CN101278996A - Medicament compound for curing sciatica and method of preparing the same - Google Patents
Medicament compound for curing sciatica and method of preparing the same Download PDFInfo
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- CN101278996A CN101278996A CNA2008101037671A CN200810103767A CN101278996A CN 101278996 A CN101278996 A CN 101278996A CN A2008101037671 A CNA2008101037671 A CN A2008101037671A CN 200810103767 A CN200810103767 A CN 200810103767A CN 101278996 A CN101278996 A CN 101278996A
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Abstract
The invention discloses a pharmaceutical composition for treating sciatica. The effective components of the invention comprise more than a dozen of medicinal materials including Chinese angelica, radix astragali, salvia miltiorrhiza, frankincense, myrrh, Eucommia, radix dipsaci from Sichuan, Achyranthes Bidentata, Chinese pawpaw, rhizoma atractylodis sinensis, asarum, fumitory and licorice, etc. The specific medicinal materials in the invention have the functions of activating blood circulation to dissipate blood stasis, alleviating pain, and relieving rheumatism and coldness and are used for patients with the sciatic with the symptoms of waist and leg pain, numbing in legs, getting cold, intolerance against coldness and thermophily property.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen for the treatment of sciatica and preparation method thereof.
Technical background
Sciatica is meant the pain that takes place along sciatic nerve path and areal area thereof, i.e. the pain in the outside and the foot outside behind buttocks, thigh rear side, the shank.It is acute or subacute that onset mostly is.It can be an independent disease, i.e. sciatic neuritis, and be to be secondary to other in most cases
DiseaseA syndrome.
The cause of disease of sciatica can be divided into constitutional and Secondary cases (symptomatic) two big classes.Primary sciatica is a sciatic neuritis, and is rare clinically, mainly is sciatic matter inflammation, how by focal infections such as tooth, paranasal sinus, tonsils, invade through blood and neural coat causes, many and myositis and fibrositis happen in company with, cold, moist normal be risk factor.The Secondary cases sciatica is more common clinically, suffers in the sciatic nerve path mainly that the adjacent tissue pathological changes stimulates, compressing or cause because of systemic disease (as diabetes, gout etc.).The common cause of disease has: 1. spine disorders: go out as lumbar intervertebral disc prominent (taking off), lumbosacral region birth defects (as spina bifida, lumbar spinal stenosis, lumbar sacralization, the long deformity of the 3rd transverse process of lumbar vertebra, spondylolysis and spondylolysis etc.) also has tuberculosis of spine, spondylitis etc. in addition; 2. illness in the canalis spinalis: as the inflammation of spinal cord and horse hair, tumor, wound, blood vessel deformity, arachnoid adhesion etc.; 3. pelvis illness: as sciatic nerve pelvic cavity outlet contraction, piriformis pathological changes, sacroiliitis, sacroiliac disease, subluxation of sacroiliac joint, coxitis etc.; 4. pelvic cavity illness: as chronic pelvic inflammatory disease, adnexitis, tumor, lymphatic metastasis cancer etc.; 5. buttocks
MedicineThe position of injection is improper, and the sciatic nerve due to the traumatic hematoma holds disease; 6. the dysbolismus of poisoning is as diabetes etc.
Sciatica belongs to muscular rheumatism category in the traditional Chinese medical science arthromyodynia, endogenous cause of ill caused by liver and kidney deficiency, exopathogenic factor wind-cold damp pathogen invasion and attack lower limb meridians, impatency passages through which vital energy circulates, so that stagnation of QI-blood, stagnation of QI and blood may bring about pain.
The present invention defers to the differential diagnosis in tcm opinion and controls and prescription, and Radix Angelicae Sinensis, the Radix Astragali, Radix Salviae Miltiorrhizae activating blood circulation to dissipate blood stasis and dredge the collateral stagnate to control the stasis of blood in the side; Olibanum, the pain relieving of Myrrha promoting flow of QI and blood; Rhizoma Atractylodis, Herba Asari, Rhizoma Corydalis expelling wind and removing dampness cold expelling; The Cortex Eucommiae, Radix Dipsaci, Radix Cyathulae, Fructus Chaenomelis liver and kidney tonifying, the relaxing muscles and tendons and activating QI and blood in the collateral priming is descending, through sick institute; The Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Close and use it, make heresy remove eutopic reduction, QI and blood, meridians are unimpeded, and pain is only recovered.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen for the treatment of sciatica.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Angelicae Sinensis 100-300 part Radix Astragali 100-300 part Radix Salviae Miltiorrhizae 100-300 part
Olibanum 50-150 part Myrrha 50-150 part Cortex Eucommiae 50-150 part
Radix Dipsaci 50-150 part Radix Cyathulae 50-150 part Fructus Chaenomelis 100-300 part
Rhizoma Atractylodis 50-150 part Herba Asari 100-300 part Rhizoma Corydalis 100-300 part
Radix Glycyrrhizae 50-150 part
The active component that preferred following raw materials according is made, curative effect is better:
200 parts of 150 parts of Radix Salviae Miltiorrhizaes of 200 parts of Radixs Astragali of Radix Angelicae Sinensis
100 parts of 100 parts of Cortexs Eucommiae of 100 parts of Myrrhas of Olibanum
150 parts of 100 portions of Fructus Chaenomeliss of 100 portions of Radix Cyathulaes of Radix Dipsaci
200 parts of 150 parts of Rhizoma Corydalis of 100 parts of Herba Asaris of Rhizoma Atractylodis
100 parts in Radix Glycyrrhizae
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Rhizoma Corydalis, the Radix Astragali, Radix Salviae Miltiorrhizae add 80% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Angelicae Sinensis, Olibanum, Myrrha, the Cortex Eucommiae, Radix Dipsaci, Radix Cyathulae, Fructus Chaenomelis, Rhizoma Atractylodis, Herba Asari, Radix Glycyrrhizae and decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, expelling wind and cold, is used for lumbago and skelalgia, companion's shank numbness, cool, a fear of cold happiness temperature, and sciatica is seen above-mentioned patient.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
200 parts of 150 parts of Radix Salviae Miltiorrhizaes of 200 parts of Radixs Astragali of Radix Angelicae Sinensis
100 parts of 100 parts of Cortexs Eucommiae of 100 parts of Myrrhas of Olibanum
150 parts of 100 portions of Fructus Chaenomeliss of 100 portions of Radix Cyathulaes of Radix Dipsaci
200 parts of 150 parts of Rhizoma Corydalis of 100 parts of Herba Asaris of Rhizoma Atractylodis
100 parts in Radix Glycyrrhizae
2. preparation technology
(1) Rhizoma Corydalis, the Radix Astragali, Radix Salviae Miltiorrhizae add 80% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Angelicae Sinensis, Olibanum, Myrrha, the Cortex Eucommiae, Radix Dipsaci, Radix Cyathulae, Fructus Chaenomelis, Rhizoma Atractylodis, Herba Asari, Radix Glycyrrhizae and decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds cane sugar powder, and mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
200 parts of 150 parts of Radix Salviae Miltiorrhizaes of 200 parts of Radixs Astragali of Radix Angelicae Sinensis
100 parts of 100 parts of Cortexs Eucommiae of 100 parts of Myrrhas of Olibanum
150 parts of 100 portions of Fructus Chaenomeliss of 100 portions of Radix Cyathulaes of Radix Dipsaci
200 parts of 150 parts of Rhizoma Corydalis of 100 parts of Herba Asaris of Rhizoma Atractylodis
100 parts in Radix Glycyrrhizae
2. preparation technology
(1) Rhizoma Corydalis, the Radix Astragali, Radix Salviae Miltiorrhizae add 80% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Angelicae Sinensis, Olibanum, Myrrha, the Cortex Eucommiae, Radix Dipsaci, Radix Cyathulae, Fructus Chaenomelis, Rhizoma Atractylodis, Herba Asari, Radix Glycyrrhizae and decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
200 parts of 150 parts of Radix Salviae Miltiorrhizaes of 200 parts of Radixs Astragali of Radix Angelicae Sinensis
100 parts of 100 parts of Cortexs Eucommiae of 100 parts of Myrrhas of Olibanum
150 parts of 100 portions of Fructus Chaenomeliss of 100 portions of Radix Cyathulaes of Radix Dipsaci
200 parts of 150 parts of Rhizoma Corydalis of 100 parts of Herba Asaris of Rhizoma Atractylodis
100 parts in Radix Glycyrrhizae
2. preparation technology
(1) Rhizoma Corydalis, the Radix Astragali, Radix Salviae Miltiorrhizae add 80% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Angelicae Sinensis, Olibanum, Myrrha, the Cortex Eucommiae, Radix Dipsaci, Radix Cyathulae, Fructus Chaenomelis, Rhizoma Atractylodis, Herba Asari, Radix Glycyrrhizae and decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, sieves, and adds starch, and mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen for the treatment of sciatica is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier,
Wherein said active ingredient is made by following raw materials according:
Radix Angelicae Sinensis 100-300 part Radix Astragali 100-300 part Radix Salviae Miltiorrhizae 100-300 part
Olibanum 50-150 part Myrrha 50-150 part Cortex Eucommiae 50-150 part
Radix Dipsaci 50-150 part Radix Cyathulae 50-150 part Fructus Chaenomelis 100-300 part
Rhizoma Atractylodis 50-150 part Herba Asari 100-300 part Rhizoma Corydalis 100-300 part
Radix Glycyrrhizae 50-150 part.
2, a kind of drug regimen for the treatment of sciatica according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
200 parts of 150 parts of Radix Salviae Miltiorrhizaes of 200 parts of Radixs Astragali of Radix Angelicae Sinensis
100 parts of 100 parts of Cortexs Eucommiae of 100 parts of Myrrhas of Olibanum
150 parts of 100 portions of Fructus Chaenomeliss of 100 portions of Radix Cyathulaes of Radix Dipsaci
200 parts of 150 parts of Rhizoma Corydalis of 100 parts of Herba Asaris of Rhizoma Atractylodis
100 parts in Radix Glycyrrhizae.
3, according to the described a kind of drug regimen for the treatment of sciatica of claim 1-2, it is characterized in that adopting following method to make:
(1) Rhizoma Corydalis, the Radix Astragali, Radix Salviae Miltiorrhizae add 80% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Angelicae Sinensis, Olibanum, Myrrha, the Cortex Eucommiae, Radix Dipsaci, Radix Cyathulae, Fructus Chaenomelis, Rhizoma Atractylodis, Herba Asari, Radix Glycyrrhizae and decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as granule, sheet, capsule.
4, according to any one described a kind of drug regimen for the treatment of sciatica among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen for the treatment of sciatica of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101037671A CN101278996A (en) | 2008-04-10 | 2008-04-10 | Medicament compound for curing sciatica and method of preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101037671A CN101278996A (en) | 2008-04-10 | 2008-04-10 | Medicament compound for curing sciatica and method of preparing the same |
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| Publication Number | Publication Date |
|---|---|
| CN101278996A true CN101278996A (en) | 2008-10-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101037671A Pending CN101278996A (en) | 2008-04-10 | 2008-04-10 | Medicament compound for curing sciatica and method of preparing the same |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188672A (en) * | 2010-03-09 | 2011-09-21 | 王贻涛 | Plaster capable of treating pain from shoulders, neck, waist and legs |
| CN102784258A (en) * | 2012-08-09 | 2012-11-21 | 宋健 | Medicament for treating primary sciatica |
| CN106074660A (en) * | 2016-08-11 | 2016-11-09 | 南京中医药大学 | Olibanum and Myrrha application in preparation preventing and treating neuropathic pain disease medicament |
| CN108310264A (en) * | 2018-03-09 | 2018-07-24 | 李文本 | A kind of Chinese medicine composition for treating protrusion of lumber intervertebral disc sciatic nerve crush |
-
2008
- 2008-04-10 CN CNA2008101037671A patent/CN101278996A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188672A (en) * | 2010-03-09 | 2011-09-21 | 王贻涛 | Plaster capable of treating pain from shoulders, neck, waist and legs |
| CN102784258A (en) * | 2012-08-09 | 2012-11-21 | 宋健 | Medicament for treating primary sciatica |
| CN106074660A (en) * | 2016-08-11 | 2016-11-09 | 南京中医药大学 | Olibanum and Myrrha application in preparation preventing and treating neuropathic pain disease medicament |
| CN108310264A (en) * | 2018-03-09 | 2018-07-24 | 李文本 | A kind of Chinese medicine composition for treating protrusion of lumber intervertebral disc sciatic nerve crush |
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Open date: 20081008 |