CN105055818A - Pharmaceutical preparation for treating neurodermatitis - Google Patents
Pharmaceutical preparation for treating neurodermatitis Download PDFInfo
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- CN105055818A CN105055818A CN201510557996.0A CN201510557996A CN105055818A CN 105055818 A CN105055818 A CN 105055818A CN 201510557996 A CN201510557996 A CN 201510557996A CN 105055818 A CN105055818 A CN 105055818A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and in particular provides a pharmaceutical preparation for treating neurodermatitis. The pharmaceutical preparation is prepared from the following raw materials: 25 parts of herb of Japanese St. John's wort, 18 parts of creeping rostellularia herb, 20 parts of spearmint, 25 parts of root of Chinese atropanthe, 18 parts of belveder fruit, 25 parts of fineleaf schizonepeta herb, 15 parts of Chinese angelica, 20 parts of lightyellow sophora root, 20 parts of densefruit pittany root-bark, 25 parts of root of kaempfer dutchmanspipe, 25 parts of bark of Chinese corktree, 20 parts of common anemarrhena rhizome, 15 parts of great burdock achene, 18 parts of rehmannia root, 15 parts of baical skullcap root, 18 parts of largehead atractylodes rhizome, 10 parts of white peony root and 5 parts of licorice root. The pharmaceutical preparation can be used for treating the neurodermatitis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of neurodermatitis and its preparation method and application.
Background technology
Neurodermatitis is also known as lichen chronicus simplex.It is the chronic dermatosis turning to feature with paroxysmal skin pruritus and skin lichen.For common skin diseases, be more common in adult, child does not generally fall ill.Only have scratchiness during primary disease onset, and without former skin lesion, owing to scratching and rubbing, skin engenders the flat pimple of foxtail millet grain to Semen phaseoli radiati size, circular or polygon, heavily fortified point is hard and shiny, and in pale red or normal color of the leather, is dispersed in distribution.Because there being paroxysmal play to itch, patient often scratches, and pimple increases gradually, with the passing of time then merges in flakes, plump, lichenification, shows as that dermatoglyph is deepened, cutaneous ridge protuberance, and skin lesion becomes crineous, dry, have desquamation in small, broken bits.Patch sample skin lesion clear border, can there be little flat pimple at edge, is dispersed in and isolates.The number of skin lesion patch is indefinite, can single-shot or general the whole body, and differ in size, shape differs.Be apt to occur in cervical region both sides, napex, fossa cubitalis, popliteal nest, sacrococcygeal region, wrist, ankle, also see the positions such as lower back, eyelid, extremity and pudendum.Skin lesion is only limitted to a place or a few place is local neurodermatitis; If skin lesion is widely distributed, even general, in whole body person, is called generalized neurodermatitis.For this reason, be bursting to and develop the needs that more medicines for the treatment of neurodermatitis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of neurodermatitis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of neurodermatitis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Hyperici Japonici 25 parts, Herba Rostellulariae 18 parts, Mentha spicata L. 20 parts, Neocheiropteris palmatopedata (Baker) Christ 25 parts, the Fructus Kochiae 18 parts, Herba Schizonepetae 25 parts, Radix Angelicae Sinensis 15 parts, Radix Sophorae Flavescentis 20 parts, Cortex Dictamni 20 parts, Zhu Shalian 25 parts, Cortex Phellodendri 25 parts, the Rhizoma Anemarrhenae 20 parts, Fructus Arctii 15 parts, Radix Rehmanniae 18 parts, Radix Scutellariae 15 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, the Radix Paeoniae Alba 10 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of neurodermatitis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of neurodermatitis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment neurodermatitis medicine being used for the treatment of neurodermatitis.
Herba Hyperici Japonici is the herb of Garcinia maingayii Herba Hyperici Japonici HypericumjaponicumThunb..Summer and autumn gathers.Dry.Raw use.Nature and flavor with return through: bitter in the mouth, flat.Return liver, gallbladder meridian, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For hepatitis, early stage liver cirrhosis, appendicitis, eye conjunctivitis, tonsillitis; Furuncle toxic swelling is controlled in external, herpes zoster, venom, traumatic injury.
Herba Rostellulariae (Classification system: Rostellulariaprocumbens (L.) Nees) annual draft of crawling, leaf is to life; Avette, oblong or wide lanceolar, spike top is raw or axil is raw, corolla pale red or band aubergine, and filigree base portion and attachment region surrounding have fine hair, style is thread, stigma head, capsule is linear, the short point of tip, base portion is ashamed narrow, all in flattening shape, light brown, upper surface has white pubescence.Seed oval and micro-flat, pitchy, it is protruding that surface has netted stricture of vagina.8 ~ November of florescence.: heat-clearing and toxic substances removing, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.For cold, fever, malaria, laryngopharynx swelling and pain, infantile malnutrition, dysentery, enteritis, oedema due to nephritis, urinary system infection, chyluria; External is controlled carbuncle furuncle and is swollen, traumatic injury.
Mentha spicata L., Latin is called Menthaspicata, perennial herb, and height about 1.3 meters, has branch.Rhizome spreads, and stem is square, in purple or bottle green.Dispelling wind, regulates the flow of vital energy, pain relieving.Cure cold, cough, headache, abdominal distention, dysmenorrhea.The present invention is with all herbal medicine.
Neocheiropteris palmatopedata (Baker) Christ is fern Polypodiaceae Neocheiropteris palmatopedata(Bak.) Christ platymiscium Neocheiropteris palmatopedata(Bak.) Christ Neocheiropterispalmatopedata (Baker) Christ, is used as medicine with root stock.Clearing away heat-damp and promoting diuresis, regulating the flow of QI to relieve constipation.For chronic gastritis, pipe abdomen fullness, constipation, dysentery, cystitis, pharyngitis, Fengshi Guanjie pain.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks that the erythra of neurodermatitis is with drying, coarse, plump, desquamation, pruritus is feature, morbidity and wind, dry, blood deficiency, blood stasis relation is the closest, treatment is also to search wind, moisturize, nourish blood, blood circulation promoting and blood stasis dispelling is for controlling, Herba Hyperici Japonici of the present invention, Herba Rostellulariae, Mentha spicata L., Neocheiropteris palmatopedata (Baker) Christ, the Fructus Kochiae, Herba Schizonepetae, Radix Rehmanniae, Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae, heat clearing white peony dampness removing, search wind, moisturize, nourish blood as monarch drug, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Cortex Dictamni, Zhu Shalian, Cortex Phellodendri, the Rhizoma Anemarrhenae, Fructus Arctii nourishes blood, invigorate blood circulation as ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, clearing away heat and expelling wind, blood circulation promoting and blood stasis dispelling, treatment neurodermatitis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Hyperici Japonici 25g, Herba Rostellulariae 18g, Mentha spicata L. 20g, Neocheiropteris palmatopedata (Baker) Christ 25g, Fructus Kochiae 18g, Herba Schizonepetae 25g, Radix Angelicae Sinensis 15g, Radix Sophorae Flavescentis 20g, Cortex Dictamni 20g, Zhu Shalian 25g, Cortex Phellodendri 25g, Rhizoma Anemarrhenae 20g, Fructus Arctii 15g, Radix Rehmanniae 18g, Radix Scutellariae 15g, Rhizoma Atractylodis Macrocephalae 18g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Hyperici Japonici 25g, Herba Rostellulariae 18g, Mentha spicata L. 20g, Neocheiropteris palmatopedata (Baker) Christ 25g, Fructus Kochiae 18g, Herba Schizonepetae 25g, Radix Angelicae Sinensis 15g, Radix Sophorae Flavescentis 20g, Cortex Dictamni 20g, Zhu Shalian 25g, Cortex Phellodendri 25g, Rhizoma Anemarrhenae 20g, Fructus Arctii 15g, Radix Rehmanniae 18g, Radix Scutellariae 15g, Rhizoma Atractylodis Macrocephalae 18g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba Hyperici Japonici 25g, Herba Rostellulariae 18g, Mentha spicata L. 20g, Neocheiropteris palmatopedata (Baker) Christ 25g, Fructus Kochiae 18g, Herba Schizonepetae 25g, Radix Angelicae Sinensis 15g, Radix Sophorae Flavescentis 20g, Cortex Dictamni 20g, Zhu Shalian 25g, Cortex Phellodendri 25g, Rhizoma Anemarrhenae 20g, Fructus Arctii 15g, Radix Rehmanniae 18g, Radix Scutellariae 15g, Rhizoma Atractylodis Macrocephalae 18g, Radix Paeoniae Alba 10g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment neurodermatitis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation neurodermatitis 80 cases, wherein man 40 example, female 40 example, 25 ~ 54 years old age.The shortest person of the course of disease 5 months, most elder reaches 3 years.
4.2 diagnostic criterias: the diagnosis all meeting related neurological dermatitis in " clinical dermatology ".Its clinical manifestation mainly become with skin lichen sample and violent pruritus into feature.Mostly occur at nape or its both sides, the fossa cubitalis, rouge nest, forearm, thigh, shank and lumbosacral region etc.Subjective symptoms is often the violent pruritus of paroxysmal, and night is very, and most of patients has dizziness, insomnia, irritable, the neurasthenic symptom such as anxious.
Exclusion standard: 1. skin lesion merges antibacterial or fungal infections; 2. gestation or women breast-feeding their children; 3. in selected first 1 week, glucocorticoid medicine was used in local, or took Loratadine person; 4. in 1 month, system applied glucocorticoid medicine person; 5. known to research medicine and matrix components allergy sufferers thereof; 6. Chronic Liver, kidney diaseases or other severe illness person is had; 7. diabetes or sever immune hypofunction person is had.96 routine patients all meet above-mentioned inclusive criteria.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: with reference to " new Chinese medicine guideline of clinical investigations " with skin lesion scope, form and pruritus scores accumulated, calculate curative effect rate and carry out efficacy determination.
Curative effect rate=[before (treat front integration one and treat rear integration)/treatment integration] × 100% calculates.
Clinical recovery: skin lesion all disappears, scratchiness disappears, and curative effect rate reaches 100%; Effective: skin lesion disappears more than 70%, and gargalesthesia obviously alleviates, curative effect rate reaches more than 70%; Effective: skin lesion portion disappears more than 30%, and scratchiness alleviates, curative effect rate reaches more than 30%; Invalid: skin lesion disappears less than 30%, although or skin lesion alleviate more but still constantly have new skin lesion to occur, curative effect rate does not reach 30%.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 40 | 15 | 13 | 9 | 3 | 92.5 |
| Blank group | 40 | 1 | 2 | 1 | 36 | 10 |
Visible, the medicine that the present invention obtains can safe and effective treatment neurodermatitis, and has no side effect.
4.6 Lee, female, 38 years old, suffers from neurodermatitis 2 years, position at necked elbow nest, rouge nest, forearm, thigh, shank and lumbosacral region place, the violent pruritus of paroxysmal, night is very, gives the Chinese medicine that granule embodiment of the present invention provides, after 2 courses for the treatment of, skin lesion all disappears, and scratchiness disappears.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of neurodermatitis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Hyperici Japonici 25 parts, Herba Rostellulariae 18 parts, Mentha spicata L. 20 parts, Neocheiropteris palmatopedata (Baker) Christ 25 parts, the Fructus Kochiae 18 parts, Herba Schizonepetae 25 parts, Radix Angelicae Sinensis 15 parts, Radix Sophorae Flavescentis 20 parts, Cortex Dictamni 20 parts, Zhu Shalian 25 parts, Cortex Phellodendri 25 parts, the Rhizoma Anemarrhenae 20 parts, Fructus Arctii 15 parts, Radix Rehmanniae 18 parts, Radix Scutellariae 15 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, the Radix Paeoniae Alba 10 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of neurodermatitis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of neurodermatitis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment neurodermatitis medicine of neurodermatitis according to claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770635A (en) * | 2016-04-20 | 2016-07-20 | 陈程辉 | Medicine for treating neurodermatitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172674A (en) * | 1997-08-29 | 1998-02-11 | 刘进成 | Chinese medicinal herb composition for treating skin disease |
| CN102366529A (en) * | 2011-09-28 | 2012-03-07 | 邓华伦 | Traditional Chinese medicine for treating neurodermatitis |
| CN102688371A (en) * | 2012-06-06 | 2012-09-26 | 李承平 | Tablet for dispelling wind, nourishing blood, clearing heat and removing dampness |
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2015
- 2015-09-05 CN CN201510557996.0A patent/CN105055818A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172674A (en) * | 1997-08-29 | 1998-02-11 | 刘进成 | Chinese medicinal herb composition for treating skin disease |
| CN102366529A (en) * | 2011-09-28 | 2012-03-07 | 邓华伦 | Traditional Chinese medicine for treating neurodermatitis |
| CN102688371A (en) * | 2012-06-06 | 2012-09-26 | 李承平 | Tablet for dispelling wind, nourishing blood, clearing heat and removing dampness |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770635A (en) * | 2016-04-20 | 2016-07-20 | 陈程辉 | Medicine for treating neurodermatitis |
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