CN109568437A - A kind of pharmaceutical composition and its preparation method and application for treating infertility - Google Patents
A kind of pharmaceutical composition and its preparation method and application for treating infertility Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
Abstract
The invention discloses a kind of pharmaceutical compositions, it is the preparation being prepared by the raw material of following weight proportion: 15-65 parts of Radix Astragali, 10-50 parts of Radix Codonopsis, 10-50 parts of Radix Angelicae Sinensis, 10-50 parts of Radix Paeoniae Alba, 10-50 parts of Rhizoma Chuanxiong, 10-50 parts of radix rehmanniae preparata, 5-35 parts of Rhizoma Atractylodis Macrocephalae, 5-35 parts of Poria cocos, 1-20 parts of Semen Cuscutae, 1-10 parts of Radix Glycyrrhizae.The present invention also provides the preparation method of the pharmaceutical composition and purposes.Clinical test proves that drug of the present invention can effectively treat infertility, and compatibility is precise and appropriate, curative for effect, has no toxic side effect, and clinical applicability is good, and preparation method is simple, and big technique is suitble to produce.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions for treating infertility.
Background technique
Infertility refers to that all Women of Childbearing Age are lived together 2 years after marriage, and syngamy function is normal, has normal sexuality not practise contraception
And the person that do not become pregnant；Or once bred, it does not practise contraception and 2 years or more the persons that no longer do not become pregnant, the former claims primary infertility, and the latter claims secondary
It is infertile.Cause the complicated multiplicity of the factor of female infertility, mainly by genetic defect, anatomic abnormalities, endocrine disturbance, it is immune because
The a variety of causes such as element, infection, systemic disease and environmental factor cause.In recent years, in world wide in crowd infertility hair
Sick rate has the tendency that rising year by year, and predicts according to the World Health Organization, and in 21 century, infertility, which will become, is only second to tumour and heart and brain
3rd big disease of angiosis.
The drug for the treatment of infertility has hundreds of at present, and Western medicine is mainly based on hormone drug, such as ethinyloestradiol, chromium
Phenol, bromocriptine, progesterone etc..However these drugs, there are biggish toxic side effect, long-term use will bring liver, kidney function to women
The consequences such as energy decline, be easy to cause female irregular menstruation, premature ovarian failure, ovarian hyperstimulation syndrome occur, a few peoples then can
Suffer from ovarian neoplasm.
With the development of the times, scientific and technological, the method for treating infertility is more and more.But in numerous treatment infertilities
Method in, many be all difficult to obtain good curative effect.Traditional Chinese medicine is treating infertile aspect, there is uniqueness,
The effective ingredient of Chinese herbal medicine is the microelement of vegetable protein, animal protein and minerals, later can be different into body
Histocyte selective use, participate in the metabolism of body, cell cycle is regulated and controled, so as to adjust in human body point
Balance is secreted, viscera function is made to restore normal, reproductive organs system physiological function is restored, and can become pregnant raw son naturally.Chinese herbal medicine is root
The prescription according to dialectical, various effective ingredients are combined with required receptor in vivo, open or close corresponding gene expression,
Histocyte is set to restore normal physiological function.So infertile Chinese medicine treatment is effective without any toxic side effect
A kind of method.
Summary of the invention
To achieve the above object, present invention employs following technical solutions:
The present invention provides a kind of pharmaceutical compositions and its preparation method and application for treating infertility.
Pharmaceutical composition provided by the invention is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
15-65 parts of Radix Astragali, 10-50 parts of Radix Codonopsis, 10-50 parts of Radix Angelicae Sinensis, 10-50 parts of Radix Paeoniae Alba, 10-50 parts of Rhizoma Chuanxiong, radix rehmanniae preparata 10-50
Part, 5-35 parts of Rhizoma Atractylodis Macrocephalae, 5-35 parts of Poria cocos, 1-20 parts of Semen Cuscutae, 1-10 parts of Radix Glycyrrhizae.
Further, the pharmaceutical composition is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
30-45 parts of Radix Astragali, 20-35 parts of Radix Codonopsis, 20-35 parts of Radix Angelicae Sinensis, 20-35 parts of Radix Paeoniae Alba, 20-35 parts of Rhizoma Chuanxiong, radix rehmanniae preparata 20-35
Part, 10-25 parts of Rhizoma Atractylodis Macrocephalae, 10-25 parts of Poria cocos, 5-12 parts of Semen Cuscutae, 1-4 parts of Radix Glycyrrhizae.
Further, the pharmaceutical composition is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
40 parts of Radix Astragali, 30 parts of Radix Codonopsis, 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 30 parts of Rhizoma Chuanxiong, 30 parts of radix rehmanniae preparata, 20 parts of Rhizoma Atractylodis Macrocephalae, Poria cocos 20
Part, 10 parts of Semen Cuscutae, 3 parts of Radix Glycyrrhizae.
Wherein, it is to be by the raw material medicinal powder of above-mentioned raw materials medicine, the water extract of bulk pharmaceutical chemicals and/or extractive with organic solvent
Active constituent, along with pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
Pharmaceutically acceptable auxiliary material of the present invention refers in addition to the active ingredient (s include substance in dosage form, packet
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersing agent, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifier, disintegrating agent etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrating agent includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Regulator includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifier includes Tween-80, fatty acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerol etc..
The pharmaceutically acceptable complementary ingredient, it has certain physiological activity, but the addition of the ingredient will not change
Become the leading position of above compound or derivative in the course of disease treatment, and only plays auxiliary effect, these auxiliary function
Effect is only the utilization to the ingredient known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary at
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral preparation.
Preferably, the preparation is decoction, powder, granule, tablet, capsule, oral solution, pill, the pill
The preferably water-bindered pill, honeyed bolus, dripping pill.
The present invention also provides the preparation methods of pharmaceutical composition above-mentioned, it is characterised in that:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) powder is beaten, or water or organic solvent is added to extract, pharmaceutically acceptable auxiliary material is added or complementary ingredient is prepared into
Pharmaceutically common preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition usage mode, after water mentions, since the soluble end of water is wide, and energy
It is enough to dissolve out most of effective component, make drug be easier to be absorbed by the body, works faster, such as the form of medication such as decoction；With
Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of effective component in vivo in medicinal material, but medicinal material is un-extracted,
Effective component still needs to dissolve out re-absorption in vivo, and the opposite water extract that works is slower, but also weaken simultaneously in medicinal material nocuousness at
Divide the toxicity caused by human body, is suitable for taking for a long time, such as original powder is prepared into pill form of medication.At present in pharmacy
In the process, ethyl alcohol extracts drug as solvent and one of most commonly seen extracting mode, ethyl alcohol are that semi-polarity is molten
Agent, solubility property circle can dissolve water-soluble certain ingredients between polarity and nonpolar solvent, and it is molten also to dissolve nonpolarity
Some ingredients of agent dissolution, are usually extracted with ethyl alcohol and replace decocting, to avoid the dissolution of a large amount of invalid components, improve effectively at
The concentration and extraction efficiency divided, but the price of ethyl alcohol is expensive compared with water, in modern pharmaceutical industry mass production, is produced into save
This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to
Various productions and demand when using, can optionally water mentions, original powder, alcohol extracting or their combination method prepare specific agent
Type.
Further, the preparation it is specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or auxiliary is added
Helping property ingredient mixes, granulation, whole grain, it is dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, be added auxiliary material or it is complementary at
Point, granulation, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or auxiliary is added
Helping property ingredient, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting,
Instill in not miscible condensate liquid condensation to get.
The organic solvent is the ethyl alcohol of various concentration, such as the ethyl alcohol of 25%-95%.
The present invention finally additionally provides purposes of the pharmaceutical composition above-mentioned in the drug of preparation treatment infertility.
Radix Astragali is monarch drug in a prescription in pharmaceutical composition of the invention, has effects that tonifying Qi yang-tonifying；Radix Codonopsis, Radix Angelicae Sinensis, white peony root is used as ministerial
Medicine has the effect of enriching the blood and tonifying qi, nourishing blood and liver；Rhizoma Chuanxiong, radix rehmanniae preparata, Rhizoma Atractylodis Macrocephalae, Poria cocos are adjutant, have nourishing YIN for benefiting the kidney, and promoting the circulation of qi is living
The effect of blood, air making-up and spleen enlivening；Semen Cuscutae, Radix Glycyrrhizae are to make medicine, have the effect of nourishing liver and kidney, coordinating the drug actions of a prescription.
Compared with the prior art, the invention has the following beneficial effects: clinical tests to prove, drug energy disclosed by the invention
Effectively treatment infertility, compatibility is precise and appropriate, and each flavour of a drug complement each other, and has no toxic side effect, and has stronger practical application value.
Below by way of the description of specific embodiment, the present invention will be further described, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, within the scope of the present invention.
Specific embodiment
The preparation of the medicinal tablet of the present invention of embodiment 1
Take Radix Astragali 40g, Radix Codonopsis 30g, Radix Angelicae Sinensis 30g, Radix Paeoniae Alba 30g, Rhizoma Chuanxiong 30g, radix rehmanniae preparata 30g, Rhizoma Atractylodis Macrocephalae 20g, Poria cocos 20g, Tu
The sub- 10g of silk, Radix Glycyrrhizae 3g, beat powder, direct powder compression is to get tablet.
The preparation of the medicinal tablet of the present invention of embodiment 2
Take Radix Astragali 30g, Radix Codonopsis 20g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Rhizoma Chuanxiong 20g, radix rehmanniae preparata 20g, Rhizoma Atractylodis Macrocephalae 10g, Poria cocos 10g, Tu
The sub- 5g of silk, Radix Glycyrrhizae 1g, add water to cook extraction, are condensed into medicinal extract, and starch granulation, whole grain, tabletting is added to get tablet.
The preparation of the medicine capsule of the present invention of embodiment 3
Take Radix Astragali 45g, Radix Codonopsis 35g, Radix Angelicae Sinensis 35g, Radix Paeoniae Alba 35g, Rhizoma Chuanxiong 35g, radix rehmanniae preparata 35g, Rhizoma Atractylodis Macrocephalae 25g, Poria cocos 25g, Tu
The sub- 12g of silk, Radix Glycyrrhizae 4g, add water to cook extraction, are condensed into medicinal extract, and auxiliary material is added, and mix, and dispense to get capsule.
The preparation of the drug water-bindered pill of the present invention of embodiment 4
Take Radix Astragali 65g, Radix Codonopsis 50g, Radix Angelicae Sinensis 50g, Radix Paeoniae Alba 50g, Rhizoma Chuanxiong 50g, radix rehmanniae preparata 50g, Rhizoma Atractylodis Macrocephalae 35g, Poria cocos 35g, Tu
The sub- 20g of silk, Radix Glycyrrhizae 10g, beat powder, are sieved, and excipient is added, and water pill is dry to get the water-bindered pill.
The preparation of the drug honeyed bolus of the present invention of embodiment 5
Take Radix Astragali 15g, Radix Codonopsis 10g, Radix Angelicae Sinensis 10g, Radix Paeoniae Alba 10g, Rhizoma Chuanxiong 10g, radix rehmanniae preparata 10g, Rhizoma Atractylodis Macrocephalae 5g, 5g, Tu, Poria cocos
Sub- 1g, Radix Glycyrrhizae 1g, beat powder, sieving, and honey is added, and pill is dry to get honeyed bolus.
The preparation of the drug decoction of the present invention of embodiment 6
Take Radix Astragali 35g, Radix Codonopsis 25g, Radix Angelicae Sinensis 25g, Radix Paeoniae Alba 25g, Rhizoma Chuanxiong 25g, radix rehmanniae preparata 25g, Rhizoma Atractylodis Macrocephalae 15g, Poria cocos 15g, Tu
The sub- 8g of silk, Radix Glycyrrhizae 2g, soak in water decoction, and merging filtrate filters to get decoction.
The preparation of the drug decoction of the present invention of embodiment 7
Take Radix Astragali 20g, Radix Codonopsis 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Rhizoma Chuanxiong 15g, radix rehmanniae preparata 15g, Rhizoma Atractylodis Macrocephalae 10g, Poria cocos 10g, Tu
The sub- 5g of silk, Radix Glycyrrhizae 3g, soak in water decoction, and merging filtrate filters to get decoction.
The preparation of the medicine oral liquid of the present invention of embodiment 8
Take Radix Astragali 50g, Radix Codonopsis 40g, Radix Angelicae Sinensis 40g, Radix Paeoniae Alba 40g, Rhizoma Chuanxiong 40g, radix rehmanniae preparata 40g, Rhizoma Atractylodis Macrocephalae 30g, Poria cocos 30g, Tu
The sub- 18g of silk, Radix Glycyrrhizae 8g soak in water decoction, and merging filtrate, concentration, encapsulating, sterilizing is to get oral solution.
Beneficial effects of the present invention are proved below by way of specific clinical test:
The clinical efficacy of the medicine composite for curing infertility of the present invention of test example 1
1 experimental material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 38, and the age is 29 years old average, course of disease longest 5 years, most 6 months short.
2 experimental methods
2.1 are included in case standard: 1. Women of Childbearing Age has normal sexual life after marriage, and bridegroom's or husband's side reproductive function is normal, does not keep away
Pregnant live together 2 years and fail to become pregnant.2. ovulatory dysfunction is infertile.3. infertile caused by endometriosis.4. fallopian tubal
It is infertile caused by inflammation.5. infertile caused by endometriosis interna.6. infertile caused by Asherman's syndrom.
2.2 exclusion criterias: 1. infertile caused by congenital physiological defect or deformity.2. infertile caused by inherent cause.③
It is infertile etc. caused by immunity.4. bridegroom's or husband's side reproductive function is abnormal.5. it is serious former to be associated with angiocarpy, liver, kidney and hemopoietic system etc.
Hair property disease and mental patient.6. to drug allergy person used.
The judgement of 2.3 curative effects
It is effective: the person of becoming pregnant in 2 years.
It is invalid: without significant change after treatment.
2.4 medication
This medicine daily 3 times, it is early, middle and late respectively take it is primary, each taking when need to be separated with the meal time it is small more than half
When, each taking the weight of drug be equivalent to 3g crude drug, the course for the treatment of: 1-3 months.
3 experimental results
The experiment results show that pharmaceutical composition effective example 36 of the present invention, total effective rate 94.7%, pharmaceutical composition of the present invention
Object can effectively treat infertility, take 1-3 month visible positive effects.
The typical case of the medicine composite for curing infertility of the present invention of test example 2
Case 1: Lee X, 33 years old, multiple post-abortion secondary infertility, a variety of treatments had no effect.This was taken in 2009 afterwards
After medicine 3 months, smoothly it is pregnant and gives birth to a female.
Case 2: Guo XX, 28 years old, 5 years after marriage unpregnancies always were smoothly pregnant after taking within 2001 this medicine 1 month and give birth to one
Son.
To sum up, drug of the present invention can effectively treat infertility, and compatibility is precise and appropriate, curative for effect, have no toxic side effect, and clinic is applicable in
Property good, simple production process, be suitble to big technique to produce.
Claims (9)
1. a kind of pharmaceutical composition, it is characterised in that: it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
15-65 parts of Radix Astragali, 10-50 parts of Radix Codonopsis, 10-50 parts of Radix Angelicae Sinensis, 10-50 parts of Radix Paeoniae Alba, 10-50 parts of Rhizoma Chuanxiong, 10-50 parts of radix rehmanniae preparata,
5-35 parts of Rhizoma Atractylodis Macrocephalae, 5-35 parts of Poria cocos, 1-20 parts of Semen Cuscutae, 1-10 parts of Radix Glycyrrhizae.
2. pharmaceutical composition as described in claim 1, it is characterised in that: it be by following weight proportion bulk pharmaceutical chemicals preparation and
At preparation:
30-45 parts of Radix Astragali, 20-35 parts of Radix Codonopsis, 20-35 parts of Radix Angelicae Sinensis, 20-35 parts of Radix Paeoniae Alba, 20-35 parts of Rhizoma Chuanxiong, 20-35 parts of radix rehmanniae preparata,
10-25 parts of Rhizoma Atractylodis Macrocephalae, 10-25 parts of Poria cocos, 5-12 parts of Semen Cuscutae, 1-4 parts of Radix Glycyrrhizae.
3. pharmaceutical composition as claimed in claim 2, it is characterised in that: it be by following weight proportion bulk pharmaceutical chemicals preparation and
At preparation:
40 parts of Radix Astragali, 30 parts of Radix Codonopsis, 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 30 parts of Rhizoma Chuanxiong, 30 parts of radix rehmanniae preparata, 20 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Poria cocos,
10 parts of Semen Cuscutae, 3 parts of Radix Glycyrrhizae.
4. pharmaceutical composition as claimed in any one of claims 1-3, it is characterised in that: it is by the raw material of above-mentioned raw materials medicine
Medicinal powder, the water extract of bulk pharmaceutical chemicals and/or extractive with organic solvent are active constituent, along with pharmaceutically acceptable auxiliary material or
The complementary ingredient of person is prepared into pharmaceutically common preparation.
5. pharmaceutical composition as claimed in claim 4, it is characterised in that: the preparation is oral preparation.
6. pharmaceutical composition as claimed in claim 5, it is characterised in that: the preparation is decoction, powder, granule, piece
Agent, capsule, oral solution, pill, the pill are preferably the water-bindered pill, honeyed bolus, dripping pill.
7. a kind of method for preparing pharmaceutical composition as claimed in any one of claims 1 to 6, it is characterised in that: including as follows
Step:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) powder is beaten, or water or organic solvent is added to extract, pharmaceutically acceptable auxiliary material is added or complementary ingredient is prepared into pharmacy
Upper common preparation.
8. preparation method as claimed in claim 7, it is characterised in that: it is specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or complementary is added
Ingredient mixes, granulation, whole grain, it is dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and auxiliary material or complementary ingredient, system is added in filtrate concentration
Grain, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or complementary is added
Ingredient, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting, instills
In not miscible condensate liquid condense to get.
9. purposes of the pharmaceutical composition as claimed in any one of claims 1 to 6 in the drug of preparation treatment infertility.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710911995.0A CN109568437A (en) | 2017-09-29 | 2017-09-29 | A kind of pharmaceutical composition and its preparation method and application for treating infertility |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710911995.0A CN109568437A (en) | 2017-09-29 | 2017-09-29 | A kind of pharmaceutical composition and its preparation method and application for treating infertility |
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| Publication Number | Publication Date |
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| CN109568437A true CN109568437A (en) | 2019-04-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710911995.0A Pending CN109568437A (en) | 2017-09-29 | 2017-09-29 | A kind of pharmaceutical composition and its preparation method and application for treating infertility |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546118A (en) * | 2020-12-07 | 2021-03-26 | 上海市第一妇婴保健院 | Traditional Chinese medicine composition for treating diseases caused by repeated embryo planting failure and application thereof |
-
2017
- 2017-09-29 CN CN201710911995.0A patent/CN109568437A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 魏菊仙等: "《中医名方应用进展》", 30 April 1991, 中国医药科技出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546118A (en) * | 2020-12-07 | 2021-03-26 | 上海市第一妇婴保健院 | Traditional Chinese medicine composition for treating diseases caused by repeated embryo planting failure and application thereof |
| CN112546118B (en) * | 2020-12-07 | 2022-04-15 | 上海市第一妇婴保健院 | Traditional Chinese medicine composition for treating diseases caused by repeated embryo planting failure and application thereof |
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