CN109045210A - A kind of Chinese medicine composition and preparation method thereof for treating cardiovascular and cerebrovascular disease - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating cardiovascular and cerebrovascular disease Download PDFInfo
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Abstract
The embodiment of the invention discloses a kind of for treating the Chinese medicine composition of cardiovascular and cerebrovascular disease, is prepared from the following raw materials in parts by weight: 20-45 parts of rhizome of chuanxiong, 25-50 parts of Radix Salviae Miltiorrhizae, 10-25 parts of west safflower, 10-25 parts of pueraria lobata, 15-30 parts of radix paeoniae rubra, 15-30 parts of dalbergia wood, 5-15 parts of leech, 5-15 parts of Eupolyphoge sinensis, 5-15 parts of corydalis tuber, 5-20 parts of Rhizoma Gastrodiae.The embodiment of the invention also discloses a kind of for treating the preparation method and application of the Chinese medicine composition of cardiovascular and cerebrovascular disease.Chinese medicine composition disclosed by the invention has effects that recuperating qi-blood, vital energy regualting and blood circulation-promoting, clearing and activating the channels and collaterals, activating microcirculation and removing stasis medicinal, can be effectively improved patient clinical symptom, has good curative effect to cardiovascular and cerebrovascular disease, safety is without side-effects, and does not recur.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating cardiovascular and cerebrovascular disease and
Preparation method.
Background technique
With the change of life style and eating habit, cardiovascular and cerebrovascular disease such as hypertension, hyperlipidemia, coronary heart disease etc. is at me
The disease incidence of state increases year by year, have become extremely threaten human health disease, after especially 45 years old (on) the elderly very
To being a middle-aged person, this three probability of the death rate, disability rate and illness rate are all very high, disease of the annual whole world because of cardiovascular and cerebrovascular
Mortality is apparently higher than other kinds of disease.The disease of cardiovascular and cerebrovascular includes heart and the two kinds of disease of the cerebrovascular,
The reason of generally falling ill is: hypertension, hyperlipemia, artery are athero- and it is too sticky to harden (atherosclerosis), blood,
Each tissue of heart organ and brain even body is caused all to cause the disease of ischemic or Bleeding pattern for these reasons.
It clinically there is no good specific aim radical cure scheme at present, mainly based on symptomatic treatment.Although 50% or more suffers from
Person can survive, but its quality of life is severely impacted.
Traditional Chinese medicine is with a long history in the prevention and treatment of cardiovascular and cerebrovascular diseases, and there have simplicity, safety, low toxicity, Small side effects etc. to be excellent
Gesture.But existing Chinese medicine haves the defects that raw material components are more and uncertain therapeutic efficacy is cut.
In view of this, the present invention is specifically proposed.
Summary of the invention
Of the existing technology in order to solve the problems, such as, being designed to provide for the embodiment of the present invention is a kind of for treating heart and brain
Chinese medicine composition of vascular diseases and preparation method thereof.
To achieve the above object, the first aspect of the embodiment of the present invention provides a kind of for treating cardiovascular and cerebrovascular disease
Chinese medicine composition, the Chinese medicine composition are prepared from the following raw materials in parts by weight: 20-45 parts of rhizome of chuanxiong, 25-50 parts of Radix Salviae Miltiorrhizae, west
10-25 parts of safflower, 10-25 parts of pueraria lobata, 15-30 parts of radix paeoniae rubra, 15-30 parts of dalbergia wood, 5-15 parts of leech, 5-15 parts of Eupolyphoge sinensis, corydalis tuber 5-
15 parts, 5-20 parts of Rhizoma Gastrodiae.
Further, the Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-40 parts of rhizome of chuanxiong, Radix Salviae Miltiorrhizae 25-35
Part, 10-20 parts of west safflower, 15-25 parts of pueraria lobata, 18-25 parts of radix paeoniae rubra, 15-25 parts of dalbergia wood, 8-15 parts of leech, 5-12 parts of Eupolyphoge sinensis, member
5-15 parts of Hu, 5-10 parts of Rhizoma Gastrodiae.
Further, the Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 parts of rhizome of chuanxiong, 30 parts of Radix Salviae Miltiorrhizae, west
18 parts of safflower, 18 parts of pueraria lobata, 20 parts of radix paeoniae rubra, 20 parts of dalbergia wood, 10 parts of leech, 10 parts of Eupolyphoge sinensis, 10 parts of corydalis tuber, 8 parts of Rhizoma Gastrodiae.
Further, the Chinese medicine composition is using the water extract of raw material or raw material as active constituent, in addition pharmaceutically may be used
Preparation is made in the carrier or diluent of receiving.
Further, the preparation is any one of capsule, tablet, granule, pill, paste, decoction.
The second aspect of the embodiment of the present invention provides the above-mentioned Chinese medicine composition for treating cardiovascular and cerebrovascular disease
Preparation method, the method are as follows:
Each raw material for weighing corresponding parts by weight, being ground into partial size after mixing is 80-120 mesh powder.
The third aspect of the embodiment of the present invention provides the above-mentioned Chinese medicine composition for treating cardiovascular and cerebrovascular disease
Preparation method the described method comprises the following steps:
1) each raw material for weighing corresponding parts by weight, is ground into coarse powder after mixing；
2) 10-15 times of the raw material gross weight water measured is added in above-mentioned coarse powder, decocts 1-2h, filtration is added in filter residue
6-8 times of the raw material gross weight water measured decocts 0.5-1h, filtration, and decocting liquid merging twice staticly settles 12-24 hours, takes supernatant,
Relative density is the lotion of 1.1-1.3 when being concentrated under reduced pressure into 60 DEG C.
The fourth aspect of the embodiment of the present invention provides above-mentioned Chinese medicine composition in preparation for treating cardiovascular and cerebrovascular disease
Application in the drug of disease.
The effect of each raw material in the present invention, is described below:
Rhizome of chuanxiong: for the rhizome of Umbelliferae herbaceous plant Rhizoma Chuanxiong.It is acrid in flavour and warm in nature.Return liver, gallbladder, pericardium channel.With promoting blood circulation, dispel
The functions such as wind analgesic and promote breath and open depression.Containing the phenolic substances such as alkaloid, ferulic acid and chuanxingol, Diligustilide, ligustrazine,
Trimethylamine hydrochloride, choline hydrochloride etc..Ligustrazine energy coronary artery dilator increases coronary blood flow, improves the blood oxygen of cardiac muscle
Supply, and reduce the oxygen demand of cardiac muscle；The expansible cerebrovascular of ligustrazine reduces vascular resistence, dramatically increases brain and limb blood flow
Amount improves microcirculation；Surface activity of blood platelet can be reduced, platelet aggregation, the formation of pre- preventing thrombosis are inhibited；Contained ferulic acid
Neutral component low dose promotes, and large dosage inhibits uterine smooth muscle；Water decoction has sedation to animal central nervous systems, and
There is obvious and lasting antihypertensive effect；It can accelerate the absorption of fracture local hematoma, poroma is promoted to be formed；There is antivitamin E shortage
Effect；It can inhibit a variety of bacillus；There are antihistaminicum and choleretic effect.
Radix Salviae Miltiorrhizae: for the dry root and rhizome of Lamiaceae plant Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Hardship, it is slightly cold；Return
The heart, pericardium, Liver Channel.With promoting blood circulation for regulating menstruation, the effect of stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness is calmed the nerves.Cure mainly irregular menstruation, amenorrhoea
Dysmenorrhea, postpartum stasis abdominal pain, blood stasis is pained, epigastric pain , lumps in the chest and abdomen, traumatic injury, rheumatism bi Zheng, sore and toxic, pyreticosis
Irritated coma, palpitation and insomnia.
West safflower: for the drying column cap of irides safron CrocussativusL.Introduce cultivar.Existing Beijing,
There is cultivation on the ground such as Shandong, Zhejiang, Sichuan.It is sweet in flavor, it is mild-natured.Converge to heart and liver channels.With activating microcirculation and removing stasis medicinal, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization
Effect.For menostasis abdominal mass, postpartum stasis, febrile virulent maculae, melancholy ruffian is bored, and palpitation with fear is gone mad.
Pueraria lobata: for the dry root of legume pueraria lobata.It is sweet, pungent, it is cool；Returns spleen, stomach meridian.It brings down a fever with expelling pathogenic factors from muscles and skin, promoting eruption is promoted the production of body fluid
Quench the thirst, Shengyang Zhixie effect.Exterior syndrome fever is cured mainly, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat expels the heat-evil dysentery,
Splenasthenic diarrhea.
Radix paeoniae rubra: for the dry root of ranunculaceae plant radix paeoniae rubra or river radix paeoniae rubra.Hardship, it is slightly cold；Return liver warp has clearing heat and cooling blood, promoting blood circulation
The effect of dissolving stasis.Cure mainly febrile virulent maculae, blood-head tells nosebleed, red eye, swell pain, carbuncle swells sore, liver-depressed hypochondrium pain, amenorrhea and algomenorrhea , Disorder lump in the abdomen abdomen
Bitterly, traumatic injury.
Dalbergia wood: for the dry duramen of leguminous plant dalbergia wood wingceltis DalbergiaodoriferaT.Chen trunk and root.It is pungent,
Temperature；Return liver, the spleen channel.With removing blood stasis and hemostasis, the effect of regulating qi-flowing for relieving pain.Blood trouble is cured mainly out, pain in chest and hypochondrium falls damage stasis caused pain, vomits abdomen
Bitterly.
Leech: for Hirudinidae animal whitmania Whitm.aniaPigraWhitman, leech
HirudonipponicaWhitman's or willow leaf leech WhitmaniaacranutataWhitman is dry all.It is salty, bitter,
It is flat；Return liver warp.With blood-breaking promoting menstruation, the effect of by stagnation resolvation disease.Cure mainly blood stasis , lumps in the chest and abdomen, traumatic injury, trusted subordinate's pain
Bitterly.
Eupolyphoge sinensis: also known as eupolyphoge sinensis, belong to insect, body is flat, brownish black, and male has wing, and female is aptery.Chinese medicine Eupolyphoge sinensis is eupolyphoge sinensis
The female adult of Lian section eupolyphagasinensis walker (Eupolyphagasinensis Walker) or polyphagaplancyi (Steleophaga plancyi) is dry
Dry body after capture, is set in boiling water and is scalded extremely, dry or dry.It is salty, it trembles with fear.It is slightly poisonous.With promoting blood circulation to remove blood stasis, inducing meastruation to relieve menalgia effect.
The major functions: traumatic injury, extravasated blood swelling and pain, amenorrhoea, postpartum blood stasis abdominal pain.
Corydalis tuber: also known as rhizoma corydalis, it is Papaveraceae Corydalis herbaceos perennial, corydalis tuber is concluded in Compendium of Material Medica to be had
" promoting blood circulation, sharp gas, analgesic, diuresis " 4 large effects, and praise highly corydalis tuber " can the stagnation of the circulation of vital energy in promoting circulation of blood, stasis in gas, therefore specially control with one
Under all pains ".It is pungent, bitter, temperature.Enter liver, spleen, the heart channel of Hang-Shaoyin.With promoting blood circulation, sharp gas, the effect only led to.
Rhizoma Gastrodiae: also known as Rhizoma Gastrodiae, from mother, yellow moccasin flower, god grass, solely shake sesame, rhizoma gastrodiae rouge, wind grass, conjunction and shaken, automatically from grass, solely
Grass, water potato.For the dry tuber of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Gan Ping, return liver warp.There is anti-epileptic, resists
Throb with fear and faints, antirheumatic；The effect of calmness, antispastic, analgesia, qi-restoratives, suppressing hyperactive liver for calming endogenous wind.Major function suppressing hyperactive liver for calming endogenous wind relieving convulsion.For having a headache
Dizziness, extremity numbness, epilepsy clonus, tetanus.It feels dizzy, neurasthenia, wind-cold-dampness arthralgia, the diseases such as child convulsion.Clinic is answered
With proof, there is significant curative effect to vascular nervous headache, postconcussion syndrome etc..
Cardiovascular and cerebrovascular disease is common clinical disease, causes to seriously affect to the life of patient as a kind of chronic disease,
Its case fatality rate and disability rate are higher, need to be pocessed and control in time.As long as doctor trained in Western medicine for cardiovascular and cerebrovascular disease treatment with
Anticoagulant, reduction intracranial pressure, expansion blood vessel and dehydration etc. are suited the medicine to the illness based on supportive treatment, effective for the control effect of disease.Heart and brain
Vascular diseases belong to the scopes such as " apoplexy ", " dizziness " in Chinese medicine, and tcm theory thinks that the cause of disease of cardiovascular and cerebrovascular disease is drink
Eat qi-blood deficiency, qi depression to blood stasis, deficiency of liver-yin and kidney-yin caused by imbalance, inadequate natural endowment, ailment said due to cold or exposure invasion, over fatigue etc. etc..
The embodiment of the present invention has the advantages that
1, Chinese medicine composition disclosed by the invention with rhizome of chuanxiong, Radix Salviae Miltiorrhizae, west safflower, pueraria lobata, radix paeoniae rubra, dalbergia wood, leech, Eupolyphoge sinensis,
Corydalis tuber, Rhizoma Gastrodiae are raw material, are with rhizome of chuanxiong promoting blood circulation, Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, west safflower removing pattogenic heat from the blood and toxic material from the body, Eupolyphoge sinensis promoting blood circulation to remove blood stasis in side
Monarch drug in a prescription；Using radix paeoniae rubra clearing heat and cooling blood, dalbergia wood regulating qi-flowing for relieving pain, leech blood-breaking promoting menstruation as ministerial drug；It is quenched one's thirst with the pueraria lobata deficiency of Yin, corydalis tuber benefit gas stops
Logical, Rhizoma Gastrodiae analgesia qi-restoratives is to make medicine.All medicines share, the effect of playing recuperating qi-blood, vital energy regualting and blood circulation-promoting, clearing and activating the channels and collaterals, activating microcirculation and removing stasis medicinal altogether.
The present invention uses the raw material of different properties, carries out scientific compatibility, and Chinese medicine composition obtained can be effectively improved patient clinical disease
Shape has good curative effect to cardiovascular and cerebrovascular disease, and safety is without side-effects, and does not recur.
2, the preparation method of Chinese medicine composition of the present invention is easy to operate, is suitble to industrialization production.
Specific embodiment
Present invention will be further explained by specific examples below, it should be understood, however, that, these embodiments are only
It is used, is but should not be understood as present invention is limited in any form for specifically describing in more detail.
This part carries out general description to the material and test method that arrive used in present invention test.Although being
It realizes many materials used in the object of the invention and operating method is it is known in the art that still the present invention still uses up herein
It may detailed description.It will be apparent to those skilled in the art that within a context, if not specified, material therefor of the present invention and behaviour
It is well known in the art as method.
Embodiment 1
The present embodiment it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
Weigh rhizome of chuanxiong 25g, Radix Salviae Miltiorrhizae 26g, west safflower 10g, pueraria lobata 18g, radix paeoniae rubra 30g, dalbergia wood 21g, leech 12g, Eupolyphoge sinensis 5g,
Corydalis tuber 12g, Rhizoma Gastrodiae 8g, being ground into partial size after mixing is 100 mesh powders up to the Chinese medicine composition.
Embodiment 2
The present embodiment it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
Weigh rhizome of chuanxiong 44g, Radix Salviae Miltiorrhizae 35g, west safflower 14g, pueraria lobata 15g, radix paeoniae rubra 25g, dalbergia wood 29g, leech 5g, Eupolyphoge sinensis 10g,
Corydalis tuber 5g, Rhizoma Gastrodiae 10g, being ground into partial size after mixing is 90 mesh powders up to the Chinese medicine composition.
Embodiment 3
The present embodiment it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
Weigh rhizome of chuanxiong 35g, Radix Salviae Miltiorrhizae 30g, west safflower 18g, pueraria lobata 18g, radix paeoniae rubra 20g, dalbergia wood 20g, leech 10g, Eupolyphoge sinensis
10g, corydalis tuber 10g, Rhizoma Gastrodiae 8g, being ground into partial size after mixing is 120 mesh powders up to the Chinese medicine composition.
Embodiment 4
The present embodiment it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
1) rhizome of chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, west safflower 25g, pueraria lobata 10g, radix paeoniae rubra 18g, dalbergia wood 25g, leech 8g, Eupolyphoge sinensis are weighed
15g, corydalis tuber 8g, Rhizoma Gastrodiae 5g, are ground into coarse powder after mixing；
2) water of 10 times of raw material gross weight amounts is added in above-mentioned coarse powder, decocts 2h, it is total that raw material is added in filtration in filter residue
The water of 6 times of weight amounts, decocts 1h, filtration, and decocting liquid merging twice staticly settles 20 hours, takes supernatant, be concentrated under reduced pressure into 60 DEG C
When relative density be 1.25 lotion to get the Chinese medicine composition.
Embodiment 5
The present embodiment it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
1) rhizome of chuanxiong 35g, Radix Salviae Miltiorrhizae 30g, west safflower 18g, pueraria lobata 18g, radix paeoniae rubra 20g, dalbergia wood 20g, leech 10g, Eupolyphoge sinensis are weighed
10g, corydalis tuber 10g, Rhizoma Gastrodiae 8g, are ground into coarse powder after mixing；
2) water of 14 times of raw material gross weight amounts is added in above-mentioned coarse powder, decocts 1.5h, raw material is added in filtration in filter residue
The water of 8 times of total weight amounts, decocts 0.5h, filtration, and decocting liquid merging twice staticly settles 12 hours, takes supernatant, be concentrated under reduced pressure into
The lotion that relative density is 1.2 at 60 DEG C is to get the Chinese medicine composition.
Embodiment 6
The present embodiment it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
1) rhizome of chuanxiong 32g, Radix Salviae Miltiorrhizae 50g, west safflower 20g, pueraria lobata 24g, radix paeoniae rubra 15g, dalbergia wood 15g, leech 15g, Eupolyphoge sinensis are weighed
10g, corydalis tuber 10g, Rhizoma Gastrodiae 18g, are ground into coarse powder after mixing；
2) water of 12 times of raw material gross weight amounts is added in above-mentioned coarse powder, decocts 1h, it is total that raw material is added in filtration in filter residue
The water of 6 times of weight amounts, decocts 1h, filtration, and decocting liquid merging twice staticly settles 24 hours, takes supernatant, be concentrated under reduced pressure into 60 DEG C
When relative density be 1.15 lotion to get the Chinese medicine composition.
Embodiment 7
Any obtained powder of Example 1-3, directly pours into capsule, that is, capsule is made.
Embodiment 8
Tablet is made in any obtained powder of Example 1-3, tabletting.
Embodiment 9
Any obtained powder of Example 1-3, granulation, that is, be made granule.
Embodiment 10
Any obtained powder of Example 1-3 is added honey, adds water pill, dry, that is, pill is made.
Embodiment 11
Suitable dextrin is added in any obtained lotion of Example 4-6, directly pours into capsule, that is, capsule is made.
Embodiment 12
Suitable dextrin is added in any obtained lotion of Example 4-6, tablet is made in tabletting.
Embodiment 13
Suitable dextrin is added in any obtained lotion of Example 4-6, granule is made in granulation.
Embodiment 14
Suitable dextrin is added in any obtained lotion of Example 4-6, and honey is added, adds water pill, dry, that is, makes
At pill.
Embodiment 15
Suitable aqueous sucrose solution is added in any obtained lotion of Example 4-6, that is, decoction is made.
Comparative example 1
This comparative example it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
Weigh rhizome of chuanxiong 15g, Radix Salviae Miltiorrhizae 26g, west safflower 10g, pueraria lobata 18g, radix paeoniae rubra 40g, dalbergia wood 21g, leech 12g, Eupolyphoge sinensis 5g,
Corydalis tuber 12g, Rhizoma Gastrodiae 8g, being ground into partial size after mixing is 100 mesh powders up to the Chinese medicine composition.
Comparative example 2
This comparative example it is a kind of for treating the preparation method of the Chinese medicine composition of cardiovascular and cerebrovascular disease:
Weigh rhizome of chuanxiong 25g, Radix Angelicae Sinensis 26g, turmeric 10g, pueraria lobata 18g, radix paeoniae rubra 30g, dalbergia wood 21g, leech 12g, Eupolyphoge sinensis 5g, member
Hu 12g, Rhizoma Gastrodiae 8g, being ground into partial size after mixing is 100 mesh powders up to the Chinese medicine composition.
Pharmacological toxicity test
1 drug accumulation toxicity test
Method: healthy mature male SD rat 30 of weight 220-250g are selected (to be mentioned by Guangdong Province's Experimental Animal Center
For), it is randomly divided into and tests 2 groups and control group, every group 10.Preposition animal is tested in indoor adaptation environment 3 days, room temperature 18-25
DEG C, relative humidity 45-65%.
The SD rat of test 1-2 group distinguishes the daily stomach-filling embodiment of the present invention 2 and the Chinese medicine composition of embodiment 5 is primary,
Before stomach-filling, above-mentioned Chinese medicine composition is mixed well using 40-50 DEG C of water.Beginning given low is 0.1g/kgbw, later by regular
Ascending-dose method is stepped up the dosage of daily stomach-filling, makes up to 2g/kgbw, and continuous 30 days.The SD rat of control group is every
Its distilled water stomach-filling, continuous 30 days.It weighs within every 5 days primary, no an example animal subject is dead, and has no that overt toxicity reacts,
The main organs histological examination such as the heart, liver, lung, kidney, adrenal gland has no obvious lesion.
2 acute toxicity tests
Method: healthy mature male SD rat 15 of weight 220-250g are selected (to be mentioned by Guangdong Province's Experimental Animal Center
For).Preposition animal is tested in indoor adaptation environment 3 days, 18-25 DEG C of room temperature, relative humidity 45-65%.With adult clinical daily
500 times of amount give the Chinese medicine composition (before stomach-filling, being mixed well with 40-50 DEG C of water) of the intragastric administration on mice embodiment of the present invention 1 once, i.e.,
Observation reaction of animals situation, poisoning symptom and death condition are carved, is observed continuously 7.As a result: all animals are strong to deposit, activity freely,
Ingest drinking-water, hair, excreta is no abnormal, has no toxic reaction.
Toxicity test shows that the Chinese medicine composition safety of the embodiment of the present invention is good, and toxicity is extremely low.Pharmacological testing.
Clinical test
1 general information
Patient 135 in August, 2017 with cardiovascular and cerebrovascular disease of in August, 2012 are chosen as study subject, male 82
Example, female 53, the age 45-70 year old, be averaged (55 ± 8.65) year.Wherein hypertension 62, coronary heart disease 45, heart failure 28, disease
For journey in 1-15, average course of disease is (5 ± 4.27) year.This research of two groups of equal informed consents of patient, using random, balanced original
Then, 135 clinical cases are randomly divided into experiment 1-2 group and control 1-3 group.Every group of patient is in gender, age, the course of disease and the state of an illness
Aspect compares, and difference is not statistically significant (P > 0.05), is comparable.
2 methods
Test 1,2 group of patient respectively take orally embodiment 2,4 made from Chinese medicine composition, each 3-5g, twice daily, 15 days
It is as a treatment course.
Chinese medicine composition made from 1,2 group of patient's difference oral contrast example 1,2 of control, each 3-5g, twice daily, 15 days
It is as a treatment course.
It compares 3 groups of patients and receives western medicine routine treatment, daily oral felodipine 5-10ml, one time a day, treated for one within 15 days
Journey.
3 efficacy determinations
Effective: patient's clinical symptoms disappear or mostly disappear after treating, coherence check restore normal level；
Effective: patient's clinical symptoms after treating significantly are improved, and coherence check returns to normal level；
Invalid: the not up to above standard is considered as in vain.
4 results
SPSS20.0 statistics software is used to carry out statistical analysis to data after compiling all data, wherein counting
Carry out χ2(%) is examined, and metering carries out t detection (x ± s) and examines, and P < 0.05 prompts difference to have statistical significance.
By treatment in 1 month, the clinical efficacy comparing result of experimental group and control group was shown in Table 1.
Table 1
| Group | Number of cases | It is effective | Effectively | In vain | Efficient (%) |
| Implement 1 group | 28 | 15 | 9 | 4 | 85.7 |
| Test 2 groups | 30 | 19 | 8 | 3 | 90 |
| Compare 1 group | 25 | 6 | 8 | 11 | 56 |
| Compare 2 groups | 22 | 5 | 8 | 9 | 59.1 |
| Compare 3 groups | 30 | 11 | 10 | 9 | 70 |
Clinical effectiveness shows: experiment 1-2 group treatment effective 34, effective 17, invalid 7, effective percentage is at least 85%,
Effective 22 of 1-3 group treatment is compareed, effective 26, invalid 29, effective percentage is no more than 70%, experimental group patient's treated effect
It is significantly higher than control group, difference has statistical significance (P < 0.05).Illustrate that Chinese medicine composition disclosed by the embodiments of the present invention can
Patients with Cardiovascular/Cerebrovascular Diseases clinical symptoms are effectively relieved, patient clinical treated effect is improved, is worth clinical expansion.
Typical case:
1, Ma, male 51 years old, suffer from hypertension 8 years, throughout the year giddy dizziness, and indistinctly, body is tired out of strength, lassitude for headache,
Few gas uncomfortable in chest, blood pressure 160/100mmHg once took captopril depressor, more felt dizzy uncomfortable, took orally the embodiment of the present invention 2
Chinese medicine composition obtained, about 5g even served 1 month 2 times a day every time, and the symptoms such as dizziness disappear, and blood pressure is normal, follow-up half a year
It does not recur.
2, flood certain, female, 58 years old, bored pain after half a year os presternum was in duration, radiates with back part, be diagnosed as myocardial infarction.
Chinese medicine composition made from the present embodiment 4 is taken, every time about 5g, 2 times a day, taken 1 week, pectoralgia is substantially reduced, continues to take 1
A month, symptom completely eliminated, and did not occurred any discomfort when patient takes, and follow-up half a year does not recur.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (8)
1. a kind of for treating the Chinese medicine composition of cardiovascular and cerebrovascular disease, which is characterized in that the Chinese medicine composition is by following heavy
The raw material of amount number is made: 20-45 parts of rhizome of chuanxiong, 25-50 parts of Radix Salviae Miltiorrhizae, 10-25 parts of west safflower, 10-25 parts of pueraria lobata, radix paeoniae rubra 15-30
Part, 15-30 parts of dalbergia wood, 5-15 parts of leech, 5-15 parts of Eupolyphoge sinensis, 5-15 parts of corydalis tuber, 5-20 parts of Rhizoma Gastrodiae.
2. according to claim 1 for treating the Chinese medicine composition of cardiovascular and cerebrovascular disease, which is characterized in that the Chinese medicine
Composition is prepared from the following raw materials in parts by weight: 25-40 parts of rhizome of chuanxiong, 25-35 parts of Radix Salviae Miltiorrhizae, 10-20 parts of west safflower, pueraria lobata 15-
25 parts, 18-25 parts of radix paeoniae rubra, 15-25 parts of dalbergia wood, 8-15 parts of leech, 5-12 parts of Eupolyphoge sinensis, 5-15 parts of corydalis tuber, 5-10 parts of Rhizoma Gastrodiae.
3. according to claim 1 for treating the Chinese medicine composition of cardiovascular and cerebrovascular disease, which is characterized in that the Chinese medicine
Composition is prepared from the following raw materials in parts by weight: 35 parts of rhizome of chuanxiong, 30 parts of Radix Salviae Miltiorrhizae, 18 parts of west safflower, 18 parts of pueraria lobata, radix paeoniae rubra 20
Part, 20 parts of dalbergia wood, 10 parts of leech, 10 parts of Eupolyphoge sinensis, 10 parts of corydalis tuber, 8 parts of Rhizoma Gastrodiae.
4. according to claim 1 to 3 for treating the Chinese medicine composition of cardiovascular and cerebrovascular disease, which is characterized in that institute
Chinese medicine composition is stated using the water extract of raw material or raw material as active constituent, in addition pharmaceutically acceptable carrier or diluent system
At preparation.
5. according to claim 4 for treating the Chinese medicine composition of cardiovascular and cerebrovascular disease, which is characterized in that the preparation
For any one of capsule, tablet, granule, pill, paste, decoction.
6. a kind of preparation method of any Chinese medicine composition for treating cardiovascular and cerebrovascular disease of claim 1-3,
It is characterized in that, the method are as follows:
Each raw material for weighing corresponding parts by weight, being ground into partial size after mixing is 80-120 mesh powder.
7. a kind of preparation method of any Chinese medicine composition for treating cardiovascular and cerebrovascular disease of claim 1-3,
It is characterized in that, the described method comprises the following steps:
1) each raw material for weighing corresponding parts by weight, is ground into coarse powder after mixing；
2) 10-15 times of the raw material gross weight water measured is added in above-mentioned coarse powder, decocts 1-2h, raw material is added in filtration in filter residue
6-8 times of the total weight water measured decocts 0.5-1h, filtration, and decocting liquid merging twice staticly settles 12-24 hours, takes supernatant, depressurizes
Relative density is the lotion of 1.1-1.3 when being concentrated into 60 DEG C.
8. any Chinese medicine composition of claim 1-3 is preparing answering in the drug for treating cardiovascular and cerebrovascular disease
With.
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