CN109568436A - A kind of pharmaceutical composition and its preparation method and application for treating infertility - Google Patents
A kind of pharmaceutical composition and its preparation method and application for treating infertility Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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Abstract
The invention discloses a kind of pharmaceutical compositions, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: 20-50 parts of Radix Angelicae Sinensis, 25-45 parts of Radix Paeoniae Alba, 15-45 parts of Radix Codonopsis, 20-45 parts of Rhizoma Chuanxiong, 15-40 parts of motherwort, 10-40 parts of radix rehmanniae preparata, 10-35 parts interrupted, 5-20 parts of Cortex Eucommiae, 2-8 parts of Radix Glycyrrhizae.The present invention also provides the preparation method of the pharmaceutical composition and purposes.Clinical test proves that drug of the present invention effectively treats infertility, and compatibility is precise and appropriate, curative for effect, has no toxic side effect, and clinical applicability is good, and preparation method is simple, and big technique is suitble to produce.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions for treating infertility.
Background technique
Infertility refers to that all Women of Childbearing Age are lived together 2 years after marriage, and syngamy function is normal, has normal sexuality not practise contraception
And the person that do not become pregnant；Or once bred, it does not practise contraception and 2 years or more the persons that no longer do not become pregnant, the former claims primary infertility, and the latter claims secondary
It is infertile.Cause the complicated multiplicity of the factor of female infertility, mainly by genetic defect, anatomic abnormalities, endocrine disturbance, it is immune because
The a variety of causes such as element, infection, systemic disease and environmental factor cause.In recent years, in world wide in crowd infertility hair
Sick rate has the tendency that rising year by year, and predicts according to the World Health Organization, and in 21 century, infertility, which will become, is only second to tumour and heart and brain
3rd big disease of angiosis.
The drug for the treatment of infertility has hundreds of at present, and Western medicine is mainly based on hormone drug, such as ethinyloestradiol, chromium
Phenol, bromocriptine, progesterone etc..However these drugs, there are biggish toxic side effect, long-term use will bring liver, kidney function to women
The consequences such as energy decline, be easy to cause female irregular menstruation, premature ovarian failure, ovarian hyperstimulation syndrome occur, a few peoples then can
Suffer from ovarian neoplasm.
Traditional Chinese medicine theory thinks, the common interpretation of the cause, onset and process of an illness of female sterility has kidney deficiency, liver depression, phlegm wet, blood stasis, qi-blood deficiency
It should be directed to the different interpretation of the cause, onset and process of an illness when Deng, treatment, formulate different treatment methods.Ren Guoxiu etc., " four composite capsule of cornel stilbene cooperation Western medicine is controlled
Treat infertile 43 of Positive Anti-sperm Antibody ", Shaanxi Chinese medicine 3 phases in 2009 disclose four composite capsule of cornel stilbene (pulp of dogwood fruit, Radix Astragali, when
Return, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Sargent gloryvine, radix scutellariae) have the function of that treatment treatment kidney deficiency blood stasis type Positive Anti-sperm Antibody is infertile.Application number:
200710054734.8, denomination of invention: the Chinese materia medica preparation for treating female infertility discloses a kind of medicine group for treating infertility
It closes, it is made of the raw material using following weight proportion: 45 parts of Radix Codonopsis, 40 parts of Rhizoma Atractylodis Macrocephalae, 40 parts of Yun Ling, 35 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis
45 parts, 45 parts of Rhizoma Chuanxiong, 35 parts of Radix Paeoniae Alba, 45 parts of radix rehmanniae preparata, 45 parts of Cortex Eucommiae, 55 parts of radix dipsaci, 45 parts of Morinda officinalis, 45 parts of herba taxilli, radix aucklandiae
35 parts, 45 parts of the root bark of tree peony, 45 parts of motherwort, 40 parts of safflower, 35 parts of rhizoma cyperi, 45 parts of radix bupleuri, 40 parts of Radix Curcumae, 35 parts of the tuber of pinellia, dried orange peel 45
Part, 35 parts of western fennel, 35 parts of donkey-hide gelatin；This side's prodrug complex, drug cost are high.
It now has no and is used to treat not by Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Codonopsis, Rhizoma Chuanxiong, motherwort, radix rehmanniae preparata, interrupted, Cortex Eucommiae and Radix Glycyrrhizae cooperation
The report of pregnant disease.
Summary of the invention
The present invention provides a kind of pharmaceutical composition for treating infertility, and its preparation method and application.
The present invention provides a kind of pharmaceutical compositions, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion:
20-50 parts of Radix Angelicae Sinensis, 15-45 parts of Radix Codonopsis, 20-45 parts of Rhizoma Chuanxiong, 15-40 parts of motherwort, 10-40 parts of radix rehmanniae preparata, breaks at 25-45 parts of Radix Paeoniae Alba
Continue 10-35 parts, 5-20 parts of Cortex Eucommiae, 2-8 parts of Radix Glycyrrhizae.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: 25-40 parts of Radix Angelicae Sinensis, Radix Paeoniae Alba 30-40
Part, 20-35 parts of Radix Codonopsis, 25-40 parts of Rhizoma Chuanxiong, 20-35 parts of motherwort, 15-35 parts of radix rehmanniae preparata, 15-30 parts interrupted, 8-15 parts of Cortex Eucommiae,
4-7 parts of Radix Glycyrrhizae.
Wherein, it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: 35 parts of Radix Angelicae Sinensis, 35 parts of Radix Paeoniae Alba, Radix Codonopsis
30 parts, 30 parts of Rhizoma Chuanxiong, 30 parts of motherwort, 30 parts of radix rehmanniae preparata, 20 parts interrupted, 10 parts of Cortex Eucommiae, 6 parts of Radix Glycyrrhizae.
Wherein, the composition is with Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Codonopsis, Rhizoma Chuanxiong, motherwort, radix rehmanniae preparata, interrupted, Cortex Eucommiae and Radix Glycyrrhizae
Medicinal powder or water or extractive with organic solvent are effective component, in addition the preparation that pharmaceutically acceptable auxiliary material is prepared.
Pharmaceutically acceptable auxiliary material of the present invention refers in addition to the active ingredient (s include substance in dosage form, packet
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersing agent, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifier, disintegrating agent etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrating agent includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Regulator includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including sodium dihydrogen phosphate and disodium hydrogen phosphate) etc.；Emulsifier includes Tween-80, fatty acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerol etc..
The pharmaceutically acceptable complementary ingredient, it has certain physiological activity, but the addition of the ingredient will not change
Become the leading position of above compound or derivative in the course of disease treatment, and only plays auxiliary effect, these auxiliary function
Effect is only the utilization to the ingredient known activity, is the usual adjuvant treatment modality of field of medicaments.If by it is above-mentioned it is complementary at
Divide and be used cooperatively with the compounds of this invention, still should belong to the scope of protection of the invention.
Wherein, the preparation is oral preparation.
Wherein, the preparation is powder, decoction, granule, tablet, capsule, oral solution, pill；Preferably, described
Pill is the water-bindered pill, honeyed bolus, dripping pill.
The present invention also provides the preparation methods of pharmaceutical composition above-mentioned, it is characterised in that:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration adds
Pharmaceutically acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
Water extract is used as medicine with medicinal powder, is Chinese medicine tradition usage mode, after water mentions, since the soluble end of water is wide, and energy
It is enough to dissolve out most of effective component, make drug be easier to be absorbed by the body, works faster, such as the form of medication such as decoction；With
Original powder is used as medicine, and the surface area of medicinal powder is larger, is also beneficial to the absorption of effective component in vivo in medicinal material, but medicinal material is un-extracted,
Effective component still needs to dissolve out re-absorption in vivo, and the opposite water extract that works is slower, but also weaken simultaneously in medicinal material nocuousness at
Divide the toxicity caused by human body, is suitable for taking for a long time, such as original powder is prepared into pill form of medication.At present in pharmacy
In the process, ethyl alcohol extracts drug as solvent and one of most commonly seen extracting mode, ethyl alcohol are that semi-polarity is molten
Agent, solubility property circle can dissolve water-soluble certain ingredients between polarity and nonpolar solvent, and it is molten also to dissolve nonpolarity
Some ingredients of agent dissolution, are usually extracted with ethyl alcohol and replace decocting, to avoid the dissolution of a large amount of invalid components, improve effectively at
The concentration and extraction efficiency divided, but the price of ethyl alcohol is expensive compared with water, in modern pharmaceutical industry mass production, is produced into save
This, usually or based on decocting.In the case where the water extract of known compositions of the present invention has physiological activity, in order to adapt to
Various productions and demand when using, can optionally water mentions, original powder, alcohol extracting or their combination method prepare specific agent
Type.
Wherein, specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, dry, addition auxiliary material or auxiliary
Helping property ingredient, mix, granulation, whole grain, dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, be added auxiliary material or it is complementary at
Point, granulation, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, and filtering, filtrate is concentrated and dried, and auxiliary material or auxiliary is added
Property ingredient, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting,
Instill in not miscible condensate liquid condensation to get.
The organic solvent is the ethyl alcohol of various concentration, such as the ethyl alcohol of 25%-95%.
The present invention finally extracts purposes of the pharmaceutical composition above-mentioned in the drug of preparation treatment infertility.
In pharmaceutical composition of the present invention, Radix Angelicae Sinensis, Radix Paeoniae Alba are monarch, replenishing and activating blood, nourishing blood and liver, menstruction regulating and pain relieving；Radix Codonopsis, river
Rhizome of chuanxiong, motherwort are ministerial drug, and QI invigorating is promoted the production of body fluid, and activating microcirculation and removing stasis medicinal dredges the channels；Radix rehmanniae preparata, interrupted, Cortex Eucommiae, Radix Glycyrrhizae are that assistant makes, and tonifying Qi is mended
Liver kidney, life essence-filling, marrow-benefitting adjust punching to appoint, strengthening the bones and muscles, promoting circulation of blood arteries and veins.The prescription medicine collective effect, nourishing liver and kidney, vital energy regualting and blood circulation-promoting, replenishing essence benefit
Marrow, nourishing blood for regulating menstruation.
Clinical test proves that drug disclosed by the invention can effectively treat infertility, and compatibility is precise and appropriate, each flavour of a drug Xiang Fuxiang
At, have no toxic side effect, have stronger practical application value.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
The preparation of the medicinal tablet of the present invention of embodiment 1
Take Radix Angelicae Sinensis 35g, Radix Paeoniae Alba 35g, Radix Codonopsis 30g, Rhizoma Chuanxiong 30g, motherwort 30g, radix rehmanniae preparata 30g, interrupted 20g, Cortex Eucommiae 10g,
Radix Glycyrrhizae 6g beats powder, and direct powder compression is to get tablet.
The preparation of the medicinal tablet of the present invention of embodiment 2
Take Radix Angelicae Sinensis 25g, Radix Paeoniae Alba 30g, Radix Codonopsis 20g, Rhizoma Chuanxiong 25g, motherwort 20g, radix rehmanniae preparata 15g, interrupted 15g, Cortex Eucommiae 8g, sweet
Careless 4g adds water to cook extraction, is condensed into medicinal extract, and starch granulation, whole grain, tabletting is added to get tablet.
The preparation of the medicine capsule of the present invention of embodiment 3
Take Radix Angelicae Sinensis 40g, Radix Paeoniae Alba 40g, Radix Codonopsis 35g, Rhizoma Chuanxiong 40g, motherwort 35g, radix rehmanniae preparata 35g, interrupted 30g, Cortex Eucommiae 15g,
Radix Glycyrrhizae 7g adds water to cook extraction, is condensed into medicinal extract, and auxiliary material is added, and mixes, and dispenses to get capsule.
The preparation of the drug water-bindered pill of the present invention of embodiment 4
Take Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 25g, Radix Codonopsis 15g, Rhizoma Chuanxiong 20g, motherwort 15g, radix rehmanniae preparata 10g, interrupted 10g, Cortex Eucommiae 5g, sweet
Careless 2g beats powder, sieving, and excipient is added, and water pill is dry to get the water-bindered pill.
The preparation of the drug honeyed bolus of the present invention of embodiment 5
Take Radix Angelicae Sinensis 50g, Radix Paeoniae Alba 45g, Radix Codonopsis 45g, Rhizoma Chuanxiong 45g, motherwort 40g, radix rehmanniae preparata 40g, interrupted 35g, Cortex Eucommiae 20g,
Radix Glycyrrhizae 8g beats powder, sieving, and honey is added, and pill is dry to get honeyed bolus.
The preparation of the drug decoction of the present invention of embodiment 6
Take Radix Angelicae Sinensis 50g, Radix Paeoniae Alba 45g, Radix Codonopsis 45g, Rhizoma Chuanxiong 45g, motherwort 40g, radix rehmanniae preparata 40g, interrupted 35g, Cortex Eucommiae 20g,
Radix Glycyrrhizae 8g；Decoction is soaked in water, merging filtrate filters to get decoction.
The preparation of the drug decoction of the present invention of embodiment 7
Take Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 25g, Radix Codonopsis 15g, Rhizoma Chuanxiong 20g, motherwort 15g, radix rehmanniae preparata 10g, interrupted 10g, Cortex Eucommiae 5g, sweet
Careless 2g；Decoction is soaked in water, merging filtrate filters to get decoction.
The preparation of the medicine oral liquid of the present invention of embodiment 8
Take Radix Angelicae Sinensis 35g, Radix Paeoniae Alba 35g, Radix Codonopsis 30g, Rhizoma Chuanxiong 30g, motherwort 30g, radix rehmanniae preparata 30g, interrupted 20g, Cortex Eucommiae 10g,
Radix Glycyrrhizae 6g；Decoction is soaked in water, merging filtrate, concentration, encapsulating, sterilizing is to get oral solution.
Beneficial effects of the present invention are proved below by way of specific clinical test:
The clinical efficacy of the medicine composite for curing infertility of the present invention of test example 1
1 experimental material
1.1 experimental drugs pharmaceutical composition of the present invention, is prepared by embodiment 1.
1.2 patient datas observe case totally 35, and the age is 31 years old average.
2 experimental methods
2.1 are included in case standard: 1. Women of Childbearing Age has normal sexual life after marriage, and bridegroom's or husband's side reproductive function is normal, does not keep away
Pregnant live together 2 years and fail to become pregnant.2. ovulatory dysfunction is infertile.3. infertile caused by endometriosis.4. fallopian tubal
It is infertile caused by obstruction, salpingitis.5. infertile caused by endometriosis interna.6. infertile caused by Asherman's syndrom.
2.2 exclusion criterias: 1. infertile caused by congenital physiological defect or deformity.2. infertile caused by inherent cause.③
It is infertile etc. caused by immunity.4. bridegroom's or husband's side reproductive function is abnormal.5. it is serious former to be associated with angiocarpy, liver, kidney and hemopoietic system etc.
Hair property disease and mental patient.6. to drug allergy person used.
The judgement of 2.3 curative effects
It is effective: the person of becoming pregnant in 2 years.
It is invalid: without significant change after treatment.
2.4 medication
This medicine daily 3 times, it is early, middle and late respectively take it is primary, each taking when need to be separated with the meal time it is small more than half
When, each taking the weight of drug be equivalent to 3 grams of crude drugs.
3 experimental results
The experiment results show that 1-3 month visible positive effects are taken, it is pharmaceutical composition effective 34 of the present invention, total effective
Rate 97%, pharmaceutical composition of the present invention can effectively treat infertility.
The typical case of the medicine composite for curing infertility of the present invention of test example 2
Case 1: golden XX, female 32 years old, get married 8 years with husband, want child always and be not pregnant, hospital does not also check
What problem out is smoothly pregnant after taking this medicine 3 months within 14 years.
Case 2: thanking to X, and female 38 years old, once produced a female, several years latter oviductus lateralis excision, and other side salpingemphraxis is thought
It wants two tires but trial has no resolution for a long time, be smoothly pregnant after taking this medicine 3 months.
Case 3: X, female, 39 years old, ovulatory dysfunction was smoothly pregnant after taking this product 1 month.
To sum up, drug of the present invention can effectively treat infertility, and compatibility is precise and appropriate, curative for effect, have no toxic side effect, and clinic is applicable in
Property good, simple production process, be suitble to big technique to produce.
Claims (9)
1. a kind of pharmaceutical composition, it is characterised in that: it is the preparation being prepared by the bulk pharmaceutical chemicals of following weight proportion: Radix Angelicae Sinensis
20-50 parts, 25-45 parts of Radix Paeoniae Alba, 15-45 parts of Radix Codonopsis, 20-45 parts of Rhizoma Chuanxiong, 15-40 parts of motherwort, 10-40 parts of radix rehmanniae preparata, interrupted 10-
35 parts, 5-20 parts of Cortex Eucommiae, 2-8 parts of Radix Glycyrrhizae.
2. pharmaceutical composition according to claim 1, it is characterised in that: it is the bulk pharmaceutical chemicals preparation by following weight proportion
Made of preparation: 25-40 parts of Radix Angelicae Sinensis, 30-40 parts of Radix Paeoniae Alba, 20-35 parts of Radix Codonopsis, 25-40 parts of Rhizoma Chuanxiong, 20-35 parts of motherwort, radix rehmanniae preparata
15-35 parts, 15-30 parts interrupted, 8-15 parts of Cortex Eucommiae, 4-7 parts of Radix Glycyrrhizae.
3. pharmaceutical composition according to claim 2, it is characterised in that: it is the bulk pharmaceutical chemicals preparation by following weight proportion
Made of preparation: 35 parts of Radix Angelicae Sinensis, 35 parts of Radix Paeoniae Alba, 30 parts of Radix Codonopsis, 30 parts of Rhizoma Chuanxiong, 30 parts of motherwort, 30 parts of radix rehmanniae preparata, it is 20 parts interrupted,
10 parts of Cortex Eucommiae, 6 parts of Radix Glycyrrhizae.
4. pharmaceutical composition according to claim 1 to 3, it is characterised in that: the composition be with Radix Angelicae Sinensis,
Radix Paeoniae Alba, Radix Codonopsis, Rhizoma Chuanxiong, motherwort, radix rehmanniae preparata, discontinuously, the medicinal powder or water or extractive with organic solvent of Cortex Eucommiae and Radix Glycyrrhizae be effective
Ingredient, in addition pharmaceutically acceptable auxiliary material is prepared into pharmaceutically common preparation.
5. pharmaceutical composition according to claim 4, it is characterised in that: the preparation is oral preparation.
6. pharmaceutical composition according to claim 5, it is characterised in that: the preparation is powder, decoction, granule, piece
Agent, capsule, oral solution, pill；Preferably, the pill is the water-bindered pill, honeyed bolus, dripping pill.
7. the preparation method of pharmaceutical composition as claimed in any one of claims 1 to 6, it is characterised in that:
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) bulk pharmaceutical chemicals directly beat powder, or bulk pharmaceutical chemicals are added water to cook or organic solvent extracts, and extracting solution concentration adds pharmacy
Upper acceptable auxiliary material or complementary ingredient are prepared into pharmaceutically common preparation.
8. preparation method according to claim 7, it is characterised in that: it is specific the preparation method is as follows:
Decoction: weighing bulk pharmaceutical chemicals, decoct, filtering to get；
Powder: weighing bulk pharmaceutical chemicals, beats powder, sieving to get；
Granule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, filtrate concentration, dry, addition auxiliary material or complementary
Ingredient, mix, granulation, whole grain, dry to get；
Tablet: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and auxiliary material or complementary ingredient, system is added in filtrate concentration
Grain, whole grain, tabletting to get；
Capsule: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, and filtering, filtrate is concentrated and dried, be added auxiliary material or it is complementary at
Point, mix, it is encapsulated to get；
The water-bindered pill: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added excipient, water pill, it is dry to get；
Honeyed bolus: weighing bulk pharmaceutical chemicals, beats powder, sieving, is added honey, pill, it is dry to get；
Dripping pill: weighing bulk pharmaceutical chemicals, and water or organic solvent is added to extract, filtering, and matrix is added in filtrate, mixes heating and melting, instills
In not miscible condensate liquid condense to get.
9. purposes of the pharmaceutical composition as claimed in any one of claims 1 to 6 in the drug of preparation treatment infertility.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983818A (en) * | 2015-07-29 | 2015-10-21 | 王洪安 | Traditional Chinese medicine for treating gynecologic diseases, and preparation method thereof |
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2017
- 2017-09-29 CN CN201710911132.3A patent/CN109568436A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983818A (en) * | 2015-07-29 | 2015-10-21 | 王洪安 | Traditional Chinese medicine for treating gynecologic diseases, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 范正祥: "《家庭用药百事问》", 31 January 2004, 中国人口出版社 * |
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