CN101279031A - Chinese medicinal composition for curing hyperthyroidism and method of preparing the same - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for curing graves, which is prepared by tambac, chrysoidine, scorpion, stiff silkworm, woodlouse, airpotato yam rhizome, rhubarb, pariphyllin, angelica, wolfberry fruit, taraxacum, plaster stone, anemarrhena, magnolia bark, white paeony root, angelica, alum, alisma orientale and/or a vector which is acceptable in pharmacy. The invention also relates to a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition of the invention has the functions of removing heat from the liver and purging pathogenic fire, softening hard lumps and dispelling nodes, replenishing qi and keeping yang, dispersing the depressed liver-energy, relieving depression, etc. and is used for curing the diseases caused by hyperthyroidism, such as palpitation, tachycardia, heat fearing, dermatorrhea, polyphagia and marasmus, lassitude, etc.

Description

A kind of Chinese medicine composition for the treatment of hyperthyroidism and preparation method thereof

Technical field:

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of hyperthyroidism and preparation method thereof.

Background technology

" hyperthyroidism " is meant the caused one group of clinical syndrome of parathyroid tissue hypertrophy, hyperfunctioning, generation and secretion first shape hormonosis, is hyperthyroidism, is called for short hyperthyroidism.

Hyperthyroidism can divide scorching five types:

1.Graves sick nodular thyroid goiter accompanied with thyroid hyperthyroidism (many nodositas toxic goiter).

2. autonomous hyperactive adenoma (Plummer disease).

3. iodine hyperthyroidism.

4. hypophysis hyperthyroidism.

5.HCG dependency hyperthyroidism.

Wherein, the Graves hyperthyroidism is the most common, accounts for 85% of all hyperthyroidisms.

Hyperthyroid patient mainly shows as: nervous, tachycardia, To Be Protected from Heat, hyperhidrosis, polyphagia and become thin (people's polyphagia also being arranged but obesity), fatigue and weak and emotion is emotional, irascible temperament, insomnia, absent-minded, exophthalmos, hands tremor of the tongue are trembled, goiter or enlargement, amyotrophy and chronic hyperthyroidism myopathy, myasthenia can be arranged.The women can have menoxenia even amenorrhea, and the male can have sexual impotence or breast development etc.Hyperthyroidism can cause that also the low potassium of part patient benumbs all over the body, (the Asia male patient is comparatively common) its mainly to show as lower limb tingle unable, whole body muscular soreness.Thyromegaly is symmetry, and the patient who also has is the asymmetry enlargement, and goiter or enlargement meeting move up and down along with swallowing, and also some hyperthyroid patient has thyroid nodule.The eye that causes during hyperthyroidism changes, and a class is a benign exophthalmos, patient's exophthalmos, eye gaze or present terrified expression in the eyes; Another kind is a malignant exophthalmos, can change by benign exophthalmos and form, malignant exophthalmos patient Chang You keeps in dark place, aversion to wind, shed tears, diplopia, visual deterioration, eye swell and ache, twinge, foreign body sensation etc. is arranged, because the eyeball height is outstanding, make eyes closure fully, conjunctiva, cornea expose and cause that hyperemia, edema, cornea fester etc., even blind.The hyperthyroid patient that yet has does not have eye symptom or symptom not obvious.Above-mentioned all is clinical manifestations of typical hyperthyroidism, but is not that every hyperthyroidism is suffered from all clinical symptoms and had, and dissimilar hyperthyroidisms, clinical manifestation are also different.

Hyperthyroidism disease is not healed for a long time, a series of complication can occur, and as hyperthyroid heart disease, hyperthyroidism limb paralysis, hyperthyroidism hypertension, hyperthyroidism diabetes, hyperthyroidism psychosis etc., the person of being in a bad way can cause hyperthyroidism crisis, but rescues not anxious crisis life often.

Hyperthyroidism crisis is the acute deterioration of the hyperthyroidism disease moment of desperation, causes general metabolism seriously disorderly, function serious hindrances such as cardiovascular system, digestive system, nervous system, and normal threat to life, untimely as diagnosis and emergency measures, mortality rate is high.Even diagnoses and treatment is timely, about 5～15% patient also is difficult to escape death by sheer luck.

The occurring principle of primary disease still imperfectly understands so far, does not obtain medical treatment or under the still unsteered situation of treatment in hyperthyroidism often, meets some stressors and causes the generation of hyperthyroidism crisis.Stress situation under, the synthetic a large amount of thyroxins of thyroid also are released into blood with it, original hyperthyroidism disease moment of desperation play is increased the weight of, and the vigor of catecholamine is obviously strengthened, and further increase the weight of the state of an illness.

The traditional Chinese medical science thinks that hyperthyroidism belongs to " goiter " category, claims wart, goiter, wart capsule, shadow bands again.The traditional Chinese medical science thinks that the cause of disease of primary disease and feelings will and body constitution have confidential relation, because secular spirit depressing or suffer violent psychic trauma suddenly, the catharsis malfunction that all can cause liver, depression of liver-QI, the stagnation of QI and can not move body fluid, the body fluid cohesion forms expectorant, with the passing of time mental disorder fights knot, QI-blood circulation is obstructed, qi depression to blood stasis, phlegm and blood stasis, the then swollen hardening of wart, state of an illness day is heavy.Hepatic depression fire-transformation of a specified duration, liver-fire is vigorous, and last tap holder order is then seen being irritable and getting angry easily, and face is warmed, and bitter taste in the mouth and dry throat is had a dizzy spell, diseases such as wiry and frequent pulse.Fire is contained and is easy to consume the liquid impairment of YIN, the stomach-Yin of burning, and the cloudy then heat of hindering, heat is rapid digestion of food and polyorexia then.Liver-yang hyperactivity is violated spleen, dysfunction of the spleen in transportation, and see the loose stool, become thin fatigue and weakness.Fire is contained and is disturbed the heart, and the heart-yin is lost empty, and malaise is then seen severe palpitation, dysphoria and insomnia, diseases such as hyperhidrosis thready and rapid pulse.Blood stored in the liver links to each other with chong channel, chong channel master menstruation, stagnation of QI due to depression of the liver, then woman's menoxenia, infrequent menstruation or amenorrhea.Deficiency of kidney yin, the kidney failing to nourish the liver, so that deficiency of the yin of the liver, excessive rising of liver-YANG, liver-wind stirring up internally is then seen the hands tremor linguae.Hepatic and renal YIN deficiency, hyperactivity of the ministerial fire, disturbing the essence-chamber, then man's seminal emission, even sexual impotence.The deficiency of YIN is then given birth to interior-heat, thus see that To Be Protected from Heat, low grade fever, red tongue is red, thready and rapid pulse etc.Or the factor body deficiency of YIN, meet the stagnation of QI, very easily fire-transformation is vigorous on the liver-fire, easy again impairment of YIN.Thereby producing above-mentioned pathological change is difficult for recovering.Be under the jurisdiction of liver because of dashing to appoint again, the woman grows, and gestation is all relevant with the Liver Channel QI and blood on physiology between age of sucking, and this moment is if the QI and blood of Liver Channel is in case imbalance then very easily causes pathological changes such as the stagnation of QI, liver-fire or qi depression to blood stasis.Because of the deficiency of both vital energy and Yin in puerperal, if stagnated fire arranged, also easy impairment of YIN, thus primary disease clinically Chang Yiqing, middle aged women for seeing more.How real this onset of disease is, and pathological factor has the stagnation of QI, liver-fire, expectorant to coagulate and blood stasis, and the stagnation of QI is earlier; Prolonged illness belongs to empty, and based on the deficiency of YIN, and that pathological change relates to liver, kidney, the heart, spleen etc. is dirty.Traditional Chinese medical science employing purging liver-fire, hard masses softening and resolving, QI invigorating are established the yang function, this disease of decoction for the treatment of dispersing the stagnated live-QI to relieve the stagnation of QI.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of hyperthyroidism.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of hyperthyroidism, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

The tangerine 20-30 part of Lignum Aquilariae Resinatum 10-15 part Scorpio 5-10 part

Bombyx Batryticatus 5-10 part Eupolyphaga Seu Steleophaga 15-20 part Rhizoma Dioscoreae Bulbiferae 20-30 part

Radix Et Rhizoma Rhei 15-25 part Rhizoma Paridis 5-10 part Radix Angelicae Sinensis 25-35 part

Fructus Lycii 20-30 part Herba Taraxaci 10-20 part Gypsum Fibrosum 20-25 part

Rhizoma Anemarrhenae 15-20 part Cortex Magnoliae Officinalis 10-20 part Radix Paeoniae Alba 15-25 part

Rhizoma Et Radix Notopterygii 10-15 part Alumen 5-10 part Rhizoma Alismatis 10-20 part

Effective ingredient is preferably made by weight by following raw materials according:

8 parts of 26 portions of Scorpios of 13 parts of dried tangerine peels of Lignum Aquilariae Resinatum

26 parts of 18 parts of Rhizoma Dioscoreae Bulbiferaes of 8 parts of Eupolyphaga Seu Steleophagas of Bombyx Batryticatus

30 parts of 8 parts of Radix Angelicae Sinensis of 21 parts of Rhizoma Paridis of Radix Et Rhizoma Rhei

23 parts of 16 parts of Gypsum Fibrosum of 26 parts of Herba Taraxacis of Fructus Lycii

21 parts of 15 portions of Radix Paeoniae Albas of 18 parts of Cortex Magnoliae Officinalis of the Rhizoma Anemarrhenae

16 parts of 8 portions of Rhizoma Alismatis of 13 parts of Alumen of Rhizoma Et Radix Notopterygii

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) Gypsum Fibrosum, that alum powder is broken into impalpable powder is standby;

(2) Lignum Aquilariae Resinatum, Radix Angelicae Sinensis, Herba Taraxaci are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) dried tangerine peel, Scorpio, Bombyx Batryticatus, Eupolyphaga Seu Steleophaga, Rhizoma Dioscoreae Bulbiferae, Radix Et Rhizoma Rhei, Rhizoma Paridis, Fructus Lycii, the Rhizoma Anemarrhenae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Rhizoma Alismatis decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Chinese medicine composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has effects such as purging liver-fire, hard masses softening and resolving, QI invigorating are established the yang function, dispersing the stagnated live-QI to relieve the stagnation of QI, nervous, the tachycardia that is used for that hyperthyroidism causes, To Be Protected from Heat, hyperhidrosis, polyphagia and become thin, disease such as fatigue and weak.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) Gypsum Fibrosum 230g, that Alumen 80g is ground into impalpable powder is standby;

(2) Lignum Aquilariae Resinatum 130g, Radix Angelicae Sinensis 300g, Herba Taraxaci 160g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) tangerine 260g, Scorpio 80g, Bombyx Batryticatus 80g, Eupolyphaga Seu Steleophaga 180g, Rhizoma Dioscoreae Bulbiferae 260g, Radix Et Rhizoma Rhei 210g, Rhizoma Paridis 80g, Fructus Lycii 260g, Rhizoma Anemarrhenae 180g, Cortex Magnoliae Officinalis 150g, Radix Paeoniae Alba 210g, Rhizoma Et Radix Notopterygii 130g, Rhizoma Alismatis 160g decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule with pharmaceutically acceptable carrier.

Embodiment 2: the agent of invention Chinese medicinal composition capsules

(1) Gypsum Fibrosum 230g, that Alumen 80g is ground into impalpable powder is standby;

(2) Lignum Aquilariae Resinatum 130g, Radix Angelicae Sinensis 300g, Herba Taraxaci 160g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) tangerine 260g, Scorpio 80g, Bombyx Batryticatus 80g, Eupolyphaga Seu Steleophaga 180g, Rhizoma Dioscoreae Bulbiferae 260g, Radix Et Rhizoma Rhei 210g, Rhizoma Paridis 80g, Fructus Lycii 260g, Rhizoma Anemarrhenae 180g, Cortex Magnoliae Officinalis 150g, Radix Paeoniae Alba 210g, Rhizoma Et Radix Notopterygii 130g, Rhizoma Alismatis 160g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: invention Chinese medicine composition tablet

(1) Gypsum Fibrosum 230g, that Alumen 80g is ground into impalpable powder is standby;

(2) Lignum Aquilariae Resinatum 130g, Radix Angelicae Sinensis 300g, Herba Taraxaci 160g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) tangerine 260g, Scorpio 80g, Bombyx Batryticatus 80g, Eupolyphaga Seu Steleophaga 180g, Rhizoma Dioscoreae Bulbiferae 260g, Radix Et Rhizoma Rhei 210g, Rhizoma Paridis 80g, Fructus Lycii 260g, Rhizoma Anemarrhenae 180g, Cortex Magnoliae Officinalis 150g, Radix Paeoniae Alba 210g, Rhizoma Et Radix Notopterygii 130g, Rhizoma Alismatis 160g decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add starch 300g, microcrystalline Cellulose 50g and carboxymethylstach sodium 50g mixing, sieve, with 70% ethanol wet granulation, tabletting, coating are promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of hyperthyroidism is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

The tangerine 20-30 part of Lignum Aquilariae Resinatum 10-15 part Scorpio 5-10 part

Bombyx Batryticatus 5-10 part Eupolyphaga Seu Steleophaga 15-20 part Rhizoma Dioscoreae Bulbiferae 20-30 part

Radix Et Rhizoma Rhei 15-25 part Rhizoma Paridis 5-10 part Radix Angelicae Sinensis 25-35 part

Fructus Lycii 20-30 part Herba Taraxaci 10-20 part Gypsum Fibrosum 20-25 part

Rhizoma Anemarrhenae 15-20 part Cortex Magnoliae Officinalis 10-20 part Radix Paeoniae Alba 15-25 part

Rhizoma Et Radix Notopterygii 10-15 part Alumen 5-10 part Rhizoma Alismatis 10-20 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

8 parts of 26 portions of Scorpios of 13 parts of dried tangerine peels of Lignum Aquilariae Resinatum

26 parts of 18 parts of Rhizoma Dioscoreae Bulbiferaes of 8 parts of Eupolyphaga Seu Steleophagas of Bombyx Batryticatus

30 parts of 8 parts of Radix Angelicae Sinensis of 21 parts of Rhizoma Paridis of Radix Et Rhizoma Rhei

23 parts of 16 parts of Gypsum Fibrosum of 26 parts of Herba Taraxacis of Fructus Lycii

21 parts of 15 portions of Radix Paeoniae Albas of 18 parts of Cortex Magnoliae Officinalis of the Rhizoma Anemarrhenae

16 parts of 8 portions of Rhizoma Alismatis of 13 parts of Alumen of Rhizoma Et Radix Notopterygii.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) Gypsum Fibrosum, that alum powder is broken into impalpable powder is standby;

(2) Lignum Aquilariae Resinatum, Radix Angelicae Sinensis, Herba Taraxaci are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) dried tangerine peel, Scorpio, Bombyx Batryticatus, Eupolyphaga Seu Steleophaga, Rhizoma Dioscoreae Bulbiferae, Radix Et Rhizoma Rhei, Rhizoma Paridis, Fructus Lycii, the Rhizoma Anemarrhenae, Cortex Magnoliae Officinalis, the Radix Paeoniae Alba, Rhizoma Et Radix Notopterygii, Rhizoma Alismatis decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.