CN1175461A - Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof - Google Patents
Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof Download PDFInfo
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- CN1175461A CN1175461A CN 97118754 CN97118754A CN1175461A CN 1175461 A CN1175461 A CN 1175461A CN 97118754 CN97118754 CN 97118754 CN 97118754 A CN97118754 A CN 97118754A CN 1175461 A CN1175461 A CN 1175461A
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- notoginseng
- herba capsellae
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Abstract
A medicinal composition in the form of capsule for preventing and curing cardiovascular and cerebrovascular diseases including cerebral thrombosis, hemiplegia, hypertension and coronary heart disease is prepared from 10 Chinese-medicinal materials suhc as red sage root, astragalus root, pseudostellaria root, notoginseng, eucommia bark, etc through preparing extract, decocting part of raw materials, concentration, drying, pulverizing, mixing and filling in capsules. Its advantages are convenient application, quickly taking its effect, durable power and no toxicity.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease, particularly relating to a kind of is the medicine of the treatment cardiovascular and cerebrovascular disease made of raw material with the vegetable Chinese herbal medicine.
Cardiovascular and cerebrovascular disease is the No.1 killer of harm humans health, China die from every year this disease reach 200 surplus ten thousand people.In recent years, domestic medical worker makes great efforts to excavate motherland's pools of traditional Chinese medicine, has developed in succession as ZHONGFENG HUICHUN WAN, XINKESHU PIAN, XINNAOSHUTONG JIAONANG (sheet), magnificent precious open capsule, Chinese patent medicines such as LEMAI KELI make the treatment of cardiovascular and cerebrovascular disease and prevention that new development arranged.These medicines of being developed are laid particular stress on blood circulation promoting and blood stasis dispelling, and are negligent of antiinflammatory, diuretic antihypertensive mostly with prescriptions such as the Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthamis, and onset is slow, and curative effect is not good enough.CN1123690A discloses a kind of Naoxuekang capsule for curing cerebrovascular disease, is used for the treatment of alzheimer disease, but prescription is complicated, and therapeutic domain is narrow partially.
Purpose of the present invention is to provide a kind of easy to use, rapid-action, the Chinese patent medicine of eutherapeutic treatment cardiovascular and cerebrovascular disease.
Principle of the present invention is as follows.Application Radix Salviae Miltiorrhizae, Radix Astragali blood circulation promoting and blood stasis dispelling are monarch drug; The Radix Pseudostellariae replenishing QI to invigorate the spleen, the Radix Polygalae fallacis vigorate qi and replenish the blood, the blood pressure lowering of Herba Capsellae diuretic, hemostasis, heat-clearing and toxic substances removing, three medicines are combined into ministerial drug; Radix Notoginseng dissipating phlegm and hemastasis, removing obstruction in the collateral to relieve pain, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, inducing diuresis to remove edema, Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, Radix Rehmanniae Preparata nourishing YIN and supplementing blood, four medicines are adjuvant drug altogether; Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription are messenger drug.All medicines are collaborative, the effect of yielding result altogether, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, promoting the circulation of QI to relieve pain, clearing away heat and relieving the wind syndrome.
Each crude drug shared percentage by weight in prescription is:
Radix Salviae Miltiorrhizae 9~19% Radixs Astragali 9~19% Radix Pseudostellariaes 6~17% Radix Polygalae fallaciss 6~17% Herba Capsellaes 6~17% Radix Notoginseng 1~5% Radix Glycyrrhizae 1~5% Herba Hedyotidis Diffusae 6~17% Cortexs Eucommiae 6~17% Radix Rehmanniaes Preparata 6~17%
Clinical treatment actual measurement curative effect and matched group comparable situation are as follows:
Group | Total routine number | Medicine and dosage | The course of treatment (my god) | Curative effect | ||||
Be almost recovered | Produce effects | Effectively | Invalid | Total effective rate | ||||
The treatment group | ?70 | 4/time of capsules of the present invention | ???30 | ??8(11.4%) | ???54(77.2%) | ??7(109%) | ???1(1.4%) | ??98.6% |
Matched group | ?32 | LEMAI KELI 2 bags/time | ???30 | ??0(06) | ???12(37.5%) | ??12(37.5%) | ???8(25%) | ??75% |
The P value | ??<0.05 | ????<0.01 | ????<0.05 | ????<0.05 | ??<0.05 |
Pharmaceutical composition of the present invention is made treatment cardiovascular and cerebrovascular disease Chinese patent medicine with the medical herbs prescription of Chinese medicine and less use, has easy to usely, and clinical onset of action is fast, lasting medicine, the characteristics of safety non-toxic are effective equally to stroke in convalescent stage and stiff phase.Capsule adopts dry extract to granulate, and its drug loading is big, and dissolubility is good, and the bioavailability height is taken and storage, convenient transportation, is applicable to the treatment and the prevention of cardiovascular and cerebrovascular diseases such as cerebral thrombosis, hemiplegia, hypertension, coronary heart disease.
The embodiment of the invention is as follows:
(1) take by weighing Radix Salviae Miltiorrhizae 15Kg, Radix Pseudostellariae 10Kg places extraction pot, adds 75% ethanol, extracts each 1.5-2 hour at twice.Merge extractive liquid,, heating concentrates, and makes extractum;
(2) take by weighing Radix Notoginseng 3Kg, Herba Capsellae 3Kg crosses 80 mesh sieves behind the pulverize separately, make Herba Capsellae powder and Radix Notoginseng powder;
(3) with the Radix Salviae Miltiorrhizae behind ethanol extraction, Radix Pseudostellariae medicinal residues, Herba Capsellae 7Kg, Radix Astragali 12Kg, Radix Polygalae fallacis 10Kg, Radix Rehmanniae Preparata, the Cortex Eucommiae, each 8Kg of Herba Hedyotidis Diffusae, Radix Glycyrrhizae 3Kg adds the decocting that 8-10 doubly measures and boils twice, and 2 hours for the first time, 1.5 hours for the second time.Merge decocting liquid, heating is concentrated into thick paste;
(4) respectively with prepared extractum and the dry powder process of thick paste, mix thoroughly with prepared Herba Capsellae powder and Radix Notoginseng powder, the preparation legal system is equipped with capsule routinely again.
Can make capsule 0.3g * 10000 according to above-mentioned prescription dosage and method.
Claims (3)
1, a kind of treatment cardiovascular and cerebrovascular diseases medicament compositions, it is characterized in that: form by salviamiltiorrhizabung, the Radix Astragali, Radix Pseudostellariae, Radix Notoginseng, the Cortex Eucommiae, Radix Rehmanniae Preparata, Radix Glycyrrhizae and medical herbs Radix Polygalae fallacis, Herba Capsellae, Herba Hedyotidis Diffusae prescription, each crude drug shared percentage by weight in prescription is: Radix Salviae Miltiorrhizae, the Radix Astragali are respectively 9-19%, Radix Pseudostellariae, Radix Polygalae fallacis, Herba Capsellae, Herba Hedyotidis Diffusae, the Cortex Eucommiae, Radix Rehmanniae Preparata are respectively 6-17%, and Radix Notoginseng, Radix Glycyrrhizae are respectively 1-5%.
2, a kind of preparation treatment cardiovascular and cerebrovascular diseases medicament method for compositions, it is characterized in that: Radix Salviae Miltiorrhizae, Radix Pseudostellariae make extractum with 75% ethanol extraction; Get the Herba Capsellae of Radix Notoginseng and 1/3 weight, pulverize the back and cross 80 mesh sieves, make Herba Capsellae powder and Radix Notoginseng powder respectively; With the Radix Salviae Miltiorrhizae behind ethanol extraction, Radix Pseudostellariae medicinal residues, surplus 2/3 Herba Capsellae and the Radix Astragali, Radix Polygalae fallacis, Herba Hedyotidis Diffusae, the Cortex Eucommiae, Radix Rehmanniae Preparata, Radix Glycyrrhizae decoct with water twice, merge twice decoction liquor, and heating is condensed into thick paste; With prepared extractum and the dry powder process of thick paste, mix thoroughly with prepared Herba Capsellae powder and Radix Notoginseng powder respectively, the preparation legal system is equipped with capsule routinely again.
3, according to the preparation method of claim 2, it is characterized in that prepared extractum and the dry powder process of thick paste are adopted spray drying process powder process, its baking temperature is less than 80 ℃.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 97118754 CN1175461A (en) | 1997-10-01 | 1997-10-01 | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof |
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CN 97118754 CN1175461A (en) | 1997-10-01 | 1997-10-01 | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof |
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CN1175461A true CN1175461A (en) | 1998-03-11 |
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CN 97118754 Pending CN1175461A (en) | 1997-10-01 | 1997-10-01 | Medicine composition for treating cardiovascular and cerebrovascular diseases and preparing process thereof |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103251764A (en) * | 2013-05-21 | 2013-08-21 | 温业林 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
CN104398809A (en) * | 2014-11-09 | 2015-03-11 | 朱海燕 | Traditional Chinese medicine composition for treating coronary heart disease, preparation method and applications thereof |
CN105617355A (en) * | 2016-01-29 | 2016-06-01 | 徐宝贞 | Medicine for treating cardiovascular and cerebrovascular diseases |
CN107714849A (en) * | 2017-11-16 | 2018-02-23 | 广西博白县华春福家庭农场 | A kind of Chinese medicine composition for treating myocardial ischemia and preparation method thereof |
-
1997
- 1997-10-01 CN CN 97118754 patent/CN1175461A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103251764A (en) * | 2013-05-21 | 2013-08-21 | 温业林 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
CN103251764B (en) * | 2013-05-21 | 2015-08-26 | 温业林 | A kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof |
CN104398809A (en) * | 2014-11-09 | 2015-03-11 | 朱海燕 | Traditional Chinese medicine composition for treating coronary heart disease, preparation method and applications thereof |
CN105617355A (en) * | 2016-01-29 | 2016-06-01 | 徐宝贞 | Medicine for treating cardiovascular and cerebrovascular diseases |
CN107714849A (en) * | 2017-11-16 | 2018-02-23 | 广西博白县华春福家庭农场 | A kind of Chinese medicine composition for treating myocardial ischemia and preparation method thereof |
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