CN108014238A - It is a kind of to treat fracture, pharmaceutical composition of bone split and preparation method thereof - Google Patents
It is a kind of to treat fracture, pharmaceutical composition of bone split and preparation method thereof Download PDFInfo
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- CN108014238A CN108014238A CN201711332441.1A CN201711332441A CN108014238A CN 108014238 A CN108014238 A CN 108014238A CN 201711332441 A CN201711332441 A CN 201711332441A CN 108014238 A CN108014238 A CN 108014238A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
Fracture, the pharmaceutical composition of bone split are treated the present invention provides a kind of, it is prepared by the bulk pharmaceutical chemicals of following weight proportioning：32 48 parts of dragon's blood, 25 37 parts of frankincense, 25 37 parts of myrrh, 16 25 parts of ramulus mori, 16 25 parts of Ligusticum wallichii, 16 25 parts of Chinese ephedra, 16 25 parts of teasel root, 8 12 parts of folium artemisiae argyi, 8 13 parts of native copper.Present invention also offers the preparation method and purposes of said composition.Composition provided by the invention, compatibility is reasonable, and each flavour of a drug complement each other, and have no toxic side effect, and has good therapeutic effect to fracture, bone split, has stronger actual application value.
Description
Technical field
Fracture, pharmaceutical composition of bone split and its preparation method and application are treated the present invention relates to a kind of.
Background technology
Fracture, bone split are that the integrality of bone or continuity occur complete or partial property and interrupt, and are mainly shown as swelling, pain
Bitterly, deformity, limitation of activity, local tenderness.Fracture, bone split can be caused by wounds and skeletal diseases, the latter such as osteomyelitis, bone tumour
Caused destruction of bone, bone is occurred by slight external force and is interrupted.For a kind of common frequently-occurring disease in clinic.Due to traffic accident, build
Build unexpected and irresistible natural calamity to occur, be gradually increasing this disease incidence, seriously affected people's health life,
And perform a surgical operation or manual reduction treating after, and increase tissue damage to some extent, the suffering limb stasis of blood is swollen exacerbation, pain adds
It is acute.How accelerating union of bone fracture is one of key subjects that current medical field is paid close attention to jointly.
At present, doctor trained in Western medicine is typically that have an operation upper clamp plate, gypsum is fixed, has an injection for fracture, the therapeutic scheme taken of bone split
Hang water, rest quiet at home to recover oneself, it has the drawback that：Bone healing time is grown, and takes 2-4 months at the soonest, and is come for the elderly
Say, healing time is longer；It is big to channels and collaterals, ligament injury, maimed person may be caused；Medical expense is high；Some situations can not treat.
In contrast, advantage is had more using TCM Therapy, Chinese traditional treatment fracture, bone injury have thousands of years of history, product
Rich experiences are tired out, the advantage in terms of union is promoted increasingly shows.Traditional Chinese medicine thinks that qi and blood is the material of physical activity
Basis.《Plain Questions menstruation regulating opinion》Say：" owner of people, blood and gas ear ".《It is difficult difficult through 22》Say：" qi warming body, blood master are moistened
It." gas has warm use, blood, which has, moistens foster function, four limbs bones of the body collectively, the vital organs of the human body, all relies qi and blood foster to moisten.Bone is human body
Important component.Certainly also it be unable to do without supplementing nutrition for qi and blood.《A Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates pieces》Say：" part of the body cavity above the diaphragm housing the heart and lungs outlet, the nourishing the bone with warm boundary between muscles
Section ".《This Tibetan of Ling Shu Miraculous Pivot or Divine Axis piece》Add：" passages through which vital energy circulates person, so qi and blood circulation promotion and Rong Yinyang, moisten muscles and bones, sharp joint person ".Illustrate gas
Blood is the important substance of bone of supplementing nutrition.Passages through which vital energy circulates is unimpeded, and qi and blood reconciles, and bone supplements nutrition with regard to that can obtain and makes powerful muscle and bone.Accordingly can be with
Think：After fracture, it is necessary to which passages through which vital energy circulates is unimpeded, and qi and blood, which reconciles, to heal.If qi depression to blood stasis, passages through which vital energy circulates is inaccessible, then derangement of Qi and blood,
The broken ends of fractured bone cannot nourish, and just be difficult to heal.《General Records of Holy Universal Relief traumatics fracture door》Cloud：" people all over the body, defend by blood Ying Qi, and circulation is infinite, or
Muscles joint, causes to be traumaticd fracture, then qi and blood stasis pain, must not hinder, and must not roll over and continues by mistake "." arteries and veins person's house of blood, blood arteries and veins
In, pass through and managed in meat, ring Zhou Yishen, because solid outside its human body, leads in passages through which vital energy circulates, be can streamer not lose its normal.If because traumatiing fracture, interior dynamic warp
Network, the road of blood, must not declare it is logical, siltation do not dissipate, for swell be pain, control preferably removes evil silt, make qi and blood circulation, then can answer.It is old
Scholar's tongued bell《The dialectical record of all kinds of diseases and ailments》Say：" blood not reviver become silted up do not go, silt do not go then bone cannot connect.”
Qi and blood is the important substance of bone of supplementing nutrition.After fracture, as qi and blood is vigorous, with regard to broken ends of fractured bone connection can be accelerated；Instead
It, such as insufficiency of vital energy and blood, fractures with regard to refractory conjunction.
《Plain Questions declares a five gas pieces》Say：" Shen controls bone "；《The big opinion of YIN YANG classification of natural phenomena》Say：" kidney producing bone marrow "；《Six sections are hidden as opinion》
Also say：" kidney person ... it fills in bone ".The vital essence of kidney is prompted, bone can be given birth to and brought up.The vigorous then bone growth of kidney qi, kidney qi decline
Then bone also fails therewith.
Therefore, the abundant theoretical foundation accumulated for a long time according to the traditional Chinese medical science, precisely diagnosis and treatment, formula, is developed to bone
Folding, bone split therapeutic effect are good, few side effects, lower-cost Chinese medicine composition, significant to patient with bone fracture.
The content of the invention
It is an object of the invention to provide a kind of cost it is low, to fracture, the good pharmaceutical composition of bone split therapeutic effect and its
Preparation method and purposes.
Fracture, the pharmaceutical composition of bone split are treated the present invention provides a kind of, it is the bulk pharmaceutical chemicals matched by following weight
It is prepared：
32-48 parts of dragon's blood, 25-37 parts of frankincense, 25-37 parts of myrrh, 16-25 parts of ramulus mori, 16-25 parts of Ligusticum wallichii, Chinese ephedra 16-25
Part, 16-25 parts of teasel root, 8-12 parts of folium artemisiae argyi, 8-13 parts of native copper.
Wherein, it is prepared by the raw material of following weight proportioning：34-44 parts of dragon's blood, 27-33 parts of frankincense, myrrh 27-
33 parts, 18-22 parts of ramulus mori, 18-22 parts of Ligusticum wallichii, 18-22 parts of Chinese ephedra, 18-22 parts of teasel root, 9-11 parts of folium artemisiae argyi, 9-11 parts of native copper.
Wherein, it is prepared by the raw material of following weight proportioning：40 parts of dragon's blood, 30 parts of frankincense, 30 parts of myrrh, ramulus mori
20 parts, 20 parts of Ligusticum wallichii, 20 parts of Chinese ephedra, 20 parts of teasel root, 10 parts of folium artemisiae argyi, 10 parts of native copper.
Wherein, the composition is with dragon's blood, frankincense, myrrh, ramulus mori, Ligusticum wallichii, Chinese ephedra, teasel root, folium artemisiae argyi and native copper
Medicinal powder, or water or extractive with organic solvent are active ingredient, add pharmaceutically acceptable auxiliary material or is prepared by complementary component
The preparation formed.
Pharmaceutically acceptable auxiliary material of the present invention, refers to the material being included in addition to the active ingredient (s in formulation, bag
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifying agent includes Tween-80, aliphatic acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary component, it has certain physiological activity, but the addition of the component will not change
Become the leading position of above-claimed cpd or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work(
Effect is only the utilization to the component known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral formulations.
Wherein, the oral formulations are decoction, paste, oral liquid, granule, capsule, pill, tablet, powder.
Present invention also offers the preparation method of above-mentioned composition, it includes the following steps：
A, the raw material of each weight proportion is weighed；
Bulk pharmaceutical chemicals are directly beaten to powder, or after adding water or organic solvent extraction, add pharmaceutically acceptable auxiliary material or auxiliary b,
Helping property component is prepared.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition occupation mode, after water carries, since the soluble end of water is wide, and energy
Enough by most of active ingredient dissolution, make medicine be easier to be absorbed by the body, work faster, such as the form of medication such as decoction；With
Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of active ingredient in vivo in medicinal material, but medicinal material is un-extracted,
Active ingredient still needs to the re-absorption of dissolution in vivo, its opposite water extract that works is slower, but also weakens and be harmful into medicinal material at the same time
Divide the toxicity caused by human body, be suitable for long-term use, original powder is such as prepared into pill form of medication.At present in pharmacy
During, ethanol extracts medicine as solvent, and one of most commonly seen extracting mode, and ethanol is molten for semi-polarity
Agent, solubility property circle can dissolve water miscible some components between polarity and nonpolar solvent, can also dissolve nonpolar molten
Some components of agent dissolving, usually replace decocting with ethanol extraction, so as to avoid the dissolution of a large amount of invalid components, raising effectively into
The concentration and extraction efficiency divided, but the price of ethanol is expensive compared with water, in the big production of modern pharmaceutical industry, is produced into save
This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to
Various productions and demand when using, can optionally water carries, original powder, alcohol extracting or combinations thereof method prepare specific agent
Type.
Wherein, specific preparation method is as follows：
Tablet：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or it is complementary into
Point, granulation, whole grain, tabletting, to obtain the final product；
Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；
Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；
Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or auxiliary
Helping property component, mixes, granulation, whole grain, drying, to obtain the final product；
Capsule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, and adds auxiliary material or auxiliary
Property component, mix, it is encapsulated, to obtain the final product；
The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；
Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；
Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting,
Instill in not miscible condensate liquid and condense, to obtain the final product.
The organic solvent is the ethanol of various concentrations, such as the ethanol of 25%-95%.
Present invention also offers purposes of the above-mentioned composition in the medicine for the treatment of fracture and/or bone split is prepared.
The present inventor has found in treatment clinical course for many years, and with the increase at age, treating bone diseases can be more and more.
The a variety of bone class diseases such as origin cause of formation such as osteoporosis, spur, waist dish outstanding, cervical spondylosis is due to that main body sclerotin variation causes more
's.Namely so-called retrogression pathological changes.Draw an analogy, the bone of people is compared to house, with the increase of service life, house meeting
(osteoporosis) more and more built on the sand, when house becomes dilapidated house, it is necessary to some stents are taken to ensure that house will not collapse, and
Waist dish outstanding, spur etc. are exactly human body itself to avoid the stent that " dilapidated house collapses " is come into being.And the medicine of synthetism is exactly
To proceed blood cycle, benefiting kidney-essence be means to achieve the purpose that to allow knochenbruch to grow rapidly, the strong main body sclerotin of such treatment,
And just because of this, also so that many sclerotin class disease such as waist dish outstanding, spur, osteoporosises etc. are better or even health
It is multiple.
In pharmaceutical composition of the present invention, using dragon's blood as monarch drug in a prescription, scattered stasis pain, hemostasia and promoting granulation；Frankincense, myrrh are ministerial drug, living
Blood myogenic, swelling and pain relieving, are helped with ramulus mori, Ligusticum wallichii, clearing and activating the channels and collaterals, blood-activating and qi-promoting, using Chinese ephedra, teasel root, folium artemisiae argyi, native copper to make medicine
Coordinating the drug actions of a prescription, pharmaceutical composition compatibility of the present invention is reasonable, and each flavour of a drug complement each other, and each taste Chinese medicine is according to dosage provided by the invention
After matching compatibility, it can cooperate with and have the function that quickly treatment fracture and bone split, can significantly alleviate pain caused by fracture bone split,
Clinical cure rate is high；It is easy to use and present composition security is good, has no toxic side effect, provided for clinic a kind of new
Medicament selection.
Obviously, the above according to the present invention, according to the ordinary technical knowledge and customary means of this area, is not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, remakes further specifically the above of the present invention
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
It is described further below with embodiment, but the present invention is not limited to these embodiments.
The preparation of 1 medicinal tablet of the present invention of embodiment
Take dragon's blood 40g, frankincense 30g, myrrh 30g, ramulus mori 20g, Ligusticum wallichii 20g, Chinese ephedra 20g, teasel root 20g, folium artemisiae argyi 10g, from
Right copper 10g, beats powder, direct powder compression, up to tablet.
The preparation of 2 medicinal tablet of the present invention of embodiment
Take dragon's blood 34g, frankincense 27g, myrrh 27g, ramulus mori 18g, Ligusticum wallichii 18g, Chinese ephedra 22g, teasel root 22g, folium artemisiae argyi 11g, from
Right copper 11g, adds water to cook extraction, is condensed into medicinal extract, starch granulation, whole grain, tabletting is added, up to tablet.
The preparation of 3 medicine capsule of the present invention of embodiment
Take dragon's blood 44g, frankincense 33g, myrrh 33g, ramulus mori 22g, Ligusticum wallichii 22g, Chinese ephedra 18g, teasel root 18g, folium artemisiae argyi 9g, nature
Copper 9g, adds water to cook extraction, is condensed into medicinal extract, adds auxiliary material, mixes, packing, up to capsule.
The preparation of the medicine water-bindered pill of the present invention of embodiment 4
Take dragon's blood 32g, frankincense 25g, myrrh 25g, ramulus mori 25g, Ligusticum wallichii 25g, Chinese ephedra 25g, teasel root 25g, folium artemisiae argyi 12g, from
Right copper 13g, beats powder, sieves, and adds excipient, water pill is dry, up to the water-bindered pill.
The preparation of the medicine honeyed bolus of the present invention of embodiment 5
Take dragon's blood 48g, frankincense 37g, myrrh 37g, ramulus mori 16g, Ligusticum wallichii 16g, Chinese ephedra 16g, teasel root 16g, folium artemisiae argyi 8g, nature
Copper 8g, beats powder, sieving, adds honey, pill is dry, up to honeyed bolus.
The preparation of the medicine decoction of the present invention of embodiment 6
Take dragon's blood 40g, frankincense 30g, myrrh 30g, ramulus mori 20g, Ligusticum wallichii 20g, Chinese ephedra 20g, teasel root 20g, folium artemisiae argyi 10g, from
Right copper 10g, soaks decoction, merging filtrate, filtering, up to decoction.
The preparation of 7 medicinal tablet of the present invention of embodiment
Take dragon's blood 38g, frankincense 30g, myrrh 32g, ramulus mori 25g, Ligusticum wallichii 16g, Chinese ephedra 20g, teasel root 25g, folium artemisiae argyi 12g, from
Right copper 10g, is extracted with ethanol, obtains ethanol extract, is condensed into medicinal extract, starch granulation, whole grain, tabletting is added, up to tablet.
The preparation of 8 medicine oral liquid of the present invention of embodiment
Take dragon's blood 40g, frankincense 28g, myrrh 27g, ramulus mori 20g, Ligusticum wallichii 20g, Chinese ephedra 18g, teasel root 19g, folium artemisiae argyi 10g, from
Right copper 8g, soaks decoction, merging filtrate, concentration, embedding, sterilizing, up to oral liquid.
Illustrate beneficial effects of the present invention with the mode of test example below：
The clinical efficacy of 1 medicine composite for curing of the present invention of test example fracture
1 experiment material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 42, and the age is 51 years old average.
2 experimental methods
2.1 include case standard：1. it is diagnosed as the patient of fracture.2. it is diagnosed as the patient of bone split.
2.2 Excluded cases standards：1. pregnant woman, those who are allergic to this drug.2. it is associated with angiocarpy, liver, kidney and hemopoietic system etc.
Severe primary disease, mental patient.3. all do not meet inclusive criteria, not by regulation medication, curative effect or data can not be judged
It is not congruent to affect the treatment or security judgement person.
2.3 curative effects judge
Cure：Joint structure is normal, and symptom disappears, and function is wholly or substantially recovered.
Improve：Joint structure is normal, and symptom improves, and funtion part is limited.
It is not cured：Dislocation does not reset, and symptom is without improvement, dysfunction.
2.4 medication
Daily 3 times, early, middle and late once a dose, each taking when need to separate more than half an hour with the meal time,
Each taking medicine equivalent to 3 grams crude drugs of weight, and need to be taken with yellow rice wine or red wine, to help the efficacy of a drug.
3 experimental results
The experiment results show that 1 month visible positive effect is taken, and pharmaceutical composition of the present invention, total effective rate 100%, this
Invention pharmaceutical composition has fracture, bone split good therapeutic effect, and clinical cure rate is high.
2 medicine composite for curing of the present invention of test example fracture, the model case of bone split
XX is opened, female 82 years old, fracture is built in thick honor, after the hospital surgical of Dongzhimen, is informed by hospital because osteoporosis phenomenon is tight
Weight, therefore need at least more than 100 days sides to heal, takes more than 40 days after this medicine and feels substantially without sense of discomfort, it is desirable to household with
It goes to hospital to make film, and film making finds that fracture heals completely.
To sum up, present composition compatibility is reasonable, has good therapeutic effect to fracture, bone split, can significantly alleviate bone
Pain caused by bone split is rolled over, clinical cure rate is high, and present composition security is good, has no toxic side effect, easy to use, faces
Bed application prospect is good.
Claims (9)
1. a kind of treat fracture, the pharmaceutical composition of bone split, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportioning
Form：
32-48 parts of dragon's blood, 25-37 parts of frankincense, 25-37 parts of myrrh, 16-25 parts of ramulus mori, 16-25 parts of Ligusticum wallichii, 16-25 parts of Chinese ephedra,
16-25 parts of teasel root, 8-12 parts of folium artemisiae argyi, 8-13 parts of native copper.
2. pharmaceutical composition according to claim 1, it is characterised in that：It is by following weight proportioning raw material prepare and
Into：
34-44 parts of dragon's blood, 27-33 parts of frankincense, 27-33 parts of myrrh, 18-22 parts of ramulus mori, 18-22 parts of Ligusticum wallichii, 18-22 parts of Chinese ephedra,
18-22 parts of teasel root, 9-11 parts of folium artemisiae argyi, 9-11 parts of native copper.
3. pharmaceutical composition according to claim 2, it is characterised in that：It is by following weight proportioning raw material prepare and
Into：
40 parts of dragon's blood, 30 parts of frankincense, 30 parts of myrrh, 20 parts of ramulus mori, 20 parts of Ligusticum wallichii, 20 parts of Chinese ephedra, 20 parts of teasel root, 10 parts of folium artemisiae argyi,
10 parts of native copper.
4. according to the composition described in claim 1-3 any one, it is characterised in that：The composition be with dragon's blood, frankincense,
Myrrh, ramulus mori, Ligusticum wallichii, Chinese ephedra, teasel root, the medicinal powder of folium artemisiae argyi and native copper, or water or extractive with organic solvent are active ingredient,
Add the preparation that pharmaceutically acceptable auxiliary material or complementary component are prepared.
5. composition according to claim 4, it is characterised in that：The preparation is oral formulations.
6. composition according to claim 5, it is characterised in that：The oral formulations for decoction, paste, oral liquid,
Granula, capsule, pill, tablet, powder.
7. the preparation method of the composition described in claim 1-6 any one, it is characterised in that：It includes the following steps：
A, the raw material of each weight proportion is weighed；
Bulk pharmaceutical chemicals are directly beaten to powder, or after adding water or organic solvent extraction, add pharmaceutically acceptable auxiliary material or complementary b,
Component is prepared.
8. preparation method according to claim 7, it is characterised in that：Specific preparation method is as follows：
Tablet：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or complementary component, system
Grain, whole grain, tabletting, to obtain the final product；
Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；
Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；
Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or complementary
Component, mixes, granulation, whole grain, drying, to obtain the final product；
Capsule：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, add auxiliary material or it is complementary into
Point, mix, it is encapsulated, to obtain the final product；
The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；
Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；
Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, instill
Condensed in not miscible condensate liquid, to obtain the final product.
9. purposes of the composition in the medicine for the treatment of fracture and/or bone split is prepared described in claim 1-6 any one.
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| CN201711332441.1A CN108014238A (en) | 2017-12-13 | 2017-12-13 | It is a kind of to treat fracture, pharmaceutical composition of bone split and preparation method thereof |
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| CN1650968A (en) * | 2004-12-08 | 2005-08-10 | 崔彬 | Medicinal preparation for treating bone damage disease and its preparation method |
| CN101357195A (en) * | 2007-08-03 | 2009-02-04 | 陈红 | Ancestral secret prescriptions for mainly treating bone knitting, injuries from falls and preparation technique thereof |
| CN103830471A (en) * | 2012-11-21 | 2014-06-04 | 李玉明 | Prescription of orally taken traditional Chinese medicine for bonesetting |
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2017
- 2017-12-13 CN CN201711332441.1A patent/CN108014238A/en active Pending
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|---|---|---|---|---|
| CN1650968A (en) * | 2004-12-08 | 2005-08-10 | 崔彬 | Medicinal preparation for treating bone damage disease and its preparation method |
| CN101357195A (en) * | 2007-08-03 | 2009-02-04 | 陈红 | Ancestral secret prescriptions for mainly treating bone knitting, injuries from falls and preparation technique thereof |
| CN103830471A (en) * | 2012-11-21 | 2014-06-04 | 李玉明 | Prescription of orally taken traditional Chinese medicine for bonesetting |
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