CN106109968A - Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition and preparation method thereof - Google Patents
Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition and preparation method thereof Download PDFInfo
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- CN106109968A CN106109968A CN201610637984.3A CN201610637984A CN106109968A CN 106109968 A CN106109968 A CN 106109968A CN 201610637984 A CN201610637984 A CN 201610637984A CN 106109968 A CN106109968 A CN 106109968A
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- polygoni multiflori
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to field of traditional Chinese medicine pharmacy, be specifically related to a kind of Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition.The Rhizoma Gastrodiae of the present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition, prepared by the raw material including following weight: Rhizoma Gastrodiae 2-8 part, Radix Angelicae Dahuricae 2-6 part, Radix Polygoni Multiflori Preparata 5-10 part, Radix Rehmanniae Preparata 5-10 part, Radix Salviae Miltiorrhizae 5-10 part, Rhizoma Chuanxiong 1-6 part, Herba Ecliptae 7-14 part, Fructus Ligustri Lucidi (system) 7-14 part, Radix Paeoniae Alba 7-14 part, Rhizoma Polygonati (system) 7-14 part, Radix Glycyrrhizae 1-5 part, Radix Angelicae Sinensis 7-14 part, Folium Mori 3-8 part, stir-baked FRUCTUS TRIBULI 3-8 part.Prior art is improved by the present invention, on the basis of tradition hospital, have employed Radix Polygoni Multiflori Preparata, Fructus Ligustri Lucidi (system), the scheme of Rhizoma Polygonati (system).Overcome tradition hospital and be easily caused user's diarrhoea and the problem of throat discomfort.
Description
Technical field
The present invention relates to field of traditional Chinese medicine pharmacy, be specifically related to a kind of Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition and preparation side thereof
Method.
Background technology
Gastrodia tuber and fleece-flower root medicine in the market is all tablet or capsule, and its preparation method is by Rhizoma Gastrodiae, Radix Polygoni Multiflori, river
Rhizome of chuanxiong is broken into fine powder, then mixes with the water extracted immersing paste of Radix Angelicae Sinensis, the Radix Angelicae Dahuricae etc., is dried, and after being broken into powder, then adds adjuvant and makes
Grain, makes capsule the most again or is pressed into sheet.The Chinese invention patent application of Publication No. CN1689605, discloses a kind of Rhizoma Gastrodiae
The preparation method of Radix Polygoni Multiflori micropill, makes gastrodia tuber and fleece-flower root medicated powder the Chinese herbal medicine such as Rhizoma Gastrodiae, Radix Polygoni Multiflori, adds medicated powder amount 1～the paste of 5 times
Essence (or starch or the adjuvant such as microcrystalline Cellulose or Icing Sugar), mixing, with Diluted Alcohol or simple syrup as wetting agent, use general ball
Method or extrude round as a ball pelletization method or centrifugal fluidization is made ball method and made 1.0～2.5mm gastrodia tuber and fleece-flower root micropills.Publication No.
The Chinese invention patent application of CN1583056 discloses a kind of gastrodia tuber and fleece-flower root preparation, and it is main component and percentage by weight thereof
For Rhizoma Gastrodiae 2-8%, Radix Angelicae Dahuricae 1-6%, the Radix Polygoni Multiflori, Radix Rehmanniae Preparata, each 4-12% of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 1-6% is Herba Ecliptae, Fructus Ligustri Lucidi, white
The each 5-15% of Chinese herbaceous peony, Rhizoma Polygonati, Radix Angelicae Sinensis, Radix Glycyrrhizae 1-5%, Folium Mori, each 2-10% of Fructus Tribuli, containing the capsule of appropriate amount of auxiliary materials.System
Preparation Method is: take the Radix Angelicae Dahuricae by weight percentage, Radix Angelicae Sinensis extracts volatile oil；Rhizoma Gastrodiae, Rhizoma Chuanxiong, radix polygoni multiflori powder are broken into fine powder；Medicinal residues and its
His medical material extracting in water, the clear paste that filtrate is condensed into, or it is dried to dry cream；By crude drug powder and clear paste or the mixing of dry cream, add suitable
Amount adjuvant is pelletized, or being not added with adjuvant pelletizes, and dried must do granule；After granule granulate, spray volatile oil, airtight placement one
The section time；Add appropriate auxiliary materials and mixing, or be not added with adjuvant, encapsulating capsule, to obtain final product.The middle promulgated by the State Council of Publication No. CN1364479
Bright patent application, discloses a kind of nano gastrodia tuber and fleece-flower root medicine, it be with nano gastrodia, nano angelica root, nanometer Radix Polygoni Multiflori,
Nanometer Radix Rehmanniae Preparata, nano red sage, nanometer Rhizoma Chuanxiong, nano Chinese angelica, nanometer stir-baked FRUCTUS TRIBULI, nanometer Folium Mori, nano-ink Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae), nanometer Fructus Ligustri Lucidi
Son, the nanometer Radix Paeoniae Alba, nanometer Rhizoma Polygonati, nanometer Radix Glycyrrhizae are raw material, prepare in proportion, make new pharmaceutical preparation, and its fineness of the particles reaches
1200-1500 mesh, particle diameter is 0.1-200nm, and wherein overwhelming majority particle diameter is less than 100nm, and has new physical property.Use micro-
The steps such as ripple extraction, concentrating under reduced pressure, supersonic jet technology spray drying are made.The Chinese invention of Publication No. CN1726931
Patent application discloses the preparation method of a kind of gastrodia tuber and fleece-flower root medicine, and its drug main will be by Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori, Radix Angelicae Sinensis, white
The root of Dahurian angelica, Radix Rehmanniae Preparata, Herba Ecliptae, Rhizoma Polygonati, Radix Salviae Miltiorrhizae, stir-baked FRUCTUS TRIBULI, Fructus Ligustri Lucidi, Radix Glycyrrhizae, Folium Mori, the Radix Paeoniae Alba etc. form, the consumption model of each composition
Enclose be respectively Rhizoma Gastrodiae be 3～7%, Rhizoma Chuanxiong 0.5～3%, Radix Polygoni Multiflori be 7～10%, when be classified as 7～10%, the Radix Angelicae Dahuricae be 3～7%,
Radix Rehmanniae Preparata be 7～10%, Herba Ecliptae be 7～10%, Rhizoma Polygonati be 10～13%, Radix Salviae Miltiorrhizae be 7～10%, stir-baked FRUCTUS TRIBULI be 3～7%,
Fructus Ligustri Lucidi 10～13%, Radix Glycyrrhizae 0.5～3%, Folium Mori be 3～7%, the Radix Paeoniae Alba be 10～13%.This process for preparing medicine is to take sky
Fiber crops, Rhizoma Chuanxiong, Radix Polygoni Multiflori powder be broken into fine powder, sieve, mix, standby；Take the medicinal residues after Radix Angelicae Sinensis, Radix Angelicae Dahuricae extraction volatile oil each with remaining
Medicine extracting in water 2～3 times, each 60～180 minutes, united extraction liquid, filter, be spray dried to extractum after filtrate reduced in volume
Powder, adds above-mentioned medicated powder and volatile oil, mixing, adds various excipient and makes Chinese medicine preparation.In the above prior art, it uses
Radix Polygoni Multiflori there is the side effect of laxation, thus cause gastrodia tuber and fleece-flower root medicine to there is potential untoward reaction, consumer's food for a long time it
After, the colony of some easy gastrointestinal upsets can produce the side effect of diarrhoea stomachache.The Fructus Ligustri Lucidi used in prior art, at this medicine
In composition formula, its oils and fats can be overflowed, thus cause the cold sliding characteristic of gastrodia tuber and fleece-flower root medicine band, have relatively first mate to make Deficiency and coldness of spleen and stomach person
With, increase the weight of its deficiency and coldness and have loose bowels.The Rhizoma Polygonati used in prior art, taste is sweet, but has fiber crops taste concurrently simultaneously, thus causes gastrodia tuber and fleece-flower root
Medicine has excitement to throat, often feels like discomfort when making to take.
Summary of the invention
For overcoming existing gastrodia tuber and fleece-flower root side effects of pharmaceutical drugs problem and reaching more effective therapeutic effect, the present invention provides one
Kind novel Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition.Prior art is improved by the present invention, on the basis of tradition hospital
On, have employed Radix Polygoni Multiflori Preparata, Fructus Ligustri Lucidi (system), the scheme of Rhizoma Polygonati (system).Overcome tradition hospital be easily caused user diarrhoea and
The problem of throat discomfort.
The Rhizoma Gastrodiae of the present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition are prepared by raw material or the flavour of a drug of following weight:
Rhizoma Gastrodiae 2-8 part, Radix Angelicae Dahuricae 2-6 part, Radix Polygoni Multiflori Preparata 5-10 part, Radix Rehmanniae Preparata 5-10 part, Radix Salviae Miltiorrhizae 5-10 part, Rhizoma Chuanxiong
1-6 part, Herba Ecliptae 7-14 part, Fructus Ligustri Lucidi (system) 7-14 part, Radix Paeoniae Alba 7-14 part, Rhizoma Polygonati (system) 7-14 part, Radix Glycyrrhizae 1-5
Part, Radix Angelicae Sinensis 7-14 part, Folium Mori 3-8 part, stir-baked FRUCTUS TRIBULI 3-8 part.
Another preferred version of the present invention is, on the basis of such scheme, by raw material or the medicine of following weight
Taste prepares:
Rhizoma Gastrodiae 3-8 part, Radix Angelicae Dahuricae 2-5 part, Radix Polygoni Multiflori Preparata 6-9 part, Radix Rehmanniae Preparata 6-9 part, Radix Salviae Miltiorrhizae 6-9 part, Rhizoma Chuanxiong 2-5
Part, Herba Ecliptae 8-12 part, Fructus Ligustri Lucidi (system) 8-12 part, Radix Paeoniae Alba 8-12 part, Rhizoma Polygonati (system) 8-12 part, Radix Glycyrrhizae 1-4 part, when
Return 8-12 part, Folium Mori 4-7 part, stir-baked FRUCTUS TRIBULI 4-7 part.
Another preferred version of the present invention is, on the basis of such scheme, by raw material or the medicine of following weight
Taste prepares:
Rhizoma Gastrodiae 3.5-6 part, Radix Angelicae Dahuricae 3-5 part, Radix Polygoni Multiflori Preparata 7-9 part, Radix Rehmanniae Preparata 7-9 part, Radix Salviae Miltiorrhizae 7-9 part, Rhizoma Chuanxiong
2-4 part, Herba Ecliptae 8.5-11.5 part, Fructus Ligustri Lucidi (system) 10-12 part, Radix Paeoniae Alba 10-12 part, Rhizoma Polygonati (system) 8.5-12 part, sweet
Grass 1-2.5 part, Radix Angelicae Sinensis 8.5-11.5 part, Folium Mori 4-6.5 part, stir-baked FRUCTUS TRIBULI 4-6.5 part.
Another preferred version of the present invention is, on the basis of such scheme, by raw material or the medicine of following weight
Taste prepares:
Rhizoma Gastrodiae 4-5 part, Radix Angelicae Dahuricae 3-4 part, Radix Polygoni Multiflori Preparata 7-8 part, Radix Rehmanniae Preparata 7-8 part, Radix Salviae Miltiorrhizae 7-8 part, Rhizoma Chuanxiong 3-4
Part, Herba Ecliptae 10-11 part, Fructus Ligustri Lucidi (system) 10-11 part, Radix Paeoniae Alba 10-11 part, Rhizoma Polygonati (system) 10-11 part, Radix Glycyrrhizae 1-2
Part, Radix Angelicae Sinensis 10-11 part, Folium Mori 5-6 part, stir-baked FRUCTUS TRIBULI 5-6 part.
Another preferred version of the present invention is, on the basis of such scheme, by raw material or the medicine of following weight
Taste prepares:
Rhizoma Gastrodiae 4.5-5.7 part, Radix Angelicae Dahuricae 3.5-4.8 part, Radix Polygoni Multiflori Preparata 7.3-8.5 part, Radix Rehmanniae Preparata 7.5-8.8 part, pellet
Ginseng 6.5-7.9 part, Rhizoma Chuanxiong 2.8-3.5 part, Herba Ecliptae 9.5-11 part, Fructus Ligustri Lucidi (system) 10-11.4 part, Radix Paeoniae Alba 9.8-
11.3 parts, Rhizoma Polygonati (system) 10.5-11.3 part, Radix Glycyrrhizae 1.5-2.2 part, Radix Angelicae Sinensis 10.5-11.3 part, Folium Mori 4.5-5.5 part, stir-fry
Fructus Tribuli 4.5-5.5 part.
Another preferred version of the present invention is, on the basis of such scheme, by raw material or the medicine of following weight
Taste prepares:
Rhizoma Gastrodiae 4.5-5.5 part, Radix Angelicae Dahuricae 2.5-3.8 part, Radix Polygoni Multiflori Preparata 6.5-8 part, Radix Rehmanniae Preparata 6.8-8 part, Radix Salviae Miltiorrhizae
6.8-8 part, Rhizoma Chuanxiong 3-3.5 part, Herba Ecliptae 10.5-11.5 part, Fructus Ligustri Lucidi (system) 10.5-11.5 part, Radix Paeoniae Alba 10.5-
11.5 parts, Rhizoma Polygonati (system) 10.5-11.5 part, Radix Glycyrrhizae 1.2-1.6 part, Radix Angelicae Sinensis 10-10.6 part, Folium Mori 5.2-5.8 part, fry puncture
Herba chenopodii 5.2-5.8 part.
Another preferred version of the present invention is, on the basis of such scheme, by raw material or the medicine of following weight
Taste prepares:
Rhizoma Gastrodiae 4.3-4.8 part, Radix Angelicae Dahuricae 3.6-4.1 part, Radix Polygoni Multiflori Preparata 7.7-8.9 part, Radix Rehmanniae Preparata 7.7-8.9 part, pellet
Ginseng 7.7-8.9 part, Rhizoma Chuanxiong 2.8-3.2 part, Herba Ecliptae 10-10.6 part, Fructus Ligustri Lucidi (system) 10-10.6 part, Radix Paeoniae Alba 10-
10.6 parts, Rhizoma Polygonati (system) 10-10.6 part, Radix Glycyrrhizae 1.5-1.8 part, Radix Angelicae Sinensis 10.4-11 part, Folium Mori 4.8-5.3 part, stir-baked FRUCTUS TRIBULI
4.8-5.3 part.
The present invention also provides for described Rhizoma Gastrodiae, the preparation method of Radix Polygoni Multiflori Preparata pharmaceutical composition, and its scheme is:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 1-3 time, each 1.5-2.5 hour, decocting liquid filtered, then by filtrate
Merge, be condensed into extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
Wherein, it is highly preferred that
Step (3) boiling 2 times, each 2 hours.
When step (4) makes granule, pharmaceutically acceptable adjuvant can be added.
Step (5) may be made as pill, granule, microcapsule, drop pill, slow releasing agent, controlled release agent, mixture, injection etc..
Rhizoma Gastrodiae, formal name used at school: Gastrodia elata Bl.), have another name called rhizoma gastrodiae, solely shake sesame, from female, close and superintend and direct from grass, SHENCAO, ghost
Postal, Mokpo, RHIZONA GASTRODIAE, DINGFENGCAO, Bai Longpi etc., be the orchid family Gastrodia herbaceos perennial.Block stem is plump, without greenery,
The capsule shape of falling ovum is oval, its tuber be used as medicine to treat have a dizzy spell, the disease such as numb limbs and tense tendons, infantile convulsion.Property sweet flat, return liver
Warp.In inventive formulation, being all monarch drug with Radix Polygoni Multiflori Preparata, performance treatment is had a dizzy spell, the effect of nourishing the liver and kidney.
Radix Polygoni Multiflori is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., slightly warm in nature,
Bitter in the mouth, sweet, puckery, return liver, the heart, kidney channel, tool removing toxic substances, eliminating carbuncle, the function of loosening bowel to relieve constipation.
Radix Polygoni Multiflori Preparata, for the Preparation process product of Radix Polygoni Multiflori, after concocting by pharmacopeia, the block sheet in irregular shrunk, thickness is about
1CM, surface pitchy or sepia, uneven, matter is hard, section cutin sample.Feeble QI, taste is micro-sweet and pained.In the present invention
Formula in, be also monarch drug, there is the function of invigorating the liver and kidney, benefiting essence-blood, can treat because of deficiency of the liver and kindey, essence and blood loss and the waist that causes
Knees soreness, vertigo and tinnitus, early whitening of beard and hair etc..
The Radix Angelicae Dahuricae (Latin literary fame: Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.ex
Franch.et Sav), property is pungent, temperature, returns stomach, large intestine, lung meridian, is used as medicine with root, has relieving exterior syndrome and dispelling cold, dispel the wind in inventive formulation
The functions such as pain relieving, dampness leukorrhagia stopping, detumescence and apocenosis.
Radix Rehmanniae Preparata is the Preparation process product of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), has another name called Radix Rehmanniae Preparata
Or throw oneself on the ground, property is sweet, tepor, returns liver, kidney channel, in inventive formulation, has the effect of yin nourishing of enriching blood, life essence-filling, marrow-benefitting.
Radix Salviae Miltiorrhizae, for dry root and the rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Bitter in the mouth, property is micro-
Cold；GUIXIN, Liver Channel.There is in inventive formulation promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the effect of the relieving restlessness that clears away heart-fire.
Rhizoma Chuanxiong, for the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong hort..Acrid in the mouth, warm in nature,
Returning liver, gallbladder, pericardium channel, gas perfume (or spice) liter is dispersed in inventive formulation has blood-activating and qi-promoting, effect of wind-expelling pain-stopping.
Herba Ecliptae: English entitled Herba Ecluptae, doing for feverfew Eclipta prostrata Eclipta prostrata L.
Dry aerial parts, sweet in the mouth, acid, cold, return kidney, Liver Channel, inventive formulation has nourishing the liver and kidney, effect of cooling blood for hemostasis.
Fructus Ligustri Lucidi, another name Fructus Ligustri Lucidi reality, Fructus Ilicis Purpureae, wax tree, Mus Chinese catalpa, for Oleaceae plants Fructus Ligustri Lucidi Ligustrum
The dry mature fruit of lucidum Ait..Property is sweet, bitter, cool, returns liver, kidney channel.Curing mainly dizziness dizzy, soreness of the waist and knees, beard and hair is early
In vain, poor vision, interior-heat is quenched one's thirst.
Fructus Ligustri Lucidi (system) is the flavour of a drug that Fructus Ligustri Lucidi passes through that processed with wine, salt system or the process of preparing Chinese medicine of other concocting methods are later, with processed with wine, salt
After system or additive method were concocted, enhance the absorbability of medicine, and avoid the oiliness shadow to drug effect of Fructus Ligustri Lucidi
Ring and the stimulation of cold empty body constitution.Fructus Ligustri Lucidi (system) has nourishing the liver and kidney, effect of improving eyesight black hair in the present invention.
The Radix Paeoniae Alba (formal name used at school: Paeonia lactiflora Pall.) is also referred to as Paeonia sterniana Fletcher in Journ., is Ranunculaceae Paeonia plant.Taste
Bitter, sour, cold nature, return liver, spleen channel.In the present invention, have enrich blood, effect of yin fluid astringing easing the affected liver, relieving spasm to stop pain.
Rhizoma Polygonati (formal name used at school: Polygonatum sibiricum), has another name called: polygonatum sibiricum Redoute, yellow chicken dish, shaft of a writing brush dish, claw ginseng,
Rhizoma Polygonati Cirrhifolii, JIZHUASHEN.For HUANGJING ZANYU CAPSULE, rhizome horizontal walk, cylindric, tuberosity expands.Impeller is raw, stockless.Sweet in the mouth, property is put down, is returned
Spleen, lung, kidney channel, have spleen reinforcing, the effect of the lung moistening and production of body fluid promoting.
Rhizoma Polygonati (is made), steams through wine or water for Rhizoma Polygonati, or gained after the additive method process of preparing Chinese medicine, sweet in the mouth, and property is put down, returned lung, spleen, kidney
Warp, has nourishing kidney lung moistening in the present invention, effect of invigorating the spleen and replenishing QI.Rhizoma Polygonati (system) overcomes the throat discomfort caused by Rhizoma Polygonati
Problem.
Radix Glycyrrhizae (formal name used at school: Glycyrrhiza uralensis Fisch) is called: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet
Son.Pulse family, Glycyrrhiza perennial herb, play the effect of coordinating the actions of various ingredients in a prescription in the present invention.
Radix Angelicae Sinensis (formal name used at school: Angelica sinensis (Oliv.) Diels) call dry return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis,
Radix Angelicae Sinensis, Radix Angelicae Sinensis body, culvert Radix Angelicae Sinensis, Radix Angelicae Sinensis are bent, Radix Angelicae Gigatis, perennial herb.Sweet, pungent, warm, return liver, the heart, spleen channel.In the present invention
In have enrich blood, effect of invigorating blood circulation.
Folium Mori (Mulberry Leaf), formal name used at school: Folium Mori.It is being dried of moraceae plants Mulberry Morus alba L.
Leaf.Cold in nature, bitter in the mouth, sweet, return lung, Liver Channel.In the present invention, there is clearing away lung-heat and moistening for dryness, effect of suppressing the hyperactive liver improving eyesight.
Fructus Tribuli, for the dry mature fruit of zygophyllaceae plant Fructus Tribuli Tribulus terrestris L.., another name: Fructus Tribuli
Son, bypass, bend people, only row, jackal plumage, rise push away, i.e. Herba chenopodii, Fructus Atriplicis Sibiricae, society Fructus Tribuli soil Fructus Tribuli, Fructus Atriplicis Sibiricae, non-irrigated grass, triangle Fructus Tribuli,
Three Fructus Gleditsia acupuncture, anistree thorn, puncture frame, open country Pedicellus et Pericarpium Trapae, Pedicellus et Pericarpium Trapae, hard puncture multitude, puncture multitude, Fructus Tribuli Canis familiaris L., Qi Lidan, Tuo Luoci, Pedicellus et Pericarpium Trapae
Thorn, Fructus Tribuli.Pungent, bitter, tepor, returns Liver Channel.Cure mainly headache dizziness, sternal rib pain etc..
Stir-baked FRUCTUS TRIBULI is that Fructus Tribuli is fried to slightly yellow by official method, has suppressing the hyperactive liver resolving depression, the merit of wind of invigorating blood circulation in the present invention
Effect.
The present invention compared with prior art, overcomes existing gastrodia tuber and fleece-flower root medicine and causes the problem of diarrhoea and throat discomfort,
Promote effective absorption of medicine, decrease side effect.In the present invention, Rhizoma Gastrodiae is sweet flat, and kind suppressing the hyperactive liver to relieve the wind syndrome, removing obstruction in the collateral to relieve pain, system how
Radix Polygoni Multiflori nourishing the liver and kidney, benefit lean blood, blackening and generating hair, two medicines share, both nourishing blood for calming endogenous wind, again fixed dizzy pain relieving, therefore are monarch drug.Radix Rehmanniae Preparata
Huang, Herba Ecliptae, Fructus Ligustri Lucidi (system), Rhizoma Polygonati (system), Radix Angelicae Sinensis nourishing the liver and kidney, nourishing YIN of nourishing blood；The Radix Paeoniae Alba, Folium Mori, stir-baked FRUCTUS TRIBULI nourish blood yin fluid astringing,
Suppressing the hyperactive liver pain relieving, is ministerial drug altogether.Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae adjust smooth QI and blood, above reach the head, wind-expelling pain-stopping, are adjuvant drug altogether.Radix Glycyrrhizae is in harmonious proportion
All medicines, for making medicine.All medicines match, and play the effect of nourishing the liver and kidney, nourishing blood for calming endogenous wind altogether.
Detailed description of the invention
It is exemplified below some preferred embodiments of the present invention, to help being further appreciated by the present invention, but the scope of the present invention
It is not limited thereto.
1, the processing procedure of Radix Polygoni Multiflori Preparata: take Radix Polygoni Multiflori pieces or block, according to stewing method (" Chinese Pharmacopoeia " 2015 editions four general rules
0213) mix thoroughly with decoction of black soybean, be placed in the container of non iron, stew to juice exhaustion；Or according to steaming method (" Chinese Pharmacopoeia " 2015 editions four
Portion's general rule 0213), steam after steaming in clear soup or mixing thoroughly with decoction of black soybean, steam to the most inside and outside all in sepia, or shine the most half-dried, section, it is dried.
Processing action: strengthen invigorating the liver and kidney effect, removes laxation effect.
2, the processing procedure of Fructus Ligustri Lucidi (system): use processed with wine or salt system
2.1 wine Fructus Ligustri Lucidi: take Fructus Ligustri Lucidi, steam method (" Chinese Pharmacopoeia " 2015 editions four general rules 0213) according to stewed with wine method or wine and stew
Exhaust to wine or steam thoroughly.
2.2 salt Fructus Ligustri Lucidi: according to method of stir-baking medicine with salt solu-tion (" Chinese Pharmacopoeia " 2015 editions four general rules 0213), heat with slow fire, fry to rule
When determining degree, take out, cool.
Processing action: increase effective ingredient dissolution, changes the slip of Fructus Ligustri Lucidi oils and fats, and strengthens benefiting action.
3, the processing procedure of Rhizoma Polygonati (processed): use stir-baked RHIZOMA POLYGONATI with yellow rice wine or Rhizoma Polygonati (steamed)
3.1 stir-baked RHIZOMA POLYGONATI with yellow rice wine: take Rhizoma Polygonati, according to stewed with wine method or wine steam method (" Chinese Pharmacopoeia " 2015 editions four general rules 0213) stew thoroughly or
Steam thoroughly, slightly dry in the air, cut sheet, be dried.
3.2 Rhizoma Polygonati (steamed): take Rhizoma Polygonati, steam to inside and outside in taste repeatedly according to the method for steaming (" Chinese Pharmacopoeia " 2015 editions four general rules 0213)
Profit black, takes out, slightly dries in the air, cut sheet, is dried.
Processing action: spleen reinforcing lung moistening kidney tonifying effect can be strengthened, and remove fiber crops taste, it is to avoid stimulate throat during taking.
The Rhizoma Gastrodiae of embodiment 1 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
4.5 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 3.5 parts, Radix Polygoni Multiflori Preparata 7.3 parts, Radix Rehmanniae Preparata 7.5 parts, Radix Salviae Miltiorrhizae 6.5 parts, Rhizoma Chuanxiong 2.8 parts, ink
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 9.5 parts, Fructus Ligustri Lucidi (system) 10 parts, the Radix Paeoniae Alba 9.8 parts, Rhizoma Polygonati (system) 10.5 parts, 1.5 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 10.5 parts, Folium Mori
4.5 parts, stir-baked FRUCTUS TRIBULI 4.5 parts.
Preparation method is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 2 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
4.8 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 4.1 parts, Radix Polygoni Multiflori Preparata 8.9 parts, Radix Rehmanniae Preparata 8.9 parts, Radix Salviae Miltiorrhizae 8.9 parts, Rhizoma Chuanxiong 3.2 parts, ink
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 10.6 parts, Fructus Ligustri Lucidi (system) 10.6 parts, the Radix Paeoniae Alba 10.6 parts, Rhizoma Polygonati (system) 10.6 parts, 1.8 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 11 parts, Folium Mori
5.3 parts, stir-baked FRUCTUS TRIBULI 5.3 parts.
Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition preparation method as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 3 times, each 1.5 hours, collecting decoction, filter, then filtrate is dense
Shorten extractum into；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 3 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
4.5 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 2.5 parts, Radix Polygoni Multiflori Preparata 6.5 parts, Radix Rehmanniae Preparata 6.8 parts, Radix Salviae Miltiorrhizae 6.8 parts, Rhizoma Chuanxiong 3 parts, ink drought
10.5 parts of lotus, Fructus Ligustri Lucidi (system) 10.5 parts, the Radix Paeoniae Alba 10.5 parts, Rhizoma Polygonati (system) 10.5 parts, 1.2 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 10 parts, Folium Mori
5.2 parts, stir-baked FRUCTUS TRIBULI 5.2 parts.
Its preparation methods steps is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2.5 hours, decocting liquid filtered, then filtrate was merged, dense
Shorten extractum into；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 4 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
5.5 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 3.8 parts, Radix Polygoni Multiflori Preparata 8 parts, Radix Rehmanniae Preparata 8 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 3.5 parts, Herba Ecliptae
11.5 parts, Fructus Ligustri Lucidi (system) 11.5 parts, the Radix Paeoniae Alba 11.5 parts, Rhizoma Polygonati (system) 11.5 parts, 1.6 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 10.6 parts, Folium Mori
5.8 parts, stir-baked FRUCTUS TRIBULI 5.8 parts.
Described Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition preparation method step as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 5 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
4.5 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 4.8 parts, Radix Polygoni Multiflori Preparata 7.3 parts, Radix Rehmanniae Preparata 7.5 parts, Radix Salviae Miltiorrhizae 7.9 parts, Rhizoma Chuanxiong 2.8 parts, ink
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 10 parts, Fructus Ligustri Lucidi (system) 10 parts, the Radix Paeoniae Alba 9.8 parts, Rhizoma Polygonati (system) 10.5 parts, 1.5 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 11.3 parts, Folium Mori 4.5
Part, stir-baked FRUCTUS TRIBULI 4.5 parts.
Rhizoma Gastrodiae of the present invention, the preparation method of Radix Polygoni Multiflori Preparata pharmaceutical composition, the steps include:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 6 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
5.7 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 4.7 parts, Radix Polygoni Multiflori Preparata 8.5 parts, Radix Rehmanniae Preparata 7.5 parts, Radix Salviae Miltiorrhizae 6.5 parts, Rhizoma Chuanxiong 3.5 parts, ink
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 11 parts, Fructus Ligustri Lucidi (system) 11.4 parts, the Radix Paeoniae Alba 9.9 parts, Rhizoma Polygonati (system) 11.3 parts, 2.1 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 10.5 parts, Folium Mori
4.5 parts, stir-baked FRUCTUS TRIBULI 5.5 parts.
Described Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition preparation method step as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by volatile oil and pharmaceutically acceptable auxiliary materials and mixing, airtight rear filler capsule or the pressure of granule and step (2)
Sheet.
The Rhizoma Gastrodiae of embodiment 7 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
4 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 3 parts, Radix Polygoni Multiflori Preparata 7.5 parts, Radix Rehmanniae Preparata 8 parts, Radix Salviae Miltiorrhizae 7 parts, Rhizoma Chuanxiong 3.8 parts, Herba Ecliptae 10.6
Part, Fructus Ligustri Lucidi (system) 10.9 parts, the Radix Paeoniae Alba 10.8 parts, Rhizoma Polygonati (system) 10 parts, 1 part of Radix Glycyrrhizae, Radix Angelicae Sinensis 10 parts, 6 parts of Folium Mori, stir-baked FRUCTUS TRIBULI 6
Part.
Preparation method is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 8 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
5 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 3.9 parts, Radix Polygoni Multiflori Preparata 8 parts, Radix Rehmanniae Preparata 8 parts, Radix Salviae Miltiorrhizae 7 parts, Rhizoma Chuanxiong 4 parts, Herba Ecliptae 10 parts, female
Loyal son (system) 11 parts, the Radix Paeoniae Alba 11 parts, Rhizoma Polygonati (system) 1 part, 2 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 10 parts, 5 parts of Folium Mori, stir-baked FRUCTUS TRIBULI 5.5 parts.
Preparation method is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2.5 hours, decocting liquid filtered, then filtrate was merged, dense
Shorten extractum into；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 9 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
3.5 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 3 parts, Radix Polygoni Multiflori Preparata 7 parts, Radix Rehmanniae Preparata 7 parts, Radix Salviae Miltiorrhizae 7 parts, Rhizoma Chuanxiong 2 parts, Herba Ecliptae 8.5 parts,
Fructus Ligustri Lucidi (system) 10 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Polygonati (system) 8.5 parts, 1 part of Radix Glycyrrhizae, Radix Angelicae Sinensis 8.5 parts, 4 parts of Folium Mori, stir-baked FRUCTUS TRIBULI 6.5 parts.
Preparation method is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 1.5 hours, decocting liquid filtered, then filtrate was merged, dense
Shorten extractum into；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 10 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
6 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 5 parts, Radix Polygoni Multiflori Preparata 9 parts, Radix Rehmanniae Preparata 9 parts, Radix Salviae Miltiorrhizae 9 parts, Rhizoma Chuanxiong 4 parts, Herba Ecliptae 11.5 parts, female
Loyal son (system) 12 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Polygonati (system) 12 parts, 2.5 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 11.5 parts, 6.5 parts of Folium Mori, stir-baked FRUCTUS TRIBULI 4 parts.
Preparation method is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 11 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
3 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 2 parts, Radix Polygoni Multiflori Preparata 6 parts, Radix Rehmanniae Preparata 6 parts, Radix Salviae Miltiorrhizae 6 parts, Rhizoma Chuanxiong 2 parts, Herba Ecliptae 8 parts, Fructus Ligustri Lucidi
Son (system) 8 parts, the Radix Paeoniae Alba 8 parts, Rhizoma Polygonati (system) 8 parts, 1 part of Radix Glycyrrhizae, Radix Angelicae Sinensis 8 parts, 4 parts of Folium Mori, stir-baked FRUCTUS TRIBULI 4 parts.
Preparation method is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The Rhizoma Gastrodiae of embodiment 12 present invention, Radix Polygoni Multiflori Preparata pharmaceutical composition
Take the raw material of following weight:
8 parts of Rhizoma Gastrodiae, the Radix Angelicae Dahuricae 5 parts, Radix Polygoni Multiflori Preparata 9 parts, Radix Rehmanniae Preparata 9 parts, Radix Salviae Miltiorrhizae 9 parts, Rhizoma Chuanxiong 5 parts, Herba Ecliptae 12 parts, Fructus Ligustri Lucidi
Son (system) 12 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Polygonati (system) 12 parts, 4 parts of Radix Glycyrrhizae, Radix Angelicae Sinensis 12 parts, 7 parts of Folium Mori, stir-baked FRUCTUS TRIBULI 7 parts.
Preparation method is as follows:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Huang
Essence (system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 2 times, each 2 hours, decocting liquid filtered, then filtrate was merged, and concentrated
Become extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The pharmaceutical composition of the present invention, can be used for treating the hepatic and renal YIN deficiency disease of the symptoms such as headache, dizziness, alopecia, poliosis,
After filler capsule or tabletting, according to symptom degree, it is proposed that dose is 2.5-4.5 gram/day, it it was a course for the treatment of with 30 days.Through clinic
Treat 577 examples headache patients with vertigo, one the course for the treatment of symptom alleviate 351 examples that reach being clearly better, separately have 212 examples after two courses for the treatment of
Also occurring being clearly better, effective percentage reaches more than 97%.The untoward reaction such as diarrhoea occurs in none example, throat twinge.And press
The gastrodia tuber and fleece-flower root agent that technology disclosed in CN1583056 prepares, after taking, is only clearly better rate in 300 example patient two courses for the treatment of
The user having nearly 45% in about 70%, and user occurs that slight or heavier diarrhoea, about 28% user are felt
Throat discomfort；The gastrodia tuber and fleece-flower root agent that technology as disclosed in CN1726931 prepares, after taking, bright in 300 example patient two courses for the treatment of
There is the user of nearly 38% that slight or heavier diarrhoea occurs in aobvious improvement rate only about 75%, and user, about 30%
User feels throat discomfort.Visible, the medicine of the present invention overcomes the diarrhoea caused by prior art, throat discomfort the most completely
Etc. problem, and more utilizing patient to absorb, effective percentage is also greatly promoted.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, simplify,
All should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (10)
1. Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, the raw material including following weight prepare:
Rhizoma Gastrodiae 2-8 part, Radix Angelicae Dahuricae 2-6 part, Radix Polygoni Multiflori Preparata 5-10 part, Radix Rehmanniae Preparata 5-10 part, Radix Salviae Miltiorrhizae 5-10 part, Rhizoma Chuanxiong 1-6
Part, Herba Ecliptae 7-14 part, Fructus Ligustri Lucidi (system) 7-14 part, Radix Paeoniae Alba 7-14 part, Rhizoma Polygonati (system) 7-14 part, Radix Glycyrrhizae 1-5 part, when
Return 7-14 part, Folium Mori 3-8 part, stir-baked FRUCTUS TRIBULI 3-8 part.
The most according to claim 1, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, by including following weight
Raw material prepare:
Rhizoma Gastrodiae 3-8 part, Radix Angelicae Dahuricae 2-5 part, Radix Polygoni Multiflori Preparata 6-9 part, Radix Rehmanniae Preparata 6-9 part, Radix Salviae Miltiorrhizae 6-9 part, Rhizoma Chuanxiong 2-5 part,
Herba Ecliptae 8-12 part, Fructus Ligustri Lucidi (system) 8-12 part, Radix Paeoniae Alba 8-12 part, Rhizoma Polygonati (system) 8-12 part, Radix Glycyrrhizae 1-4 part, Radix Angelicae Sinensis
8-12 part, Folium Mori 4-7 part, stir-baked FRUCTUS TRIBULI 4-7 part.
The most according to claim 1, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, by including following weight
Raw material prepare:
Rhizoma Gastrodiae 3.5-6 part, Radix Angelicae Dahuricae 3-5 part, Radix Polygoni Multiflori Preparata 7-9 part, Radix Rehmanniae Preparata 7-9 part, Radix Salviae Miltiorrhizae 7-9 part, Rhizoma Chuanxiong 2-4
Part, Herba Ecliptae 8.5-11.5 part, Fructus Ligustri Lucidi (system) 10-12 part, Radix Paeoniae Alba 10-12 part, Rhizoma Polygonati (system) 8.5-12 part, Radix Glycyrrhizae
1-2.5 part, Radix Angelicae Sinensis 8.5-11.5 part, Folium Mori 4-6.5 part, stir-baked FRUCTUS TRIBULI 4-6.5 part.
The most according to claim 1, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, by including following weight
Raw material prepare:
Rhizoma Gastrodiae 4-5 part, Radix Angelicae Dahuricae 3-4 part, Radix Polygoni Multiflori Preparata 7-8 part, Radix Rehmanniae Preparata 7-8 part, Radix Salviae Miltiorrhizae 7-8 part, Rhizoma Chuanxiong 3-4 part,
Herba Ecliptae 10-11 part, Fructus Ligustri Lucidi (system) 10-11 part, Radix Paeoniae Alba 10-11 part, Rhizoma Polygonati (system) 10-11 part, Radix Glycyrrhizae 1-2 part, when
Return 10-11 part, Folium Mori 5-6 part, stir-baked FRUCTUS TRIBULI 5-6 part.
The most according to claim 1, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, by including following weight
Raw material prepare:
Rhizoma Gastrodiae 4.5-5.7 part, Radix Angelicae Dahuricae 3.5-4.8 part, Radix Polygoni Multiflori Preparata 7.3-8.5 part, Radix Rehmanniae Preparata 7.5-8.8 part, Radix Salviae Miltiorrhizae
6.5-7.9 part, Rhizoma Chuanxiong 2.8-3.5 part, Herba Ecliptae 9.5-11 part, Fructus Ligustri Lucidi (system) 10-11.4 part, Radix Paeoniae Alba 9.8-11.3
Part, Rhizoma Polygonati (system) 10.5-11.3 part, Radix Glycyrrhizae 1.5-2.2 part, Radix Angelicae Sinensis 10.5-11.3 part, Folium Mori 4.5-5.5 part, stir-baked FRUCTUS TRIBULI
4.5-5.5 part.
The most according to claim 1, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, by including following weight
Raw material prepare:
Rhizoma Gastrodiae 4.5-5.5 part, Radix Angelicae Dahuricae 2.5-3.8 part, Radix Polygoni Multiflori Preparata 6.5-8 part, Radix Rehmanniae Preparata 6.8-8 part, Radix Salviae Miltiorrhizae 6.8-8
Part, Rhizoma Chuanxiong 3-3.5 part, Herba Ecliptae 10.5-11.5 part, Fructus Ligustri Lucidi (system) 10.5-11.5 part, Radix Paeoniae Alba 10.5-11.5 part, Huang
Essence (system) 10.5-11.5 part, Radix Glycyrrhizae 1.2-1.6 part, Radix Angelicae Sinensis 10-10.6 part, Folium Mori 5.2-5.8 part, stir-baked FRUCTUS TRIBULI 5.2-
5.8 part.
The most according to claim 1, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, by including following weight
Raw material prepare:
Rhizoma Gastrodiae 4.3-4.8 part, Radix Angelicae Dahuricae 3.6-4.1 part, Radix Polygoni Multiflori Preparata 7.7-8.9 part, Radix Rehmanniae Preparata 7.7-8.9 part, Radix Salviae Miltiorrhizae
7.7-8.9 part, Rhizoma Chuanxiong 2.8-3.2 part, Herba Ecliptae 10-10.6 part, Fructus Ligustri Lucidi (system) 10-10.6 part, Radix Paeoniae Alba 10-10.6
Part, Rhizoma Polygonati (system) 10-10.6 part, Radix Glycyrrhizae 1.5-1.8 part, Radix Angelicae Sinensis 10.4-11 part, Folium Mori 4.8-5.3 part, stir-baked FRUCTUS TRIBULI
4.8-5.3 part.
8. Rhizoma Gastrodiae, the preparation method of Radix Polygoni Multiflori Preparata pharmaceutical composition described in claim 1 to 7 any one claim, it is special
Levy and be, comprise the following steps:
(1) Rhizoma Gastrodiae, Rhizoma Chuanxiong, Radix Polygoni Multiflori Preparata are ground into powder；
(2) take Radix Angelicae Sinensis, the Radix Angelicae Dahuricae extracts volatile oil；
(3) step (2) is extracted the medicinal residues after volatile oil and Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi (system), the Radix Paeoniae Alba, Rhizoma Polygonati
(system), Radix Glycyrrhizae, Folium Mori, stir-baked FRUCTUS TRIBULI mixing, boiling 1-3 time, each 1.5-2.5 hour, decocting liquid filtered, then filtrate was closed
And, it is condensed into extractum；
(4) by the powder mixing of extractum with step (1), dry, pulverize into dried cream powder, make granule the most again；
(5) by granule and the volatile oil mixing of step (2), airtight rear filler capsule or tabletting.
The most according to claim 8, Rhizoma Gastrodiae, the preparation method of Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, step (3) adds water
Decoct 2 times, each 2 hours.
The most according to claim 8, Rhizoma Gastrodiae, the preparation method of Radix Polygoni Multiflori Preparata pharmaceutical composition, is characterized in that, step (4) is made
When becoming granule, pharmaceutically acceptable adjuvant can be added.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107164180A (en) * | 2017-06-06 | 2017-09-15 | 福建省泽弘智能机械有限公司 | It is a kind of to alleviate medicinal liquor of headache and dizzy and preparation method thereof |
| CN114712457A (en) * | 2022-04-15 | 2022-07-08 | 广东省皮发毛医学研究中心 | Chinese medicinal composition for treating hair diseases and preparation method thereof |
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| CN1583056A (en) * | 2004-06-16 | 2005-02-23 | 黄宏彬 | Gastrodia tuber and fleece-flower root preparation and its preparing method |
| CN1726931A (en) * | 2004-07-28 | 2006-02-01 | 湖南德海制药有限公司 | Method for preparing medication of gastrodia tuber and tuber of multiflower knotweed |
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| CN1583056A (en) * | 2004-06-16 | 2005-02-23 | 黄宏彬 | Gastrodia tuber and fleece-flower root preparation and its preparing method |
| CN1726931A (en) * | 2004-07-28 | 2006-02-01 | 湖南德海制药有限公司 | Method for preparing medication of gastrodia tuber and tuber of multiflower knotweed |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107164180A (en) * | 2017-06-06 | 2017-09-15 | 福建省泽弘智能机械有限公司 | It is a kind of to alleviate medicinal liquor of headache and dizzy and preparation method thereof |
| CN114712457A (en) * | 2022-04-15 | 2022-07-08 | 广东省皮发毛医学研究中心 | Chinese medicinal composition for treating hair diseases and preparation method thereof |
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Application publication date: 20161116 |