CN103977226A - Traditional Chinese medicine compound preparation for treating pediatric cold and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating pediatric cold and a preparation method thereof. The compound preparation is prepared, through an extraction process, from following medicinal plants or decoction pieces including, in proportion by weight, 400-800g of honeysuckle flower, 400-800g of cordate houttuynia, 200-500g of blackberry lily rhizome, 200-500g of radix bupleuri, 100-300g of mint, 100-300g of anemarrhenae, 100-400g of radix scrophulariae and 100-400g of pogostemon. The compound preparation has effects of dispelling wind, releasing the exterior, clearing heat and detoxifying, is mainly used for exogenous wind-heat having symptoms of fever, aversion to wind, headache, bodily pain, hypodynamia, nasal obstruction, nasal discharge, sore throat, cough, dry mouth, red tongue, thin and yellow tongue fur and superficial and rapid pulse. The compound preparation is suitable for pediatric cold (upper respiratory tract infection).

Description

A kind of compound Chinese medicinal preparation for the treatment of infantile common cold and preparation method thereof

Technical field

The present invention relates to a kind of field of Chinese medicines, be specifically related to a kind of make taking the prepared slices of Chinese crude drugs as raw material be used for the treatment of compound Chinese medicinal preparation of infantile common cold and preparation method thereof.

Background technology

Acute upper respiratory tract infection is the common lung pattern disease of department of pediatrics, be called for short " upper sense ", the traditional Chinese medical science is referred to as " flu ", clinical taking symptoms such as aversion to cold, heating, nasal obstruction watery nasal discharge, sneeze, cough, pharyngalgia, pharynx discomforts as main; pathological changes is confined on throat; can be caused by multiple pathogens, and viral infection is the important pathogenic cause of disease of generally acknowledging.Because children's's lungs are tender and lovely, weakened defensive QI, the spleen tending to insufficiency usually, the kidney being always deficient, first the foundation of acquired constitution is easily damaged, and Gu Feiwei is subject to invade ill, therefore the sickness rate of flu is in first of lung pattern disease always, affects over the past thousands of years children's's health.Chinese medicine has the experience accumulation of more than 2000 year, has the advantage of individuation Coryza Treated by Syndrome Differentiation, meets the Development of Evidence-based Medicine trend of society, and social application is extensive.

In Pediatrics of Chinese Medicine, have children's's body to report " pure sun " and " the young sun of young the moon " two kinds of theories, men outnumbered women or YANG without YIN for the non-finger of its Pure yang theory children's, and refer to that children's's life is flourishing, blastoprolepsis, because of the main hair growth promoting of sun, therefore say pure sun; The young sun of young the moon is to refer to that children's's internal organs are tender and lovely, shape gas does not fill, and is all inmature incomplete from internal organs organ essence and blood body fluid to function.These two kinds of theories have all illustrated children's's body constitution physiological characteristics, the pathological characteristic that causes thus children's is that morbidity is easy, easily empty easily real, easily cold easily heat, so children's catches a cold, sickness rate is high, change of illness state has a great difference than adult soon, has unique pathological characteristic, easily merges folder expectorant and presss from both sides the frightened folder card of holding concurrently of stagnant folder.

Modern increasingly deep to the research of infantile common cold, the Study on etiology of modern medicine to upper respiratory tract infection, finds that protopathy is because approximately 90% be viral.This discussion to pathogen and pathology of tcm and dialectical rule has played facilitation aspect Chinese medicine experimental study, has set up cold, fever model.And the model of animal In vivo infection.The antiviral of vivo and vitro and antibacterial method are set up.This pharmacodynamics principle that makes Chinese medicine flu obtains the elaboration of science from improving many-side such as body's immunity, antiviral, antibacterial, antipyretic, antiinflammatory, also can screen and application provides theoretical foundation for cold medicine.

The Therapeutic Principle of flu should be to induce sweat as main, i.e. dispelling wind to relieve the exterior syndrome.The body of the young sun of children's, diaphoresis should not be too, in order to avoid consumption impairment of body fluid liquid.According to cold, heat, summer-heat, wet dialectical, there is relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, the dividing of dispelling summer-heat from superficies of the body.And should pay attention to the treatment that various double folders are demonstrate,proved.Ancient times typical case prescription: anemofrigid cold, relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, conventional " congchi tang " or " Antiphlogistic Powder of Schizonepetae and Ledebouriellae "; Anemopyretic cold, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, conventional " SANGJU YIN " or " Lonicerae and Forsythiae Powder "; Summer-heat damp cold, dispelling summer-heat from superficies of the body, conventional " Xiangru San " or " huoxiang zhengqi powder " etc.Over nearly 50 years, Chinese scholar is being made a large amount of research work aspect Traditional Chinese Medicine Anti influenza virus, result shows that Chinese medicine has good therapeutical effect to viral illness, particularly influenza, the Chinese medicines such as Herba Ephedrae, Ramulus Cinnamomi, Radix Isatidis, Folium Isatidis, Rhizoma Polygoni Cuspidati, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Fructus Arctii, Rhizoma Osmundae, Radix Bupleuri, Herba Houttuyniae, Rhizoma Et Radix Notopterygii, Rhizoma Belamcandae, Rhizoma Paridis, infected by influenza all has certain inhibitory action, and wherein Xin Wenxin medicine of a cold nature thing all has.This trickle research is perhaps helpful to pharmaceutical preparation, but with doctor trained in Western medicine the Theoretical Expatiation traditional Chinese medical science onset mechanism must be a blind alley, because the definition of Chinese medicine is taking tcm theory as basis, there are unique theoretical system and application form, some features of the aspects such as Natural Resources in China and history, culture are fully reflected, so people call it in " Chinese medicine ".So get hold of the basic of differentiation of tcm, could should make good use of the Chinese medicine of fever and chills and warm and cool, play effect as the effect of small wooden raft drum.

This product " children's's JINHUA cold granules " is proved recipe preparation, drawn ancient prescription Lonicerae and Forsythiae Powder, huoxiang zhengqi powder and Herba Sidae Rhombifoliae soup etc. elite and modern age preparation feature, particularly long-term a large amount of clinical practice, effective proved recipe of summary develops.Pharmacology prove this product have antiviral, antibacterial, bring down a fever, the multiple drug action such as antiinflammatory, pain relieving, clinical trial shows that this compound Chinese medicinal preparation clinical efficacy is remarkable.

Summary of the invention

The object of the invention is to provide a kind of compound Chinese medicinal preparation for the treatment of safely and effectively infantile common cold.

Another object of the present invention is to provide the preparation method of this compound Chinese medicinal preparation.

Compound Chinese medicinal preparation provided by the present invention is to be prepared from through extracting by the Chinese medicine of following part by weight: Flos Lonicerae 400 ~ 800g, Herba Houttuyniae 400 ~ 800g, Rhizoma Belamcandae 200 ~ 500g, Radix Bupleuri 200 ~ 500g, Herba Menthae 100 ~ 300g, the Rhizoma Anemarrhenae 100 ~ 300g, Radix Scrophulariae 100 ~ 400g, Herba Pogostemonis 100 ~ 400g.

The preparation method of compound Chinese medicinal preparation of the present invention, comprises the following steps:

Above eight tastes, get Herba Houttuyniae, Herba Menthae, Herba Pogostemonis, extraction by steam distillation volatile oil 6 ~ 24h, filter, the another device harvesting of water extraction liquid after distillation, is designated as aqueous extract I, beta-cyclodextrin inclusion compound for volatile oil (volatile oil: beta-schardinger dextrin-=1ml:2 ~ 20g), extracting honeysuckle, Rhizoma Belamcandae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Bupleuri decocts with water 3 times, 0.5 ~ 2 hour for the first time, 0.5 ~ 2 hour for the second time, 0.5 ~ 2 hour for the third time, merging filtrate, be designated as aqueous extract II, merge aqueous extract I and aqueous extract II, be concentrated into relative density 1.05 ~ 1.20 (60 DEG C), add appropriate ethanol to make ethanol content reach 50% ~ 80%, cold preservation 24 hours, make precipitation completely, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, be concentrated into thick original text, drying under reduced pressure, broken mistake 100 mesh sieves of dried cream powder, add appropriate dextrin, Icing Sugar and aspartame mix, granulate dry, after 16 mesh sieve granulate, add Benexate Hydrochloride, mix, granulation 1000g.

Compound Chinese medicinal preparation of the present invention, the phase is characterised in that, this compound preparation can add acceptable adjuvant on pharmaceutics to make various peroral dosage forms after mixing, as granule, pill, tablet, capsule etc.

Application provided by the present invention is that described compound Chinese medicinal preparation is in the application for the preparation of in treatment infantile common cold medicine.

Compound Chinese medicinal preparation of the present invention is taking Flos Lonicerae as monarch drug, can fresh breeze using warming therapy heat, separate the poison in blood.Herba Houttuyniae, Rhizoma Belamcandae, Radix Scrophulariae are ministerial drug altogether, heat-clearing and toxic substances removing, and inducing diuresis to remove edema, Yin-nourishing and body fluid promoting pathogenic fire reducing, relieving restlessness is quenched the thirst.Herba Menthae, the Rhizoma Anemarrhenae, Radix Bupleuri, Herba Pogostemonis function are adjuvant, wind-dispelling heat-dissipating, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, and the heat of letting out clearly lung stomach, relieving restlessness is slaked thirst and help produce saliva, clearing away heat and expelling pathogen in the exterior damp eliminating, the appetizing of being amusing.

By following test, the safety of curative effect of the present invention is further elaborated.

1, cure mainly relevant Pharmacodynamic test of active extract research with function:

According to " study of tcm new drug guide " and Xu Shuyun " pharmacological experimental methodology ", carry out curing mainly relevant Pharmacodynamic test of active extract with function, be summarized as follows:

1) antivirus action: use Flu virus FM ₁collunarium infecting mouse, sets up viral pulmonary infection mouse model, observes the protective effect of compound Chinese medicinal preparation to viral pulmonary infection mice.Result shows: in this compound Chinese medicinal preparation, high dose group can reduce the lung index (P<0.05 or 0.01) of influenza virus mice, in table 1, reduce mortality rate (P<0.05 or 0.01), the prolongation life span (P<0.05 or 0.01) of influenza virus A-prime Mus lung adapted strain (FM1) infecting mouse, in table 2; This compound Chinese medicinal preparation of observation in vitro is to herpes simplex virus I-form and influenza virus A ₃, B-mode, parainfluenza virus 1 type, coxsackie B family virus 5 type, respiratory syncytial virus effect.Result demonstration, this compound Chinese medicinal preparation energy direct killing herpes simplex virus-I type (HSV-I type), can suppress parainfluenza virus 1 type, coxsackie B family virus 5 type, the growth of respiratory syncytial virus, breeding; Infected by influenza first 3 and B-modely have a direct deactivation in vitro.

The impact of table 1 compound Chinese medicinal preparation on virus infected mice body weight and lung index ( ± s, n=10)

Compared with Normal group, * p<0.01; # p<0.05 compared with model group, ##P<0.01

The protective effect of table 2 compound Chinese medicinal preparation to virus infected mice ( ± s, n=20)

# p<0.05 compared with model group, ##P<0.01

2) bacteriostasis: cause infection model to mouse peritoneal injection staphylococcus aureus, observe the protective effect of this compound Chinese medicinal preparation.Result demonstration, this compound Chinese medicinal preparation has obvious protective effect (P<0.05) to the mice of infection of staphylococcus aureus; Use liquid tube dilution method, 8 kind of 72 strain common pathogen carried out to extracorporeal bacteria inhibitor test, antibacterial circle diameter exceedes 12 mm persons and has been considered as bacteriostasis, and record is subject to the minimum inhibitory concentration (MIC) of reagent to various bacterium, the results are shown in Table 3.Result demonstration, this compound Chinese medicinal preparation is stronger to the inhibitory action of the coccuses such as staphylococcus aureus, staphylococcus epidermidis, Diplococcus pneumoniae, Escherichia coli, and minimum inhibitory concentration is between 6.5 ~ 50.9mg crude drug/ml; Alpha streptococcus, proteus vulgaris, bacillus pyocyaneus, Bacillus typhi are also had to certain inhibition growth.

The average Mlc of table 3 compound Chinese medicinal preparation to various bacterium ( ± s)

3) antiinflammatory action: taking dimethylbenzene, Ovum Gallus domesticus album, sodium carboxymethyl cellulose, histamine etc. as proinflammatory agent, observe the antiinflammatory action of this medicine.Result shows, in this compound Chinese medicinal preparation, high dose group can suppress by the mice ear due to dimethylbenzene (P<0.05 or 0.01), in table 4, can suppress by rat toes swelling (P<0.05 or 0.01) due to Ovum Gallus domesticus album, in table 5; Leukoplania (P<0.01) in the rat abdominal cavity that can suppress to be caused by 1% sodium carboxymethyl cellulose, can the antagonism capillary permeability that amine causes in a organized way increase (P <0.05 or 0.01).Illustrate that this medicine has stronger antiinflammatory action.

Table 4 compound Chinese medicinal preparation xylol cause ear swelling impact ( ± s, n=10)

With relatively * P<0.05 of model group, * * p<0.01

4) antipyretic effect: taking yeast and escherichia coli endotoxin as pyrogen, observe the antipyretic effect of this medicine.Result shows, this compound preparation can reduce by the microbial rat temperature rising of yeast (P<0.01), can reduce the rabbit body temperature rising (P<0.05 or 0.01) that escherichia coli endotoxin causes, in table 6.Illustrate that this medicine has significant antipyretic effect.

Table 5 compound Chinese medicinal preparation on Ovum Gallus domesticus album cause the swelling of mice vola impact ( ± s, n=10)

With relatively * P<0.05 of model group, * * p<0.01

The impact of high hot rabbit anus temperature due to table 6 compound Chinese medicinal preparation induced by endotoxin ( ± s, n=6)

With relatively * P<0.05 of model group, * * p<0.01

5) analgesic effect: with mouse writhing method and hot plate method, observe the analgesic effect of this medicine.Result demonstration, this compound Chinese medicinal preparation can reduce the mouse writhing reaction (P<0.01) due to 0.5% acetic acid, in table 7, can extend the pain threshold of mice to hot plate induced pain, in table 8.Illustrate that this medicine has analgesic effect.

Table 7 compound Chinese medicinal preparation Dichlorodiphenyl Acetate cause mouse writhing reaction impact (( ± s, n=10)

With relatively * P<0.05 of model group, * * p<0.01

The impact of table 8 compound Chinese medicinal preparation on mice hot plate induced pain pain threshold ( ± s, n=10)

With relatively * P<0.05 of model group, * * p<0.01

2, the acute toxicity test of this compound Chinese medicinal preparation research

This compound preparation toxicity is low, does not measure LD50 value, with the dosage of Cmax (5.6g/ml), maximum volume (0.4ml/10g) to mouse stomach.One day twice, Continuous Observation 7 days, without dead mouse, maximum dosage-feeding was 448g crude drug/Kg on 1st, was equivalent to 320 times of clinical application amount, the internal organs such as the heart, liver, spleen, lung, kidney all do not find that under visible and microscope, visible toxic pathology changes.

To sum up, compound Chinese medicinal preparation of the present invention is safely and effectively.

3, clinical trial

Select 136 routine infantile common colds (upper respiratory tract infection), patient, be divided at random matched group and test group, every group of 78 examples, test group gives compound Chinese medicinal preparation cold granules of the present invention (preparation method: get Herba Houttuyniae, Herba Menthae, Herba Pogostemonis, extraction by steam distillation volatile oil 12h, filter, the another device harvesting of water extraction liquid after distillation, is designated as aqueous extract I, beta-cyclodextrin inclusion compound for volatile oil (volatile oil: beta-schardinger dextrin-=1ml:10g), extracting honeysuckle, Rhizoma Belamcandae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Bupleuri decocts with water 3 times, 2 hours for the first time, 2 hours for the second time, 0.5 hour for the third time, merging filtrate, be designated as aqueous extract II, merge aqueous extract I and aqueous extract II, be concentrated into relative density 1.15 (60 DEG C), add appropriate ethanol to make ethanol content reach 70%, cold preservation 24 hours, make precipitation completely, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, be concentrated into thick original text, drying under reduced pressure, broken mistake 100 mesh sieves of dried cream powder, add appropriate dextrin, Icing Sugar and aspartame mix, granulate dry, after 16 mesh sieve granulate, add Benexate Hydrochloride, mix, granulation 1000g, subpackage, every bag of 5g.), instructions of taking: 1～3 years old each 0.5 ~ 1 bag, 4～6 years old each 1 ~ 1.5 bag, 7～9 years old each 1.5～2 bags, 10 years old above each 2 bags, three times on the one, oral meal; Matched group gives Xiaoer shuangqing, the same investigational agent of dosage and instructions of taking.The courses for the treatment of 3 d.

The standard of drafting according to " new Chinese medicine guideline of clinical investigations (trying) " is carried out efficacy evaluation, the results are shown in Table 9.

The clinical observation on the therapeutic effect of table 9 compound Chinese medicinal preparation

Group	Recovery from illness	Effective	Effectively	Invalid	Effective percentage
						Test group	31	26	15	6	92.3% *
Matched group	30	21	12	15	80.8%

With relatively * P<0.05 of matched group

Test group curative effect is better than matched group, has statistical significance (P<0.05).

Detailed description of the invention

Below in conjunction with specific embodiment, preparation method of the present invention is further explained.

Embodiment 1

Treat a Chinese medicine compound composition of medicine for infantile common cold, comprise each component of following part by weight:

Flos Lonicerae 800g, Herba Houttuyniae 450g, Rhizoma Belamcandae 200g, Radix Bupleuri 500g, Herba Menthae 100g, Rhizoma Anemarrhenae 150g, Radix Scrophulariae 200g, Herba Pogostemonis 200g.

The preparation method of compound Chinese medicinal preparation of the present invention, comprises the following steps:

Above eight tastes, get Herba Houttuyniae, Herba Menthae, Herba Pogostemonis, and extraction by steam distillation volatile oil 6h filters, and the another device harvesting of water extraction liquid after distillation, is designated as aqueous extract I, beta-cyclodextrin inclusion compound for volatile oil (volatile oil: beta-schardinger dextrin-=1ml:5g), extracting honeysuckle, Rhizoma Belamcandae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Bupleuri decocts with water 3 times, each 1 hour, merging filtrate, be designated as aqueous extract II, merge aqueous extract I and aqueous extract II, be concentrated into relative density 1.05 (60 DEG C), add appropriate ethanol to make ethanol content reach 50%, cold preservation 24 hours, make precipitation completely, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, be concentrated into thick original text, drying under reduced pressure, broken mistake 100 mesh sieves of dried cream powder, add appropriate dextrin, Icing Sugar and aspartame mix, granulate dry, after 16 mesh sieve granulate, add Benexate Hydrochloride, mix, granulation 1000g.

Embodiment 2

Treat a Chinese medicine compound composition of medicine for infantile common cold, comprise each component of following part by weight:

Flos Lonicerae 600g, Herba Houttuyniae 500g, Rhizoma Belamcandae 200g, Radix Bupleuri 250g, Herba Menthae 300g, Rhizoma Anemarrhenae 300g, Radix Scrophulariae 400g, Herba Pogostemonis 300g.

The preparation method of compound Chinese medicinal preparation of the present invention, comprises the following steps:

Above eight tastes, get Herba Houttuyniae, Herba Menthae, Herba Pogostemonis, extraction by steam distillation volatile oil 10h, filter, the another device harvesting of water extraction liquid after distillation, is designated as aqueous extract I, beta-cyclodextrin inclusion compound for volatile oil (volatile oil: beta-schardinger dextrin-=1ml:8g), extracting honeysuckle, Rhizoma Belamcandae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Bupleuri decocts with water 3 times, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, merging filtrate, be designated as aqueous extract II, merge aqueous extract I and aqueous extract II, be concentrated into relative density 1.10 (60 DEG C), add appropriate ethanol to make ethanol content reach 60%, cold preservation 24 hours, make precipitation completely, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, be concentrated into thick original text, drying under reduced pressure, broken mistake 100 mesh sieves of dried cream powder, add appropriate dextrin, Icing Sugar and aspartame mix, granulate dry, after 16 mesh sieve granulate, add Benexate Hydrochloride, mix, granulation 1000g.

Embodiment 3

Treat a Chinese medicine compound composition of medicine for infantile common cold, comprise each component of following part by weight:

Flos Lonicerae 500g, Herba Houttuyniae 600g, Rhizoma Belamcandae 350g, Radix Bupleuri 350g, Herba Menthae 250g, Rhizoma Anemarrhenae 200g, Radix Scrophulariae 200g, Herba Pogostemonis 400g.

The preparation method of compound Chinese medicinal preparation of the present invention, comprises the following steps:

Above eight tastes, get Herba Houttuyniae, Herba Menthae, Herba Pogostemonis, extraction by steam distillation volatile oil 12h, filter, the another device harvesting of water extraction liquid after distillation, is designated as aqueous extract I, beta-cyclodextrin inclusion compound for volatile oil (volatile oil: beta-schardinger dextrin-=1ml:10g), extracting honeysuckle, Rhizoma Belamcandae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Bupleuri decocts with water 3 times, 2 hours for the first time, 2 hours for the second time, 0.5 hour for the third time, merging filtrate, be designated as aqueous extract II, merge aqueous extract I and aqueous extract II, be concentrated into relative density 1.15 (60 DEG C), add appropriate ethanol to make ethanol content reach 70%, cold preservation 24 hours, make precipitation completely, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, be concentrated into thick original text, drying under reduced pressure, broken mistake 100 mesh sieves of dried cream powder, add appropriate dextrin, Icing Sugar and aspartame mix, granulate dry, after 16 mesh sieve granulate, add Benexate Hydrochloride, mix, granulation 1000g.

Embodiment 4

Treat a Chinese medicine compound composition of medicine for infantile common cold, comprise each component of following part by weight:

Flos Lonicerae 400g, Herba Houttuyniae 400g, Rhizoma Belamcandae 300g, Radix Bupleuri 300g, Herba Menthae 300g, Rhizoma Anemarrhenae 300g, Radix Scrophulariae 300g, Herba Pogostemonis 300g.

The preparation method of compound Chinese medicinal preparation of the present invention, comprises the following steps:

Above eight tastes, get Herba Houttuyniae, Herba Menthae, Herba Pogostemonis, extraction by steam distillation volatile oil 18h, filter, the another device harvesting of water extraction liquid after distillation, is designated as aqueous extract I, beta-cyclodextrin inclusion compound for volatile oil (volatile oil: beta-schardinger dextrin-=1ml:16g), extracting honeysuckle, Rhizoma Belamcandae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Bupleuri decocts with water 3 times, 1.5 hours for the first time, 1.0 hours for the second time, 0.5 hour for the third time, merging filtrate, be designated as aqueous extract II, merge aqueous extract I and aqueous extract II, be concentrated into relative density 1.20 (60 DEG C), add appropriate ethanol to make ethanol content reach 80%, cold preservation 24 hours, make precipitation completely, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, be concentrated into thick original text, drying under reduced pressure, broken mistake 100 mesh sieves of dried cream powder, add appropriate dextrin, Icing Sugar and aspartame mix, granulate dry, after 16 mesh sieve granulate, add Benexate Hydrochloride, mix, granulation 1000g.

Claims (5)

1. treat a compound Chinese medicinal preparation for infantile common cold, it is characterized in that this compound preparation is to be prepared from through extracting by medicinal plants or the decoction pieces of following part by weight: Flos Lonicerae 400 ~ 800g, Herba Houttuyniae 400 ~ 800g, Rhizoma Belamcandae 200 ~ 500g, Radix Bupleuri 200 ~ 500g, Herba Menthae 100 ~ 300g, the Rhizoma Anemarrhenae 100 ~ 300g, Radix Scrophulariae 100 ~ 400g, Herba Pogostemonis 100 ~ 400g.

2. the compound Chinese medicinal preparation for the treatment of infantile common cold according to claim 1, is characterized in that said dosage form is said dosage form on any pharmaceutics.

3. the medicine for the treatment of infantile common cold according to claim 2, is characterized in that said dosage form is granule.

4. the preparation method of the granule for the treatment of infantile common cold according to claim 3, is characterized in that:

Above eight tastes, get Herba Houttuyniae, Herba Menthae, Herba Pogostemonis, extraction by steam distillation volatile oil 6 ~ 24h, filter, the another device harvesting of water extraction liquid after distillation, is designated as aqueous extract I, beta-cyclodextrin inclusion compound for volatile oil (volatile oil: beta-schardinger dextrin-=1ml:2 ~ 20g), extracting honeysuckle, Rhizoma Belamcandae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Radix Bupleuri decocts with water 3 times, 0.5 ~ 2 hour for the first time, 0.5 ~ 2 hour for the second time, 0.5 ~ 2 hour for the third time, merging filtrate, be designated as aqueous extract II, merge aqueous extract I and aqueous extract II, be concentrated into relative density 1.05 ~ 1.20 (60 DEG C), add appropriate ethanol to make ethanol content reach 50% ~ 80%, cold preservation 24 hours, make precipitation completely, filter, decompression filtrate recycling ethanol is extremely without alcohol taste, be concentrated into thick original text, drying under reduced pressure, broken mistake 100 mesh sieves of dried cream powder, add appropriate dextrin, Icing Sugar and aspartame mix, granulate dry, after 16 mesh sieve granulate, add Benexate Hydrochloride, mix, granulation 1000g.

5. compound Chinese medicinal preparation claimed in claim 1 is in the application for the preparation of in infantile common cold medicine.