CN101385818B - Pregnant aid preparation for treating sterility due to inadequate luteal function and preparation method thereof - Google Patents
Pregnant aid preparation for treating sterility due to inadequate luteal function and preparation method thereof Download PDFInfo
- Publication number
- CN101385818B CN101385818B CN2008101519744A CN200810151974A CN101385818B CN 101385818 B CN101385818 B CN 101385818B CN 2008101519744 A CN2008101519744 A CN 2008101519744A CN 200810151974 A CN200810151974 A CN 200810151974A CN 101385818 B CN101385818 B CN 101385818B
- Authority
- CN
- China
- Prior art keywords
- preparation
- parts
- radix
- infertility
- pregnancy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a proconceptive preparation for treating infertility caused by inadequate luteal function and a preparation method thereof. The proconceptive preparation is made from the following dosages by weight proportions: 50-150 parts of morinda officinalis (prepared), 80-220 parts of malaytea scurfpea, 140-260 parts of dodder, 25-35 parts of deerhorn glue, 70-130 parts of angelica,60-140 parts of motherwort, 120-380 parts of astragalus root, 90-110 parts of rehmannia root, 60-140 parts of aucklandia root, 100-200 parts of nutgrass galingale rhizome (prepared), 55-105 parts of baikal skullcap root and 50-100 parts of notopterygium root. The active components of the proconceptive preparation are extracted by a boiling-water-extraction method, and kept the activity of the preparation, thus greatly improving the dissolution of the active components in the drugs, being helpful of the absorption of the drug and improving the bioavailability thereof. In addition, the proconceptive preparation is a pure Chinese materia medica preparation, and toxic and side effect can not be caused after being used for a long time by patients, so the proconceptive preparation has high safety.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relate to pregnancy-assisting formulation of the infertility that a kind of treatment inadequate luteal function that with Chinese medicine is raw material is made causes and preparation method thereof.
Background technology
Infertility is a kind of common clinical, and all woman are not contraception after marriage, and the normality life is arranged, and lived together 2 years, and the person of not becoming pregnant is called primary infertility; Or gestation was once arranged, and not contraception then, the disease that the person suffered from of becoming pregnant again was called secondary infertility in continuous again 2 years.Patient's inadequate luteal function can cause the secretory endometrium dysplasia, thereby causes cytula to be difficult for implantation and infertile.Not only kind is few to be used for the treatment of at present the Chinese patent medicine of infertility clinically, and specific aim is not strong, so belong to inadequate luteal function and the DeGrain of this disease of infertility that causes for treatment.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of infertility effect for the treatment of inadequate luteal function and causing obvious, thereby with strong points, and the pregnancy-assisting formulation of the infertility that causes of the treatment inadequate luteal function that has no side effect.
Another object of the present invention is to provide a kind of method that is used to prepare above-mentioned pregnancy-assisting formulation.
In order to achieve the above object, the pregnancy-assisting formulation of the infertility that causes of treatment inadequate luteal function provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Radix Morindae Officinalis (system) 50-150 Fructus Psoraleaes 80-220 Semen Cuscutae 140-260
Colla cornus cervi 25-35 Radix Angelicae Sinensis 70-130 Herba Leonuris 60-140
The Radix Astragali 120-380 Radix Rehmanniae 90-110 Radix Aucklandiae 60-140
Rhizoma Cyperi (system) 100-200 Radix Scutellariaes 55-105 Rhizoma Et Radix Notopterygiis 50-100
The preparation method of the pregnancy-assisting formulation of the infertility that described treatment inadequate luteal function causes is to carry out according to the following step order:
A. the said medicine raw material is carried out weighing according to proportioning, will decoct with water 2 times after the 11 herbal medicine raw materials mixing except that Colla cornus cervi then, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
B. in above-mentioned thick paste, add Colla cornus cervi, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
The pregnancy-assisting formulation of the infertility that treatment inadequate luteal function provided by the invention causes is that the method for employing decocting in water extraction is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
This side is set for the married woman improves luteal function.The salty tepor of Colla cornus cervi in the side, but kidney-replenishing, tonifying YIN blood has stronger anastalsis again.Semen Cuscutae Xin Ganping, but both YANG invigorating, but tonifying YIN again; The hot sweet tepor of Radix Morindae Officinalis, reinforcing the kidney and supporting YANG, strengthening the tendons and bones; The arduous temperature of Fructus Psoraleae, promptly kidney-replenishing is needle warming moxibustion again, more than four medicines share kidney and spleen invigorating, be monarch drug altogether.The sweet tepor of the Radix Astragali, tonifying Qi and lifting yang is the key medicine of invigorating the spleen and benefiting QI; Radix Angelicae Sinensis Gan Xinwen, benefiting blood and regulating blood circulation; Herba Leonuri is arduous to be slightly cold, and blood circulation promoting and blood stasis dispelling is the key medicine of gynecological's multiparity; Radix Rehmanniae sweetness and bitterness is cold, clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, more than four medicines share, but nourishing blood to promote the production of body fluid is thought ministerial drug.The arduous temperature of the Radix Aucklandiae, soothing the liver circulation of qi promoting; Rhizoma Cyperi is arduous flat, regulating QI to promote menstruation, the Radix Scutellariae bitter cold, heat clearing and damp drying, more than three medicines be to be adjuvant drug.The arduous temperature of Rhizoma Et Radix Notopterygii is dispersed pain relieving, is messenger drug.
Pregnancy-assisting formulation of the infertility that treatment inadequate luteal function provided by the invention is caused below in conjunction with embodiment and preparation method thereof is elaborated.
Embodiment 1:
The pregnancy-assisting formulation of the infertility that the treatment inadequate luteal function in the present embodiment causes is that the following medicine material of weight ratio is made by consumption mainly:
Radix Morindae Officinalis (system) 100 Fructus Psoraleaes 150 Semen Cuscutae 200
Colla cornus cervi 30 Radix Angelicae Sinensis 100 Herba Leonuris 100
The Radix Astragali 200 Radix Rehmanniae 100 Radix Aucklandiae 100
Rhizoma Cyperi (system) 150 Radix Scutellariaes 80 Rhizoma Et Radix Notopterygiis 80
Preparation method:
A. the said medicine raw material is carried out weighing according to proportioning, will decoct with water 2 times after the 11 herbal medicine raw materials mixing except that Colla cornus cervi then, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
B. in above-mentioned thick paste, add Colla cornus cervi, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
The pregnancy-assisting formulation of the infertility that the treatment inadequate luteal function in the present embodiment causes is that the following medicine material of weight ratio is made by consumption mainly:
Radix Morindae Officinalis (system) 50 Fructus Psoraleaes 80 Semen Cuscutae 140
Colla cornus cervi 25 Radix Angelicae Sinensis 70 Herba Leonuris 60
The Radix Astragali 120 Radix Rehmanniae 90 Radix Aucklandiae 60
Rhizoma Cyperi (system) 100 Radix Scutellariaes 55 Rhizoma Et Radix Notopterygiis 50
Preparation method is with embodiment 1.
Embodiment 3:
The pregnancy-assisting formulation of the infertility that the treatment inadequate luteal function in the present embodiment causes is that the following medicine material of weight ratio is made by consumption mainly:
Radix Morindae Officinalis (system) 150 Fructus Psoraleaes 220 Semen Cuscutae 260
Colla cornus cervi 35 Radix Angelicae Sinensis 130 Herba Leonuris 140
The Radix Astragali 380 Radix Rehmanniae 110 Radix Aucklandiae 140
Rhizoma Cyperi (system) 200 Radix Scutellariaes 105 Rhizoma Et Radix Notopterygiis 100
Preparation method is with embodiment 1.
The pregnancy-assisting formulation of the infertility that treatment inadequate luteal function provided by the invention causes is brown to sepia, mildly bitter flavor.In order to verify the therapeutic effect of this pregnancy-assisting formulation, the infertility patient that the inventor utilizes the capsule that belongs to oral solid formulation in the above-mentioned pregnancy-assisting formulation that 584 examples are suffered from inadequate luteal function has carried out system's clinical observation, 21-30 year patient's 214 examples wherein, 31-40 year patient's 278 examples, 41-50 year patient's 92 examples, 3 of each medications, every day 2 times.After 1 course of therapy, cure (cardinal symptom disappears, and conceived) 21 examples, account for 3.6%; Produce effects (cardinal symptom disappears, but fail pregnancy) 207 examples account for 35.4%; Effectively (cardinal symptom obviously alleviates) 259 examples account for 44.3%; Invalid (cardinal symptom does not have significant change) 97 examples account for 16.6%; Total effective rate is 83.4%.After 2 course of therapy, cure 73 examples altogether, account for 12.5%; Produce effects 197 examples account for 33.7%; Effectively account for 244 examples, account for 41.8%; Invalid 70 examples account for 12.0%; Total effective rate is 88.0%.
Simultaneously, the inventor analyzes curative effect and age, curative effect and the relation between the course of treatment, and analysis result sees Table 1 respectively, table 2.
Table 1: pregnancy-assisting formulation therapeutic effect provided by the invention and age relation table
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is 0.050〉P〉0.025, can prove that thus taking pregnancy-assisting formulation provided by the invention treats the infertility that inadequate luteal function causes, and the therapeutic effect of each age group is not changed with the age.
Table 2: pregnancy-assisting formulation therapeutic effect provided by the invention and the course of treatment relation table
With the data x in the above-mentioned table 2
2Method of inspection calculates, and the result is P＜0.005, can prove that thus taking pregnancy-assisting formulation provided by the invention treats the infertility that inadequate luteal function causes, and along with going deep into of treatment, cure rate, obvious effective rate and effective percentage all obviously improve.
Claims (2)
1. pregnancy-assisting formulation for the treatment of the infertility that inadequate luteal function causes is characterized in that: the pregnancy-assisting formulation of the infertility that described treatment inadequate luteal function causes is that the following medicine material of weight ratio is made by consumption:
Radix Morindae Officinalis (processed) 50-150 Fructus Psoraleae 80-220 Semen Cuscutae 140-260
Colla cornus cervi 25-35 Radix Angelicae Sinensis 70-130 Herba Leonuri 60-140
Radix Astragali 120-380 Radix Rehmanniae 90-110 Radix Aucklandiae 60-140
Rhizoma Cyperi (processed) 100-200 Radix Scutellariae 55-105 Rhizoma Et Radix Notopterygii 50-100.
2. the preparation method of the pregnancy-assisting formulation of the infertility that causes of a treatment inadequate luteal function as claimed in claim 1, it is characterized in that: the preparation method of the pregnancy-assisting formulation of the infertility that described treatment inadequate luteal function causes is to carry out according to the following step order:
A. the said medicine raw material is carried out weighing according to proportioning, will decoct with water 2 times after the 11 herbal medicine raw materials mixing except that Colla cornus cervi then, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
B. in above-mentioned thick paste, add Colla cornus cervi, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519744A CN101385818B (en) | 2008-09-28 | 2008-09-28 | Pregnant aid preparation for treating sterility due to inadequate luteal function and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519744A CN101385818B (en) | 2008-09-28 | 2008-09-28 | Pregnant aid preparation for treating sterility due to inadequate luteal function and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101385818A CN101385818A (en) | 2009-03-18 |
| CN101385818B true CN101385818B (en) | 2011-06-15 |
Family
ID=40475624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101519744A Expired - Fee Related CN101385818B (en) | 2008-09-28 | 2008-09-28 | Pregnant aid preparation for treating sterility due to inadequate luteal function and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101385818B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101554440B (en) * | 2009-05-18 | 2011-12-28 | 高全旺 | Pharmaceutical composition and preparation method thereof |
| CN102085269B (en) * | 2011-01-28 | 2012-02-22 | 浙江大学 | Traditional Chinese medicine composition for treating polycystic ovary syndrome (PCOS) and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053620A (en) * | 2007-05-16 | 2007-10-17 | 北京艺信堂医药研究所 | Traditional Chinese medicine preparations for treating luteal phase defect sterility |
| CN101152392A (en) * | 2007-09-24 | 2008-04-02 | 雷兴福 | Traditional Chinese medicine composition for treating women's barrenness |
-
2008
- 2008-09-28 CN CN2008101519744A patent/CN101385818B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101053620A (en) * | 2007-05-16 | 2007-10-17 | 北京艺信堂医药研究所 | Traditional Chinese medicine preparations for treating luteal phase defect sterility |
| CN101152392A (en) * | 2007-09-24 | 2008-04-02 | 雷兴福 | Traditional Chinese medicine composition for treating women's barrenness |
Non-Patent Citations (1)
| Title |
|---|
| 温丽娜等.《黄体功能不全性不孕症的临床及实验研究进展》.《辽宁中医药大学学报》.2008,第10卷(第2期),第82-83页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101385818A (en) | 2009-03-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101380440A (en) | Use of Yunkang oral liquid in preparing medicine for treating kidney-deficiency type sterility | |
| CN102188583A (en) | Traditional Chinese medicine for treating infertility | |
| CN102120020B (en) | Medicinal composition for treating hyperplastic diseases of breast and hysteromyoma and preparation method thereof | |
| CN101961458B (en) | Oral medicament for treating osteonecrosis of femoral head | |
| CN101385818B (en) | Pregnant aid preparation for treating sterility due to inadequate luteal function and preparation method thereof | |
| CN101376014B (en) | Pregnancy-assisting formulation for treating infertility induced by dysfunctional ovulation and its preparation method | |
| CN102648969B (en) | Complex Chinese medicine preparation for reinforcing kidney | |
| CN105999058B (en) | Bidens bipinnata lipid-lowering tablet | |
| CN104258359A (en) | Traditional Chinese medicine combination for curing pregnancy reaction and preparation method of preparations thereof | |
| CN101278996A (en) | Medicament compound for curing sciatica and method of preparing the same | |
| CN106266431A (en) | Wind-damp dispelling is good for pharmaceutical composition, preparation that kidney lengthens one's life and preparation method thereof | |
| CN102349979A (en) | Oral traditional Chinese medicine composition for treating bitter taste in mouth | |
| CN101375955B (en) | Sperm-passing formulation for treating non-ejaculation symptom and preparation method thereof | |
| CN101721669A (en) | Traditional Chinese medicine composition for treating cold dampness type sciatica | |
| CN101455755B (en) | Yang-strengthening preparation for treating yang-insufficiency type impotence and preparation method thereof | |
| CN1083269C (en) | Chinese herbal medicine for treating hysteromyoma and breast fibrosarcoma and its prepn. method | |
| CN101376010B (en) | Vigor formulation for producing sperm for treating asthenospermia and preparation method thereof | |
| CN102357179B (en) | Medicine for treating antisperm antibody induced infertility or habitual abortion and preparation method thereof | |
| CN101375987B (en) | Anti-inflammation formulation for treating chronic prostatitis and preparation method thereof | |
| CN105853712A (en) | Traditional Chinese medicine composition for treating ophthalmic diseases | |
| CN105709117A (en) | Traditional Chinese medicine composition containing argy wormwood leaves and used for female kidney-yang deficiency type ovulation failure | |
| CN105055818A (en) | Pharmaceutical preparation for treating neurodermatitis | |
| CN101376012B (en) | Formulation for treating abnormal sperm symptom, eliminating abnormal sperm and producing sperm, as well as preparation method thereof | |
| CN101376013B (en) | Formulation for treating dysmenorrhea and regulating menstruation, and preparation method thereof | |
| CN101376015B (en) | Sperm-stopping formulation for treating spermatorrhea and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170606 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110615 Termination date: 20210928 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |