CN101376015B - Sperm-stopping formulation for treating spermatorrhea and preparation method thereof - Google Patents
Sperm-stopping formulation for treating spermatorrhea and preparation method thereof Download PDFInfo
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- CN101376015B CN101376015B CN2008101519388A CN200810151938A CN101376015B CN 101376015 B CN101376015 B CN 101376015B CN 2008101519388 A CN2008101519388 A CN 2008101519388A CN 200810151938 A CN200810151938 A CN 200810151938A CN 101376015 B CN101376015 B CN 101376015B
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Abstract
The invention relates to a preparation with effect of arresting spontaneous emission for treating spermatorrhea, and a preparation method thereof. The preparation is prepared from the following materials (by weight part): Schisandra chinensis fruit 40-180, Rosa laevigata fruit 80-240, Euryale ferox seed (parched) 75-210, Coix lacryma-jobi seed (parched) 60-165, Cynomorium songaricum (processed) 30-80, Concha Ostreae 100-190, Os Draconis 115-170, Poria cocos 10-30, Semen Armeniacae Amarum (rolled) 10-24, Magnolia officinalis (processed) 20-50, Pinellia ternate (purified) 15-45, Radix Bupleuri 18-45, Scutellaria baicalensis 25-55, Fructus Amomi Rotundus 80-150, Lophatherum gracile 35-85, and talc powder 50-120. The effective ingredients of the raw materials in the preparation are extracted by decoction, and activities thereof are remained, so as to remarkably improve the dissolution rate, promote absorption of the effective ingredients, and improve bioavailability. In addition, the preparation is a pure Chinese medicinal preparation, thereby resulting in good safety and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relating to a kind of is only finishing agent and preparation method thereof that is used for the treatment of seminal emission that raw material is made with Chinese medicine.
Background technology
Medically the general is not called seminal emission because of the disease of sexual life seminal fluid spermatorrhea.Dream is wherein arranged and seminal emission person, by name " nocturnal emission ", no dream and seminal emission person, even seminal fluid outflow person when clear-headed are called " spermatorrhea ".Though it is many to be used for the treatment of the types of drugs of seminal emission at present clinically, specific aim is not strong, and the toxic and side effects of some medicine is big, so take back DeGrain for this disease of treatment seminal emission.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of treatment stagnation of liver-QI renal deficiency type seminal emission effect obvious, thereby with strong points, and the finishing agent that ends that is used for the treatment of seminal emission that has no side effect.
Another object of the present invention is to provide a kind of above-mentioned method of ending finishing agent that is used to prepare.
In order to achieve the above object, the finishing agent that ends that is used for the treatment of seminal emission provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Schisandrae Chinensis 40-180 Fructus Rosae Laevigatae, 80-240 Semen Euryaless (stir-fry) 75-210
Semen Coicis (stir-fry) 60-165 Herba Cynomoriis (system) 30-80 Concha Ostreaes 100-190
Os Draconis 115-170 Poria, 10-30 Semen Armeniacae Amarums (rolling) 10-24
Cortex Magnoliae Officinalis (system) 20-50 Rhizoma Pinelliaes (clearly) 15-45 Radix Bupleuri 18-45
Radix Scutellariae 25-55 Fructus Amomi Rotunduss 80-150 Herba Lophatheris 35-85
Pulvis Talci 50-120
The described preparation method of ending finishing agent that is used for the treatment of seminal emission is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then Semen Coicis, Semen Armeniacae Amarum, Radix Bupleuri, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Poria, each 1/3rd amount of Pulvis Talci are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Semen Coicis, Semen Armeniacae Amarum, Radix Bupleuri, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Poria, 9 kinds of medicine materials of Pulvis Talci and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
The method that the only finishing agent that is used for the treatment of seminal emission provided by the invention is the extraction of employing decocting in water is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
This side is set for the treatment seminal emission.The sweet temperature of trimethyl gallic acid in the side, the nourishing kidney arresting seminal emission; Fructus Rosae Laevigatae acid is flat, the secret gas of controlling nocturnal emission with astringent drugs; Semen Euryales is sweet puckery flat, the spleen invigorating of reinforcing the kidney.Three medicine mutual reinforcements between are usefulness, and the controlling nocturnal emission with astringent drugs kidney tonifying is thought monarch drug.The sweet temperature of Herba Cynomorii, kidney-replenishing, benefiting essence-blood; Os Draconis are sweet puckery cold, restrain astringent or styptic treatment for spontaneous sweating, tranquillizing and allaying excitement; Concha Ostreae is salty to be slightly cold, arresting sweating arresting seminal emission, suppressing the hyperactive liver and subsiding YANG; Poria is sweet light flat, invigorating spleen to remove dampness; Sweet light being slightly cold of Semen Coicis, the spleen invigorating eliminating dampness by diuresis; Medicine-feeding kidney and spleen invigorating, controlling nocturnal emission with astringent drugs end to be lost, and with the power of principal drug assistance, is to be ministerial drug.The Radix Bupleuri suffering is slightly cold, but both soothing liver-QI for relieving depression, but ascending up spleen-Qi and Yang again; The hot temperature of the Rhizoma Pinelliae, drying dampness to eliminate phlegm, dissolving lump and resolving mass; Cortex Magnoliae Officinalis toil temperature, promoting the circulation of QI to remove dampness; The hot temperature of Fructus Amomi Rotundus, the removing dampness circulation of qi promoting, the Semen Armeniacae Amarum tepor, relieving cough and asthma has the power of the therapeutic method to keep the adverse QI flowing downwards, the Radix Scutellariae bitter cold, heat clearing and damp drying, more than all medicines share, but the soothing liver-QI circulation of qi promoting, invigorating the spleen for eliminating dampness is adjuvant drug.Talcum is sweet light cold, and clearing away heat and promoting diuresis is treating stranguria; Herba Lophatheri is sweet light cold, and clearing away heat-damp and promoting diuresis, two medicines can make damp and hot heresy go out from urine, are messenger drug.Full side is with the controlling nocturnal emission with astringent drugs kidney tonifying, and soothing liver and strengthening spleen is an aim, is consolidated in order to do kidney, and spleen is good for, and stagnation of liver-QI is separated, and damp is dispelled, and then the spermatorrhea of essence is from working as recovery from illness.
Below in conjunction with embodiment finishing agent and preparation method thereof that ends that is used for the treatment of seminal emission provided by the invention is elaborated.
Embodiment 1:
The finishing agent that ends that is used for the treatment of seminal emission in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Schisandrae Chinensis 120 Fructus Rosae Laevigatae, 150 Semen Euryaless (stir-fry) 150
Semen Coicis (stir-fry) 120 Herba Cynomoriis (system) 60 Concha Ostreaes 150
Os Draconis 150 Poria, 15 Semen Armeniacae Amarums (rolling) 15
Cortex Magnoliae Officinalis (system) 30 Rhizoma Pinelliaes (clearly) 30 Radix Bupleuri 30
Radix Scutellariae 30 Fructus Amomi Rotunduss 120 Herba Lophatheris 60
Pulvis Talci 90
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, then Semen Coicis, Semen Armeniacae Amarum, Radix Bupleuri, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Poria, each 1/3rd amount of Pulvis Talci are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Semen Coicis, Semen Armeniacae Amarum, Radix Bupleuri, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Poria, 9 kinds of medicine materials of Pulvis Talci and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
The finishing agent that ends that is used for the treatment of seminal emission in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Schisandrae Chinensis 40 Fructus Rosae Laevigatae, 80 Semen Euryaless (stir-fry) 75
Semen Coicis (stir-fry) 60 Herba Cynomoriis (system) 30 Concha Ostreaes 100
Os Draconis 115 Poria, 10 Semen Armeniacae Amarums (rolling) 10
Cortex Magnoliae Officinalis (system) 20 Rhizoma Pinelliaes (clearly) 15 Radix Bupleuri 18
Radix Scutellariae 25 Fructus Amomi Rotunduss 80 Herba Lophatheris 35
Pulvis Talci 50
Preparation method is with embodiment 1.
Embodiment 3:
The finishing agent that ends that is used for the treatment of seminal emission in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Fructus Schisandrae Chinensis 180 Fructus Rosae Laevigatae, 240 Semen Euryaless (stir-fry) 210
Semen Coicis (stir-fry) 165 Herba Cynomoriis (system) 80 Concha Ostreaes 190
Os Draconis 170 Poria, 30 Semen Armeniacae Amarums (rolling) 24
Cortex Magnoliae Officinalis (system) 50 Rhizoma Pinelliaes (clearly) 45 Radix Bupleuri 45
Radix Scutellariae 55 Fructus Amomi Rotunduss 150 Herba Lophatheris 85
Pulvis Talci 120
Preparation method is with embodiment 1.
The finishing agent that ends that is used for the treatment of seminal emission provided by the invention is brown to sepia; Gas is light, and it is little puckery to distinguish the flavor of.In order to verify that this ends the therapeutic effect of finishing agent, the inventor utilizes and above-mentionedly ends the patient that the capsule that belongs to oral solid formulation in the finishing agent suffers from seminal emission to 297 examples and carried out system's clinical observation, 21-30 year patient's 97 examples wherein, 31-40 year 102 examples, 41-50 year 98 examples, 3 of each medications, every day 2 times, 60 days is 1 course of treatment.After 1 course of therapy, cure (the seminal emission phenomenon recovers normal, and other symptom also disappears substantially) 23 examples altogether, account for 7.8%; Effectively (the seminal emission phenomenon changes to some extent, and other symptom has significant change) 187 examples account for 63.0%; Invalid (the seminal emission phenomenon does not change, and other symptom does not have significant change) 87 examples account for 29.2%; Total effective rate is 70.8%.After 2 course of therapy, cure 65 examples altogether, account for 21.9%; Effective 188 examples account for 63.3%; Invalid 44 examples account for 14.8%; Total effective rate is 85.2%.
Simultaneously, the inventor analyzes therapeutic effect and age, therapeutic effect and the relation between the course of treatment, and analysis result sees Table 1 respectively, table 2.
Table 1: finishing agent therapeutic effect and the age relation table of ending provided by the invention
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is 0.050〉P〉0.025, can prove that thus taking the finishing agent that ends provided by the invention treats seminal emission, and the therapeutic effect of each age group is not changed with the age.
Table 2: provided by the invention end the finishing agent therapeutic effect and the course of treatment relation table
With the data x in the above-mentioned table 2
2Method of inspection calculates, and the result is P＜0.005, can prove that thus taking the finishing agent that ends provided by the invention treats seminal emission, and along with going deep into of treatment, cure rate, effective percentage all obviously improve.
Claims (2)
1. finishing agent that ends that is used for the treatment of seminal emission is characterized in that: the described finishing agent that ends that is used for the treatment of seminal emission is that the following medicine material of weight ratio is made by consumption:
Fructus Schisandrae Chinensis 40-180 Fructus Rosae Laevigatae 80-240 Semen Euryales (parched) 75-210
Semen Coicis (parched) 60-165 lockmaking sun 30-80 Concha Ostreae 100-190
Os Draconis 115-170 Poria 10-30 Semen Armeniacae Amarum (rolled) 10-24
Sichuan Cortex Magnoliae Officinalis (processed) 20-50 Rhizoma Pinelliae 15-45 Radix Bupleuri 18-45
Radix Scutellariae 25-55 Fructus Amomi Rotundus 80-150 Herba Lophatheri 35-85
Pulvis Talci 50-120.
2. preparation method of ending finishing agent that is used for the treatment of seminal emission as claimed in claim 1, it is characterized in that: the described preparation method of ending finishing agent that is used for the treatment of seminal emission is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then Semen Coicis (parched), Semen Armeniacae Amarum (rolled), Radix Bupleuri, Sichuan Cortex Magnoliae Officinalis (processed), Rhizoma Pinelliae, Poria, each 1/3rd amount of Pulvis Talci are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Semen Coicis (parched), Semen Armeniacae Amarum (rolled), Radix Bupleuri, Sichuan Cortex Magnoliae Officinalis (processed), Rhizoma Pinelliae, Poria, 9 kinds of medicine materials of Pulvis Talci and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519388A CN101376015B (en) | 2008-09-27 | 2008-09-27 | Sperm-stopping formulation for treating spermatorrhea and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519388A CN101376015B (en) | 2008-09-27 | 2008-09-27 | Sperm-stopping formulation for treating spermatorrhea and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101376015A CN101376015A (en) | 2009-03-04 |
| CN101376015B true CN101376015B (en) | 2010-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101519388A Expired - Fee Related CN101376015B (en) | 2008-09-27 | 2008-09-27 | Sperm-stopping formulation for treating spermatorrhea and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297742A (en) * | 2000-03-28 | 2001-06-06 | 刘珀 | Chinese medicine tincture and its preparation |
| CN1765402A (en) * | 2005-09-29 | 2006-05-03 | 李亚萍 | Chinese herbal decoction for treating apontaneous emission of premier fire abnormal active pattern and preparation method |
| CN101239144A (en) * | 2007-02-10 | 2008-08-13 | 杨绪民 | 'Qiziyangzhendan' special for treating deficiency-cold of below yuan, instability of ejaculation guan, unconscious sperm-emission, urorrhea, metrorrhagia and leukorrhea |
-
2008
- 2008-09-27 CN CN2008101519388A patent/CN101376015B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297742A (en) * | 2000-03-28 | 2001-06-06 | 刘珀 | Chinese medicine tincture and its preparation |
| CN1765402A (en) * | 2005-09-29 | 2006-05-03 | 李亚萍 | Chinese herbal decoction for treating apontaneous emission of premier fire abnormal active pattern and preparation method |
| CN101239144A (en) * | 2007-02-10 | 2008-08-13 | 杨绪民 | 'Qiziyangzhendan' special for treating deficiency-cold of below yuan, instability of ejaculation guan, unconscious sperm-emission, urorrhea, metrorrhagia and leukorrhea |
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| Publication number | Publication date |
|---|---|
| CN101376015A (en) | 2009-03-04 |
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Effective date of registration: 20170606 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
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Granted publication date: 20101110 Termination date: 20210927 |
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