CN104491587B - The medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy and preparation - Google Patents
The medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy and preparation Download PDFInfo
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- A61K9/2022—Organic macromolecular compounds
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of medicament of hepatic and renal function damage side reaction caused by mitigation chemotherapy, it is characterised in that is prepared by following bulk drugs, is parts by weight：The Radix Astragali 10 20；Reed rhizome 10 20；Coix seed 9 15；Pilose antler 5 10；Salvia chinensis 9 12；Jatamans valeriana rhizome 9 15；Oldenlandia diffusa 6 10；Radix glycyrrhizae 10 15；Dog testes and penis 15 20；The root of kudzu vine 10 16；Semen Cuscutae 6 10；Trichosanthes seed 6 10；White shellfish 8 16；Block close 12 16.The excellent results of the present invention are also manifested by：Medicinal material compatibility is suitable selected by the present invention, meets traditional Chinese medicine and modern medicine research theory, has the effect of nourishing hepatic yin, eliminating dampness and heat, soothing liver-gallbladder, kidney tonifying diuresis；Medicine of the present invention can effectively adjust patient's body function, have good effect, the advantages that having no side effect safely, be worthy to be popularized；Medicine of the present invention is optimal to various Drug lesions of liver and kidney therapeutic effects；Medicine source is easy to get, and medicinal material cost is cheap, can mitigate patient burden.
Description
Technical field
The present invention relates to traditional Chinese medicine field, and side reaction is damaged more particularly to hepatic and renal function caused by a kind of mitigation chemotherapy
Medicament and preparation method.
Background technology
Chemotherapy is the abbreviation of chemotherapy, is to prevent the propagation of cancer cell, infiltration, transfer using chemicals, directly
To a kind of final therapeutic modality for killing cancer cell.It is a kind of systemic treatment means, and operation, radiotherapy are together, and is referred to as
3 big treatment means of cancer.Because chemotherapy is a kind of non-selective " damage sex therapy ", while cancer cell is killed, also damage
The normal histocyte of body, medulla hematopoietic system, increase conscience kidney toxic side effect are hindered.Therefore, chemotherapeutics is being received
When, on the one hand want to reach optimal antitumor action, on the other hand it is also noted that preventing and identifying chemotherapeutics
Adverse reaction.Main Means of the chemotherapy as treating cancer, find the protective agent for reducing chemotherapeutics damage has weight to clinic
Want meaning.
Conventional chemotherapeutics is easier to cause liver dysfunction, is additionally useful for the antibiotics of prevention and treatment infection
And vincristine is drained through liver and gall more, also easily causes liver dysfunction.The diagnosis of the liver damage of caused by chemotherapeutic medicines：
Liver function is normal before chemotherapy, and liver function AST, ALT, AKP rise are checked after treatment with chemotherapy medicine, and bilirubin rise is red with direct courage
Based on element rise.Mark of hepatitis virus is negative.Liver damage the lighter of caused by chemotherapeutic medicines has found liver without any symptom, during inspection
Dysfunction is mostly that transience transaminase raises, and after prolonged application chemotherapeutic, can cause chronic liver disease.
The A of application publication number CN 103920034（Application number 201410144869.3）Chinese patent literature disclose
A kind of Chinese medicine composition for mitigating Chemotherapy on Patient with Tumor side reaction, takes the primary raw material of following weight proportions to be prepared：Blue or green bamboo
Eat 6-12 parts, the bighead atractylodes rhizome（Bran is fried）6-15 parts, coptis 4-8 parts, red sage root 6-12 parts, bletilla 5-12 parts, rheum officinale 3-6 parts, scouring rush 5-11
Part, bark of official magnolia 6-12 parts, indigo naturalis 3-6 parts, rhizoma cyperi（Vinegar）4-8 parts, myrrh 6-18 parts, costus root 6-12 parts, chorion ovi 9-15 parts, day
The smart 4-9 parts of name, pinellia 4-12 parts.The A of publication number CN 1453027（Application number 0311877.2）Chinese patent literature disclose
A kind of prevention slows down preparation of side effects of chemotherapy and preparation method thereof, is formed by following compositions configuration：Red ginseng 15-24g, it is yellow
Stilbene 15-24g, Radix Angelicae Sinensis 6-12g, asparagus fern 15-24g, psoralea corylifolia 10-15g, fruit of Chinese wolfberry 9-15g, cortex acanthopanacis 6-10g, red sage root 8-12g,
Honeysuckle 8-12g, radix glycyrrhizae 5-8g.The A of publication number CN 101143191（Application number 200610017180.X）Chinese patent text
Offer and disclose a kind of medicine for mitigating breast cancer Radiotherapy chemotherapy side effect, the raw material matched by following weight is made：Radix Astragali 25-35, people
Join 10-20, cultivated land 15-25, deer horn glue 7-13, tortoise glue 7-13, rhizoma Gastrodiae 10-20, silk 10-20, fruit of glossy privet 10-20, matrimony vine 10-
20, ox sunset 10-20, asarum 10-20, cassia seed 7-13, damp sunset 7-13, frankincense 10-20, myrrh 10-20, vomiting nut 1-3.
At present using infringement of the prevention such as Glucurolactone to liver function, using aquation, alkalized urine, reduce uric acid and produce,
The measures such as uric acid excretion are promoted to prevent the infringement to renal function.The side effect of protection medicine in itself：For single symptom, make purposes
Footpath is single；New drug is expensive, limits Clinical practice；New drug late result is still imprecise.Etc. be Western medicine mitigate chemotherapy
The problem of existing in terms of toxic side effect.Traditional chinese medicine medicament can comprehensive adjustment, heresy just take into account, restrict chemotherapeutics to a certain extent
Toxicity, reduce the pain of patient, strengthen its resistance against diseases, ensure the implementation of chemotherapy regimen.
The content of the invention
In view of the shortcomings of the prior art, one kind simple, quick, that curative effect is short is prepared it is an object of the invention to provide a kind of
The medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy and preparation.The medicament mild in medicine property and and have no toxic side effect.
The technical scheme is that：
The medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy, it is characterised in that it is prepared by following bulk drugs,
It is parts by weight：Radix Astragali 10-20；Reed rhizome 10-20；Coix seed 9-15；Pilose antler 5-10；Salvia chinensis 9-12；Jatamans valeriana rhizome 9-15；White flower
HERBA HEDYOTIS DIFFUSAE 6-10；Radix glycyrrhizae 10-15；Dog testes and penis 15-20；Root of kudzu vine 10-16；Semen Cuscutae 6-10；Trichosanthes seed 6-10；White shellfish 8-16；Block close
12-16。
In preferable scheme, Radix Astragali 12-18；Reed rhizome 12-18；Coix seed 11-13；Pilose antler 6-9；Salvia chinensis 10-11；Spider
Fragrant 11-13；Oldenlandia diffusa 7-9；Radix glycyrrhizae 11-14；Dog testes and penis 16-19；Root of kudzu vine 12-14；Semen Cuscutae 7-9；Trichosanthes seed 7-9；White shellfish
11-13；Block close 13-15.
More preferred, the Radix Astragali 15；Reed rhizome 15；Coix seed 12；Pilose antler 7.5；Salvia chinensis 10.5；Jatamans valeriana rhizome 12；Long-noded pit viper
Tongue grass 8；Radix glycyrrhizae 12.5；Dog testes and penis 17.5；The root of kudzu vine 13；Semen Cuscutae 8；Trichosanthes seed 8；White shellfish 12；Block close 14.
The medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy, the preparation method of the decoction are：
（1）To block it is close clean, put in heat container, heated with moderate heat, fried to medical surfaces in sallow or burnt brown, internal face
Color is deepened, and stopped when having burnt odor gas, grinds, standby；White shellfish is cleaned, and is placed in container, heats with high heat, roasts to surface in Jiao
Stop during brown, smash to pieces, pulverization is standby；
（2）Take piece of antler to put on slow fire to warm, put into yellow rice wine and quench, dry after quenching, be sucked to yellow rice wine again, then burnt to ash
Yellow, side plays vesicle and has crisp fragrance, dries in the air cool, be ground into fine powder, standby；Coix seed is placed in pulverizer, is ground into smalls, standby
With；
（3）By step（1）And step（2）Gained fine powder mixes, and sieving, obtains mixing fine powders；
（4）Jatamans valeriana rhizome is cleaned, section, is placed in immersion 25-45 minutes in white wine（It is preferably disposed in white wine and soaks 35 minutes）,
Take out, marmite is together placed in the Radix Astragali, reed rhizome, salvia chinensis, oldenlandia diffusa, radix glycyrrhizae, dog testes and penis, the root of kudzu vine, Semen Cuscutae and trichosanthes seed
In, add the distilled water of 5-9 times of medicinal material amount to soak 2-4 hours at 30-40 DEG C（It is preferable at 35 DEG C and soaks 3 hours）, intense fire boils
Boiling, turn to be cooked by slow fire 2-4 hours（It is preferred that decoct 3 hours）, filtering, obtain decocting liquid；
（5）Step is added into above-mentioned decocting liquid（3）Gained mixing fine powders, continue heating and decoct 20-40 minutes, filtering, go out
Bacterium 12-24 minutes, encapsulation, produce.
The preparation method of the decoction of the damage side reaction of hepatic and renal function caused by above-mentioned mitigation chemotherapy, preferable scheme is step
（3）It is middle to cross 90-130 mesh sieves（It is preferable to cross 100-120 mesh sieves, the more preferred mesh sieve of mistake 110）.
The preparation method of the decoction of the damage side reaction of hepatic and renal function caused by above-mentioned mitigation chemotherapy, preferable scheme is step
（5）The temperature of middle sterilizing is 95-115 DEG C（The temperature preferably to sterilize is 100-110 DEG C, and the temperature of more preferred sterilizing is
105℃）.
The preparation method of the pill is：
（1）Reed rhizome is put into pot after cleaning, and adds the 2-5 times of clear water measured（It is preferably added to the clear water of 3.5 times of amounts）, big fire decocts
Boil 12-24 minutes（It is preferred that big fire decocts 18 minutes）, filter cleaner, taking juice is standby；
（2）White shellfish, Ka Mi and pilose antler, are placed in hot pot, intense fire heating, roast and stop when being in burnt brown to surface, smash to pieces, grind
Into smalls, sieving, it is standby to obtain mixing fine powders；Coix seed is placed in pulverizer, is ground into smalls, standby；
（3）Jatamans valeriana rhizome, Semen Cuscutae and trichosanthes seed are cleaned respectively, are placed in extractor, addition mass fraction is 70%-90%
Ethanol（It is preferably added to the ethanol that mass fraction is 80%）, after impregnating 24-36 minutes（It is preferred that dipping is after 30 minutes）, heat back
Stream extraction twice, extracts 1.5-2.5 hours for the first time（Preferable extraction 2 hours for the first time）, second of extraction 1-1.5 hour
（Preferable second of extraction 1.8 hours）, the addition of each ethanol is 5-8 times of medicinal material amount, merges alcohol extract, is recovered under reduced pressure
Ethanol, relative density is 1.30-1.33 thick paste 1 when being concentrated into 65 DEG C；
（4）By step（2）Gained coix seed powder and the Radix Astragali, salvia chinensis, oldenlandia diffusa, radix glycyrrhizae, dog testes and penis and the root of kudzu vine are together
It is placed in non iron container, adds the 6-9 times of pure water measured immersion 1.8-2.6 hour（It is preferably added to the pure water logging of 7.5 times of amounts
Bubble 2.2 hours）, change after boiling by intense fire and be cooked by slow fire twice, decoct 70-110 minutes for the first time（It is preferred that 90 points are decocted for the first time
Clock）, second of decoction 35-55 minute（It is preferred that second decocts 45 minutes）, filtering, merge decocting liquid twice, add step（1）Institute
Juice is obtained, mixing, paste is concentrated under reduced pressure into, obtains thick paste 2；
（5）By step（3）Gained thick paste 1 and step（4）Gained thick paste 2 mixes, and adds step（2）Gained mixing fine powders,
Stir, be processed into pill, produce.
The preparation method of the pill of the damage side reaction of hepatic and renal function caused by above-mentioned mitigation chemotherapy, preferable scheme is step
（2）It is middle to cross 120-160 mesh sieves（It is preferable to cross 130-150 mesh sieves, the more preferred mesh sieve of mistake 140）.
The preparation method of the tablet is：
（1）Take honey to add water-solubleization, pour into piece of antler, mix thoroughly, taken out after exhausting, put and 1-3 hours are steamed in food steamer,
Taking-up is dried, and is ground standby；White shellfish, block close, Semen Cuscutae and trichosanthes seed, be placed in hot pot, intense fire heating, roast to surface in burnt brown
Stop during color, smash to pieces, pulverization is standby；Coix seed is placed in pulverizer, is ground into smalls, standby；
（2）Jatamans valeriana rhizome, oldenlandia diffusa, the Radix Astragali, salvia chinensis, reed rhizome, radix glycyrrhizae, the root of kudzu vine and dog testes and penis are together placed in marmite,
Add the 5-7 times of pure water measured to soak 1.5 hours, change after boiling by intense fire and be cooked by slow fire twice, decoct 45-65 minutes for the first time,
Second of decoction 25-45 minute, filtering, merge decocting liquid twice, it is 1.30-1.35's that decocting liquid, which continues to be concentrated into 75 DEG C of relative densities,
Clear cream, spray drying, obtains dry extract；
（3）By step（1）Gained fine medicinal material powder and step（2）Gained dry extract mixes, and stirs, and crosses 70-130 mesh
Sieve（It is preferred that cross 100 mesh sieves）, hydroxypropyl methylcellulose, cornstarch and dextrin are added into mixing fine powders（Medicinal powder：Hypromellose
Element：Cornstarch：Dextrin is 10:1.1:1:0.7）, tablet is made, produces.
The preparation method of the thick paste agent is：
（1）Net licorice tablet is taken, the refined honey diluted with boiling water pours leaching, mixes thoroughly, vexed profit, puts in frying container, slow fire heating,
Fry to strong yellow, when tack-free, taking-up cools；
（2）Take honey to add water-solubleization, pour into piece of antler, mix thoroughly, taken out after exhausting, put and 1-3 hours are steamed in food steamer,
Taking-up is dried, and is ground standby；White shellfish, block close, Semen Cuscutae and trichosanthes seed, be placed in hot pot, intense fire heating, roast to surface in burnt brown
Stop during color, smash to pieces, cross 90-150 mesh sieves（It is preferred that cross 120 mesh sieves）, pulverization is standby；Coix seed is placed in pulverizer, powder
Smalls is broken into, it is standby；
（3）By step（1）Licorice tablet after processing and jatamans valeriana rhizome, oldenlandia diffusa, the Radix Astragali, salvia chinensis, reed rhizome, the root of kudzu vine and
Dog testes and penis is together placed in marmite, and the pure water for adding 6 times of amounts soaks 1.2-1.8 hours in 40 DEG C（Be preferably added to 6 times amount it is pure
Water soaks 1.5 hours in 40 DEG C）, change after boiling by intense fire and be cooked by slow fire twice, decoct 40-70 minutes for the first time（It is preferred that for the first time
Decoct 65 minutes）, second of decoction 30-40 minute（It is preferred that second decocts 35 minutes）, filtering, merge decocting liquid twice；
（4）Step is added into above-mentioned decocting liquid（2）Gained fine powder, paste is concentrated under reduced pressure into, cooled down, dry sterilization, i.e.,
.
Scientific formula of the present invention, the preparation method of various formulations is simple, and products obtained therefrom is convenient to take, significant effect.Except this
Outside, excellent results of the invention are also manifested by：
1、Medicinal material compatibility is suitable selected by the present invention, meets traditional Chinese medicine and modern medicine research theory, with nourishing hepatic yin, clearly
Dampness removing heat, soothing liver-gallbladder, the effect of kidney tonifying diuresis.
2、Medicine of the present invention can effectively adjust patient's body function, have good effect, the advantages that having no side effect safely, be worth
Promote.
3、Medicine of the present invention is optimal to various Drug lesions of liver and kidney therapeutic effects；Medicine source is easy to get, and medicinal material cost is cheap, energy
Enough mitigate patient burden.
Embodiment
Technical scheme, but protection domain not limited to this are described in detail with reference to embodiment and experimental example.
The pharmacology of main Chinese medicine material is as follows used in the present invention：
Jatamans valeriana rhizome：Base：For the rhizome of Valerianaceae platymiscium jatamans valeriana rhizome.Composition：Root and rhizome mainly contain volatile ingredient,
Also contain caffeic acid.Pharmacology：Central nervous is inhibited, there is antineoplastic action.The property of medicine：It is pungent, slight bitter, temperature.Function
Cure mainly：Qi-regulating is with, dispelling cold and removing dampness, activating blood circulation and reducing swelling.
White shellfish：Base：For the shell of Cypraeidae Cypraeamoneta category animal Cypraeamoneta, ring grain Cypraeamoneta etc..Composition：Ring grain Cypraeamoneta shell is containing height
The acidic amino acid property of medicine of content：It is salty, it is cool.Return bladder, Liver Channel.Function cures mainly：Reducing fever and causing diuresis, removing nebula.Aqueous vapor is cured mainly to float
It is swollen, drench pain diuresis, urinary obstruction, ocular of looking unfamiliar, nasosinusitis purulence blood, the chancre erosion of vulva.
Block close：Also known as Nitraria sibirica fruit, acid are fat, the fruit pierced in vain for zygophyllaceae Nitraria plant nitraria schoberi and tingia
It is real.The property of medicine：It is sweet, sour, it is warm-natured.Composition：Nitraria schoberi herb is containing white thorn quinolizine amine, different white thorn quinolinamine, it is white pierce imidazoles alkali and
Nitraria schoberi alkali.Found according to modern pharmacological research, the medical instrument has the effect of strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood, for body
Body is thin and weak, qi-blood deficiency, incoordination between the spleen and the stomach, waist abdomen pain.
The Radix Astragali：Base：This product is the dry root of legume astragalus mongolicus or Astragalus membranacus.Nature and flavor：It is sweet, temperature.Channel tropism：Return
Lung, the spleen channel.Effect：Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.Cure mainly：For treatment deficiency of vital energy weak, anorexia and loose stool, middle gas
It sink, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes；
Chronic rephrilis protinuria, diabetes.
Reed rhizome：Base：For the rhizome of grass reed.Chemical analysis：Reed rhizome contains Coixol, and protein 5%,
Fat 1%, carbohydrate 51%, asparagine 0.1%.Reed containing cellulose 48~54%, lignin about 18.2%, wood are poly-
Sugar about 12.4%, ash content 2.8%.Polysaccharide hydrolysis produces D- xyloses, L-arabinose, D-Glucose, D- galactolipins and two kinds of sugar
Aldehydic acid.Another vitamin B1 containing volume, B2 and C, and Tricin.Nature and flavor：It is sweet, tremble with fear.Channel tropism：Enter lung, stomach.Major function：Clearly
Heat, promote the production of body fluid, relieving restlessness, preventing or arresting vomiting.Pyreticosis polydipsia is controlled, gastropyretic vomiting is dysphagic, gastric disorder causing nausea, consumptive lung disease, lung carbuncle.And solve filefish ichthyotoxin.
Coix seed：Base：For the benevolence of grass Job's tears.Chemical analysis：Benevolence contains protein 16.2%, fat
4.65%, carbohydrate 79.17%, a small amount of vitamin B1（330 microgram %）.Seed contains amino acid（For leucine, lysine,
Arginine, tyrosine etc.）, Coixol, Coixenolide, triterpenoid.Pharmacological action：1. the effect of coix seed oil：Use petroleum ether
The coix seed oil of leaching is to the striated muscle and motor nerve ending of the frog, and low concentration is in excitation, and high concentration acts in paralysis.②
The effect of Coixol：There is inhibitory action to striated muscle.Nature and flavor：It is sweet light, it is cool.Channel tropism：Enter spleen, lung, kidney channel.Major function：Invigorating the spleen,
Tonifying lung, heat-clearing, dampness removing.Control diarrhea, arthritis with fixed pain caused by dampness, muscle arteries and veins contraction, joint stuffiness, oedema, tinea pedis, consumptive lung disease, lung carbuncle, acute appendicitis, stranguria with turbid discharge, in vain
Band.
Pilose antler：Base：For the not yet ossified young horn of animal in deer family sika deer or red deer.Nature and flavor：Gan Xian, temperature.Channel tropism：Enter
Liver and kidney channel.Major function：Kidney-Yang invigorating, fill blood, benefiting quintessence, strengthening the bones and muscles.It is thin thin to control consumptive disease, spiritual tired weary, dizziness, deaf, mesh
Secretly, soreness of waist and knee joint, impotence, involuntary emission；Uterus void is cold, uterine bleeding, under band.
Salvia chinensis：Base：For the herb of labiate salvia chinensis.Chemical analysis：Herb is containing sterol, Triterpenoid, amino
Acid.Root contains stachyose.Nature and flavor：《This production of Suzhou medicinal material》：" toil, put down." major function：Dysphagic, asthma due to excessive phlegm is controlled, hepatitis is red white
Band, carbuncle swells, scrofula.
Oldenlandia diffusa：Base：For the whole herb with root of madder kind plant oldenlandia diffusa.Chemical analysis：Separated in herb
1 alkane, stigmasterol, ursolic acid, oleanolic acid, cupreol, cupreol-D-Glucose glucoside, p-Coumaric Acid etc..Pharmacology is made
With：1. antitumor action, 2. antibacterial, antiinflammation, nature and flavor：Bitter sweet, tremble with fear.Nature and flavor：Bitter sweet, tremble with fear.Major function：Heat-clearing, dampness removing,
Removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Sphagitis, appendicitis, dysentery, urinary tract infections, jaundice, hepatitis, pelvic infecton, adnexitis,
Carbuncle swells furunculosis, venomous snake bite, tumour.Also it can be used for alimentary tract cancer.
Radix glycyrrhizae：Base：This product is the dry report and rhizome of glycyrrhizic legume, swollen fruit Radix or glycyrrhiza glabra.Nature and flavor：
It is sweet, put down.Channel tropism：The thoughts of returning home.Lung, spleen, stomach.Effect：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
Cure mainly：For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, institute's abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate
It is drug toxicity, strong.
Dog testes and penis：Base：For penis of the Canidae Canis Animals Male dog with testis.【Chemical composition】Containing male sex hormone, albumen
Matter, fat etc..Nature and flavor：Taste is salty, warm-natured.Channel tropism：Return kidney channel.With warming kidney and enhancing body, the effect of strengthening and nourishing marrow and essence；Impotence is cured mainly, is lost
Essence, male infertility, scrotum is clammy, and soreness and weakness of waist and knees, body is thin and weak, under woman's cold of insufficiency type band, postpartum weakness.
The root of kudzu vine：Base：This product is the dry root of legume pueraria lobata.Character：This product is in the rectangle sheet or small of rip cutting
Square.Crust light brown, there is vertical wrinkle, it is coarse.Section yellow-white, texture unobvious.Matter is tough, and fibroid is strong.Nature and flavor：It is sweet, pungent,
It is cool.Channel tropism：Returns spleen, stomach.Effect：Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.Cure mainly：For fever caused by exogenous pathogens headache, person's back
Strong pain, it is thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, diarrhea；Hypertension neck pain.
Semen Cuscutae：Source：This product is the dry mature seed of Cuscuta chinensis Lam..Nature and flavor：It is sweet, temperature.Channel tropism：Return
Liver,kidney,spleen passes through.Major function：Nourishing liver and kidney, astringent sperm contracting urine is antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, lose
Urine frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen kidney deficiency are rushed down；Externally treating leucoderma.
Trichosanthes seed：Base：For the seed of cucurbitaceous plant snakegourd or trichosanthes rosthornii Harms, big sub- snakegourd etc..Chemical analysis：Snakegourd
Benevolence contains glucoside, saponin, organic acid and its esters（Such as calcium oxalate）, natural gum, resin, fat oil and pigment etc..Fat oil is about containing rate
26%, wherein saturated fatty acid accounts for 30%, and unsaturated person accounts for 66.5%；Unrighted acid is based on trichosanic acid.Nature and flavor：
It is sweet, tremble with fear.Channel tropism：Enter lung, stomach, large intestine channel.Major function：Moistening lung, resolving sputum, laxation.Control phlegm-heat cough, constipation constipation, carbuncle swells, breast
It is few.
The medicament of the damage side reaction of hepatic and renal function caused by embodiment 1 mitigates chemotherapy, it is characterised in that by following bulk drugs
It is prepared, is parts by weight（50g/ parts）：10 parts of the Radix Astragali；10 parts of reed rhizome；9 parts of coix seed；5 parts of pilose antler；9 parts of salvia chinensis；Spider
Spider is fragrant 9 parts；6 parts of oldenlandia diffusa；10 parts of radix glycyrrhizae；15 parts of dog testes and penis；10 parts of the root of kudzu vine；6 parts of Semen Cuscutae；6 parts of trichosanthes seed；White 8 parts of shellfish；
Block close 12 parts.
The preparation method of the decoction of hepatic and renal function damage side reaction is caused by mitigation chemotherapy：
（1）To block it is close clean, put in heat container, heated with moderate heat, fried to medical surfaces in sallow or burnt brown, internal face
Color is deepened, and stopped when having burnt odor gas, grinds, standby；White shellfish is cleaned, and is placed in container, heats with high heat, roasts to surface in Jiao
Stop during brown, smash to pieces, pulverization is standby；
（2）Take piece of antler to put on slow fire to warm, put into yellow rice wine and quench, dry after quenching, be sucked to yellow rice wine again, then burnt to ash
Yellow, side plays vesicle and has crisp fragrance, dries in the air cool, be ground into fine powder, standby；Coix seed is placed in pulverizer, is ground into smalls, standby
With；
（3）By step（1）And step（2）Gained fine powder mixes, and crosses 100 mesh sieves, obtains mixing fine powders；
（4）Jatamans valeriana rhizome is cleaned, and section, is placed in white wine and is soaked 25 minutes, is taken out, with the Radix Astragali, reed rhizome, salvia chinensis, white flower
HERBA HEDYOTIS DIFFUSAE, radix glycyrrhizae, dog testes and penis, the root of kudzu vine, Semen Cuscutae and trichosanthes seed are together placed in marmite, add the distilled water of 5-9 times of medicinal material amount in 30
Soak 2 hours, boil by intense fire at DEG C, turn to be cooked by slow fire 2 hours, filter, obtain decocting liquid；
（5）Step is added into above-mentioned decocting liquid（3）Gained mixing fine powders, continue heating and decoct 20 minutes, filtering, 100 DEG C
Sterilizing 12 minutes, encapsulation, is produced.
The instructions of taking of decoction of the present invention is：Twice daily, each 200-300mL, 5 days courses for the treatment of.
Model case：Pungent XX, female, 47 years old, on October 19th, 2012, patient was with " poorly differentiated adenocarcinoma art in antral ulcer type
Afterwards after chemotherapy after more lymphatic metastasis chemotherapy " it is chief complaint and is admitted to hospital.After patient uses the cycle of FOLFI-RI scheme chemotherapies 2, occur light
Nausea and vomiting is spent, appetite is poor.Tongue fur is yellowish, the thin string of arteries and veins.Lesions of liver and kidney caused by being diagnosed as chemotherapy.
Take decoction obtained by the present embodiment, instructions of taking：Twice daily, each 200-300mL, 5 days courses for the treatment of.Treatment
After two courses for the treatment of, patient's liver function is clearly better, and other symptoms mitigate, after continuing taking the two courses, the inspection of patient's hepatic and renal function
Look into normally, patient smoothly completes chemotherapy discharge.
The medicament of the damage side reaction of hepatic and renal function caused by embodiment 2 mitigates chemotherapy, it is characterised in that by following bulk drugs
It is prepared, is parts by weight（30g/ parts）：20 parts of the Radix Astragali；20 parts of reed rhizome；15 parts of coix seed；10 parts of pilose antler；12 parts of salvia chinensis；
15 parts of jatamans valeriana rhizome；10 parts of oldenlandia diffusa；15 parts of radix glycyrrhizae；20 parts of dog testes and penis；16 parts of the root of kudzu vine；10 parts of Semen Cuscutae；10 parts of trichosanthes seed；In vain
16 parts of shellfish；Block close 16 parts.
The preparation method of the pill of hepatic and renal function damage side reaction is caused by mitigation chemotherapy：
（1）Reed rhizome is put into pot after cleaning, and adds the clear water of 3.5 times of amounts, and big fire decocts 18 minutes, filter cleaner, takes juice
Liquid is standby；
（2）White shellfish, Ka Mi and pilose antler, are placed in hot pot, intense fire heating, roast and stop when being in burnt brown to surface, smash to pieces, grind
Into smalls, 140 mesh sieves are crossed, it is standby to obtain mixing fine powders；Coix seed is placed in pulverizer, is ground into smalls, standby；
（3）Jatamans valeriana rhizome, Semen Cuscutae and trichosanthes seed are cleaned respectively, are placed in extractor, adds the second that mass fraction is 80%
Alcohol, dipping is after 30 minutes, and twice, extraction 2 hours, are extracted 1.8 hours heating and refluxing extraction for the second time for the first time, each ethanol
Addition is 6.5 times of medicinal material amount, merges alcohol extract, ethanol is recovered under reduced pressure, relative density is 1.30- when being concentrated into 65 DEG C
1.33 thick paste 1；
（4）By step（2）Gained coix seed powder and the Radix Astragali, salvia chinensis, oldenlandia diffusa, radix glycyrrhizae, dog testes and penis and the root of kudzu vine are together
It is placed in non iron container, the pure water for adding 7.5 times of amounts soaks 2.2 hours, changes after boiling by intense fire and is cooked by slow fire twice, and first
It is secondary to decoct 90 minutes, second of decoction 45 minutes, filtering, merge decocting liquid twice, add step（1）Gained juice, mix, decompression
Paste is condensed into, obtains thick paste 2；
（5）By step（3）Gained thick paste 1 and step（4）Gained thick paste 2 mixes, and adds step（2）Gained mixing fine powders,
Stir, be processed into pill, produce.
The instructions of taking of pill of the present invention is：Three times a day, each 4-6 balls, 5 days courses for the treatment of.
Model case：XX, female, 42 years old, patient because left infiltration ductal carcinomas of breast is with Thoracolumbar disk Bone tumour PT4N3M1,
IV phase came our hospital in July, 2010 and treated.Check that hepatic and renal function is normal before chemotherapy.August uses CEF (CTX on 3rd within 2010
0.8 d1、d8；EPI 100mg d1；Fluridine 1.0 d1, d8) scheme progress chemotherapy, when chemotherapy carries out second round, patient
There is weak shortness of breath, lose the appetite, the soreness of waist, nausea, lower limb are slight edema, veins string, pink tongue, white,slippery and moist fur.It is diagnosed as Drug
Lesions of liver and kidney.
Take pill obtained by the present embodiment, instructions of taking：Three times a day, each 4-6 balls, 5 days courses for the treatment of.Take two
After the course for the treatment of, patient's malaise symptoms are relieved, and appetite is gradually recovered, two courses for the treatment of of continual cure, and patient is checking hepatic and renal function just
Often, symptom disappears.
The medicament of the damage side reaction of hepatic and renal function caused by embodiment 3 mitigates chemotherapy, it is characterised in that by following bulk drugs
It is prepared, is parts by weight（45g/ parts）：12 parts of the Radix Astragali；12 parts of reed rhizome；11 parts of coix seed；6 parts of pilose antler；10 parts of salvia chinensis；
11 parts of jatamans valeriana rhizome；7 parts of oldenlandia diffusa；11 parts of radix glycyrrhizae；16 parts of dog testes and penis；12 parts of the root of kudzu vine；7 parts of Semen Cuscutae；7 parts of trichosanthes seed；White shellfish
11 parts；Block close 13 parts.
The preparation method of the tablet of hepatic and renal function damage side reaction is caused by mitigation chemotherapy：
（1）Take honey to add water-solubleization, pour into piece of antler, mix thoroughly, taken out after exhausting, put and steamed in food steamer 1.5 hours,
Taking-up is dried, and is ground standby；White shellfish, block close, Semen Cuscutae and trichosanthes seed, be placed in hot pot, intense fire heating, roast to surface in burnt brown
Stop during color, smash to pieces, pulverization is standby；Coix seed is placed in pulverizer, is ground into smalls, standby；
（2）Jatamans valeriana rhizome, oldenlandia diffusa, the Radix Astragali, salvia chinensis, reed rhizome, radix glycyrrhizae, the root of kudzu vine and dog testes and penis are together placed in marmite,
The pure water for adding 6 times of amounts soaks 1.5 hours, changes after boiling by intense fire and is cooked by slow fire twice, decocts 55 minutes for the first time, second
Decoct 35 minutes, filtering, merge decocting liquid twice, decocting liquid continues to be concentrated into the clear cream that 75 DEG C of relative densities are 1.30-1.35, spraying
Dry, obtain dry extract；
（3）By step（1）Gained fine medicinal material powder and step（2）Gained dry extract mixes, and stirs, and crosses 100 mesh sieves,
Hydroxypropyl methylcellulose, cornstarch and dextrin are added into mixing fine powders（Medicinal powder:Hydroxypropyl methylcellulose:Cornstarch:Dextrin is
10:1.1:1:0.7）, tablet is made, produces.
The instructions of taking of Tablets is：Three times a day, each 4-6 pieces, 5 days courses for the treatment of.
Model case：King XX, 53 years old, people from Shandong, advanced esophageal cancer, in December, 2011, operation, cut off one section very long
Esophagus, 2011 2 month disease relapse, proceed by chemotherapy.Check that patient's hepatic and renal function is normal before chemotherapy, chemotherapy is carried out
After a cycle, there is vomiting, without appetite, the slight oedema of upper limbs in patient, and tongue fur is yellowish, and arteries and veins carefully omits string.It is diagnosed as caused by chemotherapy
Lesions of liver and kidney.
Take the tablet of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy obtained by the present embodiment, instructions of taking：Daily three
It is secondary, each 4-6 pieces, 5 days courses for the treatment of.After taking two courses for the treatment of, patient's symptoms of emesis is alleviated significantly, and oedema mitigates, and continues to use
Two courses for the treatment of of medicine, patient's malaise symptoms disappear, and continue medication in later stage chemotherapy then and are prevented and treated, patient produces without other side effects
It is raw.
The medicament of the damage side reaction of hepatic and renal function caused by embodiment 4 mitigates chemotherapy, it is characterised in that by following bulk drugs
It is prepared, is parts by weight（35g/ parts）：18 parts of the Radix Astragali；18 parts of reed rhizome；13 parts of coix seed；9 parts of pilose antler；11 parts of salvia chinensis；
13 parts of jatamans valeriana rhizome；9 parts of oldenlandia diffusa；14 parts of radix glycyrrhizae；19 parts of dog testes and penis；14 parts of the root of kudzu vine；9 parts of Semen Cuscutae；9 parts of trichosanthes seed；White shellfish
13 parts；Block close 15 parts.
The preparation method of the thick paste agent of hepatic and renal function damage side reaction is caused by mitigation chemotherapy：
（1）Net licorice tablet is taken, the refined honey diluted with boiling water pours leaching, mixes thoroughly, vexed profit, puts in frying container, slow fire heating,
Fry to strong yellow, when tack-free, taking-up cools；
（2）Take honey to add water-solubleization, pour into piece of antler, mix thoroughly, taken out after exhausting, put and steamed in food steamer 1.5 hours,
Taking-up is dried, and is ground standby；White shellfish, block close, Semen Cuscutae and trichosanthes seed, be placed in hot pot, intense fire heating, roast to surface in burnt brown
Stop during color, smash to pieces, cross 120 mesh sieves, pulverization is standby；Coix seed is placed in pulverizer, is ground into smalls, standby；
（3）By step（1）Licorice tablet after processing and jatamans valeriana rhizome, oldenlandia diffusa, the Radix Astragali, salvia chinensis, reed rhizome, the root of kudzu vine and
Dog testes and penis is together placed in marmite, and the pure water for adding 6 times of amounts soaks 1.5 hours in 40 DEG C, changes after boiling by intense fire and is cooked by slow fire two
It is secondary, decoct 65 minutes for the first time, second of decoction 35 minutes, filtering, merge decocting liquid twice；
（4）Step is added into above-mentioned decocting liquid（2）Gained fine powder, paste is concentrated under reduced pressure into, cooled down, dry sterilization, i.e.,
.
The instructions of taking of thick paste agent of the present invention is：Twice daily, each 2-3 spoons, warm boiled water, 5 days courses for the treatment of.
Model case：Grandson XX, man, 62 years old, people from Junan.Patient's readme：On May 7th, 2011 is white because of acute monocytic
Blood disease carries out chemotherapy.On May 23rd, 2011 chemically examines liver function result：S-GPT106 units, TTT8.4 units, TFT++.Patient
Slightly refer to spill edema, veins string, pink tongue, white,slippery and moist fur with weak shortness of breath, poor appetite, the soreness of waist, nausea, lower limb.It is diagnosed as
Liver dysfunction caused by chemotherapy.
Take obtained by the present embodiment, instructions of taking：Twice daily, each 2-3 spoons, warm boiled water, 5 days courses for the treatment of.
Symptom is obviously improved after two courses for the treatment of of treatment, and July 5, liver function test result was normal twice with July 23, and patient has disabled
Chemotherapy, using traditional Chinese medical science after treatment.Follow-up after half a year, patient's liver function test are normal.
The medicament of the damage side reaction of hepatic and renal function caused by embodiment 5 mitigates chemotherapy, it is characterised in that by following bulk drugs
It is prepared, is parts by weight（40g/ parts）：15 parts of the Radix Astragali；15 parts of reed rhizome；12 parts of coix seed；7.5 parts of pilose antler；Salvia chinensis 10.5
Part；12 parts of jatamans valeriana rhizome；8 parts of oldenlandia diffusa；12.5 parts of radix glycyrrhizae；17.5 parts of dog testes and penis；13 parts of the root of kudzu vine；8 parts of Semen Cuscutae；Trichosanthes seed 8
Part；White 12 parts of shellfish；Block close 14 parts.
The preparation method of the decoction of hepatic and renal function damage side reaction is caused by mitigation chemotherapy：
（1）To block it is close clean, put in heat container, heated with moderate heat, fried to medical surfaces in sallow or burnt brown, internal face
Color is deepened, and stopped when having burnt odor gas, grinds, standby；White shellfish is cleaned, and is placed in container, heats with high heat, roasts to surface in Jiao
Stop during brown, smash to pieces, pulverization is standby；
（2）Take piece of antler to put on slow fire to warm, put into yellow rice wine and quench, dry after quenching, be sucked to yellow rice wine again, then burnt to ash
Yellow, side plays vesicle and has crisp fragrance, dries in the air cool, be ground into fine powder, standby；Coix seed is placed in pulverizer, is ground into smalls, standby
With；
（3）By step（1）And step（2）Gained fine powder mixes, and crosses 110 mesh sieves, obtains mixing fine powders；
（4）Jatamans valeriana rhizome is cleaned, and section, is placed in white wine and is soaked 35 minutes, is taken out, with the Radix Astragali, reed rhizome, salvia chinensis, white flower
HERBA HEDYOTIS DIFFUSAE, radix glycyrrhizae, dog testes and penis, the root of kudzu vine, Semen Cuscutae and trichosanthes seed are together placed in marmite, add the distilled water of 7 times of medicinal material amounts in 35 DEG C
Lower immersion 3 hours, is boiled by intense fire, is turned to be cooked by slow fire 3 hours, is filtered, obtain decocting liquid；
（5）Step is added into above-mentioned decocting liquid（3）Gained mixing fine powders, continue heating and decoct 30 minutes, filtering, 105 DEG C
Sterilize 12-24 minutes, encapsulation, produce.
The instructions of taking of decoction of the present invention is：Twice daily, each 200-300mL, 5 days courses for the treatment of.
The medicament of hepatic and renal function damage side reaction caused by the present invention gained of test example 1 mitigates chemotherapy（Embodiment 5）Clinic
Using：
1st, data and method
1.1 general information
In May, -2013 in October, 2010, choose 227 malignant tumor patients for carrying out our hospital's treatment.Wherein male patient
120, female patient 107；Oldest 72 years old, 30 years old of age minimum.Wherein squamous cell carcinoma patients 53, patients with gastric cancer 64
Example, esophageal cancer patients 47, breast cancer 63.
1.2 selection standard
（1）The malignant tumor patient made a definite diagnosis through Histopathology or cytology；（2）It is more than the cycle to receive at least two or 2
Chemotherapy, it is contemplated that existence>4 months；（3）Hepatic and renal function is normal before chemotherapy；（4）By coherence check exclude virus hepatitis and
Other renal system diseases.
1.3 treatment method
All patients are randomly divided into two groups, treatment group and control group, treatment group：Chemotherapy+take products obtained therefrom of the present invention, clothes
It is with method：Twice daily, each 200-300mL, 5 days courses for the treatment of.Control group chemotherapy+take other medicines（Such as bicyclic alcohols
The conventional medications such as piece, Tiopronin, five clever piece of Six-element）.Observation two cycles for the treatment of altogether.Two groups in the side such as age, sex, state of an illness
Face has comparativity.
1.4 efficacy assessment standard
Cure：Malaise symptoms disappear, and hepatic and renal function checks continuous 3 subnormal person；It is effective：Malaise symptoms disappear substantially, liver
Kidney function test continuous 2 is subnormal, or one course for the treatment of above hepatic and renal function for the treatment of starts to recover normal person；Effectively：Cardinal symptom
Disappear or basic disappearance, hepatic and renal function check that former exceptional value declines more than 50% person；It is invalid：Symptom without improvement, though or have improvement and
Hepatic and renal function is without improvement.
Total effective rate=（Cure number of cases+effective number of cases+effective number of cases）∕ total inspection case load × 100%.
1.5 treatment results
Treatment results are as shown in table 1：
Table 1：Lesions of liver and kidney patient treatment outcome caused by taking 30-72 year chemotherapy of product of the present invention
Therapeutic effect：Cure 66（55%）, effective 32（26.7%）, effective 20（16.7%）；Invalid 2
（1.7%）, total effective rate 98.3%.Positive effect is better than control group.
The present invention selection Radix Astragali, reed rhizome, coix seed, pilose antler, salvia chinensis, jatamans valeriana rhizome, oldenlandia diffusa, radix glycyrrhizae, dog testes and penis, Pueraria lobota
Totally 14 taste Chinese herbal medicines are combined by root, Semen Cuscutae, trichosanthes seed, Bai Bei and Ka Mi.Fang Zhong, jatamans valeriana rhizome have qi-regulating with, cold dispelling
Dehumidifying, the effect of activating blood circulation and reducing swelling；White shellfish reducing fever and causing diuresis, removing nebula；Block close with strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood
Effect；Pilose antler kidney-Yang invigorating, fills blood, benefiting quintessence, strengthening the bones and muscles；Salvia chinensis controls dysphagic, asthma due to excessive phlegm, hepatitis；Oldenlandia diffusa has heat-clearing,
Dampness removing, the effect of removing toxic substances；Dog testes and penis has the effect of warming kidney and enhancing body, strengthening and nourishing marrow and essence；Radix glycyrrhizae is invigorated the spleen and benefited qi, clearing heat and detoxicating, and eliminating the phlegm stops
Cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.Complete square compatibility 5, nourishing hepatic yin, nourishing qi and blood are played altogether, help sharing for kidney yang.Treated for two weeks
Phase, treatment group is efficient up to 98.3%, and control group is only 76.6%.
It should be pointed out that embodiment is the more representational example of the present invention, it is clear that skill of the invention
Art scheme is not limited to above-described embodiment, can also there is many variations.One of ordinary skill in the art, it is clearly public with institute of the invention
Written description open or according to file is undoubted to be obtained, and is considered as this patent scope of the claimed.
Claims (9)
1. the medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy, it is characterised in that be prepared by following bulk drugs,
For parts by weight：Radix Astragali 12-18；Reed rhizome 12-18；Coix seed 11-13；Pilose antler 6-9；Salvia chinensis 10-11；Jatamans valeriana rhizome 11-13；White flower
HERBA HEDYOTIS DIFFUSAE 7-9；Radix glycyrrhizae 11-14；Dog testes and penis 16-19；Root of kudzu vine 12-14；Semen Cuscutae 7-9；Trichosanthes seed 7-9；White shellfish 11-13；Block close 13-
15。
2. the medicament of the damage side reaction of hepatic and renal function caused by mitigating chemotherapy as claimed in claim 1, it is characterised in that by following
Bulk drug is prepared, and is parts by weight：The Radix Astragali 15；Reed rhizome 15；Coix seed 12；Pilose antler 7.5；Salvia chinensis 10.5；Jatamans valeriana rhizome 12；
Oldenlandia diffusa 8；Radix glycyrrhizae 12.5；Dog testes and penis 17.5；The root of kudzu vine 13；Semen Cuscutae 8；Trichosanthes seed 8；White shellfish 12；Block close 14.
3. the medicament of the damage side reaction of hepatic and renal function caused by the mitigation chemotherapy as described in claim 1-2 is any, it is characterised in that
Pharmaceutically acceptable decoction is made into, preparation method is as follows：
（1）To block it is close clean, put in heat container, heated with moderate heat, fry to medical surfaces and add in sallow or burnt brown, internal color
Deeply, and when having burnt odor gas stop, grinding, it is standby；White shellfish is cleaned, and is placed in container, heats with high heat, it is in burnt brown to roast to surface
When stop, smashing to pieces, pulverization is standby；
（2）Take piece of antler to put on slow fire to warm, put into yellow rice wine and quench, dry after quenching, be sucked to yellow rice wine again, then burnt to sallow
Color, side plays vesicle and has crisp fragrance, dries in the air cool, be ground into fine powder, standby；Coix seed is placed in pulverizer, is ground into smalls, standby；
（3）By step（1）And step（2）Gained fine powder mixes, and crosses 90-130 mesh sieves, obtains mixing fine powders；
（4）Jatamans valeriana rhizome is cleaned, and section, is placed in white wine and is soaked 35 minutes, is taken out, with the Radix Astragali, reed rhizome, salvia chinensis, oldenlandia
Grass, radix glycyrrhizae, dog testes and penis, the root of kudzu vine, Semen Cuscutae and trichosanthes seed are together placed in marmite, add the distilled water of 5-9 times of medicinal material amount at 35 DEG C
Immersion 3 hours, is boiled by intense fire, is turned to be cooked by slow fire 3 hours, is filtered, obtain decocting liquid；
（5）Step is added into above-mentioned decocting liquid（3）Gained mixing fine powders, continue heating and decoct 20-40 minutes, filtering, sterilize 12-
24 minutes, the temperature of sterilizing was 95-115 DEG C, encapsulation, is produced.
4. the preparation method of decoction as claimed in claim 3, it is characterised in that step（3）Cross 100-120 mesh sieves.
5. the preparation method of decoction as claimed in claim 3, it is characterised in that step（5）The temperature of sterilizing is 100-110 DEG C.
6. the medicament of the damage side reaction of hepatic and renal function caused by the mitigation chemotherapy as described in claim 1-2 is any, it is characterised in that
Pharmaceutically acceptable pill is made into, preparation method is as follows：
（1）Reed rhizome is put into pot after cleaning, and adds the clear water of 3.5 times of amounts, and big fire decocts 18 minutes, filter cleaner, and taking juice is standby
With；
（2）White shellfish, Ka Mi and pilose antler, are placed in hot pot, intense fire heating, roast and stop when being in burnt brown to surface, smash to pieces, are ground into thin
End, 120-160 mesh sieves are crossed, it is standby to obtain mixing fine powders；Coix seed is placed in pulverizer, is ground into smalls, standby；
（3）Jatamans valeriana rhizome, Semen Cuscutae and trichosanthes seed are cleaned respectively, are placed in extractor, adds the ethanol that mass fraction is 80%,
After impregnating 30 minutes, twice, extraction 2 hours, second of extraction 1.8 hours, each ethanol add heating and refluxing extraction for the first time
Enter 5-8 times that amount is medicinal material amount, merge alcohol extract, ethanol is recovered under reduced pressure, relative density is 1.30-1.33 when being concentrated into 65 DEG C
Thick paste 1；
（4）By step（2）Gained coix seed powder is together placed in the Radix Astragali, salvia chinensis, oldenlandia diffusa, radix glycyrrhizae, dog testes and penis and the root of kudzu vine
In non iron container, the pure water for adding 7.5 times of amounts soaks 2.2 hours, changes after boiling by intense fire and is cooked by slow fire twice, decocts for the first time
Boil 90 minutes, second of decoction 45 minutes, filtering, merge decocting liquid twice, add step（1）Gained juice, mixing, is concentrated under reduced pressure
Into paste, thick paste 2 is obtained；
（5）By step（3）Gained thick paste 1 and step（4）Gained thick paste 2 mixes, and adds step（2）Gained mixing fine powders, stirring
Uniformly, pill is processed into, is produced.
7. the preparation method of pill as claimed in claim 6, it is characterised in that step（2）Cross 130-150 mesh sieves.
8. the medicament of the damage side reaction of hepatic and renal function caused by the mitigation chemotherapy as described in claim 1-2 is any, it is characterised in that
Pharmaceutically acceptable tablet is made into, preparation method is as follows：
（1）Take honey to add water-solubleization, pour into piece of antler, mix thoroughly, taken out after exhausting, put and 1-3 hours are steamed in food steamer, take out
Dry, grind standby；White shellfish, block close, Semen Cuscutae and trichosanthes seed, be placed in hot pot, intense fire heating, roast to surface be in burnt brown when
Stop, smashing to pieces, pulverization is standby；Coix seed is placed in pulverizer, is ground into smalls, standby；
（2）Jatamans valeriana rhizome, oldenlandia diffusa, the Radix Astragali, salvia chinensis, reed rhizome, radix glycyrrhizae, the root of kudzu vine and dog testes and penis are together placed in marmite, are added
The 5-7 times of pure water measured soaks 1.5 hours, changes after boiling by intense fire and is cooked by slow fire twice, decocts for the first time 45-65 minutes, second
Secondary decoction 25-45 minutes, filtering, merge decocting liquid twice, it is the clear of 1.30-1.35 that decocting liquid, which continues to be concentrated into 75 DEG C of relative densities,
Cream, spray drying, obtains dry extract；
（3）By step（1）Gained fine medicinal material powder and step（2）Gained dry extract mixes, and stirs, and crosses 100 mesh sieves, to mixed
Close and hydroxypropyl methylcellulose, cornstarch and dextrin, medicinal powder are added in fine powder:Hydroxypropyl methylcellulose:Cornstarch:Dextrin is 10:
1.1:1:0.7, tablet is made, produces.
9. the medicament of the damage side reaction of hepatic and renal function caused by the mitigation chemotherapy as described in claim 1-2 is any, it is characterised in that
Pharmaceutically acceptable thick paste agent is made into, preparation method is as follows：
（1）Net licorice tablet is taken, the refined honey diluted with boiling water pours leaching, mixes thoroughly, vexed profit, puts in frying container, slow fire heating, fries extremely
Strong yellow, when tack-free, taking-up cools；
（2）Take honey to add water-solubleization, pour into piece of antler, mix thoroughly, taken out after exhausting, put and 1-3 hours are steamed in food steamer, take out
Dry, grind standby；White shellfish, block close, Semen Cuscutae and trichosanthes seed, be placed in hot pot, intense fire heating, roast to surface be in burnt brown when
Stop, smashing to pieces, cross 120 mesh sieves, pulverization is standby；Coix seed is placed in pulverizer, is ground into smalls, standby；
（3）By step（1）Licorice tablet and jatamans valeriana rhizome, oldenlandia diffusa, the Radix Astragali, salvia chinensis, reed rhizome, the root of kudzu vine and dog testes and penis after processing
Together it is placed in marmite, the pure water for adding 6 times of amounts soaks 1.5 hours in 40 DEG C, changes after boiling by intense fire and is cooked by slow fire twice, the
Once decoct 65 minutes, second of decoction 35 minutes, filtering, merge decocting liquid twice；
（4）Step is added into above-mentioned decocting liquid（2）Gained fine powder, paste is concentrated under reduced pressure into, cools down, dry sterilization, produce.
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| CN102284049A (en) * | 2011-08-17 | 2011-12-21 | 沈阳药科大学 | Traditional Chinese medicine compound preparation for resisting ulcer and relieving chemoradiotherapeutic toxic and side effects, and preparation method and application thereof |
| CN102327390A (en) * | 2011-10-18 | 2012-01-25 | 周国生 | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills |
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| CN102284049A (en) * | 2011-08-17 | 2011-12-21 | 沈阳药科大学 | Traditional Chinese medicine compound preparation for resisting ulcer and relieving chemoradiotherapeutic toxic and side effects, and preparation method and application thereof |
| CN102327390A (en) * | 2011-10-18 | 2012-01-25 | 周国生 | Formula for Chinese medicine for preventing and treating chemotherapeutic toxic and side reaction and preparation method for Chinese medicinal pills |
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| Title |
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| 化疗毒副反应的中医治疗浅议;钟琼仙;《云南中医中药杂志》;20071231;第28卷(第6期);60 * |
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