CN104524113A - Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease lung-spleen damp-heat syndrome and nursing method - Google Patents
Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease lung-spleen damp-heat syndrome and nursing method Download PDFInfo
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- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating a hand-foot-and-mouth disease lung-spleen damp-heat syndrome. The hand-foot-and-mouth disease lung-spleen damp-heat syndrome belongs to the warm disease category of traditional Chinese medicine, and analyzed from the pathogenetic process and the pathogenetic characteristic of the syndrome, the syndrome is generated due to damp-heat interior retention, external infection seasonal pathogen, internal and external fumigation and fleshy exterior hepatic depression. By the adoption of the traditional Chinese medicine preparation, decoction is obtained by selecting and decocting traditional Chinese medicine of lysimachia christinae, tussilago farfara, oroxylum indicum, trichosanthes kirilowii, viola japonica, lysimachia phyllocephala hand, common adenostema herbs, dioscorea hemsleyi, lens culinaris and amaranthus viridis with water. Clinical tests show that improvement of indexes of a test group is better than that of a control group, and the curative effect is obvious.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease lung dampness-heat in the spleen disease.
Background technology
Hand-foot-mouth disease had fashion trend in China in recent years, became the commonly encountered diseases in infant period, frequently-occurring disease, and this disease is multiple is born in preschool, is especially multiplely born in less than 3 years old child.Principal causative virus is enterovirus, common with section Sa Qi A group 16 type (CoxA16), enterovirns type 71 (EV71), the current doctor trained in Western medicine of primary disease there is no specific treatment medicine, mainly takes the measures such as anti symptom treatment, its curative effect affirmative, but side effect is many.
China's Chinese herbal medicine resource enriches, Chinese medicine with a long history, and prescription medicine is particular about, and compatibility is superior, and the composite parts too many levels of Chinese medicine, multiple target effect, in body, have unique curative effect to the treatment of various diseases.Chinese medicine and pharmacy, in the warm disease for the treatment of, is prevented and treated the popular aspect of epidemic febrile disease and is had huge advantage, can make up the deficiency of simple western medicine treatment.Herbal enema method also gradually pay attention to by more doctor, because patient was based on the children's of less than 5 years old, to be orally not easily accepted, clysmata effectively, quick, be convenient to infant and accept.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease lung dampness-heat in the spleen disease.Primary disease surely belongs to the traditional Chinese medical science " epidemic febrile disease " category, and from its pathogenic process and Analysis on Clinical Characteristics of Elder Patients, primary disease is by retention of damp-heat in the interior, diseases caused by exogenous pathogenic factor seasonal pathogen, and inside and outside stifling, pent-up flesh table forms.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment hand-foot-mouth disease lung dampness-heat in the spleen disease is made up of the Chinese medicine of following weight portion: Herba Parnassiae Wightianae 5-10 part, Flos Farfarae 1-3 part, Semen Oroxyli 1-2 part, Fructus Trichosanthis 4-8 part, Herba Violae mundae 3-5 part, Radix Lysimachiae Phyllocephalae 6-12 part, Herba Adenostemmatis 10-20 part, Radix dioscoreae subcalvae 10-20 part, Radix Crotalariae szemoensis 10-15 part, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 8-10 part.
Preferably, Herba Parnassiae Wightianae 7 parts, Flos Farfarae 2 parts, Semen Oroxyli 1.5 parts, Fructus Trichosanthis 6 parts, Herba Violae mundae 4 parts, Radix Lysimachiae Phyllocephalae 8 parts, Herba Adenostemmatis 15 parts, Radix dioscoreae subcalvae 15 parts, Radix Crotalariae szemoensis 12 parts, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 9 parts.
Preparation method decocting makes decoction.
Fang Zhong: Herba Parnassiae Wightianae tonifying the lung and stopping cough; Flos Farfarae nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing; Semen Oroxyli lung moistening, soothing the liver, stomach function regulating, granulation promoting; Fructus Trichosanthis moistening the lung and resolving phlegm, eliminating stagnation intestine moistening; Herba Violae mundae clearing away heat to dispel wind, subside a swelling soothing the liver; Radix Lysimachiae Phyllocephalae expelling wind and clearing away heat, to reduce phlegm; Herba Adenostemmatis induces sweat, dispel the wind, removing dampness; Radix dioscoreae subcalvae invigorating the spleen to clear away damp pathogen, tonifying the lung kidney; Radix Crotalariae szemoensis eliminating inflammation and expelling toxin, sharp larynx pain relieving; Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) heat-clearing and toxic substances removing, inducing diuresis and reducing edema.
Clinical data
1, physical data originally studies 60 routine infants all from my institute's pediatric ward in year March in March, 2011 to 2012, is divided into test group 30 example at random, matched group 30 example.All cases all meets Western medicine diagnose standard and Standards of Chinese Medical Syndrome Differentiation.Two groups of sexes, age, the course of disease, cardinal symptom, signs occur that frequency distribution is through X
2inspection P > 0.05, there was no significant difference, has comparability.
2, " hand-foot-mouth disease practice guidelines " Western medicine diagnose standard of issuing according to 2010 Nian Ban Ministry of Public Health general offices of diagnostic criteria: (1), in epidemic season (Xia Qiu) morbidity, be common in preschooler, infant is common; (2) heating companion hands, foot, mouth, buttocks erythra, some cases can without heating paresthesia; (3) only a few severe cases erythra is not true to type, clinical diagnosis difficulty, needs Binding experiment room to detect and makes diagnosis; (4) if without erythra, clinically hand-foot-mouth disease should not be diagnosed as.
Lung dampness-heat in the spleen disease tcm diagnosis standard primary symptom: heating, there is maculopapule, herpes in hands, foot, mouth and crissum, distributes sparse, and bleb liquid is limpid, and oral mucosa occurs being dispersed in herpes, with red, the sialorrhea of pharynx, look asthenia.Secondary disease: 1. cough, swallow pain; 2. Nausea and vomiting, have loose bowels or constipation; 3. red tongue, yellow, greasy and thin fur, floating and rapid pulse.Possess primary symptom, add time disease two (tongue fur, pulse condition are indispensable) namely diagnosable simultaneously.
3, Therapeutic Method test group applies Chinese medicine preparation of the present invention, take Herba Parnassiae Wightianae 7g, Flos Farfarae 2g, Semen Oroxyli 1.5g, Fructus Trichosanthis 6g, Herba Violae mundae 4g, Radix Lysimachiae Phyllocephalae 8g, Herba Adenostemmatis 15g, Radix dioscoreae subcalvae 15g, Radix Crotalariae szemoensis 12g, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 9g, decocting makes decoction, infant gives coloclysis administration, 2 times/day, during coloclysis, connect syringe with silica gel tube, anal 2 ~ 4cm place is inserted in its one end, medicinal liquid is slowly injected, tube drawing after clamp 30 minutes.
Matched group: (Shandong Huaxin Pharmaceutical Co., Ltd. produces ribavirin (ribavirin), the accurate word H 19993278 of traditional Chinese medicines, specification: often prop up 1ml:0.1g, lot number 050617), dosage is 10mg/kg every day, add in 10%GS100 ~ 200ml, intravenous drip, 1 times/day.
4, criterion of therapeutical effect hand-foot-mouth disease clinical efficacy canonical reference State Administration of Traditional Chinese Medicine issues " disease of tcm Standardization of diagnosis and curative effect " is formulated.(1) effective: in 48 hours, temperature recovery is normal, general state takes a turn for the better, and stomatocace heals completely, can take food, normally play.(2) effective: in 72 hours, temperature recovery is normal, general state takes a turn for the better, and stomatocace alleviates but do not heal completely, can take food, and spirit is poor.(3) invalid: treat and still generate heat for 4 days, feed is obstructed, oral mucosa is congested, fester obviously, merges bacteriological infection.
5, therapeutic outcome
(1) two group of total effects compares in table 1.
Table 1 test group compares (example) with matched group total effects
Note: two groups of total effective rates have significant difference than real, illustrate that test group curative effect is better than matched group.
(2) test group compares in table 2 in the 4th, 8 days with matched group cardinal symptom, table 3
Table 2 test group and matched group cardinal symptom the 4th day improvement situation compares (example)
Note: through X 2 test, mark
*person shows that two groups of cardinal symptom signs compare before the treatment afterwards, and P < 0.05, has significant difference; All the other cardinal symptom signs compare before the treatment afterwards, P > 0.05, there was no significant difference.
Table 3 test group and matched group cardinal symptom the 8th day improvement situation compares (example)
Note: through X 2 test, mark
* person shows that two groups of cardinal symptom signs compare before the treatment afterwards, and P < 0.05, has significant difference; All the other cardinal symptom signs compare before the treatment afterwards, P > 0.05, there was no significant difference.
Two groups of laboratory parameters are normal before all there is not treatment, abnormal conditions after treatment; Two groups of laboratory parameters there are no significant difference, illustrates that test group and matched group have good safety.
Detailed description of the invention
Embodiment one: take Herba Parnassiae Wightianae 7g, Flos Farfarae 2g, Semen Oroxyli 1.5g, Fructus Trichosanthis 6g, Herba Violae mundae 4g, Radix Lysimachiae Phyllocephalae 8g, Herba Adenostemmatis 15g, Radix dioscoreae subcalvae 15g, Radix Crotalariae szemoensis 12g, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 9g, decocting makes decoction.
Embodiment two: take Herba Parnassiae Wightianae 10g, Flos Farfarae 1g, Semen Oroxyli 2g, Fructus Trichosanthis 4g, Herba Violae mundae 5g, Radix Lysimachiae Phyllocephalae 6g, Herba Adenostemmatis 20g, Radix dioscoreae subcalvae 10g, Radix Crotalariae szemoensis 15g, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 8g, decocting makes decoction.
Embodiment three: take Herba Parnassiae Wightianae 5g, Flos Farfarae 3g, Semen Oroxyli 1g, Fructus Trichosanthis 8g, Herba Violae mundae 3g, Radix Lysimachiae Phyllocephalae 12g, Herba Adenostemmatis 10g, Radix dioscoreae subcalvae 20g, Radix Crotalariae szemoensis 10g, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 10g, decocting makes decoction.
Claims (2)
1. treat a Chinese medicine preparation for hand-foot-mouth disease lung dampness-heat in the spleen disease, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Herba Parnassiae Wightianae 5-10 part, Flos Farfarae 1-3 part, Semen Oroxyli 1-2 part, Fructus Trichosanthis 4-8 part, Herba Violae mundae 3-5 part, Radix Lysimachiae Phyllocephalae 6-12 part, Herba Adenostemmatis 10-20 part, Radix dioscoreae subcalvae 10-20 part, Radix Crotalariae szemoensis 10-15 part, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 8-10 part.
2. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease lung dampness-heat in the spleen disease according to claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Herba Parnassiae Wightianae 7 parts, Flos Farfarae 2 parts, Semen Oroxyli 1.5 parts, Fructus Trichosanthis 6 parts, Herba Violae mundae 4 parts, Radix Lysimachiae Phyllocephalae 8 parts, Herba Adenostemmatis 15 parts, Radix dioscoreae subcalvae 15 parts, Radix Crotalariae szemoensis 12 parts, Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi) 9 parts.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641048A (en) * | 2016-01-22 | 2016-06-08 | 宋亚 | Traditional Chinese medicine for treating children hand-foot-mouth disease and preparation method thereof |
| CN105902887A (en) * | 2016-06-05 | 2016-08-31 | 葛文农 | Traditional Chinese medicine pills for effectively treating hand-foot-and-mouth disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330808A (en) * | 2013-07-05 | 2013-10-02 | 郭京娟 | Traditional Chinese medicine preparation for treating pediatric hand-foot-and-mouth disease |
| CN103340986A (en) * | 2013-07-05 | 2013-10-09 | 张霞 | Traditional Chinese medicine enema for treating hand-foot-and-mouth disease of children |
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2015
- 2015-01-04 CN CN201510009006.XA patent/CN104524113A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330808A (en) * | 2013-07-05 | 2013-10-02 | 郭京娟 | Traditional Chinese medicine preparation for treating pediatric hand-foot-and-mouth disease |
| CN103340986A (en) * | 2013-07-05 | 2013-10-09 | 张霞 | Traditional Chinese medicine enema for treating hand-foot-and-mouth disease of children |
Non-Patent Citations (2)
| Title |
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| 岳伟等: "中医辨证论治小儿手足口病", 《吉林中医药》 * |
| 杨立: "《生命的礼物（中）》", 28 February 2014, 九州出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641048A (en) * | 2016-01-22 | 2016-06-08 | 宋亚 | Traditional Chinese medicine for treating children hand-foot-mouth disease and preparation method thereof |
| CN105902887A (en) * | 2016-06-05 | 2016-08-31 | 葛文农 | Traditional Chinese medicine pills for effectively treating hand-foot-and-mouth disease |
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