CN101376012B - Formulation for treating abnormal sperm symptom, eliminating abnormal sperm and producing sperm, as well as preparation method thereof - Google Patents
Formulation for treating abnormal sperm symptom, eliminating abnormal sperm and producing sperm, as well as preparation method thereof Download PDFInfo
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- CN101376012B CN101376012B CN2008101519157A CN200810151915A CN101376012B CN 101376012 B CN101376012 B CN 101376012B CN 2008101519157 A CN2008101519157 A CN 2008101519157A CN 200810151915 A CN200810151915 A CN 200810151915A CN 101376012 B CN101376012 B CN 101376012B
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Abstract
The invention relates to a preparation with effects of eliminating abnormal sperms and promoting sperm generation for treating teratozoospermia, and a preparation method thereof. The preparation is prepared from the following materials (by weight part): Anemarrhena asphodeloides 80-100, Trionyx sinensis shell (processed) 50-70, air bladder of Pseudosciaena crocea and/or Pseudosciaena polyactis 60-70, Cortex Phellodendri 70-90, Rhizoma Polygonati 70-100, Cornus officinalis 50-70, Astragalus membranaceus 30-40, Cistanche deserticola 100-150, Fructus Amomi 30-40, Herba Taraxaci 120-180, Salvia miltiorrhiza 40-70, Angelica sinensis 40-70, and Achyranthes bidentata 20-40. The effective ingredients of the raw materials in the preparation are extracted by decoction, and activities thereof are remained, so as to remarkably improve the dissolution rate, promote absorption of the effective ingredients, and improve bioavailability. In addition, the preparation is a pure Chinese medicinal preparation, thereby resulting in good safety and no toxic or side effects after long-term administration.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relate to a kind of with Chinese medicine be raw material make be used for the treatment of teratozoospermia remove abnormal spermatogenesis preparation and preparation method thereof.
Background technology
The sperm proportion that the WHO regulation has normal morphology is called teratozoospermia less than 30%, is the unusual a kind of disease of sperm quality.The types of drugs that is used for the treatment of at present teratozoospermia clinically very little, and specific aim is not strong, and the toxic and side effects of some medicine is big, so take back DeGrain for treatment belongs to this disease of teratozoospermia.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of treatment teratozoospermia effect obvious, thereby with strong points, and the abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia that has no side effect.
Another object of the present invention is to provide a kind of above-mentioned method of removing abnormal spermatogenesis preparation that is used to prepare.
In order to achieve the above object, the abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
The Rhizoma Anemarrhenae 80-100 Carapax Trionycis (system) 50-70 Air Bladder pseudosciaenae seu Acipensers 60-70
Cortex Phellodendri 70-90 Rhizoma Polygonatis 70-100 Fructus Corni 50-70
The Radix Astragali 30-40 Herba Cistanches 100-150 Fructus Amomis 30-40
Herba Taraxaci 120-180 Radix Salviae Miltiorrhizaes 40-70 Radix Angelicae Sinensis 40-70
Radix Achyranthis Bidentatae 20-40
The described preparation method of removing abnormal spermatogenesis preparation that is used for the treatment of teratozoospermia is according to the following step
Rapid order is carried out:
(a) the said medicine raw material is carried out weighing according to proportioning, then the Rhizoma Anemarrhenae, Fructus Amomi, each 1/3rd amount of Radix Salviae Miltiorrhizae are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) the remaining Rhizoma Anemarrhenae, Fructus Amomi, 10 kinds of medicine materials of Radix Salviae Miltiorrhizae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
The abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia provided by the invention is that the method that adopts decocting in water to extract is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
The semen efamination sperm morphology surpasses more than 40% unusually, is teratospermia, and this is one of major reason that causes masculine sterility.The traditional Chinese medical science thinks that this disease is many because of congenital defect, intemperate sexual intercourse, and indulge in carnal pleasure without restraint, or masturbation is frequent, damage of kidney-YIN, hyperactivity of fire caused by deficiency of YIN, the sperm of burning; Also there is venation not smooth, blood-stasis internal-depression, damage sperm, and the teratogenesis shape person of increasing.So therapy is worked as nourishing YIN to lower pathogenic fire, kidney tonifying, essence replenishing, it is logical smart to invigorate blood circulation.Air Bladder pseudosciaenae seu Acipenser is salty in the side is slightly cold, big replenishing vital essence and blood; Carapax Trionycis is salty flat, nourishing YIN for suppressing the hyperactive YANG, and disease eliminating powder junction, two medicines are the in love product of flesh and blood, so the power of YIN nourishing is strong.The Rhizoma Anemarrhenae is bitter sweet cold, nourishing YIN and clearing away heat; The Cortex Phellodendri bitter cold, clearing away damp-heat, the pathogenic fire purging poison, two medicines share, but both losses of nourishing kidney yin can be rushed down the asthenic fire of kidney again.More than four product nourishing YIN to lower pathogenic fire be monarch drug altogether.The sweet temperature of urosolic acid, nourishing the liver and kidney, reinforcing the kindey to control nocturnal emission; Rhizoma Polygonati is sweet flat, and QI invigorating increases liquid; The sweet temperature of Herba Cistanches, kidney-replenishing, kidney tonifying essence; The sweet tepor of the Radix Astragali, tonifying Qi and lifting yang; The sweet temperature of Radix Angelicae Sinensis is enriched blood and is invigorated blood circulation.But above medicine kidney and spleen invigorating makes sperm biochemistry active, is ministerial drug altogether.The Radix Salviae Miltiorrhizae hardship is slightly cold, nourshing blood and promoting blood circulation, disease eliminating powder junction; The hot temperature of Fructus Amomi, the kidney tonifying of being amusing, and the taste of system tonic is greasy; The Herba Taraxaci bitter cold, heat-clearing and toxic substances removing is held concurrently with dampness removing, and medicine-feeding is adjuvant drug altogether.The Radix Achyranthis Bidentatae suffering is slightly cold, blood circulation promoting and blood stasis dispelling, and priming is descending, thinks messenger drug.
Below in conjunction with embodiment abnormal spermatogenesis preparation and preparation method thereof that removes that is used for the treatment of teratozoospermia provided by the invention is elaborated.
Embodiment 1:
The abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
The Rhizoma Anemarrhenae 90 Carapax Trionycis (system) 60 Air Bladder pseudosciaenae seu Acipensers 60
Cortex Phellodendri 90 Rhizoma Polygonatis 90 Fructus Corni 60
The Radix Astragali 30 Herba Cistanches 120 Fructus Amomis 34
Herba Taraxaci 150 Radix Salviae Miltiorrhizaes 57 Radix Angelicae Sinensis 60
Radix Achyranthis Bidentatae 30
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, then the Rhizoma Anemarrhenae, Fructus Amomi, each 1/3rd amount of Radix Salviae Miltiorrhizae are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) the remaining Rhizoma Anemarrhenae, Fructus Amomi, 10 kinds of medicine materials of Radix Salviae Miltiorrhizae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
The abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
The Rhizoma Anemarrhenae 80 Carapax Trionycis (system) 50 Air Bladder pseudosciaenae seu Acipensers 60
Cortex Phellodendri 70 Rhizoma Polygonatis 70 Fructus Corni 50
The Radix Astragali 30 Herba Cistanches 100 Fructus Amomis 30
Herba Taraxaci 120 Radix Salviae Miltiorrhizaes 40 Radix Angelicae Sinensis 40
Radix Achyranthis Bidentatae 20
Preparation method is with embodiment 1.
Embodiment 3:
The abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
The Rhizoma Anemarrhenae 100 Carapax Trionycis (system) 70 Air Bladder pseudosciaenae seu Acipensers 70
Cortex Phellodendri 90 Rhizoma Polygonatis 100 Fructus Corni 70
The Radix Astragali 40 Herba Cistanches 150 Fructus Amomis 40
Herba Taraxaci 180 Radix Salviae Miltiorrhizaes 70 Radix Angelicae Sinensis 70
Radix Achyranthis Bidentatae 40
Preparation method is with embodiment 1.
The abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia provided by the invention is brown to sepia; Feeble QI, it is little salty to distinguish the flavor of.In order to verify that this removes the therapeutic effect of abnormal spermatogenesis preparation, the inventor utilizes the above-mentioned patient who 294 examples is suffered from the type of hyperactivity of fire caused by deficiency of YIN teratozoospermia except that the capsule that belongs to oral solid formulation in the abnormal spermatogenesis preparation to carry out system's clinical observation, 21-30 years old patient's 102 examples wherein, 31-40 years old patient's 153 examples, 41-50 years old patient's 39 examples, 3 of each medications, every day 2 times, 70 days is 1 course of treatment.After 1 course of therapy, cure (sperm concentration is normal, teratospermia＜30%, and wife's side pregnancy) 34 examples altogether, account for 11.6%; Produce effects (sperm concentration is normal, teratospermia＜30%, but the wife's side is not conceived) 111 examples, account for 37.8%; Effectively (sperm concentration increases, and the teratospermia ratio descends to some extent, but does not reach normal yet) 129 examples account for 43.9%; Invalid (the teratospermia ratio does not change) 20 examples account for 6.8%; Total effective rate is 93.2%.After 2 course of therapy, cure 85 examples altogether, account for 90.4%; Produce effects 128 examples account for 43.5%; Effective 167 examples account for 56.8%; Invalid 14 examples account for 4.8%; Total effective rate is 95.2%.
Simultaneously, the inventor analyzes therapeutic effect and age, therapeutic effect and the relation between the course of treatment, and analysis result sees Table 1 respectively, table 2.
Table 1: abnormal spermatogenesis preparation for treating effect and the age relation table of removing provided by the invention
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is 0.050〉P〉0.025, can prove thus to take provided by the inventionly to remove abnormal spermatogenesis preparation and treat the type of hyperactivity of fire caused by deficiency of YIN teratozoospermia, and the therapeutic effect of each age group is not changed with the age.
Table 2: provided by the invention remove abnormal spermatogenesis preparation for treating effect and the course of treatment relation table
With the data x in the above-mentioned table 2
2Method of inspection calculates, and the result is P＜0.005, can prove thus to take provided by the inventionly to remove abnormal spermatogenesis preparation and treat the type of hyperactivity of fire caused by deficiency of YIN teratozoospermia, and along with going deep into of treatment, cure rate, obvious effective rate, effective percentage all obviously improve.
Claims (2)
1. abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia is characterized in that: the described abnormal spermatogenesis preparation that removes that is used for the treatment of teratozoospermia is that the following medicine material of weight ratio is made by consumption:
Rhizoma Anemarrhenae 80-100 Carapax Trionycis (processed) 50-70 Air Bladder pseudosciaenae seu Acipenser 60-70
Cortex Phellodendri 70-90 Rhizoma Polygonati 70-100 Fructus Corni 50-70
Radix Astragali 30-40 Herba Cistanches 100-150 Fructus Amomi 30-40
Herba Taraxaci 120-180 Radix Salviae Miltiorrhizae 40-70 Radix Angelicae Sinensis 40-70
Radix Achyranthis Bidentatae 20-40.
2. preparation method of removing abnormal spermatogenesis preparation that is used for the treatment of teratozoospermia as claimed in claim 1, it is characterized in that: the described preparation method of removing abnormal spermatogenesis preparation that is used for the treatment of teratozoospermia is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then the Rhizoma Anemarrhenae, Fructus Amomi, each 1/3rd amount of Radix Salviae Miltiorrhizae are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) the remaining Rhizoma Anemarrhenae, Fructus Amomi, 10 kinds of medicine materials of Radix Salviae Miltiorrhizae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519157A CN101376012B (en) | 2008-09-27 | 2008-09-27 | Formulation for treating abnormal sperm symptom, eliminating abnormal sperm and producing sperm, as well as preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519157A CN101376012B (en) | 2008-09-27 | 2008-09-27 | Formulation for treating abnormal sperm symptom, eliminating abnormal sperm and producing sperm, as well as preparation method thereof |
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| CN101376012A CN101376012A (en) | 2009-03-04 |
| CN101376012B true CN101376012B (en) | 2011-02-02 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416835A (en) * | 2001-11-08 | 2003-05-14 | 钟凯 | Chinese medicine prepn for treating male's sexual dysfunction systematically |
| CN101049422A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Composition of Chinese traditional medicine for treating barrenness caused by dead sperm |
| CN101066366A (en) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | Chinese medicine prepn for treating sterility of prospermia |
| CN101195015A (en) * | 2007-11-30 | 2008-06-11 | 黄宁芝 | Chinese medicine for treating barrenness |
-
2008
- 2008-09-27 CN CN2008101519157A patent/CN101376012B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416835A (en) * | 2001-11-08 | 2003-05-14 | 钟凯 | Chinese medicine prepn for treating male's sexual dysfunction systematically |
| CN101049422A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Composition of Chinese traditional medicine for treating barrenness caused by dead sperm |
| CN101066366A (en) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | Chinese medicine prepn for treating sterility of prospermia |
| CN101195015A (en) * | 2007-11-30 | 2008-06-11 | 黄宁芝 | Chinese medicine for treating barrenness |
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| CN101376012A (en) | 2009-03-04 |
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Effective date of registration: 20170627 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
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