CN113318147A - Formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain - Google Patents

Formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain Download PDF

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CN113318147A
CN113318147A CN202110651006.5A CN202110651006A CN113318147A CN 113318147 A CN113318147 A CN 113318147A CN 202110651006 A CN202110651006 A CN 202110651006A CN 113318147 A CN113318147 A CN 113318147A
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parts
formula
relieving pain
eliminating dampness
activating collaterals
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马傲云
王建华
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Qiaofusheng Pharmaceutical Co ltd
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Qiaofusheng Pharmaceutical Co ltd
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain. Aims to solve the technical problem that the existing method for treating the vein blocking tendon injury is limited. The formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain is prepared from the following raw materials in parts by weight: 55-70 parts of water, 9-10 parts of glycerol, 8-10 parts of propylene glycol, 0.8-1 part of argyi leaf oil, 0.5-0.65 part of mint, 0.8-1 part of carbomer, 0.6-0.65 part of xanthan gum, 2-4 parts of notopterygium root extract, 2-5 parts of radix angelicae pubescentis extract, 3-8 parts of radix linderae extract, 0.3-0.35 part of methyl hydroxybenzoate, 0.3-0.35 part of hydroxy phenylpropyl ester and 1-1.2 parts of sodium polyacrylate. The invention also provides a preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain. The formula for relaxing muscles and tendons, activating collaterals, eliminating dampness and relieving pain has the effects of promoting blood circulation, calming the wind and dredging collaterals; the paste is fine and smooth, and has good pain relieving effect and quick response; has the function of harmonizing the vein, blocking the tendon and injury.

Description

Formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain
Technical Field
The invention relates to the technical field of medicine preparation, and particularly relates to a formula for relaxing tendons, activating collaterals, clearing damp and relieving pain.
Background
Osteoarticular ligament tendon injury is the most common disease in traumatology. In clinical treatment, the traditional Chinese medicine is called as 'tendon injury' regardless of ligament injury, tendon injury or simultaneous injury. Actually, the injury of meridians and tendons means that blood at the injured part overflows into the skin when the meridians and tendons are injured, the blood stasis cannot be dissipated, the activities of meridians and collaterals are blocked, and qi stagnation and blood stasis cause that the injured tendons cannot be nourished by qi and blood, so that symptoms such as swelling and pain, difficulty in stretching and bending of joints or weakness or instability are presented. The Su Wen & Miao Lun recorded: "people fall down to some extent and have some blood in them. "Lingshu & Benzang" (book of books records): blood harmonizing with blood leads to the circulation of meridians, restoring yin and yang, strengthening tendons and bones, and smoothing joints. "
At present, western medicines are usually selected for quick treatment, but are strong in western medicine dependence and chemical substances, and further comprise various auxiliary materials, so that the side effect is large, new diseases can be caused, radical treatment cannot be achieved, and only a relieving effect can be achieved.
Disclosure of Invention
The invention aims to provide a formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain. So as to solve the limited technical problem of the existing method for treating the vein blocking tendon injury.
In order to solve the technical problems, the invention adopts the following technical scheme:
the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain is provided, and is prepared from the following raw materials in parts by weight:
55-70 parts of water, 9-10 parts of glycerol, 8-10 parts of propylene glycol, 0.8-1 part of argyi leaf oil, 0.5-0.65 part of mint, 0.8-1 part of carbomer, 0.6-0.65 part of xanthan gum, 2-4 parts of notopterygium root extract, 2-5 parts of radix angelicae pubescentis extract, 3-8 parts of radix linderae extract, 0.3-0.35 part of methyl hydroxybenzoate, 0.3-0.35 part of hydroxy phenylpropyl ester and 1-1.2 parts of sodium polyacrylate.
Preferably, the mint is ground and then sieved by a sieve of 20-30 meshes to prepare mint powder.
Preferably, the preparation method of the extract comprises the following steps:
respectively taking notopterygium root, radix angelicae pubescentis and combined spicebush root, smashing, sieving by a 30-40-mesh sieve, respectively taking the sieved powder according to a material-liquid ratio of 1: adding 75% ethanol into the mixture 8-10, heating and refluxing for extraction, distilling the obtained extract under reduced pressure, recovering ethanol, concentrating, and performing spray drying to obtain a powdery extract.
Further, the temperature of the reflux extraction is controlled to be 85-90 ℃, and the time is controlled to be 2-2.5 hours.
In addition, the preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain comprises the following steps:
(1) drying the mint, crushing and sieving to obtain mint powder for later use;
(2) respectively taking the notopterygium root, the radix angelicae pubescentis and the combined spicebush root, smashing, sieving, and respectively taking the sieved powder according to the material-liquid ratio of 1: adding 75% ethanol into the mixture 8-10, heating and refluxing for extraction, distilling the obtained extract under reduced pressure, recovering ethanol, concentrating, and performing spray drying to obtain a powdery extract;
(3) and (3) adding distilled water into the mint powder obtained in the step (1), glycerol, propylene glycol, blumea oil, carbomer, xanthan gum, methyl hydroxybenzoate, propyl hydroxybenzoate, sodium polyacrylate and the powdery extract obtained in the step (2), mixing, and uniformly stirring to obtain the composition.
Preferably, in the step (1), a 20-30 mesh sieve is adopted during sieving.
Preferably, in the step (2), a 30-40 mesh sieve is adopted during sieving.
Preferably, in the step (2), the temperature of the reflux extraction is controlled to be 85-90 ℃, and the time is controlled to be 2-2.5 hours.
Compared with the prior art, the invention has the beneficial technical effects that:
the product of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain has the effects of activating blood circulation, calming wind and dredging collaterals; the paste is fine and smooth, and has good pain relieving effect and quick response; has effects of regulating meridians and tendons injury (such as arthralgia, soreness of waist and knees).
Detailed Description
The following examples and clinical examples are given to illustrate specific embodiments of the present invention, but the following examples are only intended to illustrate the present invention in detail and do not limit the scope of the present invention in any way.
The apparatus and devices referred to in the following examples and clinical examples are conventional apparatus and devices unless otherwise specified; the raw materials referred to in the following examples and clinical examples are commercially acceptable. Experimental procedures, for which specific conditions are not specified, are generally as routinely required.
Example 1: formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain
The formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain comprises the following components in percentage by mass:
70% of water, 10% of glycerol, 8% of propylene glycol, 1% of argyi leaf oil, 0.5% of mint, 1% of carbomer, 0.6% of xanthan gum, 2% of notopterygium root extract, 2% of radix angelicae pubescentis extract, 3% of radix linderae extract, 0.35% of methylparaben, 0.35% of propylparaben and 1.2% of sodium polyacrylate.
Wherein the Notopterygii rhizoma is Notopterygii rhizoma of UmbelliferaeNotopterygium incisum Ting ex H.T.ChangOr leaf of Notopterygium forbesiiNotopterygium, franchetii H. de Boiss.Dried rhizomes and roots of (1). Pungent, bitter and warm in nature; entering bladder and kidney meridians; has the main functions of relieving exterior syndrome, dispelling cold, expelling wind, eliminating dampness and relieving pain. Radix Angelicae Pubescentis is Angelica gigas nakai of UmbelliferaeAngelica pubecensDried root of (4). Bitter, pungent and warm in nature; entering kidney and bladder meridians; mainly used for dispelling wind-damp, relieving pain and relieving exterior syndrome. Radix Linderae is radix Linderae of LauraceaeLindera aggregata( Sims) KostermDried root tubers of (1). Pungent and warm. It enters lung, spleen, kidney and bladder meridians. Move qi and alleviate pain, warm kidney and dispel cold. Can be used for treating cold accumulation, qi stagnation, chest and abdomen distention and pain, asthma, bladder deficiency cold, enuresis, pollakisuria, hernia pain, and cold abdominal pain.
The preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain comprises the following steps:
(1) drying herba Menthae, pulverizing with a traditional Chinese medicine pulverizer, and sieving with a 30 mesh sieve to obtain herba Menthae powder;
(2) respectively taking notopterygium root, radix angelicae pubescentis and combined spicebush root, smashing the notopterygium root, radix angelicae pubescentis and the combined spicebush root by a traditional Chinese medicine smashing machine, sieving by a 40-mesh sieve, respectively taking sieved powder according to a material-liquid ratio of 1: 8, adding 75% ethanol, heating and reflux-extracting at 90 deg.C for 2 hr, distilling the obtained extractive solution under reduced pressure, recovering ethanol, concentrating, and spray drying to obtain powder extract;
(3) and (3) adding distilled water into the mint powder obtained in the step (1), glycerol, propylene glycol, blumea oil, carbomer, xanthan gum, methyl hydroxybenzoate, propyl hydroxybenzoate, sodium polyacrylate and the powdery extract obtained in the step (2), mixing, and uniformly stirring to obtain the skin antibacterial cream product.
Example 2: formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain
The formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain comprises the following components in percentage by mass:
59.5% of water, 9% of glycerol, 10% of propylene glycol, 0.8% of argyi leaf oil, 0.65% of mint, 0.8% of carbomer, 0.65% of xanthan gum, 4% of notopterygium root extract, 5% of radix angelicae pubescentis extract, 8% of radix linderae extract, 0.3% of methylparaben, 0.3% of propylparaben and 1% of sodium polyacrylate.
The preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain comprises the following steps:
(1) drying herba Menthae, pulverizing with a traditional Chinese medicine pulverizer, and sieving with a 20 mesh sieve to obtain herba Menthae powder;
(2) respectively taking notopterygium root, radix angelicae pubescentis and combined spicebush root, smashing the notopterygium root, radix angelicae pubescentis and the combined spicebush root by a traditional Chinese medicine smashing machine, sieving by a 30-mesh sieve, and respectively taking sieved powder according to a material-liquid ratio of 1: 10 adding 75% ethanol, heating and reflux-extracting at 85 deg.C for 2.5 hr, distilling the obtained extractive solution under reduced pressure, recovering ethanol, concentrating, and spray drying to obtain powder extract;
(3) and (3) adding distilled water into the mint powder obtained in the step (1), glycerol, propylene glycol, blumea oil, carbomer, xanthan gum, methyl hydroxybenzoate, propyl hydroxybenzoate, sodium polyacrylate and the powdery extract obtained in the step (2), mixing, and uniformly stirring to obtain the skin antibacterial cream product.
The use method of the formula product for relaxing tendons, activating collaterals, eliminating dampness and relieving pain comprises the following steps: the ointment is externally applied to the affected part thickly and is applied once every 3 to 5 days. A treatment course lasts for 15 days.
Typical clinical example 1: examples of treating fracture injury
The patients: qinzhi, male, age 52; the main complaints are: pain at the affected part in the later stage of fracture and difficulty in joint movement; no related contraindications and signed informed consent. And (3) clinical diagnosis: in the later stage of fracture injury, the vicious circle is caused by qi stagnation and blood stasis, meridian obstruction, unsmooth circulation of qi, blood and body fluids, stasis generation and phlegm generation to form a pathological product, phlegm and blood stasis are mixed and blocked, and meridian obstruction is aggravated.
Adopts a formula product for relaxing tendons, activating collaterals, eliminating dampness and relieving pain. The method comprises the following specific steps: after the affected part is cleaned, the paste is thickly applied to the affected part and continuously absorbed by the skin to dissolve and remove the stasis phlegm and dredge the channels and collaterals, thereby achieving the effect.
The treatment results are as follows: the pain is slightly relieved after the thick coating is firstly carried out for 5 days, and the pain is obviously relieved after one treatment course.
Clinical example 2: examples of treating chronic pain
The patients: zhangyi, female, age 45; the main complaints are: pain and swelling of the lower limbs remain for more than two years. No related contraindications and signed informed consent. And (3) clinical diagnosis: long-term load bearing work is done to make chronic pain of lower limbs and little dysfunction.
Adopts a formula product for relaxing tendons, activating collaterals, eliminating dampness and relieving pain. The method comprises the following specific steps: after the affected part is cleaned, the paste is thickly applied to the affected part and continuously absorbed by the skin to dissolve and remove the stasis phlegm and dredge the channels and collaterals, thereby achieving the effect.
The treatment results are as follows: the formula product for relaxing tendons, activating collaterals, eliminating dampness and relieving pain is taken and coated on the pain part thickly, and the thick coating is carried out again after 3 days. Proper auxiliary hot compress and massage can avoid long-time strenuous exercise during the treatment period. Pain and swelling are obviously relieved after four treatment courses, and lower limb functions are improved after six treatment courses.
While the present invention has been described in detail with reference to the embodiments and the clinical examples, those skilled in the art will appreciate that various changes can be made in the specific parameters of the embodiments without departing from the spirit of the invention, and that various specific embodiments are formed, which are common variations of the present invention and will not be described in detail herein.

Claims (8)

1. The formula for relaxing tendons, activating collaterals, clearing damp and relieving pain is characterized by being prepared from the following raw materials in parts by weight:
55-70 parts of water, 9-10 parts of glycerol, 8-10 parts of propylene glycol, 0.8-1 part of argyi leaf oil, 0.5-0.65 part of mint, 0.8-1 part of carbomer, 0.6-0.65 part of xanthan gum, 2-4 parts of notopterygium root extract, 2-5 parts of radix angelicae pubescentis extract, 3-8 parts of radix linderae extract, 0.3-0.35 part of methyl hydroxybenzoate, 0.3-0.35 part of hydroxy phenylpropyl ester and 1-1.2 parts of sodium polyacrylate.
2. The formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain according to claim 1, wherein the mint is crushed and then sieved by a 20-30-mesh sieve to prepare mint powder.
3. The formulation for relaxing tendons, activating collaterals, eliminating dampness and relieving pain according to claim 1, wherein the preparation method of the extract comprises the following steps:
respectively taking notopterygium root, radix angelicae pubescentis and combined spicebush root, smashing, sieving by a 30-40-mesh sieve, respectively taking the sieved powder according to a material-liquid ratio of 1: adding 75% ethanol into the mixture 8-10, heating and refluxing for extraction, distilling the obtained extract under reduced pressure, recovering ethanol, concentrating, and performing spray drying to obtain a powdery extract.
4. The formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain according to claim 3, wherein the temperature of reflux extraction is controlled to be 85-90 ℃ and the time is controlled to be 2-2.5 hours.
5. The preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain according to claim 1 is characterized by comprising the following steps:
(1) drying the mint, crushing and sieving to obtain mint powder for later use;
(2) respectively taking the notopterygium root, the radix angelicae pubescentis and the combined spicebush root, smashing, sieving, and respectively taking the sieved powder according to the material-liquid ratio of 1: adding 75% ethanol into the mixture 8-10, heating and refluxing for extraction, distilling the obtained extract under reduced pressure, recovering ethanol, concentrating, and performing spray drying to obtain a powdery extract;
(3) and (3) adding distilled water into the mint powder obtained in the step (1), glycerol, propylene glycol, blumea oil, carbomer, xanthan gum, methyl hydroxybenzoate, propyl hydroxybenzoate, sodium polyacrylate and the powdery extract obtained in the step (2), mixing, and uniformly stirring to obtain the composition.
6. The preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain according to claim 5, wherein in the step (1), a sieve with 20-30 meshes is adopted during sieving.
7. The preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain according to claim 5, wherein in the step (2), a 30-40-mesh sieve is adopted during sieving.
8. The preparation method of the formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain according to claim 5, characterized in that in the step (2), the temperature of reflux extraction is controlled to be 85-90 ℃ and the time is controlled to be 2-2.5 hours.
CN202110651006.5A 2021-06-11 2021-06-11 Formula for relaxing tendons, activating collaterals, eliminating dampness and relieving pain Pending CN113318147A (en)

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CN114767822A (en) * 2022-04-13 2022-07-22 伊莎颜社(佛山市)商务服务有限公司 A Chinese medicinal bag for relieving inflammation and pain, and its preparation method

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Application publication date: 20210831