CN109568433A - A kind of pharmaceutical composition and its preparation method and application for treating infertility - Google Patents
A kind of pharmaceutical composition and its preparation method and application for treating infertility Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
Abstract
The invention discloses a kind of pharmaceutical compositions, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: 20-50 parts of Radix Angelicae Sinensis, 20-50 parts of Radix Astragali, 15-45 parts of Rhizoma Chuanxiong, 15-50 parts of RADIX MORINDAE OFFICINALIS, 20-48 parts of teasel root, 20-50 parts of Semen Cuscutae, 5-20 parts of Schisandra chinensis, 1-8 parts of cortex cinnamomi.The present invention also provides the preparation method of the pharmaceutical composition and purposes.Clinical test proves that drug of the present invention effectively treats infertility, and compatibility is precise and appropriate, curative for effect, has no toxic side effect, and clinical applicability is good, and preparation method is simple, and big technique is suitble to produce.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions for treating infertility.
Background technique
Infertility refers to that all Women of Childbearing Age are lived together 2 years after marriage, and syngamy function is normal, has normal sexuality not practise contraception
And the person that do not become pregnant；Or once bred, it does not practise contraception and 2 years or more the persons that no longer do not become pregnant, the former claims primary infertility, and the latter claims secondary
It is infertile.Cause the complicated multiplicity of the factor of female infertility, mainly by genetic defect, anatomic abnormalities, endocrine disturbance, it is immune because
The a variety of causes such as element, infection, systemic disease and environmental factor cause.In recent years, in world wide in crowd infertility hair
Sick rate has the tendency that rising year by year, and predicts according to the World Health Organization, and in 21 century, infertility, which will become, is only second to tumour and heart and brain
3rd big disease of angiosis.
The drug for the treatment of infertility has hundreds of at present, and Western medicine is mainly based on hormone drug, such as ethinyloestradiol, chromium
Phenol, bromocriptine, progesterone etc..However these drugs, there are biggish toxic side effect, long-term use will bring liver, kidney function to women
The consequences such as energy decline, be easy to cause female irregular menstruation, premature ovarian failure, ovarian hyperstimulation syndrome occur, a few peoples then can
Suffer from ovarian neoplasm.
Traditional Chinese medicine theory thinks, the common interpretation of the cause, onset and process of an illness of female sterility has kidney deficiency, liver depression, phlegm wet, blood stasis, qi-blood deficiency
It should be directed to the different interpretation of the cause, onset and process of an illness when Deng, treatment, formulate different treatment methods.Ren Guoxiu etc., " four composite capsule of cornel stilbene cooperation Western medicine is controlled
Treat infertile 43 of Positive Anti-sperm Antibody ", Shaanxi Chinese medicine 3 phases in 2009 disclose four composite capsule of cornel stilbene (pulp of dogwood fruit, Radix Astragali, when
Return, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Sargent gloryvine, Radix Astragali) have the function of that treatment treatment kidney deficiency blood stasis type Positive Anti-sperm Antibody is infertile.Application number:
201210571130.1, denomination of invention: a kind of to adjust menstrual period the Chinese materia medica preparation that breeds is promoted to disclose a kind of infertility for the treatment of
Pharmaceutical composition, it is made of the raw material using following weight proportion: 12 parts of chrysanthemum, 8 parts of Radix Codonopsis, and 12 parts of radix rehmanniae preparata, 8 parts of Radix Angelicae Sinensis,
8 parts of red Radix Paeoniae Alba, 5 parts of Rhizoma Chuanxiong, 8 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Chinese yam, 8 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 8 parts of Poria cocos, 8 parts of Herba Epimedii, 8 parts of Herba Cistanches, Morinda offcinalis How
8 parts of meat, 8 parts of fructus lycii, 8 parts of Semen Cuscutae, 8 parts of raspberry, 8 parts of psoralea corylifolia, 8 parts of the fruit of glossy privet, 8 parts of pulp of dogwood fruit, 8 parts of semen plantaginis,
5 parts of Schisandra chinensis, 8 parts of teasel root, 8 parts of motherwort, patrinia scabiosaefolia Fiscs, 8 parts of cortex albiziae, 3 parts of rose, 5 parts of peach kernel, 5 parts of safflower, Herba Lycopi
5 parts, 5 parts of rhizoma cyperi, 5 parts of radix bupleuri, bosom ox rises 5 parts, 5 parts of excrementum pteropi, 5 parts of cattail pollen, 5 parts of ramulus cinnamomi, 5 parts of cornu cerve degelatinatum, 5 parts of the root bark of tree peony, old
3 parts of skin；This side's prodrug complex, drug cost are high.
It now has no and is used to treat not by the cooperation of Radix Angelicae Sinensis, Radix Astragali, Rhizoma Chuanxiong, RADIX MORINDAE OFFICINALIS, teasel root, Semen Cuscutae, Schisandra chinensis and cortex cinnamomi
The report of pregnant disease.
Summary of the invention
The present invention provides a kind of pharmaceutical composition for treating infertility, and its preparation method and application.
The present invention provides a kind of pharmaceutical compositions, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
20-50 parts of Radix Angelicae Sinensis, 20-50 parts of Radix Astragali, 15-45 parts of Rhizoma Chuanxiong, 15-50 parts of RADIX MORINDAE OFFICINALIS, 20-48 parts of teasel root, 20-50 parts of Semen Cuscutae,
5-20 parts of Schisandra chinensis, 1-8 parts of cortex cinnamomi.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: 25-40 parts of Radix Angelicae Sinensis, Radix Astragali 25-45
Part, 20-35 parts of Rhizoma Chuanxiong, 20-35 parts of RADIX MORINDAE OFFICINALIS, 25-40 parts of teasel root, 25-45 parts of Semen Cuscutae, 8-18 parts of Schisandra chinensis, cortex cinnamomi 2-6
Part.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Astragali, Rhizoma Chuanxiong
30 parts, 30 parts of RADIX MORINDAE OFFICINALIS, 30 parts of teasel root, 30 parts of Semen Cuscutae, 10 parts of Schisandra chinensis, 3 parts of cortex cinnamomi.
Wherein, the RADIX MORINDAE OFFICINALIS is the dry root of madder wort Morinda officinalis Morinda officinalis How.
Wherein, the composition is with Radix Angelicae Sinensis, Radix Astragali, Rhizoma Chuanxiong, RADIX MORINDAE OFFICINALIS, teasel root, Semen Cuscutae, Schisandra chinensis and the medicine of cortex cinnamomi
Powder or water or extractive with organic solvent are effective component, in addition the preparation that pharmaceutically acceptable auxiliary material is prepared.
Pharmaceutically acceptable auxiliary material of the present invention refers in addition to the active ingredient (s include substance in dosage form, packet
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersing agent, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifier, disintegrating agent etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrating agent includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Regulator includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifier includes Tween-80, fatty acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerol etc..
The pharmaceutically acceptable complementary ingredient, it has certain physiological activity, but the addition of the ingredient will not change
Become the leading position of above compound or derivative in the course of disease treatment, and only plays auxiliary effect, these auxiliary function
Effect is only the utilization to the ingredient known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary at
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral preparation.
Wherein, the preparation is powder, decoction, granule, tablet, capsule, oral solution, pill；Preferably, the ball
Agent is the water-bindered pill, honeyed bolus, dripping pill.
The present invention also provides the preparation methods of pharmaceutical composition above-mentioned, it is characterised in that:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration adds
Pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition usage mode, after water mentions, since the soluble end of water is wide, and energy
It is enough to dissolve out most of effective component, make drug be easier to be absorbed by the body, works faster, such as the form of medication such as decoction；With
Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of effective component in vivo in medicinal material, but medicinal material is un-extracted,
Effective component still needs to dissolve out re-absorption in vivo, and the opposite water extract that works is slower, but also weaken simultaneously in medicinal material nocuousness at
Divide the toxicity caused by human body, is suitable for taking for a long time, such as original powder is prepared into pill form of medication.At present in pharmacy
In the process, ethyl alcohol extracts drug as solvent and one of most commonly seen extracting mode, ethyl alcohol are that semi-polarity is molten
Agent, solubility property circle can dissolve water-soluble certain ingredients between polarity and nonpolar solvent, and it is molten also to dissolve nonpolarity
Some ingredients of agent dissolution, are usually extracted with ethyl alcohol and replace decocting, to avoid the dissolution of a large amount of invalid components, improve effectively at
The concentration and extraction efficiency divided, but the price of ethyl alcohol is expensive compared with water, in modern pharmaceutical industry mass production, is produced into save
This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to
Various productions and demand when using, can optionally water mentions, original powder, alcohol extracting or their combination method prepare specific agent
Type.
Wherein, specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, dry, addition auxiliary material or auxiliary
Helping property ingredient, mix, granulation, whole grain, dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, be added auxiliary material or it is complementary at
Point, granulation, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, and filtering, filtrate is concentrated and dried, and auxiliary material or auxiliary is added
Property ingredient, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting,
Instill in not miscible condensate liquid condensation to get.
The organic solvent is the ethyl alcohol of various concentration, such as the ethyl alcohol of 25%-95%.
The present invention finally extracts purposes of the pharmaceutical composition above-mentioned in the drug of preparation treatment infertility.
In pharmaceutical composition of the present invention, Radix Angelicae Sinensis, Radix Astragali are monarch, qi-blood tonifying, promoting blood circulation for regulating menstruation；Rhizoma Chuanxiong, RADIX MORINDAE OFFICINALIS are ministerial drug,
Kidney-replenishing, strengthening the bones and muscles, wind-dispelling, warm palace, promoting blood circulation, promoting the circulation of qi；Teasel root, Semen Cuscutae, Schisandra chinensis, cortex cinnamomi are that assistant makes, and draw all efficacy of a drug downlinks
Warm palace, kidney tonifying, controlling nocturnal emission with astringent drugs.The prescription medicine collective effect, nourishing liver and kidney, vital energy regualting and blood circulation-promoting, nourishing blood for regulating menstruation.
Clinical test proves that drug disclosed by the invention can effectively treat infertility, and compatibility is precise and appropriate, each flavour of a drug Xiang Fuxiang
At, have no toxic side effect, have stronger practical application value.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
The preparation of the medicinal tablet of the present invention of embodiment 1
Take Radix Angelicae Sinensis 30g, Radix Astragali 30g, Rhizoma Chuanxiong 30g, RADIX MORINDAE OFFICINALIS 30g, teasel root 30g, Semen Cuscutae 30g, Schisandra chinensis 10g, cortex cinnamomi
3g beats powder, and direct powder compression is to get tablet.The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis Morinda
The dry root of officinalis How.
The preparation of the medicinal tablet of the present invention of embodiment 2
Take Radix Angelicae Sinensis 25g, Radix Astragali 25g, Rhizoma Chuanxiong 20g, RADIX MORINDAE OFFICINALIS 20g, teasel root 25g, Semen Cuscutae 25g, Schisandra chinensis 8g, cortex cinnamomi
2g adds water to cook extraction, is condensed into medicinal extract, and starch granulation, whole grain, tabletting is added to get tablet.The RADIX MORINDAE OFFICINALIS is madder
The dry root of section plant Morinda officinalis Morinda officinalis How.
The preparation of the medicine capsule of the present invention of embodiment 3
Take Radix Angelicae Sinensis 40g, Radix Astragali 45g, Rhizoma Chuanxiong 35g, RADIX MORINDAE OFFICINALIS 35g, teasel root 40g, Semen Cuscutae 45g, Schisandra chinensis 18g, cortex cinnamomi
6g adds water to cook extraction, is condensed into medicinal extract, and auxiliary material is added, and mixes, and dispenses to get capsule.The RADIX MORINDAE OFFICINALIS is Rubiaceae
The dry root of plant Morinda officinalis Morinda officinalis How.
The preparation of the drug water-bindered pill of the present invention of embodiment 4
Take Radix Angelicae Sinensis 20g, Radix Astragali 20g, Rhizoma Chuanxiong 15g, RADIX MORINDAE OFFICINALIS 15g, teasel root 20g, Semen Cuscutae 20g, Schisandra chinensis 5g, cortex cinnamomi
1g beats powder, sieving, and excipient is added, and water pill is dry to get the water-bindered pill.The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis
The dry root of Morinda officinalis How.
The preparation of the drug honeyed bolus of the present invention of embodiment 5
Take Radix Angelicae Sinensis 50g, Radix Astragali 50g, Rhizoma Chuanxiong 45g, RADIX MORINDAE OFFICINALIS 50g, teasel root 48g, Semen Cuscutae 50g Schisandra chinensis 20g, cortex cinnamomi
8g beats powder, sieving, and honey is added, and pill is dry to get honeyed bolus.The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis
The dry root of Morinda officinalis How.
The preparation of the drug decoction of the present invention of embodiment 6
Take Radix Angelicae Sinensis 30g, Radix Astragali 30g, Rhizoma Chuanxiong 30g, RADIX MORINDAE OFFICINALIS 30g, teasel root 30g, Semen Cuscutae 30g, Schisandra chinensis 10g, cortex cinnamomi
3g；Decoction is soaked in water, merging filtrate filters to get decoction.The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis Morinda
The dry root of officinalis How.
The preparation of the drug decoction of the present invention of embodiment 7
Take Radix Angelicae Sinensis 50g, Radix Astragali 50g, Rhizoma Chuanxiong 45g, RADIX MORINDAE OFFICINALIS 50g, teasel root 48g, Semen Cuscutae 50g Schisandra chinensis 20g, cortex cinnamomi
8g；Decoction is soaked in water, merging filtrate filters to get decoction.The RADIX MORINDAE OFFICINALIS is madder wort Morinda officinalis Morinda
The dry root of officinalis How.
The preparation of the medicine oral liquid of the present invention of embodiment 8
Take Radix Angelicae Sinensis 30g, Radix Astragali 30g, Rhizoma Chuanxiong 30g, RADIX MORINDAE OFFICINALIS 30g, teasel root 30g, Semen Cuscutae 30g, Schisandra chinensis 10g, cortex cinnamomi
3g；Decoction is soaked in water, merging filtrate, concentration, encapsulating, sterilizing is to get oral solution.The RADIX MORINDAE OFFICINALIS is madder wort bar
The dry root of halberd day Morinda officinalis How.
Beneficial effects of the present invention are proved below by way of specific clinical test:
The clinical efficacy of the medicine composite for curing infertility of the present invention of test example 1
1 experimental material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 45, and the age is 26 years old average.
2 experimental methods
2.1 are included in case standard: 1. Women of Childbearing Age has normal sexual life after marriage, and bridegroom's or husband's side reproductive function is normal, does not keep away
Pregnant live together 2 years and fail to become pregnant.2. ovulatory dysfunction is infertile.3. infertile caused by endometriosis.4. fallopian tubal
It is infertile caused by inflammation.5. infertile caused by endometriosis interna.6. infertile caused by Asherman's syndrom.
2.2 exclusion criterias: 1. infertile caused by congenital physiological defect or deformity.2. infertile caused by inherent cause.③
It is infertile etc. caused by immunity.4. bridegroom's or husband's side reproductive function is abnormal.5. it is serious former to be associated with angiocarpy, liver, kidney and hemopoietic system etc.
Hair property disease and mental patient.6. to drug allergy person used.
The judgement of 2.3 curative effects
It is effective: the person of becoming pregnant in 2 years.
It is invalid: without significant change after treatment.
2.4 medication
This medicine daily 3 times, it is early, middle and late respectively take it is primary, each taking when need to be separated with the meal time it is small more than half
When, each taking the weight of drug be equivalent to 3 grams of crude drugs.
3 experimental results
Experimental result: taking 1-3 month visible positive effects, and pharmaceutical composition effective 43 of the present invention, total effective rate
95.6%, pharmaceutical composition of the present invention can effectively treat infertility.
The typical case of the medicine composite for curing infertility of the present invention of test example 2
Case 1: all XX, female, 30 years old.Ovarian cyst has been found in May, 2007 patient's physical examination, is cured mainly after operation excision big
Husband informs that adnexal adhesions are very serious, and bladder is sticked together with ovary, and also adhesion is serious for fallopian tubal, unless doing oviduct dredging
Operation, otherwise can not be pregnant at all.Physical examination in 2008 is found again has grown new ovarian cyst, and is apprised of in this case
99.9% cannot be pregnant.In September, 2008 takes this medicine, one girl baby of the natural labor of in September, 2009.In May, 2010 patient's physical examination again, inspection
The fruit ovarian cyst that comes to an end disappears.
Case 2: poplar XX, female, 29 years old.Beginning standby pregnant in 2009, but because failing to be pregnant always with adnexal cyst.2011
It takes this medicine within 2 months, pregnancy in April.
To sum up, drug of the present invention can effectively treat infertility, and compatibility is precise and appropriate, curative for effect, have no toxic side effect, and clinic is applicable in
Property good, simple production process, be suitble to big technique to produce.
Claims (10)
1. a kind of pharmaceutical composition, it is characterised in that: it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: Radix Angelicae Sinensis
20-50 parts, 20-50 parts of Radix Astragali, 15-45 parts of Rhizoma Chuanxiong, 15-50 parts of RADIX MORINDAE OFFICINALIS, 20-48 parts of teasel root, 20-50 parts of Semen Cuscutae, the five tastes
It is 5-20 parts sub-, 1-8 parts of cortex cinnamomi.
2. pharmaceutical composition according to claim 1, it is characterised in that: it is the bulk pharmaceutical chemicals preparation by following weight proportion
Made of preparation: 25-40 parts of Radix Angelicae Sinensis, 25-45 parts of Radix Astragali, 20-35 parts of Rhizoma Chuanxiong, 20-35 parts of RADIX MORINDAE OFFICINALIS, 25-40 parts, Tu of teasel root
25-45 parts sub-, 8-18 parts of Schisandra chinensis, 2-6 parts of cortex cinnamomi.
3. pharmaceutical composition according to claim 2, it is characterised in that: it is the bulk pharmaceutical chemicals preparation by following weight proportion
Made of preparation: 30 parts of Radix Angelicae Sinensis, 30 parts of Radix Astragali, 30 parts of Rhizoma Chuanxiong, 30 parts of RADIX MORINDAE OFFICINALIS, 30 parts of teasel root, 30 parts of Semen Cuscutae, Schisandra chinensis 10
Part, 3 parts of cortex cinnamomi.
4. pharmaceutical composition according to claim 1 to 3, it is characterised in that: the RADIX MORINDAE OFFICINALIS is Rubiaceae
The dry root of plant Morinda officinalis Morinda officinalis How.
5. pharmaceutical composition according to any one of claims 1-4, it is characterised in that: the composition be with Radix Angelicae Sinensis,
Radix Astragali, Rhizoma Chuanxiong, RADIX MORINDAE OFFICINALIS, teasel root, Semen Cuscutae, Schisandra chinensis and the medicinal powder of cortex cinnamomi or water or extractive with organic solvent are effective
Ingredient, in addition pharmaceutically acceptable auxiliary material is prepared into pharmaceutically common preparation.
6. pharmaceutical composition according to claim 5, it is characterised in that: the preparation is oral preparation.
7. pharmaceutical composition according to claim 6, it is characterised in that: the preparation is powder, decoction, granule, piece
Agent, capsule, oral solution, pill；Preferably, the pill is the water-bindered pill, honeyed bolus, dripping pill.
8. the preparation method of pharmaceutical composition described in claim 1-7 any one, it is characterised in that:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration adds pharmacy
Upper acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
9. preparation method according to claim 8, it is characterised in that: it is specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, dry, addition auxiliary material or complementary
Ingredient, mix, granulation, whole grain, dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and auxiliary material or complementary ingredient, system is added in filtrate concentration
Grain, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, and filtering, filtrate is concentrated and dried, be added auxiliary material or it is complementary at
Point, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting, instills
In not miscible condensate liquid condense to get.
10. purposes of the pharmaceutical composition described in claim 1-7 any one in the drug of preparation treatment infertility.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476861A (en) * | 2002-08-21 | 2004-02-25 | 伊剑华 | Chinese Medicine preparation for curing female sterility |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476861A (en) * | 2002-08-21 | 2004-02-25 | 伊剑华 | Chinese Medicine preparation for curing female sterility |
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