CN101376010B - Vigor formulation for producing sperm for treating asthenospermia and preparation method thereof - Google Patents
Vigor formulation for producing sperm for treating asthenospermia and preparation method thereof Download PDFInfo
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- CN101376010B CN101376010B CN2008101519123A CN200810151912A CN101376010B CN 101376010 B CN101376010 B CN 101376010B CN 2008101519123 A CN2008101519123 A CN 2008101519123A CN 200810151912 A CN200810151912 A CN 200810151912A CN 101376010 B CN101376010 B CN 101376010B
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Abstract
The invention relates to a preparation with spermatogenic effect for treating oligospermia, and a preparation method thereof. The preparation is prepared from the following materials (by weight part): air bladder of Pseudosciaena crocea and/or Pseudosciaena polyactis 90-150, processed Rehmannia glutinosa 70-95, Cinnamomum cassia bark 25-35, Cinnamomum cassia twig 3-8, Lycium barbarum fruit 60-120, Cornus officinalis 40-80, Dioscorea opposita 70-140, Fructus Amomi 20-50, Cuscuta chinensis seed 40-80, Astragalus membranaceus 70-110, Angelica sinensis 20-45, Broussonetia papyrifera fruit 40-90, Morinda officinalis (processed) 50-70, Paeonia suffruticosa bark 30-40, Oldenlandia diffusa 100-140, and Achyranthes bidentata 20-35. The effective ingredients of the raw materials in the preparation are extracted by decoction, and activities thereof are remained, so as to remarkably improve the dissolution rate, promote absorption of the effective ingredients, and improve bioavailability. In addition, the preparation is a pure Chinese medicinal preparation, thereby resulting in good safety and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relate to a kind of with Chinese medicine be raw material make be used for the treatment of vigor spermatogenesis preparation of azoospermia and preparation method thereof.
Background technology
Medically with the sperm that travels forward in the seminal parameters (a+b level) toatl proportion less than 50%, or the disease of the sperm that travels forward fast (a level) less than 25% is called azoospermia.The types of drugs that is used for the treatment of at present azoospermia clinically very little, specific aim is not strong yet, and the toxic and side effects of some medicine is big, so take back DeGrain for treatment belongs to this disease of kidney yang deficiency syndrome azoospermia.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of treatment kidney yang deficiency syndrome azoospermia effect obvious, thereby with strong points, and the vigor spermatogenesis preparation that is used for the treatment of azoospermia that has no side effect.
Another object of the present invention is to provide a kind of method that is used to prepare above-mentioned vigor spermatogenesis preparation.
In order to achieve the above object, the vigor spermatogenesis preparation that is used for the treatment of azoospermia provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Air Bladder pseudosciaenae seu Acipenser 90-150 Radix Rehmanniae Preparata 70-95 Cortex Cinnamomis 25-35
Ramulus Cinnamomi 3-8 Fructus Lycii 60-120 Fructus Corni 40-80
Rhizoma Dioscoreae 70-140 Fructus Amomis 20-50 Semen Cuscutae 40-80
The Radix Astragali 70-110 Radix Angelicae Sinensis 20-45 Fructus Broussonetiaes 40-90
Radix Morindae Officinalis (system) 50-70 Cortex Moutans 30-40 Herba Hedyotidis Diffusaes 100-140
Radix Achyranthis Bidentatae 20-35
The described preparation method that is used for the treatment of the vigor spermatogenesis preparation of azoospermia is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then Rhizoma Dioscoreae, Ramulus Cinnamomi, Fructus Amomi, each 1/3rd amount of Cortex Moutan are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Rhizoma Dioscoreae, Ramulus Cinnamomi, Fructus Amomi, 12 kinds of medicine materials of Cortex Moutan and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
The vigor spermatogenesis preparation that is used for the treatment of azoospermia provided by the invention is that the method for employing decocting in water extraction is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
It is one of major reason that causes masculine sterility that motility of sperm descends.The traditional Chinese medical science thinks, this disease is many by the natural endowment deficiency, or eipathia asthenia, or excess of sexual intercourse, causes deficiency of kidney-essence, deficiency of kidney-YIN, decline of the fire from the gate of life, can not warm kidney in essential substance for reproduction, due to the weary source of spermatozoon power.So treatment is worked as with kidney invigorating and YANG supporting.Air Bladder pseudosciaenae seu Acipenser is salty in the side is slightly cold, and is the in love product of flesh and blood, big replenishing vital essence and blood; The sweet tepor of Radix Rehmanniae Preparata is product on the YIN nourishing of enriching blood; Ramulus Cinnamomi, Cortex Cinnamomi two flavors are hot using warming therapy product, and warming the meridian for promoting the flow of YANG QI can be inspired yang-energy, thus can strengthen motility of sperm, more than four medicines be monarch drug altogether.Fructus Lycii is sweet flat, nourishing YIN and supplementing blood; Semen Cuscutae is sweet flat, but both tonifying YIN, but YANG invigorating again; Fructus Broussonetiae is sweet flat, the liver and the kidney tonifying, and three sons are with the meaning of " mending son with son " in order to residence.The sweet temperature of urosolic acid, nourishing the liver and kidney, controlling nocturnal emission with astringent drugs arresting seminal emission; The hot sweet tepor of Radix Morindae Officinalis, reinforcing the kidney and supporting YANG, strengthening the tendons and bones; The sweet tepor of the Radix Astragali, tonifying Qi and lifting yang; The sweet temperature of Radix Angelicae Sinensis is enriched blood and is invigorated blood circulation; Rhizoma Dioscoreae is sweet flat, the spleen reinforcing kidney; The hot temperature of Fructus Amomi, the kidney tonifying of being amusing, the taste that also can make tonic is greasy.Medicine-feeding is share, but kidney and spleen invigorating to help the sperm the source of vital function, is to be ministerial drug.The Cortex Moutan suffering is slightly cold, removing heat from blood and blood; Herba Hedyotidis Diffusae is sweet cold, heat clearing and blood circulation promoting, and the same usefulness of two medicines both can make the tonic tonify without causing stagnation, can remove the dry strong of a large amount of temperature compensations again, and be adjuvant drug.The Radix Achyranthis Bidentatae suffering is slightly cold, blood circulation promoting and blood stasis dispelling, and priming is descending, thinks messenger drug.
Below in conjunction with embodiment vigor spermatogenesis preparation that is used for the treatment of azoospermia provided by the invention and preparation method thereof is elaborated.
Embodiment 1:
The vigor spermatogenesis preparation that is used for the treatment of azoospermia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Air Bladder pseudosciaenae seu Acipenser 120 Radix Rehmanniae Preparata 90 Cortex Cinnamomis 30
Ramulus Cinnamomi 4 Fructus Lycii 90 Fructus Corni 60
Rhizoma Dioscoreae 90 Fructus Amomis 30 Semen Cuscutae 60
The Radix Astragali 90 Radix Angelicae Sinensis 30 Fructus Broussonetiaes 60
Radix Morindae Officinalis (system) 60 Cortex Moutans 30 Herba Hedyotidis Diffusaes 120
Radix Achyranthis Bidentatae 30
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, then Rhizoma Dioscoreae, Ramulus Cinnamomi, Fructus Amomi, each 1/3rd amount of Cortex Moutan are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Rhizoma Dioscoreae, Ramulus Cinnamomi, Fructus Amomi, 12 kinds of medicine materials of Cortex Moutan and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
The vigor spermatogenesis preparation that is used for the treatment of azoospermia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Air Bladder pseudosciaenae seu Acipenser 90 Radix Rehmanniae Preparata 70 Cortex Cinnamomis 25
Ramulus Cinnamomi 3 Fructus Lycii 60 Fructus Corni 40
Rhizoma Dioscoreae 70 Fructus Amomis 20 Semen Cuscutae 40
The Radix Astragali 70 Radix Angelicae Sinensis 20 Fructus Broussonetiaes 40
Radix Morindae Officinalis (system) 50 Cortex Moutans 30 Herba Hedyotidis Diffusaes 100
Radix Achyranthis Bidentatae 20
Preparation method is with embodiment 1.
Embodiment 3:
The vigor spermatogenesis preparation that is used for the treatment of azoospermia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Air Bladder pseudosciaenae seu Acipenser 150 Radix Rehmanniae Preparata 95 Cortex Cinnamomis 35
Ramulus Cinnamomi 8 Fructus Lycii 120 Fructus Corni 80
Rhizoma Dioscoreae 140 Fructus Amomis 50 Semen Cuscutae 80
The Radix Astragali 110 Radix Angelicae Sinensis 45 Fructus Broussonetiaes 90
Radix Morindae Officinalis (system) 70 Cortex Moutans 40 Herba Hedyotidis Diffusaes 140
Radix Achyranthis Bidentatae 35
Preparation method is with embodiment 1.
The vigor spermatogenesis preparation that is used for the treatment of azoospermia provided by the invention is brown to sepia; The feeble QI raw meat.In order to verify the therapeutic effect of this vigor spermatogenesis preparation, the patient that the inventor utilizes the capsule that belongs to oral solid formulation in the above-mentioned vigor spermatogenesis preparation that 247 examples are suffered from the kidney yang deficiency syndrome azoospermia has carried out system's clinical observation, 21-30 year patient's 95 examples wherein, 31-40 year patient's 113 examples, 41-50 year patient's 39 examples, 3 of each medications, every day 2 times, 70 days is 1 course of treatment.After 1 course of therapy, cure (a+b level sperm 〉=50% or a level sperm 〉=25%, and wife's side pregnancy) 23 examples altogether, account for 9.31%; Produce effects (a+b level sperm 〉=50% or a level sperm 〉=25%, but the wife's side is not conceived) 73 examples, account for 29.55%; Effectively (motility of sperm increases, but does not reach normal yet) 117 examples account for 47.37%; Invalid (motility of sperm does not change) 34 examples account for 13.77%; Total effective rate is 86.23%.After 2 course of therapy, cure 64 examples altogether, account for 25.91%; Produce effects 112 examples account for 45.34%; Effective 60 examples account for 24.29%; Invalid 11 examples account for 4.45%; Total effective rate is 95.55%.
Simultaneously, the inventor analyzes therapeutic effect and age, therapeutic effect and the relation between the course of treatment, and analysis result sees Table 1 respectively, table 2.
Table 1: vigor spermatogenesis preparation for treating effect provided by the invention and age relation table
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is 0.050〉P〉0.025, can prove that thus taking vigor spermatogenesis preparation provided by the invention treats the kidney yang deficiency syndrome azoospermia, and the therapeutic effect of each age group is not changed with the age.
Table 2: vigor spermatogenesis preparation for treating effect provided by the invention and the course of treatment relation table
With the data x in the above-mentioned table 2
2Method of inspection calculates, and the result is P＜0.005, can prove that thus taking vigor spermatogenesis preparation provided by the invention treats the kidney yang deficiency syndrome azoospermia, and along with going deep into of treatment, cure rate, obvious effective rate, effective percentage all obviously improve.
Claims (2)
1. vigor spermatogenesis preparation that is used for the treatment of azoospermia is characterized in that: the described vigor spermatogenesis preparation that is used for the treatment of azoospermia is that the following medicine material of weight ratio is made by consumption:
Air Bladder pseudosciaenae seu Acipenser 90-150 Radix Rehmanniae Preparata 70-95 Cortex Cinnamomi 25-35
Ramulus Cinnamomi 3-8 Fructus Lycii 60-120 Fructus Corni 40-80
Rhizoma Dioscoreae 70-140 Fructus Amomi 20-50 Semen Cuscutae 40-80
Radix Astragali 70-110 Radix Angelicae Sinensis 20-45 Fructus Broussonetiae 40-90
Radix Morindae Officinalis (processed) 50-70 Cortex Moutan 30-40 Herba Hedyotidis Diffusae 100-140
Radix Achyranthis Bidentatae 20-35.
2. preparation method that is used for the treatment of the vigor spermatogenesis preparation of azoospermia as claimed in claim 1, it is characterized in that: the described preparation method that is used for the treatment of the vigor spermatogenesis preparation of azoospermia is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then Rhizoma Dioscoreae, Ramulus Cinnamomi, Fructus Amomi, each 1/3rd amount of Cortex Moutan are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Rhizoma Dioscoreae, Ramulus Cinnamomi, Fructus Amomi, 12 kinds of medicine materials of Cortex Moutan and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101519123A CN101376010B (en) | 2008-09-27 | 2008-09-27 | Vigor formulation for producing sperm for treating asthenospermia and preparation method thereof |
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| CN2008101519123A CN101376010B (en) | 2008-09-27 | 2008-09-27 | Vigor formulation for producing sperm for treating asthenospermia and preparation method thereof |
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| CN101376010A CN101376010A (en) | 2009-03-04 |
| CN101376010B true CN101376010B (en) | 2010-11-10 |
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| CN2008101519123A Expired - Fee Related CN101376010B (en) | 2008-09-27 | 2008-09-27 | Vigor formulation for producing sperm for treating asthenospermia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101732534B (en) * | 2010-01-12 | 2011-12-07 | 郭太伟 | Traditional Chinese medicine for tonifying kidney, producing sperm, supplementing qi and nourishing blood |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772192A (en) * | 2004-11-08 | 2006-05-17 | 靳国春 | Medicine for treating oligospermatism |
| CN1824035A (en) * | 2006-01-12 | 2006-08-30 | 北京阜康仁生物制药科技有限公司 | Swim bladder kidney nourishing preparation and its preparation method |
| CN101066333A (en) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | Chinese medicine prepn for treating sterility of asthenospermia |
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2008
- 2008-09-27 CN CN2008101519123A patent/CN101376010B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772192A (en) * | 2004-11-08 | 2006-05-17 | 靳国春 | Medicine for treating oligospermatism |
| CN1824035A (en) * | 2006-01-12 | 2006-08-30 | 北京阜康仁生物制药科技有限公司 | Swim bladder kidney nourishing preparation and its preparation method |
| CN101066333A (en) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | Chinese medicine prepn for treating sterility of asthenospermia |
Non-Patent Citations (3)
| Title |
|---|
| 周宝宽.抗疲劳防治亚健康中药整理与研究.《中华中医药学刊》.2008,第26卷(第1期),193-195. * |
| 曹开镛.男科疾病的治疗经验.《世界中医药》.2007,第2卷(第4期),224-225. * |
| 曹彦.中医治疗少精子症近况.《广西中医药》.2003,第26卷(第3期),8-11. * |
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Effective date of registration: 20170607 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
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