CN107929400A - A kind of pharmaceutical composition for treating calculus and its preparation method and application - Google Patents
A kind of pharmaceutical composition for treating calculus and its preparation method and application Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract
The invention discloses a kind of pharmaceutical composition, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：Extra large 85 115 parts of gold sand, 20 40 parts of Radix Paeoniae Alba, 10 30 parts of pyrrosia lingua, 10 30 parts of desmodium, 12 28 parts of honeysuckle, 8 22 parts of radix achyranthis bidentatae, 5 25 parts of RADIX MORINDAE OFFICINALIS, 6 15 parts of radix glycyrrhizae.Present invention also offers the preparation method and purposes of the pharmaceutical composition.Clinical test proves that pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, and has no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, can effectively treat calculus, has stronger actual application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for treating calculus.
Background technology
Calculus refers in the catheter lumen in body or luminal organ (such as kidney, ureter, gall-bladder, bladder and urethra)
Chamber in the solid mass that is formed.Calculus can betide many positions of body, with hepatic duct, gall-bladder, kidney, bladder, urine output
The position such as pipe and urethra is common.It is component, shape, quality contained by the mechanism of calculus, right due to the difference of afflicted organ
Influence of body etc. differs.Generally speaking, calculus can cause tube chamber to block, and influence the discharge of afflicted organ's liquid, produce
The symptoms such as pain, bleeding or secondary infection.Disease morbidity urgency, complicated symptoms, complication are more, high recurrence rate and have canceration
May, it is a kind of stubborn disease.
Doctor trained in Western medicine is broken still with operation or external knock wave for the treatment of hepatic calculus, cholecystolithiasis, kidney stone etc. at present
Based on stone art, wherein operative treatment takes stone, major liver resection, gallbladder removal etc. including bile duct stenosis.In recent years, calculus surgery hand
Art curative effect has been significantly improved, but it is postoperative may still face retained calculus, recurrence of hepatolithiasis and again operation etc. problems.
Calculus belongs in the traditional Chinese medical science category of " urolithiasis ", " sand leaching ", " blood strangury ", " abdominal pain " and " abdominal distension " of " stranguria ", according to facing
Bed research finds that TCM Therapy treatment calculus has the advantages that hurtless measure, adverse reaction are small, cheap and evident in efficacy,
Received at present by numerous calculus patients, especially to some single-shots or little particle calculus, TCM Therapy is into head
Choosing method.Wang Ruifen, " three gold medal Treating Urinary Lithiasis with Paishi Decoction 120, the new traditional Chinese medical science, the 39th phase in 2007 disclose oral three
Golden Paishi Tang (desmodium, the membrane of a chicken's gizzard, curcuma zedoary, trigone, extra large gold sand, radix glycyrrhizae, radix astragali, chingma abutilon seed, the seed of cowherb, corydalis tuber, ox
Knee, teasel root, talcum, Chinese herbaceous peony are given, rhizoma alismatis), and routing motion and hydrotherapy can effectively treat stone in urinary system.Application number：
200510010352.6 denomination of invention：A kind of Chinese medicine preparation for treating lithiasis and preparation method thereof, it is mainly with radix bupleuri, life
33 kinds of Chinese herbal medicines such as Radix Paeoniae Alba, green peel, moutan bark, Radix Curcumae, corydalis tuber, extra large gold sand, desmodium and pig gall bladder are formed through processing；This side
It is high with prodrug complex, drug cost.
Now have no to coordinate extra large gold sand, Radix Paeoniae Alba, pyrrosia lingua, desmodium, honeysuckle, radix achyranthis bidentatae, RADIX MORINDAE OFFICINALIS and radix glycyrrhizae and be used to control
Treat the report of calculus.
The content of the invention
The present invention provides a kind of pharmaceutical composition for treating calculus, and its preparation method and application.
The present invention provides a kind of pharmaceutical composition, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：
Extra large gold sand 85-115 parts, 20-40 parts of Radix Paeoniae Alba, 10-30 parts of pyrrosia lingua, 10-30 parts of desmodium, 12-28 parts of honeysuckle, radix achyranthis bidentatae 8-22
Part, 5-25 parts of RADIX MORINDAE OFFICINALIS, 6-15 parts of radix glycyrrhizae.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：Extra large gold sand 90-110 parts, Radix Paeoniae Alba 25-
35 parts, 14-26 parts of pyrrosia lingua, 12-28 parts of desmodium, 15-25 parts of honeysuckle, 10-20 parts of radix achyranthis bidentatae, 8-22 parts of RADIX MORINDAE OFFICINALIS, radix glycyrrhizae
8-12 parts.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：Extra large 100 parts of gold sand, 30 parts of Radix Paeoniae Alba, stone
20 parts of Wei, 20 parts of desmodium, 20 parts of honeysuckle, 15 parts of radix achyranthis bidentatae, 15 parts of RADIX MORINDAE OFFICINALIS, 10 parts of radix glycyrrhizae.
Wherein, the extra large gold sand is sea gold sand section plant sea gold sand Lygodium japonicum (Thunb.) Sw.'s
Drying and ripening spore；The RADIX MORINDAE OFFICINALIS is the dry root of madder wort Morinda officinalis Morinda officinalis How.
Wherein, the composition is with extra large gold sand, Radix Paeoniae Alba, pyrrosia lingua, desmodium, honeysuckle, radix achyranthis bidentatae, RADIX MORINDAE OFFICINALIS and radix glycyrrhizae
Medicinal powder, or water or extractive with organic solvent are active ingredient, are prepared into plus pharmaceutically acceptable auxiliary material pharmaceutically normal
Preparation.
Pharmaceutically acceptable auxiliary material of the present invention, refers to the material being included in addition to the active ingredient (s in formulation, bag
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifying agent includes Tween-80, aliphatic acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary component, it has certain physiological activity, but the addition of the component will not change
Become the leading position of above-claimed cpd or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work(
Effect is only the utilization to the component known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral formulations.
Wherein, the preparation is powder, decoction, granule, tablet, capsule, oral liquid, pill.
The present invention also extracts the preparation method of foregoing pharmaceutical composition, it is comprised the following steps：
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration, adds
Pharmaceutically acceptable auxiliary material or complementary component are prepared into pharmaceutically common preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition occupation mode, after water carries, since the soluble end of water is wide, and energy
Enough by most of active ingredient dissolution, make medicine be easier to be absorbed by the body, work faster, such as the form of medication such as decoction；With
Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of active ingredient in vivo in medicinal material, but medicinal material is un-extracted,
Active ingredient still needs to the re-absorption of dissolution in vivo, its opposite water extract that works is slower, but also weakens and be harmful into medicinal material at the same time
Divide the toxicity caused by human body, be suitable for long-term use, original powder is such as prepared into pill form of medication.At present in pharmacy
During, ethanol extracts medicine as solvent, and one of most commonly seen extracting mode, and ethanol is molten for semi-polarity
Agent, solubility property circle can dissolve water miscible some components between polarity and nonpolar solvent, can also dissolve nonpolar molten
Some components of agent dissolving, usually replace decocting with ethanol extraction, so as to avoid the dissolution of a large amount of invalid components, raising effectively into
The concentration and extraction efficiency divided, but the price of ethanol is expensive compared with water, in the big production of modern pharmaceutical industry, is produced into save
This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to
Various productions and demand when using, can optionally water carries, original powder, alcohol extracting or combinations thereof method prepare specific agent
Type.
Wherein, specific preparation method is as follows：
Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；
Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；
Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or auxiliary
Helping property component, mixes, granulation, whole grain, drying, to obtain the final product；
Tablet：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or it is complementary into
Point, granulation, whole grain, tabletting, to obtain the final product；
Capsule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, and adds auxiliary material or auxiliary
Property component, mix, it is encapsulated, to obtain the final product；
The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；
Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；
Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting,
Instill in not miscible condensate liquid and condense, to obtain the final product.
The organic solvent is the ethanol of various concentrations, such as the ethanol of 25%-95%.
The present invention finally provides purposes of the foregoing pharmaceutical composition in the medicine for preparing treatment calculus.
Wherein, the medicine is the medicine for the treatment of gall stone, kidney stone, vesical calculus or lithangiuria.Calculus is mainly
Due to this void of internal organs, damp and hot turbid pathogenic factor is taken advantage of a weak point, accumulate smoulder it is poly- do not dissipate, or with the passing of time damp and hot decoct forms.Often with diet, feelings will etc.
It is related.Addiction is pungent, preference for fat and sweet food savoury, or is addicted to drink too, influences transporting and transforming function of the spleen and stomach, accumulates that life is damp and hot, and interior knot is damp and hot to decoct in courage
Endure, with the passing of time can form gall stone；Damp invasion of lower energizer, pents up in lower Jiao, with the passing of time can form kidney or vesical calculus.Disorder of emotion, irritability
Pent-up, catharsis dereliction of duty, bile excretion is unfavorable and with the passing of time pent-up, retention of dampness due to stagnation of QI blood stasis change heat, hot and suffocating to decoct into calculus.
In pharmaceutical composition of the present invention, extra large gold sand is monarch drug in a prescription, and inducing diuresis for treating strangurtia relieves pain；White peony root is used as ministerial medicine, nourishing blood and liver, in delaying
Analgesic, suppressing liver-YANG；Assistant is clearing heat and detoxicating with pyrrosia lingua, desmodium, honeysuckle, inducing diuresis for treating strangurtia；Again with radix achyranthis bidentatae, RADIX MORINDAE OFFICINALIS and sweet
Grass is to make coordinating the drug actions of a prescription and priming power downlink.
The mechanism of medicine composite for curing calculus of the present invention is：By removing damp-heat from the liver and the gallbladder, change internal hygrothermal environment,
Make physical recovery equilibrium state, achieve the purpose that fundamentally to treat calculus；Pharmaceutical composition compatibility of the present invention is precise and appropriate, each taste medicine
Complement each other, have no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, calculus can be effectively treated, has stronger reality should
With value.
Obviously, the above according to the present invention, according to the ordinary technical knowledge and customary means of this area, is not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, remakes further specifically the above of the present invention
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of 1 medicinal tablet of the present invention of embodiment
Take extra large gold sand 100g, Radix Paeoniae Alba 30g, pyrrosia lingua 20g, desmodium 20g, honeysuckle 20g, radix achyranthis bidentatae 15g, RADIX MORINDAE OFFICINALIS 15g,
Radix glycyrrhizae 10g, beats powder, direct powder compression, up to tablet.The extra large gold sand is extra large gold sand section plant sea gold sand Lygodium
The drying and ripening spore of japonicum (Thunb.) Sw.；The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis Morinda
The dry root of officinalis How.
The preparation of 2 medicinal tablet of the present invention of embodiment
Take extra large gold sand 85g, Radix Paeoniae Alba 20g, pyrrosia lingua 10g, desmodium 10g, honeysuckle 12g, radix achyranthis bidentatae 8g, RADIX MORINDAE OFFICINALIS 5g, sweet
Careless 6g, adds water to cook extraction, is condensed into medicinal extract, starch granulation, whole grain, tabletting is added, up to tablet.The extra large gold sand is sea
The drying and ripening spore of gold sand section plant sea gold sand Lygodium japonicum (Thunb.) Sw.；The RADIX MORINDAE OFFICINALIS is madder
The dry root of careless section plant Morinda officinalis Morinda officinalis How.
The preparation of 3 medicine capsule of the present invention of embodiment
Take extra large gold sand 115g, Radix Paeoniae Alba 40g, pyrrosia lingua 30g, desmodium 30g, honeysuckle 28g, radix achyranthis bidentatae 22g, RADIX MORINDAE OFFICINALIS 25g,
Radix glycyrrhizae 15g, adds water to cook extraction, is condensed into medicinal extract, adds auxiliary material, mixes, packing, up to capsule.The extra large gold sand is
The drying and ripening spore of extra large gold sand section plant sea gold sand Lygodium japonicum (Thunb.) Sw.；The RADIX MORINDAE OFFICINALIS is
The dry root of madder wort Morinda officinalis Morinda officinalis How.
The preparation of the medicine water-bindered pill of the present invention of embodiment 4
Take extra large gold sand 90g, Radix Paeoniae Alba 25g, pyrrosia lingua 14g, desmodium 12g, honeysuckle 15g, radix achyranthis bidentatae 10g, RADIX MORINDAE OFFICINALIS 8g, sweet
Careless 8g, beats powder, sieving, adds excipient, water pill is dry, up to the water-bindered pill.The extra large gold sand is extra large gold sand section plant Hai Jin
The drying and ripening spore of sand Lygodium japonicum (Thunb.) Sw.；The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis
The dry root of Morinda officinalis How.
The preparation of the medicine honeyed bolus of the present invention of embodiment 5
Take extra large gold sand 110g, Radix Paeoniae Alba 35g, pyrrosia lingua 26g, desmodium 28g, honeysuckle 25g, radix achyranthis bidentatae 20g, RADIX MORINDAE OFFICINALIS 22g,
Radix glycyrrhizae 12g, beats powder, sieving, adds honey, pill is dry, up to honeyed bolus.The extra large gold sand is extra large gold sand section plant Hai Jin
The drying and ripening spore of sand Lygodium japonicum (Thunb.) Sw.；The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis
The dry root of Morinda officinalis How.
The preparation of the medicine decoction of the present invention of embodiment 6
Take extra large gold sand 100g, Radix Paeoniae Alba 30g, pyrrosia lingua 20g, desmodium 20g, honeysuckle 20g, radix achyranthis bidentatae 15g, RADIX MORINDAE OFFICINALIS 15g,
Radix glycyrrhizae 10g, soaks decoction, merging filtrate, filtering, up to decoction.The extra large gold sand is extra large gold sand section plant sea gold sand
The drying and ripening spore of Lygodium japonicum (Thunb.) Sw.；The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis
The dry root of Morinda officinalis How.
The preparation of 7 medicinal tablet of the present invention of embodiment
Take extra large gold sand 110g, Radix Paeoniae Alba 35g, pyrrosia lingua 26g, desmodium 28g, honeysuckle 25g, radix achyranthis bidentatae 20g, RADIX MORINDAE OFFICINALIS 22g,
Radix glycyrrhizae 12g, is extracted with ethanol, obtains ethanol extract, is condensed into medicinal extract, starch granulation, whole grain, tabletting is added, up to tablet.
The extra large gold sand is the drying and ripening spore of sea gold sand section plant sea gold sand Lygodium japonicum (Thunb.) Sw.；
The RADIX MORINDAE OFFICINALIS is the dry root of madder wort Morinda officinalis Morinda officinalis How.
The preparation of 8 medicine oral liquid of the present invention of embodiment
Take extra large gold sand 115g, Radix Paeoniae Alba 40g, pyrrosia lingua 30g, desmodium 30g, honeysuckle 28g, radix achyranthis bidentatae 22g, RADIX MORINDAE OFFICINALIS 25g,
Radix glycyrrhizae 15g, soaks decoction, merging filtrate, concentration, embedding, sterilizing, up to oral liquid.The extra large gold sand is extra large gold sand
The drying and ripening spore of section plant sea gold sand Lygodium japonicum (Thunb.) Sw.；The RADIX MORINDAE OFFICINALIS is Rubiaceae
The dry root of plant Morinda officinalis Morinda officinalis How.
Beneficial effects of the present invention are proved below by way of specific clinical test：
The clinical efficacy of the medicine composite for curing calculus of the present invention of test example 1
1 experiment material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 41, and the age is 50 years old average.
2 experimental methods
2.1 include case standard：1. being diagnosed as lithangiuria includes kidney stone, ureteral calculi, vesical calculus and urethra
The patient of calculus.2. it is diagnosed as the patient of gall stone.
2.2 Excluded cases standards：1. gestation or women breast-feeding their children, those who are allergic to this drug.2. it is associated with angiocarpy, liver, kidney
With the severe primary disease such as hemopoietic system, mental patient.3. all do not meet inclusive criteria, not by regulation medication, can not sentence
Disconnected curative effect or data be not congruent to affect the treatment or security judgement person.
2.3 curative effects judge
It is effective：After the 1-2 course for the treatment of of taking medicine, sings and symptoms disappears, imageological examination, and calculus disappears.
Effectively：After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, imageological examination, calculus to reduce or become before relatively treating
Small person.
It is invalid：After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, or unchanged, and imageological examination, calculus is without change
Person.
2.4 medication
10 days before medication, daily 2-3 times, each taking when need to separate more than half an hour with the meal time, every time
Equivalent to 6 grams crude drugs of the weight for the medicine taken；Later 2 times a day, each taking medicine equivalent to 3 grams crude drugs of weight.
3 experimental results
The experiment results show that take 2 months visible positive effects, pharmaceutical composition of the present invention, total effective rate 98%, this hair
Bright pharmaceutical composition can effectively treat calculus.
The model case of the medicine composite for curing calculus of the present invention of test example 2
Case one：Wu X, male, 45 years old, lithangiuria morbidity in 2014 was in great pain, takes this medicine and owns after 1 month
Sense of discomfort disappears.
Case two：XX women, 57 years old, more than ten years Patients with Cholelithiasis, affected part indistinct pain often, takes after this medicine 60 days
All malaise symptoms disappear, and continue to take 30 days and consolidate, non-re-pull.
To sum up, the mechanism of medicine composite for curing calculus of the present invention is：By removing damp-heat from the liver and the gallbladder, change internal damp and hot
Environment, makes physical recovery equilibrium state, achievees the purpose that fundamentally to treat calculus；Pharmaceutical composition compatibility of the present invention is precise and appropriate,
Each taste medicine complements each other, and has no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, can effectively treat calculus, has stronger
Actual application value.
Claims (10)
- A kind of 1. pharmaceutical composition, it is characterised in that：It is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportioning：Hai Jin 85-115 parts of sand, 20-40 parts of Radix Paeoniae Alba, 10-30 parts of pyrrosia lingua, 10-30 parts of desmodium, 12-28 parts of honeysuckle, 8-22 parts of radix achyranthis bidentatae, 5-25 parts of RADIX MORINDAE OFFICINALIS, 6-15 parts of radix glycyrrhizae.
- 2. pharmaceutical composition according to claim 1, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportioning The preparation formed：Extra large gold sand 90-110 parts, 25-35 parts of Radix Paeoniae Alba, 14-26 parts of pyrrosia lingua, 12-28 parts of desmodium, honeysuckle 15-25 Part, 10-20 parts of radix achyranthis bidentatae, 8-22 parts of RADIX MORINDAE OFFICINALIS, 8-12 parts of radix glycyrrhizae.
- 3. pharmaceutical composition according to claim 2, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportioning The preparation formed：Extra large 100 parts of gold sand, 30 parts of Radix Paeoniae Alba, 20 parts of pyrrosia lingua, 20 parts of desmodium, 20 parts of honeysuckle, radix achyranthis bidentatae 15 part, bar 15 parts of halberd meat, 10 parts of radix glycyrrhizae.
- 4. according to the pharmaceutical composition described in claim 1-3 any one, it is characterised in that：The composition is with Hai Jin Sand, Radix Paeoniae Alba, pyrrosia lingua, desmodium, honeysuckle, radix achyranthis bidentatae, RADIX MORINDAE OFFICINALIS and the medicinal powder of radix glycyrrhizae, or water or extractive with organic solvent be Active ingredient, pharmaceutically common preparation is prepared into plus pharmaceutically acceptable auxiliary material.
- 5. pharmaceutical composition according to claim 4, it is characterised in that：The preparation is oral formulations.
- 6. pharmaceutical composition according to claim 5, it is characterised in that：The preparation is powder, decoction, granule, piece Agent, capsule, oral liquid, pill.
- 7. the preparation method of the pharmaceutical composition described in claim 1-6 any one, it is characterised in that：It includes following step Suddenly：(1) bulk pharmaceutical chemicals of each weight proportion are weighed；(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration, adds pharmacy Upper acceptable auxiliary material or complementary component are prepared into pharmaceutically common preparation.
- 8. preparation method according to claim 7, it is characterised in that：Specific preparation method is as follows：Decoction：Bulk pharmaceutical chemicals are weighed, are decocted, filtering, to obtain the final product；Powder：Weigh bulk pharmaceutical chemicals, beat powder, sieve, to obtain the final product；Granule：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, dry, addition auxiliary material or complementary Component, mixes, granulation, whole grain, drying, to obtain the final product；Tablet：Bulk pharmaceutical chemicals are weighed, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or complementary component, system Grain, whole grain, tabletting, to obtain the final product；Capsule：Weigh bulk pharmaceutical chemicals, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, add auxiliary material or it is complementary into Point, mix, it is encapsulated, to obtain the final product；The water-bindered pill：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add excipient, water pill is dry, to obtain the final product；Honeyed bolus：Weigh bulk pharmaceutical chemicals, beat powder, sieve, add honey, pill is dry, to obtain the final product；Dripping pill：Bulk pharmaceutical chemicals are weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, instill Condensed in not miscible condensate liquid, to obtain the final product.
- 9. purposes of the pharmaceutical composition in the medicine for preparing treatment calculus described in claim 1-6 any one.
- 10. purposes according to claim 9, it is characterised in that：The medicine is treatment gall stone, kidney stone, bladder knot The medicine of stone or lithangiuria.
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| CN201711242926.1A CN107929400A (en) | 2017-11-30 | 2017-11-30 | A kind of pharmaceutical composition for treating calculus and its preparation method and application |
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| CN201711242926.1A CN107929400A (en) | 2017-11-30 | 2017-11-30 | A kind of pharmaceutical composition for treating calculus and its preparation method and application |
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| CN1751734A (en) * | 2005-09-13 | 2006-03-29 | 郭德润 | Traditional Chinese medicine prepn. for treating lithiasis and its prepn. method |
| CN102579855A (en) * | 2011-01-07 | 2012-07-18 | 孟凡化 | Medicament (stone removing powder) for treating kidney stone and preparation method of medicament |
| CN103385934A (en) * | 2012-05-08 | 2013-11-13 | 陈�田 | Traditional Chinese medicine composition used for treating kidney stone, and application thereof |
| CN104189760A (en) * | 2014-09-12 | 2014-12-10 | 四川圣湖生物科技有限公司 | Medicine composition for treating calculus and preparation method and application thereof |
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2017
- 2017-11-30 CN CN201711242926.1A patent/CN107929400A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1751734A (en) * | 2005-09-13 | 2006-03-29 | 郭德润 | Traditional Chinese medicine prepn. for treating lithiasis and its prepn. method |
| CN102579855A (en) * | 2011-01-07 | 2012-07-18 | 孟凡化 | Medicament (stone removing powder) for treating kidney stone and preparation method of medicament |
| CN103385934A (en) * | 2012-05-08 | 2013-11-13 | 陈�田 | Traditional Chinese medicine composition used for treating kidney stone, and application thereof |
| CN104189760A (en) * | 2014-09-12 | 2014-12-10 | 四川圣湖生物科技有限公司 | Medicine composition for treating calculus and preparation method and application thereof |
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