CN110898169A - Medicine composition for preventing and treating dual-purpose cerebrovascular disease and preparation method thereof - Google Patents
Medicine composition for preventing and treating dual-purpose cerebrovascular disease and preparation method thereof Download PDFInfo
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- CN110898169A CN110898169A CN201911224181.5A CN201911224181A CN110898169A CN 110898169 A CN110898169 A CN 110898169A CN 201911224181 A CN201911224181 A CN 201911224181A CN 110898169 A CN110898169 A CN 110898169A
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- preventing
- treating
- leech
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- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 title claims abstract description 13
- 229940079593 drug Drugs 0.000 title abstract description 6
- 239000000203 mixture Substances 0.000 title abstract description 4
- 238000002360 preparation method Methods 0.000 title description 6
- 241000545744 Hirudinea Species 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims abstract description 5
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 5
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 5
- 241001643642 Viticis Species 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims abstract description 5
- 241000305491 Gastrodia elata Species 0.000 claims abstract description 4
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 4
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 4
- 241000244365 Ligusticum sinense Species 0.000 claims abstract description 3
- 244000299790 Rheum rhabarbarum Species 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 238000010298 pulverizing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 5
- 230000009977 dual effect Effects 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract description 2
- 230000002776 aggregation Effects 0.000 abstract description 2
- 238000004220 aggregation Methods 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 210000000936 intestine Anatomy 0.000 abstract description 2
- 210000003734 kidney Anatomy 0.000 abstract description 2
- 210000004185 liver Anatomy 0.000 abstract description 2
- 230000007721 medicinal effect Effects 0.000 abstract description 2
- 230000000069 prophylactic effect Effects 0.000 abstract description 2
- 210000002784 stomach Anatomy 0.000 abstract description 2
- 230000009885 systemic effect Effects 0.000 abstract description 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 2
- 229940116269 uric acid Drugs 0.000 abstract description 2
- 241001468651 Freshwater leech Species 0.000 description 3
- 241000219061 Rheum Species 0.000 description 3
- 241000112528 Ligusticum striatum Species 0.000 description 2
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 206010008087 cerebral arteritis Diseases 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 201000002676 cerebral atherosclerosis Diseases 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 201000005851 intracranial arteriosclerosis Diseases 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of medicines, in particular to a medicine composition for preventing and treating dual-purpose cerebrovascular diseases, which comprises the following raw materials: 30-45g of salvia miltiorrhiza bunge 30-45g of wild pueraria lobata, 24-32g of ligusticum chuanxiong hort, 15-18g of fructus viticis, 24-32g of gastrodia elata, 12-16g of wine-processed rhubarb and 4-6g of fresh leech. The invention has the beneficial effects that: the combination of seven Chinese medicinal materials achieves the dual purposes of preventing and treating cerebrovascular diseases, namely has dual effects of preventing and treating; has therapeutic and prophylactic effects on atherosclerosis of systemic blood vessels; also has the functions of protecting liver and kidney and adjusting intestines and stomach, and has good effects of reducing fat, reducing viscosity, preventing aggregation and reducing uric acid; in the process of processing the medicine, the temperature of the oven is controlled at 63-90 ℃, and the dried leech does not need to be decocted in water for concentration, so that the processing procedure is simplified, the medicinal substances of the leech are less damaged, and the medicinal effect is better. The efficacy is improved, the use amount is reduced, the side effect is reduced, the medicinal materials are saved, and the cost performance is high.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a medicine composition for preventing and treating dual-purpose cerebrovascular diseases and a preparation method thereof.
Background
Cerebrovascular diseases, broadly referring to various diseases of cerebral vessels, include cerebral atherosclerosis, thrombosis, stenosis, occlusion, cerebral arteritis, cerebral artery injury, etc., and are commonly characterized by causing ischemia or hemorrhagic accident of brain tissue, resulting in disability or death of patients. The incidence rate accounts for 1/4-1/2 of total hospitalization cases of the nervous system. The existing medicines for treating cerebrovascular diseases cannot be used for preventing and treating the cerebrovascular diseases, only can be used for preventing or treating the cerebrovascular diseases, and have single effect. In view of the above, the prescription invented by the high-pass printing innovation, the large-dose treatment and the small-dose prevention, the individual treatment according to factors such as sex, age, height, weight, constitution, reaction after taking the medicine and the like, the effect is more exact and the applicability is stronger.
Disclosure of Invention
The invention aims to overcome the problems in the prior art and provides a pharmaceutical composition for preventing and treating dual-purpose cerebrovascular diseases and a preparation method thereof, which can solve the problems in the prior art at least to a certain extent.
In order to achieve the technical purpose and achieve the technical effect, the invention is realized by the following technical scheme:
a pharmaceutical composition for preventing and treating dual-purpose cerebrovascular disease comprises the following raw materials:
30-45g of salvia miltiorrhiza bunge 30-45g of wild pueraria lobata, 24-32g of ligusticum chuanxiong hort, 15-18g of fructus viticis, 24-32g of gastrodia elata, 12-16g of wine-processed rhubarb and 4-6g of fresh leech.
The preparation process includes at least one step of stoving fresh leech in an oven at 63-90 deg.c, and mixing the dried leech with the concentrated water decoction of other material medicine, crushing and capsulizing.
Preferably, the oven temperature is 65 ℃.
The invention has the beneficial effects that: the combination of seven Chinese medicinal materials achieves the dual purposes of preventing and treating cerebrovascular diseases, namely has dual effects of preventing and treating; has therapeutic and prophylactic effects on atherosclerosis of systemic blood vessels; also has the functions of protecting liver and kidney and adjusting intestines and stomach, and has good effects of reducing fat, reducing viscosity, preventing aggregation and reducing uric acid; in the process of processing the medicine, the temperature of the oven is controlled at 63-90 ℃, and the dried leech does not need to be decocted in water for concentration, so that the processing procedure is simplified, the medicinal substances of the leech are less damaged, and the medicinal effect is better. The efficacy is improved, the use amount is reduced, the side effect is reduced, the medicinal materials are saved, and the cost performance is high.
Detailed Description
In order to make the technical means, the creation features, the achievement purposes and the effects of the invention easy to understand, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A pharmaceutical composition for preventing and treating dual-purpose cerebrovascular disease comprises the following raw materials:
45g of salvia miltiorrhiza bunge, 45g of wild pueraria root, 32g of ligusticum wallichii, 18g of fructus viticis, 32g of rhizoma gastrodiae, 16g of wine rhubarb and 6g of fresh water leech.
Example 2
A pharmaceutical composition for preventing and treating dual-purpose cerebrovascular disease comprises the following raw materials:
30g of salvia miltiorrhiza bunge 30g of wild pueraria lobata, 24g of ligusticum wallichii, 15g of fructus viticis, 24g of gastrodia elata, 12g of wine-processed rhubarb and 4g of fresh water leech.
The preparation method at least comprises a processing link, wherein in the processing link, fresh water leeches are put into an oven to be baked, the temperature of the oven is between 63 ℃ and 90 ℃, the baked leeches are not decocted in water for concentration any more, and the dried leeches are directly mixed with the decocted, concentrated and dried substances of other raw material medicines, crushed and encapsulated.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (3)
1. The pharmaceutical composition for preventing and treating dual-purpose cerebrovascular diseases is characterized by comprising the following raw materials:
30-45g of salvia miltiorrhiza bunge 30-45g of wild pueraria lobata, 24-32g of ligusticum chuanxiong hort, 15-18g of fructus viticis, 24-32g of gastrodia elata, 12-16g of wine-processed rhubarb and 4-6g of fresh leech.
2. A process for preparing the composite medicine to prevent and cure cerebrovascular disease includes such steps as baking fresh leech in oven at 63-90 deg.C, mixing it with the dried leech, pulverizing and loading in capsules.
3. A method of manufacture as claimed in claim 2, wherein the oven temperature is 65 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911224181.5A CN110898169A (en) | 2019-12-04 | 2019-12-04 | Medicine composition for preventing and treating dual-purpose cerebrovascular disease and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911224181.5A CN110898169A (en) | 2019-12-04 | 2019-12-04 | Medicine composition for preventing and treating dual-purpose cerebrovascular disease and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110898169A true CN110898169A (en) | 2020-03-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911224181.5A Pending CN110898169A (en) | 2019-12-04 | 2019-12-04 | Medicine composition for preventing and treating dual-purpose cerebrovascular disease and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110898169A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972285A (en) * | 2010-09-30 | 2011-02-16 | 高传印 | Aperient suppository and preparation method thereof |
| CN105832818A (en) * | 2016-06-08 | 2016-08-10 | 四川泰华堂制药有限公司 | Traditional Chinese medicinal preparation for activating blood to dredge vessels and preparation method of traditional Chinese medicinal preparation |
| CN105833051A (en) * | 2016-04-26 | 2016-08-10 | 湖南中医药大学 | Heart protecting and collateral dredging pharmaceutical composition, preparation containing same and application thereof |
| CN108434422A (en) * | 2018-05-18 | 2018-08-24 | 重庆跃龙生物制药有限公司 | Chinese medicine composition and preparation method thereof for treating cardiovascular and cerebrovascular disease |
| CN109045210A (en) * | 2018-11-06 | 2018-12-21 | 赵献军 | A kind of Chinese medicine composition and preparation method thereof for treating cardiovascular and cerebrovascular disease |
| CN109078125A (en) * | 2018-11-13 | 2018-12-25 | 长沙奥佳信息科技有限公司 | A kind of Chinese medicine for treating angioneurotic headache |
-
2019
- 2019-12-04 CN CN201911224181.5A patent/CN110898169A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972285A (en) * | 2010-09-30 | 2011-02-16 | 高传印 | Aperient suppository and preparation method thereof |
| CN105833051A (en) * | 2016-04-26 | 2016-08-10 | 湖南中医药大学 | Heart protecting and collateral dredging pharmaceutical composition, preparation containing same and application thereof |
| CN105832818A (en) * | 2016-06-08 | 2016-08-10 | 四川泰华堂制药有限公司 | Traditional Chinese medicinal preparation for activating blood to dredge vessels and preparation method of traditional Chinese medicinal preparation |
| CN108434422A (en) * | 2018-05-18 | 2018-08-24 | 重庆跃龙生物制药有限公司 | Chinese medicine composition and preparation method thereof for treating cardiovascular and cerebrovascular disease |
| CN109045210A (en) * | 2018-11-06 | 2018-12-21 | 赵献军 | A kind of Chinese medicine composition and preparation method thereof for treating cardiovascular and cerebrovascular disease |
| CN109078125A (en) * | 2018-11-13 | 2018-12-25 | 长沙奥佳信息科技有限公司 | A kind of Chinese medicine for treating angioneurotic headache |
Non-Patent Citations (1)
| Title |
|---|
| 刘永坤;等: "步长脑心通胶囊治疗短暂性脑缺血发作60例疗效观察", 中国实用医药, vol. 4, no. 12, 28 April 2009 (2009-04-28), pages 178 * |
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