CN102327390A - Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills - Google Patents
Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills Download PDFInfo
- Publication number
- CN102327390A CN102327390A CN201110314905A CN201110314905A CN102327390A CN 102327390 A CN102327390 A CN 102327390A CN 201110314905 A CN201110314905 A CN 201110314905A CN 201110314905 A CN201110314905 A CN 201110314905A CN 102327390 A CN102327390 A CN 102327390A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- root
- preparation
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006187 pill Substances 0.000 title claims abstract description 18
- 231100000331 toxic Toxicity 0.000 title claims abstract description 14
- 230000002588 toxic effect Effects 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 title abstract description 12
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 230000000973 chemotherapeutic effect Effects 0.000 title abstract 3
- 238000007086 side reaction Methods 0.000 title abstract 3
- 235000014101 wine Nutrition 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 16
- 239000003292 glue Substances 0.000 claims abstract description 14
- 241000222336 Ganoderma Species 0.000 claims abstract description 13
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 13
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 13
- 235000008434 ginseng Nutrition 0.000 claims abstract description 13
- 241000005787 Cistanche Species 0.000 claims abstract description 12
- 238000005303 weighing Methods 0.000 claims abstract description 12
- 241000241550 Cyathula Species 0.000 claims abstract description 6
- 241000209020 Cornus Species 0.000 claims description 24
- 238000002512 chemotherapy Methods 0.000 claims description 21
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 15
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 13
- 241000965254 Apostichopus japonicus Species 0.000 claims description 12
- 108010052008 colla corii asini Proteins 0.000 claims description 12
- 241001550206 Colla Species 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- 210000000582 semen Anatomy 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000009636 Huang Qi Substances 0.000 claims description 8
- 239000012567 medical material Substances 0.000 claims description 6
- 241000545442 Radix Species 0.000 claims description 5
- 241000208340 Araliaceae Species 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 241001508464 Orobanche Species 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 5
- 241000251511 Holothuroidea Species 0.000 abstract description 3
- 235000006533 astragalus Nutrition 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract description 2
- 235000008599 Poria cocos Nutrition 0.000 abstract description 2
- 235000017524 noni Nutrition 0.000 abstract description 2
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241001061264 Astragalus Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 240000007371 Cuscuta campestris Species 0.000 abstract 1
- 241000402754 Erythranthe moschata Species 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 241000212322 Levisticum officinale Species 0.000 abstract 1
- 235000017784 Mespilus germanica Nutrition 0.000 abstract 1
- 244000182216 Mimusops elengi Species 0.000 abstract 1
- 235000000560 Mimusops elengi Nutrition 0.000 abstract 1
- 244000131360 Morinda citrifolia Species 0.000 abstract 1
- 235000008898 Morinda citrifolia Nutrition 0.000 abstract 1
- 235000008248 Morinda citrifolia var citrifolia Nutrition 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 235000007837 Vangueria infausta Nutrition 0.000 abstract 1
- 210000003056 antler Anatomy 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 239000001645 levisticum officinale Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 210000004233 talus Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 27
- 239000000796 flavoring agent Substances 0.000 description 26
- 235000019634 flavors Nutrition 0.000 description 26
- 210000003734 kidney Anatomy 0.000 description 25
- 210000004369 blood Anatomy 0.000 description 24
- 230000007812 deficiency Effects 0.000 description 24
- 238000009826 distribution Methods 0.000 description 24
- 230000006870 function Effects 0.000 description 24
- 210000000952 spleen Anatomy 0.000 description 22
- 208000002193 Pain Diseases 0.000 description 21
- 235000009508 confectionery Nutrition 0.000 description 20
- 210000004185 liver Anatomy 0.000 description 20
- 210000004072 lung Anatomy 0.000 description 13
- 206010011224 Cough Diseases 0.000 description 10
- 240000004371 Panax ginseng Species 0.000 description 10
- 201000001881 impotence Diseases 0.000 description 10
- 231100000419 toxicity Toxicity 0.000 description 10
- 230000001988 toxicity Effects 0.000 description 10
- 208000006820 Arthralgia Diseases 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 8
- 206010062717 Increased upper airway secretion Diseases 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 208000002173 dizziness Diseases 0.000 description 8
- 208000026435 phlegm Diseases 0.000 description 8
- 206010033557 Palpitations Diseases 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 201000000736 Amenorrhea Diseases 0.000 description 6
- 206010001928 Amenorrhoea Diseases 0.000 description 6
- 206010010774 Constipation Diseases 0.000 description 6
- 208000010228 Erectile Dysfunction Diseases 0.000 description 6
- 231100000540 amenorrhea Toxicity 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 6
- 206010000087 Abdominal pain upper Diseases 0.000 description 5
- 206010007247 Carbuncle Diseases 0.000 description 5
- 208000019255 Menstrual disease Diseases 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 5
- 208000025747 Rheumatic disease Diseases 0.000 description 5
- 206010047700 Vomiting Diseases 0.000 description 5
- 230000036528 appetite Effects 0.000 description 5
- 235000019789 appetite Nutrition 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 230000000552 rheumatic effect Effects 0.000 description 5
- 238000005728 strengthening Methods 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241000283026 Cervus elaphus Species 0.000 description 4
- 241000283007 Cervus nippon Species 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 4
- 206010021118 Hypotonia Diseases 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- 208000009205 Tinnitus Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 206010003549 asthenia Diseases 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000017561 flaccidity Diseases 0.000 description 4
- 231100000869 headache Toxicity 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 208000035861 hematochezia Diseases 0.000 description 4
- 206010022437 insomnia Diseases 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 231100000886 tinnitus Toxicity 0.000 description 4
- 206010002383 Angina Pectoris Diseases 0.000 description 3
- 241000282994 Cervidae Species 0.000 description 3
- 206010016326 Feeling cold Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 208000012886 Vertigo Diseases 0.000 description 3
- 208000031975 Yang Deficiency Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 208000006750 hematuria Diseases 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 208000021267 infertility disease Diseases 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 208000001297 phlebitis Diseases 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 231100000889 vertigo Toxicity 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 241000045403 Astragalus propinquus Species 0.000 description 2
- 206010065553 Bone marrow failure Diseases 0.000 description 2
- 229910021532 Calcite Inorganic materials 0.000 description 2
- 206010048610 Cardiotoxicity Diseases 0.000 description 2
- 244000301850 Cupressus sempervirens Species 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001278898 Glycyrrhiza inflata Species 0.000 description 2
- 206010019851 Hepatotoxicity Diseases 0.000 description 2
- 206010024264 Lethargy Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 206010059013 Nocturnal emission Diseases 0.000 description 2
- 206010034568 Peripheral coldness Diseases 0.000 description 2
- 241000222341 Polyporaceae Species 0.000 description 2
- 241000218201 Ranunculaceae Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 206010046788 Uterine haemorrhage Diseases 0.000 description 2
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 231100000259 cardiotoxicity Toxicity 0.000 description 2
- 230000007681 cardiovascular toxicity Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 230000007686 hepatotoxicity Effects 0.000 description 2
- 231100000304 hepatotoxicity Toxicity 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 208000005069 pulmonary fibrosis Diseases 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 206010042772 syncope Diseases 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 241000227129 Aconitum Species 0.000 description 1
- 241001671653 Aconitum carmichaelii Species 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 1
- 241000336316 Cistanche tubulosa Species 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 102000016918 Complement C3 Human genes 0.000 description 1
- 108010028780 Complement C3 Proteins 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 244000013539 Cuscuta australis Species 0.000 description 1
- 241000110637 Cuscuta chinensis Species 0.000 description 1
- 241000514824 Cyathula officinalis Species 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000237537 Ensis Species 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 206010060710 Galactostasis Diseases 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 241001489091 Ganoderma sinense Species 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
- 235000000554 Glycyrrhiza uralensis Nutrition 0.000 description 1
- 240000002045 Guettarda speciosa Species 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000244355 Ligusticum Species 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 241000607292 Maguireothamnus speciosus Species 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 241000157491 Morinda Species 0.000 description 1
- 241000972191 Moschus berezovskii Species 0.000 description 1
- 241000972159 Moschus chrysogaster Species 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000576755 Sclerotia Species 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 241000258191 Stichopodidae Species 0.000 description 1
- 241000960984 Stichopus chloronotus Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 210000000662 T-lymphocyte subset Anatomy 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010046792 Uterine hypotonus Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910001748 carbonate mineral Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- QVFWZNCVPCJQOP-UHFFFAOYSA-N chloralodol Chemical compound CC(O)(C)CC(C)OC(O)C(Cl)(Cl)Cl QVFWZNCVPCJQOP-UHFFFAOYSA-N 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000037306 mature skin Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000018299 prostration Diseases 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019991 rice wine Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a formula of a Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and a preparation method for Chinese medicinal pills. The Chinese medicine consists of donkey-hide gelatin, ginseng, cassia bark, Szechuan lovage rhizome, prepared rehmannia root, tuckahoe, largehead atractylodes rhizome, astragalus, Chinese angelica, white paeony root, south dodder seed, medlar, medicinal cyathula root, tangerine peel, glossy ganoderma, desertliving cistanche, hairy antler, musk, stalactite, medicinal indianmulberry root, prepared common monkshood daughter root, sea cucumber, liquoric root, deerhorn glue and yellow wine in a certain weight ratio. The preparation method comprises the following steps of: weighing the deerhorn glue in the weight ratio, adding into the yellow wine in the weight ratio, decocting, and cooling to room temperature to obtain glue solution; weighing the rest medicinal materials in the weight ratio, mixing uniformly, and crushing to form medicinal powder; and adding the medicinal powder into the glue solution, mixing uniformly, and pelletizing to form pills, wherein each pill is 5 grams. Clinical tests prove that the Chinese medicine can prevent and treat chemotherapeutic toxic and side reaction safely and effectively; and the preparation method for the pills is simple, convenient, easy and environment-friendly, and is suitable for production and clinical application.
Description
Technical field
The present invention relates to a kind of method for preparing of preventing and treating the Chinese prescription and the pill thereof of chemotherapy toxic side effect.
Background technology
Chemotherapy is present tumor, especially malignant tumor, a kind of therapeutic modality that the patient the most extensively adopts.Its principle is: utilize the differentiation of the growth and breeding and the promotion tumor cell of chemicals kill tumor cell, inhibition tumor cell.But have more the more serious toxicity of existing lethargy, immunologic function degression, bone marrow depression, nausea and vomiting, dizziness headache, Toxicity of Kidney, phlebitis, hepatotoxicity or the like in the therapeutic process, very big to human harm.
Existing oncotherapy protection preparation can not solve the toxicity of chemotherapy to human body well, to such an extent as to a lot of tumor patient is in heaven in the toxicity of chemotherapy in therapeutic process.
The present Research of medical material involved in the present invention is following:
Colla Corii Asini: [source] these article for the dry skin of equine species donkey Equus asinus L. or Cortex Dictamni through decocting, concentrate the solid gum of processing.[meridian distribution of property and flavor] is sweet, and be flat.Return lung, liver, kidney channel.[function cures mainly] YIN nourishing of enriching blood is moisturized, hemostasis.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, the flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, chronic cough spitting of blood, haematemesis hematuria, the metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Radix Ginseng: [source] these article are dry root and the rhizome of Araliaceae Radix Ginseng Panax ginseng C.A. Mey..[meridian distribution of property and flavor] sweet, little hardship, tepor.Return spleen, lung, the heart, kidney channel.[function cures mainly] strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid and nourishes blood, the Fructus Alpiniae Oxyphyllae of calming the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness is empty wins, the palpitation with fear insomnia, sexual impotence official is cold.
Cortex Cinnamomi: [source] these article are the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.[meridian distribution of property and flavor] is hot, sweet, big heat.Return kidney, spleen, the heart, Liver Channel.It is supporing yang that [function cures mainly] mended fire, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian.Be used for the sexual impotence cold womb, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily, upward floating of YANG in deficiency condition, and dizzy conjunctival congestion, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type stomachache, dysmenorrhea amenorrhea.
Rhizoma Chuanxiong: [source] these article are the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuam.iong Hort..[meridian distribution of property and flavor] suffering, temperature.Return liver, gallbladder, pericardium channel.[function cures mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for obstruction of qi in the chest and cardialgia, the twinge of the breast side of body, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea, addiction abdominal mass stomachache, headache, rheumatic arthralgia.
Radix Rehmanniae Preparata: [source] these article are the process of preparing Chinese medicine processed goods of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch. tuber.[meridian distribution of property and flavor] is sweet, tepor.Return liver, kidney channel.[function cures mainly] YIN nourishing of enriching blood, beneficial essence is filled out marrow.Be used for blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, and is dizzy, tinnitus, chin is sent out early white.
Poria: [source] these article are the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf.[meridian distribution of property and flavor] is sweet, light, and be flat.GUIXIN, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
The Rhizoma Atractylodis Macrocephalae: [source] these article are the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atract μ lodes macrocephala Koidz..[meridian distribution of property and flavor] is bitter, sweet, temperature.Return spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
The Radix Astragali: [source] these article are the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch) Bge.var.mongholicus (Bge) Hsiao or Radix Astragali Astragalus membranaceus (Fisch) Bge..[meridian distribution of property and flavor] is sweet, tepor.Return lung, spleen channel.[function cures mainly] tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, arthralgia pain is numb, and carbuncle is difficult bursts, and bursts for a long time and does not hold back.
Radix Angelicae Sinensis: [source] is the dry root of umbelliferae angelica Angelica sin:ensis (Oliv.) Diels.[meridian distribution of property and flavor] is sweet, hot, temperature.Return liver, the heart, spleen channel.[function cures mainly] blood is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
The Radix Paeoniae Alba: [source] these article are the dry root of ranunculaceae plant Radix Paeoniae Paeonia tacti lora Pall..[meridian distribution of property and flavor] is bitter, sour, is slightly cold.Return liver, spleen channel.[function cures mainly] nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.Be used for blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, it is dizzy to have a headache.
Semen Cuscutae: [source] these article are the dry mature seed of convolvulaceous plant south Semen Cuscutae Cuscuta australis. or Semen Cuscutae Cuscuta chinensis Lam..[meridian distribution of property and flavor] is hot, sweet, and be flat.Return the liver,kidney,spleen warp.[function cures mainly] liver and kidney tonifying, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal; External pathogenic wind expelling speckle dispelling.Be used for deficiency of the liver and kindey, soreness of the waist and knees, impotence and seminal emission, enuresis frequent micturition.Vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, blurred vision tinnitus, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Fructus Lycii: [source] these article are the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..[meridian distribution of property and flavor] is sweet, and be flat.Return liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Radix Cyathulae: [source] these article are the dry root of amaranthaceous plant Radix Cyathulae Cyathula officinalis Kuan.[meridian distribution of property and flavor] sweet, little hardship, flat.Return liver, kidney channel.[function cures mainly] eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.Be used for the lame abdominal mass of amenorrhea, retention of placenta, injury from falling down, rheumatic arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood.
Pericarpium Citri Reticulatae: [source] these article are the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.[meridian distribution of property and flavor] is bitter, hot, temperature.Return lung, spleen channel.[function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Ganoderma: [source] these article are Polyporaceae fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. Gan.The dry sporophore of derma lucidum (Ley-ss.ex Fr.) Karst. or Ganoderma Ganoderma sinense ZhaoXuetZhang.[meridian distribution of property and flavor] is sweet, and be flat.GUIXIN, lung, liver, kidney channel.[function cures mainly] invigorating QI and tranquilization, relieving cough and asthma.Be used for malaise, insomnia cardiopalmus, cough and asthma due to lung deficiency, asthenia is losed heart, anorexia.
Herba Cistanches: [source] these article are the chylocaulous of the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticolaY.C.Ma or Cistanche Tubulosa Cistan.che tubulosa (Schrenk) Wight.[meridian distribution of property and flavor] is sweet, salty, temperature.Return kidney, large intestine channel.[function cures mainly] kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Be used for insufficiency of kidney-YANG, essence and blood loses empty, and sexual impotence is infertile, soreness of the waist and knees, and muscles and bones is unable, the dryness of the intestine constipation.
Cornu Cervi Pantotrichum: [source] these article are the young horn of the unossified close living fine hair of stag of animal in deer family Cervus nippon Temminck cervus nippon Temminck or Cervus elaphus linnaeus cervus elaphus Linnaeus.[meridian distribution of property and flavor] is sweet, salty, temperature.Return kidney, Liver Channel.[function cures mainly] invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening is transferred to dash and is appointed, the holder sore.Be used for insufficiency of kidney-YANG, essence and blood loses empty, the sexual impotence spermatorrhea, cold womb is infertile, win thin, Mental fatigue, fear of cold, dizzy, tinnitus, deafness, the spinal column cold type of pain, the muscles and bones flaccidity is soft, bleeding not during menses, carbuncle of yin nature is not held back.
Moschus: [source] these article are the dry secretions in the ripe male body note capsule of animal in deer family woods Moschus moschiferous Moschus berezovskii Flerov, horse Moschus moschiferous Moschus sifanicus Przewalski or former Moschus moschiferous Moschus mlschiferus Linnaeus.[meridian distribution of property and flavor] suffering, temperature.GUIXIN, spleen channel.[function cures mainly] refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Be used for the calentura coma, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, amenorrhea ， mass in the abdomen, the difficult labour stillborn fetus, obstruction of qi in the chest and cardialgia, trusted subordinate's sudden pain falls and pounces on the pain of injury, and arthralgia pain is numb, carbuncle scrofula, laryngopharynx swelling and pain.[usage and dosage] 0.03～0.1g
Stalactitum: [source] these article are carbonate mineral calcite family calcite, main carbonated calcium (CaCO
3).After excavating, remove roguing stone.[meridian distribution of property and flavor] is sweet, temperature.Return lung, kidney, stomach warp.[function cures mainly] warming the lung, supporing yang, relieving asthma antacid, lactogenesis.Be used for the cold-phlegm cough with asthma, yang deficiency is cold breathes heavily, chills and pain of the waist and kness, stomachache pantothenic acid, galactostasis.
Radix Morindae Officinalis: [source] these article are Maguireothamnus speciosus Radix Morindae Officinalis Morinda ojj:icinalis How sunlight dry root.[meridian distribution of property and flavor] is sweet, hot, tepor.Return kidney, Liver Channel.[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, the muscles and bones flaccidity is soft.
Radix Aconiti Lateralis Preparata: [source] these article are the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaelii Debx.[meridian distribution of property and flavor] is hot, sweet, big heat; Poisonous.GUIXIN, kidney, spleen channel.[function cures mainly] recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, dispersing cold for relieving pain.Be used for the YANG-depletion collapse, the cold extremities faint pulse, deficiency of heart-YANG, obstruction of qi in the chest and cardialgia, deficiency and coldness is vomited and diarrhoea, coldness and pain in the epigastrium, kidney yang deficiency, sexual impotence cold womb, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
Stichopus japonicus: [source] Echinodermata Holothuroidea Stichopodidae animal Radix Morinae Bulleyanae, Stichopus chloronotus (Brandt)., change Radix Morinae Bulleyanae all.[meridian distribution of property and flavor] sweet in the mouth; Salty; Property is put down.The loss of [function cures mainly] essence and blood; Weak labor is timid; Sexual impotence; Nocturnal emission; The dryness of the intestine constipation; Cough due to deficiency of the lung's spitting of blood, discharging fresh blood stool, traumatic hemorrhage.[usage and dosage] 9-30g.
Radix Glycyrrhizae: [source] is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[meridian distribution of property and flavor] is sweet, and be flat.GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Colla cornus cervi: [source] these article boil, concentrate the solid gum of processing for the angle base that the ossified angle of animal in deer family Cervus elaphus linnaeus Cervus elaphus Linnaeus or Cervus nippon Temminck Cervus nippon Temminck or the fine and soft back of saw come off spring in next year through decocting.[meridian distribution of property and flavor] is sweet, salty, temperature.Return kidney, Liver Channel.[function cures mainly] temperature compensation Liver and kidney, beneficial intensive culture blood.The waist knee joint acid that is used for due to the deficiency of the liver and kindey is cold, impotence and seminal emission, and asthenia is won thin, metrostaxis, the hematuria of having blood in stool, carbuncle of yin nature swells and ache.
Yellow wine: yellow wine is one of the most ancient in the world drinks, comes from China.Yellow wine is to be raw material with grain, leads to through combineds effect such as distillers yeast and yeast for brewing rice wine, and its main component is an ethanol, and concentration is generally 8%-20%, belongs to low brewed wine.Protein content in the yellow wine be in the wine, how to exist with peptide and amino acid whose form, be prone to be absorbed by the body.Can be used as guiding drug, the fat-soluble medicine composition is better absorbed by body.
Summary of the invention
The present invention aims to provide a kind of method for preparing of preventing and treating the Chinese prescription and the pill thereof of chemotherapy toxic side effect; Through selecting suitable medicine and proportioning thereof and formulating the method for preparing of its pill, the purpose that reaches safe and effective control chemotherapy toxic side effect and make it be suitable for applying clinically.
In order to achieve the above object, the present invention adopts following technical scheme:
A kind of Chinese prescription of preventing and treating chemotherapy toxic side effect; It is characterized in that it is made up of the medical material of following weight proportion: Colla Corii Asini 20-40 part, Radix Ginseng 20-40 part, Cortex Cinnamomi 20-40 part, Rhizoma Chuanxiong 20-40 part, Radix Rehmanniae Preparata 10-20 part, Poria 20-40 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Radix Astragali 20-40 part, Radix Angelicae Sinensis 20-40 part, Radix Paeoniae Alba 20-40 part, Semen Cuscutae 20-40 part, Fructus Lycii 20-40 part, Radix Cyathulae 20-40 part, Pericarpium Citri Reticulatae 20-40 part, Ganoderma 20-40 part, Herba Cistanches 20-40 part, Cornu Cervi Pantotrichum 20-40 part, Moschus 2-4 part, Stalactitum 5-15 part, Radix Morindae Officinalis 5-15 part, Radix Aconiti Lateralis Preparata 5-15 part, Stichopus japonicus 5-15 part, Radix Glycyrrhizae 20-40 part, Colla cornus cervi 100-200 part, yellow wine 300-500 part.
Wherein the optimum weight proportioning of each medical material is: 30 parts in Colla Corii Asini, 30 parts of Radix Ginsengs, 30 parts of Cortex Cinnamomis, 30 parts of Rhizoma Chuanxiongs, 15 parts of Radix Rehmanniae Preparata, 30 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of the Radixs Astragali, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Semen Cuscutae, 30 parts of Fructus Lycii, 30 parts of Radix Cyathulaes, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Ganodermas, 30 parts of Herba Cistanches, 30 parts in Cornu Cervi Pantotrichum, 3 parts in Moschus, 10 parts of Stalactitums, 10 parts of Radix Morindae Officinaliss, 10 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Stichopus japonicuss, 30 parts in Radix Glycyrrhizae, 150 parts of Colla cornus cervis, 400 parts of yellow wine.
The technology that Chinese prescription of the present invention is prepared into pill is: the Colla cornus cervi that takes by weighing said weight portion joins in the yellow wine of said weight portion and endures out, and is cooled to room temperature, glue; Take by weighing Colla Corii Asini, Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Pericarpium Citri Reticulatae, Ganoderma, Herba Orobanches, Cornu Cervi Pantotrichum, Moschus, clock milk powder, crust halberd, Radix Aconiti Lateralis Preparata, Stichopus japonicus, the Radix Glycyrrhizae mix homogeneously of said weight portion, be ground into medicated powder; Above-mentioned medicated powder is joined in the above-mentioned glue, and mix homogeneously is divided into 5 gram/parts, and ball is processed by group, promptly gets.Said medicated powder preferably is ground into 100 orders.
Usage and dosage: oral, normal adult 2 times on the one, one time 1 ball.
The beneficial effect that we are bright:
Colla Corii Asini in the prescription of the present invention, Radix Ginseng, Cortex Cinnamomi, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Ganoderma, Herba Cistanches, Cornu Cervi Pantotrichum, crust halberd, Radix Aconiti Lateralis Preparata, Stichopus japonicus, Cornu Cervi can warm the five internal organs, benefit lean blood, help to rebuild one's physical constitution; Rhizoma Chuanxiong, Poria, Pericarpium Citri Reticulatae, Moschus, Stalactitum can sensiblely be regulated the flow of vital energy, blood-activating analgetic, battalion are defended negative and positive; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription; Yellow wine is for drawing.To all diseases of the deficiency of both QI and blood that occurs after the chemotherapy, can lead to the five internal organs, awake key order, element culturing fixed folder, improve body immunity, resist the huge injury that chemotherapy causes.
Clinical trial confirms that prescription of the present invention can be prevented and treated chemotherapy toxic side effect safely and effectively; Find out that easily simple and easy to do, the environmental protection of the method for preparing of pill of the present invention is fit to produce and clinical practice.
The beneficial effect of prescription of the present invention is described below in conjunction with clinical testing data:
From year February in February, 2008 to 2011; Institute of traditional Chinese medicine uses the present invention's pill treatment chemotherapy of tumors patient 75 examples that best prescription makes of writing out a prescription to the inventor in Laizhou City; And orally rise cypress and carry out controlled observation with flavor holothurian oral liquid treatment chemotherapy side effect 30 examples with using the same period, receive better effects.
1, clinical data
Physical data is observed case totally 105 examples, is divided into 2 groups at random.75 examples are organized in treatment, male 30 examples, women 45 examples; Year at age (39.5 ± 15.27); The course of disease (2 ± 1) year; Matched group 30 examples, male 20 examples, women 10 examples; Year at age (39.0 ± 15.4); The course of disease (2 ± 1) year.Two groups of physical data are through statistical procedures, and there are no significant that meaning (P＞0.05) has comparability for difference.
2, Therapeutic Method
Matched group adopts oral the liter cypress and flavor holothurian oral liquid, every day 2 times, each 1 bottle, 5 weeks of the course of treatment; The pill that the treatment group adopts the best prescription of oral the present invention to make, every day 2 times, each 1 ball, 5 weeks of the course of treatment.
3, observational technique:
3.1 clinical efficacy: following all situation change before and after comprising treatment:
1) health is weak: whole body fatigue and weak, lethargy, cold perspiration, drowsiness can appear in the patient.
2) immunologic function degression: immunologic function index such as the test of E-rosette, CH50, C3 complement, T cell subsets, NK cytoactive, interleukin I I.
3) bone marrow depression: leukocyte and platelet descend, degradation under erythrocyte, the hematochrome.
4) gastricism: appetite descends, dietary amount reduces, feel sick, vomiting, abdominal distention, stomachache, diarrhoea or constipation.
5) inflammatory reaction: heating, dizziness, headache, xerostomia, aphtha of the mouth and tongue.
6) cardiac toxicity: cardiac toxicity, the infringement myocardial cell, having palpitation appears in the patient, cardiopalmus, uncomfortable in chest, symptom such as pareordia is uncomfortable, breathe hard, even heart failure occurs.Electrocardioscopy T ripple changes or the S-T section changes.
7) Toxicity of Kidney: renal function injury such as lumbago, kidney district discomfort.
8) pulmonary fibrosis: pulmonary fibrosis, clap the visible increased bronchovascular shadows of rabat or be streak change.
9. phlebitis: phlebitis in various degree, the blood vessel color of pathological changes becomes kermesinus or dark yellow, local pain, being of touching is streak.
10) nervous system toxicity: acroanesthesia, acra is insensitive.
11) hepatotoxicity: abnormal liver function, uncomfortable liver area.
12) cystitis.
3.2 criterion of therapeutical effect is with reference to relevant criterion of therapeutical effect in " disease of tcm judgement criterion of therapeutical effect ".Recovery from illness: clinical symptoms all disappears, and the test chamber inspection is normal.Take a turn for the better: clinical symptom relief, lab testing improve or are normal.Invalid: clinical symptoms does not have being clearly better or increases the weight of.
3.3 statistical method adopts the SPSS statistical software to analyze.
4, therapeutic outcome
Two groups of clinical efficacies are relatively seen table 1.Total effective rate treatment group is that 87.9% matched group is 76.6%, two group of comparison, and difference has significance meaning (P＜0.05).
Table 1 liang group clinical efficacy relatively
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| The treatment group | 75 | 13(17.3%) | 53(70.6%) | 9(12%) | 87.9% |
| Matched group | 30 | 2(6.6%) | 21(70%) | 7(23.3%) | 76.6% |
With preceding relatively ※ P＜0.01 of treatment; With comparison △ P＜0.01 after the treatment of control group
It is thus clear that the medicine that optimum weight proportioning prescription of the present invention makes is respond well for the control chemotherapy toxic side effect.
According to above-mentioned clinical experiment data; In conjunction with prescription mechanism of the present invention and general knowledge known in this field; Those skilled in the art know by inference easily; Medical material among utilization the present invention; Get near the value of its optimum weight proportioning; Be Colla Corii Asini 20-40 part, Radix Ginseng 20-40 part, Cortex Cinnamomi 20-40 part, Rhizoma Chuanxiong 20-40 part, Radix Rehmanniae Preparata 10-20 part, Poria 20-40 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Radix Astragali 20-40 part, Radix Angelicae Sinensis 20-40 part, Radix Paeoniae Alba 20-40 part, Semen Cuscutae 20-40 part, Fructus Lycii 20-40 part, Radix Cyathulae 20-40 part, Pericarpium Citri Reticulatae 20-40 part, Ganoderma 20-40 part, Herba Cistanches 20-40 part, Cornu Cervi Pantotrichum 20-40 part, Moschus 2-4 part, Stalactitum 5-15 part, Radix Morindae Officinalis 5-15 part, Radix Aconiti Lateralis Preparata 5-15 part, Stichopus japonicus 5-15 part, Radix Glycyrrhizae 20-40 part, Colla cornus cervi 100-200 part, yellow wine 300-500 part, also can obtain the medicine similar techniques effect that makes with optimum weight proportioning prescription of the present invention.
The specific embodiment
In order to understand better and embodiment of the present invention, further specify the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take by weighing 150 parts of Colla cornus cervis and join in 400 parts the yellow wine and endure out, be cooled to room temperature, glue; Take by weighing 30 parts in Colla Corii Asini, 30 parts of Radix Ginsengs, 30 parts of Cortex Cinnamomis, 30 parts of Rhizoma Chuanxiongs, 15 parts of Radix Rehmanniae Preparata, 30 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of the Radixs Astragali, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Semen Cuscutae, 30 parts of Fructus Lycii, 30 parts of Radix Cyathulaes, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Ganodermas, 30 parts of Herba Cistanches, 30 parts in Cornu Cervi Pantotrichum, 3 parts in Moschus, 10 parts of Stalactitums, 10 parts of Radix Morindae Officinaliss, 10 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Stichopus japonicuss, 30 parts of mix homogeneously of Radix Glycyrrhizae, be ground into medicated powder; Above-mentioned medicated powder is joined in the above-mentioned glue, and mix homogeneously is divided into 5 gram/parts, and ball is processed by group, gets pill.
Be used to prevent and treat the toxicity that chemotherapy causes, oral, every day 2 times, one time 1 ball.
Specific embodiment 2
Take by weighing 100 parts of Colla cornus cervis and join in 300 parts the yellow wine and endure out, be cooled to room temperature, glue; Take by weighing 20 parts in Colla Corii Asini, 20 parts of Radix Ginsengs, 20 parts of Cortex Cinnamomis, 20 parts of Rhizoma Chuanxiongs, 10 parts of Radix Rehmanniae Preparata, 20 parts in Poria, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of the Radixs Astragali, 20 parts of Radix Angelicae Sinensis, 20 parts of the Radix Paeoniae Albas, 20 parts of Semen Cuscutae, 20 parts of Fructus Lycii, 20 parts of Radix Cyathulaes, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Ganodermas, 20 parts of Herba Cistanches, 20 parts in Cornu Cervi Pantotrichum, 2 parts in Moschus, 5 parts of Stalactitums, 5 parts of Radix Morindae Officinaliss, 5 parts of Radix Aconiti Lateralis Preparatas, 5 parts of Stichopus japonicuss, 20 parts of mix homogeneously of Radix Glycyrrhizae, be ground into medicated powder; Above-mentioned medicated powder is joined in the above-mentioned glue, and mix homogeneously is divided into 3 gram/parts, and ball is processed by group, gets pill.
Be used to prevent and treat the toxicity that chemotherapy causes, oral, every day 2 times, one time 1 ball.
Specific embodiment 3
Take by weighing 200 parts of Colla cornus cervis and join in 500 parts the yellow wine and endure out, be cooled to room temperature, glue; Take by weighing 40 parts in Colla Corii Asini, 40 parts of Radix Ginsengs, 40 parts of Cortex Cinnamomis, 40 parts of Rhizoma Chuanxiongs, 20 parts of Radix Rehmanniae Preparata, 40 parts in Poria, 40 parts of the Rhizoma Atractylodis Macrocephalaes, 40 parts of the Radixs Astragali, 40 parts of Radix Angelicae Sinensis, 40 parts of the Radix Paeoniae Albas, 40 parts of Semen Cuscutae, 40 parts of Fructus Lycii, 40 parts of Radix Cyathulaes, 40 parts of Pericarpium Citri Reticulataes, 40 parts of Ganodermas, 40 parts of Herba Cistanches, 40 parts in Cornu Cervi Pantotrichum, 4 parts in Moschus, 15 parts of Stalactitums, 15 parts of Radix Morindae Officinaliss, 15 parts of Radix Aconiti Lateralis Preparatas, 15 parts of Stichopus japonicuss, 40 parts of mix homogeneously of Radix Glycyrrhizae, be ground into medicated powder; Above-mentioned medicated powder is joined in the above-mentioned glue, and mix homogeneously is divided into 8 gram/parts, and ball is processed by group, gets pill.
Be used to prevent and treat the toxicity that chemotherapy causes, oral, every day 2 times, one time 1 ball.
Claims (4)
1. Chinese prescription of preventing and treating chemotherapy toxic side effect; It is characterized in that it is made up of the medical material of following weight proportion: Colla Corii Asini 20-40 part, Radix Ginseng 20-40 part, Cortex Cinnamomi 20-40 part, Rhizoma Chuanxiong 20-40 part, Radix Rehmanniae Preparata 10-20 part, Poria 20-40 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Radix Astragali 20-40 part, Radix Angelicae Sinensis 20-40 part, Radix Paeoniae Alba 20-40 part, Semen Cuscutae 20-40 part, Fructus Lycii 20-40 part, Radix Cyathulae 20-40 part, Pericarpium Citri Reticulatae 20-40 part, Ganoderma 20-40 part, Herba Cistanches 20-40 part, Cornu Cervi Pantotrichum 20-40 part, Moschus 2-4 part, Stalactitum 5-15 part, Radix Morindae Officinalis 5-15 part, Radix Aconiti Lateralis Preparata 5-15 part, Stichopus japonicus 5-15 part, Radix Glycyrrhizae 20-40 part, Colla cornus cervi 100-200 part, yellow wine 300-500 part.
2. according to the Chinese prescription of the described control chemotherapy toxic side effect of claim 1; It is characterized in that it is made up of the medical material of following weight proportion: 30 parts in Colla Corii Asini, 30 parts of Radix Ginsengs, 30 parts of Cortex Cinnamomis, 30 parts of Rhizoma Chuanxiongs, 15 parts of Radix Rehmanniae Preparata, 30 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of the Radixs Astragali, 30 parts of Radix Angelicae Sinensis, 30 parts of the Radix Paeoniae Albas, 30 parts of Semen Cuscutae, 30 parts of Fructus Lycii, 30 parts of Radix Cyathulaes, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Ganodermas, 30 parts of Herba Cistanches, 30 parts in Cornu Cervi Pantotrichum, 3 parts in Moschus, 10 parts of Stalactitums, 10 parts of Radix Morindae Officinaliss, 10 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Stichopus japonicuss, 30 parts in Radix Glycyrrhizae, 150 parts of Colla cornus cervis, 400 parts of yellow wine.
3. according to the method for preparing of the pill of the Chinese prescription of the described control chemotherapy toxic side effect of claim 2, it is characterized in that the Colla cornus cervi that takes by weighing said weight portion joins in the yellow wine of said weight portion and endures out, and is cooled to room temperature, glue; Take by weighing Colla Corii Asini, Radix Ginseng, Cortex Cinnamomi, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Semen Cuscutae, Fructus Lycii, Radix Cyathulae, Pericarpium Citri Reticulatae, Ganoderma, Herba Orobanches, Cornu Cervi Pantotrichum, Moschus, clock milk powder, crust halberd, Radix Aconiti Lateralis Preparata, Stichopus japonicus, the Radix Glycyrrhizae mix homogeneously of said weight portion, be ground into medicated powder; Above-mentioned medicated powder is joined in the above-mentioned glue, and mix homogeneously is divided into 5 gram/parts, and ball is processed by group, promptly gets.
4. according to the method for preparing of the Chinese prescription pill of the described control chemotherapy toxic side effect of claim 3, it is characterized in that said medicated powder is ground into 100 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103149052A CN102327390B (en) | 2011-10-18 | 2011-10-18 | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103149052A CN102327390B (en) | 2011-10-18 | 2011-10-18 | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102327390A true CN102327390A (en) | 2012-01-25 |
| CN102327390B CN102327390B (en) | 2012-10-31 |
Family
ID=45479522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103149052A Active CN102327390B (en) | 2011-10-18 | 2011-10-18 | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102327390B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417911A (en) * | 2013-07-10 | 2013-12-04 | 李俊萍 | Traditional Chinese medicine composition for supporting chemo-treatment |
| CN104286845A (en) * | 2014-09-17 | 2015-01-21 | 黄彩峰 | Traditional Chinese medicine medicated diet formula for postoperative nursing after chemotherapy, and preparation method thereof |
| CN104491587A (en) * | 2015-01-08 | 2015-04-08 | 李宏 | Medicament for relieving side effects of damaging liver and kidney functions due to chemotherapy and preparation method thereof |
| CN104491182A (en) * | 2015-01-08 | 2015-04-08 | 李宏 | Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method |
| CN104524300A (en) * | 2015-01-08 | 2015-04-22 | 李宏 | Medicament for improving myocardial ischemia injury caused by chemotherapy and preparation method |
| CN104606613A (en) * | 2015-01-08 | 2015-05-13 | 李宏 | Herbal cuisine for inhibiting gastrointestinal reaction of chemotherapy and preparation |
| CN104606614A (en) * | 2015-01-08 | 2015-05-13 | 李宏 | Traditional Chinese medicine composition for inhibiting gastrointestinal reaction of chemotherapy and preparation |
| CN104840874A (en) * | 2015-04-02 | 2015-08-19 | 王茂玉 | Traditional Chinese medicine pills used for aneurysm postoperative rehabilitation treatment and preparation method thereof |
| CN105106479A (en) * | 2015-10-13 | 2015-12-02 | 王俊英 | Traditional Chinese medicine for preventing and treating injury caused by extravasation of chemotherapeutic drugs and multifunctional stirring device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354014A (en) * | 2001-11-29 | 2002-06-19 | 廖干甫 | Gongbu ointment |
-
2011
- 2011-10-18 CN CN2011103149052A patent/CN102327390B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1354014A (en) * | 2001-11-29 | 2002-06-19 | 廖干甫 | Gongbu ointment |
Non-Patent Citations (2)
| Title |
|---|
| 曹廷兴等: "中药在肿瘤化疗过程中对毒副反应的缓解作用", 《中国医院药学杂志》, vol. 19, no. 8, 31 August 1999 (1999-08-31), pages 484 - 485 * |
| 王志华等: "应用中药补益剂拮抗恶性肿瘤化疗毒副反应的临床观察", 《实用全科医学》, vol. 2, no. 3, 31 March 2004 (2004-03-31), pages 254 - 255 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417911A (en) * | 2013-07-10 | 2013-12-04 | 李俊萍 | Traditional Chinese medicine composition for supporting chemo-treatment |
| CN104286845A (en) * | 2014-09-17 | 2015-01-21 | 黄彩峰 | Traditional Chinese medicine medicated diet formula for postoperative nursing after chemotherapy, and preparation method thereof |
| CN104491587A (en) * | 2015-01-08 | 2015-04-08 | 李宏 | Medicament for relieving side effects of damaging liver and kidney functions due to chemotherapy and preparation method thereof |
| CN104491182A (en) * | 2015-01-08 | 2015-04-08 | 李宏 | Traditional Chinese medicine for reducing side effects of chemotherapy and preparation method |
| CN104524300A (en) * | 2015-01-08 | 2015-04-22 | 李宏 | Medicament for improving myocardial ischemia injury caused by chemotherapy and preparation method |
| CN104606613A (en) * | 2015-01-08 | 2015-05-13 | 李宏 | Herbal cuisine for inhibiting gastrointestinal reaction of chemotherapy and preparation |
| CN104606614A (en) * | 2015-01-08 | 2015-05-13 | 李宏 | Traditional Chinese medicine composition for inhibiting gastrointestinal reaction of chemotherapy and preparation |
| CN104491587B (en) * | 2015-01-08 | 2018-01-12 | 魏仁东 | The medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy and preparation |
| CN104840874A (en) * | 2015-04-02 | 2015-08-19 | 王茂玉 | Traditional Chinese medicine pills used for aneurysm postoperative rehabilitation treatment and preparation method thereof |
| CN105106479A (en) * | 2015-10-13 | 2015-12-02 | 王俊英 | Traditional Chinese medicine for preventing and treating injury caused by extravasation of chemotherapeutic drugs and multifunctional stirring device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102327390B (en) | 2012-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102327390B (en) | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills | |
| CN102319408B (en) | Chinese medicine for strengthening spleen, eliminating dampness and treating gastroptosis and extraction method thereof | |
| CN106075276A (en) | A kind of for Chinese medicine preparation treating threatened abortion and preparation method thereof | |
| CN104352776A (en) | Traditional Chinese medicine preparation for treating infertility caused by hypomenorrhea and preparation method thereof | |
| CN102370878B (en) | Chinese medicinal oral preparation for treating aphthous stomatitis | |
| CN106511864A (en) | Traditional Chinese medicine composition and preparation method and applications thereof in treatment of cervical carcinoma | |
| CN101912551B (en) | Miscarriage-prevention Chinese medicinal composition | |
| CN102698210A (en) | Traditional Chinese medicine capable of invigorating spleen and supplementing qi and treating gastroptosis | |
| CN102552748A (en) | Traditional Chinese medicine capable of maintaining beauty and keeping young | |
| CN102657798B (en) | Compound propolis composition to increase lactation yield of livestock and preparation method thereof | |
| CN104922538A (en) | Chinese herbal preparation used for IgA nephropathy and preparing method thereof | |
| CN102078559A (en) | Chinese medicinal composition with functions of tonifying kidney and strengthening brain | |
| CN104435712A (en) | Drink granules for treating prostatic diseases | |
| CN103690875A (en) | Traditional Chinese medicinal preparation for treating aplastic anemia | |
| CN103536759B (en) | A kind of Chinese medicine for the treatment of the infertile disease of asthenia of both the spleen and kidney pattern of syndrome | |
| CN104906526A (en) | Chinese medicine preparation for premature ovarian failure and preparation method of Chinese medicine preparation | |
| CN105267630A (en) | Traditional Chinese medicine for treating tinnitus | |
| CN103536892B (en) | Traditional Chinese medicine for treating infertility of syndrome of yang deficiency and coagulated cold | |
| CN103656199B (en) | A kind of Chinese medicine for the treatment of deficiency of kidney yin syndrome cough | |
| CN102061248A (en) | Formula of vegetarian nourishing health-preserving wine | |
| CN105999019A (en) | Traditional Chinese medicine preparation for enhancing chemotherapeutic effect on breast cancer and preparation method of traditional Chinese medicine preparation | |
| CN105878901A (en) | Traditional Chinese medicine preparation for treating skin flap necrosis after breast cancer operation and preparation method | |
| CN105148164A (en) | Antai Buqi Chinese herbal medicament for livestock | |
| CN113813333A (en) | Viscera function plaster formula and preparation method thereof | |
| CN104096094A (en) | Traditional Chinese medicine for treatment of abortion disease of pattern of dual vacuity of spleen and kidney |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ren Zhixuan Inventor after: Zhou Guosheng Inventor before: Zhou Guosheng |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHOU GUOSHENG TO: REN ZHIXUAN ZHOU GUOSHENG |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HE PENGFEI Free format text: FORMER OWNER: ZHOU GUOSHENG Effective date: 20130929 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 265500 YANTAI, SHANDONG PROVINCE TO: 225500 TAIZHOU, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130929 Address after: Jiangyan City, Jiangsu Province, 225500 South Road Taizhou City, No. 199 (Jiangyan high tech Venture Center) Realmicro Corporation Patentee after: He Pengfei Address before: 265500 Shandong province Fushan District of Yantai City Huanyu District 2 Building No. 2-6 Patentee before: Zhou Guosheng |
|
| ASS | Succession or assignment of patent right |
Owner name: LAVIANA (TAIZHOU) PHARMACHEM CO., LTD. Free format text: FORMER OWNER: HE PENGFEI Effective date: 20141023 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20141023 Address after: The Jiangyan Economic Development Zone in Jiangsu Province, Taizhou City, 225500 West Road No. 222 Patentee after: Laviana (Taizhou) Pharmachem Co., Ltd. Address before: Jiangyan City, Jiangsu Province, 225500 South Road Taizhou City, No. 199 (Jiangyan high tech Venture Center) Realmicro Corporation Patentee before: He Pengfei |
|
| CP01 | Change in the name or title of a patent holder |
Address after: The Jiangyan Economic Development Zone in Jiangsu Province, Taizhou City, 225500 West Road No. 222 Patentee after: Yue Wei medicine (Jiangsu) Limited by Share Ltd Address before: The Jiangyan Economic Development Zone in Jiangsu Province, Taizhou City, 225500 West Road No. 222 Patentee before: Laviana (Taizhou) Pharmachem Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder |