CN102688459A - Traditional Chinese medicine composite for curing cervical spondylosis and preparation method thereof - Google Patents
Traditional Chinese medicine composite for curing cervical spondylosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composite for curing the cervical spondylosis and a preparation method of the traditional Chinese medicine composite. The traditional Chinese medicine composite comprises the following components in parts by weight: 6-20 parts of antler, 10-40 parts of astragalus mongholicus, 6-20 parts of eucommia ulmoides, 10-25 parts of white paeony root, 2-10 parts of cinnamon, 6-15 parts of fructus liquidambaris, 5-20 parts of mustard, 6-20 parts of red flower, 6-20 parts of radices sileris and 5-20 parts of turmeric. The preparation method comprises the following steps of: decocting the antler by water, concentrating into condensed paste, distilling the cinnamon, the mustard, the radices sileris and the turmeric by adding water to extract the volatile oil, merging and decocting the astragalus mongholicus, the eucommia ulmoides, the white paeony root, the fructus liquidambaris, the red flower and the volatile oil-extracted dregs of the medicine by water, filtering, merging the filter liquor and the volatile oil-extracted water liquid, concentrating into a water-decocted concentrated solution, carrying out ethanol precipitation and concentrating into the water-decocted ethanol precipitation condensed paste; and merging the condensed paste and adding auxiliary materials to pelletize. The traditional Chinese medicine composite disclosed by the invention has the effects of reinforcing kidney to strengthen yang, tonifying Qi and activating blood, and activating meridians to stop pain, is suitable for'the deficiency of liver and kidney, and the deficiency of qi and blood type' cervical spondylotic radiculopathy, and is prominent in clinical therapeutic effect..
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese medicine of treating cervical spondylosis and preparation method thereof.
Background technology
With the arrival of aged tendency of population, cervical spondylosis has become a kind of commonly encountered diseases with the quickening pace of modern life, and what wherein, that spondylotic radiculopathy belonged to was the most common, hazardness is maximum is a kind of.Cervical spondylotic radiculopathy (Cervical spondylotic radiculopathy; CSR) be meant because the cervical vertebra regression; Factors such as root compression is urgent cause its domination zone cutting pains to occur or cross electricity appearance scurrying fiber crops, and most of patients readme pain has had a strong impact on quality of life unbearably.According to statistics, nearly 60% old people suffered from or was just suffering from this disease.Cervical spondylotic radiculopathy belongs to Chinese medicine " BI-syndrome involved the tendon ", " arthralgia due to stagnation of blood " category; Mainly weak, caused by liver and kidney deficiency by plain body, damage of essence can not moisten the nourishing muscle and tendon bone, causes blockage of main and collateral channels; Due to QI-blood circulation is obstructed, so be " caused by liver and kidney deficiency, qi and blood deficiency " CSR patient mostly clinically.It is low to seek a kind of cost, and the medicine of the treatment CSR that toxic and side effects is little is a problem that presses for solution.Medicine is divided into Western medicine and Chinese medicine.Western medicine does not still have exclusive medicine, adopts medicines such as analgesic, nonsteroidal anti inflammatory medicine, steroidal class antibiotic medicine more.But because side effect is more, gastrointestinal side effect is obvious, has limited the prolonged application of medicine.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine of treating cervical spondylosis and preparation method thereof, this kind Chinese medicine ability reinforcing the kidney and supporting YANG, benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain.Chinese medicine convenient in application of the present invention, drug effect is definite, and therapeutic effect is good.
The technical scheme that the present invention takes is:
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 6-20 part, Radix Astragali 10-40 part, Cortex Eucommiae 6-20 part, Radix Paeoniae Alba 10-25 part, Cortex Cinnamomi 2-10 part, Fructus Liquidambaris 6-15 part, Semen Sinapis 5-20 part, Flos Carthami 6-20 part, windproof 6-20 part, Rhizoma Curcumae Longae 5-20 part.
The Chinese medicine of above-mentioned treatment cervical spondylosis, preferred weight part ratio consists of: Cornu Cervi 8-15 part, Radix Astragali 12-30 part, Cortex Eucommiae 8-15 part, Radix Paeoniae Alba 12-20 part, Cortex Cinnamomi 3-9 part, Fructus Liquidambaris 7-10 part, Semen Sinapis 6-15 part, Flos Carthami 8-15 part, windproof 8-15 part, Rhizoma Curcumae Longae 6-15 part.
The Chinese medicine of above-mentioned treatment cervical spondylosis, further preferred weight part ratio consists of: Cornu Cervi 10-12 part, Radix Astragali 15-25 part, Cortex Eucommiae 9-12 part, Radix Paeoniae Alba 13-18 part, Cortex Cinnamomi 4-6 part, Fructus Liquidambaris 7-9 part, Semen Sinapis 7-10 part, Flos Carthami 9-12 part, windproof 9-12 part, Rhizoma Curcumae Longae 7-12 part.
In the above-mentioned Chinese medicine, the preferred Radix Astragali (processed with Mel) of the Radix Astragali wherein; The Cortex Eucommiae preferred salt Cortex Eucommiae; Semen Sinapis is preferably fried Semen Sinapis.
A kind of preparation method of Chinese medicine of treating cervical spondylosis comprises the steps:
(1) Cornu Cervi decocte with water filters, and is condensed into condensed cream, and is subsequent use;
(2) Cortex Cinnamomi, Semen Sinapis, windproof, Rhizoma Curcumae Longae are added water distillation and extraction volatile oil, volatile oil is encapsulated with for use with beta-schardinger dextrin-, and medicinal residues are deposited in addition, and combining medicine is in decocting liquid;
(4) with the Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water; Filter, filtrating and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and are condensed into water drug-decocting concentrating liquid;
(5) water drug-decocting concentrating liquid is added ethanol and stir, leave standstill, deposition filters, and filtrate recycling ethanol also is condensed into the water decoction-alcohol sedimentation condensed cream, and is subsequent use;
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add adjuvant and stir spray drying;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, tender flavor agent mix homogeneously, dry granulation.
The preparation method of Chinese medicine of above-mentioned treatment cervical spondylosis, preferred following steps:
(1) with Cornu Cervi decocte with water 2-4 time, add medicine material medicine gross mass 6-20 water doubly at every turn, decocted 1-3 hour at every turn, filter, being concentrated into relative density is the condensed cream of 1.05-1.20 (50-80 ℃);
(3) Cortex Cinnamomi, Semen Sinapis, windproof, Rhizoma Curcumae Longae are added its quality 3-6 water doubly, distillating extracting oil, extraction time 4-8 hour, volatile oil was with the beta-schardinger dextrin-inclusion;
(4) Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water 2-3 time adds medicine material medicine gross mass 6-12 water doubly at every turn, decocts 1-2 hour at every turn; Filter; Decocting liquid and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and being concentrated into relative density is the concentrated solution of 1.05-1.15 (50-80 ℃), is water drug-decocting concentrating liquid;
(5) stir adding 95% (V/V) ethanol in the water drug-decocting concentrating liquid, addition be the concentrated solution quality 1.5-2 doubly (m/m) staticly settle and filter, with filtrate recycling ethanol and be concentrated into the condensed cream that relative density is 1.10-1.22 (50-80 a ℃);
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add adjuvant and stir spray drying;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, tender flavor agent mix homogeneously, dry granulation.
The inclusion of the described volatile oil of above-mentioned steps (3) adds suitable quantity of water to grind well or stir for the beta-schardinger dextrin-of volatile oil 5-12 times quality, and the back drips volatile oil, grinds or stirs, and inclusion complex 40-50 ℃ drying grinds, and gets the beta-cyclo dextrin included compound of volatile oil.
The described adjuvant addition of above-mentioned steps (7) for the 0.2-0.8 that mixes the condensed cream solid content doubly, institute adds adjuvant and is the adjuvant of knowledge altogether pharmaceutically, like dextrin etc.
The described tender flavor agent addition of above-mentioned steps (8) is the 0.1-0.4% of spray-dired medicated powder quality, and institute adds the agent of tender flavor and is pharmaceutically conventional tender flavor agent.
The present invention is directed to " deficiency of the liver and kindey, Qi deficiency blood stasis type " cervical spondylotic radiculopathy, have reinforcing the kidney and supporting YANG, benefiting QI for activating blood circulation, the effect of removing obstruction in the collateral to relieve pain.
Cornu Cervi is the angle base that come off spring in next year after ossified angle of animal in deer family Cervus elaphus linnaeus or Cervus nippon Temminck or the saw young pilose antler in the side.Function the kidney warming sun, bone and muscle strengthening, promoting the circulation of blood detumescence.Be used for insufficiency of kidney-YANG, impotence and seminal emission, spinal column cold type of pain, swelling and pain due to blood stasis.Shennong's Herbal: " temperature.Main malignant boil carbuncle, by evil gas, stagnant blood is in the moon." " Mingyi Bielu ": " and salty in the mouth, tepor, nontoxic.Remove few abdomen blood shoot, pain along the spinal column, folding is hindered stagnant blood, QI invigorating." " Japan hanako materia medica ": " treat to suffer from the swollen pyretic toxicity of carbuncle sore etc., vinegar Fu that rubs; Take off smart hematuria, night dream ghost is handed over, and controls it, the water clothes that rub; Children's's congenital deformity of the tongue, thrush is processed and is pressed it." Compendium of Material Medica: " Cornu Cervi is given birth to the promoting the circulation of blood of then dispelling the heat, and detumescence exorcises evil spirits; Ripe usefulness is the kidney tonifying tonify deficiency then, and strong essence is invigorated blood circulation; The refining frost is endured cream, then specially in nourishing." " dredge the Sheng Nong's herbal classic ": " and Cornu Cervi, the male character types in Chinese operas, usu. referring tov the bearded character be salty in the mouth temperature then, only heat radiation, and bad odor is warded off in the promoting the circulation of blood detumescence.Saltyly can go into the blood softening the hard mass, temperature can pass through and be loose evilly, so main malignant boil carbuncle, by evil gas, and stagnant blood is in the moon, few abdomen blood agglomeration pain, folding is hindered card such as stagnant blood also, the liver genus is positive, the YANG invigorating event again can QI invigorating also." Bencao Congxin ": " " curing surplus " said: the red swollen and pain of ecthyma is arranged, with medicine of a cold nature person more for a long time, but when use warm medicine, like Cornu Cervi ash, burnt hair, Olibanum and so on, this negative and positive summer-heat tremble with fear contact reason also.”
The Cortex Eucommiae is the dry bark of the Eucommiaceae plant Cortex Eucommiae.The function invigorating the liver and kidney, bone and muscle strengthening.Be used for deficiency of the liver and kindey, soreness of waist and knee joint, muscles and bones is unable, has a dizzy spell.Shennong's Herbal: " acrid in the mouth, flat.Main pain along the spinal column.Invigorating middle warmer benefit vital essence, hard muscles and bones, strong will, wet except that itching under cloudy, dribbling urination.Clothes are made light of one's life by commiting suicide anti-old for a long time." " Mingyi Bielu ": " and sweet, temperature, nontoxic.Ache in the main foot, do not desire to trample ground." " Japan hanako materia medica ": " control impairment of the kidney caused by overstrain, the spinal column contraction.Be used as medicine and process usefulness." " medicine origin ": " warm in nature, acrid-sweet flavor, abnormal smells from the patient are all thin, and be heavy and fall, and the moon is also.It uses strengthening bone and muscle, and the weak no Lixing of foot." Compendium of Material Medica: " Cortex Eucommiae, ancient prescription are only known nourishing kidney, and only the Wang Haogu speech is a Liver Channel edema caused by disorder of QI medicine, and the profit liver is dry, and tonifying liver is empty, send out the former times people and do not send out also.The benefit liver governing tendons, kidney governing bones, kidney fill that then bone is strong, and the muscle tendon that liver is filled bends and stretches utilization, all belongs to muscle.Cortex Eucommiae color is purple and moisten, the little suffering of sweet in the mouth, and its colour temperature is flat, and Gan Wenneng mends, and little suffering can be moistened, and the kidney invigorating so can go into liver gives making mother in fact also." " book on Chinese herbal medicine converges and says ": " and Fang Shi " directing at " cloud: the void of all parts of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the non-Cortex Eucommiae is not mended, and the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is wet, and the non-Cortex Eucommiae is unfavorable, the acid of sufficient shin, the non-Cortex Eucommiae is not gone, and the waist knee joint is pain, and the non-Cortex Eucommiae is not removed.Right color is purple and dry, and matter is continuous and tough, temperature and mending, and the liver and the kidney tonifying is really for wanting agent." " proper book on Chinese herbal medicine ": " Cortex Eucommiae, bitter in the mouth is hot, people's meridian of Foot-JUE YIN.Cure mainly deficiency of the liver." Cornu Cervi, Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali.Sweet in the mouth, slightly warm in nature.Return spleen, lung meridian.Go into edema caused by disorder of QI.But the merit tonifying Qi and lifting yang, the Tuoli expelling pathogenic factors from the exterior." all families of solar corona book on Chinese herbal medicine " Yan Qike " help gas, strengthening bone and muscle is put on flesh, enrich blood ... metrorrhagia, leukorrhagia "." medicine origin " is carried it: " tonifying the lung gas, real fur, eliminating the pathogens from the lung moderate heat, stringy pulse spontaneous perspiration.Be apt to control weakness of the spleen and stomach, the skin infection blood vessels are not all right, expelling the toxic substance from the body with tonic YIN syndrome skin infection." Shennong's Herbal: " main carbuncle loses skin ulcer for a long time, the evacuation of pus pain relieving; Strong wind leprosy disease, five hemorrhoid scrofula, tonify deficiency, children's's all kinds of diseases and ailments." " Mingyi Bielu ": " control the dirty ailment said due to cold or exposure gas of married woman's, by stagnant blood between the five internal organs, it is deficient to mend the husband, and the five kinds of over strain weakness and emaciation quenches the thirst, stomachache dysentery, QI invigorating, Li Yin gas." " property of medicine opinion ": " and control carbuncle on the back, the main dyspnea due to deficiency of interior benefit, renal failure, deafness is treated cold and heat.”
The Radix Paeoniae Alba is the dry root of ranunculaceae plant Radix Paeoniae.The function nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.Be used for blood deficiency and yellow complexion, limb pain twin, it is dizzy to have a headache." Mingyi Bielu ": " acid, flat, be slightly cold.Slightly poisonous.Clear and coherent blood vessels are in delaying.Dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine.Subduing inflammation, row cold and heat when (controlling), attacked by pestiferous factors stomachache, lumbago." Shennong's Herbal: " and bitter in the mouth, flat.Main pathogen stomachache is removed arthralgia due to stagnation of blood, and is broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." the liver benefiting spleen of enriching blood is Kidney-Yin, and receipts are taken the photograph the at random of temper, and throwing off restraint of irritability is horizontal, and then the Radix Paeoniae Alba is also; Lead the stasis of blood by blood, the removing mass drop-down, then Radix Paeoniae Rubra is also.So tonifying YIN nourishes blood, moisten the liver spleen, all use the Radix Paeoniae Alba; The row of invigorating blood circulation stagnates, and infections poison in Xuanhua is all used Radix Paeoniae Rubra." cloud again: " the bitter and little acid of white person, can benefit lunar spleen is cloudy, and receives the atmosphere of laxing, also tonification liver-yin, and quiet first and second perverse and unreasonable manner.”
Flos Carthami is the dried floral of feverfew Flos Carthami.Have and invigorate blood circulation, the effect of eliminating stasis to stop pain.Be used for traumatic injury, blood stasis is had a pain, and also can be used for the carbuncle skin infection." Kaibao Bencao ": " its Seedling life is smashed to pieces, applies trip and swells." " Amplification on Materia Medica addendum ": " and how to bleed with broken, few with nourishing blood." Compendium of Material Medica: " invigorate blood circulation and moisturize, pain-relieving powder for treating is swollen, stimulates the menstrual flow." Radix Astragali, the Radix Paeoniae Alba, Flos Carthami benefiting QI for activating blood circulation.
Cortex Cinnamomi is the cinnamomic dry bark of canella.It is supporing yang that function is mended fire, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian.Be used for the sexual impotence cold womb, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily upward floating of YANG in deficiency condition, dizzy conjunctival congestion.Shennong's Herbal: " male osmanthus, acrid in the mouth, temperature.Your Majesty's gas cough with dyspnea, the stagnation of QI sore throat is told suction, sharp joint, invigorating the spleen and replenishing QI.Clothes are logical refreshing for a long time, and it is not old to make light of one's life by commiting suicide." " property of medicine opinion ": " bitter in the mouth is hot, and is nontoxic.Cure mainly nine types of precordial pain, kill three worms, main removing blood stasis, the tonneau moon closes, and controls weak foot, and numbness is meciless, and retention of placenta removes cough with dyspnea, and stagnation of QI is gathered around numbness, ends cold air in the abdomen, and is unbearably painful.Main dysentery is controlled nasal polyp." " Japan hanako materia medica ": " and control all pathogenic wind, mend five kinds of strain and seven kinds of impairment, logical nine orifices, sharp joint, benefit is smart, makes eye bright, warm waist knee joint, broken mass beside the umbilicus is chronic, and the congestion that disappears is controlled migratory arthralgia joint contractura, reuniting the fractured tendons and bones, granulation promoting meat." Materia Medica of Decoction: " it is not enough to mend the gate of vitality, boosting source of fire for eliminating abundance of yin." Compendium of Material Medica: " control arthralgia due to cold, wind is dark, and excess of YIN is lost blood, dysentery, infantile convulsion." " book on Chinese herbal medicine is just ": " precisely because sweet in the mouth, so spleen reinforcing soil, all livers are evil to be restrained native and not to have a fiery person for osmanthus, the YIN pathogen of kind suppressing the hyperactive liver wood, and do not know the kind yang-energy that helps liver and gall, with this utmost point second ..." " book on Chinese herbal medicine converge with speech ": " Cortex Cinnamomi, the medicine of controlling chronic diseases is also.It is contrary that the empty deficiency of all units and YANG-depletion are fainted, or trusted subordinate's lumbago and tell to vomit and have loose bowels, or heart kidney prolonged deficiency and syndrome of aversion to cold lasting day and night with cold limbs is timid cold, or renal mass colic of cold type and attacking dash desire dead; Or the cold syndrome of the stomach ascarid goes out and heart diaphragm distension, or QI and blood condensation and passages through which vital energy circulates checks, and false this rich sweet suffering is hot greatly, the thing in following the walking; Strengthen the gate of vitality's sun, plant the gas of heart kidney, a surname leads hundred medicines; Nothing institute avoids out of fear, the long then the moon of sun is disappeared certainly, and preceding all cards is from moving back."" Do not record ":" Lee Hepatopulmonary gas, confidants cold and heat, cold diseases, cholera transferred tendons, headache, back pain, sweating, stop annoying, just spit, cough, nasal Weng, abortion, temperature, strong bones, blood, Li Shu insufficient advocacy hundred drugs." Cortex Cinnamomi strengthens the function that monarch drug helps kidney yang.
Fructus Liquidambaris is the drying and ripening infructescence of Hamamelidaceae plant Chinese sweet gum.The function dispelling, collateral-activating, diuretic stimulates the menstrual flow.Be used for arthralgia, numbness contracture.Supplementary Amplifications of the Compendium of Materia Medica: " ward off but pestilence of miasma, the dehumidifying that makes eye bright, the meridians contracture of relaxing, whole body arthralgia pain, trick and lumbago, its flue gas of smelling that burns is all healed." " the big ability of its property is led to acupoints of twelve meridians, uses it so " the lifesaving sea of bitterness " harnesses the river to expand, and can search by FUSHUI also with it." " south of the Five Ridges gather medicinal herbs record ": " dispelling the wind and dampness pathogens multiple abscess pain and swollen ulcer drug." " Sichuan Chinese medicinal herbal ": " bitter, little puckery, flat.Promoting the circulation of QI to alleviate the stagnation in middle-JIAO, promoting blood circulation to remove obstruction in the collateral, diuretic.Be used to the abdominal distention of having a stomachache, menoxenia, whole body rheumatic arthralgia, edema, dysuria.”
Semen Sinapis is the dry mature seed of crucifer Caulis et Folium Sinapis albee or mustard.Hot, warm, return lung meridian.Tool resolving mass and removing the obstruction of the collateral analgesic effect is used for the stagnant meridians of expectorant, joint numbness, pain, carbuncle of yin nature toxic swelling." Mingyi Bielu ": " master penetrates worker and chronic infectious disease gas, goes up gas, diaphoresis, cold, the yellowish complexion of chest and diaphragm expectorant." Compendium of Material Medica: " and the promoting the circulation of QI eliminating phlegm, remove cold warm in, the swollen pain relieving of loosing, control breathe heavily cough, regurgitation, numbness wood beriberi, all pains of muscles and bones waist joint.”
Windproof is the dry root of umbelliferae Saposhnikovia divaricata.The function expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Be used for rheumatic arthralgia, the rubella pruritus.Shennong's Herbal: " sweet in the mouth, temperature.Main big dizziness due to wind pain, aversion to wind, ailment said due to cold or exposure, blindness does not have finding, is in fashion the whole body, arthralgia, stuffy sensation with restlessness." " Mingyi Bielu ": " and suffering, nontoxic.Cure mainly hypochondriac pain, side of body wind, women's head-ornaments go, and the extremity contraction is anxious, convulsion in the word milk gold skin ulcer." " Japan hanako materia medica ": " and wind as controlling 36, all labor of man are bad, and the invigorating middle warmer benefit is refreshing, blepharitis marginalis, arresting lacrimation, and paralysis is slow, and tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight can be calmed the nerves and decided think of, even gaseous pulse." " book on Chinese herbal medicine justice ": " and (" not record ") interior convulsion two words, directly word milk gold skin ulcer is made sentences and phrases, and wind and tetanus two are demonstrate,proved among the promptly new product; All having and send out convulsion one time, is blood deficiency and endogenous wind is instigated, non-external ailment said due to cold or exposure; So say interior convulsion, and windproof also can extensively treating, quite seemingly close the exogenous wind endogenous wind and carry out persistently.Right ancients from external ailment said due to cold or exposure treatment, are with attack of convulsion after delivery with apoplexy one card invariably, and opisthotonus, " a thousand pieces of gold ", " outer platform " all drench sides such as wine with bean, and pure to dispel the wind be main to deliver.Postpartum convulsion is fainted actually, gold wound is broken hinders the two, is suddenly taken advantage of by cold wind though have, and being suitable for one of induces sweat demonstrate,proves, and know that the two is all after blood prostration; The moon is not contained sun, incites in the liver-wind, thinks the convulsion clonic convulsion, and is especially most; This then is suitable for the YANG hyperactivity suppressing endogenous wind stopping, and is calm for urgently, and ten thousand can not reuse wind medicine, prevents that it is ruthless and tyrannical." not Lu " interior convulsion two words must the non-windproof hot temperature person of dispersing can absurdly try.”
Rhizoma Curcumae Longae is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae.The circulation of qi promoting of function removing blood stasis, inducing menstruation to relieve menalgia.Be used for the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, rheumatism shoulder arm pain." Newly Revised Canon of Materia Medica ": " acrid in the mouth, hardship, Great Cold, nontoxic.Main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, and removing blood stasis removes wind heat, subduing inflammation, power is strong in Radix Curcumae." " Japan hanako materia medica ": “ Zhi mass in the abdomen clot, carbuncle, logical menstruation is controlled to fall and is pounced on blood stasis, and the detumescence poison is controlled storm wind pain cold air, following food." " Bencao Tujing ": " and control flatulence and puerperal deteriorated blood make a psychological attack." supplement to the Herbal: " and the acrid in the mouth temperature, nontoxic." Compendium of Material Medica: " control the migratory arthralgia brachialgia." Fructus Liquidambaris, Semen Sinapis, windproof, Rhizoma Curcumae Longae removing obstruction in the collateral to relieve pain.
Above compatibility of drugs is played reinforcing the kidney and supporting YANG altogether, benefiting QI for activating blood circulation, and the effect of removing obstruction in the collateral to relieve pain is applicable to cervical spondylotic radiculopathy, belongs to deficiency of the liver and kindey, Qi deficiency blood stasis type.Treatment " caused by liver and kidney deficiency, qi and blood deficiency " CSR obtains better curative effect clinically.Have also simultaneously that drug loading is big, few side effects, advantage such as easy to carry, development and application has a extensive future.
Chinese medicine ability reinforcing the kidney and supporting YANG of the present invention, benefiting QI for activating blood circulation, removing obstruction in the collateral to relieve pain, convenient in application, determined curative effect.
The specific embodiment
Embodiment 1
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 10g, Radix Astragali 15g, Cortex Eucommiae 9g, Radix Paeoniae Alba 13g, Cortex Cinnamomi 4g, Fructus Liquidambaris 7g, Semen Sinapis 7g, Flos Carthami 9g, windproof 9g, Rhizoma Curcumae Longae 7g.
Preparation technology:
(1) Cornu Cervi decocte with water, decocte with water 3 times adds the water of 8 times of medicine gross masses at every turn, decocts 2.5 hours at every turn, filters, and being concentrated into relative density is the condensed cream of 1.09 (70 ℃);
(2) with Cortex Cinnamomi, Semen Sinapis, windproof, water that Rhizoma Curcumae Longae adds 3 times of its quality, distillating extracting oil, 6 hours extraction times, volatile oil is with the beta-schardinger dextrin-inclusion; Medicinal residues are deposited in addition, and combining medicine is in (4) decocting liquid; The inclusion of volatile oil is for the beta-schardinger dextrin-of 10 times of quality of volatile oil, and the water that adds 2.5 times of beta-schardinger dextrin-quality grinds well, and the back drips volatile oil, grinds to form pasty state again, 45 ℃ of dryings of inclusion complex, and porphyrize gets the beta-cyclo dextrin included compound of volatile oil.
(4) with the Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water 2 times adds the water of 10 times of medicine gross masses at every turn, decocts 1.5 hours at every turn; Filter; Filtrating and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and being concentrated into relative density is the concentrated solution of 1.12 (60 ℃), is water drug-decocting concentrating liquid;
(5) stir adding 95% (V/V) ethanol in the water drug-decocting concentrating liquid, addition is that 1.5 times (m/m) of concentrated solution quality staticly settle and filter, with filtrate recycling ethanol and be concentrated into the condensed cream that relative density is 1.20 (70 ℃);
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add dextrin and stir, the addition of dextrin is 0.3 times of spray drying of condensed cream solid content;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, stevioside mix homogeneously, the stevioside addition is 0.2% of a spray-dired medicated powder quality, dry granulation.
Embodiment 2
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 12g, Radix Astragali 25g, Cortex Eucommiae 12g, Radix Paeoniae Alba 18g, Cortex Cinnamomi 6g, Fructus Liquidambaris 9g, Semen Sinapis 10g, Flos Carthami 12g, windproof 12g, Rhizoma Curcumae Longae 12g.
Preparation technology:
(1) Cornu Cervi decocte with water, decocte with water 4 times adds the water of 20 times of medicine gross masses at every turn, decocts 3 hours at every turn, filters, and being concentrated into relative density is the condensed cream of 1.20 (50 ℃);
(2) with Cortex Cinnamomi, Semen Sinapis, windproof, water that Rhizoma Curcumae Longae adds 6 times of its quality, distillating extracting oil, 8 hours extraction times, volatile oil is with the beta-schardinger dextrin-inclusion; Medicinal residues are deposited in addition, and combining medicine is in (4) decocting liquid; The inclusion of volatile oil is for the beta-schardinger dextrin-of 12 times of quality of volatile oil, and the water that adds 2.5 times of beta-schardinger dextrin-quality grinds well, and the back drips volatile oil, grinds to form pasty state again, 50 ℃ of dryings of inclusion complex, and porphyrize gets the beta-cyclo dextrin included compound of volatile oil.
(4) with the Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water 3 times adds the water of 12 times of medicine gross masses at every turn, decocts 2 hours at every turn; Filter; Filtrating and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and being concentrated into relative density is the concentrated solution of 1.15 (50 ℃), is water drug-decocting concentrating liquid;
(5) stir adding 95% (V/V) ethanol in the water drug-decocting concentrating liquid, addition is that 2 times (m/m) of concentrated solution quality staticly settle and filter, with filtrate recycling ethanol and be concentrated into the condensed cream that relative density is 1.22 (50 ℃);
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add dextrin and stir, the addition of dextrin is 0.2 times of spray drying of condensed cream solid content;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, stevioside mix homogeneously, the stevioside addition is 0.4% of a spray-dired medicated powder quality, dry granulation.
Embodiment 3
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 11g, Radix Astragali 20g, Cortex Eucommiae 10g, Radix Paeoniae Alba 15g, Cortex Cinnamomi 5g, Fructus Liquidambaris 8g, Semen Sinapis 8g, Flos Carthami 10g, windproof 10g, Rhizoma Curcumae Longae 8g.
Preparation technology:
(1) Cornu Cervi decocte with water, decocte with water 3 times adds the water of 10 times of medicine gross masses at every turn, decocts 2 hours at every turn, filters, and being concentrated into relative density is the condensed cream of 1.10 (65 ℃);
(2) with Cortex Cinnamomi, Semen Sinapis, windproof, water that Rhizoma Curcumae Longae adds 4 times of its quality, distillating extracting oil, 6 hours extraction times, volatile oil is with the beta-schardinger dextrin-inclusion; Medicinal residues are deposited in addition, and combining medicine is in (4) decocting liquid; The inclusion of volatile oil is for the beta-schardinger dextrin-of 9 times of quality of volatile oil, and the water that adds 2 times of beta-schardinger dextrin-quality grinds well, and the back drips volatile oil, grinds to form pasty state again, 45 ℃ of dryings of inclusion complex, and porphyrize gets the beta-cyclo dextrin included compound of volatile oil.
(4) with the Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water 2 times adds the water of 8 times of medicine gross masses at every turn, decocts 1.5 hours at every turn; Filter; Filtrating and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and being concentrated into relative density is the concentrated solution of 1.10 (65 ℃), is water drug-decocting concentrating liquid;
(5) stir adding 95% (V/V) ethanol in the water drug-decocting concentrating liquid, addition is that 1.5 times (m/m) of concentrated solution quality staticly settle and filter, with filtrate recycling ethanol and be concentrated into the condensed cream that relative density is 1.12 (70 ℃);
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add dextrin and stir, the addition of dextrin is 0.5 times of spray drying of condensed cream solid content;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, stevioside mix homogeneously, the stevioside addition is 0.3% of a spray-dired medicated powder quality, dry granulation.
Embodiment 4
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 8g, Radix Astragali 12g, Cortex Eucommiae 8g, Radix Paeoniae Alba 12g, Cortex Cinnamomi 3g, Fructus Liquidambaris 7g, Semen Sinapis 6g, Flos Carthami 8g, windproof 8g, Rhizoma Curcumae Longae 6g.
Preparation technology:
(1) Cornu Cervi decocte with water, decocte with water 2 times adds the water of 6 times of medicine gross masses at every turn, decocts 1 hour at every turn, filters, and being concentrated into relative density is the condensed cream of 1.05 (80 ℃);
(2) with Cortex Cinnamomi, Semen Sinapis, windproof, water that Rhizoma Curcumae Longae adds 3 times of its quality, distillating extracting oil, 4 hours extraction times, volatile oil is with the beta-schardinger dextrin-inclusion; Medicinal residues are deposited in addition, and combining medicine is in (4) decocting liquid; The inclusion of volatile oil is for the beta-schardinger dextrin-of 5 times of quality of volatile oil, and the water that adds 2 times of beta-schardinger dextrin-quality grinds well, and the back drips volatile oil, grinds to form pasty state again, 40 ℃ of dryings of inclusion complex, and porphyrize gets the beta-cyclo dextrin included compound of volatile oil.
(4) with the Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water 2 times adds the water of 6 times of medicine gross masses at every turn, decocts 1 hour at every turn; Filter; Filtrating and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and being concentrated into relative density is the concentrated solution of 1.05 (80 ℃), is water drug-decocting concentrating liquid;
(5) stir adding 95% (V/V) ethanol in the water drug-decocting concentrating liquid, addition is that 1.5 times (m/m) of concentrated solution quality staticly settle and filter, with filtrate recycling ethanol and be concentrated into the condensed cream that relative density is 1.10 (80 ℃);
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add dextrin and stir, the addition of dextrin is 0.8 times of condensed cream solid content, spray drying;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, stevioside mix homogeneously, the stevioside addition is 0.1% of a spray-dired medicated powder quality, dry granulation.
Embodiment 5
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 15g, Radix Astragali 30g, Cortex Eucommiae 15g, Radix Paeoniae Alba 20g, Cortex Cinnamomi 9g, Fructus Liquidambaris 10g, Semen Sinapis 15g, Flos Carthami 15g, windproof 15g, Rhizoma Curcumae Longae 15g.
Preparation technology:
(1) Cornu Cervi decocte with water, decocte with water 3 times adds the water of 10 times of medicine gross masses at every turn, decocts 2.5 hours at every turn, filters, and being concentrated into relative density is the condensed cream of 1.12 (75 ℃);
(2) with Cortex Cinnamomi, Semen Sinapis, windproof, water that Rhizoma Curcumae Longae adds 3.5 times of its quality, distillating extracting oil, 7 hours extraction times, volatile oil is with the beta-schardinger dextrin-inclusion; Medicinal residues are deposited in addition, and combining medicine is in (4) decocting liquid; The inclusion of volatile oil is for the beta-schardinger dextrin-of 8 times of quality of volatile oil, and the water that adds 2 times of beta-schardinger dextrin-quality grinds well, and the back drips volatile oil, grinds to form pasty state again, 45 ℃ of dryings of inclusion complex, and porphyrize gets the beta-cyclo dextrin included compound of volatile oil.
(4) with the Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water 2 times adds the water of 8 times of medicine gross masses at every turn, decocts 2 hours at every turn; Filter; Filtrating and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and being concentrated into relative density is the concentrated solution of 1.10 (65 ℃), is water drug-decocting concentrating liquid;
(5) stir adding 95% (V/V) ethanol in the water drug-decocting concentrating liquid, addition is that 1.5 times (m/m) of concentrated solution quality staticly settle and filter, with filtrate recycling ethanol and be concentrated into the condensed cream that relative density is 1.12 (70 ℃);
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add dextrin and stir, the addition of dextrin is 0.6 times of spray drying of condensed cream solid content;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, stevioside mix homogeneously, the stevioside addition is 0.3% of a spray-dired medicated powder quality, dry granulation.
Embodiment 6
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 6g, Radix Astragali 10g, Cortex Eucommiae 6g, Radix Paeoniae Alba 10g, Cortex Cinnamomi 2g, Fructus Liquidambaris 6g, Semen Sinapis 5g, Flos Carthami 6g, windproof 6g, Rhizoma Curcumae Longae 5g.
Preparation technology is with embodiment 1.
Embodiment 7
A kind of Chinese medicine of treating cervical spondylosis, its weight part ratio consists of: Cornu Cervi 20g, Radix Astragali 40g, Cortex Eucommiae 20g, Radix Paeoniae Alba 25g, Cortex Cinnamomi 10g, Fructus Liquidambaris 15g, Semen Sinapis 20g, Flos Carthami 20g, windproof 20g, Rhizoma Curcumae Longae 20g.
Preparation technology is with embodiment 2.
Combine the therapeutical effect of cervical spondylosis animal model that its beneficial effect is described through medicine of the present invention to sound power below.
One. zoopery
1. sound power combines the preparation of cervical spondylosis animal model
Wistar strain rat; Be divided into sound power and combine cervical spondylosis animal model group and sham operated rats; Sound power combines cervical spondylosis model group rat anesthesia tailing edge nape portion median incision, vertically cuts skin and subcutaneous tissue 2～2.5cm, cuts deep fascia and exposes the musculi colli layer; Cut off shallow crowd's flesh earlier, comprise platysma, neck trapezius muscle, head and neck rhomboideus; Cut off dark muscle group again, comprise cervical region splenius, musculus longissimus (longissimus capitis, atlanto longissimus, longissimus cervicis), iliocostalis cervicis and semispinalis capitis; Excise supraspinal ligament and the interspinal ligaments of C2～C7 at last, skin suture carries out behavioristics's test to rat after the modeling, confirms that sound power combines cervical spondylosis animal model rat modeling success.Sham operated rats is only cut skin and subcutaneous tissue, does not cut off musculi colli, does not also excise supraspinal ligament and the interspinal ligaments of C2～C7, directly skin suture.
2. medication
Rat after the modeling is divided into model group, drug group of the present invention and control drug group.By following method administration: 1. sham operated rats, the sham operated rats rat gives water according to the 10ml/kg volume, totally 15 days.2. model (contrast) is organized, and sound power combines the cervical spondylosis rat model to give water according to the 10ml/kg volume, totally 15 days.3. drug group of the present invention, sound power combine the cervical spondylosis rat model to give the embodiment of the invention 1, embodiment 3, embodiment 5, embodiment 6 respectively, are administered once continuous 15 days every day according to 2.70g/kg.4. control drug group (cervicodynia groups of grains), sound power combine the cervical spondylosis rat model to give cervicodynia granule 2.16g/kg, and be administered once every day, continuous 15 days.The behavioristics of detecting rat behind the medicine changes and pressure pain in foot threshold value change situation.
3. result of the test
1. behavioristics's variation model treated animal time daily shows as right upper extremity in operation back and is close to the front, dare not contact to earth, and toe tightens, and elbow, carpal joint are stiff.Behind the administration 7d, drug group rat elbow joint of the present invention can contact to earth and creep, and model group and cervicodynia groups of grains rat still show as upper limb and be close to the front, dare not contact to earth.Behind the treatment 8d, some rat of drug group of the present invention can be contacted to earth with carpal joint and creeped, and the cervicodynia groups of grains can be contacted to earth with elbow joint and creeped, and model group has individual animal to contact to earth with elbow joint to creep.Behind the treatment 15d, all available carpal joint of drug group rat of the present invention contacts to earth and creeps, and cervicodynia groups of grains part animal can be contacted to earth with carpal joint, and some rat elbow joint of model group can contact to earth and creep, and shows that medicine of the present invention can improve the variation of animal pattern behavioristics aspect.
When 2. pain threshold changes administration 15d with pressing the right front palm central part of tail appearance compressing rat, with rat struggle, pressure when shouting is as the pain threshold of this rat.Experimental result is seen table 1.
Table 1. medicine of the present invention combines the therapeutical effect
of cervical spondylosis animal model to sound power
Annotate: compare with model control group, ###P < 0.001
Table 1 is visible, and pain threshold is model group-cervicodynia groups of grains-drug group-sham operated rats of the present invention and increases progressively trend successively.Statistical procedures shows, compares with model control group, and drug group pain threshold of the present invention has extremely significant difference (P < 0.001), and the raising rate is superior to the cervicodynia groups of grains.
Experimental result demonstrates medicine of the present invention and combines unusual form and the behavioral indicator of cervical spondylosis animal model rat to have a better role to sound power, can improve pain threshold, effectively improves the symptom of cervical spondylosis.
Two. clinical trial
Use Chinese medicine of the present invention 50 routine cervical spondylotic radiculopathyes have been carried out the clinical observation summary, obtained clinical efficacy preferably.Clinical physical data: 50 examples are outpatient service and inpatient, minimum 25 years old of age, maximum 60 years old, 43 years old mean age.
1. diagnostic criteria:
Chinese medical discrimination: primary symptom: root pain, numbness and identical with Radiologic imaging; The person's back distending pain is heavy, soreness and weakness of waist and knees, and legs and feet knot, aversion to cold and cold limbs.Secondary symptoms: more obvious osteoarthritis and / or osteoporosis radiographic evidence; may be associated with headache, vertigo, tinnitus, palpitations, nocturia, Huang white or sallow complexion, poor appetite eat less, shortness of breath, sound and mood , pale tongue, white, weak pulse.Include the case standard in:
Meet tcm diagnosis standard and dialectical person, can include the test case in.
Get rid of the case standard:
The outer pathological changes (like thoracic outlet syndrome, scapulohumeral periarthritis) of cervical vertebra, cervical spinal canal is narrow, cervical vertebra and intraspinal tumor, with the hematopathy of bleeding tendency, tuberculosis of bone and joint, osteomyelitis and senile osteoporosis and the unusual person of serious heart and brain hepatic and renal function.
2. observation index:
Safety observation:
Curative effect observation: relevant symptoms and sign; Picture of the tongue, pulse condition change.
Curative effect determinate standard:
Recovery from illness: symptom and sign integration reduce >=95%, and the X line shows normal;
Produce effects symptom and sign integration reduce >=70%,＜95%, and the demonstration of X line is clearly better;
Effectively: symptom and sign integration reduce >=30%,＜75%, and the X line shows improvement;
Invalid: root property syndrome and sign integration reduce less than 30%, and the X line shows does not have change;
Annotate: computing formula is: [integration before (integration before the treatment-treatment back integration) ÷ treatment] * 100%.
3. Therapeutic Method: for oral administration.With embodiment 1 medicine, 1 time 10 gram, 3 times on the one, 15 days is a course of treatment.
4. therapeutic effect:
Among the 50 routine patients, 34 examples of fully recovering account for 68%; Produce effects 14 examples account for 28%; Invalid 2 examples account for 4%, total effective rate 96%.
Safety indexes detects: in clinical observation, 50 routine patients have been carried out medication front and back routine blood test, routine urinalysis and liver, kidney function test, the result shows the equal no abnormality seen of each item index before and after the 50 routine patient treatments.
Untoward reaction: do not have obviously poison pair effect and untoward reaction.
Claims (7)
1. Chinese medicine of treating cervical spondylosis; It is characterized in that its weight part ratio consists of: Cornu Cervi 6-20 part, Radix Astragali 10-40 part, Cortex Eucommiae 6-20 part, Radix Paeoniae Alba 10-25 part, Cortex Cinnamomi 2-10 part, Fructus Liquidambaris 6-15 part, Semen Sinapis 5-20 part, Flos Carthami 6-20 part, windproof 6-20 part, Rhizoma Curcumae Longae 5-20 part.
2. the Chinese medicine of treatment cervical spondylosis according to claim 1; It is characterized in that its weight part ratio consists of: Cornu Cervi 8-15 part, Radix Astragali 12-30 part, Cortex Eucommiae 8-15 part, Radix Paeoniae Alba 12-20 part, Cortex Cinnamomi 3-9 part, Fructus Liquidambaris 7-10 part, Semen Sinapis 6-15 part, Flos Carthami 8-15 part, windproof 8-15 part, Rhizoma Curcumae Longae 6-15 part.
3. the Chinese medicine of treatment cervical spondylosis according to claim 2; It is characterized in that its weight part ratio consists of: Cornu Cervi 10-12 part, Radix Astragali 15-25 part, Cortex Eucommiae 9-12 part, Radix Paeoniae Alba 13-18 part, Cortex Cinnamomi 4-6 part, Fructus Liquidambaris 7-9 part, Semen Sinapis 7-10 part, Flos Carthami 9-12 part, windproof 9-12 part, Rhizoma Curcumae Longae 7-12 part.
4. the preparation method of Chinese medicine of each described treatment cervical spondylosis of claim 1-3 is characterized in that, comprises the steps:
(1) Cornu Cervi decocte with water filters, and is condensed into condensed cream, and is subsequent use;
(2) Cortex Cinnamomi, Semen Sinapis, windproof, Rhizoma Curcumae Longae are added water distillation and extraction volatile oil, volatile oil is encapsulated with for use with beta-schardinger dextrin-, and medicinal residues are deposited in addition, and combining medicine is in decocting liquid;
(4) with the Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water; Filter, merge, be condensed into water drug-decocting concentrating liquid with Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil;
(5) water drug-decocting concentrating liquid is added ethanol and stir, leave standstill, deposition filters, and filtrate recycling ethanol also is condensed into the water decoction-alcohol sedimentation condensed cream, and is subsequent use;
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add adjuvant and stir spray drying;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, tender flavor agent mix homogeneously, dry granulation.
5. the preparation method of Chinese medicine of treatment cervical spondylosis according to claim 4 is characterized in that, comprises the steps:
(1) with Cornu Cervi decocte with water 2-4 time, add medicine material medicine gross mass 6-20 water doubly at every turn, decocted 1-3 hour at every turn, filter, the condensed cream of 1.05-1.20 when being concentrated into relative density and being 50-80 ℃;
(3) Cortex Cinnamomi, Semen Sinapis, windproof, Rhizoma Curcumae Longae are added its quality 3-6 water doubly, distillating extracting oil, extraction time 4-8 hour, volatile oil was with the beta-schardinger dextrin-inclusion;
(4) Cortex Cinnamomi behind the Radix Astragali, the Cortex Eucommiae, the Radix Paeoniae Alba, Fructus Liquidambaris, Flos Carthami and the extraction volatile oil, Semen Sinapis, windproof, Rhizoma Curcumae Longae medicinal residues merging; Decocte with water 2-3 time adds medicine material medicine gross mass 6-12 water doubly at every turn, decocts 1-2 hour at every turn; Filter; Decocting liquid and Cortex Cinnamomi, Semen Sinapis, water liquid windproof, that Rhizoma Curcumae Longae is extracted behind the volatile oil merge, and the concentrated solution of 1.05-1.15 is water drug-decocting concentrating liquid when being concentrated into relative density and being 50-80 ℃;
(5) be that 95% ethanol stirs with adding volumetric concentration in the water drug-decocting concentrating liquid, addition is that the 1.5-2 of concentrated solution quality doubly staticly settles and filters, the condensed cream of 1.10-1.22 with filtrate recycling ethanol and when being concentrated into relative density and being 50-80 ℃;
(6) (1) condensed cream and (5) condensed cream are merged, mixing is for mixing condensed cream;
(7) in (6) mixing condensed cream, add adjuvant and stir spray drying;
(8) with spray-dired medicated powder and Cortex Cinnamomi, Semen Sinapis, windproof, the beta-cyclo dextrin included compound of Rhizoma Curcumae Longae volatile oil, tender flavor agent mix homogeneously, dry granulation.
6. according to the preparation method of Chinese medicine of claim 4 or 5 described treatment cervical spondylosiss, it is characterized in that the described adjuvant addition of step (7) is 0.2-0.8 times of mixing condensed cream solid content.
7. according to the preparation method of Chinese medicine of claim 4 or 5 described treatment cervical spondylosiss, it is characterized in that the described tender flavor agent addition of step (8) is the 0.1-0.4% of spray-dired medicated powder quality.
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