CN114767822A - A Chinese medicinal bag for relieving inflammation and pain, and its preparation method - Google Patents
A Chinese medicinal bag for relieving inflammation and pain, and its preparation method Download PDFInfo
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- CN114767822A CN114767822A CN202210385626.3A CN202210385626A CN114767822A CN 114767822 A CN114767822 A CN 114767822A CN 202210385626 A CN202210385626 A CN 202210385626A CN 114767822 A CN114767822 A CN 114767822A
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- traditional chinese
- chinese medicine
- powder
- pain
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Medical Informatics (AREA)
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- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The application provides a traditional Chinese medicine bag for diminishing inflammation and relieving pain and a preparation method thereof, and relates to the field of medical health products. A traditional Chinese medicine package for diminishing inflammation and easing pain comprises the following raw materials in parts by weight: 22-26 parts of vitex leaves, 22-26 parts of notopterygium roots, 15-20 parts of folium artemisiae argyi, 15-20 parts of safflower, 15-20 parts of radix angelicae pubescentis, 10-14 parts of rhizoma cyperi, 10-14 parts of caulis spatholobi, 6-9 parts of ginger and 6-9 parts of hydrogen-rich activation powder. According to the preparation method of the traditional Chinese medicine bag for diminishing inflammation and relieving pain, the extraction efficiency of the effective components in the raw materials is high, so that the treatment effect of the composition is good, and the drug effect can be exerted to the maximum. The application has reasonable medicine use, combines various medicines and has the effects of diminishing inflammation and easing pain.
Description
Technical Field
The application relates to the field of medical health-care products, in particular to a traditional Chinese medicine bag for diminishing inflammation and relieving pain and a preparation method thereof.
Background
Inflammation is what is commonly called "inflammation" and is a defense response of the body to stimuli, manifested by redness, swelling, heat, pain, and dysfunction. The inflammation may be infectious inflammation caused by infection or non-infectious inflammation not caused by infection. At present, the inflammation is clinically treated, and anti-inflammatory drugs are usually used for relieving the symptoms of the inflammation, but the anti-inflammatory drugs have toxic and side effects on cardiovascular diseases, gastrointestinal diseases, liver and kidney, and bring new threats to the life safety of patients. With the increase of the side effects of the medicines and the continuous emergence of the medicine-induced diseases, more and more people advocate the natural health care method.
The traditional Chinese medicine bath is to soak feet or bathe by adopting traditional Chinese medicine decoction, so that medicine ions quickly enter blood through skin mucous membrane absorption and warm fumigation of liquid medicine, are quickly distributed to the whole body along with blood circulation, directly act on an affected part without gastrointestinal damage, and play roles in dissipating heat and moisturizing, relaxing muscles and bones, regulating vital energy and regulating blood, thereby achieving a series of health-care effects of enhancing cardiovascular and cerebrovascular functions, improving sleep, eliminating fatigue, eliminating sub-health state, enhancing human body resistance and the like. Meanwhile, compared with the oral medicine, the intake of the medicine in the traditional Chinese medicine medicated bath has the advantages of quick curative effect, comfort, ease, convenience, no toxic or side effect and the like.
Disclosure of Invention
The application aims to provide an anti-inflammatory and analgesic traditional Chinese medicine bag which is reasonable in compatibility and has the effects of resisting inflammation, relieving pain, quickly diminishing inflammation, relieving heat and removing free radicals.
Another objective of the present application is to provide a method for preparing an anti-inflammatory and analgesic traditional Chinese medicine bag, which has the advantages of simple process, low raw material cost, maximized drug efficacy, etc.
The technical problem to be solved by the application is achieved by adopting the following technical scheme.
On one hand, the embodiment of the application provides an anti-inflammatory and analgesic traditional Chinese medicine package which comprises the following raw materials in parts by weight: 22-26 parts of vitex negundo leaf, 22-26 parts of notopterygium root, 15-20 parts of folium artemisiae argyi, 15-20 parts of safflower, 15-20 parts of radix angelicae pubescentis, 10-14 parts of rhizoma cyperi, 10-14 parts of caulis spatholobi, 6-9 parts of ginger and 6-9 parts of hydrogen-rich activation powder.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine package for diminishing inflammation and relieving pain, which comprises the following steps:
pretreatment of medicinal materials: removing impurities from folium Viticis Cannabifoliae, and parching; soaking Notopterygii rhizoma in 30-40 deg.C water; soaking folium Artemisiae Argyi, Carthami flos, radix Angelicae Pubescentis, rhizoma Cyperi, caulis Spatholobi and rhizoma Zingiberis recens in tap water, mixing all the above processed raw materials, pulverizing, and drying to obtain micropowder;
preparing an extract: adding the dried micro powder into an organic solvent, standing, performing microwave-assisted extraction to obtain an extracting solution, centrifuging the extracting solution, taking supernatant, adding ammonium sulfate, standing for layering, centrifuging the supernatant, taking supernatant to obtain an extract, and preparing the extract into the traditional Chinese medicine bag.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
the traditional Chinese medicine considers that the inflammation is a heat syndrome, which is caused by various factors such as external infection, internal injury and the like, and clinically has various syndromes such as exterior heat syndrome, interior excess heat syndrome, deficiency and excess mixed syndrome and the like. The traditional Chinese medicine is used for treating inflammatory diseases, not simply diminishing inflammation or simply clearing heat, but comprehensively treating by using various methods of relieving exterior syndrome, clearing heat, warming and activating, tonifying and the like on the basis of syndrome differentiation, so that the overall regulation is achieved. In the application, caryophyllene which is a main component of vitex leave volatile oil has the effects of eliminating phlegm, relieving asthma, improving organism immunity, resisting bacteria and diminishing inflammation, notopterygium root has the functions of dredging the limb, smoothing blood vessels, attacking pathogenic factors and dispersing wind-cold and rheumatism, and the notopterygium root volatile oil has the effects of relieving heat and resisting bacteria, has the effects of dredging channels, relieving heat syndrome and resisting bacteria and diminishing inflammation when being matched, and is a monarch drug; the folium artemisiae argyi, the safflower and the radix angelicae pubescentis are matched together to serve as ministerial drugs and assist monarch drugs to achieve better effects, wherein the volatile oil of the folium artemisiae argyi has the effect of killing or inhibiting various germs, the folium artemisiae argyi can dredge twelve meridians, particularly the drugs of liver, spleen and kidney, and is good at warming middle energizer, expelling cold and removing dampness, and moving qi in blood, the safflower can dredge meridians and collaterals, and is a qi-flowing drug in blood, can be used for purging and tonifying, and has miraculous meanings, the radix angelicae pubescentis is a main drug for dispelling wind and dredging collaterals, and has the effects of diminishing inflammation, relieving pain, tonifying middle energizer, benefiting qi and dredging channels and promoting blood circulation by matching, the rhizoma cyperi and the caulis spatholobi are also used as adjuvant drugs, wherein the rhizoma cyperi can be used for dispelling stasis and dispersing qi, the volatile oil of the rhizoma cyperi has the effects of relieving pain and resisting bacteria, the caulis spatholobi has the effects of replenishing blood, promoting blood circulation and dredging collaterals, the qi can be used for dispelling stagnation, and relieving pain and resisting bacteria, and finally the ginger is used as a messenger drug, the ginger is used for relieving exterior syndrome, dispelling cold, warming middle energizer and stopping vomiting, and all the medicines can be used for diminishing inflammation, relieving pain, and relieving pain, Tonify qi and blood, dredge meridians and collaterals, and reach focus of infection directly. In addition, the creation point of the application is that the hydrogen-rich activation powder in the compatibility of the traditional Chinese medicine composition contains hydrogen molecules and has strong permeability, so that the hydrogen-rich activation powder can enable components such as volatile oil in the vitex negundo leaves to better permeate into water, and the drug effect of the traditional Chinese medicine composition is better exerted. In the application, the hydrogen-rich activation powder is added into the traditional Chinese medicine bag, so that the medicine effect can be enhanced, the application is reasonable in medicine application, and the traditional Chinese medicine bag has the effects of relieving pain, diminishing inflammation, clearing heat and removing free radicals by combining various medicines.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that, in the present application, the embodiments and features of the embodiments may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
A traditional Chinese medicine bag for diminishing inflammation and easing pain comprises the following raw materials in parts by weight: 22-26 parts of vitex negundo leaf, 22-26 parts of notopterygium root, 15-20 parts of folium artemisiae argyi, 15-20 parts of safflower, 15-20 parts of radix angelicae pubescentis, 10-14 parts of rhizoma cyperi, 10-14 parts of caulis spatholobi, 6-9 parts of ginger and 6-9 parts of hydrogen-rich activation powder.
Vitex negundo L.leaves enter lung meridian, and their nature and taste are slightly bitter, pungent and mild. Has expectorant, antitussive, and antiasthmatic effects. Can be used for treating cough and asthma; chronic bronchitis.
The main component caryophyllene in the volatile oil in folium Viticis Cannabifoliae can increase serum IgG level, enhance humoral immunity, reduce phagocytic ability of reticuloendothelial system to carbon granules, and significantly improve phagocytic rate, phagocytic index and digestion degree of macrophage for chronic tracheitis patients with low phagocytic function of macrophage, so that it is close to normal level. The folium Viticis Cannabifoliae volatile oil can promote albumin to rise, has bidirectional regulation effect on gamma-, beta-and alpha-globulin, and can promote albumin synthesis and regulate immunoglobulin.
Notopterygium root, rhizoma Notopterygii, enters bladder and kidney meridians, and is pungent, bitter and warm in nature. Has effects in dispelling cold, dispelling pathogenic wind, removing dampness, and relieving pain. Can be used for treating wind-cold type common cold, headache, rheumatalgia, and soreness of shoulder and back.
Folium Artemisiae Argyi enters spleen, liver and kidney meridians, and is bitter and pungent in nature and warm in nature. Has effects in dispelling cold, relieving pain, warming channels, and stopping bleeding. Can be used for treating lower abdomen psychroalgia, menoxenia, infertility due to cold womb, hematemesis, epistaxis, metrorrhagia, metrostaxis, and pregnancy hemorrhage; it can be used for treating skin pruritus. Vinegar moxa charcoal can warm meridians and stop bleeding. Can be used for treating hemorrhage due to deficiency cold.
Safflower enters heart and liver meridians, and is pungent and warm in nature. Has effects in promoting blood circulation, dredging channels, removing blood stasis, and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, traumatic injury, sore, ulcer, and swelling and pain.
Cyperus rotundus enters liver, spleen and triple energizer meridians, and is pungent, slightly bitter, slightly sweet and mild in nature and taste. Has effects in promoting qi circulation, resolving stagnation, regulating menstruation, and relieving pain. Can be used for treating stagnation of qi due to stagnation of liver-qi, chest pain, hypochondrium pain, abdominal distention and pain, dyspepsia, chest and abdominal distention and fullness, hernia due to cold, abdominal pain, breast pain, menoxenia, amenorrhea, and dysmenorrhea.
Spatholobus stem enters liver and kidney meridians, and is bitter, sweet and warm in nature and taste. Has effects in tonifying blood, promoting blood circulation, and dredging meridians. Can be used for treating menoxenia, blood deficiency, sallow complexion, numbness, paralysis, and rheumatalgia.
Ginger enters lung, spleen and stomach meridians, and is pungent in property and flavor and slightly warm in nature. Has effects in relieving exterior syndrome, dispelling cold, warming middle warmer, relieving vomit, eliminating phlegm, and relieving cough. Can be used for treating common cold due to wind-cold, emesis due to stomach cold, and cough due to cold phlegm.
The hydrogen-rich activation powder is mixed powder of composite powder and hydrogen powder, contains hydrogen molecules and has very strong permeability, so the hydrogen-rich activation powder and the isorubiadin in morinda officinalis are matched with each other to use, and the hydrogen-rich activation powder has better effect of removing free radicals, and the free radicals are sources of various diseases and come from various pollutants, chemical substances and the like in daily life. The hydrogen-rich activating powder has the effects of dispersing wind heat and clearing blood toxin; it also has effects in resisting pathogenic microorganism, relieving inflammation, relieving pain and fever, rapidly diminishing inflammation, improving arthritis, and removing free radicals.
In some embodiments of the present application, the anti-inflammatory and analgesic traditional Chinese medicine package is characterized by comprising the following raw materials in parts by weight: 23-25 parts of vitex negundo leaf, 23-25 parts of notopterygium root, 15-18 parts of folium artemisiae argyi, 15-18 parts of safflower, 15-18 parts of radix angelicae pubescentis, 10-12 parts of rhizoma cyperi, 10-12 parts of caulis spatholobi, 6-8 parts of ginger and 6-8 parts of hydrogen-rich activating powder.
In some embodiments of the present application, the anti-inflammatory and analgesic traditional Chinese medicine package is characterized by comprising the following raw materials in parts by weight: 25 parts of vitex leaves, 25 parts of notopterygium roots, 18 parts of folium artemisiae argyi, 18 parts of safflower carthamus, 18 parts of radix angelicae pubescentis, 12 parts of rhizoma cyperi, 12 parts of caulis spatholobi, 8 parts of ginger and 8 parts of hydrogen-rich activation powder.
A preparation method of a traditional Chinese medicine package for diminishing inflammation and easing pain comprises the following steps:
pretreatment of medicinal materials: removing impurities from folium Viticis Cannabifoliae, parching; soaking Notopterygii rhizoma in 30-40 deg.C water; soaking folium Artemisiae Argyi, Carthami flos, radix Angelicae Pubescentis, rhizoma Cyperi, caulis Spatholobi and rhizoma Zingiberis recens in tap water, mixing all the above processed raw materials, pulverizing, and drying to obtain micropowder;
preparing an extract: adding the dried micro powder into an organic solvent, standing, performing microwave-assisted extraction to obtain an extracting solution, centrifuging the extracting solution to obtain a supernatant, adding ammonium sulfate, standing for layering, centrifuging the supernatant to obtain a supernatant, and preparing the extract into the traditional Chinese medicine bag.
In some embodiments of the present application, the fine powder has a particle size of 3 to 10 μm. The micro powder with the particle size within the range is particularly small, which is beneficial to the medicine powder in the medicine bag to quickly permeate into water.
In some embodiments of the present application, the drying temperature is 30-40 ℃ and the drying is carried out to a moisture content of less than 3 wt%. The drying temperature is not suitable to be too low or too high, and the drying temperature is usually 30-40 ℃ and is a suitable temperature range; the medicinal bag made of the dried medicinal materials is more beneficial to dissolving out the active ingredients in the medicinal materials, the medicinal materials can be prevented from mildewing when being dried, and the medicinal bag is generally dried until the water content is less than 3wt percent.
In some embodiments of the present application, the organic solvent is one of methanol, ethanol, isopropanol, acetone, acetic acid, dichloromethane, trichloroacetic acid, and n-butanol. In the microwave-assisted extraction, the selection of an extraction solvent is crucial to the extraction result, and the extraction rate of effective components is directly influenced. Firstly, the solvent must have certain polarity to absorb microwave energy for internal heating; secondly, the selected organic solvent has strong dissolving capacity to the target extract; the organic solvents all meet the requirements.
In some embodiments of the present application, the microwave-assisted extraction comprises: treating with 175-450W microwave intensity for 1-5min, and extracting with the above organic solvent at 60-70 deg.C. Under the conditions, the extraction of the effective components in the medicinal materials is more facilitated.
In some embodiments of the present application, in the step of preparing the extract, the rotation speed of the centrifugation is 4000-5500rpm/min, and the time of the centrifugation is 5-15 min. The centrifugation time is too short, the rotating speed is too low, and the supernatant and the lower-layer sediment are not easy to separate; the centrifugal time is too long, the rotating speed is too high, the sediment at the lower layer is too tight to be conveniently pulled out for cleaning the subsequent centrifugal cup.
In some embodiments of the present application, the above-mentioned standing time is 5 to 15 min. The standing is performed for separating two phases, but the standing time is not too long, but the two phases are separated, so the standing time is suitably 5 to 15 min.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
The traditional Chinese medicine package bag for diminishing inflammation and easing pain comprises the following raw materials in parts by weight: 25g of vitex negundo leaf, 25g of notopterygium root, 18g of folium artemisiae argyi, 18g of safflower, 18g of radix angelicae pubescentis, 12g of rhizoma cyperi, 12g of caulis spatholobi, 8g of ginger and 8g of hydrogen-rich activation powder.
The preparation method comprises the following steps:
pretreatment of medicinal materials: removing impurities from folium Viticis Cannabifoliae, and parching; soaking Notopterygii rhizoma in 35 deg.C water for 1 h; soaking folium Artemisiae Argyi, Carthami flos, radix Angelicae Pubescentis, rhizoma Cyperi, caulis Spatholobi and rhizoma Zingiberis recens in tap water for 0.5h, and mixing all the above processed materials, pulverizing, and drying to obtain micropowder;
preparing an extract: adding 80% ethanol into the dried micropowder, shaking, standing for 10min, treating with 375W microwave intensity for 5min, extracting at 65 deg.C for 1h to obtain extractive solution, centrifuging (4000rpm/min for 10min), collecting supernatant, adding ammonium sulfate, standing for layering, and collecting the upper layer liquid as ethanol phase. Centrifuging the supernatant to obtain supernatant as extract.
Preparing a medicine package: drying the above extracts in oven at 40 deg.C until water content is less than 3 wt% to obtain medicinal powder, mixing the medicinal powder with hydrogen-rich activating powder, and packaging into non-woven fabric bags to obtain medicinal bag. It should be noted that the content of the powder in the pouch may be 30, 60, 80, 100g, etc., which is not limited in the present application.
The hydrogen-rich activation powder is mixed powder of composite powder and hydrogen powder, and the mixing ratio of the composite powder to the hydrogen powder is 1: 1, the composite powder and the hydrogen powder are purchased from Huangpegchang cosmetics Co., Ltd.
Example 2
The traditional Chinese medicine package bag for diminishing inflammation and easing pain comprises the following raw materials in parts by weight: 22g of vitex leaves, 22g of notopterygium roots, 15g of folium artemisiae argyi, 15g of safflower, 15g of radix angelicae pubescentis, 10g of rhizoma cyperi, 10g of caulis spatholobi, 6g of ginger and 6g of hydrogen-enriched activating powder.
The preparation method comprises the following steps:
pretreatment of medicinal materials: removing impurities from folium Viticis Cannabifoliae, and parching; soaking Notopterygii rhizoma in 30 deg.C water for 1.5 h; soaking folium Artemisiae Argyi, Carthami flos, radix Angelicae Pubescentis, rhizoma Cyperi, caulis Spatholobi and rhizoma Zingiberis recens in tap water for 1h, mixing all the above processed raw materials, pulverizing, and drying to obtain micropowder;
preparing an extract: adding 80% ethanol into the dried micropowder, shaking, standing for 6min, treating with 450W microwave intensity for 3min, extracting at 60 deg.C for 1h to obtain extractive solution, centrifuging the extractive solution (10 min/5000 rpm), collecting supernatant, adding ammonium sulfate, standing for layering, and collecting the upper layer liquid as ethanol phase. Centrifuging the supernatant to obtain supernatant as extract.
Preparation of the medicine package: drying the above extracts in oven at 30 deg.C until water content is less than 3 wt% to obtain medicinal powder, mixing the medicinal powder with hydrogen-rich activating powder, and packaging into non-woven fabric bags to obtain medicinal bag. The content of the powder in the pouch may be 30, 60, 80, 100g, etc., which is not limited in the present application.
The hydrogen-rich activation powder is mixed powder of composite powder and hydrogen powder, and the mixing ratio of the composite powder to the hydrogen powder is 2: 1, the composite powder and the hydrogen powder are purchased from Huangpechang cosmetics Co., Ltd.
Example 4
The traditional Chinese medicine package bag for diminishing inflammation and easing pain comprises the following raw materials in parts by weight: 24g of vitex negundo leaves, 24g of notopterygium roots, 16g of folium artemisiae argyi, 16g of safflower, 16g of radix angelicae pubescentis, 11g of rhizoma cyperi, 11g of caulis spatholobi, 7g of ginger and 7g of hydrogen-rich activation powder.
The preparation method comprises the following steps:
pretreatment of medicinal materials: removing impurities from folium Viticis Cannabifoliae, and parching; soaking Notopterygii rhizoma in 32 deg.C water for 1.3 h; soaking folium Artemisiae Argyi, Carthami flos, radix Angelicae Pubescentis, rhizoma Cyperi, caulis Spatholobi and rhizoma Zingiberis recens in tap water for 0.7h, mixing all the above processed raw materials, pulverizing, and drying to obtain micropowder;
preparing an extract: adding 80% ethanol into the dried micropowder, shaking, standing for 12min, treating with 350W microwave intensity for 2min, extracting at 70 deg.C for 1h to obtain extractive solution, centrifuging (4500rpm/min 12min), collecting supernatant, adding ammonium sulfate, standing for layering, and collecting upper layer liquid as ethanol phase. Centrifuging the supernatant to obtain supernatant as extract.
Preparing a medicine package: drying the above extracts in oven at 37 deg.C until water content is less than 3 wt% to obtain medicinal powder, mixing the medicinal powder with hydrogen-rich activating powder, and packaging into non-woven fabric bags to obtain medicinal bag. It should be noted that the content of the powder in the pouch may be 30, 60, 80, 100g, etc., which is not limited in the present application.
The hydrogen-rich activation powder is mixed powder of composite powder and hydrogen powder, and the mixing ratio of the composite powder to the hydrogen powder is 1: 2.5, the composite powder and the hydrogen powder are purchased from Huangpechang cosmetics Co., Ltd.
Example 5
The traditional Chinese medicine package bag for diminishing inflammation and easing pain comprises the following raw materials in parts by weight: 23g of vitex negundo leaf, 23g of notopterygium root, 20g of folium artemisiae argyi, 17g of safflower, 17g of radix angelicae pubescentis, 12g of rhizoma cyperi, 12g of caulis spatholobi, 9g of ginger and 8g of hydrogen-rich activating powder.
The preparation method comprises the following steps:
pretreatment of medicinal materials: removing impurities from folium Viticis Cannabifoliae, parching; soaking Notopterygii rhizoma in 38 deg.C water for 1.7 h; soaking folium Artemisiae Argyi, Carthami flos, radix Angelicae Pubescentis, rhizoma Cyperi, caulis Spatholobi and rhizoma Zingiberis recens in tap water for 0.8h, and mixing all the above processed materials, pulverizing, and drying to obtain micropowder;
preparing an extract: adding 80% ethanol into the dried micropowder, shaking, standing for 12min, treating with 175W microwave intensity for 1min, extracting at 63 deg.C for 1.5h to obtain extractive solution, centrifuging (5500rpm/min for 5min) to obtain supernatant, adding ammonium sulfate, standing for layering, and collecting the upper layer liquid as ethanol phase. Centrifuging the supernatant to obtain supernatant as extract.
Preparing a medicine package: drying the above extracts in oven at 35 deg.C until water content is less than 3 wt% to obtain medicinal powder, mixing the medicinal powder with hydrogen-rich activating powder, and packaging into non-woven fabric bags to obtain medicinal bag. The content of the powder in the pouch may be 30, 60, 80, 100g, etc., which is not limited in the present application.
The hydrogen-rich activation powder is mixed powder of composite powder and hydrogen powder, and the mixing ratio of the composite powder to the hydrogen powder is 2.5: 1, the composite powder and the hydrogen powder are purchased from Huangpegchang cosmetics Co., Ltd.
Comparative example 1
The comparative example differs from example 1 in that: the Vitex negundo L.leaves of example 1 were replaced by Saxifraga foetida.
Comparative example 2
The comparative example differs from example 1 in that: in this comparative example, no hydrogen-rich activating powder was added.
Effects of the invention
256 volunteers, 132 males, 124 females of patients with inflammation were recruited, aged 20-75 years, with a course of 30-180 days, randomized into 7 groups with no significant difference in each group. The symptoms of the patients with inflammation comprise patients with wind-cold type common cold, patients with hepatitis, patients with bronchitis and the like.
The application method of the anti-inflammatory and analgesic traditional Chinese medicine bag provided by the application for the volunteers of the patients with inflammation regularly comprises the following steps: the medicine bag is put into warm water at 42-45 ℃, and the medicine bag is kneaded to ensure that the effective components in the medicine bag are fully dissolved in the water. The bath is carried out for 30-40 minutes at night every day, and the drug effect is counted after 7 days of use.
Before treatment and 7 days after treatment, follow-up observation is carried out, and symptoms, sign changes and adverse reactions are recorded at each follow-up visit.
Therapeutic efficacy judgment criteria
And (3) curing: the symptoms in the diagnostic criteria are completely disappeared, and the normal work, life, learning and labor can be realized.
The method has the following advantages: symptoms referred to in the diagnostic criteria are improved and markedly improved, requiring continued treatment.
And (4) invalidation: the symptoms referred to in the diagnostic criteria are not improved and tend to be even more severe, and other medications are required to be selected for treatment.
The above patients started to count the efficacy 7 days after using the anti-inflammatory and analgesic traditional Chinese medicine bag provided in the present application, and the results are shown in table 1.
TABLE 1 statistics of drug effects
The total effective rate is (effective number of people + clinical cure number)/total number of people;
as can be seen from the table 1, the total effective rate of the traditional Chinese medicine composition prepared in the embodiments 1-5 of the invention for treating the patients with inflammation is more than 85%, and the clinical cure rate of the embodiment 1 is as high as 92%, which shows that the traditional Chinese medicine composition in the embodiment 1 has the best anti-inflammatory and analgesic effects; in comparative example 1, the vitex negundo leaves in example 1 are replaced by the saxifrage, which also has the anti-inflammatory effect, but the cure rate of comparative example 1 is only 81%, which indicates that the saxifrage possibly has a mutual killing effect with other medicines, and the vitex negundo leaves not only have the anti-inflammatory effect but also have a harmonizing effect in the traditional Chinese medicine composition of the application, so that the raw materials are synergistic, and a better effect is achieved; in the comparative example 2, hydrogen-rich activation powder is not added, the cure rate of the traditional Chinese medicine composition is only 79%, the hydrogen-rich activation powder contains hydrogen powder, the hydrogen powder has small particle size and strong permeability, and when the hydrogen-rich activation powder is used in combination with various medicines, active ingredients in the medicinal materials can be quickly permeated into water, so that the maximum medicinal effect of each medicinal material is exerted, and the hydrogen-rich activation powder also has the effect of removing free radicals. In conclusion, the vitex leaves and the hydrogen-rich activation powder are very important in the traditional Chinese medicine composition for treating sexual dysfunction provided by the invention.
In summary, the present application provides an anti-inflammatory and analgesic traditional Chinese medicine package and a preparation method thereof. In the application, caryophyllene which is a main component of vitex leave volatile oil has the effects of eliminating phlegm, relieving asthma, improving organism immunity, resisting bacteria and diminishing inflammation, notopterygium root has the functions of dredging the limb, smoothing blood vessels, attacking pathogenic factors and dispersing wind-cold and rheumatism, and the notopterygium root volatile oil has the effects of relieving heat and resisting bacteria, has the effects of dredging channels, relieving heat syndrome and resisting bacteria and diminishing inflammation when being matched, and is a monarch drug; the folium artemisiae argyi, the safflower and the radix angelicae pubescentis are matched together to serve as ministerial drugs and assist monarch drugs to achieve better effects, wherein the volatile oil of the folium artemisiae argyi has the effect of killing or inhibiting various germs, the folium artemisiae argyi can dredge twelve meridians, particularly the drugs of liver, spleen and kidney, and is good at warming middle energizer, expelling cold and removing dampness, and moving qi in blood, the safflower can dredge meridians and collaterals, and is a qi-flowing drug in blood, can be used for purging and tonifying, and has miraculous meanings, the radix angelicae pubescentis is a main drug for dispelling wind and dredging collaterals, and has the effects of diminishing inflammation, relieving pain, tonifying middle energizer, benefiting qi and dredging channels and promoting blood circulation by matching, the rhizoma cyperi and the caulis spatholobi are also used as adjuvant drugs, wherein the rhizoma cyperi can be used for dispelling stasis and dispersing qi, the volatile oil of the rhizoma cyperi has the effects of relieving pain and resisting bacteria, the caulis spatholobi has the effects of replenishing blood, promoting blood circulation and dredging collaterals, the qi can be used for dispelling stagnation, and relieving pain and resisting bacteria, and finally the ginger is used as a messenger drug, the ginger is used for relieving exterior syndrome, dispelling cold, warming middle energizer and stopping vomiting, and all the medicines can be used for diminishing inflammation, relieving pain, and relieving pain, Tonify qi and blood, dredge meridians and collaterals, and reach focus of infection directly. In addition, the creation point of the application is that the hydrogen-rich activation powder in the compatibility of the traditional Chinese medicine composition contains hydrogen powder, the hydrogen powder has small diameter and strong permeability, and when the hydrogen-rich activation powder is used in combination with various medicines, the active ingredients in the medicinal materials can be quickly permeated into water, so that the maximum medicinal effect of each medicinal material is exerted, and the hydrogen-rich activation powder also has the effect of removing free radicals. In the application, the hydrogen-rich activation powder is added into the traditional Chinese medicine bag, so that the medicine effect can be enhanced, and the application has the advantages of reasonable medicine application, combination of various medicines, and effects of analgesia, anti-inflammation, antipyresis and free radical removal. In addition, the medicine bag can also treat gout, arthritis, high uric acid, fibroma and other symptoms.
The medicine bag can be used for foot bath or bubble bath, and can be determined according to the actual condition of an individual, and the drug effect of the medicine bag is not influenced by the two using modes.
According to the preparation method of the traditional Chinese medicine bag for diminishing inflammation and relieving pain, the extraction efficiency of the effective components in the raw materials is high, so that the treatment effect of the composition is good, and the drug effect can be exerted to the maximum.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. The traditional Chinese medicine bag for diminishing inflammation and relieving pain is characterized by comprising the following raw materials in parts by weight: 22-26 parts of vitex negundo leaf, 22-26 parts of notopterygium root, 15-20 parts of folium artemisiae argyi, 15-20 parts of safflower, 15-20 parts of radix angelicae pubescentis, 10-14 parts of rhizoma cyperi, 10-14 parts of caulis spatholobi, 6-9 parts of ginger and 6-9 parts of hydrogen-rich activation powder.
2. The traditional Chinese medicine package for diminishing inflammation and easing pain as claimed in claim 1, is characterized by comprising the following raw materials in parts by weight: 23-25 parts of vitex negundo leaf, 23-25 parts of notopterygium root, 15-18 parts of folium artemisiae argyi, 15-18 parts of safflower, 15-18 parts of radix angelicae pubescentis, 10-12 parts of rhizoma cyperi, 10-12 parts of caulis spatholobi, 6-8 parts of ginger and 6-8 parts of hydrogen-rich activation powder.
3. The traditional Chinese medicine package for diminishing inflammation and easing pain as claimed in claim 2, which is characterized by comprising the following raw materials in parts by weight: 25 parts of vitex leaves, 25 parts of notopterygium roots, 18 parts of folium artemisiae argyi, 18 parts of safflower carthamus, 18 parts of radix angelicae pubescentis, 12 parts of rhizoma cyperi, 12 parts of caulis spatholobi, 8 parts of ginger and 8 parts of hydrogen-rich activation powder.
4. A method for preparing an anti-inflammatory and analgesic traditional Chinese medicine package according to any one of claims 1 to 3, which comprises the following steps:
pretreatment of medicinal materials: removing impurities from folium Viticis Cannabifoliae, parching; soaking Notopterygii rhizoma in 30-40 deg.C water; soaking folium Artemisiae Argyi, Carthami flos, radix Angelicae Pubescentis, rhizoma Cyperi, caulis Spatholobi and rhizoma Zingiberis recens in tap water, mixing all the above processed raw materials, pulverizing, and drying to obtain micropowder;
preparing an extract: adding the dried micro powder into an organic solvent, standing, performing microwave-assisted extraction to obtain an extracting solution, centrifuging the extracting solution to obtain a supernatant, adding ammonium sulfate, standing for layering, centrifuging the supernatant to obtain a supernatant, and preparing the extract into the traditional Chinese medicine bag.
5. The method for preparing a Chinese medicinal bag for relieving inflammation and pain as claimed in claim 4, wherein the particle size of the micropowder is 3-10 μm.
6. The method for preparing a Chinese medicinal bag for relieving inflammation and pain as claimed in claim 4, wherein the drying temperature is 30-40 deg.C, and the drying is carried out until the water content is less than 3 wt%.
7. The method for preparing a pharmaceutical pack for anti-inflammatory and analgesic use according to claim 4, wherein the organic solvent is one of methanol, ethanol, isopropanol, acetone, acetic acid, dichloromethane, trichloroacetic acid and n-butanol.
8. The method of claim 7, wherein the microwave-assisted extraction comprises: treating with 175-450W microwave intensity for 1-5min, and extracting with the organic solvent at 60-70 deg.C.
9. The method as claimed in claim 4, wherein the rotation speed of the centrifugation is 4000-5500rpm/min and the time of the centrifugation is 5-15min in the step of preparing the extract.
10. The method of claim 4, wherein the rest time is 5-15 min.
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Application publication date: 20220722 |