CN103948829A - Traditional Chinese medicinal formula for treating infantile pneumonia - Google Patents

Abstract

The invention provides a traditional Chinese medicinal formula for treating infantile pneumonia. The traditional Chinese medicinal formula comprises the following raw medicinal materials in parts by weight: 5-15 parts of momordica grosvenori, 15-50 parts of houttuynia cordata, 5-15 parts of lalang grass rhizome, 5-15 parts of perilla stem, 5-15 parts of white mulberry root-bark, 15-50 parts of lily, 5-15 parts of wild chrysanthemum flower, 5-15 parts of isatis root and 5-15 parts of grass. The traditional Chinese medicinal decoction has a good effect for treating infantile pneumonia by combining with conventional western medical treatment, does not have toxic or side effect, can play the characteristic of quick response of western medicines and the advantages of durable action of traditional Chinese medicinal decoction and strong persistency of dialectical administration when being used for treating infantile pneumonia, is short in course of treatment, small in dosage and early in rehabilitation, and can be used for effectively preventing one more affection of infantile pneumonia.

Description

The Chinese prescription for the treatment of infantile pneumonia

Technical field

The present invention relates to a kind of Chinese prescription for the treatment of infantile pneumonia.

Background technology

Infantile pneumonia is by the pulmonary disease due to different pathogens or other factors, taking the fixing moist rales of heating, cough, tachypnea, dyspnea and pulmonary as its common clinical, the modal pediatric disease of developing country, the first cause of Ye Shi developing country death of child.No matter be that sickness rate or mortality rate all rank first, its encountered pathogenic is antibacterial, virus, also can be by antibacterial, virus mixed infection.Taking the hyperemia of lung tissue, edema, inflammatory infiltration as main.Primary disease belongs to the category that traditional Chinese medical science pneumonia asthma is coughed, be due to the gas of experiencing six climate exopathogens, invade lung meridian, or eating and drinking without temperance, lung spleen deficiency in origin, the raw wet expectorant of making, stops up stagnant lung network, and chance leaks and triggers, cause heresy to close lung network, impairment of purifying function of the lung, seriously can cause qi depression to blood stasis, wind heat to close lung or phlegm-heat closed lung etc., and often follow asthenia of pulmonosplenic qi, the infantile pneumonia deficiency syndrome such as deficiency of YIN lung-heat.For many years, in the selection of infantile pneumonia Therapeutic Method, most employing doctor trained in Western medicine antiinflammatories, cough-relieving, the treatment of relievining asthma, although this Therapeutic Method curative effect certainly, also can meet the treatment of infantile pneumonia, but be widely used due to antibiotic, make drug resistance and gram-negative bacteria and the viral infection increase of antibacterial, the treatment difficulty day by day that makes pneumonia all obviously rises than before in time and expense.Both the had immediate effect effect of relief of symptoms of Chinese Medicine and Clavicular western medicine infantile pneumonia, the effect that has again the pneumonia of preventing again to show effect.

Summary of the invention

The object of this invention is to provide a kind of Chinese prescription for the treatment of infantile pneumonia, its combined with westem conventional therapy is good to infantile pneumonia therapeutic effect, and has no side effect.Treatment infantile pneumonia can be brought into play the rapid-action feature of Western medicine, can bring into play again Chinese medicine decoction effect lasting, has dialectical medication advantage with strong points, and short treating period, medication are few, recover early, can effectively prevent from again suffering from infantile pneumonia.

Treat a Chinese prescription for infantile pneumonia, the crude drug of this Chinese prescription and weight proportion thereof are:

5 ~ 15 parts of 15 ~ 50 parts of Rhizoma Imperataes of 5 ~ 15 parts of Herba Houttuyniae of Fructus Momordicae

15 ~ 50 parts of 5 ~ 15 portions of Bulbus Liliies of 5 ~ 15 parts of Cortex Mori of Caulis Perillae

5 ~ 15 parts, 5 ~ 15 portions of Radix Glycyrrhizaes of 5 ~ 15 parts of Radix Isatidis of Flos Chrysanthemi Indici

Further, the crude drug of this Chinese prescription and weight proportion thereof are preferably:

15 parts of 50 parts of Rhizoma Imperataes of 15 parts of Herba Houttuyniae of Fructus Momordicae

50 parts of 15 portions of Bulbus Liliies of 15 parts of Cortex Mori of Caulis Perillae

15 parts, 15 portions of Radix Glycyrrhizaes of 15 parts of Radix Isatidis of Flos Chrysanthemi Indici

In Chinese prescription of the present invention, Fructus Momordicae has the title of good medicine god fruit, and sweet in the mouth is cool in nature, has clearing heat and moistening lung, cough-relieving sore-throat relieving, and clearing away lung-heat is except restlessness and coughing, and effect of inducing diuresis to remove edema, is " good medicine ".Herba Houttuyniae, Rhizoma Imperatae, Cortex Mori, Flos Chrysanthemi Indici, Radix Isatidis all have heat-clearing and toxic substances removing, inducing diuresis to remove edema, relieving cough and asthma, anti-inflammatory antipyretic, pyretic toxicity from clear effect, are " ministerial drug ".The Caulis Perillae taste warp of returning warm in nature, can regulating the flow of QI to ease the stomach, and the gastral cavity abdomen feeling of fullness that disappears evilly goes out from down, and abdominal distention dyspnea with rapid respiration must be pacified, and diet can enter, and resistance strengthens, and can play the effect of " righting of getting rid of evils ".Bulbus Lilii has nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, and the trouble of eliminating dysphoria and expectorant numbness, is rested infant, lung being a delicate viscus, infant body constitution is refined tender, more can not impairment of YIN, protect lung with Bulbus Lilii nourishing YIN, be " adjuvant drug ".Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, emergency is alleviated pain, and trachea is able to unimpeded, and makes all medicines respectively return its warp, can reach satisfied therapeutic efficiency, for " adjuvant drug ", above-mentioned nine taste Chinese herbal medicine, through dialectical prescription, organic compatibility, are assisted a ruler in governing a country mutually, can reach heat-clearing and toxic substances removing, relieving cough and resolving phlegm, relieving asthma, the effect of inducing diuresis to remove edema, the righting of getting rid of evils, thereby realize short treating period, medication few, recover early, object that long-term efficacy is good.

Chinese medicine decoction combined with westem conventional therapy of the present invention is good to infantile pneumonia therapeutic effect, and has no side effect.Treatment infantile pneumonia can be brought into play the rapid-action feature of Western medicine, can bring into play again Chinese medicine decoction effect lasting, has dialectical medication advantage with strong points, and short treating period, medication are few, recover early, can effectively prevent from again suffering from infantile pneumonia.

 

acute toxicity test of the present invention is as follows:

One, experiment material

Animal: Kunming kind white mice is provided by laboratory animal room of Lanzhou Institute of Biological Products, body weight is (20 ± 2) g.

Medicine: the Chinese prescription of the embodiment of the present invention 1 is decocted after half an hour concentrated for subsequent use with distilled water slow fire slowly.

Two, experimental technique: mtd test

30 of female mices, experiment the previous day, water is can't help in fasting overnight, under the condition of 20 ± 2 DEG C of room temperatures, gastric infusion three times in 24 hours, dosage is 15.0g/Kg, gives observation post administration two weeks.

Result mice is after administration in 30 minutes, and because administration volume is bigger than normal, slightly uncomfortable, it shows as mice and has loose bowels, back of a bow phenomenon, recovers rapidly normal subsequently, and quieter, Continuous Observation two weeks, mice all survives, and cuts open inspection, and naked eyes examine main inner internal organs, no abnormality seen.

Three, experiment conclusion: according to the requirement of Chinese medicine toxicological study, can accept the maximum volume under Cmax mice, carry out mtd test.Mice is all survivals within the observation period, have no overt toxicity, show that this poison of drug is very little, clinical use safety.

clinical research data of the present invention is as follows:

1. physical data

Selected 508 routine cases are and become clinic to be diagnosed as the patient of infantile pneumonia at Wang Ke year January in January, 2003 to 2009, the age between 1 years old one 14 years old, average 5.28 years old; Wherein male 282 examples, female's 226 examples; Course of disease 1-29 days.Most of infants were once repeatedly suffered from infantile pneumonia, and once repeatedly with Chinese and western drugs treatment, though the state of an illness is clearly better, repeatedly suffered from infantile pneumonia.

2. diagnostic criteria

(1) onset is more anxious, the lighter's fever and cough, abundant expectoration between larynx, severe one rapid breathing, flaring of nares, there is dysphoria in severe patient, pale complexion, steel gray or cyanosis of the lips and nails, extremity not warm or faint cold, in a short time liver increase; Or lasting high fever is endlessly, unconsciousness and delirium, tic of the limbs.The above-mentioned partial symptoms of young infant of neonatal, plain bromhidrosis YANG deficiency can not be true to type.

(2) auscultation of lung audible and middle fine crackles.

(3) chest X-ray enhanced lung markings, disorder, visible strip, patch shape shade, or see inhomogeneous large lamellar shade.

(4) can get rid of other hearts, lung disease (as pulmonary tuberculosis, asthma, bronchiectasis, pulmonary carcinoma, heart disease etc.) person.

3. observation index

The one, observe infant spirit, diet, body temperature, pant tachypnea emergency, cough degree and frequency, expectoration quantity, expectorant color change, and auscultation pulmonary rale changes; The 2nd, observe infant chest x-ray and change.

4. Therapeutic Method

Above 508 routine patients are divided into two groups at random, treatment group 260 examples, male 144 examples, female's 116 examples, 1 ~ 14 years old age, average 3.27 years old, the course of disease 1 ~ 26 day, average 4.17 days; Matched group 248 examples, male 138 examples, female's 110 examples, 1 ~ 14 years old age, average 3.25 years old, the course of disease 1 ~ 29 day, average 4.25 days; .Two groups of patients all give routine of western medicine treatment: by infection, cough-relieving, reduce phlegm, relieving asthma, the conventional therapies such as oxygen supply, heart tonifying, diuresis if desired; Treatment group adds uses above-mentioned treatment by Chinese herbs.1 ~ 3 year old, 1/3 dose of every day; 4 ~ 6 years old, 1/2 dose of every day; 7 ~ 9 years old, 2/3 dose of every day; 10 ~ 14 years old, 1 dose of every day.

Every dose of medicine warm water 200-500ml soaks 30-60 minutes, and 30 minutes at a simmer, decoct three times, extracting juice 100 ~ 250ml left and right, takes several times altogether.Serve on 3-5 days.

5. clinical efficacy judgement

5.1 curative effect judgements:

The efficacy assessment standard of " disease of tcm Standardization of diagnosis and curative effect TCM Pediatrics Illnesses Diagnoses criterion of therapeutical effect " the interior pneumonia cough of issuing for 1994 with reference to State Administration of Traditional Chinese Medicine.

(1) cure: symptom, sign disappear substantially, and primary symptom integration is 0;

(2) effective: symptom, sign disappear mostly, primary symptom integration reduces >=2/3;

(3) take a turn for the better: symptom, sign alleviate, primary symptom integration reduces >=1/3, but < 2/3;

(4) invalid: symptom, sign is without significant change or increase the weight of, primary symptom integration reduces.

5.2 therapeutic outcomes:

In order to upper Regimen Chemotherapy 3-5 days, treatment 508 routine infantile pneumonia patients, therapeutic effect is as follows:

(1) two group of curative effect comparison

Total obvious effective rate for the treatment of group and matched group is respectively 99.23% and 91.94%, learns and processes by statistics, and difference has statistical significance (P < 0.05).In table 1.

Clinical efficacy comparison [example] after table 1 liang group treatment

Group	Number of cases	Cure	Effective	Take a turn for the better	Invalid	Total obvious effective rate
							Matched group	248	174	30	24	20	228（91.94%）
Treatment group	260	236	14	8	2	258（99.23%）

(2) two groups of symptoms, the comparison of sign extinction time

Treatment group clinical symptoms, sign extinction time and matched group comparison, learn and process by statistics, and difference has statistical significance (P<0.05).In table 2.

The comparison of table 2 liang group symptom, sign extinction time [my god (± S]

Group	Number of cases	Fever time	Cough extinction time	Rale extinction time
					Matched group	248	3.93±1.17	6.78±2.44	6.46±2.14
Treatment group	260	2.12±1.05	4.48±2.12	4.52±2.02

(3) after treatment, follow up a case by regular visits to the comparison that again occurs pulmonary infection in 6 months

After treatment, follow up a case by regular visits to and in 6 months, again occur pulmonary infection comparison (matched group has 22 examples, treatment group to have 26 examples cannot follow up a case by regular visits to because of a variety of causes): the total reinfection rate for the treatment of group and matched group is respectively 8.55% and 40.71%, learn and process by statistics, have significant difference (P < 0.001).In table 3.

Again there is the comparison [example] of pulmonary infection in table 3 liang group

Group	Number of cases	Without infecting again	Once infect again	Repeatedly infect again	Total reinfection rate
						Matched group	226	134	76	16	92（40.71%）
Treatment group	234	214	18	2	20（8.55%）

Clinical research result shows: few in conjunction with conventional western medicine infantile pneumonia short treating period, medication with this Chinese prescription, recover early, long-term efficacy is good, and have no side effect.

Detailed description of the invention

The following examples can further illustrate the present invention, but do not limit the present invention in any way.

Embodiment 1: crude drug and weight proportion thereof for the Chinese prescription of 10-14 years old children pneumonia are:

Fructus Momordicae 15g Herba Houttuyniae 50g Rhizoma Imperatae 15g

Caulis Perillae 15g Cortex Mori 15g Bulbus Lilii 50g

Flos Chrysanthemi Indici 15g Radix Isatidis 15g Radix Glycyrrhizae 15g

Decoction method for making: above 9 herbal medicines are added to 500 milliliters, warm water by above-mentioned weight, soak 30-60 minutes, slow fire is decocted 30 minutes slowly, decocts three times, gets altogether the about 250ml of supernatant, for subsequent use.

Instructions of taking:

When morbidity, on the basis of routine of western medicine treatment, add this prescription medicine, 10 ~ 14 years old infant, 1 dose of every day; Also can, to 1 ~ 3 years old infant, adopt 1/3 dose of every day; 4 ~ 6 years old infants, adopt 1/2 dose of every day; 7 ~ 9 years old infants, adopt 2/3 dose of every day; Clear water decoction, takes for three times, serve on five days for early, middle and late point.

The judgement of clinical efficacy of the present invention adopts the prescription of the present embodiment.

Embodiment 2: crude drug and weight proportion thereof for the Chinese prescription of 7-9 years old children pneumonia are:

Fructus Momordicae 10g Herba Houttuyniae 33g Rhizoma Imperatae 10g

Caulis Perillae 10g Cortex Mori 10g Bulbus Lilii 33g

Flos Chrysanthemi Indici 10g Radix Isatidis 10g Radix Glycyrrhizae 10g

Decoction method for making: above 9 herbal medicines are added to 400 milliliters, warm water by above-mentioned weight, soak 30-60 minutes, slow fire is decocted 30 minutes slowly, decocts three times, gets altogether the about 200ml of supernatant, for subsequent use.

Instructions of taking: when morbidity, add this prescription medicine, 1 dose of every day on the basis of routine of western medicine treatment; Clear water decoction, takes for three times, serve on five days for early, middle and late point.

Crude drug and the weight proportion thereof of the Chinese prescription of 3: 4-6 years old children pneumonia of embodiment are:

Fructus Momordicae 7g Herba Houttuyniae 25 g Rhizoma Imperatae 7 g

Caulis Perillae 7 g Cortex Mori 7 g Bulbus Lilii 25 g

Flos Chrysanthemi Indici 7g Radix Isatidis 7 g Radix Glycyrrhizae 7 g

Decoction method for making: above 9 herbal medicines are added to 300 milliliters, warm water by above-mentioned weight, soak 30-60 minutes, slow fire is decocted 30 minutes slowly, decocts three times, gets altogether the about 150ml of supernatant, for subsequent use.

Instructions of taking is with embodiment 2.

Crude drug and the weight proportion thereof of the Chinese prescription of 4: 1-3 years old children pneumonia of embodiment are:

Fructus Momordicae 5g Herba Houttuyniae 15 g Rhizoma Imperatae 5 g

Caulis Perillae 5 g Cortex Mori 5 g Bulbus Lilii 15g

Flos Chrysanthemi Indici 5g Radix Isatidis 5 g Radix Glycyrrhizae 5g

Decoction method for making: above 9 herbal medicines are added to 200 milliliters, warm water by above-mentioned weight, soak 30-60 minutes, slow fire is decocted 30 minutes slowly, decocts three times, gets altogether the about 100ml of supernatant, for subsequent use.

Instructions of taking is with embodiment 2.

Claims (2)

1. a Chinese prescription for the treatment of infantile pneumonia, is characterized in that: the crude drug of this Chinese prescription and weight proportion thereof are:

5 ~ 15 parts of 15 ~ 50 parts of Rhizoma Imperataes of 5 ~ 15 parts of Herba Houttuyniae of Fructus Momordicae

15 ~ 50 parts of 5 ~ 15 portions of Bulbus Liliies of 5 ~ 15 parts of Cortex Mori of Caulis Perillae

5 ~ 15 parts, 5 ~ 15 portions of Radix Glycyrrhizaes of 5 ~ 15 parts of Radix Isatidis of Flos Chrysanthemi Indici.

2. the Chinese medicine for the treatment of infantile pneumonia according to claim 1, is characterized in that: the crude drug of this Chinese prescription and weight proportion thereof are

15 parts of 50 parts of Rhizoma Imperataes of 15 parts of Herba Houttuyniae of Fructus Momordicae

50 parts of 15 portions of Bulbus Liliies of 15 parts of Cortex Mori of Caulis Perillae

15 parts, 15 portions of Radix Glycyrrhizaes of 15 parts of Radix Isatidis of Flos Chrysanthemi Indici.