to the intravenous administration, the difficulty of oral administration of children and the influence of the upper gastrointestinal enzymolysis and acidolysis on orally taken medicines are also avoided, and the bioavailability of the medicine is improved. Therefore, clinical research and experimental research aiming at rectal instillation administration are more, but with the continuous and deep research, many defects are exposed, such as obvious rectal administration convenience, sensitive liquid medicine temperature and administration speed, discomfort for sick children and reduced compliance of the sick children; the rectum section is short, the liquid medicine is easy to leak out, the drip tube is easy to slide out, and the operation difficulty is increased, so that the sick children and family members thereof feel boring; small rectal space, and the dosage and administration speed are not easy to master. The sigmoid colon is the intersection of the colon and the rectum, has the physiological function characteristics of the rectum and the colon, has mild pH condition and less metabolic enzyme, and can improve the stability of the medicine; the drug has large capacity, has lower requirements on the dosage, the administration speed and the temperature, has longer running time in the colon than in the rectum, can increase the absorption of the drug and improve the bioavailability of the drug; the deeper part can overcome the defects of easy exudation of the liquid medicine, easy sliding of the drip chamber, strong defecation sense of the sick children and the like. In addition, the exogenous febrile disease is in the lung defense, the lung and the large intestine are exterior and interior, and the traditional Chinese medicine sigmoid colon drip is adopted to ensure that the efficacy of the medicine reaches the lung defense along the channels to eliminate pathogenic factors and reduce fever, thereby achieving the purpose of treating the internal disease by external therapy. This is the specific embodiment of the treatment of pediatrics in TCM, namely "lower-lying upper diseases" and "six fu-organs are used for general purpose".
According to traditional Chinese medicine, the exogenous fever of children is mainly caused by wind evil, and is divided into wind cold and wind heat. Clinically, wind-heat syndrome is the most common syndrome because children are the body of shaoyang disease and are prone to heat transformation after being infected with pathogens. The frequent insufficiency of the spleen in children usually affects the transportation and transformation functions of children, and sometimes causes the retention of milk and food, the obstruction of the middle energizer, the abdominal distention and fullness, poor appetite and other symptoms of exogenous pathogenic factors with stagnation. The body of shaoyang children is easy to be transformed into heat after being attacked by pathogenic factors, and is quick to be transmitted and changed, so that the exogenous pathogenic factors of the children are often not characterized and the interior symptoms appear again, and most of the three symptoms of taiyang, yangming and shaoyang are complicated in treatment. The three-yang clearing and resolving liquid is derived from ChaoGe Jieji Tang from Shang Han six Books, and Dachaihu Tang and Baihu Tang from Shang Han miscellaneous diseases, based on the syndrome differentiation theory of six meridians from Zhongjing Shang Han Lun. Wherein the root of kudzu vine is pungent and cool to release exterior and enter the sun; the bupleurum root, radix bupleuri, the scutellaria root, the radix scutellariae, the radix bupleuri, the radix scutellariae, the radix; gypsum, Gypsum Fibrosum, radix et rhizoma Rhei, fructus Gardeniae, radix Et rhizoma Rhei, radix Glycyrrhizae, radix rehmanniae Preparata, fructus Gardeniae, radix Et rhizoma Rhei, fructus Gardeniae, radix Et rhizoma Rhei. The whole formula has the effects of pungent and cool for relieving exterior syndrome, regulating Shaoyang and clearing and purging yangming. According to modern researches, the radix bupleuri, the radix scutellariae, the cape jasmine and the rhubarb have the functions of inhibiting viruses and bacteria, relieving fever and resisting inflammation, and the radix puerariae and the gypsum have good relieving fever functions. The most wonderful formula is added with the zedoary, which has the following four: it can promote blood circulation to dissipate blood stasis and promote the absorption of the medicine; the dual-purpose of the utility model can eliminate food retention and promote qi circulation, thus enhancing the appetite of children patients; thirdly, taking the property of bitter, warm, pungent and dispersed herbs to assist the cold and cool nature of the herbs; and the volatile oil of the medicine is taken to inhibit viruses and bacteria and enhance immunity, thereby comprehensively improving the curative effect of the medicine.
At present, the three-yang clearing decoction sigmoid colon infusion is used for treating the best indication of the infantile exogenous fever, the best medicine compatibility, the best depth of the entering of an intestinal drip tube, the best temperature of liquid medicine, the best infusion speed and the like, but the experiences are mature, but the experiences on the aspects of the influence of the osmotic pressure, the pH value and the like of the liquid medicine on the human body and the like do not exist.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and a preparation method and application thereof.
The technical scheme of the invention is as follows:
a traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever is prepared from the following raw materials in parts by weight: 4-8 parts of kudzu root, 4-8 parts of radix bupleuri, 8-12 parts of radix scutellariae, 12-18 parts of gypsum, 2-4 parts of rheum officinale, 4-8 parts of gardenia, 4-8 parts of curcuma zedoary, 8-12 parts of wintersweet leaf, 8-12 parts of fingered citron, 4-6 parts of cicada slough and 2-4 parts of liquorice.
Preferably, the traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever is prepared from the following raw materials in parts by weight: 5.5 to 6.5 parts of kudzuvine root, 5.5 to 6.5 parts of Chinese thorowax root, 9 to 11 parts of baical skullcap root, 13.5 to 16.5 parts of gypsum, 2.5 to 3.5 parts of rhubarb, 5.5 to 6.5 parts of cape jasmine fruit, 5.5 to 6.5 parts of zedoary, 9 to 11 parts of wintersweet leaf, 9 to 11 parts of finger citron, 4.5 to 5.5 parts of cicada slough and 2.5 to 3.5 parts of liquoric root.
Preferably, the traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever is prepared from the following raw materials in parts by weight: 6 parts of kudzu root, 6 parts of radix bupleuri, 10 parts of radix scutellariae, 15 parts of gypsum, 3 parts of rhubarb, 6 parts of cape jasmine, 6 parts of curcuma zedoary, 10 parts of wintersweet leaf, 10 parts of fingered citron, 5 parts of cicada slough and 3 parts of liquorice.
Further, the preparation contains crude drug 0.06-0.1 g/mL, preferably 0.08 g/mL.
The traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever has the functions that: pungent and cool to relieve exterior syndrome, harmonize Shaoyang, clear and purge Yangming, promote digestion and resolve phlegm; the main treatment is as follows: fever caused by exogenous pathogens in children is manifested by severe fever, slight aversion to cold, tidal fever in the afternoon or alternating chills and fever, sweating, thick nasal discharge, cough, yellow phlegm, red and swollen throat, dry and thirst mouth, abdominal distention, anorexia, feverish sensation in the palms and soles, foul breath or vomiting, abdominal pain, constipation or diarrhea, red tongue, yellow and greasy coating, slippery and rapid pulse or purple stagnation of fingerprints. The use method comprises the following steps: decocted in water for sigmoid colonic instillation.
The invention relates to a traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever, which is prepared by improving a three-yang clearing decoction formula (6 g of kudzuvine root, 6g of Chinese thorowax root, 10g of baical skullcap root, 15g of gypsum, 3g of rhubarb, 6g of cape jasmine fruit, 6g of zedoary and 3g of liquoric root). In the original three-yang clearing and detoxifying decoction formula, the kudzuvine root is pungent and cool to relieve exterior syndrome and enters the sun; bupleurum root, radix bupleuri; gypsum, Gypsum Fibrosum, radix et rhizoma Rhei, is sweet and cold in nature and can clear heat evil in the yang-qi system; the combination of the kudzuvine root, the Chinese thorowax root and the gypsum is a monarch drug which can clear excess heat of three yang; the scutellaria baicalensis clears away the ministerial fire and relieves shaoyang disease; rhubarb, radix et rhizoma Rhei purges heat, relieves constipation and washes yang-heat in the open bowel; gardenia is bitter and cold and can clear damp-heat in triple energizer; the pungent and warm zedoary can promote qi circulation, remove food retention, break blood and alleviate pain; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe. According to modern researches, radix bupleuri, scutellaria baicalensis, gardenia and rheum officinale have the effects of inhibiting viruses and bacteria, relieving fever and resisting inflammation, and radix puerariae and gypsum have good antipyretic effects. The most wonderful formula is added with the zedoary, which has the following four: it can promote blood circulation to dissipate blood stasis and promote the absorption of the medicine; the dual-purpose of the utility model can eliminate food retention and promote qi circulation, thus enhancing the appetite of children patients; thirdly, taking the property of bitter, warm, pungent and dispersed herbs to assist the cold and cool nature of the herbs; and the volatile oil of the medicine is taken to inhibit viruses and bacteria and enhance immunity, thereby comprehensively improving the curative effect of the medicine.
The wintersweet leaf, the fingered citron and the cicada slough are added on the basis of the original prescription; the wintersweet leaves are pungent and cool, relieve exterior syndrome, clear away heat and toxic materials, and have the effects of resisting bacteria, resisting viruses, relieving fever, easing pain, relieving cough, eliminating phlegm and increasing immunity according to research; the fingered citron enters the liver channel, the spleen channel and the stomach channel and has various medicinal functions of regulating qi, reducing phlegm, stopping vomiting, relieving flatulence, soothing the liver, strengthening the spleen, harmonizing the stomach and the like; cicada slough dissipates wind and removes heat, relieves sore throat, promotes eruption and relieves spasm; the whole formula has the effects of pungent and cool for relieving exterior syndrome, regulating Shaoyang and clearing and purging yangming. The phlegm, food and convulsion are often included in the exogenous fever of the children, and the three medicines are added, so that the antipyretic effect can be enhanced, and the phlegm, food and convulsion accompanied with the exogenous fever of the children can be considered.
Further, the invention also provides a preparation method of the traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever, which comprises the following steps: taking the traditional Chinese medicine raw materials according to the proportion, soaking, decocting, concentrating the liquid medicine, adding ethanol until the ethanol content is 50% (volume content), fully stirring, cooling (generally 0-4 ℃) and filtering, removing precipitates, recovering ethanol from the filtrate until no ethanol smell exists, adding a proper amount of distilled water until the crude medicine raw materials are contained in each mL of the liquid medicine, adjusting the pH value to 6.5-7.5, cooling (generally 0-4 ℃) and filtering, discarding the precipitates, filling and sterilizing to obtain the traditional Chinese medicine composition.
Preferably, the soaking is carried out for 20-40min (preferably 30min) by using cold water (generally 20-30 ℃).
Preferably, decocting for 1-3 times (1-3 hr each time), and adding 8-15 times of water.
Preferably, the drug solution is concentrated to a relative density of 1.10 (measured at 80 ℃).
Preferably, the sterilization is performed by using flowing steam (100 ℃) for 40 min.
Preferably, the traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever further comprises a proper amount of pharmaceutically acceptable preservative, such as sodium benzoate.
Specifically, the preparation method of the traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever comprises the following steps: taking the traditional Chinese medicine raw materials according to the proportion, adding cold water (generally 20-30 ℃) to soak for 0.5h, decocting and extracting for three times with 10 times of water each time, decocting for 1h each time, combining the decoctions, filtering, concentrating the filtrate to relative density of 1.10 (measured at 80 ℃); adding 95% ethanol until ethanol content is 50% (volume content), stirring, cooling (generally 0-4 deg.C) for 48 hr, filtering, removing precipitate, recovering ethanol from filtrate until no alcohol smell is produced, adding appropriate amount of antiseptic (such as sodium benzoate), adding appropriate amount of distilled water to make the solution contain crude drug 0.06-0.1 g/mL, adjusting pH to 6.5-7.5, cooling (generally 0-4 deg.C) for 48 hr, filtering, discarding precipitate, bottling, and sterilizing with flowing steam (100 deg.C) for 40min to obtain the final product.
Through a large number of clinical observations, the invention summarizes the instillation method, the entering depth of the dropper, the temperature of the liquid medicine, the dosage and the instillation speed: connecting a medicine bottle with a disposable transfusion leather strip, then connecting a catheter, ordering the patient to empty the bowels, lying on the left side, lubricating the front end of the catheter with paraffin oil, holding the catheter by a hand, slowly inserting the catheter into the anus through an anus rotating catheter, wherein the medicine temperature is 39-41 ℃, the depth is 20-30cm, the medicine amount is 10ml preparation/Kg body weight, the dripping speed is 1.5-2 ml preparation/min, the dripping speed of the medicine liquid can be properly adjusted according to the age and the tolerance of the patient, the patient feels warm, comfortable and inconvenient to feel in the lower abdomen, gently softening the abdomen for several minutes after dripping is finished, and ordering the patient to continue to keep the lying on the left side for 10 minutes.
The invention also comprises the application of the preparation or the preparation prepared by the method in preparing a medicine for treating infantile exogenous fever.
The traditional Chinese medicine sigmoid colon infusion preparation for treating infantile exogenous fever has the characteristics of quick response, good curative effect, difficult rebound at body temperature, obvious relief of accompanying symptoms, small adverse reaction and the like when being used for treating infantile exogenous fever, and has better effect on wind-heat clamping stagnation type.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
Example 1
A traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever is prepared from the following raw materials in parts by weight: 6 parts of kudzu root, 6 parts of radix bupleuri, 10 parts of radix scutellariae, 15 parts of gypsum, 3 parts of rhubarb, 6 parts of cape jasmine, 6 parts of curcuma zedoary, 10 parts of wintersweet leaf, 10 parts of fingered citron, 5 parts of cicada slough and 3 parts of liquorice.
The preparation method comprises the following steps: taking the traditional Chinese medicine raw materials according to the proportion, adding cold water (20-30 ℃) to soak for 0.5h, decocting and extracting for three times with 10 times of water each time, decocting for 1h each time, combining the decoctions, filtering, and concentrating the filtrate to relative density of 1.10 (measured at 80 ℃); adding 95% ethanol until ethanol content is 50% (volume content), stirring, cooling at 0-4 deg.C for 48 hr, filtering, removing precipitate, recovering ethanol from filtrate until ethanol smell disappears, adding sodium benzoate 3g, adding distilled water to 1000mL (equivalent to 0.08g of crude drug per mL of medicinal liquid), adjusting pH to 6.5-7.5, cooling at 0-4 deg.C for 48 hr, filtering, discarding precipitate, bottling, and sterilizing with flowing steam (100 deg.C) for 40 min.
Example 2
A traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever is prepared from the following raw materials in parts by weight: 8 parts of kudzu root, 8 parts of radix bupleuri, 12 parts of radix scutellariae, 18 parts of gypsum, 4 parts of rhubarb, 8 parts of cape jasmine, 8 parts of curcuma zedoary, 12 parts of wintersweet leaf, 12 parts of fingered citron, 6 parts of cicada slough and 4 parts of liquorice.
The preparation method is the same as example 1.
Example 3
A traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever is prepared from the following raw materials in parts by weight: 4 parts of kudzu root, 4 parts of radix bupleuri, 8 parts of radix scutellariae, 12 parts of gypsum, 2 parts of rhubarb, 4 parts of cape jasmine, 4 parts of curcuma zedoary, 8 parts of wintersweet leaf, 8 parts of fingered citron, 4 parts of cicada slough and 2 parts of liquorice.
The preparation method is the same as example 1.
Comparative example 1
A traditional Chinese medicine sigmoid colon instillation preparation comprises the following formula: 6g of kudzuvine root, 6g of Chinese thorowax root, 10g of baical skullcap root, 15g of gypsum, 3g of rhubarb, 6g of cape jasmine fruit, 6g of zedoary and 3g of liquoric root.
The preparation method is the same as example 1.
Comparative example 2
A traditional Chinese medicine sigmoid colon instillation preparation comprises the following formula: 10g of wintersweet leaf, 10g of finger citron and 5g of cicada slough.
The preparation method is the same as example 1.
Examples of the experiments
30 cases (wind-heat clamping stagnation type) of exogenous febrile children with fever time within 6 hours, body temperature not more than 38.5 ℃ and blood conventional white blood cell count within normal range are observed to be randomly divided into three groups, each group is respectively added with 1 sigmoid colon instillation daily for 1 time and 10ml preparation/Kg body weight on the basis of conventional treatment, and the results of 2 continuous experiments are shown in the following table:
note: in effective cases, A means that the endosome temperature of the infant patient is normal within 36 hours, no rebound occurs within 72 hours, and no obvious adverse reaction occurs; b means that the endosome temperature of the infant patient is normal within 40 hours, no rebound occurs within 72 hours, and no obvious adverse reaction occurs; c means that the body temperature of the infant patient is normal within 48 hours, no rebound occurs within 72 hours, and no obvious adverse reaction occurs.
The experimental results show that: example 1 sigmoid colon instillation preparation for treating infantile exogenous fever has quick response, good curative effect, difficult rebound of body temperature, obvious relief of accompanying symptoms, small adverse reaction and obviously better treatment effect than comparative examples 1 and 2.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (11)
1. A traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 5.5 to 6.5 parts of kudzuvine root, 5.5 to 6.5 parts of Chinese thorowax root, 9 to 11 parts of baical skullcap root, 13.5 to 16.5 parts of gypsum, 2.5 to 3.5 parts of rhubarb, 5.5 to 6.5 parts of cape jasmine fruit, 5.5 to 6.5 parts of zedoary, 9 to 11 parts of wintersweet leaf, 9 to 11 parts of finger citron, 4.5 to 5.5 parts of cicada slough and 2.5 to 3.5 parts of liquoric root;
the preparation method of the preparation comprises the following steps: taking the traditional Chinese medicine raw materials according to the proportion, soaking, decocting, concentrating the liquid medicine, adding ethanol until the ethanol content is 50%, fully stirring, cooling, filtering, removing precipitate, recovering ethanol from the filtrate until no alcohol smell exists, adding a proper amount of distilled water until the content of the raw medicine raw materials is 0.06-0.1g per mL of the liquid medicine, adjusting the pH value to 6.5-7.5, cooling, filtering, removing the precipitate, filling and sterilizing to obtain the traditional Chinese medicine composition.
2. The preparation according to claim 1, which is prepared from the following Chinese medicinal raw materials in parts by weight: 6 parts of kudzu root, 6 parts of radix bupleuri, 10 parts of radix scutellariae, 15 parts of gypsum, 3 parts of rhubarb, 6 parts of cape jasmine, 6 parts of curcuma zedoary, 10 parts of wintersweet leaf, 10 parts of fingered citron, 5 parts of cicada slough and 3 parts of liquorice.
3. The preparation according to claim 1 or 2, wherein the crude drug raw material is contained in an amount of 0.06 to 0.1g per mL of the preparation.
4. The preparation according to claim 3, wherein the crude drug raw material is contained in an amount of 0.08 g/mL of the preparation.
5. The formulation according to claim 1 or 2, further comprising a suitable amount of a pharmaceutically acceptable preservative.
6. The formulation of claim 5, wherein the preservative is sodium benzoate.
7. A method of preparing a formulation as claimed in any one of claims 1 to 6, comprising: taking the traditional Chinese medicine raw materials according to the proportion, soaking, decocting, concentrating the liquid medicine, adding ethanol until the ethanol content is 50%, fully stirring, cooling, filtering, removing precipitate, recovering ethanol from the filtrate until no alcohol smell exists, adding a proper amount of distilled water until the content of the raw medicine raw materials is 0.06-0.1g per mL of the liquid medicine, adjusting the pH value to 6.5-7.5, cooling, filtering, removing the precipitate, filling and sterilizing to obtain the traditional Chinese medicine composition.
8. The preparation method of the preparation according to claim 7, wherein the preparation is soaked in cold water for 20-40 min;
and or, decocting for 1-3 times (1-3 h each time), and adding water 8-15 times of the Chinese medicinal materials each time;
and/or, the liquid medicine is concentrated to the relative density of 1.10;
andor, the sterilization is by flowing steam; sterilizing for 40 min.
9. The method for preparing the formulation according to claim 8, wherein the soaking is performed with cold water for 30 min.
10. The method of preparing the formulation of claim 7, comprising: taking the traditional Chinese medicine raw materials according to the proportion, adding cold water to soak for 0.5h, decocting and extracting for three times with 10 times of water each time, decocting for 1h each time, combining the decoctions, filtering, and concentrating the filtrate to the relative density of 1.10; adding 95% ethanol until ethanol content is 50%, stirring, cooling for 48 hr, filtering, removing precipitate, recovering ethanol from filtrate until no ethanol smell exists, adding appropriate amount of antiseptic, adding appropriate amount of distilled water to make the solution contain crude drug 0.06-0.1g per mL, adjusting pH to 6.5-7.5, cooling for 48 hr, filtering, removing precipitate, bottling, and sterilizing with flowing steam for 40 min.
11. Use of a formulation according to any one of claims 1 to 6 or a formulation prepared by a method according to any one of claims 7 to 10 in the manufacture of a medicament for the treatment of fever from exogenous childhood.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710386049.9A CN107050395B (en) | 2017-05-26 | 2017-05-26 | Traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710386049.9A CN107050395B (en) | 2017-05-26 | 2017-05-26 | Traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107050395A CN107050395A (en) | 2017-08-18 |
| CN107050395B true CN107050395B (en) | 2020-09-15 |
Family
ID=59611134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710386049.9A Active CN107050395B (en) | 2017-05-26 | 2017-05-26 | Traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107050395B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110142964A1 (en) * | 2009-12-10 | 2011-06-16 | Shawn Wells | Increasing athletic performance in humans with ruta chalepensis extract |
-
2017
- 2017-05-26 CN CN201710386049.9A patent/CN107050395B/en active Active
Non-Patent Citations (5)
| Title |
|---|
| 三阳清解散治疗小儿外感发热临床观察;王晓燕;《中国中医急症》;20080430;第17卷(第4期);第453-454页 * |
| 三阳清解煎剂直肠滴注治疗小儿外感发热;王晓燕等;《时珍国医国药》;20071231;第18卷(第04期);第838-840页，尤其是第839页左栏第2.1.1节，第839页右栏末段，第840页左栏第1-2段 * |
| 中药乙状结肠和直肠点滴在儿科临床应用的研究;冯梅等;《四川中医》;20071231;第25卷(第8期);第85-86页，尤其是第85页左栏第1段，第86页右栏末段 * |
| 山蜡梅叶颗粒治疗小儿外感发热疗效观察;王晓燕等;《中外妇儿健康》;20110930;第19卷(第9期);第220-221页 * |
| 柴葛洗剂药浴在小儿外感发热中的降温效果评价;邢英华等;《中国药房》;20110119;第22卷(第03期);第271-273页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107050395A (en) | 2017-08-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102772781B (en) | Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof | |
| CN102784282A (en) | Medicine for clearing heat, removing toxicity and reducing fever | |
| CN104547496B (en) | A kind of Chinese medicine composition to moisten the lung and relieve the cough and preparation method thereof | |
| CN105412749A (en) | Medicine for treating infantile pneumonia with dyspnea and cough and preparation method and application method thereof | |
| CN102847021B (en) | Enema for treating ulcerative colitis and preparation method thereof | |
| CN102274385B (en) | Medicament for treating nasosinusitis and preparation method thereof | |
| CN103585336A (en) | Drug composition for treating acute pharyngitis | |
| CN103920027A (en) | Medicament for treating acute jaundice hepatitis B and preparation method thereof | |
| CN102139051B (en) | Application of soft capsule capable of clearing heat and eliminating toxin in preparation of medicament for treating viral pneumonia | |
| CN104474104A (en) | Traditional Chinese medicine composition for preventing and treating infectious rhinitis of chicken and preparation method thereof | |
| CN103100072B (en) | Traditional Chinese medicine composition for treating proctitis and appendicitis, and restraining rectum cancer | |
| CN107050395B (en) | Traditional Chinese medicine sigmoid colon instillation preparation for treating infantile exogenous fever and preparation method and application thereof | |
| CN108096344A (en) | A kind of Chinese medicine for treating rhinitis composition | |
| CN104352880A (en) | Pharmaceutical composition for treating bacterial infectious cold of dogs and preparation method of pharmaceutical composition | |
| CN106620205A (en) | Externally-used traditional Chinese medicine for foot bath to treat pediatric fever | |
| CN104840902A (en) | Traditional Chinese medicine preparation for treating ovarian tumor | |
| CN104524113A (en) | Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease lung-spleen damp-heat syndrome and nursing method | |
| CN104116960A (en) | Traditional Chinese medicinal preparation for treating hand-foot-and-mouth disease | |
| CN103656306A (en) | Traditional Chinese medicine for treating urinary tract infection | |
| CN105920208A (en) | Medicinal composition for treating infantile wind-heat type common cold | |
| CN104189610A (en) | Traditional Chinese medicine composition for treating bronchitis | |
| CN114522202A (en) | Application of Huoxiangzhengqi liquid in preparing external application fever reducing medicine for treating cold and fever of children and preparation method | |
| CN104906503A (en) | Traditional Chinese medicine composition for treating alcoholic liver | |
| CN103610984B (en) | A kind of oral liquid and preparation method for the treatment of septicemia | |
| CN104435133A (en) | Medicament for reducing fever |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |