Summary of the invention
The invention provides a kind of oral liquid and preparation method for the treatment of septicemia; The selected medical material compatibility of oral liquid of the present invention is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, can remove the toxin of pathogen secretion in blood and suppress germ reproduction, the effect with heat-clearing and toxic substances removing, anti-inflammatory analgetic, improve body's immunity, the septicemia causing for various cause of diseases is evident in efficacy, long action time, short treating period, instant effect, safe without toxic side effect, can be widely used in the clinical treatment of septicemia.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat an oral liquid for septicemia, raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Raw material composition and the parts by weight of making described oral liquid effective ingredient are:
Treat a preparation method for the oral liquid of septicemia, comprise following processing step:
(1) get Herba Taraxaci, Radix Angelicae Pubescentis, Herba Lophatheri, Folium Nerviliae fordii, Fructus Ulmus preparatium, Radix Arnebiae (Radix Lithospermi) and Herba Violae decontamination, clean and put into container, the distilled water that adds 7-9 doubly to measure, soaked after 3-4 hour, boiled 2-3 hour, extracted; Again add 4-6 doubly to measure distilled water, boil 1-2 hour, extract; Finally add 2-3 doubly to measure distilled water, heated and boiled 1-2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate for later use;
(2) get Semen Arecae and Radix Sophorae Flavescentis decontamination, microwave drying, is placed in mortar and grinds into powder, crosses 200 order fine powders, standby;
(3) get Radix Cirsii Japonici, Herba Artemisiae Annuae and Caulis Bambusae Germinatus decontamination and clean, smash juice, taking juice is standby;
(4) get Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Iridis, Ramulus Uncariae Cum Uncis and Radix Gentianae decontamination and clean, dry, add 85% alcoholic solution of 5 times of amounts, soak 2-3 hour, heating extraction 2 hours, recovered alcohol, filter, by the thick paste of relative density 1.15~1.25 under 60 ℃ of environment of filtrate simmer down to, standby;
(5) above-mentioned steps (1)-(4) prepared filtrate, fine powder, juice and thick paste are mixed, utilize modern advanced pharmacy science and technology, make oral liquid, be the oral liquid of described treatment septicemia.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Taraxaci: sweet in the mouth, micro-hardship, cold in nature.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Can be used for temperature disease, removing heat from the liver, treatment liver-heat conjunctival congestion and swelling pain, and multi-infection, purulent disease.Modern medicine study confirms, Herba Taraxaci has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus, and Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis are also had to certain bactericidal action.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature; Return liver, kidney, urinary bladder channel.Modern medicine study confirmation, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation.
Semen Arecae: bitter in the mouth, pungent, warm in nature; Return stomach, large intestine channel.Killing insect and eliminating accumulation, the capable water of sending down the abnormal ascending QI, preventing the attack (or recurrence) of malaria.For cestode, ascarid, fasciolopsiasis buski, abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, malaria.Modern medicine study confirmation, Semen Arecae infusion has inhibitory action in various degree to dermatophytess such as trichophytons in vitro, and decoct and some strain of water logging agent infected by influenza A type have certain inhibitory action.
Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae): acrid in the mouth, micro-hardship, cold in nature, malicious greatly; Return lung meridian.Heat-clearing and toxic substances removing, removing obstruction for relieving pain.Cure mainly influenza, leptospirosis, skin infection pain poison from the beginning of, scrofula, cellulitis, chronic osteomyelitis, poisonous snake flood dragon wound, malicious peak sting.
Herba Lophatheri: sweet in the mouth, light, cold in nature; Enter the heart, kidney two warps.Clearing away heart-fire, heat clearing away and restlessness relieving, diuresis.Control calentura thirsty, vexed, hot urination, stranguria with turbid discharge, erosion of the oral mucosa tongue boil, gingival swelling and pain.The < < SHENGCAO property of medicine is standby wants > > to carry: " expectorant is quenched the thirst, except part of the body cavity above the diaphragm housing the heart and lungs fire, and bright eyes, diuresis, controls nebulousurine, brings down a fever, loose hemorrhoid poison.”
Folium Nerviliae fordii: bitter in the mouth, sweet, property is flat.Clearing away lung-heat to relieve cough, spleen invigorating removing food stagnancy, sedation-analgesia, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For pulmonary tuberculosis cough spitting of blood, bronchitis, infantile malnutrition, infantile pneumonia, psychosis, treating swelling and pain by traumatic injury, stomatitis, acute laryngitis, sore.< < Simao, Yunnan Chinese herbal medicine selects > > to carry: " dissipating blood stasis for subsidence of swelling, sedation-analgesia.Control psychosis, traumatic injury, the swollen stasis of blood pain of knot.”
Ramulus Uncariae Cum Uncis: sweet in the mouth, cool in nature; Return liver, pericardium channel.Heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Be used for having a headache dizzy, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension.The newly organized > > of < < book on Chinese herbal medicine carries: " Ramulus Uncariae Cum Uncis, goes very speed of wind, has wind disease person must use it.But the life of wind-fire is many because of in deficiency of kidney-YIN, so that wooden dryness-fire is scorching, in YIN-tonifying drug, uses less Ramulus Uncariae Cum Uncis, and wind-fire is fugitive, if not nourishing YIN entirely, pure loose fiery to dispel the wind with Ramulus Uncariae Cum Uncis, wind can not cease, and fiery and more vehement.”
Semen Iridis: sweet in the mouth, property is flat.Heat-clearing and toxic substances removing, hemostasis.Cure mainly jaundice, dysentery, leucorrhea, carbuncle, sore throat, furuncle and phyma, anemofrigid-damp arthralgia, spits blood, epistaxis, the diseases such as metrorrhagia.
Fructus Ulmus preparatium: acrid in the mouth, property is flat.Parasite killing, removing food stagnancy.Cure mainly abdominal pain due to worm stagnation, children's's infantile malnutrition with diarrhea, cold-dysentery, scabies, malignant boil.Modern medicine study confirmation, Fructus Ulmus preparatium immersion (1:2) has inhibitory action in various degree to 12 kinds of dermatophytess such as trichophyton, Microsporon audouinis in vitro.
Radix Cirsii Japonici: sweet in the mouth, hardship, cool in nature, nontoxic; GUIXIN, Liver Channel.Cure mainly haematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, acute appendicitis, carbuncle and ulcer toxic swelling, furuncle.Modern medicine study confirmation, the aqueous solution of Radix Cirsii Japonici has anesthetic action; Radix Cirsii Japonici has facilitation to the generation of thrombokinase, and can suppress pathogenic bacteria generation.
Radix Arnebiae (Radix Lithospermi): sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel.Removing heat from blood and promoting blood circulation, removing toxic substances rash.For heat in blood poison, contain, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Modern medicine study confirmation, Radix Arnebiae (Radix Lithospermi) has extremely slight inhibitory action to acute lymphoblastic leukemia.
Herba Artemisiae Annuae: bitter in the mouth, pungent, cold in nature; Return liver, gallbladder meridian, three warmers, kidney channel.Clear deficiency-heat thoroughly, removing heat from blood is except steaming, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.Modern medicine study confirmation, Herba Artemisiae Annuae has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, and staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc. are also had to certain inhibitory action.
Radix Gentianae: bitter in the mouth, cold in nature; Return liver, gallbladder meridian.Heat clearing away eliminating pathogen in the liver, arresting convulsion.For jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, the feeling of fullness in the head headache of liver and gall excess-fire, conjunctival congestion and swelling pain, deaf ear is swollen, hypochondriac pain bitter taste, calentura convulsion with spasms.
Caulis Bambusae Germinatus: sweet in the mouth, cold in nature.The relieving distension of reducing phlegm.For rash, long-pending abdominal distention, varioliform exanthema does not go out.The < < detailed outline > > that picks up any lost article from the road carries, and " saliva that reduces phlegm, helps digestion swollen for sharp nine orifices, promoting blood circulation.”
Herba Violae: bitter in the mouth, pungent, cold in nature; GUIXIN, Liver Channel.Heat-clearing and toxic substances removing, removing heat from blood detumescence.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature; Return liver, kidney, large intestine, small intestinal, the heart, urinary bladder channel.Heat clearing and damp drying, parasite killing diuresis.Be widely used in multiple humidifier fever, as damp-heat dysentery; External can be decocted soup washout, for hemorrhoid, and women gynecological; Modern medicine study confirmation, Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus, and Radix Sophorae Flavescentis water logging agent has inhibitory action to trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly budlet spore tinea bacterium difficult to understand etc.
The present invention compared with prior art, has following beneficial effect:
The selected medical material compatibility of oral liquid of the present invention is suitable, meet Chinese medicine and modern medicine research theory, and adopt modern advanced medical pharmaceutical technology to make, can remove the toxin of pathogen secretion in blood and suppress germ reproduction, the effect with heat-clearing and toxic substances removing, anti-inflammatory analgetic, improve body's immunity, the septicemia causing for various cause of diseases is evident in efficacy, long action time, short treating period, instant effect, safe without toxic side effect, can be widely used in the clinical treatment of septicemia.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of oral liquid effective ingredient of the present invention forms and weight is:
The preparation method of oral liquid of the present invention, comprises following processing step:
(1) get Herba Taraxaci, Radix Angelicae Pubescentis, Herba Lophatheri, Folium Nerviliae fordii, Fructus Ulmus preparatium, Radix Arnebiae (Radix Lithospermi) and Herba Violae decontamination, clean and put into container, the distilled water that adds 7-9 doubly to measure, soaked after 3-4 hour, boiled 2-3 hour, extracted; Again add 4-6 doubly to measure distilled water, boil 1-2 hour, extract; Finally add 2-3 doubly to measure distilled water, heated and boiled 1-2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate for later use;
(2) get Semen Arecae and Radix Sophorae Flavescentis decontamination, microwave drying, is placed in mortar and grinds into powder, crosses 200 order fine powders, standby;
(3) get Radix Cirsii Japonici, Herba Artemisiae Annuae and Caulis Bambusae Germinatus decontamination and clean, smash juice, taking juice is standby;
(4) get Rhizoma Alocasiae Cucullatae (Rhizoma Alocasiae Macrorrhizae), Semen Iridis, Ramulus Uncariae Cum Uncis and Radix Gentianae decontamination and clean, dry, add 85% alcoholic solution of 5 times of amounts, soak 2-3 hour, heating extraction 2 hours, recovered alcohol, filter, by the thick paste of relative density 1.15~1.25 under 60 ℃ of environment of filtrate simmer down to, standby;
(5) above-mentioned steps (1)-(4) prepared filtrate, fine powder, juice and thick paste are mixed, utilize modern advanced pharmacy science and technology, make oral liquid, be the oral liquid of described treatment septicemia.
Usage and dosage: oral, each 20ml, every day 3 times, 7 days is a course for the treatment of, and can fully recover 3 to 4 courses for the treatment of; The person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Embodiment 2
The raw material of oral liquid effective ingredient of the present invention forms and weight is:
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage are identical with embodiment 1.
Embodiment 3
The raw material of oral liquid effective ingredient of the present invention forms and weight is:
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage are identical with embodiment 1.
Embodiment 4
The raw material of oral liquid effective ingredient of the present invention forms and weight is:
The present embodiment Chinese drugs agentia preparation method processing step and usage and dosage are identical with embodiment 1.
Clinical data:
1, case selection:
As the oral liquid for the treatment of septicemia, select septic patient 85 examples to carry out clinical observation, patient is divided into two groups at random, treatment group 43 examples, male 23 examples wherein, women's 20 examples, age 0-60 year, 32.5 years old mean age, disease time 1-15 days; Matched group 42 examples, male 21 examples wherein, women's 21 examples, age 0-60 year, 31.8 years old mean age, course of disease 1-15 days; Two groups of patient medical record are basically identical, without significant difference, have comparability, all keep on a diet on request for two groups.
2, Therapeutic Method:
Patient for treatment group applies oral liquid of the present invention, oral, and each 20ml, every day 3 times, 7 days is a course for the treatment of, takes continuously 3 to 4 courses for the treatment of and can fully recover, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
The patient of matched group applies penicillin, gives the symptomatic treatments such as warming, oxygen supply, vasoactive drug simultaneously.By specification use, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
3, curative effect judgement:
Cure: the septicemia transference cures such as shiver with cold, high heat, tachycardia, rapid breathing, erythra, arthralgia and hepatosplenomegaly, health immune function improves.
Take a turn for the better: above-mentioned symptom alleviates to some extent, and health immune function increases.
Invalid: symptom is unchanged.
4, therapeutic outcome:
Treatment group: cure 33 examples, 8 examples that take a turn for the better, invalid 2 examples, cure rate is 76.7%, total effective rate is 95.3%.
Matched group: cure 19 examples, 11 examples that take a turn for the better, invalid 12 examples, cure rate is 45.2%, total effective rate is 71.4%.
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
5, model case is for example:
(1) Lee, man, 20 years old, university students, Distributions in Liaocheng of Shandong Province people.Patient is admitted to hospital because of nose face ache, and mound shape protuberance appears in the patient right side wing of nose, owing to repeatedly pushing, occurs that upper lip buccal portion is red and swollen, and tenderness is positive, with low grade fever.AD is that boil of the nose merges buccal cellulitis, give antiinflammatory symptomatic treatment, occur high heat, headache next day, 40 ℃~41 ℃ of body temperature, patient's mind is indifferent, drowsiness, Ipsilateral eyelid and conjunctiva are without edema, and papilla of optic nerve is without edema, numeration of leukocyte is 3.1 * 109/L, blood antibacterial culturing is infection of staphylococcus aureus, after be diagnosed as the concurrent septicemia of boil of the nose, proceed to medical treatment.Give a large amount of antibiotic, induced hibernation, adrenocortical hormone and do not feel any better, occur that pulse is thin and delicate, rapid breathing, hepatosplenomegaly.Rear patient uses oral liquid of the present invention, takes 4 courses for the treatment of, and recovery from illness, has no recurrence.
(2) Xu certain, female, people from Changzhi, Shanxi.Raw latter 7 days of patient, the about 2.5kg of body weight, Low Response, does not take food, do not cry, Dermal icterus, complexion is steel gray, and sclerosis of the skin outside buccal portion, buttocks and two upper and lower extremities, can not pinch with hands, and have pitting edema, hepatosplenomegaly, heart rate is slow, and hear sounds is low blunt, and body temperature does not rise.Blood routine examination total white blood cells reduces, 4 * 10g/L, and neutrophilic granulocyte band form nucleus 21%, c reactive protein increases, and is diagnosed as septicemia of newborn.Take oral liquid of the present invention after 3 courses for the treatment of, recovery from illness, has no recurrence.
(3) poplar, man, 32 years old, workman, Pingliang, Gansu people.There is heating without obvious inducement in patient, body temperature fluctuates in 38 ℃~39 ℃, and with headache, feel sick, vomiting, the locality conventional WBC19 * 10g/L that has a blood test, N86.3%; Waist is worn CSF and is checked: cranium is pressed 200mmH2O, and sugar, albumen slightly raise, and chloride is lower slightly, and respiratory rhythm is obviously accelerated, and two pulmonary respiration sounds are thick.Clinical diagnosis is septicemia, and patient takes after 3 course of therapy of oral liquid of the present invention, conditions of patients recovery from illness.
(4) together certain, man, 46 years old, businessman, Tianjin Nankai people from district.Patient is admitted to hospital because of heating, double knee joint and waist and sacrum pain, body temperature between 38 ℃~40 ℃, the performance that apnea road infects, urine, just as usual, without skin infection history.Passive flexing position while coming institute, anemia, skin, mucosa have no petechia, superficial lymph knot does not touch, conjunctiva is pale, and the heart, lung check no abnormality seen, and the liver upper bound is at right midclavicular line the 6th intercostal, lower bound is 2cm under rib, matter is soft, and spleen does not touch, and clinical diagnosis is septicemia, patient takes after 3 course of therapy of oral liquid of the present invention, conditions of patients recovery from illness.