CN101607067A - A kind of Chinese medicine preparation and preparation method for the treatment of cholelithiasis - Google Patents

A kind of Chinese medicine preparation and preparation method for the treatment of cholelithiasis Download PDF

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CN101607067A
CN101607067A CNA2009100171682A CN200910017168A CN101607067A CN 101607067 A CN101607067 A CN 101607067A CN A2009100171682 A CNA2009100171682 A CN A2009100171682A CN 200910017168 A CN200910017168 A CN 200910017168A CN 101607067 A CN101607067 A CN 101607067A
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fructus
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herba
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袁玲玲
薛伟
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Abstract

The invention discloses a kind of Chinese medicine preparation for the treatment of cholelithiasis, it is characterized in that, the ratio of weight and number of various components is: 10～20 parts of Fructus Aurantiis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Lysimachiaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Evodiaes, 10～20 parts in Natrii Sulfas, 10～20 parts of HUOXUEDAN, 10～20 parts of Endothelium Corneum Gigeriae Galli, 10～20 parts of Spica Prunellaes, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Radix Clematidis, 10～20 parts of Fructus Crataegis, 10～20 parts of Herba Scutellariae Barbataes, 10～20 parts of Spora Lygodii, 10～20 parts in Rhizoma Curcumae Longae, 10～20 parts in Poria.The present invention has depressed liver-energy dispersing and function of gallbladder promoting, the stagnant blood stasis dispelling of row, promoting blood circulation to remove obstruction in the collateral, the effect of calculus dissolving and excreting.And advantages such as the medicament preparation method is easy, and is with low cost.

Description

A kind of Chinese medicine preparation and preparation method for the treatment of cholelithiasis
Technical field
The present invention relates to contain medicinal preparation that derives from plant, animal or mineral component and preparation method thereof, particularly a kind of Chinese medicine preparation and preparation method for the treatment of cholelithiasis.
Background technology
In recent years since China living standards of the people improve, the change of dietary habit, environmental factors changes, the sickness rate of cholelithiasis is the trend that rises year by year.About the origin cause of formation of cholelithiasis, modern medicine thinks it mainly is that cholesterol and cholate are out of proportion, or the cholesterol ratio is higher, or the cholate ratio is on the low side, causes cholesterol can not normally be dissolved in the cholate and due to being separated out.Its disease is equivalent to traditional Chinese medical science hypochondriac pain category." Ling Shu Miraculous Pivot or Divine Axis five pathogenic factors " piece of writing is said: " evil in liver, then in two sides of body bitterly." " element is asked a wrong thorn opinion piece of writing " say that also " pathogen invading in the collateral of Foot-SHAO YANG makes us the hypochondriac pain being unable to breathe freely." traditional Chinese medical science always more thinks to invade in the exopathogen, or drinking and eating irregularly, so that insufficiency of the spleen resulting in production of dampness, damp-stagnancy is given birth to heat, damp and hot decocting and forming.But " element is asked and lifted a pain opinion piece of writing " said: " the cold visitor is in the arteries and veins of the moon of fainting blood tears swift pulse then, so coerce rib and lack abdomen dragging pain mutually." as seen, insufficiency of the spleen resulting in production of dampness is given birth to expectorant, chance is trembled with fear and is condensed into calculus, and the visitor hinders the liver and gall mechanism of qi to make it must not declare freely in the normal pulse foot collaterals of SHAO YANG of the moon of fainting, and is one of main origin cause of formation of primary disease.
Cholesterol is oils and fats and so on, and meeting trembles with fear then coagulates, and gets Wen Zehua, is to dredge profit and can control it with temperatureization.In fact, clinical every cholelithiasis patient that sees, how not obvious resembling that it is damp and hot be, and instead with lethargy, extremity are not warm, light red tongue, the fur white-greasy patients is in the majority.Therefore adopt warming for eliminaring cold-damp, dredge sharp liver and gall and every can the Qin effect.
Operation is the main means of treatment cholelithiasis, but still has some problems: (1) has certain operative mortality and complication; (2) postoperative remnant gallstone rate height; (3) old or have other serious disease corrective surgeries dangerous big; (4) the part patient fears operation or refusal hands art; (5) doctor wishes that also some case do not treat by operation repeatedly again; (6) medical expense is bigger.Therefore, it is significant that active research is used non-surgical treatment.
Non-surgical treatment has at present: through scope biliary tract stone extraction, extracorporeal shock-wave lithotomy and medicine lithodialysis, calculus.To carry out vater's papilla through the scope biliary tract stone extraction and cut, belong to the invasive treatment; Extracorporeal shock-wave lithotomy only can have certain damage to hepatic tissue, and need combine with lithodialysis, lithagogue method at big cholelithiasis more than the 2.0cm, otherwise rubble is divided a word with a hyphen at the end of a line at biliary tract and easily caused and block and infect.The medicine litholytic therapy is divided into oral drugs lithodialysis and direct dabbling drug lithodialysis.Oral drug therapy be the easiest, to the Therapeutic Method of the basic no pain of patient, yearned for by people always.
As far back as nineteen thirty-seven Neubridge at first with the method for oral bile acid treatment cholelithiasis, but up to the end of the sixties because the origin cause of formation of bile metabolism and cholelithiasis has had deep understanding, oral drugs litholytic method is just developed.Up to the present the oral drugs lithodialysis also only limits to the dissolving cholesterol calculus, and clinical effectiveness is poor.The main medicine of using has: (1) chenodeoxycholic acid (Chenodeoxycholicacid CDCA), can enlarge the cholic acid pond, and reduce the saturation of bile cholesterol.But dosage is big, and the course of treatment is long, external 2 years complete molten rates of calculus only 13.5%, and the calculus regeneration rate is 25-50% after the drug withdrawal.Prolonged application is toxic to liver, part patient's diarrhoea, and low density lipoprotein, LDL increases in the blood, causes arteriosclerosis.(2) ursodesoxycholic acid (Ursodeoxycholic acid UDCA): litholytic effect is good than CDCA, and does not have the above-mentioned side effect of CDCA.But the expense costliness, the course of treatment is also very long, and the lithodialysis rate about 40% in external 2 years, recurrence of hepatolithiasis rate 16-33% after the drug withdrawal.(3) treatment by Chinese herbs: traditional Chinese medical herbal treatment cholelithiasis all was based on the anti-discharging calculus of function of gallbladder promoting in the past, thereby tens kinds of cholagogic and lithagogue soup are arranged.Its effect mainly is depressed liver-energy dispersing and function of gallbladder promoting, clearing away heat-damp and promoting diuresis, activating blood circulation to dissipate blood stasis.The mechanism of action may be: the expansion choledochal sphincter, promote row's gallbladder function, and increase choleresis, shrink gallbladder, lax Qddis sphincter increases biliary tract wriggling and anti-inflammation.
One of treatment means of cholelithiasis has direct perfusion lithodialysis, be about to the lithodialysis agent through T pipe (postoperative) or keep somewhere nose bile duct or percutaneous through scope and inject biliary system through liver etc., it is sure making the lithodialysis agent directly contact the effect that cholelithiasis touches the lithodialysis agent, but the screening of dissolved stone medicine also need deeply be inquired into, the characteristics of this method are: medicine can directly contact with cholelithiasis, can be without liver metabolism, it is fast to produce effects, and artificial control is easy to do.
Treatment by Chinese herbs is higher to the clinical symptom remission rate of cholelithiasis, but lithagogue rate and to arrange quiet rate many below 30%.In a word, the oral drugs lithodialysis will have new progress, waits further effort.China's Chinese medicine and natural animal-plant aboundresources studies show that the volatile oil component that contains the alkene terpenoid in the Chinese medicine has litholytic effect, but the research of the litholytic effect of other constituents is less.So develop a kind of depressed liver-energy dispersing and function of gallbladder promoting that has, the stagnant blood stasis dispelling of row, promoting blood circulation to remove obstruction in the collateral, the Chinese medicine preparation of the effect of calculus dissolving and excreting has very important significance.
Summary of the invention
Technical problem to be solved by this invention is that at present gallstone treatment relapse rate height, the halfway shortcoming of lithodialysis provides a kind of Chinese medicine preparation for the treatment of cholelithiasis and preparation method thereof.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of cholelithiasis, the ratio of weight and number of its various components is: 10～20 parts of Fructus Aurantiis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Lysimachiaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Evodiaes, 10～20 parts in Natrii Sulfas, 10～20 parts of HUOXUEDAN, 10～20 parts of Endothelium Corneum Gigeriae Galli, 10～20 parts of Spica Prunellaes, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Radix Clematidis, 10～20 parts of Fructus Crataegis, 10～20 parts of Herba Scutellariae Barbataes, 10～20 parts of Spora Lygodii, 10～20 parts in Rhizoma Curcumae Longae, 10～20 parts in Poria.
The Chinese medicine preparation of described treatment cholelithiasis, the ratio of weight and number of various components can be preferably: 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Herba Lysimachiaes, 10～15 parts of Radix Curcumaes, 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Evodiaes, 10～15 parts in Natrii Sulfas, 10～15 parts of HUOXUEDAN, 10～20 parts of Endothelium Corneum Gigeriae Galli, 10～20 parts of Spica Prunellaes, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Radix Clematidis, 10～20 parts of Fructus Crataegis, 10～20 parts of Herba Scutellariae Barbataes, 10～20 parts of Spora Lygodii, 10～20 parts in Rhizoma Curcumae Longae, 10～20 parts in Poria.
The Chinese medicine preparation of described treatment cholelithiasis, the ratio of weight and number of various components also can be preferably: 10～20 parts of Fructus Aurantiis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Lysimachiaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Evodiaes, 10～20 parts in Natrii Sulfas, 10～20 parts of HUOXUEDAN, 10～15 parts of Endothelium Corneum Gigeriae Galli, 10～15 parts of Spica Prunellaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Herba Artemisiae Scopariaes, 10～15 parts of Fructus Toosendans, 10～15 parts of Radix Clematidis, 10～15 parts of Fructus Crataegis, 10～15 parts of Herba Scutellariae Barbataes, 10～15 parts of Spora Lygodii, 10～15 parts in Rhizoma Curcumae Longae, 10～15 parts in Poria.
The Chinese medicine preparation of described treatment cholelithiasis, the parts by weight of various components also can be preferably than being: 15～20 parts of Fructus Aurantiis, 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Herba Lysimachiaes, 15～20 parts of Radix Curcumaes, 15～20 parts of Radix Bupleuri, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts of the Radix Paeoniae Albas, 15～20 parts of Fructus Evodiaes, 15～20 parts in Natrii Sulfas, 15～20 parts of HUOXUEDAN, 15～20 parts of Endothelium Corneum Gigeriae Galli, 15～20 parts of Spica Prunellaes, 15～20 parts of Radix Scutellariaes, 15～20 parts of Herba Artemisiae Scopariaes, 15～20 parts of Fructus Toosendans, 15～20 parts of Radix Clematidis, 15～20 parts of Fructus Crataegis, 15～20 parts of Herba Scutellariae Barbataes, 15～20 parts of Spora Lygodii, 15～20 parts in Rhizoma Curcumae Longae, 15～20 parts in Poria.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of cholelithiasis, and its preparation method may further comprise the steps:
A. described component is pulverized the back and add ethanol, heating and refluxing extraction 3 times;
B. 3 extracting solution are merged, reclaim ethanol, concentrate sucking filtration after adsorption resin column absorption;
C. with deionized water or distilled water eluting, the reuse ethanol elution is collected ethanol elution, removes alcohol solvent, obtains component medicated powder, incapsulates and is made as capsule after adsorbing.
The preparation method of the Chinese medicine preparation of described treatment cholelithiasis among the step a, can be pulverized described component the back and add 10 times of amount ethanol, and heating and refluxing extraction 3 times is heated to be 2 hours at every turn.
The preparation method of the Chinese medicine preparation of described treatment cholelithiasis, among the step b, after 3 extracting solution can being merged, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, when the relative density of filtrate is 20 ℃ 1.08, described filtrate flow is the adsorption resin column absorption of 10L through volume.
The preparation method of the Chinese medicine preparation of described treatment cholelithiasis, among the step c, after can adsorbing with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.
The Chinese medicine preparation of described treatment cholelithiasis can be fried in shallow oil decoction in use and take, and 1 dose of every day, decocting is obeyed at twice, and per 30 days is a course of treatment; Can be each 5 when capsule uses, every day three times, per 20 days is a course of treatment.
Its dosage form of the Chinese medicine preparation of described treatment cholelithiasis can be: honey refining pill, hydration pill, capsule, tablet, drop pill, syrup, powder, slow releasing pharmaceutical, controlled release drug, oral liquid medicine, gel, soft extract, extractum or membrane.
Compared with prior art, the present invention has clear superiority: the present invention has tangible depressed liver-energy dispersing and function of gallbladder promoting, the stagnant blood stasis dispelling of row, promoting blood circulation to remove obstruction in the collateral, the effect of calculus dissolving and excreting.And advantages such as the medicament preparation method is easy, and is with low cost.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, and toxic and side effects is little, and is easy to use, and healing time is short, cures the back and is difficult for recurrence.Can create good social is worth and economic interests.
The specific embodiment
Primary disease belongs to liver and gall and loses in accent and reach, and catharsis is unfavorable, and turbid YIN failing to descend decocts and coalescently forms calculus or muddy stone is stranded in the gallbladder, hinders mechanism of qi.Think that and above all disease traditional Chinese medical science occurs gallbladder and liver be with tool catharsis function, with lead to reduce to suitable.Primary disease is many by disorder of emotion, five excessive emotions converting into internal fire, and liver and gall are lost in catharsis, and pent-up forms.Or because of depressed liver and heat transmission or surfeit delicious food, spleen lose fortuneization, damp and hot strongly fragrant for a long time, move heat in the gallbladder internal organs, decoct bile, become sandstone, block biliary tract, so that the gallbladder internal organs is obstructed, thereby generation biliary colic, i.e. what is called " stagnation of QI and blood may bring about pain ".The Chinese medicine depressed liver-energy dispersing and function of gallbladder promoting makes the gas of liver and gall fluent, i.e. the meaning of " disease caused by accumulations of pathogen should be treated with therapy of dispersion "; Dampness-heat in the liver and gallbladder, gallbladder internal organs not general rule gives clearing heat secreting bile, pathogenic fire purging relieving constipation, i.e. " internal organs is to lead to for suitable ".
How to effect a radical cure cholelithiasis? Chinese medicine truly has justifiable advantage.The traditional Chinese medical science is thought, cholelithiasis, and sick position is involved in liver at gallbladder, and is also closely related with taste.So treatment is not limited to disease position or calculus size and quantity, be not limited to the well-established law of depressed liver-energy dispersing and function of gallbladder promoting, and the magic weapon of utilization determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is divided into damp-heat accumulation, expectorant stasis of blood friendship resistance, deficiency of both QI and YIN, deficiecny of liver-YIN etc., verification system side's medication respectively to common pattern of syndrome.Cholelithiasis, sick position is involved in liver at gallbladder, and also closely related with middle burnt taste, clinical witness has excess syndromes such as stagnation of liver-QI gallbladder-heat, liver and gall or damp-heat in the spleen and stomach, and the native empty Herba Equiseti Hiemalis's card due to the weakness of the spleen and stomach is also arranged, and shows as cold-damp in addition, the soil due to stagnant etc. is stopped up wooden melancholia.Common again because of taking bitter cold or the special side of hot dry thin profit or the medicine impairment of body fluid hematozemia of heat-clearing and toxic substances removing for a long time, cause deficiecny of liver-YIN, the obstinate person.In recent years, behind operation on biliary tract, the hepatic duct retained calculus, or among the patient of postoperative recurrence, see the pattern of syndrome of deficiecny of liver-YIN especially more, the sequitur operation has the fraud of the liver-yin of injuring.So Chinese traditional treatment cholelithiasis more should be noted the utilization of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs,
For many years, Chinese scholars has been carried out a large amount of research work to the perfusion dissolved stone medicine, and the result of laboratory and clinical research shows, how cholelithiasis and chronic cholecystitis easily betided between 40～60 years old, and the men and women all can fall ill.Right side of body flank belongs to liver and gall two warps, because of the arteries and veins of two warp follows the capable flank of coercing.The liver happiness is transferred and is reached, but the gallbladder catharsis.Any reason causes that suffocating of liver and gall is unfavorable, as turbid YIN failing to descend, decocts and coalescently forms calculus or muddy stone is stranded in the gallbladder, hinders mechanism of qi, venation is obstructed, and blood stasis is stagnated, and venation is lost and supported, and all can cause coercing flank pain, being blood tears swift pulse, is that blood is puckery unfavorable, and sering is promptly not smooth.Stagnation of QI due to depression of the liver is violated and taste, dysfunction of the spleen in transportation, and gastric qi is lost and is fallen, and distension and fullness in the abdomen occurs, belch, poor appetite is weak.Pathogenic fire derived from stagnation of liver-QI is bitter taste then, yellowish or reddish urine or low grade fever is arranged.With the passing of time the stagnation of QI blood stasis must occur, and right side side of body flank and epigastric pain are fixed, and the tenderness limitation can be laid one's hand on and the gallbladder of enlargement, the stagnation of liver-QI functional activity of QI being not smooth, and stagnation of blood stasis, often because of mood change, appetite does not save, particularly after the surfeit delicious food greasy food and bring out and increase the weight of.The clinical manifestation of cholelithiasis how based on pain in the right hypochondrium, is drawn and the right shoulder back of the body.
The present invention is its characteristics to pay attention to ascending or descending movement of vital Qi, and irritability rises from a left side, must rely the respectful of lung qi to fall, and lung qi falls from right, also must rely the liter of irritability to send out, both mutual causality of ascending and descending, it wherein is the pivot of rising and falling of QI that taste occupy, and is keeping human life activity's dynamic equilibrium jointly." the typhoid fever hypochondriac pain belongs to shaoyang channel and is subjected to heresy, uses Herba Sidae Rhombifoliae soup, mixes and demonstrate,proves hypochondriac pain; a left side is a disharmony in liver-QI, uses bupleurum powder for relieving liver-qi, and XIAOYAO POWDER is used in seven emotions pent-up; as if liver-fire, phlegm retention, food stagnation, the blood stasis of holding concurrently, and with the card dosing, heresy is moved in lung for liver in the right side; with ' it is diffusing to push away gas ', all excess syndrome hypochondriac pains of controlling, Radix Curcumae is used with Fructus Aurantii, the right side in a left side; the agent that is all, and so also has deficiency and coldness to have a pain, and gets warm then diffusing; feeling pain while pressing ends, and suitable again temperature compensation can not be also rigid." prescription of the present invention is with warming for eliminaring cold-damp, it is main dredging sharp liver and gall.Group's temperature medicines such as Fructus Evodiae, Radix Salviae Miltiorrhizae, Fructus Crataegi, with warming for eliminaring cold-damp, promoting the circulation of QI to relieve pain; Flat Herba Lysimachiae of additivity and the Herba Artemisiae Scopariae that is slightly cold again.Herba Lysimachiae, Spora Lygodii, Radix Curcumae, Fructus Toosendan, Radix Bupleuri, Radix Angelicae Sinensis lead to and fall calculus with depressed liver-energy dispersing and function of gallbladder promoting, and Endothelium Corneum Gigeriae Galli lithodialysis fossil is to remove silt.The heat of Radix Scutellariae, Radix Bupleuri liver heat removing gallbladder; Poria, Radix Paeoniae Alba regulating the stomach and sending down the abnormal ascending QI relieving spasm to stop pain, the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the yin nourishing of HUOXUEDAN blood circulation promoting and enriching is in case cloudy blood consumption is hindered, and all medicine compatibilities have depressed liver-energy dispersing and QI regulating, the blood stasis dispelling calculus, removing obstruction in the collateral to relieve pain, the logical merit of falling of heat clearing away is with cholagogic and lithagogue.
Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.
HUOXUEDAN: return liver; Gallbladder; Urinary bladder channel, it is treating stranguria to have a dampness removing; Heat-clearing and toxic substances removing; The effect of dissipating blood stasis for subsidence of swelling; Cure mainly the pyretic stranguria stranguria caused by urinary stone; Jaundice due to damp-heat; Sore, carbuncle and painful swelling; Tumbling down damage dampness removing stranguria-relieving medicinal; It is heat and toxic materials clearing away medicine simply; Dissipating blood stasis for subsidence of swelling good medicine.
Herba Artemisiae Scopariae: cold nature, acrid in the mouth, hardship.Return spleen, stomach, liver, gallbladder meridian.The function clearing away damp-heat, the jaundice eliminating subcutaneous ulcer.Be used for jaundice oliguria, eczema pruritus.
Spora Lygodii: cold in nature, sweet in the mouth.Return bladder, small intestine meridian.Function cures mainly: eliminating damp-heat, treating stranguria pain relieving.Be used for pyretic stranguria, sand Stranguria, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.
Herba Lysimachiae: cold nature, sweet in the mouth, salty.Function cures mainly clearing away heat-damp and promoting diuresis, and is treating stranguria, detumescence.Be used for pyretic stranguria, sand Stranguria, urine is puckery has a pain, the jaundice dark coloured urine, the carbuncle furuncle, venom, liver and bile stone, lithangiuria, outstanding kind treatment stranguria caused by urinary stone disease is fried in shallow oil for the tea-drinking clothes but single is dense, or is equal to usefulness with Spora Lygodii, Endothelium Corneum Gigeriae Galli.Herba Lysimachiae has the effect of cholagogic and lithagogue and diuresis and expelling stone, and very strong calculus effect is arranged.Show that with the experimental calcium oxalate renal calculus of Tinea Ranae model test it is effective for prevention and the experimental renal calculus of treatment Tinea Ranae that Herba Lysimachiae is fried in shallow oil juice.Anesthesia Canis familiaris L. semi open model recording system experimental result shows that Herba Lysimachiae can cause that ureter epimere cavity pressure increases, and ureteral peristalsis strengthens, and the urine amount increases, and ureteral calculus is had extruding and percussion, impels ureteral calculus to discharge.Calcium oxalate (CaC2O4) monohydrate is the main component of lithangiuria, polysaccharide component in the alcohol-insoluble substances of Herba Lysimachiae, crystalline growth to Calcium oxalate (CaC2O4) monohydrate has inhibitory action, and inhibitory action increases with the increase of concentration, and normal person's urine is suitable to the effect of inhibitory action and 1.94 * 10 (5) g (the crude drug)/polysaccharide that ml extracted of Calcium oxalate (CaC2O4) monohydrate crystalline growth.Adopt conductive method, find that refining polysaccharide suppresses Calcium oxalate (CaC2O4) monohydrate crystalline growth percentage rate and is higher than decocting liquid precipitate with ethanol part.
Radix Curcumae: hot, bitter, cold.Return liver, the heart, lung meridian.The function regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine." book on Chinese herbal medicine just " carries it: emesis blood, epistaxis; Single the knot gather qi together stagnates with controlling married woman's cold air accumulation of blood, and the trusted subordinate has a pain." book on Chinese herbal medicine is stated ": control heating, strongly fragrant, cough, bleeding from the gum, cough blood, hematuria, it is dizzy have a headache, mad epilepsy, dysentery, pouring, and card such as eyes nose glossopharyngeum larynx.
Natrii Sulfas: salty, bitter, cold.Return stomach, large intestine channel.The function purging heat to relax the bowels, moistening for dryness and softening hard mass, the detumescence of relieving inflammation or internal heat.Be used for the excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swells and ache; The external treatment acute mastitis, swelling and pain of hemorrhoid.Can be used for obstructive jaundice and chronic cholecystitis.
Fructus Toosendan: nature and flavor are cold in nature, bitter in the mouth; Slightly poisonous.The function soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.Be used for the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation." property of medicine opinion " carries it: " big heat is mad among the owner, and it is hot-tempered vexed to lose the heart, makes soup and bathes." " pearl sac ": " Your Majesty bottom stomachache, heart sudden pain." " the medical center bun is wanted ": " eliminating heart-fire, hard kidney water, lung heat clearing gold, clearing away liver-fire.Nuclear: happy hernia, remove syndrome of aversion to cold lasting day and night with cold limbs.″
Fructus Aurantii: bitter, hot, sour, temperature.Return spleen, stomach warp.The function regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Be used for the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion stops in the phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus." Bencao Jingshu ": Fructus Aurantii, abnormal smells from the patient is led, and is identical generally with Fructus Aurantii Immaturus.But Fructus Aurantii Immaturus shape is little, and its gas is complete, and its property is strong, so kind assigning; Fructus Aurantii shape is big, and its gas looses, and its property is slow, and Gu Qihang is slow slightly, is with the branch of able person's chest and diaphragm lung stomach and goes into large intestine also.Its main air paralysis of itching, easing joint movement ends wind pain person, covers lung governing skin and hair, stomach master muscle, wind and cold wets in two warps, skin pruritus then, or have a pain, or numb, this medicine has hardship to let out hot diffusing merit, doublely can draw all wind medicines and go into two dirtyly, so required for controlling wind, ailment said due to cold or exposure is both loose, and then saves the nature tonneau.It treats the consumptive disease cough, the bored and listless person of back of the body arm, and lid also refers to that wind and cold is strongly fragrant in the part of the body cavity above the diaphragm housing the heart and lungs, then lung qi stagnates and is bored and listless cough." warp " said: the lung being apt to suffer from adverse rising of QI, anxious food bitter flavor having purgating effect, the Fructus Aurantii bitter in the mouth can be let out paramount gas, so lead also.Lung and large intestine are the exterior and the interior again, and ailment said due to cold or exposure is gone into lung, then incorporate large intestine into, and wind heat is fought mutually and is discharging fresh blood stool, the gas of letting out under the bitter cold, and then clear the and wind of heat in blood is from removing.Its main loosing stays blocked-up chest phlegm in the diaphragm to stagnate, and relieves oedema or abdominal distension through diuresis or purgation, and relieving distension is full, all cards of peace stomach, know identical with Fructus Aurantii Immaturus, the slow slightly ear of its gas.This life is many in order to control married woman's nausea uneasiness, or to eight, JIUYUE is the easily agent of product, and is available easily, hardly realizes married woman's pregnancy, the full QI and blood that relies is with fetus nourishing, then tire is from easily producing for the QI and blood abundance, and the woman to eight that is pregnent, JIUYUE spirit are sleepy, tetraparesis, diet reduces, the dyspnea with rapid and short breath of moving breath, what is is it possible that the disease of weakness, and more with the medicine of this dissipation?
Rhizoma Curcumae Longae: hot, bitter, temperature.Return spleen, Liver Channel.Function cures mainly removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Be used for the breast side of body and twinge, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.Rhizoma Curcumae Longae has splendid choleretic effect: Rhizoma Curcumae Longae extract, curcumin, volatile oil, turmerone and zingiberene, Borneolum Syntheticum and sesquiterpenoid etc., choleretic effect is all arranged, can increase biliary generation and secretion, and can promote gallbladder to shrink, and the strongest with acting as of curcumin.
The Radix Paeoniae Alba: go into the nourishing blood to suppress the hyperactive liver of liver spleen channel, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia." herbal classic " carries it: " main pathogen stomachache is removed arthralgia due to stagnation of blood, and is broken hard long-pending, controls cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." " not Lu " carries it: " clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when (controlling), attacked by pestiferous factors stomachache, lumbago." " property of medicine opinion " carries it: " controls pathogen of the lung gas, Fu Zhong Xu pain, and vim and vigour are gathered, and the logical internal organs of declaring are gathered around gas, control evil pain deteriorated blood, disease bone heat when main, strong the five internal organs, the kidney invigorating gas, it is hard bloated to control the trusted subordinate, and married woman's blood closes obstructed, and repercussive blood can lose pus.″
Spica Prunellae: bitter, hot, cold.Liver heat removing, eliminating stagnation, diuresis; Control diseases such as pestilence, acute mastitis, ophthalmalgia, jaundice, gonorrhea, hypertension; Leaf can be for tea.Control that lymphoid tuberculosis, thyromegaly, scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia are shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Relieve inflammation or internal heat and make eye bright: control conjunctival congestion and swelling pain, headache.Clearing away liver-fire, blood pressure lowering: control hypertension; Mass dissipating and swelling eliminating: control scrofula, goiter, acute mastitis the southern regions of the Yunnan Province book on Chinese herbal medicine that swells and ache ": the liver-wind of dispelling, the network of passing through is controlled facial hemiparalysis.Its row irritability is opened stagnation of liver-QI, ends bones and muscles pain, ophthal malgia, and the scrofula of loosing is stolen, whole body tuberculosis." the SHENGCAO property of medicine fully will " carries it: remove the expectorant pus that disappears, control scrofula, clear going up mended down, removes eye mask, pain relieving." Bencao Congxin " carries it: control scrofula, scrofula, goiter, disease heavily fortified point, acute mastitis, breast carcinoma.
Radix Clematidis: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the hypochondriac lump of loosing.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Tang Materia Medica carries it: waist, kidney, foot knee joint, gather, all cold diseases of enteral, be not recovered the effect of clothes for many years." Kaibao Bencao " carries it: main all wind, and interior cold the stagnating of abdomen gone in the Xuan Tongwu Tibetan, and septum cordis expectorant water is long-pending for a long time, lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, the cold painful treatment folding that reaches of waist knee joint is hindered.Because of its property is walked to scurry, the pharmacology confirms that it removes esophagus, bronchus, ureter, stomach and biliary tract etc. in addition and locate the effect of smooth muscle spasm, and stronger anti-inflammatory analgetic effect is arranged, and therefore, finds out its many new wonderful recipes of using in the clinical practice again." Bencao Jingshu ": Radix Clematidis, main all wind, and be that should leading of wind medicine is apt to away the person also.Cold stagnating in the abdomen, many because cold-damp, heart phlegm in the diaphragm water, be drink be stopped at, in two Jiao also, wind energy wins and wets.Damp disease happiness is dry, thus lead also.Bladder place pus aversion to water wastes and can't help wet institute and becomes, and the waist knee joint is cold painful, and also the edge portion of flowing down that wets invades muscle and causes it, expelling wind and removing dampness, and disease is with going.It is said for a long time long-pending lump in the abdomen, mass beside the umbilicus, air parcel and folding and hinders.Then sick many in the blood system person, the edema caused by disorder of QI person is few, and may not be all because wet, and probably also not having of executing worked as, and here get joint can be also.
Fructus Evodiae: hot, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.The function dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be used for headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, the vomiting acid regurgitation is had loose bowels the external treatment aphtha just before dawn; Hypertension." not Lu " carries it: main expectorant is cold, angor in the abdomen, and Zhu Lengshi does not disappear, attacked by pestiferous factors, cardiac and abdominal pain, contrary gas, sharp the five internal organs." property of medicine opinion " carries it: main trusted subordinate's disease, and accumulation of pathogenic cold, stagnation of QI under the heart, chronic infectious disease is pained; Control cramp caused by acute vomiting and diarrhea, cold in the stomach gas, the stomachache of vomiting and diarrhoea can not win the person of bearing; Treat insensitive impediment all over, cold drinks and snachs does not disappear, and sharp large intestine is gathered around gas.
Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.The function heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement." medicine origin ": Radix Scutellariae, be in harmony damp and hot in the lung, swollen red in the hot order in the treatment, contain on the blood stasis ridge, the medicine that must use.Letting out in the lung fire ascending abnormally to the upper in every last, mend wing cold never foot all of a sudden, is to grow its change source." curing mainly secret formula " cloud, it is with having nine: eliminating the pathogens from the lung is through heat, and one also; Xia Yuexu usefulness, two also; The part of the body cavity above the diaphragm housing the heart and lungs and skin phoenix heat, three also: go all heat, four also; Married woman puerperal, sun is moved back in foster resistance, and five also; Profit is gas in the heart, and six also; Disappear every last expectorant, seven also; It is wet to remove part of the body cavity above the diaphragm housing the heart and lungs heat and spleen, and eight also; Antiabortive, nine also.Single system, two is made, is not made, and divides upper, middle and lower also.Wine is fried up, Your Majesty portion hematocele, and non-this can not remove, the lung being apt to suffer from adverse rising of QI, anxious food bitter flavor having purgating effect is just being called this also.
Fructus Crataegi: the traditional Chinese medical science thinks that Fructus Crataegi has effects such as removing food stagnancyization stagnates, convergence dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.Contain ingredients such as mountain terpenoid and pyrite class in the Fructus Crataegi, have significant blood vessel dilating and hypotensive effect, the function that strengthens cardiac muscle, arrhythmia, blood lipid regulation and cholesterol level is arranged." Bencao Jingshu ": Fructus Crataegi, the air cooling of " herbal classic " cloud sour in the mouth, so see its can help digestion long-pending, clots absorbing blood, then gas is non-cold.Having stagnates then becomes dysentery, prolonged lochia, and holding in lunar part then is after-pains.Fructus Crataegi can go into the taste removing food stagnancy and stagnate, and the stagnated blood that looses is so piece is bitterly also in harness the river dysentery and the puerpera's abdomen.On the whole its merit is longer than the dissipating fluid-retention food, strengthening the spleen and stomach, row stagnation of QI, repercussive blood.
Radix Bupleuri: hardship is slightly cold.Return liver, gallbladder meridian.Function is brought down a fever soothing liver-QI, yang invigorating with curing mainly to evacuate.Be used for cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Be soothing the liver good medicine of fostering the spirit of nobility.
Herba Scutellariae Barbatae: little hardship, cold.Cure mainly heat clearing away, detoxifcation, dissipating blood stasis, hemostasis, haematemesis is controlled in analgesic therapy, epistaxis, stranguria with blood, bloody dysentery, jaundice is had sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom.Modern pharmacology studies show that Herba Scutellariae Barbatae has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, antitoxin venom.
Endothelium Corneum Gigeriae Galli: sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli contains gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.Behind the oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and the stomach motion is strengthened, emptying is accelerated.
Poria: sweet, light, equal, return lung, stomach, kidney channel.That drug effect relieves internal heat is anticancer, diuretic dissipating fluid-retention, spleen invigorating mind calming.Promoting diuresis to eliminate damp pathogen, spleen invigorating is reduced phlegm, all Poria of using of mind tranquilizing and the heart calming, its purpose is to mend not lie in and lets out, and the effect of Poria is to let out and does not lie in benefit.The institute of lid gas extremely, water also penetrates everywhere, the institute of gas ends, water does not also have institute incessantly, so its water Xingqi gas of profit is also.Poria can mind calming the strengthening the spleen the kidney invigorating, with the tangible water of its row, the invisible gas of cloth is also.The diuretic circulation of qi promoting rises cloudyly with from sun, and the cloth sun to be changing the moon, gives birth to turbid falling in order to do clear, reaches descendingly outward, is able to tonification also and heart spleen kidney three is dirty.Poria is light and can ooze, and Gan Erneng mends, can rush down and can mend, two must its should medicine also.Diuretic is wet with the swollen dysuria of harnessing the river, and the drink that reduces phlegm is gone into the disease of network to control cough, phlegm-damp, strengthening the spleen and stomach and can the antidiarrheal leukorrhagia stopping, and mind calming god controls palpitation with fear and has a sleepless night.The property of medicine is gentle, does not have the fraud of hindering healthy energy, can set upright with it, again can be eliminating evil, so insufficiency of the spleen leading to overabundance of dampness, the disease of vital QI being weakened and pathogen being violent is particularly suitable.
The Chinese medicine that adopts the present invention to make has clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and function of gallbladder promoting, regulate the flow of vital energy treating stranguria and diuresis, promotion bile secretion, antiinflammatory, analgesia, effect such as analgesic, antibiotic, be used for the treatment of cholelithiasis, the lithangiuria particularly disease of type such as syndrome of qi stagnation and blood stasis or syndrome of dampness-heat diffusing downward or the liver and bile stone disease due to the syndrome of dampness-heat of liver and gallbladder, and upper right abdomen pain, upper abdomen distension, feel sick, anorexia is greasy, jaundice, yellowish fur or symptoms such as lumbago, hematuria, determined curative effect does not have obvious adverse reaction.
The manufacturing process of the present invention's honey refining pill is: get Fructus Aurantii 1500g, Radix Salviae Miltiorrhizae 1500g, Herba Lysimachiae 1500g, Radix Curcumae 1500g, Radix Bupleuri 1500g, Radix Angelicae Sinensis 1500g, Radix Paeoniae Alba 1500g, Fructus Evodiae 1500g, Natrii Sulfas 1500g, HUOXUEDAN 2000g, Endothelium Corneum Gigeriae Galli 2000g, Spica Prunellae 2000g, Radix Scutellariae 2000g, Herba Artemisiae Scopariae 2000g, Fructus Toosendan 2000g, Radix Clematidis 2000g, Fructus Crataegi 2000g, Herba Scutellariae Barbatae 2000g, Spora Lygodii 2000g, Rhizoma Curcumae Longae 2000g, Poria 2000g.Medical material was soaked 30 minutes to 1 hour, and heated and boiled 30 minutes is filtered filtrate for later use; Filtering residue adds water, and heating was boiled 30 minutes for the second time, refiltered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the third time, filters; Three filtrates are lumped together, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, and powdered being mixed in Mel of oven dry postcooling is twisted into slice; With every 5g is ball wax seal packing.
The manufacturing process of capsule of the present invention is: get Fructus Aurantii 2000g, Radix Salviae Miltiorrhizae 2000g, Herba Lysimachiae 2000g, Radix Curcumae 2000g, Radix Bupleuri 2000g, Radix Angelicae Sinensis 2000g, Radix Paeoniae Alba 2000g, Fructus Evodiae 2000g, Natrii Sulfas 2000g, HUOXUEDAN 2000g, Endothelium Corneum Gigeriae Galli 1500g, Spica Prunellae 1500g, Radix Scutellariae 1500g, Herba Artemisiae Scopariae 1500g, Fructus Toosendan 1500g, Radix Clematidis 1500g, Fructus Crataegi 1500g, Herba Scutellariae Barbatae 1500g, Spora Lygodii 1500g, Rhizoma Curcumae Longae 1500g, Poria 1500g add 10 times of amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrate is about 1.08 (20 ℃); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes solvent, obtains the component medicine earlier; Incapsulate and be made as capsule, every capsules dress 0.3g.Can per 12 be a plate.
The manufacturing process of tablet of the present invention is: with Fructus Aurantii 2000g, and Radix Salviae Miltiorrhizae 2000g, Herba Lysimachiae 2000g, Radix Curcumae 2000g, Radix Bupleuri 2000g, Radix Angelicae Sinensis 2000g, Radix Paeoniae Alba 2000g, Fructus Evodiae 2000g, Natrii Sulfas 2000g, HUOXUEDAN 2000g, Endothelium Corneum Gigeriae Galli 2000g, Spica Prunellae 2000g, Radix Scutellariae 2000g, Herba Artemisiae Scopariae 2000g, Fructus Toosendan 2000g, Radix Clematidis 2000g, Fructus Crataegi 2000g, Herba Scutellariae Barbatae 2000g, Spora Lygodii 2000g, Rhizoma Curcumae Longae 2000g, Poria 2000g joins described medicine chopping in the multi-function extractor, and the water logging that adds 3000g was steeped 30～40 minutes, decoct after 1.5 hours, decoction liquor is standby for the first time in taking-up; After the decocting of medicinal residues adding 3000g boils 1 hour, take out decoction liquor for the second time, twice decoction liquor merged filter, filtrate decompression is concentrated into the solution that ratio of weight and number is 1000g, staticly settled 24～36 hours, draw supernatant, add starch 3000g after being heated to 40～50 ℃, heating is concentrated into pasty state, put into baking oven, be controlled at 80 ℃, oven dry postcooling, film-making, drying, molding, packing.Can each hundred be one bottle of packing.Take each 3 every day three times.
Chinese medicine preparation pharmacodynamic study of the present invention:
At present, two kinds of cholelithiasis animal experimental models of domestic main employing: a kind of is that people's cholelithiasis is implanted in the animal gallbladder, observes the variation of calculus and the influence of Chinese and western drugs; Another kind is to bring out with bait.The former mainly is applicable to the experimentation of cholagogic and lithagogue, is unwell to the research of gallstone formation and anti-stone; Though the latter can be used as the research of anti-stone, observing time is longer, generally more than at least 2 months.Abroad, Scott and Lee utilize the lincomycin subcutaneous injection successfully to bring out the Cavia porcellus cholelithiasis, and gallstone formation rate is 87%, and close with people's black calculus composition.The experiment of Lee shows, after the injection lincomycin, B-glucuronidase activity and aminohexose content improve constantly in the Cavia porcellus gall bladder bile, laboratory animal gallbladder tissue learns and checks that showing as epithelial cell destroys hypertrophy, produce ulcer on the mucosa, glandular hyperplasia, mucous secretion increases, epithelial cell that comes off and mucus group become the core that cholelithiasis generates, and these characteristics are similar to the pathological process of human pigment calculus.Therefore, we select for use this method successfully to make the cholelithiasis animal model, and method is simple, and the time, only about 1 month, gallstone formation rate was also higher.
By to experimental group and matched group
Experimental technique: get 40 of healthy guinea pigs about body weight 500g, the male and female dual-purpose is divided into each 20 of experimental group and matched groups at random.According to the characteristics of Cavia porcellus, adopt the method for group feeding to feed.After normal 1 week of nursing, begin to apply the processing factor.Respectively at thigh root subcutaneous injection lincomycin hydrochloride, calculate by every kg body weight 60mg, injected continuously 7 days.Injection lincomycin same day, the experimental group animal is irritated with Chinese medicine preparation of the present invention, calculates by every kg body weight 16g crude drug, and every Cavia porcellus is irritated 2kg/L biliary tract calculus mixture 4ml at every turn; Matched group is irritated by the same method with normal saline 4ml.The continuous irrigation stomach is after 5 weeks, and it is deadly that Cavia porcellus is tapped the head, and cuts open the belly, and the ligation cystic duct takes out gallbladder, observes gallbladder and becomes the stone situation, and measure the content of cholic acid, total bilirubin, UCB and calcium ion in the bile.
Detection method: 1. write down the body weight and the nutriture of each treated animal different times, cut open kill after, observe thickness, the coarse and smooth degree of gallbladder wall, biliary color, transparency, precipitate and become the stone situation.2. the bile cholic acid is measured with the furfural method; Bile total bilirubin and bilirubin direct are measured with the diazonium method, and calculate unconjugated bilirubin (unconjugated bilirubin, abbreviation UCB) amount; Bile calcium is with the E.D.T.A1 titration measuring.3. statistical method: gallstone formation rate adopts the V2 check, and the content of cholic acid, total bilirubin, UCB and calcium ion adopts the t check to carry out statistical procedures.Body weight and nutriture: experimental group and control animals all have losing weight in various degree with experimentation.The experimental group animal is the suitable reason of hair from start to finish, and is glossy and fine and close; And control animals is mixed and disorderly, withered, sparse and matt in beginning to occur hair the 3rd week, and mobility is significantly less than experimental group, and it is also less to take food.
The gallbladder wall situation: 20 Cavia porcelluss all have in various degree thickening of capsule wall of gallbladder, coarse in the matched group; And 20 Cavia porcelluss are except that 4 gallbladder walls thicken slightly in the experimental group, and all the other gallbladder walls are all transparent, smooth.
Become the stone situation in the gallbladder: matched group has has silt particle sample calculus to form (85%) in 17 gallbladders, and experimental group only has and has a small amount of silt particle sample calculus to form (20%) in 4 gallbladders.Learn by statistics and handle, experimental group and matched group gallstone formation rate relatively have highly significant difference (P＜0.01).
Cholelithiasis is qualitative: through cholelithiasis qualitative analysis fast, experimental group and matched group cholelithiasis are the bilins calculus.
Bile color and transparency: experimental group animal intracapsular bile of gallbladder is all more limpid transparent, the coloured gold Huang; And how muddy the control animals intracapsular bile of gallbladder is, and color is dark yellow.
Bile component is analyzed: the results are shown in Table 1
The table 1 bile components analysis (Lmol of x ± s)
Cholic acid Total bilirubin ??UCB Calcium
Experimental group ??564.75±95.46 ??28.16±4.43 ??3.56±0.72 ??6.671±0.352
Matched group ??258.47±54.38 ??52.35±5.83 ??6.28±1.09 ??10.439±0.468
Compare with matched group, difference has the meaning (P＜0.01) of highly significant.
By experimental group and control animals intracapsular bile of gallbladder are carried out biochemical quantitative analysis, found that in the experimental group animal gall bladder bile cholic acid content apparently higher than matched group, and bilirubin, UCB and calcium ion content are starkly lower than matched group.Observed result shows in addition, and the Animal nutrition situation of taking biliary tract calculus mixture is good than matched group, and the tissue pathologies change of gallbladder wall is also slighter.Therefore we think that tentatively the mechanism of action of the anti-stone of biliary tract calculus mixture may be by improving hepatocyte function; adjust and keep metabolic normalizations such as bilirubin, B-glucuronidase in bile component ratio and the animal body; particularly by increasing the secretion and the drainage of cholic acid; the dissolubility of unconjugated bilirubin is increased; thereby prevented the generation of lithogenic bile and the imbalance of homergy, stoped the experimental probability that the stone factor produces calculus in animal body that causes.
Below be method and the result who uses pharmacodynamic experiment, acute toxicity testing and irritant experiment that the sample of prescription of the present invention and method preparation carries out.Pharmacodynamic experiment of the present invention reaches the influence to biochemical indicator and internal organs
Experimental technique: 10 of New Zealand white rabbit, male and female half and half, body weight 2.0kg～2.5kg, fasting is 12 hours before the art, is divided into 2 groups at random.Every example is got 2 pieces in people's cholelithiasis sample, is divided into 2 groups after the pairing at random.Anesthesia back aseptic condition is inserted each one piece in rabbit gallbladder, fistulation, indwelling drug infusion catheter.Pour into capsule of the present invention and normal saline contrast respectively by fistula catheter after one week.Each 0.5ml/kg body weight, 1 time/day.Put to death respectively after one week, get in the gallbladder and weigh after residual stone drying, the constant weight.Get the following biochemical indicator of hematometry: glucose (GLU), glutamate pyruvate transaminase (ALT), blood urea nitrogen (BUN).Take off the row internal organs and do pathologic finding: gallbladder, liver, pancreas, stomach, small intestinal, heart, brain, kidney, spleen, lungs.
Experimental result: after (1) one week, the calculosis that capsule administration group is inserted all dissolves.Matched group calculus weight does not have significant change.
(2) the basic no change of every biochemical indicator before and after the laboratory animal administration.
(3) the laboratory animal brain after the potting compound wafer, heart, lungs, gastrointestinal tract, kidney, liver, spleen, pancreas, gallbladder all do not have obvious pathological change.
The lithodialysis experimental result shows in the animal body, and Chinese medicine preparation provided by the present invention (capsule) directly lithodialysis agent can make the human gallstones of implanting in the rabbit gallbladder dissolve fully, and the every biochemical indicator and the internal organs of laboratory animal be there is no influence.
2. the acute toxicity test of Chinese medicine preparation of the present invention.
Experimental technique: 60 of kunming mices, body weight 18-22g is divided into 6 groups at random, 10 every group.Behind the 4h, give capsule respectively and irritate stomach on an empty stomach, dosage is every 10g body weight 0.32,0.36,0.40,0.44,0.49,0.54ml.
Experimental result: only 0.44 group of dead mouse is 1.All the other each groups all do not have dead.Show this capsule high safety.
3. the mucomembranous pungency test of capsule.
Experimental technique: get capsule and do the rabbit conjunctival stimulation test.Respectively capsule and normal saline are splashed in rabbit left eye and the right eye.Observe rabbit and have or not scratch reaction and conjunctiva variation.
Experimental result: rabbit does not have the reaction of obviously scratching.Observe 24 hours rabbit conjunctivals and do not have untoward reaction such as obvious hyperemia.
Above pharmacodynamic experiment and toxicological experiment result illustrate that Chinese medicine preparation of the present invention is a kind of safe, direct lytic agent of cholelithiasis efficiently.
Embodiment 1: Lee, and the male, body constitution is fair, 43 years old.Right side side of body flank pain is radiated to the shoulder back, distension and fullness in the abdomen, and belch is felt sick, and poor appetite is weak, bitter taste, yellowish or reddish urine.Fatigue, surfeit plumpness, greasy food or angry back above-mentioned symptom obviously increase the weight of annual recurrence two to three times.Sometimes recur pain unbearably, be right side volume clinostatism more during outbreak, accompany vexedly, feel bad.Check: right rib can be laid one's hand on down and the gallbladder of enlargement, tenderness under the right rib of limitation, and no rebound tenderness, flank position percussion pain is coerced on the right side.Red tongue, yellow fur are greasy slightly, stringy pulse and tight.Ultrasound diagnosis: gallbladder is enlargement slightly, major diameter 8.2cm, and transverse diameter 4cm is a plurality of cholelithiasis 0.3～0.5cm, gallbladder wall thickness, crude.Liver function: glutamate pyruvate transaminase 50umol/L, total bilirubin 22umol/L, bilirubin direct 18umol/L, unconjugated bilirubin 7umol/L.Routine blood test: leukocyte 11.8 * 109/L, neutral 74.8%.Once with cholelithiasis and cholecystitis treatment.With sodium ampicillin 6g intravenous drip, every day 2 times, 654～2,10mg, every day 2 times, symptomatic treatments such as intramuscular injection can only alleviating pain, and are bad during fashion.Because of recurrence again after fatigue, the greasy food of edible oil, increase the weight of by disease, pain is unbearably.The traditional Chinese medical science is thought: side of body rib is position, liver and gall place, and the disease of side of body rib belongs to liver and gall two warps, and this onset of disease mostly is the stagnation of QI, is the persistence distending pain, paroxysmal aggravation sometimes.The stagnation of QI is obstructed, consolidates to scurry and has a pain, so pull and the right side shoulder back of the body.Irritability stasis influences taste, dysfunction of the spleen in transportation, and distension and fullness in the abdomen appears in the stomach failing to send downwards, feels sick, and poor appetite is weak.Pathogenic fire derived from stagnation of liver-QI, bitter taste then, yellowish or reddish urine, with the passing of time symptoms such as low grade fever, the stagnation of QI cause blood stasis, right side side of body flank pain occurs and pull and take on the back.Sign: right side of body flank has slight percussion pain, can lay one's hand on and the gallbladder of enlargement, and the tenderness limitation is fixing.Method of treatment: depressed liver-energy dispersing and QI regulating, blood stasis dispelling calculus, removing obstruction in the collateral to relieve pain.Use prescription of the present invention as follows: Fructus Aurantii 20g, Radix Salviae Miltiorrhizae 20g, Herba Lysimachiae 20g, Radix Curcumae 20g, Radix Bupleuri 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 20g, Fructus Evodiae 10g, Natrii Sulfas 15g, HUOXUEDAN 20g, Endothelium Corneum Gigeriae Galli 20g, Spica Prunellae 10g, Radix Scutellariae 15g, Herba Artemisiae Scopariae 20g, Fructus Toosendan 20g, Radix Clematidis 15g, Fructus Crataegi 20g, Herba Scutellariae Barbatae 20g, Spora Lygodii 20g, Rhizoma Curcumae Longae 20g, Poria 15g.Use one the course of treatment patient right side side of body flank pain be radiated to the shoulder back, abdominal distention, belch, poor appetite is weak, bitter taste, symptoms such as yellowish or reddish urine subtract greatly, appetite increases.Imitate not more method, keep 45 doses of former sides again, right side side of body flank tenderness, percussion pain disappears, gallbladder do not lay one's hand on and, spiritual appetite is good.Routine blood test is normal.B ultrasonic: gallbladder size is normal, and calculus reduces 80% with preceding comparing.Liver function: glutamate pyruvate transaminase, total bilirubin, bilirubin direct is normal.Follow up a case by regular visits to not recurrence in 3 years.
Embodiment 2: leaf, and the woman, 51 years old, occur upper left abdomen first and continue to have an intense pain, pain is drawn the left side shoulder back of the body.Be diagnosed as the multiple calculus of gallbladder through CT, color ultrasound examination, calculus maximum gauge 112 * 119mm.Check: BP17/11kPa, the cardiopulmonary auscultation is no abnormal, and abdomen is soft, and epigastrium has tenderness slightly, the not enlargement of liver spleen, hemogram is normal, and amylase in urine slightly raises, light red tongue, tongue is greasy in vain, stringy pulse.Control with warming for eliminaring cold-damp depressed liver-energy dispersing and function of gallbladder promoting, promoting the circulation of QI to relieve pain.Use prescription of the present invention: Fructus Aurantii 20g, Radix Salviae Miltiorrhizae 20g, Herba Lysimachiae 20g, Radix Curcumae 20g, Radix Bupleuri 15g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Fructus Evodiae 10g, Natrii Sulfas 15g, HUOXUEDAN 20g, Endothelium Corneum Gigeriae Galli 20g, Spica Prunellae 15g, Radix Scutellariae 15g, Herba Artemisiae Scopariae 20g, Fructus Toosendan 20g, Radix Clematidis 15g, Fructus Crataegi 20g, Herba Scutellariae Barbatae 20g, Spora Lygodii 10g, Rhizoma Curcumae Longae 20g, Poria 15g.B ultrasonic check demonstration calculus is dwindled after using three courses of treatment continuously, and quantity reduces.Follow up a case by regular visits to half a year, do not hear recurrence.
Embodiment 3: the Qin, woman, 36 years old.Tell and suffered from left and right common hepatic duct, gallbladder, choledocholithiasis 3 years, surgical calculus removing 2 times.Upper right abdomen pain, tenderness appear again the bimester of postoperative.B ultrasonic shows left and right common hepatic duct, common hepatic duct, gallbladder, common bile duct popularity calculus, and the calculus maximum gauge is 118 * 112mm.Disease is seen: tired mind, and shallow complexion is not generated heat, and extremity are not warm, and hemogram slightly raises, light red tongue, tongue is white thick greasy, stringy and rolling pulse.Control with warming for eliminaring cold-damp, dredge sharp liver and gall, use prescription of the present invention: Fructus Aurantii 20g, Radix Salviae Miltiorrhizae 15g, Herba Lysimachiae 20g, Radix Curcumae 10g, Radix Bupleuri 15g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Fructus Evodiae 15g, Natrii Sulfas 15g, HUOXUEDAN 20g, Endothelium Corneum Gigeriae Galli 20g, Spica Prunellae 15g, Radix Scutellariae 15g, Herba Artemisiae Scopariae 20g, Fructus Toosendan 20g, Radix Clematidis 15g, Fructus Crataegi 15g, Herba Scutellariae Barbatae 20g, Spora Lygodii 10g, Rhizoma Curcumae Longae 20g, Poria 15g.3 doses of pain show a year work and alleviate, 15 doses of transference cures of continuous clothes.Advise and obeyed 10 doses of we in every month, do not seen recurrence so far half a year.
Clinical data shows that this organizes 30 examples, is clinic case, male's 22 examples, women's 8 examples, maximum 59 years old age, minimal ages 32 years old, average 47.6 years old.The course of disease: 6 months 10 examples, 6 months to 1 year 8 examples, 12 examples more than 1 year.B ultrasonic: cholelithiasis is many between 0.3cm～0.6cm, and thickening of capsule wall of gallbladder is crude.Liver function: the highest 50umol/L of glutamate pyruvate transaminase, total bilirubin 23umol/L, bilirubin direct 10umol/L, unconjugated bilirubin 12umol/L.Clinical cardinal symptom right side side of body flank pain is radiated to the shoulder back, and is uncomfortable in chest, and distension and fullness in the abdomen is felt sick, and poor appetite is weak, bitter taste, and yellowish or reddish urine, how the above-mentioned symptom recurrence increases the weight of sometimes after tired, anger or greasy, the cool food of surfeit plumpness, sometimes the emotion irritability.Modern medical diagnosis: cholelithiasis and chronic cholecystitis.
Therapeutic Method: Chinese medicinal formulae of the present invention is decocted in water for oral dose, and divides and takes for 2 times 1 dose of every day, and 30d is 1 course of treatment.
Criterion of therapeutical effect
Cure: right side side of body flank pain radiation and shoulder back, uncomfortable in chest, distension and fullness in the abdomen is felt sick, bitter taste, transference cures such as yellowish or reddish urine, routine blood test is normal, B ultrasonic: gallbladder wall is normal, and is no crude, and calculus is discharged in the gallbladder, or discharges 75% before the treatment; Glutamate pyruvate transaminase, icteric index are all normal; Appetite increases, and is in high spirits.Take a turn for the better: right side side of body flank pain is pulled and is takeed on the back, distension and fullness in the abdomen, and bitter taste, symptoms such as yellowish or reddish urine obviously alleviate, and calculus is discharged 25-45% before the treatment, and glutamate pyruvate transaminase, icteric index reduce to 70% before the treatment.Invalid: right side side of body flank pain is pulled and is takeed on the back, and distension and fullness in the abdomen is felt sick, and poor appetite is weak, bitter taste, and symptoms such as yellow urine do not have improvement.
Therapeutic outcome: this group patient 30 examples, cure 22 examples, 7 examples that take a turn for the better, invalid 1 example, total effective rate 93%.The 30d that the course of treatment is the shortest, the longest 90d, average 50d.

Claims (10)

1, a kind of Chinese medicine preparation for the treatment of cholelithiasis is characterized in that, the ratio of weight and number of various components is: 10～20 parts of Fructus Aurantiis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Lysimachiaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Evodiaes, 10～20 parts in Natrii Sulfas, 10～20 parts of HUOXUEDAN, 10～20 parts of Endothelium Corneum Gigeriae Galli, 10～20 parts of Spica Prunellaes, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Radix Clematidis, 10～20 parts of Fructus Crataegis, 10～20 parts of Herba Scutellariae Barbataes, 10～20 parts of Spora Lygodii, 10～20 parts in Rhizoma Curcumae Longae, 10～20 parts in Poria.
2, Chinese medicine preparation according to the described treatment cholelithiasis of claim 1 is characterized in that, the ratio of weight and number of various components is: 10～15 parts of Fructus Aurantiis, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Herba Lysimachiaes, 10～15 parts of Radix Curcumaes, 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Evodiaes, 10～15 parts in Natrii Sulfas, 10～15 parts of HUOXUEDAN, 10～20 parts of Endothelium Corneum Gigeriae Galli, 10～20 parts of Spica Prunellaes, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Artemisiae Scopariaes, 10～20 parts of Fructus Toosendans, 10～20 parts of Radix Clematidis, 10～20 parts of Fructus Crataegis, 10～20 parts of Herba Scutellariae Barbataes, 10～20 parts of Spora Lygodii, 10～20 parts in Rhizoma Curcumae Longae, 10～20 parts in Poria.
3, Chinese medicine preparation according to the described treatment cholelithiasis of claim 1 is characterized in that, the ratio of weight and number of various components is: 10～20 parts of Fructus Aurantiis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Lysimachiaes, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Bupleuri, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Evodiaes, 10～20 parts in Natrii Sulfas, 10～20 parts of HUOXUEDAN, 10～15 parts of Endothelium Corneum Gigeriae Galli, 10～15 parts of Spica Prunellaes, 10～15 parts of Radix Scutellariaes, 10～15 parts of Herba Artemisiae Scopariaes, 10～15 parts of Fructus Toosendans, 10～15 parts of Radix Clematidis, 10～15 parts of Fructus Crataegis, 10～15 parts of Herba Scutellariae Barbataes, 10～15 parts of Spora Lygodii, 10～15 parts in Rhizoma Curcumae Longae, 10～15 parts in Poria.
4, Chinese medicine preparation according to the described treatment cholelithiasis of claim 1 is characterized in that, the ratio of weight and number of various components is: 15～20 parts of Fructus Aurantiis, 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Herba Lysimachiaes, 15～20 parts of Radix Curcumaes, 15～20 parts of Radix Bupleuri, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts of the Radix Paeoniae Albas, 15～20 parts of Fructus Evodiaes, 15～20 parts in Natrii Sulfas, 15～20 parts of HUOXUEDAN, 15～20 parts of Endothelium Corneum Gigeriae Galli, 15～20 parts of Spica Prunellaes, 15～20 parts of Radix Scutellariaes, 15～20 parts of Herba Artemisiae Scopariaes, 15～20 parts of Fructus Toosendans, 15～20 parts of Radix Clematidis, 15～20 parts of Fructus Crataegis, 15～20 parts of Herba Scutellariae Barbataes, 15～20 parts of Spora Lygodii, 15～20 parts in Rhizoma Curcumae Longae, 15～20 parts in Poria.
According to the Chinese medicine preparation of each described treatment cholelithiasis in the claim 1～4, it is characterized in that 5, described Chinese medicine preparation is fried in shallow oil decoction in use and taken, 1 dose of every day, decocting is obeyed at twice, and per 30 days is a course of treatment.
6, according to the Chinese medicine preparation of each described treatment cholelithiasis in the claim 1～4, it is characterized in that the dosage form of described Chinese medicine preparation is: honey refining pill, hydration pill, capsule, tablet, drop pill, syrup, powder, slow releasing pharmaceutical, controlled release drug, oral liquid medicine, gel, soft extract, extractum or membrane.
7, a kind ofly it is characterized in that as the preparation method of the Chinese medicine preparation of treatment cholelithiasis as described in each in the claim 1～6 dosage form of described Chinese medicine preparation is a capsule, its preparation method may further comprise the steps:
A. described component is pulverized the back and add ethanol, heating and refluxing extraction 3 times;
B. 3 extracting solution are merged, reclaim ethanol, concentrate sucking filtration after adsorption resin column absorption;
C. with deionized water or distilled water eluting, the reuse ethanol elution is collected ethanol elution, removes alcohol solvent, obtains component medicated powder, incapsulates and is made as capsule after adsorbing.
According to the described preparation method of claim 7, it is characterized in that 8, among the described step a, described component is pulverized the back add 10 times of amount ethanol, heating and refluxing extraction 3 times is heated to be 2 hours at every turn.
9, according to the described preparation method of claim 7, it is characterized in that, among the described step b, after 3 extracting solution merging, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, when the relative density of filtrate is 20 ℃ 1.08, described filtrate flow is the adsorption resin column absorption of 10L through volume.
10, according to the described preparation method of claim 7, it is characterized in that, among the described step c, after the absorption with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule.
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