CN108126077A - A kind of pharmaceutical composition for treating fracture or bone split and its preparation method and application - Google Patents
A kind of pharmaceutical composition for treating fracture or bone split and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical compositions, it is the preparation that the bulk pharmaceutical chemicals matched by following weight are prepared：15 65 parts of frankincense, 20 60 parts of myrrh, 18 58 parts of dragon's blood, 8 28 parts of native copper, 15 60 parts of Rhizoma Et Radix Notopterygii, 10 55 parts of Radix Angelicae Pubescentis.The present invention also provides the preparation methods and purposes of the pharmaceutical composition.Pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, synergistic, has no adverse reaction, can accelerate patient and get well, and significantly shortens the healing time of fracture or bone split, can effectively treat fracture or bone split, has stronger actual application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions for treating fracture or bone split.
Background technology
Fracture is that the continuity of bone structure is broken completely or partially.Be more common in children and the elderly, young people also when
There is generation.Patient is often-a position fracture, and minority is multiple fracture.Through appropriate processing in time, most patients can restore former
The function of coming, a few patients can leave different degrees of sequelae.
At present clinically for fracture based on operative treatment, by open reset or internal fixation with steel plate pair is used
Fracture portions are treated.However, operative treatment fracture but faces the drawbacks such as high cost, wound are big, complication is more, for example,
Operation can damage periosteum and surrounding soft tissue, influence local blood and supply, extension healing time, and metal inside-fixture
Can occur rejection, and it is possible that postoperative unknown cause hyperpyrexia, the enhancing of fracture periosteal reaction, occur nail trace,
Bone ischemic, bone information and poroma delay the complication such as moulding, and harmful effect is caused to the prognosis of patient.
Orthopedics of Chinese Medicine developing history it is long, show that traditional Chinese medical science conservative treatment can effectively treat fracture according to clinical research,
There is the characteristics of spending less, wound is small, good prognosis compared to operative treatment, be not only able to the recovery of promotion patient health also significantly
The time for shortening union.Chen little Jun, " limbs fracture tcm characteristic therapeutic effect ", Clinical Journal of
Chinese Medicine, the 18th phase in 2012 disclose oral Thyroid Nodules (Radix Astragali 30g, Radix Salviae Miltiorrhizae 20g, HERBA EPIMEDII
20g, Rhizoma Chuanxiong 20g, dipsacus root 20g, Radix Angelicae Sinensis 15g, Fructus Corni 15g, calcined Dragon's bone 15g, cultivated land 15g, Chinese yam 15g, safflower 20g, the radix paeoniae rubrathe
12g, Semen Cuscutae 12g, rhizome of davallia 12g, cortex albiziae 12g, Radix Glycyrrhizae 6g), and manipulative reduction, plintlet is coordinated to fix and the external application of Chinese medicine
Fracture can effectively be treated.Application number：96103489.0 denomination of invention：A kind of drug for treating fracture and long bone patch, it mainly with
Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, frankincense, myrrh, the rhizome of davallia, pyritum ignited, orange peel, dragon's blood, Eupolyphoge sinensis are prepared, which is externally applied drug,
By the way that bulk pharmaceutical chemicals are pulverized, stir evenly and spread on affected part, fracture can be treated.
It now has no the cooperation of frankincense, myrrh, dragon's blood, native copper, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis for treatment fracture or the report of bone split.
Invention content
The present invention provides a kind of pharmaceutical composition for treating fracture or bone split, and its preparation method and application.
The present invention provides a kind of pharmaceutical compositions, it is the preparation that the bulk pharmaceutical chemicals matched by following weight are prepared：
15-65 parts of frankincense, 20-60 parts of myrrh, 18-58 parts of dragon's blood, 8-28 parts of native copper, 15-60 parts of Rhizoma Et Radix Notopterygii, 10-55 parts of Radix Angelicae Pubescentis.
Wherein, it is the preparation that the bulk pharmaceutical chemicals matched by following weight are prepared：15-50 parts of frankincense, myrrh 25-55
Part, 20-55 parts of dragon's blood, 10-25 parts of native copper, 15-50 parts of Rhizoma Et Radix Notopterygii, 15-45 parts of Radix Angelicae Pubescentis.
Wherein, it is the preparation that the bulk pharmaceutical chemicals matched by following weight are prepared：40 parts of frankincense, 40 parts of myrrh, dragon's blood
40 parts, 10 parts of native copper, 30 parts of Rhizoma Et Radix Notopterygii, 30 parts of Radix Angelicae Pubescentis.Wherein, the composition be with frankincense, myrrh, dragon's blood, native copper and
The medicinal powder or water or extractive with organic solvent of Chinese ephedra are active ingredient, in addition pharmaceutically acceptable auxiliary material is prepared into pharmacy
Upper common preparation.
Pharmaceutically acceptable auxiliary material of the present invention refers to the substance being included in addition to the active ingredient (s in dosage form, packet
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifier, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifier includes Tween-80, aliphatic acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary ingredient, it has certain physiological activity, but the addition of the ingredient will not change
Become the leading position of above compound or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work(
Effect is only the utilization to the ingredient known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral preparation.
Wherein, the preparation is powder, decoction, granule, tablet, capsule, oral liquid, pill.
The present invention also extracts the preparation method of aforementioned pharmaceutical composition, it is comprised the following steps：
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder or by bulk pharmaceutical chemicals add water to cook or organic solvent extract, extracting solution concentration, add
Pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition occupation mode, after water carries, since the soluble end of water is wide, and energy
It is enough to dissolve out most of active ingredient, drug is made to be easier to be absorbed by the body, is worked faster, such as the form of medication such as decoction；With
Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of active ingredient in vivo in medicinal material, but medicinal material is un-extracted,
Active ingredient still needs to dissolve out re-absorption in vivo, and the opposite water extract that works is slower, but also weakens and be harmful into medicinal material simultaneously
Divide the toxicity caused by human body, be suitable for taking for a long time, such as original powder is prepared into pill form of medication.At present in pharmacy
In the process, ethyl alcohol extracts drug as solvent and one of most commonly seen extracting mode, ethyl alcohol are molten for semi-polarity
Agent, solubility property circle can dissolve water-soluble certain ingredients between polarity and nonpolar solvent, and it is molten also to dissolve nonpolarity
Some ingredients of agent dissolving usually replace decocting with ethyl alcohol extraction, so as to avoid the dissolution of a large amount of invalid components, improve effectively into
The concentration and extraction efficiency divided, but the price of ethyl alcohol is expensive compared with water, in the big production of modern pharmaceutical industry, is produced into save
This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to
Various productions and demand when using, can optionally water carries, original powder, alcohol extracting or combination thereof method prepare specific agent
Type.
Wherein, specific preparation method is as follows：
Decoction：Weigh bulk pharmaceutical chemicals, decoct, filter to get；
Powder：Weigh bulk pharmaceutical chemicals, beat powder, be sieved to get；
Granule：Bulk pharmaceutical chemicals are weighed, water or organic solvent is added to extract, filtering, filtrate concentration, dry, addition auxiliary material or auxiliary
Helping property ingredient, mixing, granulation, whole grain, it is dry to get；
Tablet：Weigh bulk pharmaceutical chemicals, water or organic solvent added to extract, filtering, filtrate concentration, add in auxiliary material or it is complementary into
Point, granulation, whole grain, tabletting to get；
Capsule：Bulk pharmaceutical chemicals are weighed, water or organic solvent is added to extract, filtering, filtrate is concentrated and dried, and adds in auxiliary material or auxiliary
Property ingredient, mixing, it is encapsulated to get；
The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, be sieved, add in excipient, water pill, it is dry to get；
Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, be sieved, add in honey, pill, it is dry to get；
Dripping pill：Bulk pharmaceutical chemicals are weighed, water or organic solvent is added to extract, filtering adds in matrix in filtrate, mixing heating and melting,
Instill in not miscible condensate liquid condensation to get.
The organic solvent is the ethyl alcohol of various concentration, such as the ethyl alcohol of 25%-95%.
The present invention finally provides purposes of the aforementioned pharmaceutical composition in the drug for the treatment of fracture or bone split is prepared.
Ancient Times in China ancient books and records have description to the treatment after fracture and prognosis.《Plain Questions menstruation regulating opinion》Cloud：" owner of people,
Blood and gas ear ".《Difficulty is difficult through 22》Cloud：" qi warming body, blood nourishing.”《A Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates pieces》Cloud：" part of the body cavity above the diaphragm housing the heart and lungs outlet, with
Warm boundary between muscles and nourishing the bone section ".《This Tibetan of Ling Shu Miraculous Pivot or Divine Axis piece》Cloud：" passages through which vital energy circulates person, so qi and blood circulation promotion and Rong Yinyang, moisten muscles and bones, sharp joint person
".More than ancient books describes out the material base that qi and blood is physical activity, and bone be unable to do without supplementing nutrition for qi and blood；When passages through which vital energy circulates is unimpeded, gas
Blood reconciles, and bone can just obtain and supplement nutrition and make powerful muscle and bone.《General Records of Holy Universal Relief traumatics fracture door》Cloud：" people all over the body, defend by blood Ying Qi, recycles
Infinite or muscles joint accidentally causes to be traumaticd fracture, then qi and blood stasis pain, must not hinder, and must not roll over and continues "." arteries and veins person's house of blood,
It in blood arteries and veins, passes through and is managed in meat, ring Zhou Yishen is logical in passages through which vital energy circulates because solid outside its human body, is that energy streamer does not lose it often.It is if interior because traumatiing fracture
Dynamic channels and collaterals, the road of blood must not declare logical, and siltation does not dissipate, and is pain to swell, and controls and preferably removes evil silt, makes qi and blood circulation, then can be complete again
." Chen Shiduo《The dialectical record of all kinds of diseases and ailments》Cloud：" blood not reviver become silted up do not go, silt do not go then bone cannot connect." it can be seen from the above, fracture
After, it is necessary to passages through which vital energy circulates is unimpeded, and qi and blood reconciliation could heal；If qi depression to blood stasis, passages through which vital energy circulates occlusion, then derangement of Qi and blood, the broken ends of fractured bone obtain not
To nourishing, just it is difficult to heal.In addition,《Plain Questions declares a five gas pieces》Cloud：" Shen controls bone "；《The big opinion of YIN YANG classification of natural phenomena》Cloud：" kidney gives birth to bone
Marrow "；《Six sections are hidden as opinion》Also say：" kidney person, fill in bone ".The vital essence of kidney is explicitly pointed out, bone can be given birth to and brought up.Kidney qi is vigorous then
Bone growth, then bone also fails therewith for kidney qi decline.
It is considered herein that fracture or the interpretation of the cause, onset and process of an illness of bone split are deficiency of kidney-QI, vim and vigour are got along well, and muscles and bones is weak；To proceed blood cycle, mend
Kidney-nourishing essence is treatment fracture or the mechanism of bone split, can nourish kidney qi, the regulation of qi and blood, to achieve the purpose that give birth to and bring up bone, so as to have
Effect treatment fracture or bone split.
In pharmaceutical composition of the present invention, frankincense, myrrh, dragon's blood are monarch drug in a prescription, and blood-activating and qi-promoting relieves pain, removing blood stasis and hemostasis, detumescence life
Flesh；Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis be ministerial drug, wind-expelling pain-stopping；Power the benefits of native copper synthetism is borrowed to act on affected part again.
Pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, synergistic, has no adverse reaction, and can accelerate to suffer from
Person gets well, and significantly shortens the healing time of fracture or bone split, can effectively treat fracture or bone split, has stronger reality should
With value.
Obviously, the above according to the present invention according to the ordinary technical knowledge and customary means of this field, is not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically the above of the present invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
The preparation of 1 medicinal tablet of the present invention of embodiment
Frankincense 40g, myrrh 40g, dragon's blood 40g, native copper 10g, Rhizoma Et Radix Notopterygii 30g, Radix Angelicae Pubescentis 30g are taken, beats powder, powder is directly pressed
Piece is to get tablet.
The preparation of 2 medicinal tablet of the present invention of embodiment
Frankincense 65g, myrrh 60g, dragon's blood 58g, native copper 28g, Rhizoma Et Radix Notopterygii 60g, Radix Angelicae Pubescentis 55g are taken, adds water to cook extraction, concentration
Into medicinal extract, starch granulation, whole grain, tabletting are added in get tablet.
The preparation of 3 medicine capsule of the present invention of embodiment
Frankincense 15g, myrrh 20g, dragon's blood 18g, native copper 8g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Pubescentis 10g are taken, adds water to cook extraction, concentration
Into medicinal extract, auxiliary material is added in, mixing is dispensed to get capsule.
The preparation of the 4 drug water-bindered pill of the present invention of embodiment
Frankincense 50g, myrrh 55g, dragon's blood 55g, native copper 25g, Rhizoma Et Radix Notopterygii 50g, Radix Angelicae Pubescentis 45g are taken, beats powder, is sieved, adds in and assigns
Shape agent, water pill are dry to get the water-bindered pill.
The preparation of 5 drug honeyed bolus of the present invention of embodiment
Frankincense 15g, myrrh 25g, dragon's blood 20g, native copper 10g, Rhizoma Et Radix Notopterygii 15g, Radix Angelicae Pubescentis 15g are taken, beats powder, is sieved, adds in bee
Honey, pill are dry to get honeyed bolus.
The preparation of 6 drug decoction of the present invention of embodiment
Frankincense 40g, myrrh 40g, dragon's blood 40g, native copper 10g, Rhizoma Et Radix Notopterygii 30g, Radix Angelicae Pubescentis 30g are taken, soaks decoction, is merged
Filtrate is filtered to get decoction.
The preparation of 7 medicinal tablet of the present invention of embodiment
Frankincense 50g, myrrh 55g, dragon's blood 55g, native copper 25g, Rhizoma Et Radix Notopterygii 50g, Radix Angelicae Pubescentis 45g are taken, is extracted with ethyl alcohol, obtains second
Alcohol extract is condensed into medicinal extract, adds in starch granulation, whole grain, tabletting to get tablet.
The preparation of 8 medicine oral liquid of the present invention of embodiment
Frankincense 65g, myrrh 60g, dragon's blood 58g, native copper 28g, Rhizoma Et Radix Notopterygii 60g, Radix Angelicae Pubescentis 55g are taken, soaks decoction, is merged
Filtrate, concentration, embedding sterilize to get oral liquid.
Beneficial effects of the present invention are proved below by way of specific clinical test：
1 medicine composite for curing of the present invention of test example is fractured or the clinical efficacy of bone split
1 experiment material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 70, and the age is 42 years old average, are divided into 7 groups, every group of 10 people are respectively of the invention
Pharmaceutical composition group and frankincense, myrrh, dragon's blood, native copper, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis simple group.
2 experimental methods
2.1 are included in case standard：1. it is diagnosed as the patient of fracture.2. it is diagnosed as the patient of bone split.
2.2 Excluded cases standards：1. pregnant woman, those who are allergic to this drug.2. it is associated with angiocarpy, liver, kidney and hemopoietic system etc.
Severe primary disease, mental patient.3. all do not meet inclusion criteria, not by regulation medication, curative effect or data can not be judged
It is not congruent to affect the treatment or safety judgement person.
2.3 curative effects judge
It cures：Joint structure is normal, and symptom disappears, and function is wholly or substantially restored.
It improves：Joint structure is normal, and symptom improves, and funtion part is limited.
It is not cured：Dislocation does not reset, and symptom is without improvement, dysfunction.
2.4 medication
The instructions of taking of pharmaceutical composition of the present invention according to：Daily 3 times, early, middle and late once a dose, each taking
When need to separate more than half an hour with the meal time, each taking the weight of drug be equivalent to 3 grams of crude drugs, and need to yellow rice wine or
Red wine takes, to help the efficacy of a drug.Frankincense, myrrh, dragon's blood, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis simple, daily 3 times, each taking drug
Weight be respectively equivalent to 3 grams of crude drugs.The simple of native copper, daily 3 times, each taking drug weight distinguish phase
When in 0.5 gram of crude drug.
3 experimental results
The experiment results show that 1 month visible positive effect is taken, and pharmaceutical composition of the present invention, total effective rate 100%, list
Taste medicine frankincense, myrrh, dragon's blood, native copper, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis total effective rate be respectively 70%, 60%, 80%, 80%, 50%,
60%.It follows that the effect of pharmaceutical composition of the present invention is significantly better than simple, there is synergy, it can be effective
Treatment fracture or bone split.
To sum up, pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, synergistic, has no adverse reaction, and can add
Fast patient gets well, and significantly shortens the healing time of fracture or bone split, can effectively treat fracture or bone split, has stronger reality
Border application value.
Claims (9)
1. a kind of pharmaceutical composition, it is characterised in that：It is the preparation that the bulk pharmaceutical chemicals matched by following weight are prepared：Frankincense
15-65 parts, 20-60 parts of myrrh, 18-58 parts of dragon's blood, 8-28 parts of native copper, 15-60 parts of Rhizoma Et Radix Notopterygii, 10-55 parts of Radix Angelicae Pubescentis.
2. pharmaceutical composition according to claim 1, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals that following weight matches
The preparation formed：15-50 parts of frankincense, 25-55 parts of myrrh, 20-55 parts of dragon's blood, 10-25 parts of native copper, 15-50 parts of Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis
15-45 parts.
3. pharmaceutical composition according to claim 2, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals that following weight matches
The preparation formed：40 parts of frankincense, 40 parts of myrrh, 40 parts of dragon's blood, 10 parts of native copper, 30 parts of Rhizoma Et Radix Notopterygii, 30 parts of Radix Angelicae Pubescentis.
4. according to the pharmaceutical composition described in claim 1-3 any one, it is characterised in that：The composition be with frankincense,
Myrrh, dragon's blood, native copper, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis medicinal powder or water or extractive with organic solvent be active ingredient, in addition pharmaceutically
Acceptable auxiliary material is prepared into pharmaceutically common preparation.
5. pharmaceutical composition according to claim 4, it is characterised in that：The preparation is oral preparation.
6. pharmaceutical composition according to claim 5, it is characterised in that：The preparation is powder, decoction, granule, piece
Agent, capsule, oral liquid, pill.
7. the preparation method of the pharmaceutical composition described in claim 1-6 any one, it is characterised in that：It includes following step
Suddenly：
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder or by bulk pharmaceutical chemicals add water to cook or organic solvent extract, extracting solution concentration, add pharmacy
Upper acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
8. preparation method according to claim 7, it is characterised in that：Specific preparation method is as follows：
Decoction：Weigh bulk pharmaceutical chemicals, decoct, filter to get；
Powder：Weigh bulk pharmaceutical chemicals, beat powder, be sieved to get；
Granule：Bulk pharmaceutical chemicals are weighed, water or organic solvent is added to extract, filtering, filtrate concentration, dry, addition auxiliary material or complementary
Ingredient, mixing, granulation, whole grain, it is dry to get；
Tablet：Bulk pharmaceutical chemicals are weighed, water or organic solvent is added to extract, filtering, filtrate concentration adds in auxiliary material or complementary ingredient, system
Grain, whole grain, tabletting to get；
Capsule：Weigh bulk pharmaceutical chemicals, water or organic solvent added to extract, filtering, filtrate is concentrated and dried, add in auxiliary material or it is complementary into
Point, mixing, it is encapsulated to get；
The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, be sieved, add in excipient, water pill, it is dry to get；
Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, be sieved, add in honey, pill, it is dry to get；
Dripping pill：Bulk pharmaceutical chemicals are weighed, water or organic solvent is added to extract, is filtered, matrix is added in filtrate, mixing heating and melting instills
In not miscible condensate liquid condense to get.
9. purposes of the pharmaceutical composition in the drug for the treatment of fracture or bone split is prepared described in claim 1-6 any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711331167.6A CN108126077A (en) | 2017-12-13 | 2017-12-13 | A kind of pharmaceutical composition for treating fracture or bone split and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711331167.6A CN108126077A (en) | 2017-12-13 | 2017-12-13 | A kind of pharmaceutical composition for treating fracture or bone split and its preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318147A (en) * | 2021-06-11 | 2021-08-31 | 俏福圣药业有限公司 | Formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660179A (en) * | 2004-12-24 | 2005-08-31 | 朱维俊 | Chinese traditional medicine for treating fracture of senior citizens |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1660179A (en) * | 2004-12-24 | 2005-08-31 | 朱维俊 | Chinese traditional medicine for treating fracture of senior citizens |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318147A (en) * | 2021-06-11 | 2021-08-31 | 俏福圣药业有限公司 | Formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain |
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