CN108465089A - A kind of Chinese medicine composition and preparation method thereof for treating acute stage wind-cold type peripheral facial paralysis - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating acute stage wind-cold type peripheral facial paralysis Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/538—Schizonepeta
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating acute stage wind-cold type peripheral facial paralysis, including following traditional Chinese medicinal material raw materials：10 20 parts by weight of radix bupleuri, 7 13 parts by weight of radix scutellariae, 15 25 parts by weight of Radix Codonopsis, 7 13 parts by weight of schizonepeta, windproof 7 13 parts by weight, 15 25 parts by weight of raw Radix Astragali, 6 12 parts by weight of Radix Angelicae Sinensis, 12 18 parts by weight of cassia twig, 8 12 parts by weight of Radix Paeoniae Alba, 6 11 parts by weight of pueraria lobata, 8 13 parts by weight of ginger, 8 14 parts by weight of jujube, 48 parts by weight of honey-fried licorice root, 39 parts by weight of ephedra.The present invention treats the Chinese medicine composition of acute stage wind-cold type peripheral facial paralysis, and Chinese medicine composition is simple to manufacture, has no toxic side effect, is quick, is better, is used in peripheral facial paralysis acute stage, can effectively shorten the course of disease, reduces the generation of facial paralysis, significant in efficacy.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine, specially a kind of to treat in acute stage wind-cold type peripheral facial paralysis
Drug composition and preparation method thereof.
Background technology
Western medical treatment peripheral facial paralysis is with the trophic nerves drug such as the hormonal medicaments such as oral prednisone and Mecobalamin at present
Main, the complete recovery rate of such method is about 66%~76%, and average course for the treatment of is 34.4 days.
The method of Chinese traditional treatment peripheral facial paralysis is mainly acupuncture and moxibustion therapy and Chinese medicine treatment at present, and the recovery from illness course for the treatment of of this disease is flat
It is 30~45 days.Document shows, the therapies such as acupuncture, Chinese medicine, physical therapy have certain therapeutic effect, it is efficient up to 90% with
On, but cure rate is different in size, and it is easy that there are sequelae.Wherein simple acupuncture treatment, the cure rate about 50.1% in 4 weeks；Needle
Moxibustion combination Chinese medicine combination therapy can be obviously shortened the recovery from illness course for the treatment of, wherein being Qianzheng San, cure rate with the highest prescription of the frequency
About 70%.
Acute stage oral hormone can eliminate lesion local edema, inflammation quickly, promote neurological functional recovery, but application swashs
During element, for basic disease, more patient is susceptible to complication：1, concurrent infection or infection aggravate；2, sclerotin is loose, very
To caput femoris necrosis；3, alimentary canal stress ulcer hemorrhage；4, the common hormone side effect such as moon shaped face or buffalo hump.
Document shows that it is Qianzheng San to be clinically used for the treatment highest square foundation of peripheral facial paralysis frequency of usage at present, is being led
Just dissipate on the basis of be added promoting blood circulation, dredging collateral drug.Also it is an arguement but in acute stage if appropriate for we are used.Have
Person points out that Qianzheng San ingredient is mainly Drug Prepared from Insects, is suitble to the central facial palsies such as obstruction of collateral caused by windphlegm or phlegm stagnation in collateral, not peripheral
Facial paralysis first choice side.
Invention content
In order to solve the above technical problems, the present invention provides a kind of Chinese traditional medicine composition for treating acute stage wind-cold type peripheral facial paralysis
Object and preparation method thereof, the Chinese medicine composition are simple to manufacture, and toxic side effect is small, curative effect is good, with obvious effects, can effectively shorten disease
Journey can be used in acute facial paralysis, significant in efficacy.
It is an object of the present invention to provide a kind of Chinese medicine composition for treating acute stage wind-cold type peripheral facial paralysis,
It includes following traditional Chinese medicinal material raw materials：Radix bupleuri 10-20 parts by weight, radix scutellariae 7-13 parts by weight, Radix Codonopsis 15-25 parts by weight, schizonepeta 7-13
Parts by weight, windproof 7-13 parts by weight, raw Radix Astragali 15-25 parts by weight, Radix Angelicae Sinensis 6-12 parts by weight, cassia twig 12-18 parts by weight, Radix Paeoniae Alba 8-
12 parts by weight, pueraria lobata 6-11 parts by weight, ginger 8-13 parts by weight, jujube 8-14 parts by weight, honey-fried licorice root 4-8 parts by weight, ephedra
3-9 parts by weight.
Further, the traditional Chinese medicinal material raw materials of the Chinese medicine composition include：15 parts by weight of radix bupleuri, 10 parts by weight of radix scutellariae,
20 parts by weight of Radix Codonopsis, 10 parts by weight of schizonepeta, windproof 10 parts by weight, 20 parts by weight of raw Radix Astragali, 10 parts by weight of Radix Angelicae Sinensis, 15 weight of cassia twig
Part, 10 parts by weight of Radix Paeoniae Alba, 10 parts by weight of pueraria lobata, 10 parts by weight of ginger, 10 parts by weight of jujube, 6 parts by weight of honey-fried licorice root, ephedra 6
Parts by weight.
Hereinafter, slightly illustrating to the property etc. of the above-mentioned raw materials of the present invention：
Radix bupleuri：Acrid flavour, hardship, cold nature.Enter liver, gallbladder channel.In inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, preventing malaria of bringing down a fever；
Radix scutellariae：Bitter, it is cold in nature.Enter lung, intestine and small intestine, gallbladder channel.Clearing heat, purging intense-heat, eliminating dampness, decompression, tocolysis；
Radix Codonopsis：It is sweet in flavor, it is mild-natured.Enter spleen, lung channel.Tonifying middle-Jiao and Qi, nourishes blood and promotes the production of body fluid；
Schizonepeta：Acrid flavour, it is warm-natured.Enter lung, Liver Channel.Dispersing wind, relieving exterior syndrome, the malicious promoting eruption of a surname, dissipate stasis of blood hemostasis；
It is windproof：Acrid flavour, sweet, tepor.Enter bladder, liver, the spleen channel.Dispersing wind, relieving exterior syndrome, expel endogenous wind to relieve convulsion, expelling wind and relieving convulsion；
Ephedra：Acrid flavour, slight bitter, it is warm-natured.Enter lung, bladder warp.Inducing sweat and dispelling exogenous evils are freeinged lung and relieving asthma, profit water detumescence；
Raw Radix Astragali：Sweet in flavor, tepor.Enter spleen, lung channel.Tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis to remove edema.
Radix Angelicae Sinensis：Taste sweet, acrid, warm.Enter liver, the heart, the spleen channel.Tonifying blood and regulating menstruation, relaxes bowel at promoting blood circulation and stopping pain.
Cassia twig：Acrid, sweet, warm.Enter the heart, liver, spleen, lung, kidney, bladder warp.Sweating expelling pathogenic factors from muscles and skin, antalgic, activating YANG and prormoting functioning of QI put down punching
It drops inverse；
Radix Paeoniae Alba：Bitter, acid, is slightly cold.Enter liver, the spleen channel.It enriches blood and holds back the moon, soft liver analgesic, yin-nourishing soothing the liver；
Pueraria lobata：It is sweet, pungent, it is cool.Enter stomach, the spleen channel.Expelling pathogenic factors from muscles and skin is brought down a fever, and promoting eruption promotes the production of body fluid to quench thirst, Shengyang Zhixie；
Ginger：It is pungent, tepor.Enter lung, spleen, stomach.Expelling cold and relieving exterior syndrome, warm stomach preventing or arresting vomiting, removing toxic substances；
The present invention monarch drug in a prescription be：Radix bupleuri, cassia twig；
The present invention ministerial drug be：Schizonepeta, windproof, pueraria lobata, raw Radix Astragali, Radix Angelicae Sinensis；
The present invention adjutant be：Radix scutellariae, Radix Codonopsis, Radix Paeoniae Alba, ephedra；
The present invention the medicine that makes be：Ginger, jujube, honey-fried licorice root.
Wind-cold type facial paralysis is the different TCM syndrome types of peripheral facial paralysis, accounts for about 85%, main inducing is that (windowing is slept for chill invasion
Feel, air-conditioning blow-through face, drench with rain and catch a cold).Through speech：" people in chill enters space between skin and muscles not in Ying Wei ".Wind wound is defended, wound of trembling with fear battalion.
Chill sheet from phase factor, must wind first open Xuan Fu, space between skin and muscles, it is so cold that enter channels and collaterals.Wind being YANG-pathogen, easily wound is in upper.The main disease of face paralysis
Shape be distortion of commissure, eyes closed are unfavorable, alarm nose dysfunction, ear after muscle, the muscles along the regular meridians dysfunction such as pain.Mouth, eye are to hide
Total key of mansion vital essence, comes round with the gas in the world, the table for not being, and in not being, is in the entering of table, inner goes out at table, belongs to
In semi-exterior-interior.Mouthful, eye can open that energy is entire, it is opening as it can be seen that entire loses, exactly for pivot as.Shaoyang resembling a pivot, place is semi-exterior-interior,
The gas of the burnt parade of department three.
The evolution of the facial paralysis interpretation of the cause, onset and process of an illness can be summarized as：The sun seeks Wei Bugu, and battalion defends the entire mistake department of opening of sweat pores, and outer card is not understood, then
Chill enters the few sun of napex from pivot, few sun by heresy, then cause main muscle, muscles along the regular meridians dysfunction；Few sun eliminating evil not to the utmost, then turns to belong to
Sun is bright, eventually leads to different degrees of facial paralysis.
The cause of disease of wind-cold type peripheral facial paralysis is chill, sick position in few sun.When acute stage, disease and evil just enters, and sick position table is shallow, more
Delay in Ying Wei.Chill is invaded, and when solution does not solve, only Guizhi decoction is available, total side that Guizhi decoction is typhoid fever, apoplexy, miscellaneous diseases solution are outer；
Mainly in eye, cheek, bicker etc., positive position, shaoyang resembling a pivot, Shaoyang pivot want agent first choice Xiao Chaihu Tang, two sides less for face paralysis position
It is harmonious, organizes as bupleuri and Ramuli Cinnamomi Decoction.
Bupleuri and Ramuli Cinnamomi Decoction comes from Eastern Han Dynasty's last years of a dynasty or reign Zhang Zhongjing《Treatise on Febrile and Miscellaneous Disease》, the party is fifty-fifty by Guizhi decoction and Xiao Chaihu Tang
Amount is harmonious, this side is the side that hinge solution is outer, dredging collateral opens knot, and all sun are few positive, and the Zhi Luozhe that lesion is related to passages through which vital energy circulates all may be used
With it.The main Wen Yang of Guizhi decoction, expelling pathogenic factors from muscles and skin, Xiao Chaihu Tang homophony gas and space between skin and muscles.Yang-energy person, smart then repose, soft then nourishing the muscle and tendon.Treat wind
When cold type peripheral facial paralysis, this Chinese traditional medicine composition is cut out in bupleuri and Ramuli Cinnamomi Decoction on the basis ofization, and addition ephedra, windproof is intended to schizonepeta
Open Xuan Fu (fine hair hole), fur of dispelling, space between skin and muscles cold-evil；Radix Astragali, Radix Angelicae Sinensis, pueraria lobata is added and is intended to warming YANG and invigorating QI, promoting blood circulation and removing obstruction in channels, enhancing
Qi and blood nourishing effect.Entire Chinese traditional medicine composition is intended to the cause of disease for this disease, sick position, distinguishes through medication, rapidly promotes facial nerve function
Restore.
In the present invention, the dosage form of the Chinese medicine composition is the dosage form of this field routine, preferably particle, oral solution
Or spray.
When the Chinese medicine composition is spray：
It preferably further include the auxiliary material of this field spray routine in the Chinese medicine composition.The auxiliary material is preferable
It is one or more in penetration enhancer, wetting agent and preservative.
Preferably, the penetration enhancer is dimethyl sulfoxide (DMSO).The additive amount of the penetration enhancer is this field
Conventional additive amount, preferably 2%-5%.
Preferably, the wetting agent is glycerine.The additive amount of the wetting agent is this field routine additive amount, preferably
It is 2%-5%.
Preferably, the preservative is sorbic acid.The additive amount of the preservative is this field routine additive amount, compared with
Good is 0.05%-0.3%.The percentage is the percentage for accounting for traditional Chinese medicinal material raw materials weight.
When the Chinese medicine composition is oral solution：
It preferably further include the auxiliary material of this field oral solution routine in the Chinese medicine composition.The auxiliary material is preferable
For simple syrup.The additive amount of the simple syrup is this field routine additive amount, and preferably 20% hereinafter, the percentage is
Account for the percentage of the weight of traditional Chinese medicinal material raw materials.
When the Chinese medicine composition is granule：
It preferably further include the auxiliary material of this field granule routine in the Chinese medicine composition.The auxiliary material is preferable
For sucrose.The additive amount of the sucrose is preferably 20% hereinafter, the percentage is the weight percent for accounting for traditional Chinese medicinal material raw materials
Than.
Another purpose according to the present invention, provides the preparation method of above-mentioned Chinese medicine composition, and step includes：It will be described
Traditional Chinese medicinal material raw materials uniformly mix, conventionally prepare, you can.
When the Chinese medicine composition is spray：
The preparation method of the spray is the preparation method of the spray of this field routine, preferably, the system
Preparation Method is：Traditional Chinese medicinal material raw materials are uniformly mixed, are filtered after decoction, concentration filtrate obtains medicinal extract, is diluted with water, you can.
The dosage for the water being added when the described decoction is the dosage of this field routine, and preferably every gram of traditional Chinese medicinal material raw materials add
Enter the water of 5mL-10mL, the water of 6.45mL is added in more preferably every gram of traditional Chinese medicinal material raw materials.
The number filtered after the decoction is preferably 1 time or more, more preferably 3 times.It is filtered after the decoction
Number be more than 1 time when, merging filtrate.
When in Chinese medicine composition further including the auxiliary material of this field spray routine, by the medicinal extract and the auxiliary material
It is uniformly mixed, adds water dilution, you can.
It is filling in spray bottle preferably, after the dilution, sterilizing.The concentration of traditional Chinese medicinal material raw materials is preferable after dilution
For 5 parts by weight/mL-15 parts by weight/mL, more preferably 6.25m parts by weight/mL, the quality of a concentration of traditional Chinese medicinal material raw materials with
The volume ratio of water.The specification of the spray can be 20mL/ bottles.
When the Chinese medicine composition is oral solution：
The preparation method of the oral solution is the preparation method of the oral solution of this field routine, preferably, the system
Preparation Method is：Traditional Chinese medicinal material raw materials are added water to cook, are filtered, you can.
The dosage of the water is the dosage of this field routine, and preferably every gram of traditional Chinese medicinal material raw materials are added 5mL-10mL's
Water.
The number added water to cook is preferably 1 time or more, more preferably 2 times.When the number added water to cook is more than 1
When secondary, merge extracting solution.When the number added water to cook is more than 1 time, the water consumption of the 1st decoction is preferably every gram of Chinese medicine
The water of 9mL is added in raw material, and decocting time is preferably 30 minutes, and the water consumption of the 2nd decoction is preferably every gram of Chinese medicine original
The water of 6mL is added in material, and decocting time is preferably 20 minutes.
Preferably, after concentration, packing, sterilizing.
When in Chinese medicine composition further including the auxiliary material of this field oral solution routine, the auxiliary material adds after concentration.
The specification of the oral solution can be 5mL/ bottles.
When the Chinese medicine composition is granule：
The preparation method of the particle is the preparation method of the granule of this field routine, preferably, the preparation
Method is：By traditional Chinese medicinal material raw materials ethanol water seepage pressure effects, filtrate is recycled in filtering, and concentration filtrate obtains medicinal extract, dry, system
Grain, you can.
Preferably, before extraction, the traditional Chinese medicinal material raw materials are rolled into No. 3 coarse powder.
Preferably, the extraction time of the diacolation is -3 hours 2 hours.
Preferably, a concentration of the 50% of the ethanol water, the percentage is the volume basis that ethyl alcohol accounts for solution
Than.
The dosage of the ethanol water is the dosage of this field routine.Preferably, the amount of the ethanol water
It is 5 times of traditional Chinese medicinal material raw materials quality.
The time of the extraction is preferably -3 hours 2 hours.
The method of the concentration is the method for this field routine.Preferably, the concentration is to be concentrated under reduced pressure.
Preferably, the method for the drying is the method for this field routine, preferably dry or low temperature drying.
Preferably, after the drying, sieving.The sieving sieve was preferably 14-16 mesh sieve.
The beneficial effects of the invention are as follows：
The present invention treats the Chinese medicine composition of acute stage wind-cold type peripheral facial paralysis, Chinese medicine composition of the invention manufacture letter
It is single, it has no toxic side effect, is quick, is better, being used in peripheral facial paralysis acute stage, can effectively shorten the course of disease, after reducing facial paralysis
The generation of disease is lost, it is significant in efficacy.
Specific implementation mode
Below in conjunction with the specific embodiment of the invention, technical scheme of the present invention is clearly and completely described, is shown
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1
The preparation of Chinese medicine composition：
Raw material includes：10 parts by weight of radix bupleuri, 7 parts by weight of radix scutellariae, 15 parts by weight of Radix Codonopsis, 7 parts by weight of schizonepeta, windproof 7 weight
Part, 15 parts by weight of raw Radix Astragali, 6 parts by weight of Radix Angelicae Sinensis, 12 parts by weight of cassia twig, 8 parts by weight of Radix Paeoniae Alba, 6 parts by weight of pueraria lobata, 8 weight of ginger
Part, 8 parts by weight of jujube, 4 parts by weight of honey-fried licorice root, 3 parts by weight of ephedra；
Preparation method：Traditional Chinese medicinal material raw materials are put into 2000ml water, are impregnated 30 minutes, it is fried after adding water to be cooked by slow fire
Liquid is removed slag with filtered through gauze, obtains concoction 1800ml, you can.
Embodiment 2
The preparation of Traditional Chinese medicine composition-type spray：
Raw material includes：15 parts by weight of radix bupleuri, 10 parts by weight of radix scutellariae, 20 parts by weight of Radix Codonopsis, 10 parts by weight of schizonepeta, windproof 10 weight
Measure part, 20 parts by weight of raw Radix Astragali, 10 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of cassia twig, 10 parts by weight of Radix Paeoniae Alba, 10 parts by weight of pueraria lobata, ginger
10 parts by weight, 10 parts by weight of jujube, 6 parts by weight of honey-fried licorice root, 6 parts by weight of ephedra；
Preparation method：
1) traditional Chinese medicinal material raw materials are crushed, is decocted 3 times, each decoction is 1000mL with water, filtering, merging filtrate, and decompression is dense
Contracting filtrate obtains medicinal extract；
2) 3% glycerine and the medicinal extract in step 1) are stirred evenly, 3% dimethyl sulfoxide (DMSO) and 0.2% mountain is added
Pears acid, distilled water mixing to 2000mL；The percentage is the weight percent for accounting for traditional Chinese medicinal material raw materials；
3) it is fitted into spray bottle, sterilizes, you can.The specification of spray can be 20mL/ bottles.
Embodiment 3
The preparation of Chinese medicine composition oral solution：
Raw material includes：20 parts by weight of radix bupleuri, 13 parts by weight of radix scutellariae, 25 parts by weight of Radix Codonopsis, 13 parts by weight of schizonepeta, windproof 13 weight
Measure part, 25 parts by weight of raw Radix Astragali, 12 parts by weight of Radix Angelicae Sinensis, 18 parts by weight of cassia twig, 12 parts by weight of Radix Paeoniae Alba, 11 parts by weight of pueraria lobata, ginger
13 parts by weight, 14 parts by weight of jujube, 6 parts by weight of honey-fried licorice root, 9 parts by weight of ephedra；
Preparation method：
1), traditional Chinese medicinal material raw materials are crushed, the water of 1200mL is added to decoct, are boiled 30 minutes, are filtered, then add the decocting of 800mL
It boils 20 minutes, filters, merging filtrate, be concentrated by evaporation to 25mL, 10% simple syrup is added, be uniformly mixed, the percentage is
Account for the weight percent of traditional Chinese medicinal material raw materials.
2) it dispenses, sterilizing, you can；The specification of oral solution is 5mL/ bottles.
Embodiment 4
The preparation of Chinese medicinal composition granules：
Raw material includes：18 parts by weight of radix bupleuri, 12 parts by weight of radix scutellariae, 23 parts by weight of Radix Codonopsis, 12 parts by weight of schizonepeta, windproof 11 weight
Measure part, 21 parts by weight of raw Radix Astragali, 10 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of cassia twig, 10 parts by weight of Radix Paeoniae Alba, 10 parts by weight of pueraria lobata, ginger
11 parts by weight, 12 parts by weight of jujube, 7 parts by weight of honey-fried licorice root, 7 parts by weight of ephedra；
Preparation method：
1) traditional Chinese medicinal material raw materials are rolled into No. 3 coarse powder, with 50% ethanol water diacolation of 5 times of amounts of traditional Chinese medicinal material raw materials quality
Method is extracted 2 hours, filtering, is recycled filtrate and is concentrated thick paste, obtains medicinal extract；The sucrose for adding 10%, stirs evenly, dry；Described hundred
Divide than being the weight percent for accounting for traditional Chinese medicinal material raw materials；
2) it pelletizes：14-16 mesh sieve is crossed, particle is made, dries or low temperature drying；
3) it packs：The specification of packaging can be 50g/ bags.
Embodiment 5
Case
Rely certain, female, 37 years old, first visit on the 28th in 2 months in 2017, patient right side facial paralysis 3 days.It examines and sees：Right side volume line disappears, and lifts eyebrow
Cannot, right eye cannot be firmly closed completely, and see distinguished and admirable tear, alarm without motion on the right side of nose, right side bicker without motion when smile, and the drum cheek is right
Side leakage gas.Patient had tired, history of having a cold before three days, the micro- red tongue of pale tongue is thin white, floating and tense pulse.Head CT shows that brain is without exception.
Diagnosis：Peripheral facial paralysis；It is dialectical to attack network type for chill；
The rules for the treatment of：Harmonizing yingfen and weifen, expelling pathogenic factors from muscles and skin dredging collateral.
Treatment：1. routine needling
2. extract oral：
Radix bupleuri 15g, radix scutellariae 10g, Radix Codonopsis 20g, schizonepeta 10g, windproof 10g, raw Radix Astragali 20g, Radix Angelicae Sinensis 10g, cassia twig 15g, in vain
Chinese herbaceous peony 10g, pueraria lobata 10g, ginger 10g, jujube 10g, honey-fried licorice root 6g, ephedra 6g.
The course for the treatment of：1 time a day, 5 times as a treatment course for acupuncture treatment, every course for the treatment of interval 2 days；Decoction of medicinal ingredients daily one is secondary, divides after decoction
One after each meal twice.Scale assessment is carried out per course for the treatment of foot couple curative effect, fully recovers in advance, stops treating.
As a result：The 5th, the 10th time, the facial functional evaluation of the 15th progress after first visit, treatment, patient, which treats 13 times, to fully recover from an illness
More, it the results are shown in Table 1
The facial functional evaluation of different phase after 1 acupuncture and medication in combination facial paralysis of table
Conclusion
The Chinese medicine composition of the present invention has the function of blood-nourishing, promoting blood circulation, cold extermination, soft muscle, facial vessels can be promoted to expand, blood
Fortune is sufficient, and facial nutrition is improved, and metabolism is further vigorous, is conducive to inflammation, absorption of edema, and it is extensive to accelerate facial nerve function
It is multiple.It is decoction of medicinal ingredients combination acupuncture treatment facioplegia short treating period, better, be better than simple acupuncture treatment, be it is a kind of effectively, safety
Method is worth promoting and applying in clinic.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (9)
1. a kind of Chinese medicine composition for treating acute stage wind-cold type peripheral facial paralysis, it is characterized in that：Including following traditional Chinese medicinal material raw materials：
Radix bupleuri 10-20 parts by weight, radix scutellariae 7-13 parts by weight, Radix Codonopsis 15-25 parts by weight, schizonepeta 7-13 parts by weight, windproof 7-13 parts by weight,
Raw Radix Astragali 15-25 parts by weight, Radix Angelicae Sinensis 6-12 parts by weight, cassia twig 12-18 parts by weight, Radix Paeoniae Alba 8-12 parts by weight, pueraria lobata 6-11 weight
Part, ginger 8-13 parts by weight, jujube 8-14 parts by weight, honey-fried licorice root 4-8 parts by weight, ephedra 3-9 parts by weight.
2. the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 1, which is characterized in that institute
The traditional Chinese medicinal material raw materials for the Chinese medicine composition stated include：15 parts by weight of radix bupleuri, 10 parts by weight of radix scutellariae, 20 parts by weight of Radix Codonopsis, schizonepeta 10
Parts by weight, windproof 10 parts by weight, 20 parts by weight of raw Radix Astragali, 10 parts by weight of Radix Angelicae Sinensis, 15 parts by weight of cassia twig, 10 parts by weight of Radix Paeoniae Alba, Pueraria lobota
10 parts by weight of root, 10 parts by weight of ginger, 10 parts by weight of jujube, 6 parts by weight of honey-fried licorice root, 6 parts by weight of ephedra.
3. the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 1 or 2, feature exist
In the dosage form of the Chinese medicine composition is one kind in particle, oral solution or spray.
4. the preparation method of the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 1 or 2,
It is characterized in that, the Chinese medicine composition is spray, include the following steps：
Traditional Chinese medicinal material raw materials are uniformly mixed, are filtered after decoction, concentration filtrate obtains medicinal extract, is diluted with water, you can；When the described decoction
The dosage of the water of addition is the water that 5mL-10mL is added in every gram of traditional Chinese medicinal material raw materials；The number filtered after the decoction is preferably
1 time or more.
5. the preparation method of the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 1 or 2,
It is characterized in that, the Chinese medicine composition is oral solution, include the following steps：
Traditional Chinese medicinal material raw materials are added water to cook, are filtered；The dosage of the water is the water that 5mL-10mL is added in every gram of traditional Chinese medicinal material raw materials；
The number added water to cook is preferably 1 time or more；After concentration, packing, sterilizing.
6. the preparation method of the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 1 or 2,
It is characterized in that, the Chinese medicine composition is granule, include the following steps：
By traditional Chinese medicinal material raw materials ethanol water seepage pressure effects, filtrate is recycled in filtering, and concentration filtrate obtains medicinal extract, dry, granulation.
7. the preparation method of the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 6,
It is characterized in that, before extraction, the traditional Chinese medicinal material raw materials is rolled into No. 3 coarse powder.
8. the preparation method of the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 6,
It is characterized in that, the extraction time of the diacolation is -3 hours 2 hours.
9. the preparation method of the Chinese medicine composition for the treatment of acute stage wind-cold type peripheral facial paralysis according to claim 6,
It is characterized in that, the time of the extraction is preferably -3 hours 2 hours.
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