CN103340986A

CN103340986A - Traditional Chinese medicine enema for treating hand-foot-and-mouth disease of children

Info

Publication number: CN103340986A
Application number: CN2013102944605A
Authority: CN
Inventors: 张霞
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-07-05
Filing date: 2013-07-05
Publication date: 2013-10-09
Anticipated expiration: 2033-07-05
Also published as: CN103340986B

Abstract

The invention discloses a traditional Chinese medicine enema for treating hand-foot-and-mouth disease of children. The hand-foot-and-mouth disease belongs to category of epidemic and warm disease in traditional Chinese medicine and is caused by leaking internal damp toxin of lung and spleen and pent-up on the skin of external wind-warm syndrome. The traditional Chinese medicine enema disclosed by the invention is prepared to enema by selecting radix tinosporae, radix tinosporae, Chinese trumpet creeper, lithospermum, Sedum sarmentosum, Chinese olive, Amomum tsao-ko, deutzia ningpoensis rehd, burdock, souliea vaginata and liquorice. Through clinical test, the total effective rate is 97.5%. Time on abatement of fever, healing time of dental ulcer and eliminating time of herpes are shorter than those of control group.

Description

A kind of herbal enema agent for the treatment of Hand-Food-Mouth Disease

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of herbal enema agent for the treatment of Hand-Food-Mouth Disease.

Background technology

Hand-foot-mouth disease is one of more common infectious disease of department of pediatrics, cardinal symptom shows as maculopapule, the herpes at positions such as hands, foot, oral cavity, meningitis, encephalitis, encephalomyelitis, pulmonary edema, circulatory disturbance etc. can appear in the minority case, and the cause of death is mainly brain stem encephalitis and neurogenic pulmonary edema.Sickness rate is in rising trend in recent years, and the sickness rate of child below three years old is the highest, and older youngster and adult also can be infected.The route of infection are mainly respiratory tract, digestive tract and contact closely.The Chinese medicine hand-foot-mouth disease has certain advantage.But the medication in children difficulty, herbal drug enema in treatment makes medicine directly absorb through intestinal mucosa, can directly act on diseased region for a long time, thereby effectively bring into play local application's effect, has to absorb fully, and the advantage that bioavailability is high improves cure rate.

Summary of the invention

The purpose of this invention is to provide a kind of herbal enema agent for the treatment of Hand-Food-Mouth Disease.Hand-foot-mouth disease belongs to " epidemic disease " and categories such as " epidemic febrile diseases " in motherland's medical science, be to leak due to the evil pent-up flesh table with the diseases caused by exogenous pathogenic factor pathogenic wind-warm by accumulateing noxious dampness in the lung spleen channel.Children's's lungs are tender and lovely, and not anti-heresy is disturbed, the spleen tending to insufficiency usually, subject to damage.The heresy of pathogenic wind-warm is gone into by mouth and nose, in invade the lung spleen.The lung genus closes fur outside defending, and main Xuan Fasu falls, and is source on the water; Spleen pertaining to the earth, department's fortuneization, main limb muscle is reservoir of food and drink, has one's ideas straightened out in mouth.Evil poison first offender, Lung Qi obstraction, defensive QI being obstructed, temper is lost strong, and stomach-QI being unable to descend normally is then seen diseases such as heating, cough, watery nasal discharge, stomatalgia, poor appetite; Evil poison accumulates strongly fragrant, disturbance in functioning of QI, and retention of water-damp in the body is fought mutually with poison, and the flesh table of passing through inside is then sent out herpes.

Purpose of the present invention is achieved through the following technical solutions, and the herbal enema agent of this treatment Hand-Food-Mouth Disease is made by following parts by weight of Chinese traditional medicine: Radix Tinosporae 7-15 part, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 5-10 part, Flos Campsis 8-13 part, Radix Arnebiae (Radix Lithospermi) 9-12 part, Herba Sedi 15-20 part, Fructus Canarii 4-16 part, Herba Violae mundae 6-9 part, Folium seu Radix Deutziae ningoensis 9-15 part, Fructus Arctii 10-18 part, Rhizoma soulieae vaginatae 5-9 part, Radix Glycyrrhizae 3-4 part.

Preferably, 13 parts of Radix Tinosporaes, 8 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s, 12 parts of Flos Campsiss, 11 parts of Radix Arnebiae (Radix Lithospermi)s, 17 parts of Herba Sedis, Fructus Canarii, 10 parts, 7 parts of Herba Violae mundaes, 12 parts of Folium seu Radix Deutziae ningoensis, 15 parts of Fructus Arctiis, 7 parts of Rhizoma soulieae vaginataes, 3.5 parts in Radix Glycyrrhizae.

Preparation method is with above-mentioned Chinese medicine decocting, extracting juice coloclysis.

In the side: Radix Tinosporae, Radix Apioris Fortunei (Radix Lespedezae Buergeri) heat-clearing and toxic substances removing, relieving sore throat and pain, dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain; Radix Arnebiae (Radix Lithospermi), Flos Campsis, Rhizoma soulieae vaginatae cooling blood, expelling wind, detoxifcation rash, antiulcer, pathogenic fire purging dampness, the relieving restlessness that clears away heart-fire, anti-inflammation; Herba Sedi, Fructus Canarii clearing away heat-damp and promoting diuresis, sore-throat relieving, the detoxifcation of promoting the production of body fluid; Urinate in Herba Violae mundae, Ningbo, the Fructus Arctii wind and heat dispersing, the diuresis of bringing down a fever, rash sore-throat relieving, removing toxic substances and promoting subsidence of swelling; The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough is alleviated pain relieving.

Clinical data

1, the selected infant of physical data derives from serious symptom hand-foot-mouth disease infant 240 examples that my institute accepts for medical treatment year January in January, 2009 to 2011, all meet the serious symptom hand-foot-mouth disease diagnostic criteria in " hand-foot-mouth disease practice guidelines (2010 editions) " that China Ministry of Public Health formulates, be divided into two groups at random.120 examples are organized in treatment, male 72 examples wherein, women 48 examples, 5 months to 5 years old age, average (1.9 ± 1.1) year; The course of disease 1～3d, average (2.5 ± 1.3) d; Matched group 120 examples, male 76 examples wherein, women 44 examples, 6 months to 6 years old age, average (2.1 ± 12) year, the course of disease 2～4d, average (2.3 ± 1.4) d; Two groups of infants are the difference not statistically significant on severity extents such as heating, vomiting, easily frightened, limbs shake, erythra.

2, diagnostic criteria all meets " hand-foot-mouth disease practice guidelines (version in 2008) " middle hand-foot-mouth disease plain edition and the heavy diagnostic criteria that Ministry of Health of the People's Republic of China issues.

3, Therapeutic Method treatment group infant uses herbal enema agent of the present invention, every day potion.Enema method: the temperature of enema is 38～40 ℃, and coloclysis can be conducive to the absorption of enema and the reservation in enteric cavity under this temperature, connects venous transfusion needle tubing (the syringe needle obtuse cuts off) retention enema with the 20mL syringe, and the degree of depth is about 8～10cm, every day 2 times.Each 20mL, 10d continuously.Matched group gives ribavirin 10～15mg/ (kg/d) and adds 5% glucose 50mL intravenous drip, every day 1 time; Two groups equal 10 days be a course for the treatment of.

4, criterion of therapeutical effect produce effects: temperature recovery is normal in the treatment 3d, the dry no sepage of incrustation of herpes and obvious the minimizing, and the infant ordinary circumstance takes a turn for the better, and feed returns to normal, and is in high spirits; Effectively: temperature recovery is normal in the treatment 4d, the most of dry incrustation of herpes, and ordinary circumstance takes a turn for the better, and feed increases; Invalid: still heating behind the treatment 5d, the more preceding no minimizing of herpes or increase or ulceration merge bacterial infection, few food.

5, (1) two group for the treatment of back of therapeutic outcome curative effect relatively sees Table 1.

Table 1 liang group treatment back curative effect relatively

Compare P＜0.05 with matched group.

Two groups of relatively treatment group obvious effective rates, total effective rate obviously are better than matched group, have comparability.P＜0.05。

(2) two groups for the treatment of back clinical symptom disappearance time ratios see Table 2.

Table 2 liang group treatment back clinical symptom disappearance time ratio

Compare P＜0.05 with matched group.

Two groups of clinical symptom disappearance time ratios are brought down a fever after the treatment group treatment, oral ulcer healing, erythra extinction time all be significantly shorter than matched group, has comparability.P＜0.05。

The specific embodiment

Embodiment one: take by weighing Radix Tinosporae 13g, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 8g, Flos Campsis 12g, Radix Arnebiae (Radix Lithospermi) 11g, Herba Sedi 17g, Fructus Canarii 10g, Herba Violae mundae 7g, Folium seu Radix Deutziae ningoensis 12g, Fructus Arctii 15g, Rhizoma soulieae vaginatae 7g, Radix Glycyrrhizae 3.5g, with above-mentioned Chinese medicine decocting, extracting juice coloclysis.

Embodiment two: take by weighing Radix Tinosporae 15g, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 5g, Flos Campsis 13g, Radix Arnebiae (Radix Lithospermi) 9g, Herba Sedi 20g, Fructus Canarii 4g, Herba Violae mundae 9g, Folium seu Radix Deutziae ningoensis 15g, Fructus Arctii 10g, Rhizoma soulieae vaginatae 5g, Radix Glycyrrhizae 3g, with above-mentioned Chinese medicine decocting, extracting juice coloclysis.

Embodiment three: take by weighing Radix Tinosporae 7g, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 10g, Flos Campsis 8g, Radix Arnebiae (Radix Lithospermi) 12g, Herba Sedi 15g, Fructus Canarii 16g, Herba Violae mundae 6g, Folium seu Radix Deutziae ningoensis 9g, Fructus Arctii 18g, Rhizoma soulieae vaginatae 9g, Radix Glycyrrhizae 4g, with above-mentioned Chinese medicine decocting, extracting juice coloclysis.

Claims

1. herbal enema agent for the treatment of Hand-Food-Mouth Disease is characterized in that this herbal enema agent made by following parts by weight of Chinese traditional medicine: Radix Tinosporae 7-15 part, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 5-10 part, Flos Campsis 8-13 part, Radix Arnebiae (Radix Lithospermi) 9-12 part, Herba Sedi 15-20 part, Fructus Canarii 4-16 part, Herba Violae mundae 6-9 part, Folium seu Radix Deutziae ningoensis 9-15 part, Fructus Arctii 10-18 part, Rhizoma soulieae vaginatae 5-9 part, Radix Glycyrrhizae 3-4 part.

2. a kind of herbal enema agent for the treatment of Hand-Food-Mouth Disease according to claim 1 is characterized in that this herbal enema agent made by following parts by weight of Chinese traditional medicine: 13 parts of Radix Tinosporaes, 8 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s, 12 parts of Flos Campsiss, 11 parts of Radix Arnebiae (Radix Lithospermi)s, 17 parts of Herba Sedis, Fructus Canarii, 10 parts, 7 parts of Herba Violae mundaes, 12 parts of Folium seu Radix Deutziae ningoensis, 15 parts of Fructus Arctiis, 7 parts of Rhizoma soulieae vaginataes, 3.5 parts in Radix Glycyrrhizae.