CN109568410A - A kind of pharmaceutical composition and its preparation method and application for treating infertility - Google Patents

A kind of pharmaceutical composition and its preparation method and application for treating infertility Download PDF

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Publication number
CN109568410A
CN109568410A CN201710910961.XA CN201710910961A CN109568410A CN 109568410 A CN109568410 A CN 109568410A CN 201710910961 A CN201710910961 A CN 201710910961A CN 109568410 A CN109568410 A CN 109568410A
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parts
preparation
added
radix
pharmaceutical composition
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郭博信
黄云
沈晓洲
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Traditional Chinese Medicine Science And Technology (beijing) Ltd By Share Ltd Bosin
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Traditional Chinese Medicine Science And Technology (beijing) Ltd By Share Ltd Bosin
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses a kind of pharmaceutical compositions, it is the preparation being prepared by the raw material of following weight proportion: 15-50 parts of Radix Astragali, 15-50 parts of Radix Angelicae Sinensis, 10-45 parts of Rhizoma Chuanxiong, 10-45 parts of teasel root, 5-35 parts of peach kernel, 5-35 parts of safflower, 5-35 parts of pangolin (big gun), 5-35 parts of Rhizoma Atractylodis Macrocephalae, 5-35 parts of Semen Cuscutae, 5-25 parts of Fructus Liquidambaris, 5-25 parts of the fruit of glossy privet, 5-25 parts of radix paeoniae rubra, 1-20 parts of monkshood, 1-15 parts of radix glycyrrhizae preparata.The present invention also provides the preparation method of the pharmaceutical composition and purposes.Clinical test proves that drug of the present invention can effectively treat infertility, and compatibility is precise and appropriate, curative for effect, has no toxic side effect, and clinical applicability is good, and preparation method is simple, and big technique is suitble to produce.

Description

A kind of pharmaceutical composition and its preparation method and application for treating infertility
Technical field
The present invention relates to a kind of pharmaceutical compositions for treating infertility.
Background technique
Infertility refers to that all Women of Childbearing Age are lived together 2 years after marriage, and syngamy function is normal, has normal sexuality not practise contraception And the person that do not become pregnant；Or once bred, it does not practise contraception and 2 years or more the persons that no longer do not become pregnant, the former claims primary infertility, and the latter claims secondary It is infertile.Cause the complicated multiplicity of the factor of female infertility, mainly by genetic defect, anatomic abnormalities, endocrine disturbance, it is immune because The a variety of causes such as element, infection, systemic disease and environmental factor cause.In recent years, in world wide in crowd infertility hair Sick rate has the tendency that rising year by year, and predicts according to the World Health Organization, and in 21 century, infertility, which will become, is only second to tumour and heart and brain 3rd big disease of angiosis.
The drug for the treatment of infertility has hundreds of at present, and Western medicine is mainly based on hormone drug, such as ethinyloestradiol, chromium Phenol, bromocriptine, progesterone etc..However these drugs, there are biggish toxic side effect, long-term use will bring liver, kidney function to women The consequences such as energy decline, be easy to cause female irregular menstruation, premature ovarian failure, ovarian hyperstimulation syndrome occur, a few peoples then can Suffer from ovarian neoplasm.
With the development of the times, scientific and technological, the method for treating infertility is more and more！But in numerous treatment infertilities Method in, many be all difficult to obtain good curative effect.Traditional Chinese medicine is treating infertile aspect, there is uniqueness, The effective ingredient of Chinese herbal medicine is the microelement of vegetable protein, animal protein and minerals, later can be different into body Histocyte selective use, participate in the metabolism of body, cell cycle is regulated and controled, so as to adjust in human body point Balance is secreted, viscera function is made to restore normal, reproductive organs system physiological function is restored, and can become pregnant raw son naturally.Chinese herbal medicine is root The prescription according to dialectical, various effective ingredients are combined with required receptor in vivo, open or close corresponding gene expression, Histocyte is set to restore normal physiological function.So infertile Chinese medicine treatment is effective without any toxic side effect A kind of method.
Summary of the invention
To achieve the above object, present invention employs following technical solutions:
The present invention provides a kind of pharmaceutical compositions and its preparation method and application for treating infertility.
Pharmaceutical composition provided by the invention is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
15-50 parts of Radix Astragali, 15-50 parts of Radix Angelicae Sinensis, 10-45 parts of Rhizoma Chuanxiong, 10-45 parts of teasel root, 5-35 parts of peach kernel, safflower 5-35 Part, 5-35 parts of pangolin (big gun), 5-35 parts of Rhizoma Atractylodis Macrocephalae, 5-35 parts of Semen Cuscutae, 5-25 parts of Fructus Liquidambaris, 5-25 parts of the fruit of glossy privet, radix paeoniae rubra 5- 25 parts, 1-20 parts of monkshood, 1-15 parts of Radix Glycyrrhizae.
Further, the pharmaceutical composition is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
25-40 parts of Radix Astragali, 25-40 parts of Radix Angelicae Sinensis, 20-35 parts of Rhizoma Chuanxiong, 20-35 parts of teasel root, 10-25 parts of peach kernel, safflower 10-25 It is part, 10-25 parts of pangolin (big gun), 10-25 parts of Rhizoma Atractylodis Macrocephalae, 10-25 parts of Semen Cuscutae, 10-17 parts of Fructus Liquidambaris, 10-17 parts of the fruit of glossy privet, red 10-17 parts of Chinese herbaceous peony, 5-12 parts of monkshood, 2-8 parts of Radix Glycyrrhizae.
Further, the pharmaceutical composition is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
35 parts of Radix Astragali, 35 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Chuanxiong, 30 parts of teasel root, 20 parts of peach kernel, 20 parts of safflower, 20 parts of pangolin (big gun), 20 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of Semen Cuscutae, 15 parts of Fructus Liquidambaris, 15 parts of the fruit of glossy privet, 15 parts of radix paeoniae rubra, 10 parts of monkshood, 6 parts of Radix Glycyrrhizae.
Wherein, pangolin is processed product.
Wherein, Radix Glycyrrhizae is radix glycyrrhizae preparata.
Wherein, it is to be by the raw material medicinal powder of above-mentioned raw materials medicine, the water extract of bulk pharmaceutical chemicals and/or extractive with organic solvent Active constituent, along with pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
Pharmaceutically acceptable auxiliary material of the present invention refers in addition to the active ingredient (s include substance in dosage form, packet Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersing agent, wetting agent, adhesive, adjusting Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifier, disintegrating agent etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite, Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second Glycol etc.；Disintegrating agent includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes 0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Regulator includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifier includes Tween-80, fatty acid sorb Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerol etc..
The pharmaceutically acceptable complementary ingredient, it has certain physiological activity, but the addition of the ingredient will not change Become the leading position of above compound or derivative in the course of disease treatment, and only plays auxiliary effect, these auxiliary function Effect is only the utilization to the ingredient known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary at Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral preparation.
Preferably, the preparation is decoction, powder, granule, tablet, capsule, oral solution, pill, the pill The preferably water-bindered pill, honeyed bolus, dripping pill.
The present invention also provides the preparation methods of pharmaceutical composition above-mentioned, it is characterised in that:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) powder is beaten, or water or organic solvent is added to extract, pharmaceutically acceptable auxiliary material is added or complementary ingredient is prepared into Pharmaceutically common preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition usage mode, after water mentions, since the soluble end of water is wide, and energy It is enough to dissolve out most of effective component, make drug be easier to be absorbed by the body, works faster, such as the form of medication such as decoction；With Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of effective component in vivo in medicinal material, but medicinal material is un-extracted, Effective component still needs to dissolve out re-absorption in vivo, and the opposite water extract that works is slower, but also weaken simultaneously in medicinal material nocuousness at Divide the toxicity caused by human body, is suitable for taking for a long time, such as original powder is prepared into pill form of medication.At present in pharmacy In the process, ethyl alcohol extracts drug as solvent and one of most commonly seen extracting mode, ethyl alcohol are that semi-polarity is molten Agent, solubility property circle can dissolve water-soluble certain ingredients between polarity and nonpolar solvent, and it is molten also to dissolve nonpolarity Some ingredients of agent dissolution, are usually extracted with ethyl alcohol and replace decocting, to avoid the dissolution of a large amount of invalid components, improve effectively at The concentration and extraction efficiency divided, but the price of ethyl alcohol is expensive compared with water, in modern pharmaceutical industry mass production, is produced into save This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to Various productions and demand when using, can optionally water mentions, original powder, alcohol extracting or their combination method prepare specific agent Type.
Further, the preparation it is specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or auxiliary is added Helping property ingredient mixes, granulation, whole grain, it is dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, be added auxiliary material or it is complementary at Point, granulation, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or auxiliary is added Helping property ingredient, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting, Instill in not miscible condensate liquid condensation to get.
The organic solvent is the ethyl alcohol of various concentration, such as the ethyl alcohol of 25%-95%.
The present invention finally provides purposes of the pharmaceutical composition above-mentioned in the drug of preparation treatment infertility.
Radix Astragali in pharmaceutical composition of the invention, when being classified as monarch drug in a prescription, replenishing and activating blood, promoting blood circulation for regulating menstruation；Rhizoma Chuanxiong, teasel root, peach kernel, Safflower is ministerial drug, and replenishing and activating blood tonifies the liver and kidney, Stasis through；Pangolin, Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, Fructus Liquidambaris, the fruit of glossy privet, radix paeoniae rubra, Monkshood is adjutant, and warm kidney warms up palace, benefiting kidney-essence, strengthening the spleen and replenishing qi, activating microcirculation and removing stasis medicinal；Radix Glycyrrhizae is to make medicine, is invigorated the spleen and benefited qi all for reconciling Medicine.
Compared with the prior art, the invention has the following beneficial effects: clinical tests to prove, drug energy disclosed by the invention Effectively treatment infertility, compatibility is precise and appropriate, and each flavour of a drug complement each other, and has no toxic side effect, and has stronger practical application value.
Below by way of the description of specific embodiment, the present invention will be further described, but it is to limit of the invention that this, which is not, System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this The basic thought of invention, within the scope of the present invention.
Specific embodiment
The preparation of the medicinal tablet of the present invention of embodiment 1
Take Radix Astragali 35g, Radix Angelicae Sinensis 35g, Rhizoma Chuanxiong 30g, teasel root 30g, peach kernel 20g, safflower 20g, pangolin (big gun) 20g, Rhizoma Atractylodis Macrocephalae 20g, Semen Cuscutae 20g, Fructus Liquidambaris 15g, fruit of glossy privet 15g, radix paeoniae rubra 15g, monkshood 10g, radix glycyrrhizae preparata 6g, beat powder, direct powder compression, Up to tablet.
The preparation of the medicinal tablet of the present invention of embodiment 2
Take Radix Astragali 40g, Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 35g, teasel root 35g, peach kernel 25g, safflower 25g, pangolin (big gun) 25g, Rhizoma Atractylodis Macrocephalae 25g, Semen Cuscutae 25g, Fructus Liquidambaris 17g, fruit of glossy privet 17g, radix paeoniae rubra 17g, monkshood 12g, radix glycyrrhizae preparata 8g add water to cook extraction, concentration At medicinal extract, starch granulation, whole grain, tabletting is added to get tablet.
The preparation of the medicine capsule of the present invention of embodiment 3
Take Radix Astragali 25g, Radix Angelicae Sinensis 25g, Rhizoma Chuanxiong 20g, teasel root 20g, peach kernel 10g, safflower 10g, pangolin (big gun) 10g, Rhizoma Atractylodis Macrocephalae 10g, Semen Cuscutae 10g, Fructus Liquidambaris 10g, fruit of glossy privet 10g, radix paeoniae rubra 10g, monkshood 5g, radix glycyrrhizae preparata 2g add water to cook extraction, are condensed into Auxiliary material is added in medicinal extract, mixes, and dispenses to get capsule.
The preparation of the drug water-bindered pill of the present invention of embodiment 4
Take Radix Astragali 50g, Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 45g, teasel root 45g, peach kernel 35g, safflower 35g, pangolin (big gun) 35g, Rhizoma Atractylodis Macrocephalae 35g, Semen Cuscutae 35g, Fructus Liquidambaris 25g, fruit of glossy privet 25g, radix paeoniae rubra 25g, monkshood 20g, radix glycyrrhizae preparata 15g, beat powder, and sieving is added and assigns Shape agent, water pill are dry to get the water-bindered pill.
The preparation of the drug honeyed bolus of the present invention of embodiment 5
Take Radix Astragali 15g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 10g, teasel root 10g, peach kernel 5g, safflower 5g, pangolin (big gun) 5g, Rhizoma Atractylodis Macrocephalae 5g, Semen Cuscutae 5g, Fructus Liquidambaris 5g, fruit of glossy privet 5g, radix paeoniae rubra 5g, monkshood 1g, radix glycyrrhizae preparata 1g, beat powder, sieving, and honey is added, and pill is done It is dry to get honeyed bolus.
The preparation of the drug decoction of the present invention of embodiment 6
Take Radix Astragali 30g, Radix Angelicae Sinensis 30g, Rhizoma Chuanxiong 25g, teasel root 25g, peach kernel 15g, safflower 15g, pangolin (big gun) 15g, Rhizoma Atractylodis Macrocephalae 15g, Semen Cuscutae 15g, Fructus Liquidambaris 15g, fruit of glossy privet 15g, radix paeoniae rubra 15g, monkshood 10g, radix glycyrrhizae preparata 4g soak in water decoction, merge Filtrate is filtered to get decoction.
The preparation of the drug decoction of the present invention of embodiment 7
Take Radix Astragali 20g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 15g, teasel root 15g, peach kernel 10g, safflower 10g, pangolin (big gun) 10g, Rhizoma Atractylodis Macrocephalae 10g, Semen Cuscutae 10g, Fructus Liquidambaris 10g, fruit of glossy privet 10g, radix paeoniae rubra 10g, monkshood 7g, radix glycyrrhizae preparata 5g soak in water decoction, merge filter Liquid filters to get decoction.
The preparation of the medicine oral liquid of the present invention of embodiment 8
Take Radix Astragali 45g, Radix Angelicae Sinensis 45g, Rhizoma Chuanxiong 40g, teasel root 40g, peach kernel 30g, safflower 30g, pangolin (big gun) 30g, Rhizoma Atractylodis Macrocephalae 30g, Semen Cuscutae 30g, Fructus Liquidambaris 20g, fruit of glossy privet 20g, radix paeoniae rubra 20g, monkshood 15g, radix glycyrrhizae preparata 10g soak in water decoction, merge Filtrate, concentration, encapsulating sterilize to get oral solution.
Beneficial effects of the present invention are proved below by way of specific clinical test:
The clinical efficacy of the medicine composite for curing infertility of the present invention of test example 1
1 experimental material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 35, and the age is 29 years old average, course of disease longest 3 years, most 6 months short.
2 experimental methods
2.1 are included in case standard: 1. Women of Childbearing Age has normal sexual life after marriage, and bridegroom's or husband's side reproductive function is normal, does not keep away Pregnant live together 2 years and fail to become pregnant.2. ovulatory dysfunction is infertile.3. infertile caused by endometriosis.4. fallopian tubal It is infertile caused by inflammation.5. infertile caused by endometriosis interna.6. infertile caused by Asherman's syndrom.
2.2 exclusion criterias: 1. infertile caused by congenital physiological defect or deformity.2. infertile caused by inherent cause.③ It is infertile etc. caused by immunity.4. bridegroom's or husband's side reproductive function is abnormal.5. it is serious former to be associated with angiocarpy, liver, kidney and hemopoietic system etc. Hair property disease and mental patient.6. to drug allergy person used.
The judgement of 2.3 curative effects
It is effective: the person of becoming pregnant in 2 years.
It is invalid: without significant change after treatment.
2.4 medication
This medicine daily 3 times, it is early, middle and late respectively take it is primary, each taking when need to be separated with the meal time it is small more than half When, each taking the weight of drug be equivalent to 3g crude drug, the course for the treatment of: 1-3 months.
3 experimental results
The experiment results show that the effective example of pharmaceutical composition of the present invention is 32, and total effective rate 91.4%, medicine group of the present invention Infertility can effectively be treated by closing object, take 1-3 month visible positive effects.
The typical case of the medicine composite for curing infertility of the present invention of test example 2
Case 1: Wu XX, female, 31 years old.Nearly in delayed period, 5.It gets married 3 years unpregnancies, is diagnosed as premature ovarian failure.Take this medicine 3 It is smoothly pregnant after a month.
Case 2: Tang XX, female, 33 years old.Nearly 20 years dysmenorrhea histories, underbelly panesthesia is ice-cold, and with bearing down, low back is also passed through Often feel to calculate tired.3 years after marriage unpregnancies always are smoothly pregnant after taking this medicine 1 month at the beginning of 2017.
To sum up, drug of the present invention can effectively treat infertility, and compatibility is precise and appropriate, curative for effect, have no toxic side effect, and clinic is applicable in Property good, simple production process, be suitble to big technique to produce.

Claims (10)

1. a kind of pharmaceutical composition, it is characterised in that: it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
15-50 parts of Radix Astragali, 10-45 parts of Rhizoma Chuanxiong, 10-45 parts of teasel root, 5-35 parts of peach kernel, 5-35 parts of safflower, is worn 15-50 parts of Radix Angelicae Sinensis 5-35 parts of naze, 5-35 parts of Rhizoma Atractylodis Macrocephalae, 5-35 parts of Semen Cuscutae, 5-25 parts of Fructus Liquidambaris, 5-25 parts of the fruit of glossy privet, 5-25 parts of radix paeoniae rubra, monkshood 1-20 parts, 1-15 parts of Radix Glycyrrhizae.
2. pharmaceutical composition as described in claim 1, it is characterised in that: it be by following weight proportion bulk pharmaceutical chemicals preparation and At preparation:
25-40 parts of Radix Astragali, 25-40 parts of Radix Angelicae Sinensis, 20-35 parts of Rhizoma Chuanxiong, 20-35 parts of teasel root, 10-25 parts of peach kernel, 10-25 parts of safflower, 10-25 parts of pangolin, 10-25 parts of Rhizoma Atractylodis Macrocephalae, 10-25 parts of Semen Cuscutae, 10-17 parts of Fructus Liquidambaris, 10-17 parts of the fruit of glossy privet, radix paeoniae rubra 10-17 Part, 5-12 parts of monkshood, 2-8 parts of Radix Glycyrrhizae.
3. pharmaceutical composition as claimed in claim 2, it is characterised in that: it be by following weight proportion bulk pharmaceutical chemicals preparation and At preparation:
35 parts of Radix Astragali, 35 parts of Radix Angelicae Sinensis, 30 parts of Rhizoma Chuanxiong, 30 parts of teasel root, 20 parts of peach kernel, 20 parts of safflower, 20 parts of pangolin, Rhizoma Atractylodis Macrocephalae 20 Part, 20 parts of Semen Cuscutae, 15 parts of Fructus Liquidambaris, 15 parts of the fruit of glossy privet, 15 parts of radix paeoniae rubra, 10 parts of monkshood, 6 parts of Radix Glycyrrhizae.
4. pharmaceutical composition as claimed in any one of claims 1-3, it is characterised in that: wherein pangolin is processed product；With/ Or, the Radix Glycyrrhizae is radix glycyrrhizae preparata.
5. the pharmaceutical composition as described in claim 1-4 any one, it is characterised in that: it is by the raw material of above-mentioned raw materials medicine Medicinal powder, the water extract of bulk pharmaceutical chemicals and/or extractive with organic solvent are active constituent, along with pharmaceutically acceptable auxiliary material or The complementary ingredient of person is prepared into pharmaceutically common preparation.
6. pharmaceutical composition as claimed in claim 5, it is characterised in that: the preparation is oral preparation.
7. pharmaceutical composition as claimed in claim 6, it is characterised in that: the preparation is decoction, powder, granule, piece Agent, capsule, oral solution, pill, the pill are preferably the water-bindered pill, honeyed bolus, dripping pill.
8. a kind of method for preparing the pharmaceutical composition as described in claim 1-7 any one, it is characterised in that: including as follows Step:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) powder is beaten, or water or organic solvent is added to extract, pharmaceutically acceptable auxiliary material is added or complementary ingredient is prepared into pharmacy Upper common preparation.
9. preparation method as claimed in claim 8, it is characterised in that: it is specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or complementary is added Ingredient mixes, granulation, whole grain, it is dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and auxiliary material or complementary ingredient, system is added in filtrate concentration Grain, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and filtrate concentration is dry, and auxiliary material or complementary is added Ingredient, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting, instills In not miscible condensate liquid condense to get.
10. purposes of the pharmaceutical composition described in claim 1-7 any one in the drug of preparation treatment infertility.
CN201710910961.XA 2017-09-29 2017-09-29 A kind of pharmaceutical composition and its preparation method and application for treating infertility Pending CN109568410A (en)

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Application Number Priority Date Filing Date Title
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Publications (1)

Publication Number Publication Date
CN109568410A true CN109568410A (en) 2019-04-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Status (1)

Country Link
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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陈玲: "补阳还五汤加味配合微波治疗输卵管阻塞性不孕", 《四川中医》 *

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Application publication date: 20190405