CN107823481A - A kind of pharmaceutical composition for treating calculus and its production and use - Google Patents
A kind of pharmaceutical composition for treating calculus and its production and use Download PDFInfo
- Publication number
- CN107823481A CN107823481A CN201711242927.6A CN201711242927A CN107823481A CN 107823481 A CN107823481 A CN 107823481A CN 201711242927 A CN201711242927 A CN 201711242927A CN 107823481 A CN107823481 A CN 107823481A
- Authority
- CN
- China
- Prior art keywords
- parts
- bulk drug
- pharmaceutical composition
- preparation
- weighed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of pharmaceutical composition, and it is the preparation being prepared by the bulk drug of following weight proportioning：85 115 parts of reed rhizome, 35 65 parts of felwort, 20 40 parts of Poria cocos, 22 38 parts of the bighead atractylodes rhizome, 12 28 parts of radix bupleuri, 12 28 parts of pyrrosia lingua, 8 22 parts of akebi, 6 15 parts of safflower.Present invention also offers the preparation method of the pharmaceutical composition and purposes.Clinical test proves that pharmaceutical composition compatibility of the present invention is precise and appropriate, and each taste medicine complements each other, and has no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, can effectively treat calculus, has stronger actual application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for treating calculus.
Background technology
Calculus refers in the catheter lumen in body or luminal organ (such as kidney, ureter, gall-bladder, bladder and urethra)
Chamber in the solid mass that is formed.Calculus can betide many positions of body, with hepatic duct, gall-bladder, kidney, bladder, urine output
The position such as pipe and urethra is common.It is composition, shape, quality contained by the mechanism of calculus, right due to the difference of afflicted organ
Influence of body etc. differs.Generally speaking, calculus can cause tube chamber to block, and influence the discharge of afflicted organ's liquid, produce
The symptoms such as pain, bleeding or secondary infection.Disease morbidity urgency, complicated symptoms, complication are more, high recurrence rate and have canceration
May, it is a kind of stubborn disease.
Doctor trained in Western medicine is broken still with operation or external knock wave for the treatment of hepatic calculus, cholecystolithiasis, kidney stone etc. at present
Based on stone art, wherein operative treatment takes stone, major liver resection, gallbladder removal etc. including bile duct stenosis.In recent years, calculus surgery hand
Art curative effect has been significantly improved, but it is postoperative may still face retained calculus, recurrence of hepatolithiasis and again operation etc. problems.
Calculus belongs in the traditional Chinese medical science category of " urolithiasis ", " sand leaching ", " blood strangury ", " stomachache " and " abdominal distension " of " stranguria ", according to facing
Bed research finds that TCM Therapy treatment calculus has the advantages that hurtless measure, adverse reaction are small, cheap and evident in efficacy,
Received at present by numerous calculus patients, especially to some single-shots or little particle calculus, TCM Therapy is into head
Choosing method.Wang Ruifen, " three gold medal Treating Urinary Lithiasis with Paishi Decoction 120, the new traditional Chinese medical science, the 39th phase in 2007 disclose oral three
Golden Paishi Tang (desmodium, the membrane of a chicken's gizzard, curcuma zedoary, Rhizoma Sparganii, extra large gold sand, radix glycyrrhizae, the Radix Astragali, chingma abutilon seed, the seed of cowherb, corydalis tuber, ox
Knee, teasel root, talcum, Chinese herbaceous peony are given, rhizoma alismatis), and routing motion and hydrotherapy can effectively treat stone in urinary system.Application number：
200510010352.6 denomination of invention：A kind of Chinese medicine preparation for treating lithiasis and preparation method thereof, it is mainly with radix bupleuri, life
33 kinds of Chinese herbal medicines such as the root of herbaceous peony, rascal, moutan bark, root tuber of aromatic turmeric, corydalis tuber, extra large gold sand, desmodium and pig gall bladder form through processing；This side
It is high with prodrug complex, drug cost.
Now have no and coordinate reed rhizome, felwort, Poria cocos, the bighead atractylodes rhizome, radix bupleuri, pyrrosia lingua, akebi and safflower for treating calculus
Report.
The content of the invention
The invention provides a kind of pharmaceutical composition for treating calculus, and its production and use.
The invention provides a kind of pharmaceutical composition, and it is the preparation being prepared by the bulk drug of following weight proportioning：
Reed rhizome 85-115 parts, felwort 35-65 parts, Poria cocos 20-40 parts, bighead atractylodes rhizome 22-38 parts, radix bupleuri 12-28 parts, pyrrosia lingua 12-28 parts, wood
Logical 8-22 parts, safflower 6-15 parts.
Wherein, it is the preparation being prepared by the bulk drug of following weight proportioning：Reed rhizome 90-110 parts, felwort 40-
60 parts, Poria cocos 25-35 parts, bighead atractylodes rhizome 24-36 parts, radix bupleuri 15-25 parts, pyrrosia lingua 14-26 parts, akebi 10-20 parts, safflower 8-12 parts.
Wherein, it is the preparation being prepared by the bulk drug of following weight proportioning：100 parts of reed rhizome, 50 parts of felwort, Fu
30 parts of Siberian cocklebur, 30 parts of the bighead atractylodes rhizome, 20 parts of radix bupleuri, 20 parts of pyrrosia lingua, 15 parts of akebi, 10 parts of safflower.
Wherein, the composition be with the medicinal powder of reed rhizome, felwort, Poria cocos, the bighead atractylodes rhizome, radix bupleuri, pyrrosia lingua, akebi and safflower,
Or water or extractive with organic solvent are active ingredient, pharmaceutically conventional system is prepared into plus pharmaceutically acceptable auxiliary material
Agent.
Pharmaceutically acceptable auxiliary material of the present invention, refer to the material being included in addition to the active ingredient (s in formulation, bag
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, regulation
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifying agent, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifying agent includes Tween-80, aliphatic acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary composition, it has certain physiologically active, but the addition of the composition will not change
Become the leading position of above-claimed cpd or derivative in treatment of diseases, and only play auxiliary effect, these auxiliary work(
Effect is only the utilization to the composition known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary into
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral formulations.
Wherein, the preparation is powder, decoction, granule, tablet, capsule, oral liquid, pill.
The present invention also extracts the preparation method of foregoing pharmaceutical composition, and it is comprised the following steps：
(1) bulk drug of each weight proportion is weighed；
(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds
Pharmaceutically acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition occupation mode, after water extraction, because the soluble end of water is wide, and energy
Enough by most of active ingredient dissolution, make medicine be easier to be absorbed by the body, work faster, such as the form of medication such as decoction；With
Former powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of active ingredient in vivo in medicinal material, but medicinal material is un-extracted,
Active ingredient still needs to the re-absorption of dissolution in vivo, and its relative water extract that works is slower, but also weakens and be harmful into medicinal material simultaneously
Divide the toxicity to caused by human body, be suitable for long-term use, former powder is such as prepared into pill form of medication.At present in pharmacy
During, ethanol extracts as solvent to medicine, and one of most commonly seen extracting mode, and ethanol is that semi-polarity is molten
Agent, solubility property circle can dissolve water miscible some compositions between polarity and non-polar solven, can also dissolve nonpolar molten
Some compositions of agent dissolving, generally replace decocting with ethanol extraction, so as to avoid the dissolution of a large amount of invalid components, raising effectively into
The concentration and extraction efficiency divided, but the price of ethanol is expensive compared with water, in the big production of modern pharmaceutical industry, is produced into save
This, generally or based on decocting.In the case where the water extract of known compositions of the present invention has physiologically active, in order to adapt to
Various productions and demand when using, optionally water extraction, former powder, alcohol extracting or combinations thereof method can prepare specific agent
Type.
Wherein, specific preparation method is as follows：
Decoction：Bulk drug is weighed, is decocted, filtering, is produced；
Powder：Bulk drug is weighed, beats powder, sieves, produces；
Granule：Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate concentration, dries, adds auxiliary material or auxiliary
Helping property composition, mix, granulation, whole grain, drying, produce；
Tablet：Weigh bulk drug, add water or organic solvent to extract, filtering, filtrate concentration, add auxiliary material or it is complementary into
Point, granulation, whole grain, tabletting, produce；
Capsule：Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate is concentrated and dried, and adds auxiliary material or auxiliary
Property composition, mix, it is encapsulated, produce；
The water-bindered pill：Bulk drug is weighed, beats powder, is sieved, excipient is added, water pill, dries, produce；
Honeyed bolus：Bulk drug is weighed, beats powder, is sieved, honey is added, pill, dries, produce；
Dripping pill：Bulk drug is weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting,
Instill in not miscible condensate liquid and condense, produce.
Described organic solvent is the ethanol of various concentrations, such as 25%-95% ethanol.
The present invention finally provides purposes of the foregoing pharmaceutical composition in the medicine for preparing treatment calculus.
Wherein, the medicine is the medicine for the treatment of gall stone, kidney stone, vesical calculus or lithangiuria.
Calculus is taken advantage of a weak point mainly due to this void of internal organs, damp and hot turbid pathogenic factor, accumulate smoulder it is poly- do not dissipate, or it is damp and hot decoct with the passing of time and
Into.It is often relevant with diet, feelings will etc..Addiction is pungent, preference for fat and sweet food savoury, or is addicted to drink too, influences transporting and transforming function of the spleen and stomach, and it is wet to accumulate life
Heat, inside tie in courage, it is damp and hot to decoct, it with the passing of time can form gall stone；Damp invasion of lower energizer, pent up in lower Jiao, with the passing of time can form kidney or bladder
Calculus.Disorder of emotion, stagnation of liver qi, catharsis dereliction of duty, bile excretion is unfavorable and with the passing of time pent-up, retention of dampness due to stagnation of QI blood stasis change heat, hot and suffocating
Decoct and form calculus.
In pharmaceutical composition of the present invention, reed rhizome, felwort are monarch drug in a prescription, reducing fever and causing diuresis, purging the liver of pathogenic fire is calmed the frightened；Poria cocos, the bighead atractylodes rhizome, radix bupleuri
For ministerial drug, inducing diuresis for treating strangurtia, smooth liver and relieve pain；Assistant is expelled the heat-evil with pyrrosia lingua, akebi and safflower, promoting diuresis for stranguria, clearing lung-heat.
The mechanism of medicine composite for curing calculus of the present invention is：By removing damp-heat from the liver and the gallbladder, change internal hygrothermal environment,
Make physical recovery poised state, reach the purpose for fundamentally treating calculus；Pharmaceutical composition compatibility of the present invention is precise and appropriate, each taste medicine
Complement each other, have no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, calculus can be effectively treated, has stronger reality should
With value.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The embodiment of form by the following examples, the above of the present invention is remake further specifically
It is bright.But the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of 1 medicinal tablet of the present invention of embodiment
Reed rhizome 100g, felwort 50g, Poria cocos 30g, bighead atractylodes rhizome 30g, radix bupleuri 20g, pyrrosia lingua 20g, akebi 15g, safflower 10g are taken,
Powder is beaten, direct powder compression, produces tablet.
The preparation of 2 medicinal tablet of the present invention of embodiment
Reed rhizome 115g, felwort 65g, Poria cocos 40g, bighead atractylodes rhizome 38g, radix bupleuri 28g, pyrrosia lingua 28g, akebi 22g, safflower 15g are taken,
Add water to cook extraction, be condensed into medicinal extract, add starch granulation, whole grain, tabletting, produce tablet.
The preparation of 3 medicine capsule of the present invention of embodiment
Reed rhizome 85g, felwort 35g, Poria cocos 20g, bighead atractylodes rhizome 22g, radix bupleuri 12g, pyrrosia lingua 12g, akebi 8g, safflower 6g are taken, is added
Water boiling and extraction, medicinal extract is condensed into, adds auxiliary material, mixed, packing, produce capsule.
The preparation of the medicine water-bindered pill of the present invention of embodiment 4
Reed rhizome 90g, felwort 40g, Poria cocos 25g, bighead atractylodes rhizome 24g, radix bupleuri 15g, pyrrosia lingua 14g, akebi 10g, safflower 8g are taken, is beaten
Powder, sieving, excipient is added, water pill, dries, produces the water-bindered pill.
The preparation of the medicine honeyed bolus of the present invention of embodiment 5
Reed rhizome 110g, felwort 60g, Poria cocos 35g, bighead atractylodes rhizome 36g, radix bupleuri 25g, pyrrosia lingua 26g, akebi 20g, safflower 12g are taken,
Powder is beaten, sieving, honey is added, pill, dries, produce honeyed bolus.
The preparation of the medicine decoction of the present invention of embodiment 6
Reed rhizome 100g, felwort 50g, Poria cocos 30g, bighead atractylodes rhizome 30g, radix bupleuri 20g, pyrrosia lingua 20g, akebi 15g, safflower 10g are taken,
Decoction is soaked, merging filtrate, filtering, produces decoction.
The preparation of 7 medicinal tablet of the present invention of embodiment
Reed rhizome 90g, felwort 40g, Poria cocos 25g, bighead atractylodes rhizome 24g, radix bupleuri 15g, pyrrosia lingua 14g, akebi 10g, safflower 8g are taken, is used
Ethanol extracts, and obtains ethanol extract, is condensed into medicinal extract, adds starch granulation, whole grain, tabletting, produces tablet.
The preparation of 8 medicine oral liquid of the present invention of embodiment
Reed rhizome 110g, felwort 60g, Poria cocos 35g, bighead atractylodes rhizome 36g, radix bupleuri 25g, pyrrosia lingua 26g, akebi 20g, safflower 12g are taken,
Decoction is soaked, merging filtrate, concentration, embedding, sterilizing, produces oral liquid.
Beneficial effects of the present invention are proved below by way of specific clinical test：
The clinical efficacy of the medicine composite for curing calculus of the present invention of test example 1
1 experiment material
1.1 Experimental agents pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 35, and the age is average 50 years old.
2 experimental methods
2.1 include case standard：1. being diagnosed as lithangiuria includes kidney stone, ureteral calculi, vesical calculus and urethra
The patient of calculus.2. it is diagnosed as the patient of gall stone.
2.2 Excluded cases standards：1. gestation or women breast-feeding their children, those who are allergic to this drug.2. it is associated with angiocarpy, liver, kidney
With the severe primary disease such as hemopoietic system, mental patient.3. all do not meet inclusive criteria, not by regulation medication, can not sentence
Disconnected curative effect or data be not congruent to affect the treatment or security judgement person.
2.3 curative effects judge
It is effective：After the 1-2 course for the treatment of of taking medicine, sings and symptoms disappears.Imageological examination, calculus disappear.
Effectively：After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, imageological examination, calculus to reduce or become before relatively treating
Small person.
It is invalid：After the 1-2 course for the treatment of of taking medicine, sings and symptoms has mitigation, or unchanged, and imageological examination, calculus is without change
Person.
2.4 medication
10 days before medication, daily 2-3 times, each taking when need to separate more than half an hour with the meal time, every time
Equivalent to 6 grams crude drugs of the weight for the medicine taken；Later 2 times a day, each taking medicine equivalent to 3 grams crude drugs of weight.
3 experimental results
Experimental result illustrates, takes 2 months visible positive effects, pharmaceutical composition of the present invention, total effective rate 100%, sheet
Invention pharmaceutical composition can effectively treat calculus.
The model case of the medicine composite for curing calculus of the present invention of test example 2
Song XX, male, 40 years old, burst kidney stone in 2016 was in great pain, suggests laser lithotripsy after removing hospital admission, suffers from
Person is reluctant to select this treatment method, this medicine is taken after going back, all malaise symptoms are wholly absent after 40 days, are not recurred again so far.
To sum up, the mechanism of medicine composite for curing calculus of the present invention is：By removing damp-heat from the liver and the gallbladder, change internal damp and hot
Environment, make physical recovery poised state, reach the purpose for fundamentally treating calculus；Pharmaceutical composition compatibility of the present invention is precise and appropriate,
Each taste medicine complements each other, and has no toxic side effect, can be small by changing greatly by calculus, by smallization nothing, can effectively treat calculus, has stronger
Actual application value.
Claims (10)
- A kind of 1. pharmaceutical composition, it is characterised in that：It is the preparation being prepared by the bulk drug of following weight proportioning：Reed rhizome 85-115 parts, felwort 35-65 parts, Poria cocos 20-40 parts, bighead atractylodes rhizome 22-38 parts, radix bupleuri 12-28 parts, pyrrosia lingua 12-28 parts, akebi 8- 22 parts, safflower 6-15 parts.
- 2. pharmaceutical composition according to claim 1, it is characterised in that：It is prepared by the bulk drug of following weight proportioning The preparation formed：Reed rhizome 90-110 parts, felwort 40-60 parts, Poria cocos 25-35 parts, bighead atractylodes rhizome 24-36 parts, radix bupleuri 15-25 parts, stone Wei 14-26 parts, akebi 10-20 parts, safflower 8-12 parts.
- 3. pharmaceutical composition according to claim 2, it is characterised in that：It is prepared by the bulk drug of following weight proportioning The preparation formed：100 parts of reed rhizome, 50 parts of felwort, 30 parts of Poria cocos, 30 parts of the bighead atractylodes rhizome, 20 parts of radix bupleuri, 20 parts of pyrrosia lingua, 15 parts of akebi, 10 parts of safflower.
- 4. according to the pharmaceutical composition described in claim 1-3 any one, it is characterised in that：The composition be with reed rhizome, Felwort, Poria cocos, the bighead atractylodes rhizome, radix bupleuri, pyrrosia lingua, the medicinal powder of akebi and safflower, or water or extractive with organic solvent are active ingredient, Pharmaceutically conventional preparation is prepared into plus pharmaceutically acceptable auxiliary material.
- 5. pharmaceutical composition according to claim 4, it is characterised in that：The preparation is oral formulations.
- 6. pharmaceutical composition according to claim 5, it is characterised in that：The preparation is powder, decoction, granule, piece Agent, capsule, oral liquid, pill.
- 7. the preparation method of the pharmaceutical composition described in claim 1-6 any one, it is characterised in that：It includes following step Suddenly：(1) bulk drug of each weight proportion is weighed；(2) bulk drug directly beats powder, or bulk drug is added water to cook or organic solvent extracts, and extract solution concentration, adds pharmacy Upper acceptable auxiliary material or complementary composition are prepared into pharmaceutically conventional preparation.
- 8. preparation method according to claim 7, it is characterised in that：Specific preparation method is as follows：Decoction：Bulk drug is weighed, is decocted, filtering, is produced；Powder：Bulk drug is weighed, beats powder, sieves, produces；Granule：Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate concentration, dries, adds auxiliary material or complementary Composition, mix, granulation, whole grain, drying, produce；Tablet：Bulk drug is weighed, adds water or organic solvent to extract, filtering, filtrate concentration, adds auxiliary material or complementary composition, system Grain, whole grain, tabletting, are produced；Capsule：Weigh bulk drug, add water or organic solvent to extract, filtering, filtrate is concentrated and dried, add auxiliary material or it is complementary into Point, mix, it is encapsulated, produce；The water-bindered pill：Bulk drug is weighed, beats powder, is sieved, excipient is added, water pill, dries, produce；Honeyed bolus：Bulk drug is weighed, beats powder, is sieved, honey is added, pill, dries, produce；Dripping pill：Bulk drug is weighed, adds water or organic solvent to extract, filters, matrix is added in filtrate, mix heating and melting, instill Condense, produce in not miscible condensate liquid.
- 9. purposes of the pharmaceutical composition in the medicine for preparing treatment calculus described in claim 1-6 any one.
- 10. purposes according to claim 9, it is characterised in that：The medicine is treatment gall stone, kidney stone, bladder knot The medicine of stone or lithangiuria.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711242927.6A CN107823481A (en) | 2017-11-30 | 2017-11-30 | A kind of pharmaceutical composition for treating calculus and its production and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711242927.6A CN107823481A (en) | 2017-11-30 | 2017-11-30 | A kind of pharmaceutical composition for treating calculus and its production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107823481A true CN107823481A (en) | 2018-03-23 |
Family
ID=61647348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711242927.6A Pending CN107823481A (en) | 2017-11-30 | 2017-11-30 | A kind of pharmaceutical composition for treating calculus and its production and use |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107823481A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1751734A (en) * | 2005-09-13 | 2006-03-29 | 郭德润 | Traditional Chinese medicine prepn. for treating lithiasis and its prepn. method |
| CN101549113A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating urinary system stones and preparation method thereof |
| CN104189760A (en) * | 2014-09-12 | 2014-12-10 | 四川圣湖生物科技有限公司 | Medicine composition for treating calculus and preparation method and application thereof |
| CN105287973A (en) * | 2015-11-30 | 2016-02-03 | 林弓 | Traditional Chinese medicine composition for curing calculi as well as preparation and preparation method thereof |
-
2017
- 2017-11-30 CN CN201711242927.6A patent/CN107823481A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1751734A (en) * | 2005-09-13 | 2006-03-29 | 郭德润 | Traditional Chinese medicine prepn. for treating lithiasis and its prepn. method |
| CN101549113A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating urinary system stones and preparation method thereof |
| CN104189760A (en) * | 2014-09-12 | 2014-12-10 | 四川圣湖生物科技有限公司 | Medicine composition for treating calculus and preparation method and application thereof |
| CN105287973A (en) * | 2015-11-30 | 2016-02-03 | 林弓 | Traditional Chinese medicine composition for curing calculi as well as preparation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘富强: "龙胆泻肝汤治疗泌尿系结石", 《四川中医》 * |
| 赖海标 等: "中医药防治肾结石的临床研究进展", 《中国药业》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102671178A (en) | Chinese medicinal composition for treating nephrotic syndrome and uremia and preparation method and application thereof | |
| CN106994141B (en) | Traditional Chinese medicine composition for treating constipation and preparation method thereof | |
| CN107929354A (en) | A kind of pharmaceutical composition for treating calculus and its preparation method and application | |
| CN107823481A (en) | A kind of pharmaceutical composition for treating calculus and its production and use | |
| CN100415266C (en) | A Chinese traditional medicinal preparation for treatment of eczema | |
| CN107875193A (en) | A kind of pharmaceutical composition for treating calculus and its production and use | |
| CN107913374A (en) | A kind of pharmaceutical composition for treating calculus and preparation method thereof | |
| CN107875308A (en) | A kind of pharmaceutical composition for treating calculus and its production and use | |
| CN107898943A (en) | A kind of pharmaceutical composition for treating calculus and its preparation method and application | |
| CN107812123A (en) | A kind of pharmaceutical composition for treating calculus and its production and use | |
| CN107929400A (en) | A kind of pharmaceutical composition for treating calculus and its preparation method and application | |
| CN107929399A (en) | A kind of pharmaceutical composition for treating calculus and its preparation method and application | |
| CN101502583A (en) | Chinese medicament preparation for treating cholecystitis and gall-stone as well as preparation method thereof | |
| CN108126077A (en) | A kind of pharmaceutical composition for treating fracture or bone split and its preparation method and application | |
| CN108014237A (en) | A kind of pharmaceutical composition for treating bone split or fracture and its preparation method and application | |
| CN108125237A (en) | A kind of anti-inflammatory health products of kobadrin and its preparation process | |
| CN107998252A (en) | It is a kind of to treat fracture or the pharmaceutical composition of bone split and its preparation method and application | |
| CN103816411A (en) | Medicine for treating gallstones and preparation method thereof | |
| CN107812122A (en) | A kind of pharmaceutical composition for treating calculus and preparation method thereof | |
| CN107753800A (en) | A kind of Chinese medicine composition for treating chronic pelvic inflammatory disease and preparation method thereof | |
| CN105902805A (en) | Traditional Chinese medicine for postpartum care | |
| CN108042679A (en) | A kind of pharmaceutical composition for treating fracture or bone split and its preparation method and application | |
| CN105535658A (en) | Traditional Chinese medicine composition for treating dental ulcer and preparation method thereof | |
| CN105477384A (en) | Traditional Chinese medicine composition capable of reducing blood pressure and preparation method of composition | |
| CN108126076A (en) | A kind of pharmaceutical composition for treating fracture or bone split and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180323 |