CN108014235A - It is a kind of to treat fracture or the pharmaceutical composition of bone split and its preparation method and application - Google Patents

It is a kind of to treat fracture or the pharmaceutical composition of bone split and its preparation method and application Download PDF

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CN108014235A
CN108014235A CN201711329519.4A CN201711329519A CN108014235A CN 108014235 A CN108014235 A CN 108014235A CN 201711329519 A CN201711329519 A CN 201711329519A CN 108014235 A CN108014235 A CN 108014235A
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parts
preparation
pharmaceutical composition
pharmaceutical chemicals
bulk pharmaceutical
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郭博信
黄云
沈晓洲
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Traditional Chinese Medicine Science And Technology (beijing) Ltd By Share Ltd Bosin
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Traditional Chinese Medicine Science And Technology (beijing) Ltd By Share Ltd Bosin
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses a kind of pharmaceutical composition, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：30 50 parts of frankincense, 25 55 parts of myrrh, 28 50 parts of dragon's blood, 20 50 parts of teasel root, 18 42 parts of safflower, 20 40 parts of notopterygium root, 22 40 parts of levisticum, 12 38 parts of Chinese ephedra, 6 15 parts of native copper.Present invention also offers the preparation method and purposes of the pharmaceutical composition.Pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, and has no adverse reaction, the feeling of pain caused by fracture, bone split can be alleviated rapidly, accelerate patient and get well, significantly shorten the healing time of fracture or bone split, fracture or bone split can be effectively treated, there is stronger actual application value.

Description

It is a kind of to treat fracture or the pharmaceutical composition of bone split and its preparation method and application
Technical field
Fracture or the pharmaceutical composition of bone split are treated the present invention relates to a kind of.
Background technology
Fracture is that the continuity of bone structure is broken completely or partially.Be more common in children and the elderly, young people also when There is generation.Patient is often-a position fracture, and minority is multiple fracture.Through appropriate processing in time, most patients can recover former The function of coming, a few patients can leave different degrees of sequelae.
At present clinically for fracture based on operative treatment, by open reset or internal fixation with steel plate pair is used Fracture portions are treated.However, operative treatment fracture but faces the drawbacks such as high cost, wound are big, complication is more, for example, Operation can damage periosteum and surrounding soft tissue, influence local blood and supply, extension healing time, and metal inside-fixture Can occur rejection, and it is possible that postoperative unknown cause hyperpyrexia, the enhancing of fracture periosteal reaction, occur nail trace, Bone ischemic, bone information and poroma delay the complication such as moulding, and the prognosis to patient causes harmful effect.
Orthopedics of Chinese Medicine developing history it is long, show according to clinical research, traditional Chinese medical science conservative treatment can effectively treat fracture, There is the characteristics of spending less, wound is small, good prognosis compared to operative treatment, be not only able to the recovery of promotion patient health also significantly The time for shortening union.Chen little Jun, " limbs fracture tcm characteristic therapeutic effect ", Clinical Journal of Chinese Medicine, the 18th phase in 2012 disclose oral Thyroid Nodules (radix astragali 30g, Radix Salviae Miltiorrhizae 20g, HERBA EPIMEDII 20g, Ligusticum wallichii 20g, dipsacus root 20g, Angelica sinensis 15g, Fructus Corni 15g, calcined Dragon's bone 15g, cultivated land 15g, Chinese yam 15g, safflower 20g, the radix paeoniae rubrathe 12g, Semen Cuscutae 12g, rhizome of davallia 12g, cortex albiziae 12g, radix glycyrrhizae 6g), and coordinate manipulative reduction, plintlet to fix and the external application of Chinese medicine Fracture can effectively be treated.Application number：96103489.0 denomination of invention：A kind of medicine for treating fracture and long bone patch, it mainly with Notopterygium root, levisticum, frankincense, myrrh, the rhizome of davallia, pyritum ignited, orange peel, dragon's blood, Soil unit are prepared, which is externally applied drug, By the way that bulk pharmaceutical chemicals are pulverized, stir evenly and spread on affected part, fracture can be treated.
Now have no to coordinate in frankincense, myrrh, dragon's blood, teasel root, safflower, notopterygium root, levisticum, Chinese ephedra and native copper and be used to treat bone Folding or the report of bone split.
The content of the invention
Fracture or the pharmaceutical composition of bone split are treated the present invention provides a kind of, and its preparation method and application.
The present invention provides a kind of pharmaceutical composition, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning： 30-50 parts of frankincense, 25-55 parts of myrrh, 28-50 parts of dragon's blood, 20-50 parts of teasel root, 18-42 parts of safflower, 20-40 parts of notopterygium root, levisticum 22-40 parts, 12-38 parts of Chinese ephedra, 6-15 parts of native copper.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：35-45 parts of frankincense, myrrh 30-50 Part, 32-48 parts of dragon's blood, 24-46 parts of teasel root, 20-40 parts of safflower, 22-38 parts of notopterygium root, 24-38 parts of levisticum, 15-25 parts of Chinese ephedra, from Right 8-12 parts of copper.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：40 parts of frankincense, 40 parts of myrrh, dragon's blood 40 parts, 30 parts of teasel root, 30 parts of safflower, 30 parts of notopterygium root, 30 parts of levisticum, 20 parts of Chinese ephedra, 10 parts of native copper.
Wherein, the composition is with frankincense, myrrh, dragon's blood, teasel root, safflower, notopterygium root, levisticum, Chinese ephedra and native copper Medicinal powder, or water or extractive with organic solvent are active ingredient, are prepared into plus pharmaceutically acceptable auxiliary material and pharmaceutically commonly use Preparation.
Pharmaceutically acceptable auxiliary material of the present invention, refers to the material being included in addition to the active ingredient (s in formulation, bag Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite, Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes 0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifying agent includes Tween-80, aliphatic acid sorb Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary component, it has certain physiological activity, but the addition of the component will not change Become the leading position of above-claimed cpd or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work( Effect is only the utilization to the component known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral formulations.
Wherein, the preparation is powder, decoction, granule, tablet, capsule, oral liquid, pill.
The present invention also extracts the preparation method of foregoing pharmaceutical composition, it is comprised the following steps：
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration, adds Pharmaceutically acceptable auxiliary material or complementary component are prepared into pharmaceutically common preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition occupation mode, after water carries, since the soluble end of water is wide, and energy Enough by most of active ingredient dissolution, make medicine be easier to be absorbed by the body, work faster, such as the form of medication such as decoction；With Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of active ingredient in vivo in medicinal material, but medicinal material is un-extracted, Active ingredient still needs to the re-absorption of dissolution in vivo, its opposite water extract that works is slower, but also weakens and be harmful into medicinal material at the same time Divide the toxicity caused by human body, be suitable for long-term use, original powder is such as prepared into pill form of medication.At present in pharmacy During, ethanol extracts medicine as solvent, and one of most commonly seen extracting mode, and ethanol is molten for semi-polarity Agent, solubility property circle can dissolve water miscible some components between polarity and nonpolar solvent, can also dissolve nonpolar molten Some components of agent dissolving, usually replace decocting with ethanol extraction, so as to avoid the dissolution of a large amount of invalid components, raising effectively into The concentration and extraction efficiency divided, but the price of ethanol is expensive compared with water, in the big production of modern pharmaceutical industry, is produced into save This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to Various productions and demand when using, can optionally water carries, original powder, alcohol extracting or combinations thereof method prepare specific agent Type.
Wherein, specific preparation method is as follows：
Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；
Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；
Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or auxiliary Helping property component, mixes, granulation, whole grain, drying, to obtain the final product；
Tablet：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or it is complementary into Point, granulation, whole grain, tabletting, to obtain the final product；
Capsule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, and adds auxiliary material or auxiliary Property component, mix, it is encapsulated, to obtain the final product；
The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；
Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；
Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, Instill in not miscible condensate liquid and condense, to obtain the final product.
The organic solvent is the ethanol of various concentrations, such as the ethanol of 25%-95%.
The present invention finally provides purposes of the foregoing pharmaceutical composition in the medicine for the treatment of fracture or bone split is prepared.
Ancient Times in China ancient books and records have description to the treatment after fracture and prognosis.《Plain Questions menstruation regulating opinion》Cloud：" owner of people, Blood and gas ear ".《It is difficult difficult through 22》Cloud：" qi warming body, blood nourishing.”《A Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates pieces》Cloud：" part of the body cavity above the diaphragm housing the heart and lungs outlet, with Warm boundary between muscles and nourishing the bone section ".《This Tibetan of Ling Shu Miraculous Pivot or Divine Axis piece》Cloud：" passages through which vital energy circulates person, so qi and blood circulation promotion and Rong Yinyang, moisten muscles and bones, sharp joint person ".Above ancient books describes out the material base that qi and blood is physical activity, and bone be unable to do without supplementing nutrition for qi and blood；When passages through which vital energy circulates is unimpeded, gas Blood reconciles, and bone supplements nutrition with regard to that can obtain and makes powerful muscle and bone.《General Records of Holy Universal Relief traumatics fracture door》Cloud：" people all over the body, defend by blood Ying Qi, circulates It is infinite, or muscles joint, cause to be traumaticd fracture by mistake, then qi and blood stasis pain, must not hinder, and must not roll over and continues "." arteries and veins person's house of blood, In blood arteries and veins, pass through and managed in meat, ring Zhou Yishen, because solid outside its human body, leads in passages through which vital energy circulates, be can streamer not lose its normal.It is if interior because traumatiing fracture Dynamic channels and collaterals, the road of blood must not declare logical, and siltation does not dissipate, and is pain to swell, and controls and preferably removes evil silt, makes qi and blood circulation, then can be complete again ." Chen Shiduo《The dialectical record of all kinds of diseases and ailments》Cloud：" blood not reviver become silted up do not go, silt do not go then bone cannot connect." it can be seen from the above, fracture After, it is necessary to passages through which vital energy circulates is unimpeded, and qi and blood, which reconciles, to heal；If qi depression to blood stasis, passages through which vital energy circulates occlusion, then derangement of Qi and blood, the broken ends of fractured bone obtain not To nourishing, just it is difficult to heal.In addition,《Plain Questions declares a five gas pieces》Cloud：" Shen controls bone "；《The big opinion of YIN YANG classification of natural phenomena》Cloud：" kidney gives birth to bone Marrow "；《Six sections are hidden as opinion》Also say：" kidney person, it is filled in bone ".The vital essence of kidney is explicitly pointed out, bone can be given birth to and brought up.Kidney qi is vigorous then Bone growth, then bone also fails therewith for kidney qi decline.
It is considered herein that fracture or the interpretation of the cause, onset and process of an illness of bone split are deficiency of kidney-QI, vim and vigour are got along well, and muscles and bones is weak；To proceed blood cycle, mend Kidney-nourishing essence is treatment fracture or the mechanism of bone split, can nourish kidney qi, the regulation of qi and blood, to achieve the purpose that to give birth to and bring up bone, so as to have Effect treatment fracture or bone split.
In pharmaceutical composition of the present invention, frankincense, myrrh, dragon's blood are monarch drug in a prescription, and blood-activating and qi-promoting analgesic, removing blood stasis and hemostasis, subsides a swelling and give birth to Flesh；Teasel root, safflower, notopterygium root are ministerial drug, promoting blood circulation and removing blood stasis, reunion of fractured tendons and bones；Assistant is with levisticum, Chinese ephedra dispelling wind and eliminating dampness, arthritis analgesic；Borrow again The effect of native copper synthetism acts on affected part.
Pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, and has no adverse reaction, can alleviate rapidly because fracture, Feeling of pain caused by bone split, accelerates patient and gets well, significantly shorten the healing time of fracture or bone split, can effectively treat fracture Or bone split, there is stronger actual application value.
Obviously, the above according to the present invention, according to the ordinary technical knowledge and customary means of this area, is not departing from Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, remakes further specifically the above of the present invention It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of 1 medicinal tablet of the present invention of embodiment
Take frankincense 40g, myrrh 40g, dragon's blood 40g, teasel root 30g, safflower 30g, notopterygium root 30g, levisticum 30g, Chinese ephedra 20g, from Right copper 10g, beats powder, direct powder compression, up to tablet.
The preparation of 2 medicinal tablet of the present invention of embodiment
Take frankincense 30g, myrrh 25g, dragon's blood 28g, teasel root 20g, safflower 18g, notopterygium root 20g, levisticum 22g, Chinese ephedra 12g, from Right copper 6g, adds water to cook extraction, is condensed into medicinal extract, starch granulation, whole grain, tabletting is added, up to tablet.
The preparation of 3 medicine capsule of the present invention of embodiment
Take frankincense 50g, myrrh 55g, dragon's blood 50g, teasel root 50g, safflower 42g, notopterygium root 40g, levisticum 40g, Chinese ephedra 38g, from Right copper 15g, adds water to cook extraction, is condensed into medicinal extract, adds auxiliary material, mixes, packing, up to capsule.
The preparation of the medicine water-bindered pill of the present invention of embodiment 4
Take frankincense 35g, myrrh 30g, dragon's blood 32g, teasel root 2
4g, safflower 20g, notopterygium root 22g, levisticum 24g, Chinese ephedra 15g, native copper 8g, beat powder, sieving, add excipient, and water is general Ball, it is dry, up to the water-bindered pill.
The preparation of the medicine honeyed bolus of the present invention of embodiment 5
Take frankincense 45g, myrrh 50g, dragon's blood 48g, teasel root 46g, safflower 40g, notopterygium root 38g, levisticum 38g, Chinese ephedra 25g, from Right copper 12g, beats powder, sieves, and adds honey, pill is dry, up to honeyed bolus.
The preparation of the medicine decoction of the present invention of embodiment 6
Take frankincense 40g, myrrh 40g, dragon's blood 40g, teasel root 30g, safflower 30g, notopterygium root 30g, levisticum 30g, Chinese ephedra 20g, from Right copper 10g, soaks decoction, merging filtrate, filtering, up to decoction.
The preparation of 7 medicinal tablet of the present invention of embodiment
Take frankincense 45g, myrrh 50g, dragon's blood 48g, teasel root 46g, safflower 40g, notopterygium root 38g, levisticum 38g, Chinese ephedra 25g, from Right copper 12g, is extracted with ethanol, obtains ethanol extract, is condensed into medicinal extract, starch granulation, whole grain, tabletting is added, up to tablet.
The preparation of 8 medicine oral liquid of the present invention of embodiment
Take frankincense 50g, myrrh 55g, dragon's blood 50g, teasel root 50g, safflower 42g, notopterygium root 40g, levisticum 40g, Chinese ephedra 38g, from Right copper 15g, soaks decoction, merging filtrate, concentration, embedding, sterilizing, up to oral liquid.
Beneficial effects of the present invention are proved below by way of specific clinical test：
1 medicine composite for curing of the present invention of test example is fractured or the clinical efficacy of bone split
1 experiment material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 45, and the age is 48 years old average.
2 experimental methods
2.1 include case standard：1. it is diagnosed as the patient of fracture.2. it is diagnosed as the patient of bone split.
2.2 Excluded cases standards：1. pregnant woman, those who are allergic to this drug.2. it is associated with angiocarpy, liver, kidney and hemopoietic system etc. Severe primary disease, mental patient.3. all do not meet inclusive criteria, not by regulation medication, curative effect or data can not be judged It is not congruent to affect the treatment or security judgement person.
2.3 curative effects judge
Cure：Joint structure is normal, and symptom disappears, and function is wholly or substantially recovered.
Improve：Joint structure is normal, and symptom improves, and funtion part is limited.
It is not cured：Dislocation does not reset, and symptom is without improvement, dysfunction.
2.4 medication
Daily 3 times, early, middle and late once a dose, each taking when need to separate more than half an hour with the meal time, Each taking medicine equivalent to 3 grams crude drugs of weight, and need to be taken with yellow rice wine or red wine, to help the efficacy of a drug.
3 experimental results
The experiment results show that 1 month visible positive effect is taken, and pharmaceutical composition of the present invention, total effective rate 100%, this Invention pharmaceutical composition can effectively treat fracture or bone split.
2 medicine composite for curing of the present invention of test example is fractured or the model case of bone split
Case one：XX is opened, female 85 years old, left humerus fracture, fixation, hospital are employed after making film confirmation fracture to hospital Inform that such advanced age needs be possible to fully recover with top for 100 days.Take after this medicine 1 month, patient feels does not have pain completely Sense, it is desirable to which film making verification, takes down fixing device if having fully recovered.Making film to hospital, doctor resolutely opposes to fully recover, Make film afterwards in the case where patient requires again and again, it is surprised to find to heal completely at knochenbruch.
To sum up, pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, and has no adverse reaction, can alleviate rapidly because Feeling of pain caused by fracture, bone split, accelerates patient and gets well, significantly shorten the healing time of fracture or bone split, can effectively control Fracture or bone split are treated, there is stronger actual application value.

Claims (9)

  1. A kind of 1. pharmaceutical composition, it is characterised in that：It is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：Frankincense 30-50 parts, 25-55 parts of myrrh, 28-50 parts of dragon's blood, 20-50 parts of teasel root, 18-42 parts of safflower, 20-40 parts of notopterygium root, levisticum 22-40 Part, 12-38 parts of Chinese ephedra, 6-15 parts of native copper.
  2. 2. pharmaceutical composition according to claim 1, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportioning The preparation formed：35-45 parts of frankincense, 30-50 parts of myrrh, 32-48 parts of dragon's blood, 24-46 parts of teasel root, 20-40 parts of safflower, notopterygium root 22-38 parts, 24-38 parts of levisticum, 15-25 parts of Chinese ephedra, 8-12 parts of native copper.
  3. 3. pharmaceutical composition according to claim 2, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportioning The preparation formed：40 parts of frankincense, 40 parts of myrrh, 40 parts of dragon's blood, 30 parts of teasel root, 30 parts of safflower, 30 parts of notopterygium root, 30 parts of levisticum, fiber crops Yellow 20 parts, 10 parts of native copper.
  4. 4. according to the pharmaceutical composition described in claim 1-3 any one, it is characterised in that：The composition be with frankincense, Myrrh, dragon's blood, teasel root, safflower, notopterygium root, levisticum, the medicinal powder of Chinese ephedra and native copper, or water or extractive with organic solvent are effective Component, pharmaceutically common preparation is prepared into plus pharmaceutically acceptable auxiliary material.
  5. 5. pharmaceutical composition according to claim 4, it is characterised in that：The preparation is oral formulations.
  6. 6. pharmaceutical composition according to claim 5, it is characterised in that：The preparation is powder, decoction, granule, piece Agent, capsule, oral liquid, pill.
  7. 7. the preparation method of the pharmaceutical composition described in claim 1-6 any one, it is characterised in that：It includes following step Suddenly：
    (1) bulk pharmaceutical chemicals of each weight proportion are weighed；
    (2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration, adds pharmacy Upper acceptable auxiliary material or complementary component are prepared into pharmaceutically common preparation.
  8. 8. preparation method according to claim 7, it is characterised in that：Specific preparation method is as follows：
    Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；
    Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；
    Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or complementary Component, mixes, granulation, whole grain, drying, to obtain the final product；
    Tablet：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or complementary component, system Grain, whole grain, tabletting, to obtain the final product；
    Capsule：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, add auxiliary material or it is complementary into Point, mix, it is encapsulated, to obtain the final product；
    The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；
    Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；
    Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, instill Condensed in not miscible condensate liquid, to obtain the final product.
  9. 9. purposes of the pharmaceutical composition in the medicine for the treatment of fracture or bone split is prepared described in claim 1-6 any one.
CN201711329519.4A 2017-12-13 2017-12-13 It is a kind of to treat fracture or the pharmaceutical composition of bone split and its preparation method and application Pending CN108014235A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1138482A (en) * 1996-03-25 1996-12-25 刘建明 Medicine and bone-growing plaster for treatment of fracture

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1138482A (en) * 1996-03-25 1996-12-25 刘建明 Medicine and bone-growing plaster for treatment of fracture

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